#Herbal #Cleaver #Decoction and Extract Inhibit the Risk of Resistant #LaryngealCancer Cells in Vitro, Scientists Suggest

Kyle J. Norton

The larynx is also known as the voice box, located between the pharynx and the trachea. Its function is to ensure the airways to open when we breathe and talk and closed when we swallow to ensure no food gets into the trachea.

Laryngeal cancer is a medical condition characterized by irregular cell growth in the tissues of the larynx. The cancer cells may spread to other tissues and organs in the late stage via lymph and blood circulation.

The exact cause of laryngeal cancer is unknown. Researchers do not know why people in the same family with the same health conditions and gender, are susceptible to the onset of the disease while others do not.

However, they do know that certain risk factors such as smoking, excessive alcohol drinking, unhealthy diet, family history, HPV infection, and long-term exposure to some chemicals including wood dust, soot coal dust, and paint fumes can increase the risk of cancer.

Genetic mutation inherited from the parents, such as TP53, GSTM3, and NAT2, and long-term use of some medication, such as immune-suppressive drugs to fight off infections such as HIV or AIDs is considered the prevalent risk factors for the disease development.


The most common symptoms of the larynx (Voice Box) cancer include
* Hoarseness or other voice changes
Due to malignant cells have invaded the vocal cords.

* A cough that doesn't go away or stridor
Due to blocking of the airway.

* Breathing difficulties
The tumor has grown large enough to block off the airway.

* Ear pain
The tumor has pressed onto the nerve.

*A lump or mass in the neck or throat
Cancer has invaded the nearby lymph nodes in the neck and throat.

* Coughing up of blood
Breaking off of some malignant cells.

Cleaver is a herbaceous annual plant, genus Galium, belongings to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as a mild diuretic and blood and lymphatic cleanser to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stones, etc.

In finding a potential compound for the treatment of cancer, researchers investigated a Galium verum decoction in chemosensitive (Hep-2 and HLaC79) and chemoresistant, P-glycoprotein-overexpressing (Hep2-Tax, HLaC79-Tax) laryngeal carcinoma cell lines.

According to the results from the detailed spheroid-based 3D invasion analysis of Hep2 and Hep2-Tax in semisolid collagen gels and on different extracellular matrix coatings, Galium decoction proved to be even more pronounced in the more aggressively invading chemoresistant Hep2-Tax cell line compared to the administration of Galium aqueous extract.

Furthermore, the application of decoction also inhibited the expression of the enzyme gelatinolytic activity produced by the MMP-2 in three of the four cell lines without affecting the angiogenesis in the tested cell lines.

Interestingly, Galium decoction demonstrated an anti-HLaC79 and Hep2, Hep2-Tax, and HLaC79-Taxactivity with no influencing unique pathway activation.

Based on the findings, researchers said, " the intake of HCA has preventive effects on bone loss in STZ-diabetic rats, and that the intake has partially restorative effects on serum biochemical findings in the diabetic state".

Taken together, herbal cleaver may be considered an anti-resistant laryngeal cancer remedy, pending the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of Galium verum aqueous extract on growth, motility, and gene expression in drug-sensitive and -resistant laryngeal carcinoma cell lines by Schmidt M1, Scholz CJ2, Gavril GL3, Otto C1, Polednik C1, Roller J1, Hagen R. (PubMed)

#Herbal #Ashwagandha Processes Significant Apoptotic Properties Associated with Cardioprotective Effects, Researchers Show

Kyle J. Norton

Acute brain infarction is a medical condition characterized by the obstruction of the blood supply to the brain, causing the local death of the brain tissue.

The occurrence and extent of brain infarction are associated with three basic factors, including the site of arterial occlusion, the rapidity of arterial occlusion, and the presence or absence of collateral circulation.

In other words, brain infarction can be classified into myocardial infarction due to plaque rupture and myocardial oxygen supply-demand imbalance secondary to other acute illnesses.

Myocardial infarction (MI), or heart attack is a condition caused by the decrease or blockage of blood flow to a part of the heart that damage the heart muscle.


Reperfusion injury or ischemia-reperfusion injury (IRI) or reoxygenation injury, is when blood supply returns to damaged tissues after a period of ischemia or lack of oxygen (anoxia or hypoxia). caused by the decrease or blockage of blood flow to a part of the heart.

Atherosclerosis, one of the major causes of cardiovascular disease is a medical condition caused by the accumulation of plaque on the arterial wall. Over time, the condition can lead to narrowing arteries or blocked arteries, leading to reduce oxygenated blood flow to the heart and other parts of the body.

Arteries are blood vessels carried oxygen-rich blood to the heart before passing them to the tissues and organs.

Plague is made up of fat, cholesterol, calcium, and other substances found in the blood. In other words, cholesterol that cannot be returned to the liver for reuse may have a strong impact to induce plaque accumulation.

There are many factors associated with the risk of acute infarction. However, aging may have a strong and negative implication on acute infarction.

Dr. Mehta RH, the lead scientist wrote, "Older age was associated with a greater proportion of patients with functional limitations, heart failure, prior coronary disease, and renal insufficiency and a lower proportion of male and diabetic patients".

And, "...age-associated differences in clinical characteristics in elderly patients with acute myocardial infarction (AMI), which account for some of the age-associated differences in mortality".

Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In finding a potent compound for the promotion of heart health, researchers evaluated the cardioprotective mechanisms of Withania somnifera (Ws), in the setting of ischemia and reperfusion (IR) injury.

In vivo, selected Wistar rats were divided into three groups that received oral saline (sham, control IR) and Ws-50 mg/kg (Ws-IR), respectively, for 1 month. Then, on day 31, in rats of control IR and Ws-IR group, LAD coronary artery occlusion was undertaken for 45 min followed by 1 h reperfusion.

Based on the tested analysis, post-ischemic reperfusion injury was found to induce significant cardiac necrosis, apoptosis, and a decline in antioxidant status.

Furthermore, elevation in lipid peroxidation was also found in the IR control group, compared to the sham group.

Ws treatment group not only restored the myocardial oxidant-antioxidant balance but also inhibited the makers of apoptotic effects induced by ischemia-reperfusion injury.

Moreover, Ws protects additional post-ischemic reperfusion injury-induced further myocardial damage in the tested rats by increasing the levels of proteins associated with anti-apoptotic activity and decreasing the protein involved in pro-apoptotic activity, evidenced by histopathologic evaluation.

Based on the findings, researchers said, "The antioxidant and anti-apoptotic properties of Ws may contribute to the cardioprotective effects.".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and treatment of myocardial damage in post-ischemic reperfusion injury, pending the result of a larger sample size and multicenter study


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Withania somnifera provides cardioprotection and attenuates ischemia-reperfusion-induced apoptosis by Mohanty IR1, Arya DS, Gupta SK. (PubMed)
(2) Acute myocardial infarction in the elderly: differences by age by Mehta RH1, Rathore SS, Radford MJ, Wang Y, Wang Y, Krumholz HM. (PubMed)

#Cucumber Balances the Ratio of Microbiota Composition by Inhibiting the Production of Pro-Inflammatroy Cytokines, Researchers Suggest

Kyle J. Norton

Gut microbiome made up of trillions of microorganisms is the bacterial composition found in the gut of the digestive tract.
In a healthy individual, the ratio of the bacterial composition is balanced. In other words, the bad bacteria in the digestive tract is totally countered by the presence of good bacteria.

However, the imbalanced ratio of the composition of the gut microbiota has been associated with chronic diseases ranging from inflammatory bowel disease (IBD), obesity, and allergic disorders, in both human and animal models.

Believe it or not, gut microbes have been found to influence many aspects of human health including immune, metabolic, and neurobehavioural traits.


In immunity, balance of the gut microbes showed to stimulate the immune function against inflammatory immune disorders.

Digestively, balanced gut microbes protect the gut against gastrointestinal diseases and non-gastrointestinal diseases. caused by overexpression of bad bacteria.

In metabolism, gut microbes influence what the human host is able to extract from its diet, such as nutrients, thus reducing the risk of obesity and obesity complication.

Neurologically, gut microbiota can control brain insulin signaling and metabolite levels that play a critical role in neurobehaviors.

Some researchers suggested, there are huge benefits that influence the function of the brain, immunity, heart, and digestive system and reduce the risk of chronic diseases and conditions such as diabetes and metabolic syndrome by maintaining a good ratio of the gut microbiome.

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to discover a natural ingredient for balancing the ratio of microbiota composition, researchers investigated and evaluated cucumber phytochemical compositions along with their potential gut microbiota modulating, free radical scavenging, and anti-inflammatory capacities.

Seed flour extracts from cucumber enhanced the total number of gut bacteria by altering the abundance of specific bacterial phylum or genus in vitro.

In other words, cucumbers improved digestive functioning by enhancing the ratio of microbiota compositions in the gut.

Compared to broccoli and carrot seed flour extracts, cucumber seed extract showed the least effect in DPPH radical scavenging capacity, oxygen radical absorbing capacity, and hydrdoxyl radical (HO•) scavenging capacity values of 85, 634, and 270 μmol Trolox equivalent (TE)/g.

In the tested J774A.1 cells, cucumber suppressed the LPS-induced production of pro-inflammatory cytokines.

In order to reveal more information on cumber in the improvement of gut microbiota, composition researchers examined Cucumis melo L. (Cucumis) on obesity-induced IR in genetically leptin-deficient Lepob/Lepob mice.

According to the tested assays, Cucumis improved IR and relieved inflammation in adipose tissue and blood which lead to the balance of the ratio of microbiota composition.

Dr. Lee D, the lead scientist after taking into account co and confounders wrote, "administration of Cucumis improved IR by reducing inflammation, thereby changing the gut microbiota composition".

Taken altogether, fermented cucumber may be used for the treatment of digestive dysfunction by improving the ratio of gut microbiota composition, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the Gut Microbiome in Lepob/Lepob Mice by Lee D1, Yoo JH1, Lee BC. (PubMed)
(2) Chemical Compositions of Cold-Pressed Broccoli, Carrot, and Cucumber Seed Flours and Their in Vitro Gut Microbiota Modulatory, Anti-inflammatory, and Free Radical Scavenging Properties by Choe U1, Li Y1,2, Gao B2, Yu L1, Wang TTY, Sun J, Chen P, Liu J3, Yu L1. (PubMed)

#Isothiocyanates Found in #CruciferousVegetables inhibits the Pathways Associated with Inducing the Death of Bladder Cancer Cells

Kyle J. Norton

The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.

Bladder cancer is a medical condition characterized by irregular cell growth in the bladder tissue due to the alternation of DNA.

Most cases of primary bladder cancer start on the cell on the surface of the inner lining. However, after growing large enough, the cancerous call can spread to other regions in the body through the circulation of fluids and blood.

According to the statistic. 90% of bladder cancer were diagnosed in people who are older than 55. and the average age of people diagnosed with bladder cancer is 73.

Every year, the disease causes over 17,000 deaths, and bladder cancer is the eighth most common cause of cancer death in men.

Bladder cancer is the most common type of cancer that affects men twice as frequently as it affects women.

Usually, it starts from the lining of the bladder caused by several types of malignant growths of the urinary bladder cells.
Although there are many risk factors associated with the onset of bladder cancer, long-term cigarette smoking use is considered a significant cause of the disease. Smokers are 4 to 7 times more likely to develop bladder cancer than nonsmokers.

However, most of cigarette smoker has never developed bladder cancer.


In finding a potential plant that processes anti-cancer activity researchers evaluated the diets rich in cruciferous vegetables, particularly broccoli on bladder cancer risk.

In vitro studies, isothiocyanates, the major chemical compound of cruciferous vegetables inhibited bladder cancer cell lines, induced cell cycle arrest, and apoptosis.

Furthermore, isothiocyanates demonstrated many mechanisms of anticancer activity at the steps of cancer initiation, promotion, and progression.

Moreover, isothiocyanates induced cancer cell death by targeting multiple pathways including the adaptive stress response, phase I/II enzyme modulation, pro-growth, pro-survival, pro-inflammatory signaling, angiogenesis, and even epigenetic modulation, according to multiple in vivo studies.

Collectively, researchers said, "Overall, both cell and animal studies support a potential role for isothiocyanates in bladder cancer prevention and treatment. Future studies are necessary to examine clinically relevant outcomes and define guidelines on ameliorating the bladder cancer burden".

Taken together, collard green consists of isothiocyanates that may be considered a functional food for the prevention and treatment of bladder cancer pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention by Abbaoui B1,2,3, Lucas CR3,4,5, Riedl KM2,5, Clinton SK5,6, Mortazavi A. (PubMed)

#Garlic or Aged-Garlic-Extract Inhibit Parameters Associated with the Onset of #Hypertension, Scientists Suggest

Kyle J. Norton

Scientists may have found a common kitchen spice with the potential in reducing high blood pressure quickly without including any side effects, some studies endorsed.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

High blood pressure means raising the pressure in your heart. If it stays high over time it can damage the body in many ways.

The causes of hypertension are unknown. However, researchers do know that acute hypertension is induced by daily stress.

Certain risk factors such as unhealthy lifestyle choices, physical inactivity unhealthy diet with high saturated and trans fat, refined products, processed food, and high sugar, and salt intake,...... over time cause your blood pressure to spice up chronically.

Lifestyle choices can also lead to being overweight or obese, the risk factors for the early onset of hypertension.

According to the statistic, in the US, over 75 million adults or 32% have high blood pressure.


In other words, 1 in every 3 American adults has the syndrome. Sadly 44% of the mentioned adults with high blood pressure are not under control.

Uncontrol high blood pressure has long been known as a major risk factor for the development of heart disease and stroke, the leading causes of death in the United States.

Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects such as gastrointestinal discomfort, tiredness, weakness, and headache.

Some patients who are taking hypertensive medicine over prolonged periods of time may experience symptoms of erectile dysfunction.

In severe cases, the intake of antihypertensive drugs for the long term can cause dermatitis, arthritis and anemia and lupus erythematosus-like syndrome, according to the article "Adverse Effects of Antihypertensive Drugs" written by Dr. DWARD D. FREIS, M.D.

If you are currently taking any anti-high blood pressure medications, please make you that you know all the side effects.

Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia.

The kitchen spice has been used popularly in traditional and Chinese medicine in treating the common cold and flu, blood pressure cholesterol levels, natural antibiotics, etc.

In adult men and women, who participated in the Tehran Lipid and Glucose Study (2006-2008 to 2012-2014), the intake of garlic is associated to reduce the risk of hypertension by up to 26%.

In hypertension of 80-90% of patients with excess glucocorticoid levels, allicin found in garlic attenuated dexamethasone-induced anorexia and loss of total body weight.

A randomized, placebo-controlled, clinical trial conducted on 56 CVD patients, aged 25 - 75 years old also suggested treatment with garlic-based drugs can be effective for controlling BP in CVD patients and has no interaction with other drugs that CAD patients take, after 3 months of the administration.

Dr. Takashima M the lead author at the Wakunaga Pharmaceutical Co. Ltd said, "Aged garlic extract (AGE) is effective in reducing the blood pressure of hypertensive patients,......AGE-induced the concentration-dependent vasorelaxation of isolated rat aortic rings that had been precontracted with norepinephrine"

In fact, traditional Chinese medicine, food therapy, and hypertension control, all recommended that garlic is of the food to be used for hypertension control, according to a statistical analysis of antihypertensive foods recommended in 20 books on the application of food therapy for hypertension control.

If you can control your diet, make changes to lifestyle, maintaining an ideal weight, you could do just fine without the drugs,

Taken together, garlic may be used as preventive and controlling effects for patients with or without high blood pressure. Some researchers insisted that garlic's anti-hypertension effect may result from its anticoagulant property.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats by Dubey H1,2, Singh A1, Patole AM2, Tenpe CR2(PubMed)
(2) Allium vegetable intakes and the incidence of cardiovascular disease, hypertension, chronic kidney disease, and type 2 diabetes in adults: a longitudinal follow-up study by Bahadoran Z1, Mirmiran P, Momenan AA, Azizi F.(PubMed)
(3) Does Garlic Supplementation Control Blood Pressure in Patients with Severe Coronary Artery Disease? A Clinical Trial Study by Mahdavi-Roshan M1, Nasrollahzadeh J1, Mohammad Zadeh A2, Zahedmehr A3. (PubMed)
(4) Traditional Chinese Medicine, Food Therapy, and Hypertension Control: A Narrative Review of Chinese Literature by Zou P1(PubMed)
(5) The anticoagulant rivaroxaban lowers portal hypertension in cirrhotic rats mainly by deactivating hepatic stellate cells by Vilaseca M1,2, García-Calderó H1,3, Lafoz E1,2, García-Irigoyen O3,4, Avila MA3,4, Reverter JC5, Bosch J1,2,3,6, Hernández-Gea V1,3, Gracia-Sancho J1,2,3, García-Pagán JC1,2,3(PubMed)

#Herbal #Comfrey Inhibits Back Pain Associated with the Production of Proinflammatory Cytokines, Researchers Show

Kyle J. Norton

Myalgia is a group of diseases associated with muscle pain.
Most common types of myalgia are
* Systemic lupus erythematosus

The systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the body's immune system abnormal function that attacks healthy tissue in many parts of the body, inducing symptoms of severe fatigue, joint pain, swelling, and headaches.

*Systemic sclerosis
Systemic sclerosis (SSc) is an autoimmune disease of the connective tissue that may be misdiagnosed as rheumatoid arthritis. According to Dr. Horimoto AM and Dr. Costa IP, arthritis, clinically observed, maybe a feature often found in a patient with Systemic sclerosis, often leading to early misdiagnosis with rheumatoid arthritis (RA).

The most common symptoms of systemic sclerosis are hair loss, calcium deposits, or white lumps under the skin, small, dilated blood vessels under the skin's surface and joint pain.
* Polymyositis

Polymyositis (PM) is a type of chronic inflammation of the muscles associated with dermatomyositis and inclusion body myositis.

The most common system of polymyositis is muscle pain and stiffness, muscle weakness, particularly in the belly (abdomen), shoulders, upper arms, and hips, and joint pain and stiffness.

The most common causes of myalgia are overuse, injury, or strain of muscles. However, myalgia can also be caused by diseases, medications, and in some, it is a response to vaccination.

Conventionally, most cases of myalgia are treated by over-the-counter medications such as Tylenol (acetaminophen) or nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, and naproxen

Comfrey is a perennial plant in the genus of Symphytum, belonging to the family Boraginaceae, native to Europe. It has been used in herbal and traditional medicine to ease excessive bleeding or on open wounds, relieve pain and swelling, treat circulation issues, reduce cholesterol, etc.


In finding a potential compound for the treatment of diseases associated with chronic pain, researchers investigated the effectiveness and tolerability of the topical Symphytum product Traumaplant (Harras Pharma Curarina, München, Germany) (10% active ingredient of a 2.5:1 aqueous-ethanolic pressed concentrate of freshly harvested, cultivated comfrey herb [Symphytum uplandicum Nyman], corresponding to 25 g of fresh herb per 100 g of cream) in the treatment of patients with myalgia (n=104) were tested against a 1% reference product (corresponding to 2.5 g of fresh comfrey herb in 100 g of cream; n=111).

According to the results from the primary efficacy parameter in this double-blind, reference-controlled, randomized, multicenter study of 215 patients with pain in the lower and upper back and motion and the. secondary efficacy parameters included pain at rest, pain on palpation, and functional impairment, high concentrations of the treatment product showed a significant amelioration of pain on active motion (P<5 x 10 -9 ), pain at rest (P<.001), and pain on palpation compared to the reference product which was clinically highly relevant.

The high-concentration product exerted a significantly better global efficacy and faster onset of effects.

Tolerability of the highly concentrated study product was good to excellent in all patients.

Based on the results, researchers said, "Study results confirm the known anti-inflammatory and analgesic effects of topical (Symphytum cream. As a new finding, applicability in certain forms of back pain can be concluded".

Taken altogether, Comfrey combined with other herbal medicine for the treatment of myalgia, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Topical symphytum herb concentrate cream against myalgia: a randomized controlled double-blind clinical study by Kucera M1, Barna M, Horàcek O, Kàlal J, Kucera A, Hladìkova M. (PubMed)

#Healthyfood #Strawberries Fruit #Methanolic Extract Inhibits the Risk of Leukemia (CEM) through Its Cytototic Activity, Researchers say

Kyle J. Norton

Scientists may have found a whole food that contains abundantly bioactive compounds for the prevention and treatment of leukemia with no side effects, some studies suggested.

Leukemia is a medical and chronic condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system or the body's blood-forming tissues.

Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

The causes of leukemia are unknown. However, the most common risk factors associated with the onset of the disease include radiation exposure, treatment chemotherapy for cancer, smoking, family history of leukemia, and exposure to certain chemicals such as benzene.

Genetic preposition, according to some researchers, also plays a critical role in the prevalent risk of leukemia.

Dr. Nazanin Heidari, the lead scientist in the investigation of the genetic impact in the risk of leukemia wrote, "Epigenetic and genetic alterations are two mechanisms participating in leukemia, which can inactivate genes involved in leukemia pathogenesis or progression".


The team continued, inactivation of the genes ASPP1, TP53, IKZF1, and P15, have been correlated with poor prognosis in acute lymphoid leukemia (ALL), chronic lymphoid leukemia (CLL), chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML), respectively. And abnormal genes specifically involved in leukemogenesis such as chromosomal translocations as well as genetic or epigenetic alterations, are involved in leukemogenesis.


Therefore, people who carry the mutated or inactive genes are at an increased risk of the condition.

Strawberry is a genius of Fragaria × ananassa belongs to the family Roseaceae. The fruits have been grown all over the world with a suitable climate for commercial profits and for health benefits.

The major chemical compounds of strawberry include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin

In finding a natural ingredient or whole food for the prevention and treatment of leukemia (CEM), researchers at the Indian Institute of Science evaluated the consumption of berry fruits, including strawberries, against oxidative stress-mediated diseases.

In vivo, the methanolic extract of strawberry (MESB) fruits demonstrated a potential activity against leukemia (CEM) cell lines.

In mice models, the extract of the fruit also displayed cancer therapeutic and chemopreventive potential.

According to the tested assay, MESB induced cytotoxicity in cancer cells, irrespective of origin, through its antioxidant properties in a concentration- and time-dependent manner.


Furthermore, according to the results at the end of the experience, MESB treatment affected tumor cell proliferation by activating apoptosis with no side effects.

In-depth analysis of the effect of the extract, researchers found that MESB induces cancer cell apoptosis by enhancing the function of the tumor suppressor gene p70 in the intrinsic pathway of apoptosis bypassing the mutated tumor suppressor gene p53.

Dr. Somasagara RR, the lead author said, "Strawberry fruits possess both cancer preventive and therapeutic values".

Taken together, strawberries with abundant bioactive compounds may be considered a functional fruit for the prevention and treatment of leukemia (CEM) with no side effects.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Extracts of strawberry fruits induce the intrinsic pathway of apoptosis in breast cancer cells and inhibit tumor progression in mice by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC. (PubMed)
(2) Significance of Inactivated Genes in Leukemia: Pathogenesis and Prognosis by Nazanin Heidari, M.Sc,1 Saeid Abroun, Ph.D.,Jessika Bertacchini, Ph.D,3 Tina Vosoughi, M.D,1 Fakher Rahim, Ph.D. and Najmaldin Saki, Ph.D. (PMC)