#Lycopene Inhibits Pathways Associated with Liver Damage and Injury, According to Studies

Kyle J. Norton

The liver is the largest internal organ and the first line of the bodily toxin defense by filtering the blood from the digestive tract, before passing them to the rest of the body.

The liver also produces cholesterol that plays a critical role in building a strong cell wall, producing steroid hormones and vitamin D, and aiding the digestive function in food absorption and detoxifying chemicals and metabolizes drugs.

The hepatoprotective or liver protective effect is a process that maintains the healthy function of the liver against harmful toxins.

Toxic hepatitis that links to exposure to alcohol, chemicals, drugs, or nutritional supplements that cause inflammation of the liver may be the most common liver toxicity in the US.

In the US, most cases of liver disease are a result of hepatitis viral infection and autoimmune diseases. Infectious viral hepatitis can produce toxins to protect them against the antioxidant enzymes produced by the host body and prevent the attack of the systematic immune response.

Symptoms of liver diseases include jaundice, abdominal pain, and swelling, swelling in the legs and ankles, itchy skin, dark urine, pale stool color, and a tendency to bruise easily.

According to the statistic from the Canadian liver foundation, approximately, one in ten Canadians, or more than three million people, have some form of liver disease.


Believe it or not, chronic hepatitis B and C, alcoholic liver disease, non-alcoholic fatty liver disease, and liver cancer account for 95% of deaths in patients with liver disease.


Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

In finding a potential compound for the prevention of liver injury, researchers examined the liver-protective effects of lycopene.

The study included BALB/c male mice divided into three equal groups: control, Concanavalin A (Con A), and Con A and lycopene the control group mice received the only vehicle by intraperitoneal injection, the Con A group mice were given Con A, and group mice received Con A and lycopene.

The Mice group treated by Con A showed significant liver damage observed by elevated levels of oxidative stress markers such as Con A administration increased histopathological damage, and the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT).

Furthermore, Con A also stimulated the production of pro-inflammatory cytokines such as interleukin (IL)-6, and immune response pro-inflammatory cytokines such as interferon (IFN)-γ and tumor necrosis factor (TNF)-α.

According to the analysis of the effect of lycopene on the Con A and lycopene group, all parameter associated with liver damage induced by Con A was significantly reduced by the administration of lycopene.

More importantly, lycopene not only inhibited the negative effect of Con A on liver injury but also promoted liver cell viability and cell growth.


In other words, lycopene processed anti-liver toxicity activity.

Based on the findings, researchers said, "The results of this study revealed that lycopene might be a useful hepatoprotective agent for reducing increased proinflammatory cytokine levels, and for increasing cell viability and cell growth".

Taken together, lycopene found in tomatoes may be considered a supplement for the promotion of liver protection, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hepatoprotective and antioxidant effects of lycopene in acute cholestasis by Tokaç M, Aydin S, Taner G, Özkardeş AB, Yavuz Taşlipinar M, Doğan M, Dündar HZ, Kiliç M, Başaran AA, Başaran AN. (PubMed)
(2) The hepatoprotective effect of lycopene on Con A-induced liver injury in mice by Shimizu Y, Mashima-Nemoto T, Hazawa M, Taira Y, Taira I, Ishida I, Isoda K. (PubMed)

Topical Cream with #Curcumin Found in #Turmeric Modulates Activites Associated with #Skin Photo-Damage, Researchers Say

Kyle J. norton

Photodamage is a type of skin damage caused by long-term exposure to sunlight or tanning beds.
Photodamage skin is one most common forms of skin damage in the US, due to misunderstanding the benefits and adverse effects of light exposure.

Believe it or not, a quarter of lifetime sun exposure occurs before the end of the teenage years. Most cases of photo skin damage can also stimulate some unwanted skin conditions, including advanced aging or wrinkling, uneven skin, hyperpigmentation, telangiectasias, actinic keratoses liver, and age spots.


In severe cases, long-term photodamage skin can also lead to skin cancer. More people in the US are diagnosed with skin cancer each year than all other cancers combined.


According to the statistic, 1 in 5 Americans will develop skin cancer by the age of 70.

Conventionally, most cases of early-stage and mild damage to the skin are treated by topical Levulan which removes scaly patches of actinic keratoses from your skin.

However, Laser surgery may be necessary, if the topical fails.

Dr. Jee SH, the lead scientist in the examination of the risk of photodamaged skin in the risk of skin cancer wrote, "Some workers in paraquat manufacturing, exposed to bipyridines, have developed pigmentation and keratosis on sun-exposed skin".

And, "This pathologic study proves that all the lesions showed either photodamage or skin cancer. The strong trend in the correlation between the severity of photodamage and exposure to bipyridine leads to speculation about the synergistic role of bipyridine exposure and the solar effect in causing these malignant and premalignant skin lesions".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.


The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the concerns of Ultraviolet B (UVB) irradiation in inducing skin photo-damage associated with the onset of a sunburn, erythema, photoaging, and photocarcinogenesis, researchers evaluated the protective effects of curcumin against acute photo-damage.

In hairless mice, topical application of curcumin exerted a kin-protective effect by significantly inhibiting acute UVB (540 mJ cm-2, for 3 successive days)-induced inflammatory cells, collagen accrementition derangement, and lipid peroxidation.

Additionally, the topical cream with curcumin also stimulated the NF-E2-related factor 2 (Nrf2) nuclear accumulation involved in skin defense on uncovered (Uncv) hairless mice skin.

In vitro, treatment of HaCaT cells with curcumin significantly attenuated acute UVB (300 mJ cm-2 ) tissue damage in releasing lactate dehydrogenase release (LDH) into the bloodstream.

Levels of intracellular reactive oxygen species production and DNA damage are also inhibited by the injection of curcumin by activating the expression of phase II detoxifying enzymes and promoting DNA repair activity.

In an additional analysis of the skin protective activity of curcumin, researchers found that The photoprotective effect provided by curcumin was potentially associated with modulation of the Nrf2-factor associated with antioxidant defense.

In order to reveal more information about the effects of turmeric anti-skin damage, researchers looked into the turmeric and turmeric-containing polyherbal combination tablets versus placebo on facial redness.

The prospective, double-blind, randomized pilot study included 33 healthy participants were recruited from the dermatology clinic at the University of California, Davis and nearby community from 2016 to 2017 receive one of three interventions (placebo, turmeric or polyherbal combination tablets) and were told to take the intervention tablets by mouth twice daily for 4 weeks.

According to the results, the polyherbal combination group had a significant decrease in redness of 40% compared to baseline (P = 0.03) compared to that of placebo and turmeric groups with no statistically significant changes in image analysis-based facial redness.

Based on the findings, researchers said, "Polyherbal combination tablet supplementation improved facial redness compared to the turmeric or placebo".

Taken together, turmeric processed a high amount of bioactive compound curcumin used alone or combined with other phytochemicals may be used for the prevention of skin photo-damage, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective Effect of Curcumin Against Acute Ultraviolet B Irradiation-induced Photo-damage by Li H1, Gao A1, Jiang N1, Liu Q1, Liang B1, Li R1, Zhang E1, Li Z1, Zhu H. (PubMed)
(2) Dietary supplementation with turmeric polyherbal formulation decreases facial redness: a randomized double-blind controlled pilot study by Vaughn AR1, Pourang A2, Clark AK2, Burney W2, Sivamani RK. (PubMed)
(3) Photodamage and skin cancer among paraquat workers by Jee SH1, Kuo HW, Su WP, Chang CH, Sun CC, Wang JD. (PubMed)

#Cinnamon Down-Regulates the Normal Physiological Processes Associated with the Onset of #CervicalCancer, Studies Find

Kyle J. Norton


Cinnamon may be the best wholefood medicine for the prevention, management, and treatment of cervical cancer, some scientists suggested.

Cervical cancer is a chronic medical condition characterized by irregular and disordered cell growth in the cervical tissue. In the beginning, cancer starts in the cell of the cervical lining. After completely colonizing the cervix, malignant cells may travel a distance away through lymph and blood to infect other healthy tissue and organs.

According to the statistic, every year approximately, over 13,000 women in the United States are diagnosed with invasive cervical cancer.

Although the incidence rates for the disease dropped by 50% between 1975 and 2014 due to an increase in screening, cervical cancer still causes over 4,170 deaths this year.

The 5 years survival rate for women diagnosed in the early stage of invasive cervical cancer is 92%. However, in the advanced stage, when cervical cancer has spread to a distant part of the body, the 5-year survival rate is 17%.

The exact causes of cervical cancer are unknown, However, being infected by human papillomavirus (HPV) infection due to having sex with men who carry the virus is a major cause of the disease.


Furthermore, women who have many sexual partners, are smoking, use birth control pills (oral contraceptives) for the long-term and engage in early sexual contact are associated with an increased risk of cervical cancer.


Women, in the early stage of cervical cancer, may not experience any symptoms. If you are having persistent symptoms of abnormal vaginal bleeding, increased vaginal discharge, bleeding after menopause, and severe pain during sex and pelvic pain, please check with your doctor to rule out the possibility of cervical cancer.

Cinnamon is a spice derived from the inner bark of a tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the family Lauraceae.

The spicy herb has been used in herbal and traditional medicine as an anti-fungal and bacteria level, to improve the reproductive organ, prevent flatulence and intestinal cramping, and treat indigestion, diarrhea, bad breath, headache, migraine, etc.

According to the Manipal University, Eugenol, a potential chemopreventive agent, one of the components of cinnamon possesses antiseptic, analgesic, antibacterial, and anticancer properties in the expression of apoptosis and inflammation against cervical cancer cell lines.

In the SiHa cancer cell line, established from cancerous tissues of the cervix uteri, methanol extracts of Gymnema sylvestre (GS) leave and Cinnamomum zeylanicum (CZ) bark exhibited dose-dependent cytotoxicity in inducing apoptosis.

Other researchers suggested that the effects of cinnamon against tumor activity, particularly in cervical cancer cell line SiHa may be the result of the reduced number of colonies, and the risk of migration potential through down-regulated normal physiological processes.

Dr. Kwon HK, the lead researcher at the Gwangju Institute of Science and Technology, insisted, Cinnamomum cassia bark,.. containing several active components such as essential oils, expressed anti-tumor effect via enhanced pro-apoptotic and inhibited pro-inflammatory activities, in vitro, and in vivo mouse melanoma model.

In fact, the potential anti-tumor effects of cinnamon may be due to the activities that suppress cancer progression by increasing the levels of cytolytic molecules and functioning.

Although the whole herb medicine may be a potential agent for reduced risk and treatment of cervical cancer, oral use of cinnamon should be taken with care and only prescribed by a herbalist.

Additional data collection on large example size and multi-center studies performed with human consumption of the whole food cinnamon during the course of the disease will be necessary to complete the picture of the spicy herb anti-cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Eugenol enhances the chemotherapeutic potential of gemcitabine and induces anticarcinogenic and anti-inflammatory activity in human cervical cancer cells by Hussain A1, Brahmbhatt K, Priyani A, Ahmed M, Rizvi TA, Sharma C.(PubMed)
(2) Biomolecule-loaded chitosan nanoparticles induce apoptosis and molecular changes in cancer cell line (SiHa) by Sujima Anbu A1, Velmurugan P2, Lee JH3, Oh BT4, Venkatachalam P5. (PubMed)
(3) Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential by Koppikar SJ1, Choudhari AS, Suryavanshi SA, Kumari S, Chattopadhyay S, Kaul-Ghanekar R.(PubMed)
(4) Cinnamon extract induces tumor cell death through inhibition of NF-kappaB and AP1 by Kwon HK1, Hwang JS, So JS, Lee CG, Sahoo A, Ryu JH, Jeon WK, Ko BS, Im CR, Lee SH, Park ZY, Im SH. (PubMed)
(5) Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells by Kwon HK1, Jeon WK, Hwang JS, Lee CG, So JS, Park JA, Ko BS, Im SH.(PubMed)

#Emodin Found in #Herbal #CascaraSagrada Inhibits Pancreatic Cancer By Promotinfg Apoptosis and Suppressing Angiogenesis

Kyle J. Norton

Scientists may have found a functional herb bioactive compound which processes anti-pancreatic cancer activity with no side effects, some scientists suggested.
Pancreatic cancer is a medical and chronic condition characterized by irregular cells growth in the tissue of the pancreas.

In the early stage, pancreatic cancer starts on the cells of the surface of the inner lining of pancreatic tissue. At the advanced stage, cancerous cells of the pancreas can travel a distance away to invade other healthy tissue and organs.

The exact causes of the alternation of DNA of pancreatic cells are unknown. However, epidemiological studies suggested that genetic preposition and acquired gene mutations are associated with the increased incidence of cancer.

Some researchers suggested long-term use of tobacco, being overweight and obese, exposure to workplace chemicals, age, gender and family history are some prevalent risk factors of pancreatic cancer.

According to the statistic, pancreatic cancer is the eighth most common cancer in women and the fourth leading cause of cancer death in men and women. cancer accounts for 7% of all cancer deaths.

The 5 years survival rate at stage 1 and 2 is 61% and 52% respectively.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America.

The herbal's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing effect.

Besides the main compound of anthraquinones, the herb also contains anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.

In the study to reaffirm the Emodin anti-pancreatic cancer effect through inducing apoptosis of pancreatic cancer cells and inhibiting tumor growth, researchers at the Zhejiang University School of Medicine, launched an investigation to find out whether emodin could inhibit the angiogenesis of pancreatic cancer tissues and its mechanism.
In vitro and in vivo Emodin inhibited pancreatic cancer cell growth, induced apoptosis, and enhanced the anti-tumor effect of gemcitabine on pancreatic cancer cells by inhibiting the activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), the protein in response to cellular survival

Emodin inhibited tumor angiogenesis in vitro and in implanted pancreatic cancer tissues, decreased the expression of angiogenesis-associated factors and reduced eNOS phosphorylation in cell proliferation.

However, Emodin had no effect on VEGFR expression in vivo.

Dr. Lin SZ, the lead author said, "Emodin has a potential anti-tumor effect on pancreatic cancer via its dual role in the promotion of apoptosis and suppression of angiogenesis".

Additionally, in the examine the effects of an X-linked inhibitor of apoptosis (XIAP) and NF-κB in chemotherapy resistance in pancreatic cancer, researchers conducted an investigation of SW1990 cells treated by sodium chloride, gemcitabine, emodin or their combination (gemcitabine plus emodin).

The combination therapy of gemcitabine plus emodin) is more effective in inducing a significantly inhibited SW1990 cell growth and a higher percentage of apoptosis than monotherapy.

Gemcitabine upregulated the expression of XIAP and NF-κB, while emodin or emodin plus gemcitabine downregulated them compared to the control group in vitro.

In SW1990 cells established orthotopic pancreatic tumor models in nude mice. The combination of emodin and gemcitabine showed a significant reduction in the tumor to tumor (T/NT) ratio, Standardized uptake value (SUV) and tumor weight compared to monotherapy.

Dr. Wang ZH, the lead author after taking into account of co and confounders wrote:" emodin enhances the antitumor effect of gemcitabine in SW1990 pancreatic cancer in vitro and in vivo, which may be via the downregulation of NF-κB expression, thus inhibiting the expression of XIAP.".

Taken altogether, herbal Cascara sagrada process high amount of bioactive ingredient Emodon may be considered a function in the prevention and an adjunct therapy combined with chemo intervention of treatment of pancreatic cancer, pending to the results of large example size and multi-center studies.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
1. Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis by Lin SZ, Wei WT, Chen H, Chen KJ, Tong HF, Wang ZH, Ni ZL, Liu HB, Guo HC, Liu DL. (PubMed)
2. Enhanced antitumor efficacy by the combination of emodin and gemcitabine against human pancreatic cancer cells via downregulation of the expression of XIAP in vitro and in vivo by Wang ZH, Chen H, Guo HC, Tong HF, Liu JX, Wei WT, Tan W, Ni ZL, Liu HB, Lin SZ.(PubMed)
3. [Toxic hepatitis following consumption of the herbal medicinal product Cascara Sagrada].[Article in Danish]" by Jacobsen C, Semb S, Kromann-Andersen H(PubMed)
4. "Cascara sagrada-induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity" by Nadir A, Reddy D, Van Thiel DH. (PubMed)
5. "Occupational respiratory allergic disease induced by Passiflora alata and Rhamnus purshiana" by Giavina-Bianchi PF Jr, Castro FF, Machado ML, Duarte AJ. (PubMed)

#Healthyfood #Carrots Inhibit Parameters Associated with the Onset of #OralDiseases, According to Studies

Kyle J. Norton

Scientists may have found a phytochemical isolated from carrots which process a significant potential in acting as a nonsurgical aid in the treatment of oral diseases, some studies suggested.
Oral diseases are groups of a medical condition, including dental cavities, periodontal (gum) disease, oral cancer, oral infectious diseases, trauma from injuries, and hereditary lesions.

Some researchers suggested that oral health is an important part of your overall health.

The Ireland Dental Health Association in the article Links between oral & general health wrote, "A healthy mouth enables not only nutrition of the physical body but also enhances social interaction and promotes self-esteem and feelings of well-being" and "Bacteria from the mouth can cause infection in other parts of the body when the immune system has been compromised by disease or medical treatment".

Therefore, maintaining healthy oral health may result in reducing the risk which links oral disease to other health problems such as diabetes, heart disease, and stroke.

Truly, there are some tips that may help you to prevent oral health problems, including visiting your dentist one to two times a year for a cleaning and checkup. brush your teeth with fluoride toothpaste a minimum of two times per day, replace your toothbrush or toothbrush head every three to four months, and floss at least once per day, according to the article published on Health Line.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.

In the aim to find a natural pigment with potential to improve the oral health, researchers at the Swami Devi Dyal Hospital and Dental College conducted an experiment on some of the various classes of pigments in nature, particularly, the pigment lycopene, a red plant pigment found in tomatoes, apricots, guavas, carrots, watermelons, papayas, and pink grapefruits, with tomatoes being the largest contributor to the dietary intake of humans.

Application of lycopene not only exhibits higher antioxidant activity through the ability as singlet oxygen quenching phytochemical, but also exerts a multifunctional role as a nonsurgical aid in the treatment of oral diseases like leukoplakia, oral submucous fibrosis, lichen planus, oral squamous cell carcinoma, and also prevents the destruction of periodontal tissues.

The findings suggested adding 1 or 2 portions of tomatoes into your daily diet can provide absolute protection for your oral health.

Furthermore, in the examine the link between chronic periodontitis (CP), a multifactorial infecto-inflammatory disease caused by the interaction of microbial agents present in the biofilm and oxidative stress (OS), an imbalance of the ratio between free radicals and antioxidant enzymes produced by the host body, researchers at the Federal University Rio Grande do Sul conducted a randomized, controlled, double-blind or blind studies to evaluate the effect of selected antioxidant
in chronic periodontitis patients.

Antioxidant including in the study are lycopene, vitamin C, vitamin E, capsules with fruits/vegetables/berries.

In the final report of the experiment, researchers indicated that only lycopene and vitamin E demonstrated statistically significant improvement when compared to a control group in terms of periodontal parameters.
These results were observed through oxidative stress patterns throughout the study. As only lycopene and vitamin E showed a reduction in the levels of oxidative stress compared to others.


Moreover, in the evaluation of the effect of lycopene along with routine scaling and root planing in terms of changes in clinical parameters and levels of circulating tumor necrosis factor-alpha (TNF-α), salivary interleukin 1beta (IL-1ß), and uric acid in chronic periodontitis, researchers launched a randomized, placebo-controlled, parallel design, double-blinded trial in a total of 42 subjects/

Out of 42 subjects assigned to the test group (n = 21) received 8 mg lycopene/day and the placebo group (n = 21) along with adjunctive scaling and root planing. Patients were monitored at baseline and at 2 months after therapy.

At the end of the study, researchers found that test group (Lycopene) showed better results after therapy compared to the placebo group with all assays, including Periodontal parameters regarding plaque index (PI), modified gingival index (MGI), bleeding on probing (BOP).

Although the serum TNF-α value, the pro-inflammatory cytokine was not statistically significant, it, however, showed an improvement compared to the placebo group.

Taken together, tomato and carrot-processed abundant phytochemical lycopene may be an adjunct therapy combined with conventional medicine for the prevention and treatment of oral diseases.

Therefore, adding 2 or 3 portions of tomatoes or carrots or intake of lycopene supplement, according to the guideline on a regular basis may give you perfect breath and oral health.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Role of Lycopene in Preventing Oral Diseases as a Nonsurgical Aid of Treatment by Gupta S1, Jawanda MK2, Arora V3, Mehta N4, Yadav V(PubMed)
(2) The impact of antioxidant agents complimentary to periodontal therapy on oxidative stress and periodontal outcomes: A systematic review by Muniz FW1, Nogueira SB2, Mendes FL3, Rösing CK4, Moreira MM5, de Andrade GM6, Carvalho Rde S(PubMed)
(3) The adjunctive use of systemic antioxidant therapy (lycopene) in nonsurgical treatment of chronic periodontitis: a short-term evaluation by Arora N1, Avula H, Avula JK(PubMed)

#ManukaHoney Decreases the Levels of MDA Associated with the Risk of Ulcers, Researchers Show

Kyle J. Norton

Honey may be the next pharmaceutical target to identify the single ingredient medicine for the treatment of diseases associated with oxidative stress, some scientists suggested.

Oxidative stress is a result of an imbalance in the ratio of free radicals and antioxidants in the body.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to their nature to become stable, free radicals readily donate or steal an electron from other molecules, leading to the chain of domino effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

This chain of reaction is the cause of oxidative stress, a condition associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.

Overexpression of free radicals is known to cause damage in contributing to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer.
Antioxidants, on the other hand, are stable molecules with a unique function in the inhibition of oxidation.

Dr. V. Lobo, the lead author in the study "Free radicals, antioxidants, and functional foods: Impact on human health" wrote, " A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues", and

"Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence the application of an external source of antioxidants can assist in coping with this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health".

These results suggested that regardless of the causes of the overexpression of free radicals, intake of dietary sources of antioxidants from a supplement, herbs, fruits, and vegetables can be beneficial in restoring the healthy ratio of free radicals and antioxidants and preventing the onset of oxidative stress.

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered healthy sweet food for replacing the use of white sugar and artificial sweetener.

In order to understand the honey antioxidant activity which has been under intensified study by the science community, a joint study led by the researchers conducted was conducted in an animal model.

Ethanol-induced gastric ulcers in rats were randomly assigned to control, ethanol (ulcer), omeprazole, and manuka honey.

Honey-treated rats displayed a clinically significant decrease in the ulcer index by completely protecting the mucosa from lesions and preserving gastric mucosal glycoprotein.

Application of manuka honey also decreased gastric mucosal MDA, the marker of oxidative stress and plasma TNF-α, IL-1β, and IL-6 concentrations, the set of proinflammatory cytokines produced by the ethanol injection.

The results were attributed to the manuka honey in stimulating the production of antioxidant enzymes which were suppressed by the injection of ethanol in the tested rats.

The finding suggested that manuka honey exerted a strong antioxidant activity by balancing the ratio of free radicals and antioxidant enzymes in the treatment group.

In other words, manuka honey inhibited the oxidative stress caused by the overexpression of free radicals in the initiation of the onset of the ulcer.

Further differentiation to reaffirm the effects of manuka honey in the inhibition of gastric ulcer in the rat model, researchers examined three different concentrations of honey applied to the tested rats.

During the experiment, researchers found that all 3 different concentrations display a strong effect in It reducing the mucosal myeloperoxidase activity, lipid peroxidation (MDA), and the inflammatory cytokines (TNF-α, IL-1β, and IL-6) compared to the untreated control group.

In other words, manuka honey protects the rat stomach by inhibiting the overexpression of free radicals and pro-inflammatory cytokines in inducing oxidative stress.

Application manuka honey also showed a significant increase in enzymatic (GPx and SOD) and non-enzymatic (GSH) antioxidants which were reduced due to ulcer and levels of the anti-inflammatory cytokine IL-10.

The Flow cytometry assay also indicated that treatment of rats with manuka honey has normalized cell cycle distribution and significantly lowered apoptosis in gastric mucosa.

The information collected strongly supports the use of manuka honey for the treatment of chronic ulcers and preservation of mucosal glycoproteins.
Dr. Almasaudi SB wrote in the final report, "Its (manuka honey) effects are due to its antioxidant and anti-inflammatory properties that resulted in a significant reduction of the gastric mucosal MDA, TNF-α, IL-1β, and IL-6 and caused an elevation in IL-10 levels.


Taken together, there is no doubt that manuka honey high in antioxidants can be considered a functional food for the prevention and combined with the primary medicine for the treatment of diseases associated with oxidative stress.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Almasaudi SB1, El-Shitany NA2, Abbas AT3, Abdel-dayem UA4, Ali SS5, Al Jaouni SK6, Harakeh S. (PubMed)
(2) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
(3) Protective effects of Manuka honey on LPS-treated RAW 264.7 macrophages. Part 2: Control of oxidative stress induced damage, increase of antioxidant enzyme activities and attenuation of inflammation by Gasparrini M1, Afrin S1, Forbes-Hernández TY1, Cianciosi D1, Reboredo-Rodriguez P2, Amici A1, Battino M1, Giampieri F3. (PubMed)
(4) The inflammation theory of diseas. The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment by Philip Hunter. (PubMed)

#Curcumin Found in #Turmeric Inhibits Parameters Associated with the Onset of #DiabeticCardiomyopathy, According to Studies

Kyle J. Norton

Diabetic cardiomyopathy is a complication found in patients with diabetes associated with reducing the heart function in circulating blood through the body, leading to heart failure and increased accumulation of fluid in the lungs.
Diabetic cardiomyopathy is classified into different types, depending on the damage that has been affected, including
* Microangiopathy is a disorder that affects small blood vessels, leading to impaired myocardial blood flow reserve.

* Autonomic neuropathy is a disorder that affects the nerves that manage everyday body functions, leading to abnormal blood pressure, and heart rate.


* Endothelial dysfunction is a disorder associated with the damage of vascular endothelium. The condition is considered an early event of cardiovascular disease.

The most common causes of diabetic cardiomyopathy are myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia.

At the early stage, most patients with diabetic cardiomyopathy are asymptomatic. However, mild left ventricular diastolic dysfunction with little effect on ventricular filling and concomitant hypertension or coronary artery disease has been found to be the early indication of diabetic cardiomyopathy in patients with diabetes.

Epidemiologically, the most common risk factors that increase the risk of diabetic cardiomyopathy. are insulin resistance, hyperinsulinemia, and hyperglycemia.

Conventionally, as of today, there is no effective treatment for diabetic cardiomyopathy. Medication used for the treatment of the condition is focusing on glycemic control and management of heart failure symptoms.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential ingredient for the treatment of diabetic cardiomyopathy(DCM), researchers examined the effect of curcumin on modulating DCM and the mechanisms involved.

The study included an experimental diabetic rat model induced by a low dose of streptozotocin(STZ) combined with high energy intake in rats, followed by curcumin orally administrated at a dose of 100 or 200 mg · kg(-1) · d(-1), respectively.

Before the treatment of curcumin, induced DCM rats showed a declined systolic myocardial performance associated with myocardial hypertrophy and fibrosis accompanied by metabolism abnormalities, aberrant myocardial enzymes, and increased AGEs (advanced glycation end-products) accumulation.
Increased levels of ROS and depletion of antioxidant enzymes were also found in the rat before pretreatment with curcumin, observed by increased oxidative stress markers.

Furthermore, levels of pro-apoptotic proteins and proinflammatory cytokines were also found to significantly increase in DCM rats.

After the injection of curcumin, researchers found that remarkably, the bioactive compound attenuated myocardial dysfunction, cardiac fibrosis, AGEs accumulation, oxidative stress, inflammation, and apoptosis in the heart of diabetic rats.

In other words, curcumin protected the heart of DCM rats against the onset of diabetic cardiomyopathy(DCM).

Based on the results, researchers said, "These results suggest that curcumin may have great therapeutic potential in the treatment of DCM, and perhaps other cardiovascular disorders, by attenuating fibrosis, oxidative stress, inflammation, and cell death".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered a supplement for the prevention and treatment of diabetic cardiomyopathy, pending the confirmation of the larger sample size and multicenter human study.


Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin, A Polyphenolic Curcuminoid With Its Protective Effects and Molecular Mechanisms in Diabetes and Diabetic Cardiomyopathy by Zheng J1, Cheng J2, Zheng S3, Feng Q3, Xiao X. (PubMed)
(2) Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats by Yu W1, Wu J, Cai F, Xiang J, Zha W, Fan D, Guo S, Ming Z, Liu C. (PubMed)