#Herbal #Chastetreeberry Exerts an Osteoprotective Effect in Males, According to Studies

Kyle J. Noton

Chaste tree berry is found to processability in reduced of MALE osteopenia turnover, the early sign of osteoporosis, a renowned institution study reported.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.

In a total of 60, 3-month-old male rats orchidectomized and divided into five groups with each group either receiving soy-free food (C), estradiol (E), testosterone (T) or Vitex agnus castus in different concentrations (AC high/AC low) for 12 weeks, rats treated with Vitex agnus castus at highest dose displayed a recover of 88.4% of the trabecular bone area, 80.7% of a trabecular number and 66.9% of the number of trabecular nodes compared with other administrations.


The study also found out that Vitex agnus castus is more protective in treating osteoporosis in the male population, compared to female counterparts.

Dr. Sehmisch S, the lead author said, " Vitex agnus castus demonstrated osteoprotective effects in males. It preserves the cortical as well as the trabecular bone and might be a safe alternative for HRT".

Furthermore, In the study to compare a group of animals (n = 8) treated subcutaneously (s.c.) with 60 mg/kg of Vac essential oil once a day for 3 weeks and control animals (n = 8) received sterile olive oil s.c. by the same schedule, Vitex agnus-castus L. (Vac) essential oil-treated group also exerted a significant bone metabolism in 16-month-old male Wistar rats.

The osteoporosis protection can be observed through the lower Serum osteocalcin (OC) and calcium (Ca2+) in Vitex agnus-castus L. (Vac) essential oil and decreased bone turnover treated group in compared control in middle-aged male rats.

Taken together, Chaste tree berry showed strong support in the reduced early onset of osteoporosis of male gander through improved bone metabolism and calcium status, but further large size and multi centers studies are necessary to validate this potency.


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Sources
(1) Vitex agnus castus as prophylaxis for osteopenia after orchidectomy in rats compared with estradiol and testosterone supplementation by Sehmisch S1, Boeckhoff J, Wille J, Seidlova-Wuttke D, Rack T, Tezval M, Wuttke W, Stuermer KM, Stuermer EK. (PubMed)
(2) Vitex agnus-castus essential oil affects thyroid C cells and bone metabolism in middle-aged male rats (Researchgate)

#Lycopene-Loaded Whey Protein Isolate Nanoparticles (LYC-WPI-NPs)Exerts Anti Cancer Activity by Secreasing Tumor Proliferation, and Increasing the Survival Rate, Researchers Say

Kyle J. Norton

Cancer is a class of chronic and medical conditions caused by cell growth irregularly in the tissues of the body.
Cancer can be classified into
* Primary cancer or original cancer is a tumor at the original site where it first arose where tumor progression began and proceeded to yield a cancerous mass.

* Secondary metastasis is tumor spread from primary cancer.

Most cases of cancer begin in the cells on the surface of the inner lining of the organs' tissues. For example, breast cancer starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

Under normal circumstances, cell growth is a natural process without even notice, every day millions of cell grow to replace millions of dead cells and to keep our body in balance and healthy.

Sometimes, acceleration of cell growth is necessary to prevent further damage to the body tissues and organs, such as cut, injuries, etc., but after fulfilling their purposes, the growth of cells are back to a normal rate again due to our body growth inhibitors.

However, in cancer, mutated cells can grow indefinitely by accelerating cell division rates or inhibiting normal controls on the system, such as cell cycle arrest or programmed cell death, leading to the formation of cell mass or tumor.

The exact causes of cancer are unidentified. Researchers can not explain why people with the same health conditions and family history in the same family, are prone to cancer development while others do not.

According to the statistic, In 2018, approximately 1,735,350 new cases of cancer were diagnosed in the United States. The diseases also cause the death of 609,640 Americans in the same year.

Believe it or not, cancer mortality is higher among men than women (196.8 per 100,000 men and 139.6 per 100,000 women), according to the National Cancer Institute.

Tomato is red, edible fruit, genus Solanum, belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In finding a natural ingredient for the prevention and treatment of cancer with no side effects researchers examined several HDACi of natural and dietary origin such as tomatoes against cancer development.

Where histone deacetylase inhibitors (HDACi) regulated the activity of histone deacetylase enzymes (HDACs) have been used in cancer treatment either alone or in combination with other chemotherapeutic drugs/radiotherapy.

According to the differential, HDACi exhibited antitumor effect by the activation of cell cycle arrest, induction of apoptosis and autophagy, angiogenesis inhibition.

Furthermore, the cancer inhibition of HDACi is also found in increased reactive oxygen species generation that causes oxidative stress, and mitotic cell death in cancer cells.


In order to reveal more information about tomatoes' anti-cancer properties, scientists investigated lycopene-loaded whey protein isolate nanoparticles (LYC-WPI-NPs) anti-cancer activity.

The percent lycopene entrapment of prepared LYC-WPI-NPs was estimated in the range to 50 and 65%.

The WPI-NPs was found to enhance the oral bioavailability and absorption of lycopene by controlling its release from nano-formulation and lymphatic pathways.

Moreover, lycopene improved the biopharmaceutical attributes of lycopene and demonstrated prophylactic anticancer activity, decrease tumor proliferation, and increased the survival rate of treated animals, in the form of loaded protein nanoparticles.

Taken together, tomatoes processed with high amounts of lycopene may be considered a functional food for the treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy by Singh AK1, Bishayee A2, Pandey AK. (PubMed)
(2) Lycopene loaded whey protein isolate nanoparticles: An innovative endeavor for enhanced bioavailability of lycopene and anti-cancer activity by Jain A1, Sharma G2, Ghoshal G3, Kesharwani P4, Singh B5, Shivhare US4, Katare OP. (PubMed)

#Healthyfood #Onions Inversely Are Associated with the Risk of Multiple Cancer Development, According to Studies

Kyle J. Norton


Cancer is a group of medical conditions caused by irregular cell growth in the tissues organs due to the alternation of cell DNA.

Most cases of cancer start in the cells on the surface of the inner lining of the infected tissue or argan before penetrating into the deeper layers to form a tumor.

Certain factors have been found to affect prognosis including
* The type of cancer and where it is in your body

*The stage of cancer, most often refers to the size and metastasis of cancer.

** Stage 0
Cancer is classified as Stage 0 if the cancerous cell has not penetrated in deeper tissue but on the surface of the inner lining.
** Stage I
In stage I, The cancerous cells are no longer on the surface but have invaded into deep lung lining, but still completely inside the lung.
***Stage IA1
The cancer is ≤ 3 mm (1/8 inch) deep and ≤ 7 mm (1/4 inch) wide.
**** Stage IA1: The spreading is < 3mm(1/8 inch) deep and & less than 7mm (1/4 inch) wide.
**** Stage IA2: The invasion area is ≥ 3 mm but ≤ 5 mm (about 1/5 inch) deep and & less than 7 mm (about 1/4 inch) wide.
***. Stage IB: cancer in this stage have invaded the connective tissue, & less than 5mm (1/5 inch).
**** Stage IB1: Cancer is 4 cm large (1 3/4 inches).
**** Stage IB2: Cancer is ≥ 4 cm (1 3/4 inches) but & less than 5cm (1/5 inch)

**Stage II
In stage II, the cancerous cells have spread to distant tissues but are still within the organ.

**Stage III
this stage, cancerous cells have spread to the tissues immediately surrounding the organ.

**Stage IV
In the stage, IV is the most advanced stage of cancer as cancerous cells have spread to the distant parts of the body

In this stage, cancerous cells have spread to the tissues immediately surrounding the organ.

* Cancer’s grade, low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.

* Certain traits of cancer cells include
** How cancer cell stimulates their own growth

** How cancer cells resist inhibitory signals that stop their growth

** How cancer cells inhibit programmed cell death signaling.


Some researchers also include the age, health of patients and how patients responded to previous cancer treatment

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.

With an aim to find a potential compound for the treatment of cancer, researchers examined the effect of garlic and onion on certain types of cancer.

Intake of onion is found inversely associated with the risk of cancers of the oral cavity/pharynx, larynx, renal cells, breast, ovary, and endometrium.


More precisely, people who eat onions ≥7 times/week have the OR of oral cavity/pharyngeal cancers of 0.16, laryngeal cancer of 0.17, and ovarian cancer of 0.27 compared to those who did not eat onions.

Furthermore, according to the study of cases from the Hawaii Tumor Registry and controls randomly selected from a list of Oahu residents, intake of onion was associated with decreased risk of lung cancer with the OR = 0.5 in the highest quartile of intake compared to the lowest.

In prostate cancer, the Italian study suggested that both onions and garlic did not have significantly decreased OR of prostate cancer compared to those with the lowest intake, However, increasing intake showed a trend of decreasing the ORs.

In esophageal cancer, the intake of raw garlic/onion at least one time per week has the adjusted OR of esophageal cancer of 0.2.
In colorectal cancer, the Italian and Swiss case-control studies found that both onions show a protective effect against colon cancer regardless of the amount of intake onion intake compared to non-consumers of onion.

In stomach cancer, according to the meta-analysis, consumption of large amounts of total Allium vegetables, such as garlic and onion reduced the risk of gastric cancer by comparing the highest and lowest consumption groups.

Taken together, onion may be considered a remedy for the prevention of cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Understanding Cancer Prognosis (NIH)

#KelulutHoney KH Inhibits Chemo-toxicity By Restoring the Kidney and Liver Function, Researchers Say

Kyle J. Norton

Honey may be considered an adjunct therapy combined with the chemo drug in the improvement of the drug efficacy and reduction of chemo toxicity for the treatment of cancers, some scientists found.
Cancer is a class of chronic diseases characterized by cell growth irregularly and disorderly in the tissue of specific organs, depending on the type of cancer.

Most cases of cancer are the result of the alternation of DNA in the cell located on the surface of the inner lining of an organ. Most patients may not experience any symptoms at an early stage.

However, as cancer progresses, the continued growth of tumor may cause pressure on the nearby healthy organs and nerve cells, leading to localized symptoms and severe pain.

At the 4th stage of cancer, malignant cells may metastasize to other organs a distance away from the original site.

According to the statistic from the National Cancer Institute, approximately, 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes.

In 2017, over 15,000 children and adolescents ages 0 to 19 were diagnosed with cancer and 1,790 died of the disease.
Chemo drugs are medicine used for the treatment of cancer by killing cancer cells that have been spread to other tissue or organ.

Chemotoxicity is the side effect of chemo drugs.

The most common symptoms of chemo drugs include the effect of blood-forming cells in the bone marrow, on hair follicles and cells in the mouth, digestive tract, and reproductive system, probably due to the medicine designed to kill cells indiscriminately.

According to the information from the pharmaceutical company, doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented by mankind.

The chemo drug used to treat a wide variety of cancers can kill cancer at every point in their life cycle.
Unfortunately, the drug can also damage heart cells and cause serious side effects, such as hair loss, breathlessness, feeling sick, and being easily infected.
Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered healthy sweet food for replacing the use of white sugar and artificial sweetener.

In finding a natural ingredient or whole food which processes chemopreventive properties and anti-chemo toxicity during cancer treatment, researchers evaluate the effect of Kelulut honey (KH), produced by the stingless bees from Trigona species against colon cancer induced in the animal model.

A total of 24 male Sprague Dawley rats aged 5 weeks are included in the study.
Rats were divided into 4 groups: (G1) untreated group not induced with AOM, (G2) untreated group induced with AOM, (G3) treated group induced with AOM, and (G4) treated group not induced with AOM.
Injection of AOM (15 mg/kg) was via intraperitoneal route once a week for two subsequent weeks to induce colorectal cancer.
The treatment groups were given oral administration of KH (1183 mg/kg body weight) twice daily for 8 weeks.

AOM injected group showed a significant increase in the total number of aberrant crypt foci (ACF) and aberrant crypts (AC) and crypt multiplicity and damage to liver and kidney

After treatment of KH, the AOM group displayed a reduction of crypts and chemotoxicity by restoring the liver and kidney function observed by the blood profile.

Furthermore, KH was not toxically identified by the KH-treated group not induced with AOM.

These results suggested that KH may have a potential effect on inhibiting the toxicity caused by chemotherapy and improving the chemo drugs' activity without inducing any side effects.

Moreover, on finding a natural whole food to overcome 5-fluorouracil (5-FU) therapeutic resistance and adverse toxicity in colorectal cancer, researchers looked into Manuka honey (MH), a rich source of bioactive compounds to examine its anticancer effects on human colon cancer HCT-116 and LoVo cells.

Compared to 5-FU alone, MH synergistically enhanced the chemotherapeutic effects of 5-FU, by reducing cell proliferation through the suppression of enzymes and proteins associated with the function of stimulating cancer cell multicity and activation of pathways associated with cell death programming.

Combined with chemo drug 5-FU, MH promoted the expression of antibody production and production of ROS in the induction of cytotoxicity activity against cancer cells without causing harm to the nearby cells and tissue.

This result was observed by the reducing antioxidants produced by the cancer cells and increasing oxidative stress in the tumor.

Additionally, MH also induced cancer cell apoptosis through cell cycle arrest.

The findings clearly indicated MH could be a useful preventive or adjuvant agent in the treatment of colorectal cancer with 5-FU by inhibiting toxicity and cancer cell resistance.

Taken altogether, KH and MH can be considered functional foods for the prevention and an adjunct therapy combined with the primary medicine for the treatment of cancer without inducing chemotoxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Chemopreventive Properties and Toxicity of Kelulut Honey in Sprague Dawley Rats Induced with Azoxymethane by Saiful Yazan L1, Muhamad Zali MF2, Mohd Ali R3, Zainal NA2, Esa N4, Sapuan S4, Ong YS4, Tor YS4, Gopalsamy B2, Voon FL2, Syed Alwi SS. (PubMed)
(2) Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes, and suppressing metastasis ability by Afrin S1, Giampieri F1, Forbes-Hernández TY1, Gasparrini M1, Amici A1, Cianciosi D1, Quiles JL2, Battino M. (PubMed)

#GingerProcesses Antimicrobial and Antifungal Properties Associated with #Periodontitis in Oral Cavity, According to Studies

Kyle J. Norton

Scientists may have found a pungent spice that processes the potential to inhibit microbial infection, according to studies.
Microbial infection is an infection caused by the multiplication of microbes after entering the body successfully.

The process of infection can be divided into many stages. However, most microbes that try to invade the body were killed in the acute phase of infection by the immune system response through the production of the protein associated with the pro-inflammatory cytokines.

Most people do not experience any symptoms until the microbe multiplies to the peak in its population.

Acute infection in most cases is recovered within a week or two. However, if the immune function cannot destroy all the microbes within a certain period of time, it will adapt to the new change, leading to chronic low-grade inflammatory diseases.

The chronic low-grade inflammatory state is a pathological feature of a wide range of chronic conditions, such as metabolic syndrome (MetS), non-alcoholic fatty liver disease (NAFLD), and type 2 diabetes.

The most common risk of microbial infection is a weakened immune system, particularly in the elderly.

The Institute of Medicine (US) Division of Health Promotion and Disease Prevention in examing the risk of infection in the elderly, wrote, "The implications of an aging population for health care are being widely discussed but seldom with the understanding that health promotion and disability prevention are workable concepts for people in the “second 50” years of life".

And, "Pneumonia and influenza are among the leading causes of death and morbidity from infection among older people. Safe and effective vaccines to prevent pneumonia and influenza are available and should be universally used in persons over age 50. Nosocomial (institutionally acquired) infections have a major deleterious impact on persons over 50 and require good infection control practices in hospitals and nursing homes".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural alternative for the treatment of bacterial infection examined the ginger's antimicrobial and antifungal properties associated with periodontitis in the human oral cavity

The application of ethanol and n-hexane extracts of ginger exhibited antibacterial activities that cause periodontal diseases. against three anaerobic Gram-negative bacteria, Porphyromonas gingivalis ATCC 53978, Porphyromonas endodontics ATCC 35406, and Prevotella intermedia ATCC 25611.

Two highly alkylated gingerols, such as [10]-gingerol and [12]-gingerol effectively inhibited the growth of these oral pathogens at a minimum inhibitory concentration (MIC) range of 6-30 microg/mL.

Furthermore, these 2 compounds also killed the oral pathogens at a minimum bactericidal concentration (MBC) range of 4-20 microg/mL compared to other failed compounds such as 5-acetoxy-[6]-gingerol, 3,5-diacetoxy-[6]-gingerdiol and galanolactone.

In order to reveal more information about ginger's antimicrobial activity, researchers examine the newly isolated compound including 6-paradol (1) and 6-shogaol (2) as the major antimycobacterial agents.

Injection of these isolates was found to be active against Mycobacterium chelonei, M. intracellulare, M. smegmatis, and M. xenopi (MIC 10-15 µg/ml).

The desmethyl derivative of compound (1) retained antimycobacterial activity. However, derivatives are more active against Candida albicans, compared to (1) and (2).

Interestingly, newly compound Gingerone (9)was found to be inactive against microbial activity.

Taken together, ginger processed with abundantly bioactive ingredients may be considered a natural alternative for the prevention and treatment of microbial infection, and diseases associated with micro bacterial infectious disease, pending the confirmation of a larger sample size and multicenter human infection.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria by Park M1, Bae J, Lee DS. (PubMed)
(2) Antimicrobial Activity of 6-Paradol and Related Compounds by Ahmed M Galal. (Journal, International Journal of Pharmacognosy)
(3) The Second Fifty Years: Promoting Health and Preventing Disability by The Institute of Medicine (US) Division of Health Promotion and Disease Prevention

#Methylglyoxal (MGO) From #ManukaHoney Processes Anti-influenza Viral Activity, Reserachers Reveal

Kyle J. Norton

Honey may have a profound effect in reducing the risk and treatment of influenza, some scientists suggested.
Influenza, also known as the flu, is an infectious disease caused by an influenza virus.

There are 3 types of flu influenza: A, B, and C. The influenza viruses A and B are considered seasonal flu that causes sniffling, aching, coughing, running and stuffy nose, and fever to over 20% of the general population.

Influenza virus type C tends to cause mild upper respiratory infections, similar to those of colds.

Healthy individuals who have influenza are usually recovered within one week.

However, people with the immature and weakened immune system such as young children under age 5, adults older than age 65 residents of nursing homes and other long-term care facilities, and chronic illnesses, such as asthma, heart disease, kidney disease, liver disease, and diabetes are not only associated with the risk of influenza but also increase the risk of influenza deadly complication.

Pregnant women and women up to two weeks postpartum due to changes in the immune system and other organs have been found to make a woman more prone to influenza and influenza complications.


Some researchers also suggested that obese people are also at a higher risk of the onset of influenza.

Dr. Green WD, the lead author at the University of North Carolina at Chapel Hill suggested that obese individuals associated with the impairment of the adaptive immune response at substantial risk of influenza.

The doctor team in the study " Obesity Impairs the Adaptive Immune Response to Influenza Virus" wrote, "Given the dramatic rise in obesity over the past few decades, this increased risk for influenza infection poses a serious public health threat because nearly 500 million adults and children worldwide are classified as obese".

"Obesity impairs the immune response to influenza and influenza vaccination through alterations of the cellular immune system. Compared with vaccinated healthy-weight adults, vaccinated obese adults have twice the risk of influenza or influenza-like illness despite equal serological response to vaccination".

The most common symptoms of influenza are high fever, runny nose, sore throat, muscle pains, headache, coughing, sneezing, and persistent fatigue.

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered healthy sweet food for replacing the use of white sugar and artificial sweetener.

In finding a natural ingredient and whole food for the prevention and treatment of influenza, researchers at a joint study led by Nagasaki University the antiviral activities of honey samples were evaluated using MDCK cells.

Application of Manuka honey efficiently inhibited influenza virus replication which is related to its virucidal effects.

Manuka honey at the dose of 3.13 mg/mL also improved the function of zanamivir or oseltamivir by reducing the maximum concentration of effectiveness to nearly 1/1000th for their single use.

Dr.Watanabe K, the lead scientist said, "Honey, in general, and particularly Manuka honey, has potent inhibitory activity against the influenza virus, demonstrating a potential medicinal value.


Moreover, by re-examining the anti-influenza effect of Luatang honey, researchers suspected that the efficacy may be associated with the presence of methylglyoxal (MGO), a key component of Manuka honey.

By evaluating the anti-influenza viral activity of MGO and its potential in combination treatments with neuraminidase (NA) inhibitors, researchers found that
* Injection of MGO inhibited influenza virus A/WSN/33 replication 50% inhibitory concentration = 240 ± 190 μM; 50% cytotoxic concentration = 1.4 ± 0.4 mM; selective index (SI) = 5.8, which is related to its virucidal effects.


* MGO exerted a promising activity against various influenza strains.


* MGO increases the effect of NA inhibitors by decreasing the to  ∼1/100(th) of their single usage.

* MGO also demonstrates a synergistic effect with NA inhibitor against the oseltamivir-resistant virus.

Taken together, Luatang honey processed bioactive compound methylglyoxal (MGO) may be considered a functional food for the prevention and combined with primary therapy for the treatment of influenza with no side effects, pending a larger and multi-center human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Anti-influenza viral effects of honey in vitro: potent high activity of manuka honey by Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N3.(PubMed)
(2) In vitro evaluation of synergistic inhibitory effects of neuraminidase inhibitors and methylglyoxal against influenza virus infection by Charyasriwong S1, Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N3. (PubMed)
(3) Obesity Impairs the Adaptive Immune Response to Influenza Virus by Green WD1, Beck MA. (PubMed).

#Omega3 Fatty Acids Exert their Anticancer Actions by Influencing Multiple Targets Implicated in Various Stages of Cancer Development

Kyle J. Norton

Cancer is a class of diseases in which a group of cells grow and multiply disorderly and uncontrollably in our body.
Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.


The digestive system including the gastrointestinal tract, the liver, pancreas, and gallbladder play a critical role to maintain the body's normal function by providing nutrients and fluids to the body and remove waste through the secretary system.

The gastrointestinal tract formed part of the digestive system is a series of hollow organs that form a long continuous passage from our mouth to our anus, including our mouth, esophagus, stomach, small intestine, large intestine, and anus.

Gastrointestinal cancer is a medical and chronic condition caused by the alternation of cell DNA in the gastrointestinal tract including the esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum, and anus.


The most common gastrointestinal cancer is gastric cancer, which is the fourth most commonly occurring cancer in men and the seventh most commonly occurring cancer in women.

According to worldwide statistics, over 1 million new cases were diagnosed in 2018 with the South Korean leading the map, second to Mongolia.

In other words, if you are Asian, you are at an increased risk of gastric cancer.
At the advanced stage, the cancer cell of the affected tissues can travel a distance away to infect the other tissues and organs, leading to secondary metastasis.

Epidemiologically, primary gastrointestinal cancer is more likely to spread to the stomach, esophageal cancer, breast cancer, renal cell carcinoma, and ovarian cancer.

The exact causes of gastrointestinal cancer are not identified. However, genetic preposition, unhealthy lifestyle, and medical conditions are some of the prevalent risks of the disease.

Some researchers suggested that a poor diet may have a strong implication on the incidence of gastrointestinal cancer.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of digestive diseases, researchers examined the effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs), particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on gastrointestinal (GI) cancer.

* n-3 PUFAs may exert their anticancer actions by influencing multiple targets implicated in various stages of cancer development.

* n-3 PUFAs especially imposed excellent actions of antiinflammation and antioxidation, as well as their restorative actions against gastrointestinal cancer developing by restoring or modifying the inflammation-associated lipid distortion and alteration of lipid rafts.

* However, the study of the effects of n-3 PUFAs against GI cancer is still limited.

Taken together, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention and treatment of GI cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Omega-3 polyunsaturated Fatty acids as a potential chemopreventive agent for gastrointestinal cancer by Park JM1, Kwon SH1, Han YM2, Hahm KB3, Kim EH. (PubMed)
(2) Potential applications of fish oils rich in omega-3 polyunsaturated fatty acids in the management of gastrointestinal cancer by Eltweri AM1, Thomas AL2, Metcalfe M3, Calder PC4, Dennison AR3, Bowrey DJ. (PubMed)