The Combination of N-Acetyl Cysteine, Alpha-Lipoic Acid, and #Bromelain Show a Significant Improvement in Endometiosis, Reserachers Say

Kyle J. Norton

Endometriosis is a medical condition caused by the tissue of the endometrium that grows outside the uterus, leading to severe abnormal pain.
Most cases of endometriosis are found to involve the ovaries, fallopian tubes, and the tissue lining the pelvis.

Some researchers suggested the cause of endometriosis is a result of a layer of endometriosis lining on the inside of the uterus being expelled, instead, some of the endometriosis tissues grow somewhere in the body in the last stage menstrual cycle (menstruation).

Endometriosis also reacts to hormone signals of the monthly menstrual cycle, by building up tissue, breaking it, and eliminating, according to the stage of the menstrual period. Since they grow in somewhere other than in the uterus when they break, the period blood has no way to exit, causing blood to attach to the organs or lining of the abdomen, resulting in scars or adhesion as well as weakening the normal function of organs.

According to statistics, endometriosis affects
a) About 20% of reproductive-age women with endometriosis present but without symptoms.

b) About 55% of women have developed the new onset of severe menstrual cramps.

c) About 25% of women with sub-fertility (less fertile than a normal couple)

Endometriosis can vary in appearance. It may be clear or white, reddish, brown or blue-black, and cysts. The condition can be classified according to the stage of severity:
* Minimal stage:
The top surface, is few in number. Commonly they are found in the inside wall of the uterus, ligaments, and ovary.

* Mild stage:
For deeper implants, greater numbers are presented. Commonly found in the same area as a minimal stage.

* Moderate stage:
In many implants, endometrial cysts are present, affecting ovary function, causing scar tissues and adhesion is also present.

* Severe stage:
Intensive peritoneal implants, large endometriomas present, and dense adhesion.
Each woman experiences differently from endometriosis. Some women may have extensive endometrial tissues in their bodies but feel little or no pain, while other women may only be in the early stage of endometriosis but have excessive pain.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a potential ingredient for the treatment of endometriosis-associated pelvic pain, researchers evaluated the antioxidant activity of a preparation containing N-acetyl cysteine, alpha lipoic acid, and bromelain.

The multicenter, open-label, non-comparative clinical trial included a sample of 398 patients with a mean age of 34.6 ± 7.2 years with endometriosis-associated pelvic pain.

According to the results of a combination of N-acetyl cysteine, alpha-lipoic acid, and bromelain treatment after 6 months, in comparison of 92.7% of the patients with pain intensity > 4 on the visual analog scale (VAS) at the baseline, the percentage was decreased to 87.2% (p = 0.074) at 3 months of treatment.

Also compared to the baseline, the percentage decreased even more at 82.7% (p < 0.05) at the 6 months of treatment.

More importantly, the use of medicine for pain relief also was also reduced upon the application of the combination, according to the results of the experiment.

Dr. Lete I, the lead scientist said in the final report, "Women with endometriosis who wish to become pregnant and are treated with a preparation containing N-acetyl cysteine, alpha lipoic acid, and bromelain experienced a significant improvement in endometriosis-associated pelvic pain and required lower intake of rescue analgesics".

Taken together, bromelain used alone or combined with other remedies may be considered supplements for the prevention and treatment of endometrial pain, pending the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(2) Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid, and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study by Lete I1, Mendoza N2, de la Viuda E3, Carmona F. (PubMed)

#Casticin Found in #ChasteTreeBerry Inhibits #Leukemia Through Cell Apoptosis and Cell Cycle Arrest, Researchers Say

Kyle J. Norton

Oral Administrated ripe fruit of Vitex agnus-castus (Vitex) may reduce the risk of various types of solid tumor cells, particularly leukemia.

Leukemia is a condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.

According to the Tokyo University of Pharmacy and Life Sciences, casticin,, the major chemical compound found in an extract from the ripe fruit of Vitex agnus-castus (Vitex) exhibited strong cytotoxic activities against on leukemia cell lines, HL-60 and U-937 in dose depending manner.


Additionally, the study also expressed an interesting result as the levels of cytotoxicity of Vitex/casticin were largely attributed to the degree of differentiation of leukemia cells depending to cancer cell line maturity, compared to the HL-60 cell line with less mature U-937 cell line.


Dr. Kikuchi H, the lead author said, "casticin accounted for approximately 1% weight of Vitex. Dose-dependent cytotoxicity of Vitex and casticin was observed in both cell lines, and HL-60 cells were more sensitive to the cytotoxicity of Vitex/casticin compared to U-937 cells".

In a further study, casticin, also displayed significant anti-leukemia activity cells through expression molecular mechanism. apoptosis and cell cycle arrest were observed through different assays.


The application of casticin yielded a result of cancer cell death at 75.3% at 12 in the G2 phase in tumor cells cycle division, increased and subsequently declined to 27% at 48 h which was an indication of leukemic cell death via apoptosis and mitotic catastrophe.


Other study in support to the above differentiation, suggested that the extract from the ripe fruit of Vitex angus-castus (Vitex), inhibited the leukemia cell lines probably due to other mechanism such as significant decrease levels of intracellular reactive oxygen species (ROS) and level of gp91(phox), an important component of NADPH oxidase, in production of oxidation, and mediated cytotoxicity in HL-60 cells by regulating ROS generation...

Taken together, Chaste tree berry has a significant implication in reduced risk and treatment of leukemia through a number of mechanisms, but intake of large amounts should be taken with care to prevent toxicity.


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Sources
(1) Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines by Kikuchi H1, Yuan B, Nishimura Y, Imai M, Furutani R, Kamoi S, Seno M, Fukushima S, Hazama S, Hirobe C, Ohyama K, Hu XM, Takagi N, Hirano T, Toyoda H.(PubMed)
(2) Casticin induces leukemic cell death through apoptosis and mitotic catastrophe by Shen JK1, Du HP, Yang M, Wang YG, Jin J.(PubMed)
(3) Involvement of histone H3 phosphorylation via the activation of p38 MAPK pathway and intracellular redox status in cytotoxicity of HL-60 cells induced by Vitex agnus-castus fruit extract by Kikuchi H1, Yuan B1, Yuhara E1, Imai M1, Furutani R1, Fukushima S1, Hazama S1, Hirobe C2, Ohyama K1, Takagi N3, Toyoda H1.(PubMed)

#Novel #Cranberry Extract #Oximacro(®) and its Ppurified A-Type Proanthocyanidins (PACs-A) Inhibit Herpes Simplex Virus 1 and 2 (HSV-1, 2) Infection, According to Studies

Kyle J. Norton

Herpes simplex virus 1 (HSV-1) primarily causes oral herpes, including cold sores and fever blisters around the mouth and on the face.

Herpes simplex virus-2 (HSV-2) primarily causes genital herpes and genital herpes outbreaks

Infection can be acute or chronic. In the acute phase of infection, after receiving the messages from the central nervous system related to the danger of microbial infection, the immune macrophages in the first line of defense stimulates the production of blood palette to the cover the wound and pro-inflammatory cytokines to the site of the infection to kill off pathogens which try to enter the body.

However, overproduction of pro-inflammatory cytokines in the acute phase of infection has also killed off or damage to the nearby healthy cells, leading to the formation of scars.

In most cases in a healthy individual, the immune system can easily eradicate all foreign invaders and the wound is recovered within days and weeks.

Symptoms of the acute infection include gastrointestinal discomforts, such as congestion vomiting or nausea, and diarrhea, short term joint or muscle pain, fever, headache, skin rash and cough, Some patients with acute infection also experience symptoms of swollen lymph nodes, an indication of the body is fighting infection.

In chronic infection, the symptoms are most vague or no specific symptoms, including bronchitis and asthma, persistent low-grade chronic joint and muscle pain, or swelling and the alternations between diarrhea and constipation, bloating, or heartburn, In other words, the symptoms are totally depended on the location of the low-grade inflammation.

Most cases of infection except those of viral infection are treated by topical antibiotic cream and/or oral antibiotics.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the treatment of skin infection, researchers investigated the effects of cranberry (Vaccinium macrocarpon Ait.) extracts Oximacro(®) against Herpes simplex type 1 (HSV-1) and type 2 (HSV-2) infections.

In vitro, the novel cranberry extract Oximacro(®) and its purified A-type proanthocyanidins (PACs-A) inhibited HSV-1 and HSV-2 replication.

Furthermore, Oximacro(®) prevented the adsorption of HSV-1 and HSV-2 to target cells.

Moreover, Oximacro(®) and its PACs-A targeted the viral envelope glycoproteins gD and gB to enter cells, thus resulting in the loss of infectivity of HSV particles.

Most importantly, Oximacro(®) completely exerted continuously its anti-HSV activity even at acidic pHs (3.0 and 4.0) and in the presence of 10% human serum proteins, and conditions that mimic the physiological properties of the vagina.

Based on the findings, researchers said, "Oximacro(®) as an attractive candidate for the development of novel microbicides of natural origin for the prevention of HSV infections".

Taken together, cranberry may be considered an immune-modulatory remedy, pending the confirmation of the larger sample size and multicenter human study.


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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibition of herpes simplex type 1 and type 2 infections by Oximacro(®), a cranberry extract with a high content of A-type proanthocyanidins (PACs-A) by Terlizzi ME1, Occhipinti A2, Luganini A3, Maffei ME4, Gribaudo G. (PubMed)

#Bromelain Inhibits the Levels of ADP and TRAP-6 Associated with Platelet Aggregation, According to Studies

Kyle J. Norton

Fibrinolysis is the condition associated with the enzymatic breakdown of fibrin in blood clots.
Where fibrin plays an essential role in hemostasis as the primary product of the coagulation cascade of fibrinolysis.

In other words, fibrinolysis is a process that prevents blood clots from growing to induce certain health problems such as cardiovascular disease.

Platelet aggregation is a condition characterized by platelets clumping together in the blood. The process also is necessary for the cover of vascular injury. However, overexpression of platelet counts in the blood is problematic for human health.

In other words, the production of blood platelets is to protect tissue injury against infection.
Furthermore, platelet disorders can lead to abnormal bleeding. Most common types of the genetic proposition of platelet disorders including

* Disorder of platelet adhesion, also known as Bernard-Soulier Syndrome is a condition in which the platelets fail to adhere together, leading to frequent bruises, nose bleeds, and bleeding in the mouth and gums.

* Disorder of platelet aggregation also known as Glanzmann Thrombasthenia is a condition that the platelets not only fail to cover at the site of an injury but also prolong the bleeding.

* Disorder of platelet secretion is a condition that causes the slowing down of normal platelet adhesion, aggregation, and repair of the blood vessel.

* Disorder of platelets procoagulant activity, also known as Scott Syndrome is a condition in which the platelets fail to promote activation of the blood clotting proteins.

Conventionally, certain medications with blood-thinning activity such as aspirin (ASA) and other drugs containing aspirin non-steroidal anti-inflammatory drugs, and some antibiotics may have a strong implication for the formation of platelets coagulation.

Dr. Wolberg AS in the examination of fibrinolysis in the changes in the local concentrations of pro- and anti-coagulants and cellular activities may affect the clot-forming wrote, "patterns of abnormal thrombin generation produce clots with altered fibrin structure and that these changes are associated with an increased risk of bleeding or thrombosis".

These results strongly outline the importance of fibrin in the formation of a blood clot in the presence of thrombin that converts fibrinogen to fibrin.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

In finding a potential compound for the treatment of fibrinolysis, researchers examined the influence of bromelain on platelet count, platelet aggregation, and platelet activity in vitro.

The study included blood samples taken from the antecubital vein of 10 healthy male non-smokers.

According to the tested observation, platelet count decreased after incubation with 2.5 and 5 mg bromelain/ml.

The levels of ADP and TRAP-6 associated with platelet aggregation were inhibited after incubation with 2.5 mg or 5 mg compared to control.

Interestingly, according to the flow cytometry, the percentage of the total number of platelets or unstimulated CD62P positive platelets.


In other words, under normal conditions, bromelain does not have any effect on unstimulated CD62P positive platelets even with higher incubation with 5 mg bromelain/ml compared to control.


However, after TRAP-6 stimulation with platelet aggregation, the incubation with 5 mg bromelain/ml led to a remarkable decrease, compared to the untreated control.

The changes of CD62P (TRAP-stimulated) and the results of platelet aggregation after incubation with bromelain in vitro may demonstrate the potential of bromelain as a substance for platelet inhibition.

Based on the findings, researchers said, "The changes of CD62P (TRAP-stimulated) and the results of platelet aggregation after incubation with bromelain in vitro may demonstrate the potential of bromelain as a substance for platelet inhibition".

These results suggested that bromelain has a strong effect on the prevention and treatment of cardiovascular disease associated with platelet aggregation.

Taken altogether, bromelain may be considered a remedy for the prevention and treatment of fibrinolysis,, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Properties and Therapeutic Application of Bromelain: A Review by Rajendra Pavan, Sapna Jain, Shraddha, and Ajay Kumar. (PMC)
(2) Thrombin generation and fibrin clot structure by Wolberg AS. (PubMed)

#Turmeric Inhibit Diabetic Neuropathy Through Its Antioxidant, Anti-inflammatory, and Antibacterial Activity in Vivos

Kyle J. Norton

Diabetic neuropathy is a complication of patients with diabetes associated with nerve damage, ranging from pain and numbness in your legs and feet to problems with your digestive system.
Most cases of diabetic neuropathy are involved in diabetics who have a history of hyperglycemia caused by long-term high levels of glucose in the bloodstream, urinary tract, blood vessels, and heart.

Diabetic neuropathy can be classified into 4 main types,.

* Peripheral neuropathy is the most common type of diabetic neuropathy, affecting the nerves that control the feet and legs first, followed by the hands and arms.

* The autonomic neuropathy that affects the nerves that control the heart, bladder, stomach, intestines, sex organs, and eyes.

* Radiculoplexus neuropathy found mostly in older patients affects nerves that control the thighs, hips, buttocks, or legs.

* Mononeuropathy or focal neuropathy also found commonly in older patients affects the nerves that control the face, middle of the body (torso), or leg.

The exact causes of diabetic neuropathy are totally depending on the type of neuropathy. However, damage to nerves and blood vessels in the affected area has been found to induce by over time, uncontrolled high blood sugar.

In other words, diabetic neuropathy is preventable by keeping the blood glucose in the healthy range.

Dr. Michael Greger M.D. FACLM in the article "the best diet for diabetic neuropathy" wrote, "
(By examing) people eating different diets found that nine months or more on a strict plant-based diet appeared to remove the trans fat from their bodies (or at least their butts). Their pain, however, didn’t take nine months to get better—it got better in days".

In the explanation of the results, the researcher continued, "More likely, it was due to an improvement in blood flow. “[N]erve biopsies in diabetics with severe progressive neuropathy…have shown small vessel disease within the nerve. There are blood vessels within our nerves that can get clogged up too. The oxygen levels in the nerves of diabetics were found to be lower than even the levels of oxygenated blood".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to find a potential ingredient for the treatment of diabetic neuropathy researchers examined turmeric's antioxidant properties, anti-inflammatory, CNS depressant effect, and antibacterial and antifungal properties.

According to the results of the experiment, turmeric has therapeutic effects in the reduction of the level of oxidative stress associated with the occurrence of the present complication.

Furthermore, turmeric also enhanced the anti-inflammatory and antibacterial activity against the spread of infection.

In other words, turmeric inhibited diabetic neuropathy through a number of mechanisms involved in antioxidant, anti-inflammatory, and antibacterial activity.

In order to review more information about the turmeric effect, researchers investigated Nishamalaki (NA), a combination of Curcuma longa and Emblica officinalis in the prevention of diabetic neuropathy.

The study included diabetic neuropathy in type 2 diabetic Wistar rats under treatment for 12 weeks.

Selected rats were randomly divided into group I (Control) vehicle-treated consisting of 6 rats and
group II-VII Diabetic Control, NA low dose, NA High dose, Glibenclamide, Pioglitazone, and Epalrestat respectively.

Diabetes-induced in 36 Wistar rats with Streptozotocin (STZ) (35mg/kg) intraperitoneally followed by High Fat High Fructose diet. After confirmation of the development of diabetes; rats were divided into six groups as the aforementioned division.

Compared to other treatment groups, Nishamalaki (NA) not only controlled hyperglycemia and reduced lipid levels but also effectively prevented the development of diabetic neuropathy.

Taken altogether, turmeric used alone or combined with other herbal medicine may be considered supplements for the prevention of diabetic neuropathy, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Investigation of the utility of Curcuma caesia in the treatment of diabetic neuropathy by Grover M1, Shah K2, Khullar G3, Gupta J1, Behl T. (PubMed)
(2) Evaluation of Effect of Nishamalaki on STZ and HFHF Diet-Induced Diabetic Neuropathy in Wistar Rats by Dawane JS1, Pandit VA2, Bhosale MS3, Khatavkar PS. (PubMed)(3) Best Diet for Diabetic Neuropathy. Written By Michael Greger M.D. FACLM on January 1st, 2019

#XiaoWeiYanPowder (XWYP) Decoction, Including #Dandelion Show a Therapeutic Effect on #IntestinalMetaplasia (IM) and #AtypicalHyperplasia (AH), According to Study

Kyle J. Norton

The stomach located between the esophagus and the small intestine is a muscular, hollow and important organ of the digestive tract.
The stomach plays a critical role in aiding the digestive system by secreting acid and enzymes that digest food induced by the stomach muscles that contract periodically, to churn the food and enhance digestion.

Atypical hyperplasia is a precancerous condition characterized by the accumulation of abnormal cells.

Intestinal metaplasia is a pre-gastric cancer condition caused by the change of cells in the stomach.

The exact causes of the condition are unknown. However, some researchers suggested that smoking and infection caused by H. pylori infection, genetic preposition, and environmental factors are some risk factors associated with the onset of intestinal metaplasia.

Gastric cancer is a medical condition characterized by irregular and uncontrollable cell growth in the stomach lining in the beginning. At the advanced stage, the malignant cells can travel a distance away through blood and fluid circulation to infect other healthy tissue and organs.

Researchers do not know why some people with the same health condition are susceptible to the risk of gastric cancer, while others do not. The exact causes of gastric cancer are also unknown. However, some researchers suggested that Age, diet, and stomach disease, such as can increase the risk of developing gastric cancer.

Both atrophic gastritis and gastric cancer share the common symptoms of stomach pain, nausea and vomiting, loss of appetite,... and indigestion. However, common symptoms of unexpected weight loss and stomach ulcers can only be found in gastric cancer while iron deficiency anemia is found in the majority of patients with atrophic gastritis.

According to the statistics provided by the American Cancer Society, in 2019, approximately, 27,510 cases of stomach cancer will be diagnosed (17,230 in men and 10,280 in women) and 11,140 people will die from gastric cancer (6,800 men and 4,340 women).

Overall, the 5-year survival rate for people with gastric cancer is 31%. Cancer diagnosed at the localized stage have a 5 years survival rate of 67%.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

In finding a natural ingredient for the prevention and treatment of gastric diseases, scientists examined the efficacy of Xiao Wei Yan Powder (XWYP) decoction on intestinal metaplasia (IM) and 104 cases of atypical hyperplasia (AH).

Where XWYP is a traditional Chinese Medicine formula containing Smilax glabrate, Hedyotis diffusae, Taraxacum mongolicum, Caesalpinia sappan, Paeonia alba, Cyperus rotundus, Bletilla striata, Glycyrrhiza uralensis, etc.

According to the results of 138 cases of intestinal metaplasia (IM) and 104 cases of atypical hyperplasia (AH) of the gastric mucosa of chronic gastritis that was treated by Xiao Wei Yan Powder (XWYP) orally 5-7g, for a period from 2-4 months, compared to control, the decoction showed a significant effect rate of IM was 91.3% and that of the AH was 92.16% compared to the control group of 21.3% and 14.46% respectively.

More precisely, XWYP not only had marked therapeutic effects for IM and AH but also showed no toxic effects in the animal experiments revealed no toxic effect,

These results strongly suggested that a safety guarantee was provided for its clinical application.

Taken altogether, Dandelion in combination with other Chinese medicines may be considered a remedy for the treatment of intestinal metaplasia and atypical hyperplasia (AH), pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Treatment of intestinal metaplasia and atypical hyperplasia of gastric mucosa with xiao wei yan powder].[Article in Chinese] by Liu XR1, Han WQ, Sun DR. (PubMed)

#Fastuosain Found in #Bromelain Exhibits Lung Cancer Ap[optosis by Blocking Cells Proliferation, Communication and Induced Inflammation, Researcher Say

Kyle J. Norton

Lung cancer is a chronic condition characterized by the irregular cell in the lung tissues caused by the alternation of cells' DNA.
The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream and exhaling carbon dioxide from the bloodstream.

According to the statistics, in the US, lung cancer is the leading cause of cancer deaths. In n 2007. lung caused the death of 158,683 Americans, including 88,329 men and 70,354 women i


There are several types of lung cancer including
1. Non-small cell lung cancer
Non-small cell lung cancer, the most common type of lung cancer grown and spread methodically and predictably, includes
* Squamous-cell carcinoma is often found in an outer area of the lung.

*Large-cell carcinoma found in the center of the lung by an air tube.

* Adenocarcinoma is found in any part of the lung.

2. Small cell lung cancer
Small cell lung cancer is an aggressive type of lung cancer. The cells of small cell cancer have been found to spread to distant parts of the body in a relatively early stage.
* Small cell carcinoma in which the cells are small, round, and resemble oats.

* Mixed small cell/large cell carcinoma, the malignant tumor is found in combining components of small cell lung carcinoma with large cell lung carcinoma.

* Combined small cell carcinoma, the malignant tumor is found by combining of a component of small cell lung carcinoma with components of non-small cell lung carcinoma


Out of many risk factors associated with the onset of lung cancer, some researchers suggested smokers are at substantial risk of the disease.

Dr. Ozlü T the lead scientist wrote, "It is estimated that deaths attributable to tobacco use will rise to 10 million by 2025, and one-third of all adult deaths are expected to be related to cigarette smoking".

And, "Tobacco use has been reported to be the main cause of 90% of male and 79% of female lung cancers. 90% of deaths from lung cancer are estimated to be due to smoking. The risk of lung cancer development is 20-40 times higher in lifelong smokers compared to non-smokers".

The results strongly suggested that if you are a smoker, your risk of lung cancer developing is rocketing.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural ingredient against lung cancer, researchers examined the effects of the antitumor effect of fastuosain, a cysteine proteinase from Bromelia fastuosa on the intravenous model of lung colonization in C57Bl/6 mice.

According to the tested assays, fastuosain showed reduced expression of the marker of cancer progression (CD44) and decreased invasion by inhibiting cancer cell communication and inflammation in tumor cells.

Furthermore, fastuosain also induced cancer apoptosis by blocking the function enzymes associated with cell proliferation.

Interestingly, in green fluorescent protein-chimeric animals, treatment with fastuosain did not change the number of cells that migrated to the lung, compared to PBS-injected control mice, but the number of positive major histocompatibility complex class II cells associated with antigens was increased significantly.

In other words, fastuosain anti-lung cancer activity is mainly involved in the direct effect of the enzyme and elicitation of protective antibodies.

Taken altogether, bromelain may be considered a supplement for the prevention and treatment of lung cancer, pending the confirmation of the larger sample size and multicenter human study.


Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antitumor effects in vitro and in vivo and mechanisms of protection against melanoma B16F10-Nex2 cells by fastuosain, a cysteine proteinase from Bromelia fastuosa by Guimarães-Ferreira CA1, Rodrigues EG, Mortara RA, Cabral H, Serrano FA, Ribeiro-dos-Santos R, Travassos LR. (PubMed)
(2) Melanoma heterogeneity: differential, invasive, metastatic properties and profiles of cathepsin B, D, and L activities in subclones of the B16F10-NEX2 cell line by Freitas ZF1, Rodrigues EG, Oliveira V, Carmona AK, Travassos LR. (PubMed)
(3) Smoking and lung cancer by Ozlü T1, Bülbül Y. (PubMed)