Kyle j. Norton
Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.
In other words, diabetes occurs when cells in the pancreas die off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Diabetic complications are any diseases associated with hyperglycemia if the blood glucose is not managed properly. Patients with diabetes may induce a number of complications including cardiovascular disease, neuropathy, nephropathy, retinopathy, and foot ulcer.
Cardiomyopathy is a disease associated with the heart muscle, leading to reduce functions of the heart to pump blood to the rest of the body.
Diabetic cardiomyopathy is a complication found in patients with diabetes associated with reducing the heart function in circulating blood through the body, leading to heart failure and increased accumulation of fluid in the lungs.
Diabetic cardiomyopathy is classified into different types, depending on the damage that has been affected, including
* Microangiopathy is a disorder that affects small blood vessels, leading to impaired myocardial blood flow reserve.
* Autonomic neuropathy is a disorder that affects the nerves that manage everyday body functions, leading to abnormal blood pressure, and heart rate.
* Endothelial dysfunction is a disorder associated with the damage of vascular endothelium. The condition is considered an early event of cardiovascular disease.
The most common causes of diabetic cardiomyopathy are myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia.
Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
With an aim to find a natural food for the prevention and treatment of diabetic complications, researchers examined the effect of sulforaphane (SFN) on T2DM-induced cardiac lipid accumulation and subsequent cardiomyopathy.
The study included male C57BL/6J mice fed a high-fat diet for 3months to induce insulin resistance, followed by treatment with 100mg/kg body-weight streptozotocin to induce hyperglycemia as the T2DM mouse model compared to age-matched mice fed a normal diet as control.
According to the tested analysis,
* SFN treatment significantly attenuated cardiac remodeling and dysfunction induced by T2DM.
* SFN treatment also significantly inhibited cardiac lipid accumulation, measured by Oil Red O staining, and improved cardiac inflammation oxidative stress and fibrosis, shown by down-regulating diabetes-induced PAI-1, TNF-α, CTGF, TGF-β, 3-NT, and 4-HNE expression involved in oxidation.
* SFN upregulated the expression of the gene associated with the promotion of antioxidant enzymes and decreased the expression in enhancing the initiation of oxidative stress.
* SFN also reversed diabetes-induced inhibition of LKB1/AMPK and its downstream targets associated with the regulation of lipid, cholesterol and glucose metabolism.
Based on the results, researchers wrote, " SFN treatment to T2DM mice may attenuate the cardiac oxidative stress-induced inhibition of LKB1/AMPK signaling pathway, thereby preventing T2DM-induced lipotoxicity and cardiomyopathy".
Taken altogether, broccoli processed abundantly SFN may be considered supplements for the prevention of diabetic cardiomyopathy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway by Zhang Z1, Wang S1, Zhou S1, Yan X2, Wang Y1, Chen J3, Mellen N3, Kong M4, Gu J5, Tan Y2, Zheng Y6, Cai L. (PubMed)
Thursday, 20 July 2023
#Coffee Intake Daily and Regularly Is Associated with A Reduced Risk of Stroke, Researchers Say
Kyle J. Norton
Coffee, second to green tea is a popular and social beverage all over the world, particularly in the West, made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.
A stroke is a medical condition characterized by interrupted blood supply, thus reducing oxygen and nutrient delivery to the brain, resulting in the death of brain cells.
Intake of coffee and coffee caffeine may have a profound effect in reducing the risk of stroke incidence, a renowned institute study suggested.
In a third National Health and Nutrition Examination Survey (1988-1994; NHANES III) data to examine coffee consumption and stroke with participants aged ≥17 years old, researchers found that
coffee intake of this population showed a significant inverse association to stroke risk incidence, regardless of smoking status.
Interestingly, the study also discovered that frequent coffee drinkers displayed a less occurrence of heart failure, diabetes, and hypertension but the risk of high cholesterol for those consuming ≥3 cups per day.
Dr. Liebeskind DS, the lead author said, "Heavier daily coffee consumption is associated with decreased stroke prevalence" and ". Multivariate analyses revealed an independent effect of heavier coffee consumption (≥3 cups/day) on reduced stroke".
Furthermore, in an analyzed data from a prospective cohort of 83,076 women in the Nurses' Health Study without a history of stroke, coronary heart disease, diabetes, or cancer at baseline, with coffee consumption assessed first in 1980, then repeatedly every 2 to 4 years, and follow-up through 2004, researchers at the Harvard School of Public Health filed the following results
1. The relative risk ratio of stroke in participants coffee consumption (<1 cup per month, 1 per month to 4 per week, 5 to 7 per week, 2 to 3 per day, and >or=4 per day) were 1, 0.98, 0.88, 0.81, and 0.80 repetitively.
2. Intake of coffee and coffee caffeine daily and regularly showed a significantly positive effect in reduced stroke risk after taking to count of other favors, including high blood pressure, hypercholesterolemia, and type 2 diabetes.
3. Risk of stroke is also associated stronger correlation among never and past smokers (RR for >or=4 cups a day versus <1 cup a month, 0.57) than among current smokers (RR for >or=4 cups a day versus <1 cup a month, 0.97).
4. Decaffeinated coffee intake also was associated with a trend in a lower risk of stroke after adjustment for caffeinated coffee consumption.
5. Caffeine consumption of other beverage do not associate to risk or reduced risk of stroke.
The findings suggested that long-term coffee consumption was not associated with the risk of stroke but modestly reduce the risk of stroke.
Promisingly, an Asian study of data obtained from the Health Examinees (HEXA) study, involving 146,830 individuals aged 40-69 years demonstrated that high coffee consumption was associated with a 38% lower odds ratio for stroke in women compared to (none drinkers vs. ≥ 3 cups/day drinkers in women but not in men.
The expression of coffee intake in reduced risk of stroke was also found greater in women who are healthy, younger, non-obese, non-hypertensive, non-diabetic, non-smokers, and non-alcohol drinkers.
Taking together, there is no doubt that the intake of coffee daily and regularly has a remarkable effect on the reduced risk of stroke, particularly in women.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) The coffee paradox in stroke: Increased consumption linked with fewer strokes by Liebeskind DS1, Sanossian N2, Fu KA2, Wang HJ3, Arab L4(PubMed)
(2) Coffee consumption and risk of stroke in women by Lopez-Garcia E1, Rodriguez-Artalejo F, Rexrode KM, Logroscino G, Hu FB, van Dam RM. (PubMed)
Coffee, second to green tea is a popular and social beverage all over the world, particularly in the West, made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.
A stroke is a medical condition characterized by interrupted blood supply, thus reducing oxygen and nutrient delivery to the brain, resulting in the death of brain cells.
Intake of coffee and coffee caffeine may have a profound effect in reducing the risk of stroke incidence, a renowned institute study suggested.
In a third National Health and Nutrition Examination Survey (1988-1994; NHANES III) data to examine coffee consumption and stroke with participants aged ≥17 years old, researchers found that
coffee intake of this population showed a significant inverse association to stroke risk incidence, regardless of smoking status.
Interestingly, the study also discovered that frequent coffee drinkers displayed a less occurrence of heart failure, diabetes, and hypertension but the risk of high cholesterol for those consuming ≥3 cups per day.
Dr. Liebeskind DS, the lead author said, "Heavier daily coffee consumption is associated with decreased stroke prevalence" and ". Multivariate analyses revealed an independent effect of heavier coffee consumption (≥3 cups/day) on reduced stroke".
Furthermore, in an analyzed data from a prospective cohort of 83,076 women in the Nurses' Health Study without a history of stroke, coronary heart disease, diabetes, or cancer at baseline, with coffee consumption assessed first in 1980, then repeatedly every 2 to 4 years, and follow-up through 2004, researchers at the Harvard School of Public Health filed the following results
1. The relative risk ratio of stroke in participants coffee consumption (<1 cup per month, 1 per month to 4 per week, 5 to 7 per week, 2 to 3 per day, and >or=4 per day) were 1, 0.98, 0.88, 0.81, and 0.80 repetitively.
2. Intake of coffee and coffee caffeine daily and regularly showed a significantly positive effect in reduced stroke risk after taking to count of other favors, including high blood pressure, hypercholesterolemia, and type 2 diabetes.
3. Risk of stroke is also associated stronger correlation among never and past smokers (RR for >or=4 cups a day versus <1 cup a month, 0.57) than among current smokers (RR for >or=4 cups a day versus <1 cup a month, 0.97).
4. Decaffeinated coffee intake also was associated with a trend in a lower risk of stroke after adjustment for caffeinated coffee consumption.
5. Caffeine consumption of other beverage do not associate to risk or reduced risk of stroke.
The findings suggested that long-term coffee consumption was not associated with the risk of stroke but modestly reduce the risk of stroke.
Promisingly, an Asian study of data obtained from the Health Examinees (HEXA) study, involving 146,830 individuals aged 40-69 years demonstrated that high coffee consumption was associated with a 38% lower odds ratio for stroke in women compared to (none drinkers vs. ≥ 3 cups/day drinkers in women but not in men.
The expression of coffee intake in reduced risk of stroke was also found greater in women who are healthy, younger, non-obese, non-hypertensive, non-diabetic, non-smokers, and non-alcohol drinkers.
Taking together, there is no doubt that the intake of coffee daily and regularly has a remarkable effect on the reduced risk of stroke, particularly in women.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) The coffee paradox in stroke: Increased consumption linked with fewer strokes by Liebeskind DS1, Sanossian N2, Fu KA2, Wang HJ3, Arab L4(PubMed)
(2) Coffee consumption and risk of stroke in women by Lopez-Garcia E1, Rodriguez-Artalejo F, Rexrode KM, Logroscino G, Hu FB, van Dam RM. (PubMed)
#Ginger and #Zingerone (ZGR) Show a Strong Effect Against Sepsis Through Its Anti-Inflammatory Activities, Scientists Show
Kyle J. Norton
Sepsis is a medical condition caused by the body's over-response to infection by releasing a large number of chemicals into the bloodstream, leading to a chemical imbalance that can damage multiple organ systems.
The most common sites of infection leading to sepsis are found in older patients with the lungs, urinary tract, tummy (abdomen), and pelvis.
The causes of sepsis, in most cases, are involved in people with a weakened immune system or a severe infection that allows the inflammation to spread to the entire body.
Sepsis can be life-threatening due to the interruption of blood flow to the body caused by inflammation in the induction of blood vessel constriction.
The risk factors of sepsis include any medical conditions which can lead to a weakened immune system, such as AIDs and chemotherapy, the very young (immature immune system) and old (weakened immune system due to aging), pregnancy, and diabetes.
The most common symptoms of sepsis are associated with symptoms of reduced blood flow, including, a decrease in mental ability, and problems breathing. abnormal heart functions, fall in blood pressure, and fall in body temperature. unconsciousness.
If your child or yourself experiences some of the above symptoms, please call the emergency services right away.
Some researchers suggested that people who are obese may have a negative implication on the immune system in fighting against infection that can cause sepsis.
Dr. A S Kolyva, the lead scientist said, "Sepsis is one of the most important causes of mortality in the developed world, where almost two-thirds of the population suffer from obesity".
And, "Obesity is associated with elevated TNFα adipose tissue production and increased oxidative stress biomarkers, promoting the proinflammatory response in septic patients".
These results strongly suggested that obesity may induce overexpression of proinflammatory cytokines that not only initiate the onset of sepsis and also increases the potential negative impact on the outcome.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural compound or food for the treatment of sepsis, researchers investigated the effects of a phenolic alkenone isolated from ginger in various pharmacological activities, including sepsis.
Injection of ginger exerted a modulatory effect on HMGB1-mediated septic responses and survival rate in a mouse model of sepsis.
The modulation of ginger was attributed to the suppression of the production of inflammatory cytokines such as TNF-α and IL-6 and the activation of proteins associated with inflammation induced by HMGB.
High mobility group box 1 (HMGB1) is a protein associated with the immune protective response by restoring the endothelial cells which line the interior surface of blood vessels and lymphatic vessel integrity.
Furthermore, the injection of ginger also inhibited HMGB1-mediated hyperpermeability and leukocyte migration in the initiation of inflammation in mice.
Moreover, in vivo, ginger inhibited the lymphopoiesis (CLP) in stimulating the production of the release of HMGB1, sepsis-related mortality, and tissue injury.
In order to reveal more information about ginger antisepsis activity, researchers examined zingerone (ZGR), a bioactive compound isolated from ginger on TGFBIp-mediated septic responses.
Similar to that of the above, ZGR reduced the TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice.
Injection of ZGR suppressed TGFBIp-induced sepsis lethality and pulmonary injury.
Dr. Min G, the lead scientist, after taking into account co and confounders wrote in the final report, "ZGR could be a potential therapeutic agent for the treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway".
Taken altogether, ginger may be considered a functional remedy for the treatment of sepsis, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Zingerone reduces HMGB1-mediated septic responses and improves survival in septic mice by Lee W1, Ku SK2, Bae JS. (PubMed)
(2) Suppressive effects of zingerone on TGFBIp-mediated septic responses by Min G1, Ku SK2, Lee T3, Bae JS4. (PubMed)
(3) The role of obesity in the immune response during sepsis by A S Kolyva,1 V Zolota,2 D Mpatsoulis,2 G Skroubis,3 E E Solomou,4 I G Habeos,5S F Assimakopoulos,1 N Goutzourelas,6 D Kouretas,6 and C A Gogos. (PMC).
Sepsis is a medical condition caused by the body's over-response to infection by releasing a large number of chemicals into the bloodstream, leading to a chemical imbalance that can damage multiple organ systems.
The most common sites of infection leading to sepsis are found in older patients with the lungs, urinary tract, tummy (abdomen), and pelvis.
The causes of sepsis, in most cases, are involved in people with a weakened immune system or a severe infection that allows the inflammation to spread to the entire body.
Sepsis can be life-threatening due to the interruption of blood flow to the body caused by inflammation in the induction of blood vessel constriction.
The risk factors of sepsis include any medical conditions which can lead to a weakened immune system, such as AIDs and chemotherapy, the very young (immature immune system) and old (weakened immune system due to aging), pregnancy, and diabetes.
The most common symptoms of sepsis are associated with symptoms of reduced blood flow, including, a decrease in mental ability, and problems breathing. abnormal heart functions, fall in blood pressure, and fall in body temperature. unconsciousness.
If your child or yourself experiences some of the above symptoms, please call the emergency services right away.
Some researchers suggested that people who are obese may have a negative implication on the immune system in fighting against infection that can cause sepsis.
Dr. A S Kolyva, the lead scientist said, "Sepsis is one of the most important causes of mortality in the developed world, where almost two-thirds of the population suffer from obesity".
And, "Obesity is associated with elevated TNFα adipose tissue production and increased oxidative stress biomarkers, promoting the proinflammatory response in septic patients".
These results strongly suggested that obesity may induce overexpression of proinflammatory cytokines that not only initiate the onset of sepsis and also increases the potential negative impact on the outcome.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural compound or food for the treatment of sepsis, researchers investigated the effects of a phenolic alkenone isolated from ginger in various pharmacological activities, including sepsis.
Injection of ginger exerted a modulatory effect on HMGB1-mediated septic responses and survival rate in a mouse model of sepsis.
The modulation of ginger was attributed to the suppression of the production of inflammatory cytokines such as TNF-α and IL-6 and the activation of proteins associated with inflammation induced by HMGB.
High mobility group box 1 (HMGB1) is a protein associated with the immune protective response by restoring the endothelial cells which line the interior surface of blood vessels and lymphatic vessel integrity.
Furthermore, the injection of ginger also inhibited HMGB1-mediated hyperpermeability and leukocyte migration in the initiation of inflammation in mice.
Moreover, in vivo, ginger inhibited the lymphopoiesis (CLP) in stimulating the production of the release of HMGB1, sepsis-related mortality, and tissue injury.
In order to reveal more information about ginger antisepsis activity, researchers examined zingerone (ZGR), a bioactive compound isolated from ginger on TGFBIp-mediated septic responses.
Similar to that of the above, ZGR reduced the TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice.
Injection of ZGR suppressed TGFBIp-induced sepsis lethality and pulmonary injury.
Dr. Min G, the lead scientist, after taking into account co and confounders wrote in the final report, "ZGR could be a potential therapeutic agent for the treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway".
Taken altogether, ginger may be considered a functional remedy for the treatment of sepsis, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Zingerone reduces HMGB1-mediated septic responses and improves survival in septic mice by Lee W1, Ku SK2, Bae JS. (PubMed)
(2) Suppressive effects of zingerone on TGFBIp-mediated septic responses by Min G1, Ku SK2, Lee T3, Bae JS4. (PubMed)
(3) The role of obesity in the immune response during sepsis by A S Kolyva,1 V Zolota,2 D Mpatsoulis,2 G Skroubis,3 E E Solomou,4 I G Habeos,5S F Assimakopoulos,1 N Goutzourelas,6 D Kouretas,6 and C A Gogos. (PMC).
#Alliin Protects The Heart Muscle Against Heart Attacks Through Its Anti-Inflammatory Activity, Reserachers Suggest
Kyle J. Norton
Myocardial infarction (MI) is a medical condition known as a heart attack caused by the blood flow decreasing or stopping to a part of the heart, leading to damage to the heart muscle.
In other words, myocardial infarction (MI) occurs due to the imbalance in oxygen supply and demand caused by plaque rupture with thrombus formation in an artery, leading to reduced blood flow to the heart.
According to the statistics provided by the CDC, every year, approximately, about 790,000 Americans have a heart attack, including 580,000 cases of a first heart attack and 210,000 people who have already had a first heart attack.
The most common symptoms of MI are pressure, tightness, pain, or a squeezing or aching sensation in your chest, digestive discomforts such as nausea, indigestion, heartburn, abdominal pain, shortness of breath, and dizziness.
Conventionally, treatment of myocardial infarction is focused to reduce the damage of the heart muscle accomplished through medical or mechanical means.
Dr. James TN in the examination of the complex causes of fatal myocardial infarction wrote, "It is too often deduced that myocardial infarction is due to coronary occlusion and that subsequent death needs no other explanation. But the great majority of myocardial infarctions are not fatal, whether treated or untreated".
And, "There is, of course, some relation to the size of the infarct and the presence or absence of complicating conditions such as diabetes mellitus or hypertension".
In other words, Myocardial infarction can be fatal if the incidence occurs in patients with other medical conditions associated with the risk of cardiovascular diseases, such as metabolic syndrome and diabetes.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
On finding a natural compound for the treatment of myocardial infarction, researchers examined the antihyperlipidemic, antilipoperoxidative, and antioxidant effects of S-allyl cysteine sulphoxide (SACS) in myocardial infarcted rats.
The study included rats-induced myocardial infarction by subcutaneous injection of isoproterenol (ISO) (150 mg kg(-1)) at an interval of 24 h for 2 days.
Before treatment of SACS, ISO-treated rats showed a significant increase in the levels of serum iron, uric acid, and blood glucose, Na(+) and Ca(2+) associated with electrical abnormalities in the heart.
ISO-treated rats showed a significant decrease in the levels of plasma iron-binding capacity, an indication of inflammation, serum total protein, and albumin/globulin ratio similar to those of patients with abnormal heart rhythm, heart K(+), and heart glycogen involved in weak heart muscles.
In other words, ISO has caused significant damage to the heart functioning physically in myocardial infarction rats.
Furthermore, ISO also induced significant production of proinflammatory cytokines observed by the significant increase in red blood cells, hemoglobin, packed cell volume, white blood cells, neutrophils, platelet count, and fibrinogen level.
Additionally, the heart failure marker of glycoproteins in serum and the heart were increased in both levels/concentrations.
However, oral pretreatment with SACS (40 and 80 mg kg(-1)) daily for a period of 35 days reversed all the biochemical parameters studied in ISO-induced rats.
Collectively, SACS showed a protective effect against ISO-induced myocardial infarction in tested rats.
Taken altogether, alliin may be considered a supplement for the prevention and treatment of myocardial infarction with no side effects, responding to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Alliin, a Garlic (Allium sativum) Compound, Prevents LPS-Induced Inflammation in 3T3-L1 Adipocytes by Saray Quintero-Fabián,1,2 Daniel Ortuño-Sahagún,1 Manuel Vázquez-Carrera,3 and Rocío Ivette López-Roa. (Hindawi)
(2) Protective effect of S-allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol-induced myocardial infarction in male Wistar rats by Sangeetha T1, Quine SD. (PubMed)
(3) Complex causes of fatal myocardial infarction by James TN. (PubMed
Myocardial infarction (MI) is a medical condition known as a heart attack caused by the blood flow decreasing or stopping to a part of the heart, leading to damage to the heart muscle.
In other words, myocardial infarction (MI) occurs due to the imbalance in oxygen supply and demand caused by plaque rupture with thrombus formation in an artery, leading to reduced blood flow to the heart.
According to the statistics provided by the CDC, every year, approximately, about 790,000 Americans have a heart attack, including 580,000 cases of a first heart attack and 210,000 people who have already had a first heart attack.
The most common symptoms of MI are pressure, tightness, pain, or a squeezing or aching sensation in your chest, digestive discomforts such as nausea, indigestion, heartburn, abdominal pain, shortness of breath, and dizziness.
Conventionally, treatment of myocardial infarction is focused to reduce the damage of the heart muscle accomplished through medical or mechanical means.
Dr. James TN in the examination of the complex causes of fatal myocardial infarction wrote, "It is too often deduced that myocardial infarction is due to coronary occlusion and that subsequent death needs no other explanation. But the great majority of myocardial infarctions are not fatal, whether treated or untreated".
And, "There is, of course, some relation to the size of the infarct and the presence or absence of complicating conditions such as diabetes mellitus or hypertension".
In other words, Myocardial infarction can be fatal if the incidence occurs in patients with other medical conditions associated with the risk of cardiovascular diseases, such as metabolic syndrome and diabetes.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
On finding a natural compound for the treatment of myocardial infarction, researchers examined the antihyperlipidemic, antilipoperoxidative, and antioxidant effects of S-allyl cysteine sulphoxide (SACS) in myocardial infarcted rats.
The study included rats-induced myocardial infarction by subcutaneous injection of isoproterenol (ISO) (150 mg kg(-1)) at an interval of 24 h for 2 days.
Before treatment of SACS, ISO-treated rats showed a significant increase in the levels of serum iron, uric acid, and blood glucose, Na(+) and Ca(2+) associated with electrical abnormalities in the heart.
ISO-treated rats showed a significant decrease in the levels of plasma iron-binding capacity, an indication of inflammation, serum total protein, and albumin/globulin ratio similar to those of patients with abnormal heart rhythm, heart K(+), and heart glycogen involved in weak heart muscles.
In other words, ISO has caused significant damage to the heart functioning physically in myocardial infarction rats.
Furthermore, ISO also induced significant production of proinflammatory cytokines observed by the significant increase in red blood cells, hemoglobin, packed cell volume, white blood cells, neutrophils, platelet count, and fibrinogen level.
Additionally, the heart failure marker of glycoproteins in serum and the heart were increased in both levels/concentrations.
However, oral pretreatment with SACS (40 and 80 mg kg(-1)) daily for a period of 35 days reversed all the biochemical parameters studied in ISO-induced rats.
Collectively, SACS showed a protective effect against ISO-induced myocardial infarction in tested rats.
Taken altogether, alliin may be considered a supplement for the prevention and treatment of myocardial infarction with no side effects, responding to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Alliin, a Garlic (Allium sativum) Compound, Prevents LPS-Induced Inflammation in 3T3-L1 Adipocytes by Saray Quintero-Fabián,1,2 Daniel Ortuño-Sahagún,1 Manuel Vázquez-Carrera,3 and Rocío Ivette López-Roa. (Hindawi)
(2) Protective effect of S-allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol-induced myocardial infarction in male Wistar rats by Sangeetha T1, Quine SD. (PubMed)
(3) Complex causes of fatal myocardial infarction by James TN. (PubMed
#Alliin Exhibits cardio-vascular Effects Against the Onset of #Atherosclerosis, Researchers Say
Kyle J. Norton
Atherosclerosis is a medical condition induced by arterial narrowing due to the accumulation of plague that weakens the arterial wall.
Atherosclerosis is the most common cause of heart disease and stroke in the Western world, depending on the location of oxygenated rich blood flow blockage.
A plague is made up of fat, cholesterol, calcium, and other substances in the blood.
According to epidemiological studies, diseases associated with atherosclerosis include coronary heart disease (plaque in arteries in or leading to the heart), angina (chest pain from reduced blood flow to the heart muscle), carotid artery disease (plaque in neck arteries supplying blood to the brain), and peripheral artery disease (plaque in arteries of the extremities, especially the legs).
According to the statistics provided by the CDC, coronary heart disease (CHD) caused by atherosclerosis is the most common type of heart disease, that kills over 370,000 people annually.
Every year about 735,000 Americans have a heart attack. Of these, 525,000 are a first heart attack and 210,000 happen in people who have already had a heart attack
Although there are many risk factors that increase the risk of plaque accumulation, some researchers suggested people who follow a high-fat diet without injection of an adequate amount of fruits and vegetables are at a higher risk of atherosclerosis.
Dr. Zhao Y, the lead scientist in the team on cardiovascular disease at the Chinese PLA General Hospital wrote, "Coronary artery disease has a significant genetic predisposition, which mainly results from atherosclerosis".
And, "(Pig fed with high-fat diet) At 6 months, plaque lesions appeared in the abdominal aorta and iliac artery, while at 8 months, they appeared in the coronary artery. At 12 months, atherosclerotic lesions could be found in all major arteries, while lipid core, cholesterol precipitation, and calcium deposition appeared in the most serious sites".
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find potential treatment for atherosclerosis, a leading cause of cardiovascular disease, researchers evaluated the capacity of Allium ursinum (wild garlic) leaf lyophilisate (WGLL; alliin content: 0.261%) to mitigate cardiovascular damage in hypercholesterolemic rabbits.
Selected tested New Zealand rabbits included in the study were divided into three groups: (i) cholesterol-free rabbit chow (control); (ii) rabbit chow containing 2% cholesterol (hypercholesterolemic, HC); (iii) rabbit chow containing 2% cholesterol + 2% WGLL (hypercholesterolemic treated, HCT); for eight weeks.
According to the differentiation at the zero- and eight-week time points, WGLL treatment protects the cardio functioning by mediating the increase in fractional shortening, correct ventricular function; peak systolic velocity; tricuspid annular systolic velocity in live animals.
Furthermore, WGLL improved aortic and coronary flow.
In other words, WGLL exerted cardiovascular protective activity by promoting the function of ventricles in blood circulation via regulating blood pressure.
Moreover, the Western blot analysis revealed WGLL-associated increases in HO-1 protein associated with reduced cardio oxidative stress and decreases in SOD-1 protein involved oxygen metabolism.
Interestingly, WGLL also expressed a significant decrease in aortic atherosclerotic plaque coverage, plasma ApoB, an important component of many lipoproteins involved in atherosclerosis and cardiovascular disease. and the activity of LDH and CK (creatine kinase) in plasma.
Particularly, the chemical compound also inhibited the plasma LDL.
Based on the findings, researchers wrote in the final report, "The results clearly demonstrate that WGLL has complex cardioprotective effects, suggesting future strategies for its use in prevention and therapy for atherosclerotic disorders".
Taken altogether, alliin may be considered supplements for the prevention and treatment of atherosclerosis, pending the confirmation of the larger sample size and multicenter human study.
Intake of alliin as a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits by Bombicz M1,2, Priksz D3,4, Varga B5,6, Gesztelyi R7, Kertesz A8, Lengyel P9, Balogh P10, Csupor D11, Hohmann J12, Bhattoa HP13, Haines DD14, Juhasz B. (PubMed)
(2) Atherosclerosis Induced by a High-Cholesterol and High-Fat Diet in the Inbred Strain of the Wuzhishan Miniature Pig by Zhao Y1, Xiang L1, Liu Y1, Niu M1, Yuan J1, Chen H. (PubMed)
Atherosclerosis is a medical condition induced by arterial narrowing due to the accumulation of plague that weakens the arterial wall.
Atherosclerosis is the most common cause of heart disease and stroke in the Western world, depending on the location of oxygenated rich blood flow blockage.
A plague is made up of fat, cholesterol, calcium, and other substances in the blood.
According to epidemiological studies, diseases associated with atherosclerosis include coronary heart disease (plaque in arteries in or leading to the heart), angina (chest pain from reduced blood flow to the heart muscle), carotid artery disease (plaque in neck arteries supplying blood to the brain), and peripheral artery disease (plaque in arteries of the extremities, especially the legs).
According to the statistics provided by the CDC, coronary heart disease (CHD) caused by atherosclerosis is the most common type of heart disease, that kills over 370,000 people annually.
Every year about 735,000 Americans have a heart attack. Of these, 525,000 are a first heart attack and 210,000 happen in people who have already had a heart attack
Although there are many risk factors that increase the risk of plaque accumulation, some researchers suggested people who follow a high-fat diet without injection of an adequate amount of fruits and vegetables are at a higher risk of atherosclerosis.
Dr. Zhao Y, the lead scientist in the team on cardiovascular disease at the Chinese PLA General Hospital wrote, "Coronary artery disease has a significant genetic predisposition, which mainly results from atherosclerosis".
And, "(Pig fed with high-fat diet) At 6 months, plaque lesions appeared in the abdominal aorta and iliac artery, while at 8 months, they appeared in the coronary artery. At 12 months, atherosclerotic lesions could be found in all major arteries, while lipid core, cholesterol precipitation, and calcium deposition appeared in the most serious sites".
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find potential treatment for atherosclerosis, a leading cause of cardiovascular disease, researchers evaluated the capacity of Allium ursinum (wild garlic) leaf lyophilisate (WGLL; alliin content: 0.261%) to mitigate cardiovascular damage in hypercholesterolemic rabbits.
Selected tested New Zealand rabbits included in the study were divided into three groups: (i) cholesterol-free rabbit chow (control); (ii) rabbit chow containing 2% cholesterol (hypercholesterolemic, HC); (iii) rabbit chow containing 2% cholesterol + 2% WGLL (hypercholesterolemic treated, HCT); for eight weeks.
According to the differentiation at the zero- and eight-week time points, WGLL treatment protects the cardio functioning by mediating the increase in fractional shortening, correct ventricular function; peak systolic velocity; tricuspid annular systolic velocity in live animals.
Furthermore, WGLL improved aortic and coronary flow.
In other words, WGLL exerted cardiovascular protective activity by promoting the function of ventricles in blood circulation via regulating blood pressure.
Moreover, the Western blot analysis revealed WGLL-associated increases in HO-1 protein associated with reduced cardio oxidative stress and decreases in SOD-1 protein involved oxygen metabolism.
Interestingly, WGLL also expressed a significant decrease in aortic atherosclerotic plaque coverage, plasma ApoB, an important component of many lipoproteins involved in atherosclerosis and cardiovascular disease. and the activity of LDH and CK (creatine kinase) in plasma.
Particularly, the chemical compound also inhibited the plasma LDL.
Based on the findings, researchers wrote in the final report, "The results clearly demonstrate that WGLL has complex cardioprotective effects, suggesting future strategies for its use in prevention and therapy for atherosclerotic disorders".
Taken altogether, alliin may be considered supplements for the prevention and treatment of atherosclerosis, pending the confirmation of the larger sample size and multicenter human study.
Intake of alliin as a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits by Bombicz M1,2, Priksz D3,4, Varga B5,6, Gesztelyi R7, Kertesz A8, Lengyel P9, Balogh P10, Csupor D11, Hohmann J12, Bhattoa HP13, Haines DD14, Juhasz B. (PubMed)
(2) Atherosclerosis Induced by a High-Cholesterol and High-Fat Diet in the Inbred Strain of the Wuzhishan Miniature Pig by Zhao Y1, Xiang L1, Liu Y1, Niu M1, Yuan J1, Chen H. (PubMed)
#RedBeetroot, the FDA-Approved Red Food Color E162 and Its Extract Inhibits Breast Cancer Cells Through Its Cytotoxicity
Kyle J. Norton
The breasts of women are made of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of a woman's breast is totally depending on the amount of fat in the breast. Breast cancer is a medical condition caused by cell growth irregularly due to the alternation of cell DNA.
Most cases of breast cancer start in the cells on the surface of the inner lining of the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk, before colonizing the deeper layer tissues to form a tumor through proliferation.
According to the statistics, in the US, the lifetime risk of getting invasive breast cancer of a woman is 1/8. In 2019, approximately 268,600 new cases of invasive breast cancer will be diagnosed, along with 62,930 new cases of non-invasive (in situ) breast cancer.
The 5 years survival rate of breast cancer diagnosed in the localized stage is 100%.
The exact causes of breast cancer are not identified.
The stages of breast cancer can be classified depending on
* The size of the cancer
* Invasive or not
* Whether cancer has spread to the lymph nodes
* Whether cancer has spread to distant parts or organs of the body.
There are 4 stages of breast cancer in TNM rating (where T is referred for tumor size, N is referred for Lymph Node status, and M is referred for invasive or not)
# T: Tumor Size is divided into four classes: T-1 is between 0 - 2 cms, T-2 is between 2 - 5 cms, T-3 is > 5cms, and T-4 is a tumor of any size growing into the chest wall or skin, including inflammatory breast cancer.
#N: No swollen nodes: N-0, some swelling but negative node (not cancerous): N-1a, swelling nodes and positive node (cancerous): N-1b, quite swollen and bunched together: N-2, quite swollen and near the collarbone: N-3.
# M: if no cancer cell is found: M-0, cancer cells found: M-1.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belongings to the group of Betalains, found abundantly in beets, chard, etc.
In finding a potential compound for the treatment of breast cancer, researchers examined the effect of an extract of red beetroot (Beta vulgaris L.), the FDA-approved red food color E162 on estrogen receptor-positive human breast cancer cells (MCF-7).
According to the tested differentiation, both doxorubicin and the beetroot extract exhibited a dose-dependent cytotoxic effect in MCF-7.
Compared to doxorubicin, the cytotoxicity of beetroot extract was significantly lower.
In other words, at the same doses, doxorubicin is more effective to induce the death of breast cancer cells compared to the beetroot extract.
Due to the limitation of the experimental selection, side effects induced by both treatments cannot be observed.
After taking other factors into account, researchers suggested, the principal betacyanin constituent may play an important role in the cytotoxicity exhibited by the red beetroot extract.
Taken altogether, betacyanins may be considered a remedy for preventing and treating breast cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer-cell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)
(2) Breast #Cancer by Kyle J. Norton
The breasts of women are made of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of a woman's breast is totally depending on the amount of fat in the breast. Breast cancer is a medical condition caused by cell growth irregularly due to the alternation of cell DNA.
Most cases of breast cancer start in the cells on the surface of the inner lining of the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk, before colonizing the deeper layer tissues to form a tumor through proliferation.
According to the statistics, in the US, the lifetime risk of getting invasive breast cancer of a woman is 1/8. In 2019, approximately 268,600 new cases of invasive breast cancer will be diagnosed, along with 62,930 new cases of non-invasive (in situ) breast cancer.
The 5 years survival rate of breast cancer diagnosed in the localized stage is 100%.
The exact causes of breast cancer are not identified.
The stages of breast cancer can be classified depending on
* The size of the cancer
* Invasive or not
* Whether cancer has spread to the lymph nodes
* Whether cancer has spread to distant parts or organs of the body.
There are 4 stages of breast cancer in TNM rating (where T is referred for tumor size, N is referred for Lymph Node status, and M is referred for invasive or not)
# T: Tumor Size is divided into four classes: T-1 is between 0 - 2 cms, T-2 is between 2 - 5 cms, T-3 is > 5cms, and T-4 is a tumor of any size growing into the chest wall or skin, including inflammatory breast cancer.
#N: No swollen nodes: N-0, some swelling but negative node (not cancerous): N-1a, swelling nodes and positive node (cancerous): N-1b, quite swollen and bunched together: N-2, quite swollen and near the collarbone: N-3.
# M: if no cancer cell is found: M-0, cancer cells found: M-1.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belongings to the group of Betalains, found abundantly in beets, chard, etc.
In finding a potential compound for the treatment of breast cancer, researchers examined the effect of an extract of red beetroot (Beta vulgaris L.), the FDA-approved red food color E162 on estrogen receptor-positive human breast cancer cells (MCF-7).
According to the tested differentiation, both doxorubicin and the beetroot extract exhibited a dose-dependent cytotoxic effect in MCF-7.
Compared to doxorubicin, the cytotoxicity of beetroot extract was significantly lower.
In other words, at the same doses, doxorubicin is more effective to induce the death of breast cancer cells compared to the beetroot extract.
Due to the limitation of the experimental selection, side effects induced by both treatments cannot be observed.
After taking other factors into account, researchers suggested, the principal betacyanin constituent may play an important role in the cytotoxicity exhibited by the red beetroot extract.
Taken altogether, betacyanins may be considered a remedy for preventing and treating breast cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer-cell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)
(2) Breast #Cancer by Kyle J. Norton
#Antioxidant #Sinigrin and Free Radical #NitricOxide (NO) #Healthbenefits and #SideEffects, According to Researchers
Kyle J. Norton
Antioxidants are stable molecules that inhibit oxidation. Antioxidants are either produced by the host or from dietary sources.
Under normal conditions, antioxidants produced by the body are good enough to counter the presence of free radicals in the body of a healthy individual.
However, in people with a weakened immune system or medical condition, intake of dietary antioxidants may be necessary due to the depletion of the antioxidant enzymes.
Free radicals are unstable molecules with a single electron in the outer ring. Therefore for them to maintain stability, they must either donate or intercept an electron from other molecules, leading to a chain reaction that can not be stopped until they are either inhibited by antioxidants or electrons are paired.
Oxidative stress is an imbalance of the ratio of free radicals and antioxidants in the body caused by either overexpression of free radicals or depletion of antioxidant enzymes produced by the host.
Epidemiological studies suggested that oxidative stress has been found to cause lipid and protein and cellular damage, leading to the onset of chronic diseases, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.
Out of many risk factors associated with the onset of oxidative stress, widespread obesity may be one of the significant factors that contribute to the severity of the disease due to oxidative stress.
Dr. Keaney JF Jr said, "Smoking, diabetes, and body mass index were highly associated with systemic oxidative stress as determined by creatinine-indexed urinary 8-epi-PGF2alpha levels. The effect of body mass index was minimally affected by blood glucose, and diabetes and may suggest an important role of oxidative stress in the deleterious impact of obesity on cardiovascular disease".
Researchers to find a natural ingredient that processes a strong antioxidant activity for the treatment of diseases associated with oxidative stress investigated the antioxidant property of sinigrin.
Injection of sinigrin suppressed nitric oxide (NO) production, a free radical that is found to process many health benefits such as increased blood flow and blood vessel relaxation, reduced risk of CVD, and side effects such as induced oxidative stress causing neuro, kidney, and liver toxicity by reducing the levels of nitric oxide synthase.
In rat study. oral administration of the compound also showed reduced levels of urinary nitrate + nitrite and allyl isothiocyanate. In other words, sinigrin inhibited the production of free radical expression through its antioxidant activity.
In non-alcoholic fatty liver disease (NAFLD), sinigrin exerted antioxidative stress potency by inhibiting lipid peroxidation, mitochondrial dysfunction, and oxidative balance impairment (oxidative stress) in facilitating the progression of hepatic steatosis.
Mitochondrial dysfunction is found to interfere with cells' function in producing energy for cell or organ needs.
Oxidative balance impairment is another term for oxidative stress.
More precisely, it is caused by either overexpression of reactive oxygen species and/or depletion of antioxidant enzymes produced by the host.
Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of a large sample size and multicenter human study.
However, intake of bioactive in the form of supplements should be taken with extreme care, as liver toxicity may be induced if overdosed.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antioxidant dietary approach in the treatment of fatty liver: New insights and updates by Alessandra Ferramosca, Mariangela Di Giacomo, and Vincenzo Zara. (PMC)
(2) (1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi, and Jeanetta du Plessis. (PubMed)
(3) Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study by Keaney JF Jr1, Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, Massaro JM, Sutherland P, Vita JA, Benjamin EJ; Framingham Study. (PubMed)
Antioxidants are stable molecules that inhibit oxidation. Antioxidants are either produced by the host or from dietary sources.
Under normal conditions, antioxidants produced by the body are good enough to counter the presence of free radicals in the body of a healthy individual.
However, in people with a weakened immune system or medical condition, intake of dietary antioxidants may be necessary due to the depletion of the antioxidant enzymes.
Free radicals are unstable molecules with a single electron in the outer ring. Therefore for them to maintain stability, they must either donate or intercept an electron from other molecules, leading to a chain reaction that can not be stopped until they are either inhibited by antioxidants or electrons are paired.
Oxidative stress is an imbalance of the ratio of free radicals and antioxidants in the body caused by either overexpression of free radicals or depletion of antioxidant enzymes produced by the host.
Epidemiological studies suggested that oxidative stress has been found to cause lipid and protein and cellular damage, leading to the onset of chronic diseases, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.
Out of many risk factors associated with the onset of oxidative stress, widespread obesity may be one of the significant factors that contribute to the severity of the disease due to oxidative stress.
Dr. Keaney JF Jr said, "Smoking, diabetes, and body mass index were highly associated with systemic oxidative stress as determined by creatinine-indexed urinary 8-epi-PGF2alpha levels. The effect of body mass index was minimally affected by blood glucose, and diabetes and may suggest an important role of oxidative stress in the deleterious impact of obesity on cardiovascular disease".
Researchers to find a natural ingredient that processes a strong antioxidant activity for the treatment of diseases associated with oxidative stress investigated the antioxidant property of sinigrin.
Injection of sinigrin suppressed nitric oxide (NO) production, a free radical that is found to process many health benefits such as increased blood flow and blood vessel relaxation, reduced risk of CVD, and side effects such as induced oxidative stress causing neuro, kidney, and liver toxicity by reducing the levels of nitric oxide synthase.
In rat study. oral administration of the compound also showed reduced levels of urinary nitrate + nitrite and allyl isothiocyanate. In other words, sinigrin inhibited the production of free radical expression through its antioxidant activity.
In non-alcoholic fatty liver disease (NAFLD), sinigrin exerted antioxidative stress potency by inhibiting lipid peroxidation, mitochondrial dysfunction, and oxidative balance impairment (oxidative stress) in facilitating the progression of hepatic steatosis.
Mitochondrial dysfunction is found to interfere with cells' function in producing energy for cell or organ needs.
Oxidative balance impairment is another term for oxidative stress.
More precisely, it is caused by either overexpression of reactive oxygen species and/or depletion of antioxidant enzymes produced by the host.
Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of a large sample size and multicenter human study.
However, intake of bioactive in the form of supplements should be taken with extreme care, as liver toxicity may be induced if overdosed.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antioxidant dietary approach in the treatment of fatty liver: New insights and updates by Alessandra Ferramosca, Mariangela Di Giacomo, and Vincenzo Zara. (PMC)
(2) (1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi, and Jeanetta du Plessis. (PubMed)
(3) Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study by Keaney JF Jr1, Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, Massaro JM, Sutherland P, Vita JA, Benjamin EJ; Framingham Study. (PubMed)
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