#Cranberry Extract #Supplementation Exerts Anti-# Alzheimer's disease Effects through Alleviating Aβ Toxicity, According to Studies

Kyle J. Norton

Dementia is a neuropsychiatric disorder as a result of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, contributing to caregiver burden and premature institutionalization.

About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age.

Dementia is the loss of mental ability that is severe enough to interfere with people's every life.

Alzheimer's disease (AD) is a neurodegenerative disease occurred mostly in the older population characterized by progressive brain cell death that happens over time.

Alzheimer's disease worsens over time and it is fatal.

American typical diet contains a high amount of saturated and trans fat, artificial ingredients with fewer fruits and vegetables which can lead to dementia and other kinds of diseases.

As the disease progresses, the brain tissue of the patient with AD has fewer and fewer nerve cells and connections.

In the elderly, age-related changes in the brain include atrophy (shrinking) of certain parts of the brain, inflammation associated with overexpression of free radicals in the induction of neuro cytotoxicity that affects the energy production within cells and long-term accumulation of plaques in the neurons caused by unhealthy diet are many prevalent risk factors that elevate the early onset and progression of the disease.

In free radical theory, free radical overexpression causes the reduced levels of antioxidant enzymes produced by the elderly to initiate the onset of oxidative stress that may attack and damage lipids, proteins, and DNA, leading to irreversible brain cell damage and the development of AD.

β-amyloid (Aβ) accumulated in the neurons, the main component of the amyloid plaques in the brains have been found in patients with Alzheimer's disease.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the treatment of dementia, researchers investigated the cranberry extract (CBE) rich in polyphenols that delay paralysis induced by alleviating β-amyloid (Aβ) toxicity in Alzheimer's disease (AD) in the C. elegans model.

According to the experimental results, researchers suggested that CBE showed a strong anti-AD activity by inhibiting the level of Aβ toxicity and promoting memory health, the two major pathological parameters in AD.

C. elegans AD model treated with CBE exerted significant preventive and therapeutic protocols.

Based on the findings, researchers said, "CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals".

Taken altogether, cranberry may be considered a remedy for the management of AD, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in the Caenorhabditis elegans model of Alzheimer's disease by Guo H1, Dong YQ2, Ye BP. (PubMed)

The Top 7 Wholefoods Which Inhibit the Risk of #BreastCancer, Scientists Find

Kyle J. Norton

The prevalence of breast cancer has been acknowledged in the scientific community worldwide.
Breast cancer is widespread in women in Southeast Asia as a result of over 2 decades of economic prosperity caused by unhealthy diet is a major concern.

The findings for effective treatments are ongoing with some successes, but discovering effective prevention and treatment with little or no side effects has proven difficult.

According to statistics, the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Suggestions of a healthy diet with plenty of vegetables and fruits(1)(2)(3) with a change of lifestyle (4)(5)(6) may be the only choice for women in reducing the risk of the diseases.

1. Black Rice
Black Rice is a type of rice with enriched Anthocyanins. including Indonesian black rice and Thai jasmine black rice, considered one of nature's superfoods with various antioxidants.

Anthocyanins in black rice, oral administration of AEBR (100 mg/kg/day) to BALB/c nude mice bearing MDA-MB-453 cell xenografts significantly suppressed tumor growth and angiogenesis by suppressing the expression of the physiological process factors MMP-9MMP-2(enzymes involved in the breakdown of extracellular matrix), and uPA(activator) in tumor tissue.

AEBR also induced human breast cancer cells by inducing apoptosis and suppressing angiogenesis(37)(38).

Other chemical constituents of species of black glumed’ Njavara (Oryza sativa L.) isolation, namely, flavonolignans, tricin 4'-O-(erythro-β-guaiacylglyceryl) ether (compound 1) and tricin 4'-O-(threo-β-guaiacylglyceryl) ether (compound 2), also inhibited breast cancer cell line MCF-7, by inducing apoptosis at concentration 40 and 30 μg/ and chromatin condensation by decreasing protein in the mitochondrial membrane(39).

2. Green tea
Green tea contains more amount of antioxidants than any drink or food with the same volume is the leaves of Camellia sinensis, which undergo minimal oxidation during processing, originated from China.

Regular green tea intake is associated with an inverse risk of breast cancer, as green tea enhanced the production of Ki-67, a cancer antigen compared to non-drinkers. (63).

(-)-epigallocatechin gallate, a phytochemical in green tea exert its epigenetic effects in altering the DNA methyltransferase expression in many types of cancer, including breast cancer(64).

Catechins, another phytochemical of green tea, inhibited the proliferation of breast cancer cells and blocked carcinogenesis in breast cancer probably through the expression of translocation across membranes or for degradation, ribonucleoprotein DNA reduplication, apoptotic cascade, etc.(65).

In inflammatory breast cancer, a most aggressive type of breast cancer, green tea polyphenol epigallocatechin-3-gallate (EGCG), decreased expression of genes in promoted proliferation, migration, invasion, and survival in human breast cancer cell lines, SUM-149 and SUM-190 by reduced lymphangiogenesis-promoting genes(66) and inhibited the cell proliferation at 72 hours, after 10 microM of EGCG treatment.

These suggested green tea induced a reactivation of apoptosis, probably through the complexity of the angiogenic switch which can lead to the modulation of the cell migration processes against triple-negative breast cancer cells (67).

In human breast cancer MCF-7 cells, selenium-containing polysaccharides (Se-GTPs) from a new variety of selenium-enriched Ziyang green tea, in dose-dependent, exhibited an effective cell growth inhibition by inducing MCF-7 cancer cells to undergo G2/M(cell cycle) phase arrest and apoptosis by up-regulation of p53 (tumor antigen) expression(68).

Unfortunately, epidemiological data, on the incidence of breast cancer and the recurrence of breast cancer, consumption of 5 or more cups of green tea a day showed a non-statistically significant trend towards the prevention of breast cancer development. But some evidence indicated that green tea consumption may possibly help prevent breast cancer recurrence in early-stage (I and II) cancers(69).

3. Red wine
Red wine, made from the pigments of grape varieties is a wine that involved the extraction of color, and flavor components from the grape skin.

Red wine phenolics piceatannol and myricetin reduced the proliferation of estrogen hormone-dependent breast cancer cells by binding to the gene expression of estrogen receptor (ER) alpha, which interacts with responsive DNA sequences located within the promoter region of target genes(70).

Catechin hydrate (CH), an antioxidant in red wine, induced apoptosis against MCF-7 cells, with a rate of 40.7% and 41.16% in the volume of 150 μg/ml CH in 24 hours, respectively.

Moreover, a 48-hour exposure to 150 μg/ml CH and 300 μg/ml CH resulted in 43.73% and 52.95% apoptotic cells, through increased expression of pro-apoptotic genes such as caspase-3, -8, and -9 and TP53(71).

4. Black bean
Black bean is a Small roughly ovoid legume with glossy black shells, genus Phaseolus, belongings to the family Fabaceae. It is believed that the black bean was the first domesticated growth in South America.

Water-soluble condensed tannins isolated from black beans inhibited breast cancer cell line MCF-7 at 24 microM by suppressing a fetal bovine serum (blood fraction remaining after the natural coagulation of blood) stimulated cell migration and the secretion of matrix metalloproteinase-2 (MMP-2 or gelatinase A), matrix metalloproteinase-9 (MMP-9 or gelatinase B)(involved in the breakdown of extracellular matrix), and vascular endothelial growth factor VEGF(165)(regulator of angiogenesis) receptors expression(72).

The phytochemical of black bean (Phaseolus vulgaris) seed coats, also enhanced potent antioxidant and anti-proliferative activities against MCF-7 human breast cancer cells in doses depending on manner(73).

5. Fermented soybean
Fermented soybean made from ground soybeans, is a popular ingredient used in the cuisines of East and Southeast Asia.

Chungkookjang, a Korean fermented soybean, containing a high concentration of isoflavones and peptides inhibited the growth of breast cancer MCF7 cells in decreased dependent on the concentration by activating the TGFβ pathway in cellular processes and depressing inflammation(74).

In murine breast adenocarcinoma, fermented soy products (FSP) are effective in tumor containment with the smallest tumor volumes. (75).

6. Peanut
Peanuts, belonging to the legume related to the bean family are first cultivated in the Chaco region of Paraguay and Bolivia.

Lectin ( (PNA), a chemical constituent of peanut was effective in inhibiting the proliferation of human breast cell lines (ZR-75.1 and 734-B)(76) and MCF-7, T 47D, HBL 100, BT 20(77).

Beta-Sitosterol found in legumes, oil seeds, and unrefined plant oils such as peanut butter, pistachios, and sunflower, exhibited the extrinsic apoptotic programmed cell death pathway in human breast MCF-7 and MDA-MB-231(78).

7. Faxseed
Flax seed also known as common flax or linseed is native to the region of the eastern Mediterranean to India.

A study of athymic mice fed with basal diet (control), or 10% FS diet, with or without TRAS (2.5mg/kg) for 5 wk, displayed positive effects in reduced tumor size and increased tumor apoptosis.

Dietary FS improved the function of TRAS in increased overall survival(79).

In dietary flaxseed lignan or oil combined with tamoxifen reduced the growth of estrogen receptor-positive breast tumors (MCF-7) at low circulating estrogen levels by inhibiting cell proliferation, expression of genes, and proteins involved in the ER- and growth factor-mediated signaling pathways(80).

FO induced the greatest effect in increasing apoptosis in compared with TAM treatment alone(80).

Lignans (a class of phytoestrogens) consumption was associated with a significant reduction in breast cancer risk(81).

In estrogen-receptor-positive (MCF-7) and estrogen-receptor-negative (MDA-MB-231) cells, Flaxseed sprouts induced apoptosis and inhibited cancer cell growth by significantly upregulated p53(Anti-tumor antigen) mRNA (transmits genetic information from DNA to the cytoplasm and controls certain chemical processes in the cell) in both cell cancer lines(82).

Taken together, certain vegetables(7)(8) and fruits(9)(10) or their chemical compounds may have a potential and therapeutic effect in the treatment of breast cancer, by blocking the cancer energy sources of the pathways, influencing the signal pathways of the cell proliferation or suppressing the promoted cancers genes.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
1) Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women by Fung TT, Chiuve SE, Willett WC, Hankinson SE, Hu FB, Holmes MD. (PubMed)
(2) Fruits, vegetables, and breast cancer risk: a systematic review and meta-analysis of prospective studies by Aune D, Chan DS, Vieira AR, Rosenblatt DA, Vieira R, Greenwood DC, Norat T.(PubMed)
(3) Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients.
Freudenheim JL, Marshall JR, Vena JE, Laughlin R, Brasure JR, Swanson MK, Nemoto T, Graham S.(PubMed)(4) Lifestyle and risk of development of breast and ovarian cancer by Pięta B, Chmaj-Wierzchowska K, Opala T.(PubMed)
(5) Epidemiological evidence for a relationship between life events, coping style, and personality factors in the development of breast cancer by Butow PN, Hiller JE, Price MA, Thackway SV, Kricker A, Tennant CC. (PubMed)
(6) Epidemiological correlates of breast cancer in South India by Babu GR, Lakshmi SB, Thiyagarajan JA. (PubMed)
(7) Dietary organic isothiocyanates are cytotoxic in human breast cancerMCF-7 and mammary epithelial MCF-12A cell lines by Tseng E, Scott-Ramsay EA, Morris ME.(PubMed)
(8) Breast cancer risk in premenopausal women is inversely associated with the consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype by
(9) Extracts of strawberry fruits induce intrinsic pathways of apoptosis in breast cancer cells and inhibit tumor progression in mice.by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC.(PubMed)
(10) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)
(63) Logical effects of green tea capsule supplementation in pre-surgery postmenopausal breast cancer patients by Yu SS, Spicer DV, Hawes D, Tseng CC, Yang CS, Pike MC, Wu AH(PubMed)
(64) Epigenetic effects of green tea polyphenols in cancer by Henning SM, Wang P, Carpenter CL, Heber D.(PubMed)
(65) Green Tea Catechins: Proposed Mechanisms of Action in Breast Cancer Focusing on The Interplay Between Survival and Apoptosis by Yiannakopoulou EC. (PubMed)
(66)Epigallocatechin-3-gallate inhibits stem-like inflammatory breast cancer cells by Mineva ND, Paulson KE, Naber SP, Yee AS, Sonenshein GE. (PubMed)
(67) Epigallocatechin-3-Gallate (EGCG) inhibits cell proliferation and migratory behavior of triple-negative breast cancer cells by Braicu C, Gherman CD, Irimie A, Berindan-Neagoe I.(PubMed)
(68) Inhibitory effects and molecular mechanisms of selenium-containing tea polysaccharides on human breast cancer MCF-7 cells by He N, Shi X, Zhao Y, Tian L, Wang D, Yang X.(PubMed)
(69) The effects of green tea consumption on incidence of breast cancer and recurrence of breast cancer: a systematic review and meta-analysis by Seely D, Mills EJ, Wu P, Verma S, Guyatt GH. (PubMed)
(70) The red wine phenolics piceatannol and myricetin act as agonists for estrogen receptor alpha in human breast cancer cells by Maggiolini M, Recchia AG, Bonofiglio D, Catalano S, Vivacqua A, Carpino A, Rago V, Rossi R, Andò S.(PubMed)
(71) Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis. by Alshatwi AA.(PubMed)
(72) Inhibition of Caco-2 colon, MCF-7, and Hs578T breast, and DU 145 prostatic cancer cell proliferation by water-soluble black bean condensed tannins by Bawadi HA, Bansode RR, Trappey A 2nd, Truax RE, Losso JN.(PubMed)
(73) Phytochemicals of black bean seed coats: isolation, structure elucidation, and their antiproliferative and antioxidative activities by Dong M, He X, Liu RH. (PubMed)
(74) Inflammation-related signaling pathways implicating TGFβ are revealed in the expression profiling of MCF7 cells treated with fermented soybean, chungkookjang by Hwang JS, Yoo HJ, Song HJ, Kim KK, Chun YJ, Matsui T, Kim HB. (PubMed)
(75) A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma by Kinouchi FL, Maia DC, de Abreu Ribeiro LC, Placeres MC, de Valdez GF, Colombo LL, Rossi EA, Carlos IZ. (PubMed)
(76) Peanut agglutinin inhibits proliferation of cultured breast cancer cells by Marth C, Daxenbichler G.(PubMed)
(77) The influence of dietary lectins on the cell proliferation of human breast cancer cell lines in vitro by Valentiner U, Fabian S, Schumacher U, Leathem AJ. (PubMed)
(78) beta-Sitosterol activates Fas signaling in human breast cancer cells by Awad AB, Chinnam M, Fink CS, Bradford PG. (PubMed)
(79) Dietary flaxseed-trastuzumab interactive effects on the growth of HER2-overexpressing human breast tumors (BT-474) by Mason JK, Fu MH, Chen J, Yu Z, Thompson LU. (PubMed)
(80) Dietary flaxseed lignan or oil combined with tamoxifen treatment affects MCF-7 tumor growth through estrogen receptor- and growth factor-signaling pathways by Saggar JK, Chen J, Corey P, Thompson LU. (PubMed)
(81)Consumption of flaxseed, a rich source of lignans, is associated with reduced breast cancer risk by Lowcock EC, Cotterchio M, Boucher BA. (PubMed)

The Eight Whole Foods Which Potentially Protect the #ProstateGland Against the Risk of #ProstateCancer, Researchers Say

Kyle J. Norton

Prostate cancer is a medical condition characterized by irregular cell growth in the prostate tissue. At the later state, the cancerous cells may travel a distance away from the original site to infect other healthy tissue or organ.
Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during physical (rectum) exams.

The top 8 foods for reducing prostate cancer risk
1. Flaxseed
Flax seed is native to the region of the eastern Mediterranean to India and also known as common flax or linseed. Flax is an erect annual plant, it can grow to 1.2 m tall. The leaves are 20–40 mm long and 3 mm broad.
Enterolactone and enterodiol, mammalian lignans derived from dietary flaxseed may obstruct or delay the progressed prostate cancer cell proliferation via vascular endothelial growth factor(VEGF)-associated pathways(76) and a diet supplemented with 5% flaxseed inhibited the growth and development of prostate cancer in the TRAMP model(77) and lowered prostate cancer proliferation rates associated with biological alterations(78).

2. Vegetable oil
Vegetable oil is a triglyceride extracted from vegetables.
Increased levels of MUFA-rich vegetable oil((including olive oil, canola, or peanut oil)) intake were associated with a progressive reduction in prostate cancer risk(79). Hydrogenated soybean oil (SHSO) showed remarkably strong anticarcinogenic activity against prostate cancer in the rat model and 5% dietary supplementation with SHSO inhibited the growth of prostate cancer by 80% in vivo(80).

3. Honey
The rich golden liquid is the miraculous product made by bees using nectar from flowers. the liquids are considered as one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Chrysin, a natural flavone commonly found in honey, and honey itself showed to exert its antiproliferative effect on PC-3 cells in a dose- and time-dependent manner(81)

4. Chickpea
Garbanzo beans also known as chickpeas are an edible legume of the genus Cicer and the family Fabaceae, with high sources of protein and minerals, native to the Middle East.
7 protease inhibitor concentrates (PICs) isolated from chickpea showed a significant inhibition the LNCaP prostate cancer cells in concentrations tested of 25-400 μg/ml(82).

5. Olive oil
Extra virgin olive oil (EVOO), was found to significantly affect the growth of HCT 116 tumors xenografted in athymic mice(83) and polyphenols, found in extra virgin olive oil (EVOO) exerted chemopreventive effects towards different organ-specific cancers, affecting the overall process of carcinogenesis by inhibition of DNA synthesis, modulation of ROS production, regulation of cell cycle arrest, modulation of survival/proliferation pathways(84).

Moreover, polyphenols application can directly interact with specific steps and/or proteins regulating the apoptotic process in different ways depending on their concentration, the cell system, and the type or stage of the pathological process(85).

6. Black pepper
Black pepper is a flowering vine in the family Piperaceae, used as a spice and seasoning
Piperine, a major alkaloid constituent of black pepper, inhibited the proliferation of LNCaP, PC-3, 22RV1, and DU-145 prostate cancer cells in a dose-dependent manner and induced apoptosis resulted in caspase activation in LNCaP and PC-3 cells(86) and β-caryophyllene oxide (CPO), a sesquiterpene isolated from the essential oil of black pepper(Piper nigrum L.) not only inhibited the constitutive activation of PI3K/AKT/mTOR/S6K1 (anti-apoptosis and increased cell proliferation and nutrient–hormonal signaling network) pathway signaling cascade but also down-regulated the expression of various downstream gene products that mediate cell proliferation (cyclin D1), survival (bcl-2, bcl-xL, survivin, IAP-1, and IAP-2), metastasis (COX-2), angiogenesis (VEGF), and increased the expression of p53 and p21(87).

7. Green tea
Green tea contains more amount of antioxidants than any drinks or foods with the same volume, is the leaves of Camellia sinensis, undergo minimal oxidation during processing, and originated from China.
Green tea catechins (GTCs), a potent chemical constituent containing (-)-epigallocatechin, (-)-epicatechin, (-)-epigallocatechin-3-gallate, (-)-epicatechin-3-gallate, in treatment of are prostate cancer men reduced lower urinary tract symptoms, improved coexistent benign prostate hyperplasia and reached a statistical significance in the case of International Prostate Symptom Scores(88).

In the green tea polyphenols study, epigallocatechin-3-gallate (EGCG) exerted its anti-cancer effect on signaling pathways in PCa(89).

Also a combination of quercetin and green tea showed a significant increase in the inhibition of proliferation, androgen receptor and phosphatidylinositol 3-kinase/Akt signaling(tumor genesis in early stage), and stimulation of apoptosis(90).

In short, Green tea, potent anti-prostate cancer with activities of heritable alterations of gene expression and chromatin organization without changes in DNA sequence-induced multistep processes of carcinogenesis(91) may be considered a natural treatment in vary types of cancer.

8. Fermented soybean products
Fermented soybean products are made from fermenting soybeans and filamentous fungus, along with water and salt after a period of sometimes.
In Japan, the incidence of prostate caner in aging men is low compared with the Western world, suggestion of these results may be the tradition Japanese diet related.
In fact, the Traditional Japanese diet is rich in soybean products and fish against prostate cancer(92).

In China, suggestions of reduced risk of prostate cancer are associated with the consumption of soy foods and isoflavones found abundantly in fermented soybean products(93). Unfortunately, the epidemiological data, linking ferment soybean products to reduced risk of prostate cancer are inconsistent including miso.

The prevalence and widespread of prostate cancer may be diet, demographic, and life style related diseases (94)(95)(96). Suggestions and intentions are for the prevention of prostate cancer to develop in the first place or used in conjunction with conventional medicine in treating the disease.

Eating healthy, with plenty of vegetables and fruits has always been considered as a preventive engagement in human history. "Let foods be your medicine and let medicine be your foods" by Greek physician Hippocrates (460-377 BC).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio science, ISSN 0975-6299.

References
(76) Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer by Azrad M, Vollmer RT, Madden J, Dewhirst M, Polascik TJ, Snyder DC, Ruffin MT, Moul JW, Brenner DE, Demark-Wahnefried W.(PubMed)
(77) Effect of flaxseed supplementation on prostatic carcinoma in transgenic mice BY Lin X, Gingrich JR, Bao W, Li J, Haroon ZA, Demark-Wahnefried W.(PubMed)
(78) Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery by Demark-Wahnefried W, Polascik TJ, George SL, Switzer BR, Madden JF, Ruffin MT 4th, Snyder DC, Owzar K, Hars V, Albala DM, Walther PJ, Robertson CN, Moul JW, Dunn BK, Brenner D, Minasian L, Stella P, Vollmer RT. (PubMed)
(79) Men who consume vegetable oils rich in monounsaturated fat: their dietary patterns and risk of prostate cancer (New Zealand) by Norrish AE, Jackson RT, Sharpe SJ, Skeaff CM.(PubMed)
(80) Selectively hydrogenated soybean oil exerts strong anti-prostate cancer activities by Jung MY, Choi NJ, Oh CH, Shin HK, Yoon SH. (PubMed)
(81) Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3 by Samarghandian S, Afshari JT, Davoodi S.(PubMed)
(82)Chickpea (Cicer arietinum) and other plant-derived protease inhibitor concentrates inhibit breast and prostate cancer cell proliferation in vitro. by Magee PJ, Owusu-Apenten R, McCann MJ, Gill CI, Rowland IR.(PubMed)
(83) Analgesic, anti-inflammatory and anticancer activities of extra virgin olive oil by Fezai M, Senovilla L, Jemaà M, Ben-Attia M(PubMed).
(84) Modulatory effects of polyphenols on apoptosis induction: relevance for cancer prevention by D'Archivio M, Santangelo C, Scazzocchio B, Varì R, Filesi C, Masella R, Giovannini C.(PubMed)
(85) Apoptosis in cancer and atherosclerosis: polyphenol activities by Giovannini C, Scazzocchio B, Varì R, Santangelo C, D'Archivio M, Masella R.(PubMed)
(86) Piperine, a Bioactive Component of Pepper Spice Exerts Therapeutic Effects on Androgen Dependent and Androgen Independent Prostate Cancer Cells by Samykutty A, Shetty AV, Dakshinamoorthy G, Bartik MM, Johnson GL, Webb B, Zheng G, Chen A, Kalyanasundaram R, Munirathinam G.(PubMed)
(87) β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation by Park KR, Nam D, Yun HM, Lee SG, Jang HJ, Sethi G, Cho SK, Ahn KS. (PubMed)
(88) Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study by Bertuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A.(PubMed)
(89) Modulation of signaling pathways in prostate cancer by green tea polyphenols by Khan N, Mukhtar H.(PubMed)
(90)Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea by Wang P, Vadgama JV, Said JW, Magyar CE, Doan N, Heber D, Henning SM. (PubMed)
(91) Epigenetic effects of green tea polyphenols in cancer by Henning SM, Wang P, Carpenter CL, Heber D.(PubMed)
(92) A case-control study of diet and prostate cancer in Japan: possible protective effect of traditional Japanese diet by Sonoda T, Nagata Y, Mori M, Miyanaga N, Takashima N, Okumura K, Goto K, Naito S, Fujimoto K, Hirao Y, Takahashi A, Tsukamoto T, Fujioka T, Akaza H.(PubMed)
(93) Soy and isoflavone consumption in relation to prostate cancer risk in China by Lee MM, Gomez SL, Chang JS, Wey M, Wang RT, Hsing AW. (PubMed)
(94) Soy intake and cancer risk: a review of the in vitro and in vivo data by Messina MJ, Persky V, Setchell KD, Barnes S.(PubMed)
(94) Mediterranean Diet and Prostate Cancer Risk and Mortality in the Health Professionals Follow-up Study by Kenfield SA, Dupre N, Richman EL, Stampfer MJ, Chan JM, Giovannucci EL. (PubMed)
(95) A prospective study of demographics, diet, and prostate canceramong men of Japanese ancestry in Hawaii by Severson RK, Nomura AM, Grove JS, Stemmermann GN.(PubMed)
(96) Alcohol consumption, smoking, and other risk factors and prostate cancer in a large health plan cohort in California (United States) by Hiatt RA, Armstrong MA, Klatsky AL, Sidney S.(PubMed)

12 #FishOmega3 Supplement Adverse Effects, According to Studies

Kyle J. Norton

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deep sea fish, dark-green leafy vegetables, grains, legumes, and nuts,..

Fish oil omega-3 fatty acids, contained mainly eicosapentaenoic acid and docosahexaenoic acid, although the supplement has been found to process some significant effects in the management and treatment of several diseases, many of which are inflammatory in nature. However, the supplement may induce some outlined adverse effects.


1. Altered platelet function
Omage3 fatty acid made from fish may have a strong implication on platelet function due to the presence of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in increased occlusion time and sharply reduced accumulation of fibrin under flow conditions(1)(2).

Therefore, people with normal bleeding problems should avoid taking the supplement(2).

2. Gastrointestinal adverse effects
Although Omega-3 fatty acids may have potential in triglycerides lowering, reduction of inflammatory indices, immunomodulation, and anti-thrombotic effects, particularly in gastro-protective activity. However, when the health supplement is taken together with cortisone may cause gastrointestinal bleeding in the induction of duodenum ulcer.

This result may be attributed by cortisone in increased oxidation in render them pro-inflammatory (3).

Other researchers suggested that overdoses of omega-3 fatty acids may enhance intestinal production and secretion of intestinal alkaline phosphatase (IAP), in induction of the induces changes of gut bacteria composition resulting in decreased lipopolysaccharide production and gut permeability(7).


3. Detrimental Effects on Wound Healing
In the observation of epidermal growth factor receptor (EGFR)-mediated signaling is required for optimal intestinal wound healing, researchers found that during the early response to intestinal wounding, DHA and EPA uniquely delay the activation of key wound-healing processes in the colon through at least in part suppression of EGFR function(4).


4. Increased risk of lipid peroxidation
Omega 3 fatty acids may interact with reactive oxygen species ROS in an increased risk of lipid peroxidation in the induction of ethane expression in human breath(5).


5. Toxin exposure
Omega 3 fatty acid produced by large amounts of fish may result in adverse effects due to the potential presence of environmental toxins such as mercury, polychlorinated biphenyls, dioxins,.... (8).

Moreover, omega-3 fatty acid preparation may undergo oxidation incontribution to patient intolerance and potential toxicity(8).


6, Weight gain
Intake of omega-3 fatties during pregnancy may have a potential effect on induced weight gain of male offspring and poor outcomes associated with high maternal weight gain early in pregnancy(10)..


7. Altered immune function
Omega 3 fatty acids with abundant arachidonic acid, EPA, and DHA contents may alter the balanced pattern of production of eicosanoids and probably also of docosanoids and resolvins, affecting phagocytosis, T-cell signaling, and antigen presentation capability. (11).

8. Glycemic control
According to a randomized double-blind crossover study compared 6 wk of n-3 fatty acid supplementation (12 g fish oil) and corn plus olive oil, long-term intake of 3 fatty acid supplementation expressed in increased glycerol gluconeogenesis in contribution to the deterioration of glycemic control(12).

However, during the 6 weeks of experiment, researchers also found intake of n-3 fatty acid supplementation lowers triacylglycerols in patients with non-insulin-dependent diabetes mellitus without worsening glycemic control(12).

9. Drug interactions
9. 1. Intake of Omega-3 fatty acids may increase the effects of blood thinning medications, including aspirin, warfarin (Coumadin), and clopedigrel due to its anti coagulative activity(13).

9.2. May increase fasting blood sugar levels, thus reducing the effect of blood sugar-lowering medications, such as glipizide (Glucotrol and Glucotrol XL), glyburide (Micronase or Diabeta), glucophage (Metformin)(13).

9.3. Lower the effect of Cholesterol-lowering medications due to the alternation of ratio of good and bad cholesterol(13).


10. Pregnancy and 11. Lactation
Consumption of the nutrients omega-3 fatty acids (omega-3 FA) during pregnancy and lactation is considered beneficial to fetal and infant development. However, according to the animal study by the Wayne State University School of Medicine, Consuming or administering large or inadequate amounts of omega-3 FA during pregnancy and lactation may induce the potential for adverse effects on infant development(6).


12. Impair host resistance to intracellular pathogens
In the study of Wild-type and fat-1 transgenic mice infected with virulent H37Rv M. tuberculosis via the aerosol route, observation of bacteriological and histopathological changes in lungs, researchers suggested that endogenous production of n-3 PUFAs in fat-1 mice increases their susceptibility to tuberculosis due to impaired bacterial control in cells and reduced proinflammatory cytokine secretion, impaired oxidative metabolism, and diminished M. tuberculosis-lysotracker colocalization within phagosomes(9).

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Potential adverse effects of omega-3 Fatty acids in dogs and cats by Lenox CE1, Bauer JE.(PubMed)
(2) Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation byLarson MK1, Tormoen GW, Weaver LJ, Luepke KJ, Patel IA, Hjelmen CE, Ensz NM, McComas LS, McCarty OJ. (PubMed)
(3) Gastrointestinal bleeding after high intake of omega-3 fatty acids, cortisone, and antibiotic therapy: a case study by Detopoulou P1, Papamikos V.(PubMed)
(4) Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing by Turk HF1, Monk JM, Fan YY, Callaway ES, Weeks B, Chapkin RS(PubMed)
(5) Increased levels of ethane, a non-invasive marker of n-3 fatty acid oxidation, in breath of children with attention deficit hyperactivity disorder by Ross BM1, McKenzie I, Glen I, Bennett CP. (PubMed)
(6) Reduced auditory acuity in rat pups from excess and deficient omega-3 fatty acid consumption by the mother by Church MW1, Jen KL, Stafferton T, Hotra JW, Adams BR. (PubMed)
(7) A host-microbiome interaction mediates the opposing effects of omega-6 and omega-3 fatty acids on metabolic endotoxemia by Kaliannan K1, Wang B1, Li XY1, Kim KJ1, Kang JX1. (PubMed)
(8) Safety considerations with omega-3 fatty acid therapy by Bays HE(PubMed)
(9) Transgenic mice enriched in omega-3 fatty acids are more susceptible to pulmonary tuberculosis: impaired resistance to tuberculosis in fat-1 mice by Bonilla DL1, Fan YY, Chapkin RS, McMurray DN.(PubMed)
(10) Maternal Weight Gain Regulates Omega-3 Fatty Acids in Male, Not Female, Neonates by O'Tierney-Ginn PF1, Gillingham M2, Fowler J3, Brass E4, Marshall NE5,6, Thornburg KL(PubMed)
(11) Immunomodulation by omega-3 fatty acids by Calder PC(PubMed).
(12) Dietary supplementation with n-3 fatty acids increases gluconeogenesis from glycerol but not hepatic glucose production in patients with non-insulin-dependent diabetes mellitus by Puhakainen I1, Ahola I, Yki-Järvinen H.(PubMed)
(13) Possible Interactions with Omega-3 Fatty Acids by Penn state University

The Coffee #AntiAging Effect on #ChromosomeTelomereLength, Studies Show

Kyle J. Norton

Epidemiological evidence suggested that lifestyle factors may affect the health and lifespan of an individual through the expression of telomere length.

And intake of coffee daily and moderately may be one of them

Coffee, second to tea consumption, is a popular and social beverage all over the world, particularly in the West, made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar

Intake of coffee may have a profound effect in strengthening the telomere length, a biomarker of living longer, a renowned study suggested.

In a cross-sectional association between coffee consumption and telomere length in 4780 women, using the data from the Nurses’ Health Study (NHS) from a prospective cohort study of female nurses began in 1976 with relative telomere length measured in peripheral blood leukocytes by the quantitative real-time polymerase chain reaction, after adjusting to other risk factors, researchers found that
* Higher total coffee use was significantly associated with longer telomeres compared to nondrinkers

* Intake of 2 to <3 and ≥3 cups of coffee/d showed a relative ratio of 1.29 and 1.36, respectively

* Telomere length was associated linearly with caffeine consumption from all dietary sources

The result of the findings showed a strong indication of a correlation between coffee caffeine intake and the length of telomeres among female nurses.

Dr. Liu JJ, the lead author said, “ ... better understand the influence of coffee consumption on telomeres, which may uncover new knowledge of how coffee consumption affects health and longevity”.

Other, in a study of a total of 5826 adults from the National Health and Nutrition Examination Survey (NHANES) cross-sectionally, using the quantitative polymerase chain reaction method, telomere length compared to standard reference DNA, after adjusting to other risk factors, including age, gender, race, marital status, education, housing, smoking, BMI, physical activity, alcohol use,.. researchers showed that
* Caffeine consumption was inversely related to telomere length
* For each 100 mg of caffeine consumed, telomeres were 35.4 base pairs shorter
* For each 100 mg of caffeine consumed among coffee drinkers only, telomeres were 36.7 base pairs shorter
* Among non-coffee drinkers only, 40.0 base pairs shorter

Compared to non-drinker (40.0 base pairs shorter), coffee caffeine( 36.7 base pairs shorter) and caffeine( 35.4 base pairs shorter) intake expressed a positive effect in increased genetic telomeres length.

Taking it all together, coffee (regardless caffeinated or not and the number of cups intake per day) expressed a significant effect in increased telomeres length, the DNA implication of living longer in both genders.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it’s news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Coffee Consumption Is Positively Associated with Longer Leukocyte Telomere Length in the Nurses’ Health Study by Liu JJ1, Crous-Bou M2, Giovannucci E3, De Vivo I4. (PubMed)
(2) Caffeine consumption and telomere length in men and women of the National Health and Nutrition Examination Survey (NHANES) by Tucker LA1.(PubMed)

Eight Anti #BreastCancer Vegetables, According to Studies

By Kyle J. Norton

The prevalence of breast cancer has been acknowledged in the scientific community worldwide.
Breast cancer is widespread in women in Southeast Asia as a result of over 2 decades of economic prosperity caused by an unhealthy diet is a major concern.

The findings for effective treatments are ongoing with some successes, but the discovery of effective ingredients prevention and treatment of breast cancer with little or no side effects have proven difficult.

According to statistics, the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Detection of tumorigenesis through self-observation is still the best approach to discovering breast cancer in the early stage.

But the reduction of the mortality at late stage discovered breast cancer has not been accounted for, even with extensively modern technology in the field of diagnosis and insurance protection in the Western world, needless to say of those countries with poor health care systems.

Suggestions of a healthy diet with plenty of vegetables and fruits(1)(2)(3) accompanied with a change of lifestyle (4)(5)(6) may be the only choice for women in reducing the risk of the disease.

In fact, certain vegetables(7)(8), fruits(9)(10), and bioactive phytochemicals found in foods(23)(24) and herbs(33)(34) have been found to induce apoptosis and anti-proliferation of breast cancer cells by blocking the energy sources to the tumor site and suppressing the promoted cancers genes.

1. Cruciferous vegetables
Cruciferous vegetables are a group of vegetable belongings to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.

Isothiocyanate (ITC), one of the major chemical constituents found in cruciferous vegetables has been studied extensively over the past three decades with evidence against breast cancer in preclinical models.

Benzyl isothiocyanate, the derivative of isothiocyanate displayed a significant efficacy in inhibited carcinogen metabolism and signaling pathways relevant to tumor progression and invasion(11) against MDA-MB-231(breast cancer cell line), human breast cancer xenografts(mutation tissues)(12) by suppressing X-linked inhibitor of apoptosis (XIAP) protein expression of cancer cell line MCF-7 and reduced levels of mutations of p53(antigens) protein level(13).

Loss of normal function of p53 gene was associated with over 50% of cancer patients and mutation p53 gene may have an oncogenic potential.


In Her-2 positive (a most aggressive case of breast cancer), indole-3-carbinol, a naturally occurring compound found in cruciferous vegetables, used combination with paclitaxel (a mitotic inhibitor) synergistically inhibited growth of Her2/neu human breast cancer cells by cancer cells cycle arrest in the G2(pre-mitotic phase) and M(nuclear division) phase and induced apoptosis/necrosis(14).

I3C used alone also inhibited Her-2breast cancer cell growth in a dose-dependent manner as the compound promoted the production of Bax(an apoptosis promoter) and decreased expression of Bcl-2(an apoptosis inhibitor) and, thereby, increased the ratio of Bax to Bcl-2 in favoring apoptosis(15).

2. Tomatoes
Tomato is red, edible fruit, genus Solanum, belongings to the family Solanaceae, native to South America. Because of its health benefits, tomato is grown worldwide for commercial purpose and often in a greenhouse.

Lycopene, a major carotenoid component of tomato has been known in the research community with the property to attenuate the risk of breast cancer.

In a time and dose-dependent, the compound showed an anti-proliferative activity against ER(estrogen receptor)/PR(progesterone receptor) positive MCF-7, HER2-positive SK-BR-3, and triple-negative MDA-MB-468 cell lines by arresting cell cycle at the G0 /G1phase(interphase together - chromosomes replicate in preparation for cell division) at physiologically achievable concentrations(range) found in human plasma(16)

Lycopene also Inhibited the ER-positive MCF-7 through cell cycle progression, and ER-negative MDA-MB-231 cells through G1 phase cell cycle arrest (17).

Application of lycopene not only restored the GSTP1 expression but also at 2 microM, once per week for 2 weeks induced demethylation of RARbeta2 (tumor suppressor gene) and the HIN-1(a cell growth inhibitor)) genes in the non cancer MCF10A fibrocystic breast cells(18).

3. Figs
N-hexane insoluble fraction (HIF) found in figs may be lesser known for its efficacy in breast cancer cell suppressive activity.

The combination of HIF and doxorubicin exerted a greater inhibition on cell growth in (Human ductal breast epithelial tumor cell line) T47D cells and increased the incidence of cells undergoing apoptosis, in compared to doxorubicin alone(19).

The soluble fraction (Ethyl acetate soluble fraction (EASF)) in Fig leave was also found to enhance the cytotoxic effect of doxorubicin by changing the inhibition of cell cycle G(2)/M to G(1) phase(20).

And Acetone extract of Ficus religosa leaf (FAE) demonstrated an irreversible inhibition of breast cancer cell growth with moderate toxicity by stimulating the loss of mitochondrial membrane potential in multiple breast cancer cell lines and accelerated cell death through the photosensitizing effect(21).

4. Garlic
Garlic is a natural superfood healer for its antibiotic antiviral, antifungal, anticoagulant, and antiseptic properties.

Diallyl trisulfide(DAS), a derived organosulfur compound (OSCs) suppressed the ratio of viable cells in the culture of (Human breast cancer cell line) MCF-7 and MCF-12a (a non-tumorigenic epithelial cell line) by decreasing the percent of cancer cells in phase G(2)/M and induced apoptotic cell death through a stimulated function of Bax protein and p53(cellular tumor antigen) protein expression(22).

The application of DAS also enhanced the effect of eicosapentaenoic acid, a breast cancer suppressor, and decreased the effect of linoleic acid, a breast cancer enhancer, and reduced the side effects caused by anti-cancer agents(23).

Protein fraction from garlic was effective in inhibiting tumor growth more efficiently than garlic extract in enhancing the CD8(+) T-cell infiltration into the tumor site(24).

5. Spinach
Spinach, an edible flowering plant in the genus Spinacia, belongings to the family of Amaranthaceae, is considered a healthy plant containing various vitamins and minerals, native to central and southwestern Asia.

Consuming spinach was found to exhibit a significant protective effect on breast cancer among premenopausal women(25).

Eating carrots or spinach more than twice weekly, compared with no intake, was associated with an odds ratio of 0.56 but did not distinguish among several potential explanations for the protective association observed between intake of carrots and spinach and risk of breast cancer.(26).

It is said that including supplementation of A. gangeticus aqueous extract of red spinach at 10% reduced the progression of breast cancer in rat models (27).

6. Kelp
Kelps are large seaweeds (algae) growing shallow in underwater oceans belongings to the class Phaeophyceae in the order Laminariales, used for food in many cultures.

Laminaria, a brown kelp seaweed containing antibiotic substance, 1-3 beta-glucan, was effective in activating a host-mediated immune response in preventing the initiation of breast cancer(28).

Japanese seaweed (Laminaria angustata) extracts were also found to exert antimutagenic effects in certain breast and colon carcinogens (29).

L-tryptophane substances isolated from the kelp rhizoid, may play an important role in the inhibition of breast cell proliferation(30)(31).

7. Chili pepper
Chili pepper is the fruit of a plant from the genus Capsicum, belongings to the nightshade family, Solanaceae, used in human history for spices and cultivated for commercial profits.

Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a chemical constituent of chili peppers used in many cultures as an anti-cancer agent inhibited the growth of ER-positive (MCF-7, T47D, BT-474) and ER-negative (SKBR-3, MDA-MB231) breast cancer cell lines, reduced 50% the size of MDA-MB231 breast cancer tumors(32), through inducing cellular apoptosis via a caspase-independent pathway in MCF-7 cells(33).

In the comparison of Dohevanil, researchers found that both vanilloids, a precursor of capsaicin and dohevanil inhibited the growth of DNA fragmentation in MCF-7 cells(34).

8. Carrot
A carrot is a root vegetable with orange color normally, a subspecies of Daucus carota, belongings to the family Apiaceae, and native to Asia and Europe.

Intake of cruciferous vegetables and carrot are inversely associated with risk of estrogen receptor-negative/progesterone receptor-negative breast cancer(35).

Wild carrot or Daucus carota L. ssp. carota (Apiacea) oil extract, used in traditional medicine in Lebanon and different regions throughout the world was found to inhibit human colon (HT-29, Caco-2) and breast (MCF-7, MDA-MB-231) cancer cell lines, through apoptotic and anti-proliferative activities(36).

The information findings once again emphasized the importance of a healthy diet with plenty of vegetables and fruits and a change of lifestyle in breast cancer risk.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
1) Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women by Fung TT, Chiuve SE, Willett WC, Hankinson SE, Hu FB, Holmes MD. (PubMed)
(2) Fruits, vegetables, and breast cancer risk: a systematic review and meta-analysis of prospective studies by Aune D, Chan DS, Vieira AR, Rosenblatt DA, Vieira R, Greenwood DC, Norat T.(PubMed)
(3) Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients.
Freudenheim JL, Marshall JR, Vena JE, Laughlin R, Brasure JR, Swanson MK, Nemoto T, Graham S.(PubMed)(4) Lifestyle and risk of development of breast and ovarian cancer by Pięta B, Chmaj-Wierzchowska K, Opala T.(PubMed)
(5) Epidemiological evidence for a relationship between life events, coping style, and personality factors in the development of breast cancer by Butow PN, Hiller JE, Price MA, Thackway SV, Kricker A, Tennant CC. (PubMed)
(6) Epidemiological correlates of breast cancer in South India by Babu GR, Lakshmi SB, Thiyagarajan JA. (PubMed)
(7) Dietary organic isothiocyanates are cytotoxic in human breast cancerMCF-7 and mammary epithelial MCF-12A cell lines by Tseng E, Scott-Ramsay EA, Morris ME. (PubMed)
(8) Breast cancer risk in premenopausal women is inversely associated with the consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype by
(9) Extracts of strawberry fruits induce an intrinsic pathway of apoptosis in breast cancer cells and inhibit tumor progression in mice.by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC.(PubMed)
(10) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)
(11) Benzyl isothiocyanate: double trouble for breast cancer cells by Rao CV. (PubMed)
(12) Inhibition of human breast cancer xenograft growth by cruciferous vegetable constituent benzyl isothiocyanate by Warin R, Xiao D, Arlotti JA, Bommareddy A, Singh SV. (PubMed)
(13) p53-Independent apoptosis by benzyl isothiocyanate in human breast cancer cells is mediated by suppression of XIAP expression by Kim SH, Singh SV. (PubMed)
(14) 3,3'-diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2/Neu human breast cancer cells by McGuire KP, Ngoubilly N, Neavyn M, Lanza-Jacoby S.(PubMed)
(15) Translocation of Bax to mitochondria induces apoptotic cell death in indole-3-carbinol (I3C) treated breast cancer cells by Rahman KM, Aranha O, Glazyrin A, Chinni SR, Sarkar FH.(PubMed)
(16) Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines by Takeshima M, Ono M, Higuchi T, Chen C, Hara T, Nakano S.(PubMed)
(17) [Effect of lycopene on the proliferation of MCF-7 and MDA-MB-231 cells].
[Article in Chinese] by Wang AH, Zhang LS. (PubMed)
(18) Modulation of gene methylation by genistein or lycopene in breast cancer cells, by King-Batoon A, Leszczynska JM, Klein CB. (PubMed)
(19) Combinational effects of hexane insoluble fraction of Ficus septica Burm. F. and doxorubicin chemotherapy on T47D breast cancer cells by Nugroho AE, Hermawan A, Putri DD, Novika A, Meiyanto E, Kawaichi M.(PubMed)(20) Synergistic effects of ethyl acetate fraction of Ficus septica Burm. f. and doxorubicin chemotherapy on T47D human breast cancer cell line by Nugroho AE, Hermawan A, Putri D P, Meiyanto E, Hakim L.(PubMed)
(21) Bax translocation mediated mitochondrial apoptosis and caspase-dependent photosensitizing effect of Ficus religiosa on cancer cells by Haneef J, Parvathy M, Thankayyan R SK, Sithul H, Sreeharshan S.(PubMed)
(22) Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells by Malki A, El-Saadani M, Sultan AS.(PubMed)
(23) Anticancer effects of garlic and garlic-derived compounds for breast cancer control.
Tsubura A, Lai YC, Kuwata M, Uehara N, Yoshizawa K.(PubMed)(24) Purified Protein Fraction of Garlic Extract Modulates Cellular Immune Response against Breast Transplanted Tumors in BALB/c Mice Model by Ebrahimi M, Mohammad Hassan Z, Mostafaie A, Zare Mehrjardi N, Ghazanfari T.(PubMed)
(25) Food sources of phytoestrogens and breast cancer risk in Mexican women by Torres-Sánchez L, López-Carrillo L, López-Cervantes M, Rueda-Neria C, Wolff MS.(PubMed)
(26) Intake of carrots, spinach, and supplements containing vitamin A in relation to risk of breast cancer byLongnecker MP, Newcomb PA, Mittendorf R, Greenberg ER, Willett WC(PubMed)
(27) Potential anticancer effect of red spinach (Amaranthus gangeticus) extract by Sani HA, Rahmat A, Ismail M, Rosli R, Endrini S.(PubMed)
(28) The dietary intake of Laminaria, a brown seaweed, and breast cancer prevention by Teas J.(PubMed)
(29) Effect of Japanese seaweed (Laminaria angustata) extracts on the mutagenicity of 7,12-dimethylbenz[a]anthracene, a breast carcinogen, and of 3,2'-dimethyl-4-aminobiphenyl, a colon and breast carcinogen by Reddy BS, Sharma C, Mathews L.(PubMed)
(30) Indoleamine 2,3-dioxygenase activity and L-tryptophan transport in human breast cancer cells.
Travers MT, Gow IF, Barber MC, Thomson J, Shennan DB.(PubMed)
(31) [Substance isolated from the kelp rhizoid identified as L-tryptophan shows high inhibition of breast cancer].[Article in Japanese] by Takahashi N, Ojika M, Dogasaki C, Nishizawa M, Fukuoka H, Sahara H, Sato N, Mori M, Kikuchi K.(PubMed)
(32) Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway by Thoennissen NH, O'Kelly J, Lu D, Iwanski GB, La DT, Abbassi S, Leiter A, Karlan B, Mehta R, Koeffler HP.(PubMed)
(33) Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through the caspase-independent pathway by Chou CC, Wu YC, Wang YF, Chou MJ, Kuo SJ, Chen DR.(PubMed)
(34) Apoptosis induction by dohevanil, a DHA substitutive analog of capsaicin, in MCF-7 cells by Tuoya, Baba N, Shimoishi Y, Murata Y, Tada M, Koseki M, Takahata K.(PubMed)
(35) Fruit and vegetable intake in relation to risk of breast cancer in the Black Women's Health Study. by Boggs DA, Palmer JR, Wise LA, Spiegelman D, Stampfer MJ, Adams-Campbell LL, Rosenberg L.(PubMed)
(36) The antioxidant and anticancer effects of wild carrot oil extract by Shebaby WN, El-Sibai M, Smith KB, Karam MC, Mroueh M, Daher CF. (PubMed)

#Herbal #Dandelion Inhibits Parameters Associated with the Risk of #MetabolicSyndrome, Researchers Show

Kyle J. Norton

A metabolic syndrome is a group of conditions associated with an increased risk of cardiovascular disease and types 2 diabetes, including high blood pressure, sugar, cholesterol, triglyceride levels, and excess body fat around the waist.

Cardiovascular diseases refer to heart diseases, affecting millions of people in the world. According to statistics, over 17.7 million people died from CVDs in 2015, Hyperlipidaemia and hypertension are the risk factors for the diseases.

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate glucose.

In other words, diabetes occurs when cells in the pancreas die off or receptor sites are clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

According to statistics, metabolic syndrome is growing prevalent in the Western world, In the US, 30% of Americans are living with metabolic syndrome,

In other words, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.

The CDC statistic suggested, that among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35% from 25.3% to 34.2% according to the data from 1988–1994 to 2007–2012.

The most common metabolic syndrome are age, family history of metabolic syndrome, physical activity, and women diagnosed with polycystic ovary syndrome.

Symptoms of signs of metabolic syndrome depend on the types of affected conditions and complications.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver, and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, heart weakness, chronic joint, skin diseases, etc.

In finding a natural ingredient for the prevention and treatment of cardiovascular diseases, scientists examined the effects of Boldocynara® (Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus) as a combination product and its individual extracts on key enzymes relevant to metabolic syndrome.

According to the tested differentiation, the combination exerted moderate to weak effects on the tested liver enzymes against metabolic syndrome.

In the individual herb analysis, * Peumus boldus extract exhibited pronounced inhibitory activities on α-glucosidase (80% inhibition at 100 µg/ml, IC50: 17.56 µg/ml) associated with a metabolic modifier that could reduce the risk of CVD in patients with the metabolic syndrome.

* Silybum marianum had moderate pancreatic lipase (PL) inhibitory activities (30% at 100 µg/ml) involved in lipid metabolism disorder.

* Cynara scolymus showed moderate ACE inhibitory activity (31% at 100 µg/ml) in reducing the risk of CVD.

In other words, all individual herbal medicine work synergistically to induce inhibitory activity against all parameters in inducing the risk of metabolic syndrome.

Based on the results, researchers suggest, " our results indicate some moderate potential of the dietary supplement Boldocynara® and its single ingredients for the prevention of metabolic disorders".


Taken altogether, Dandelion used in combination with other herbs may be considered a formula for the prevention of metabolic syndrome, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) In vitro inhibitory potential of Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus on key enzymes relevant to metabolic syndrome by Villiger A1, Sala F1, Suter A2, Butterweck V. (PubMed)