Kyle J. Norton
A recent study suggested that essential oil isolated from Chaste tree berries may have a potential effect in reduced neuro-pain through antinociceptive function in tested subjects.
The antinociceptive effect is the activity of reduced pain through interference with information transmitted and received by brain neurons.
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.
In the study of three behavioral models of nociception in adult male Wistar rats conducted by the University of Tabriz, the topical essential oil extracted from Vitex Agnus-cactus (EOVAC) was applied to animals expressed a reduced pain response in tail immersion tests, inhibited the acetic acid-induced writhing response with little adverse effects.
Dr. Khalilzadeh E, the lead author said, " major components of the EOVAC were α-pinene (14.83%), limonene (10.29%), β-caryophyllene (6.9%), sabinene (5.27%), and β-farnesene (5.9%), (may have direct influence to the) endogenous opioidergic system, as well as muscarinergic receptors of the cholinergic system, may be involved in the antinociceptive activity of Vitex agnus-castus essential oil in these models of pain in rats".
Interestingly, the extract of herbal medicine also displayed a strong effect against chronic inflammation in induced pain.
The joint study led by the Federal University of Santa Maria suggested that crude extract caused antinociceptive/antidepressant-like effects in the CFA-induced chronic inflammation model incomparable to naloxone, without altered inflammatory parameters at doses of 10mg/kg,
This result indicated that The VmE extract demonstrated pain relief by inducing opioid-dependent antinociception and antidepressant-like effects, without anti-inflammatory activity.
Furthermore, in the investigated petroleum ether fraction (PEF) from the aqueous ethanol extract of Chaste tree berry in several nociceptive mouse models, mouses treated with the fraction produced significant dose-related inhibitions on chemical nociception incomparable to Naloxone (1 mg/kg BW subcutaneously), a non-selected opioid receptor antagonist.
In the xylene-induced ear edema test, the fraction also exerted strong analgesic effects partially mediated by its anti-inflammatory activity.
Taking together, Chaste tree berries may have a therapeutic potential to be used as an antinociceptive functional food in reduced pain by blocking the information transfer by neurotransmitters.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Antinociceptive effects, acute toxicity and chemical composition of Vitex agnus-castus essential oil by Khalilzadeh E, Vafaei Saiah G, Hasannejad H, Ghaderi A, Ghaderi S, Hamidian G, Mahmoudi R, Eshgi D, Zangisheh M.(PubMed)
(2) Antinociceptive and antidepressant-like effects of the crude extract of Vitexmegapotamica in rats by Hamann FR1, Zago AM2, Rossato MF3, Beck VR4, Mello CF4, de Brum TF5, de Carvalho LM6, Faccin H6, Oliveira SM7, Rubin MA8(PubMed)
(3) Antinociceptive activities of the liposoluble fraction from Vitex negundo seeds by Zheng CJ1, Huang BK, Han T, Zhang QY, Zhang H, Rahman K, Qin LP. (PubMed)
Monday, 10 July 2023
#Turmeric's #Curcumin Exerts Anti-Inflammatory and Cardioprotective Properties Against the Onset of #ChagasHeartDisease, Researchers Show
Kyle J. Norton
Chagas disease (CD) is a medical condition caused by the protozoan parasite Trypanosoma cruzi.
According to the statistics, approximately 6 million people worldwide are living with Chagas disease. The majority of patients reside in Mexico, Central America, and South America,
Chagas heart disease can be classified into
* Acute Chagas heart disease is characterized by the inflammation of the heart, gastrointestinal tract (mainly esophagus and colon), meninges, and central and peripheral nervous tissues. Untreated symptomatic patients in this phase may face a roughly 1% chance of death in the acute period, usually the result of severe myocarditis or meningoencephalitis
* The indeterminate form of Chagas heart disease is characterized by small foci of mild chronic myocarditis, with interstitial edema, early fibrosis, and infiltration by lymphocytes, macrophages, and plasma cells. Most patients with the indeterminate form will progress to the chronic form of Chagas heart disease such as dilated cardiomyopathy, at a rate of 1.85% to 7% annually.
* The chronic form of Chagas heart disease is characterized by cardiomegaly and increased cardiac mass, thinning of the ventricular walls, and aneurysmal lesions in various regions of the LV and right ventricle (RV).
Dr. Edimar Alcides Bocchi, the lead scientist in the treatment of Chagas heart disease wrote, "Pharmacological treatment and antiarrhythmic therapy for ChHD is mostly based on results for other etiologies. Heart transplantation is an established, valuable therapeutic option in refractory ChHD".
And, "Implantable cardioverter-defibrillators are indicated for the prevention of secondary sudden cardiac death. Specific etiological treatments should be revisited and reserved for select patients. Understanding and management of ChHD need improvement, including the development of randomized trials".
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential compound for the treatment of Chagas heart disease, caused by the protozoan parasite Trypanosoma cruzi., researchers examined the anti-inflammatory and cardioprotective properties of curcumin (Cur).
The study included oral therapy with Cur on T. cruzi-mediated cardio-vasculopathy in acutely infected mice and in vitro, the response of parasite-infected human microvascular endothelial cells treated with this phytochemical.
According to the tested assays, oral Cur therapy showed a reduced inflammatory cell infiltration of myocardial arteries without lowering parasite levels in the tested infected mice.
Furthermore, mice treated with Cur showed significantly decreased vessel inflammation scores (p < 0.001), and vascular permeabilities compared to mice treated with the phosphate-buffered saline-receiving group.
Moreover, levels of pro-inflammatory cytokines and ET-1 secretion involved in vascular constriction were also inhibited by the treatment of Cur.
Additionally, proteins and signaling pathways that promote the generation of inflammatory agents are also inhibited by the injection of Cur.
In other words, curcumin (Cur) exerted the anti-inflammatory and cardioprotective properties against parasite-induced the onset of Chagas heart disease.
Based on the findings researchers wrote, "These findings identify new perspectives for exploring the potential of Cur-based interventions to ameliorate Chagas heart disease".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of Chagas heart disease, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumolide reduces diabetic retinal vascular leukostasis and leakage partly via inhibition of the p38MAPK/NF-κ B signaling by Cai Y1, Li W1, Tu H1, Chen N1, Zhong Z1, Yan P1, Dong J. (PubMed)
(2) Curcumin exerts anti-inflammatory and vasoprotective effects through amelioration of NFAT-dependent endothelin-1 production in mice with acute Chagas cardiomyopathy by Hernández M1, Wicz S1, Santamaría MH2, Corral RS. (PubMed)
(3) Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management A Scientific Statement From the American Heart Association. (Circulation)
(4) Chronic Chagas Heart Disease Management
From Etiology to Cardiomyopathy Treatment by Edimar Alcides Bocchi, Reinaldo Bulgarelli Bestetti, Mauricio Ibrahim Scanavacca, Edecio Cunha Neto and Victor Sarli Issa. (JACC)
Chagas disease (CD) is a medical condition caused by the protozoan parasite Trypanosoma cruzi.
According to the statistics, approximately 6 million people worldwide are living with Chagas disease. The majority of patients reside in Mexico, Central America, and South America,
Chagas heart disease can be classified into
* Acute Chagas heart disease is characterized by the inflammation of the heart, gastrointestinal tract (mainly esophagus and colon), meninges, and central and peripheral nervous tissues. Untreated symptomatic patients in this phase may face a roughly 1% chance of death in the acute period, usually the result of severe myocarditis or meningoencephalitis
* The indeterminate form of Chagas heart disease is characterized by small foci of mild chronic myocarditis, with interstitial edema, early fibrosis, and infiltration by lymphocytes, macrophages, and plasma cells. Most patients with the indeterminate form will progress to the chronic form of Chagas heart disease such as dilated cardiomyopathy, at a rate of 1.85% to 7% annually.
* The chronic form of Chagas heart disease is characterized by cardiomegaly and increased cardiac mass, thinning of the ventricular walls, and aneurysmal lesions in various regions of the LV and right ventricle (RV).
Dr. Edimar Alcides Bocchi, the lead scientist in the treatment of Chagas heart disease wrote, "Pharmacological treatment and antiarrhythmic therapy for ChHD is mostly based on results for other etiologies. Heart transplantation is an established, valuable therapeutic option in refractory ChHD".
And, "Implantable cardioverter-defibrillators are indicated for the prevention of secondary sudden cardiac death. Specific etiological treatments should be revisited and reserved for select patients. Understanding and management of ChHD need improvement, including the development of randomized trials".
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential compound for the treatment of Chagas heart disease, caused by the protozoan parasite Trypanosoma cruzi., researchers examined the anti-inflammatory and cardioprotective properties of curcumin (Cur).
The study included oral therapy with Cur on T. cruzi-mediated cardio-vasculopathy in acutely infected mice and in vitro, the response of parasite-infected human microvascular endothelial cells treated with this phytochemical.
According to the tested assays, oral Cur therapy showed a reduced inflammatory cell infiltration of myocardial arteries without lowering parasite levels in the tested infected mice.
Furthermore, mice treated with Cur showed significantly decreased vessel inflammation scores (p < 0.001), and vascular permeabilities compared to mice treated with the phosphate-buffered saline-receiving group.
Moreover, levels of pro-inflammatory cytokines and ET-1 secretion involved in vascular constriction were also inhibited by the treatment of Cur.
Additionally, proteins and signaling pathways that promote the generation of inflammatory agents are also inhibited by the injection of Cur.
In other words, curcumin (Cur) exerted the anti-inflammatory and cardioprotective properties against parasite-induced the onset of Chagas heart disease.
Based on the findings researchers wrote, "These findings identify new perspectives for exploring the potential of Cur-based interventions to ameliorate Chagas heart disease".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of Chagas heart disease, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumolide reduces diabetic retinal vascular leukostasis and leakage partly via inhibition of the p38MAPK/NF-κ B signaling by Cai Y1, Li W1, Tu H1, Chen N1, Zhong Z1, Yan P1, Dong J. (PubMed)
(2) Curcumin exerts anti-inflammatory and vasoprotective effects through amelioration of NFAT-dependent endothelin-1 production in mice with acute Chagas cardiomyopathy by Hernández M1, Wicz S1, Santamaría MH2, Corral RS. (PubMed)
(3) Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management A Scientific Statement From the American Heart Association. (Circulation)
(4) Chronic Chagas Heart Disease Management
From Etiology to Cardiomyopathy Treatment by Edimar Alcides Bocchi, Reinaldo Bulgarelli Bestetti, Mauricio Ibrahim Scanavacca, Edecio Cunha Neto and Victor Sarli Issa. (JACC)
The #Estrogenic Effects of Herbal #Fennels and Fennel Seeds, According to Studies
Kyle J. Norton
Fennel may have a potential effect in increased plant base estrogenic levels in reduced risk of estrogen-related diseases, some scientists suggested.
Estrogen is a primary female sex hormone, responsible for the development and regulation of the female reproductive system and secondary sex characteristics.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the evaluation of the fennel estrogenic effect in inhibiting the increased ectopic uterine motility in facilitated symptoms including pain in primary dysmenorrhea, researchers found that compared to non-steroidal anti-inflammatory drugs (NSAIDs) in the induction of severe adverse effects used for treatment in long-term therapy, application of fennel essential oil (FEO) of LD(50, 1326 mg/kg) in a rat model, exerted a therapeutic effect in reduced expression of prostaglandin E(2) (PGE(2)) in induced muscle contraction.
Further analysis suggested that fennel essential oil reduced the intensity of oxytocin and PGE(2) induced uterine muscle contractions significantly (25 and 50 microg/ml for oxytocin and 10 and 20 microg/ml PGE(2), respectively without inducing mortality in tested subjects.
Abnormal production of prostaglandins E2 was found to associate with the intensity of symptoms of primary dysmenorrhea, including vomiting, fever, diarrhea, and excessive uterine contraction.
According to the P. G. Institute of Basic Medical Sciences, acetone extract isolated from Foeniculum vulgare Mill., seeds at different dose levels (50/ug, 150/ug, and 250/ug/100gm body wt.) exerted a potential and positive estrogenic activity in increased nucleic acids and protein concentration and organ weights, particularly in the medium and high doses.
The above differentiation was supported by the study of "Effect of Foeniculum vulgare Mill. seed extract on the genital organs of male and female rats" conducted by Dr. Malini T and colleagues.
According to the results, the fennel estrogenic effect in oral administration of acetone extract of Foeniculum vulgare (fennel) seeds for 15 days in male rats, exerted a significant malformation of the male reproductive tract including decreased in testes through inhibited Leydig cell production of testosterone and disrupted fluid reabsorption in the efferent ductules via the ERα and vas deferens in transported sperm from the testicle to the urethra.
Moreover, the application of the extract also demonstrated an increased volume of seminal vesicles and the prostate gland and decreased activities of acid and alkaline phosphatase in all these regions, including bones, intestines, pancreas, and kidneys.
In female rats, ingestion of acetone extract for 10 days showed a strong effect in the expression of estrogenic effect through the observation by vaginal cornification, the test of the appearance of cornified epithelial cells in a vaginal smear for confirmation of the presence of high estrogen levels.
The application also catalyzed the imbalanced production of sex hormones in the female estrus cycle.
At moderate doses, the seeds caused an increase in the weight of mammary glands by overexpression of estrogen circulation precipitated a negative effect in regulated systemic myogenic factors (prolactin, growth hormone) and directed influence of the mammary tissue, such as stromal components and epithelial cells.
At higher doses, fennel seeds increased the weight of the oviduct, endometrium, myometrium, cervix, and vagina.
Taken together, fennel may be considered a functional food for reduced symptoms of estrogen deficiency syndrome and combined with the standard medicine for the treatment of estrogenic-related diseases.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Effect of Foeniculum vulgare Mill. seed extract on the genital organs of male and female rats by Malini T, Vanithakumari G, Megala N, Anusya S, Devi K, Elango V.(PubMed)
(2) Primary dysmenorrhoea: the importance of both prostaglandins E2 and F2 alpha by Lumsden MA, Kelly RW, Baird DT. (PubMed)
(2) Effect of foeniculum vulgare seed extract on mammary glands and oviducts of ovariectomized rats by Devi K1, Vanithakumari G, Anusya S, Mekala N, Malini T, Elango V.(PubMed)
(3) Fennel and anise as estrogenic agents by Albert-Puleo M.(PubMed)
(4) The effect of fennel essential oil on uterine contraction as a model for dysmenorrhea, pharmacology and toxicology study by Ostad SN1, Soodi M, Shariffzadeh M, Khorshidi N, Marzban H.(PubMed)
(5) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
Fennel may have a potential effect in increased plant base estrogenic levels in reduced risk of estrogen-related diseases, some scientists suggested.
Estrogen is a primary female sex hormone, responsible for the development and regulation of the female reproductive system and secondary sex characteristics.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the evaluation of the fennel estrogenic effect in inhibiting the increased ectopic uterine motility in facilitated symptoms including pain in primary dysmenorrhea, researchers found that compared to non-steroidal anti-inflammatory drugs (NSAIDs) in the induction of severe adverse effects used for treatment in long-term therapy, application of fennel essential oil (FEO) of LD(50, 1326 mg/kg) in a rat model, exerted a therapeutic effect in reduced expression of prostaglandin E(2) (PGE(2)) in induced muscle contraction.
Further analysis suggested that fennel essential oil reduced the intensity of oxytocin and PGE(2) induced uterine muscle contractions significantly (25 and 50 microg/ml for oxytocin and 10 and 20 microg/ml PGE(2), respectively without inducing mortality in tested subjects.
Abnormal production of prostaglandins E2 was found to associate with the intensity of symptoms of primary dysmenorrhea, including vomiting, fever, diarrhea, and excessive uterine contraction.
According to the P. G. Institute of Basic Medical Sciences, acetone extract isolated from Foeniculum vulgare Mill., seeds at different dose levels (50/ug, 150/ug, and 250/ug/100gm body wt.) exerted a potential and positive estrogenic activity in increased nucleic acids and protein concentration and organ weights, particularly in the medium and high doses.
The above differentiation was supported by the study of "Effect of Foeniculum vulgare Mill. seed extract on the genital organs of male and female rats" conducted by Dr. Malini T and colleagues.
According to the results, the fennel estrogenic effect in oral administration of acetone extract of Foeniculum vulgare (fennel) seeds for 15 days in male rats, exerted a significant malformation of the male reproductive tract including decreased in testes through inhibited Leydig cell production of testosterone and disrupted fluid reabsorption in the efferent ductules via the ERα and vas deferens in transported sperm from the testicle to the urethra.
Moreover, the application of the extract also demonstrated an increased volume of seminal vesicles and the prostate gland and decreased activities of acid and alkaline phosphatase in all these regions, including bones, intestines, pancreas, and kidneys.
In female rats, ingestion of acetone extract for 10 days showed a strong effect in the expression of estrogenic effect through the observation by vaginal cornification, the test of the appearance of cornified epithelial cells in a vaginal smear for confirmation of the presence of high estrogen levels.
The application also catalyzed the imbalanced production of sex hormones in the female estrus cycle.
At moderate doses, the seeds caused an increase in the weight of mammary glands by overexpression of estrogen circulation precipitated a negative effect in regulated systemic myogenic factors (prolactin, growth hormone) and directed influence of the mammary tissue, such as stromal components and epithelial cells.
At higher doses, fennel seeds increased the weight of the oviduct, endometrium, myometrium, cervix, and vagina.
Taken together, fennel may be considered a functional food for reduced symptoms of estrogen deficiency syndrome and combined with the standard medicine for the treatment of estrogenic-related diseases.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Effect of Foeniculum vulgare Mill. seed extract on the genital organs of male and female rats by Malini T, Vanithakumari G, Megala N, Anusya S, Devi K, Elango V.(PubMed)
(2) Primary dysmenorrhoea: the importance of both prostaglandins E2 and F2 alpha by Lumsden MA, Kelly RW, Baird DT. (PubMed)
(2) Effect of foeniculum vulgare seed extract on mammary glands and oviducts of ovariectomized rats by Devi K1, Vanithakumari G, Anusya S, Mekala N, Malini T, Elango V.(PubMed)
(3) Fennel and anise as estrogenic agents by Albert-Puleo M.(PubMed)
(4) The effect of fennel essential oil on uterine contraction as a model for dysmenorrhea, pharmacology and toxicology study by Ostad SN1, Soodi M, Shariffzadeh M, Khorshidi N, Marzban H.(PubMed)
(5) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
#Herbal #Arctostaphylos uva-ursi Inhibits the Proteins and Pathways Associated with the Risk of #EndometrialCancer, Researchers Say
Kyle J. Norton
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe. The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infections, kidney stones, pelvic pain, etc.
The endometrium is the inner lining of the mammalian uterus and is very susceptible to hormone change, particularly during the menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition in which the cells of the uterus's endometrial lining grow uncontrollably or become cancerous due to the alternation of cells' DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
The Ingredients It contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
Ursolic acid, a pentacyclic triterpene acid, extracted from bearberry is found to be effective in inhibiting the growth of endometrial cancer cell HEC108 line, in a dose- and time-dependent manner. As exposure to Ursolic acid decreased the anti-apoptotic Bcl-2 protein levels (member of the Bcl-2 family of regulator proteins that regulate cell death) but increased Bax expression (upregulated by the tumor suppressor protein p53,) through a mitochondrial pathway, that induced apoptosis of endometrial cancer HEC108 line. Other in the study of the same but within endometrial cancer SNG-II cells, ursolic acid strongly inhibited the growth of SNG-II cells in a dose- and time-dependent manner. The induced apoptotic processes in the endometrial cancer SNG-II cells is also involved mitochondrial pathways and Bcl-2 family proteins.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Herbal Therapy http://kylejnorton.blogspot.ca/p/herbal-therapies.html
References
(1) Molecular mechanism of ursolic acid-induced apoptosis in poorly differentiated endometrial cancer HEC108 cells by Achiwa Y, Hasegawa K, Udagawa Y.(PubMed)
(2) Ursolic acid induces Bax-dependent apoptosis through the caspase-3 pathway in endometrial cancer SNG-II cells by Achiwa Y, Hasegawa K, Komiya T, Udagawa Y.(PubMed)
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe. The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infections, kidney stones, pelvic pain, etc.
The endometrium is the inner lining of the mammalian uterus and is very susceptible to hormone change, particularly during the menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition in which the cells of the uterus's endometrial lining grow uncontrollably or become cancerous due to the alternation of cells' DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
The Ingredients It contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
Ursolic acid, a pentacyclic triterpene acid, extracted from bearberry is found to be effective in inhibiting the growth of endometrial cancer cell HEC108 line, in a dose- and time-dependent manner. As exposure to Ursolic acid decreased the anti-apoptotic Bcl-2 protein levels (member of the Bcl-2 family of regulator proteins that regulate cell death) but increased Bax expression (upregulated by the tumor suppressor protein p53,) through a mitochondrial pathway, that induced apoptosis of endometrial cancer HEC108 line. Other in the study of the same but within endometrial cancer SNG-II cells, ursolic acid strongly inhibited the growth of SNG-II cells in a dose- and time-dependent manner. The induced apoptotic processes in the endometrial cancer SNG-II cells is also involved mitochondrial pathways and Bcl-2 family proteins.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Herbal Therapy http://kylejnorton.blogspot.ca/p/herbal-therapies.html
References
(1) Molecular mechanism of ursolic acid-induced apoptosis in poorly differentiated endometrial cancer HEC108 cells by Achiwa Y, Hasegawa K, Udagawa Y.(PubMed)
(2) Ursolic acid induces Bax-dependent apoptosis through the caspase-3 pathway in endometrial cancer SNG-II cells by Achiwa Y, Hasegawa K, Komiya T, Udagawa Y.(PubMed)
Greentea's Extract Improve inhibits Glucose Uptake through Regulation of Cell Glucose Metabolism, According to Studies
Kyle J. Norton
Green tea may have a therapeutic and positive effect in improved glucose metabolism, some scientists suggested.
The beverage is a precious drink processed with a number of health benefits, known to almost everyone in Asia and the Western world.
Glucose metabolism is an action of the body to convert glucose intake to energy for the needs of body tissue and organs through oxidized glucose to carbon dioxide and water.
Stages of abnormal glucose metabolism stretch from mild forms of glucose intolerance (pre-diabetes), to diabetes and finally to pregravid forms of diabetes associated with the end-organ disease.
Long-term abnormal glucose metabolism is considered a leading cause of diabetes and diabetic complications.
Some researchers even suggested that abnormalities of glucose metabolism can induce excess body weight and increase potentially modifiable risk factors for cardiac morbidity and mortality.
And, long-term impaired glucose tolerance (IGT) is considered as a marker for the state of insulin resistance and prediction of vessel vascular complications, independent of a patient’s progression to diabetes.
Normal blood glucose levels (tested while fasting) of healthy individuals are in the range of 3.9 and 5.5 mmol/L (70 to 100 mg/dL). ...and no more than 7.8 mmol/L (140 mg/dL) 2 hours after eating.
Green tea extract, in the evaluation of the carbohydrate metabolic key enzymes in control and streptozotocin high fat diet-induced diabetic rats in 30 days, demonstrated significant activity in ameliorated overexpression of plasma glucose, glycosylated hemoglobin (HbA1c) and increase in the levels of insulin and hemoglobin.
Expression of hemoglobin A1c is the average level of blood sugar over the past 2 to 3 months.
The typical hemoglobin molecule measured in a volume of blood is 13.8 to 17.2 grams per deciliter (g/dL) for men and 12.1 to 15.1 g/dL for women.
Further analysis also found that the application exerted a profound effect to restore, to some extends, the function of altered activities of the key enzymes of carbohydrate metabolism, such as hexokinase, pyruvate kinase, and lactate dehydrogenase in both diabetic and control groups.
Abnormal (over 10−5M or 0.9 mg%) function of hexokinase in converted glucose into glucose-6-phosphate was associated with moderate to severe hypoglycemia.
Pyruvate Kinase is an enzyme with function in catalyzed the last step of glycolysis.
Deficiency of pyruvate kinase is associated with the risk of metabolic disorders.
Lactate dehydrogenase (LDH or LD) is an enzyme with the function to catalyze the conversion of lactate to pyruvic acid and back.
In the diabetic rats' group, green tea extract strongly averted the abnormal expression of glycogen phosphorylase in the liver to near-normal levels.
Additionally, the diabetic group after administration of green tea extract exhibited antihyperglycemic potential, observed through improved muscle and hepatic glycogen content.
Glycogen phosphorylase is an enzyme with the function to release sugar from cells.
The findings showed that green tea extract has a direct implication in attenuating abnormal glucose metabolism in comparison to the effectiveness of conventional medicine metformin, a standard oral hypoglycemic drug.
Moreover, in the study to confirm the epidemiological studies' suggestion of green tea in the improvement of glucose metabolism in diabetic mice, researchers found that injection of green tea in diabetic mice and streptozotocin-induced diabetic mice after 2-6 h expresses lower levels of glucose with no alternation of serum insulin level, at a dose of 300 mg/kg in compared to normal and control mice.
In protein differentiation, green tea extract administration decreased the serum protein level with function in stimulated glucose production and minimized the increase in blood glucose levels by stimulating additional small amounts of insulin in diabetes.
These results addressed another impact of green tea function in exerting direct influence in the modulation of glucose metabolism in the tested subjects.
Interestingly, in the investigation of green tea's effect on glucose uptake inhibitory activity in Caco-2 cells, scientists also indicated that green tea at a temperature of 60 degrees Celsius significantly improves the capacity of antioxidants in the inhibition of glucose uptake through regulation of cell glucose metabolism.
Incredibly, in temperatures over 60 degrees Celsius, green tea application did not increase or show an upward trend in the inhibitory potential, the Huazhong Agricultural University suggested.
Taken together, green tea with abundant bioactive phytochemicals may be considered as a functional food in improved glucose metabolism in reduced risk of diabetes onset.
People with high-risk diabetes such as prediabetics may want to add 1 or 2 cups of green tea into their daily diet for preventive measures.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet-induced diabetic rats by Sundaram R1, Naresh R, Shanthi P, Sachdanandam P.(PubMed)
(2) Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans by Tsuneki H1, Ishizuka M, Terasawa M, Wu JB, Sasaoka T, Kimura I.(PubMed)
(3) Effect of steeping temperature on antioxidant and inhibitory activities of green tea extracts against α-amylase, α-glucosidase, and intestinal glucose uptake by Liu S1, Ai Z2, Qu F3, Chen Y4, Ni D5. (PubMed)
Green tea may have a therapeutic and positive effect in improved glucose metabolism, some scientists suggested.
The beverage is a precious drink processed with a number of health benefits, known to almost everyone in Asia and the Western world.
Glucose metabolism is an action of the body to convert glucose intake to energy for the needs of body tissue and organs through oxidized glucose to carbon dioxide and water.
Stages of abnormal glucose metabolism stretch from mild forms of glucose intolerance (pre-diabetes), to diabetes and finally to pregravid forms of diabetes associated with the end-organ disease.
Long-term abnormal glucose metabolism is considered a leading cause of diabetes and diabetic complications.
Some researchers even suggested that abnormalities of glucose metabolism can induce excess body weight and increase potentially modifiable risk factors for cardiac morbidity and mortality.
And, long-term impaired glucose tolerance (IGT) is considered as a marker for the state of insulin resistance and prediction of vessel vascular complications, independent of a patient’s progression to diabetes.
Normal blood glucose levels (tested while fasting) of healthy individuals are in the range of 3.9 and 5.5 mmol/L (70 to 100 mg/dL). ...and no more than 7.8 mmol/L (140 mg/dL) 2 hours after eating.
Green tea extract, in the evaluation of the carbohydrate metabolic key enzymes in control and streptozotocin high fat diet-induced diabetic rats in 30 days, demonstrated significant activity in ameliorated overexpression of plasma glucose, glycosylated hemoglobin (HbA1c) and increase in the levels of insulin and hemoglobin.
Expression of hemoglobin A1c is the average level of blood sugar over the past 2 to 3 months.
The typical hemoglobin molecule measured in a volume of blood is 13.8 to 17.2 grams per deciliter (g/dL) for men and 12.1 to 15.1 g/dL for women.
Further analysis also found that the application exerted a profound effect to restore, to some extends, the function of altered activities of the key enzymes of carbohydrate metabolism, such as hexokinase, pyruvate kinase, and lactate dehydrogenase in both diabetic and control groups.
Abnormal (over 10−5M or 0.9 mg%) function of hexokinase in converted glucose into glucose-6-phosphate was associated with moderate to severe hypoglycemia.
Pyruvate Kinase is an enzyme with function in catalyzed the last step of glycolysis.
Deficiency of pyruvate kinase is associated with the risk of metabolic disorders.
Lactate dehydrogenase (LDH or LD) is an enzyme with the function to catalyze the conversion of lactate to pyruvic acid and back.
In the diabetic rats' group, green tea extract strongly averted the abnormal expression of glycogen phosphorylase in the liver to near-normal levels.
Additionally, the diabetic group after administration of green tea extract exhibited antihyperglycemic potential, observed through improved muscle and hepatic glycogen content.
Glycogen phosphorylase is an enzyme with the function to release sugar from cells.
The findings showed that green tea extract has a direct implication in attenuating abnormal glucose metabolism in comparison to the effectiveness of conventional medicine metformin, a standard oral hypoglycemic drug.
Moreover, in the study to confirm the epidemiological studies' suggestion of green tea in the improvement of glucose metabolism in diabetic mice, researchers found that injection of green tea in diabetic mice and streptozotocin-induced diabetic mice after 2-6 h expresses lower levels of glucose with no alternation of serum insulin level, at a dose of 300 mg/kg in compared to normal and control mice.
In protein differentiation, green tea extract administration decreased the serum protein level with function in stimulated glucose production and minimized the increase in blood glucose levels by stimulating additional small amounts of insulin in diabetes.
These results addressed another impact of green tea function in exerting direct influence in the modulation of glucose metabolism in the tested subjects.
Interestingly, in the investigation of green tea's effect on glucose uptake inhibitory activity in Caco-2 cells, scientists also indicated that green tea at a temperature of 60 degrees Celsius significantly improves the capacity of antioxidants in the inhibition of glucose uptake through regulation of cell glucose metabolism.
Incredibly, in temperatures over 60 degrees Celsius, green tea application did not increase or show an upward trend in the inhibitory potential, the Huazhong Agricultural University suggested.
Taken together, green tea with abundant bioactive phytochemicals may be considered as a functional food in improved glucose metabolism in reduced risk of diabetes onset.
People with high-risk diabetes such as prediabetics may want to add 1 or 2 cups of green tea into their daily diet for preventive measures.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet-induced diabetic rats by Sundaram R1, Naresh R, Shanthi P, Sachdanandam P.(PubMed)
(2) Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans by Tsuneki H1, Ishizuka M, Terasawa M, Wu JB, Sasaoka T, Kimura I.(PubMed)
(3) Effect of steeping temperature on antioxidant and inhibitory activities of green tea extracts against α-amylase, α-glucosidase, and intestinal glucose uptake by Liu S1, Ai Z2, Qu F3, Chen Y4, Ni D5. (PubMed)
#Turmeric' s #Curcumin Alleviates the Iron Burden and LiverDysfunction by Reducing NTBI, ALT, and AST Levels in Patients withβ-thalassemia
Kyle J. Norton
Anemia is a health condition in which our body do not have enough red blood cells or less than the normal quantity of hemoglobin in the blood that carries the function of delivering oxygen and nutrient to the tissues.
Patients with Beta-thalassemia minor have a slight lowering of the beta hemoglobin level in the blood similar to those with mild iron-deficiency anemia.
Beta thalassemia can be classified into
* Thalassemia minor, a mild case of anemia. is the most common anemia in people of Mediterranean descent? The blood cells of patients with thalassemia minor are smaller than normal blood cells and easily die off, causing not enough new blood cells to replace the loss of red blood cells.
* Thalassemia major
Thalassemia major also called Cooley's anemia is an inherited disorder that affects the production of normal hemoglobin. Thalassemia major is a deadly disease without frequent blood transfusions, people with this kind of anemia may not survive because of iron building up in the heart and other organs, resulting in heart failure.
The most common symptoms of beta thalassemia are fatigue, weakness, or shortness of breath, a pale appearance or yellow color to the skin (jaundice), irritability, deformities of the facial bone, slow growth, a swollen abdomen, and dark urine.
If you have experienced persistently the aforementioned symptoms, please make sure that you check with your doctor for preventive measures.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In finding a natural treatment for anemia, researchers examined the effects of curcumin, the active polyphenol in turmeric, on iron overload, hepcidin level, and liver function in β-thalassemia major patients.
The double-blind randomized controlled clinical trial was conducted on 68 β-thalassemia major patients, randomly divided into 2 groups to receive either 500 mg curcumin capsules (total: 1,000 mg) twice daily or a placebo for 12 weeks.
Based on the observation of the tested assays, the curcumin group showed a significant decrease in levels of nontransferrin bound iron (NTBI), aminotransferase (ALT) and Aspartate aminotransferase (AST) compared to the placebo group.
In other words, turmeric protects the integrity of the red blood by reducing cellular oxidative stress and inhibiting iron toxicity in β-thalassemia major patients without affecting the levels of hepcidin and other variables.
Based on the results, researchers wrote, " Curcumin administration alleviated the iron burden and liver dysfunction by reducing NTBI, ALT, and AST levels in patients with β-thalassemia major".
Additionally, according to the evaluation of the Mahidol University on 10 β-thalassemia/Hb E patients treated with 500 mg curcuminoids daily for 12 months, injection of the supplement showed significantly decreased intensity in thalassemic plasma, compared to those of normal subjects, including increased levels of plasma levels of proteins associated with the condition and reduced levels of oxidative damage.
More precisely, serum non-transferrin bound iron associated with iron overload, platelet factor-3-like activity, oxidative stress parameters, and antioxidant enzymes were also improved after curcuminoids treatment.
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of β-thalassemia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) An investigation of the effects of curcumin on iron overload, hepcidin level, and liver function in β-thalassemia major patients: A double-blind randomized controlled clinical trial by Mohammadi E1, Tamaddoni A2, Qujeq D3, Nasseri E4, Zayeri F5, Zand H6, Gholami M7, Mir SM. (PubMed)
(2) Role of curcuminoids in ameliorating oxidative modification in β-thalassemia/Hb E plasma proteome by Weeraphan C1, Srisomsap C, Chokchaichamnankit D, Subhasitanont P, Hatairaktham S, Charoensakdi R, Panichkul N, Siritanaratkul N, Fucharoen S, Svasti J, Kalpravidh RW. (PubMed)
Anemia is a health condition in which our body do not have enough red blood cells or less than the normal quantity of hemoglobin in the blood that carries the function of delivering oxygen and nutrient to the tissues.
Patients with Beta-thalassemia minor have a slight lowering of the beta hemoglobin level in the blood similar to those with mild iron-deficiency anemia.
Beta thalassemia can be classified into
* Thalassemia minor, a mild case of anemia. is the most common anemia in people of Mediterranean descent? The blood cells of patients with thalassemia minor are smaller than normal blood cells and easily die off, causing not enough new blood cells to replace the loss of red blood cells.
* Thalassemia major
Thalassemia major also called Cooley's anemia is an inherited disorder that affects the production of normal hemoglobin. Thalassemia major is a deadly disease without frequent blood transfusions, people with this kind of anemia may not survive because of iron building up in the heart and other organs, resulting in heart failure.
The most common symptoms of beta thalassemia are fatigue, weakness, or shortness of breath, a pale appearance or yellow color to the skin (jaundice), irritability, deformities of the facial bone, slow growth, a swollen abdomen, and dark urine.
If you have experienced persistently the aforementioned symptoms, please make sure that you check with your doctor for preventive measures.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In finding a natural treatment for anemia, researchers examined the effects of curcumin, the active polyphenol in turmeric, on iron overload, hepcidin level, and liver function in β-thalassemia major patients.
The double-blind randomized controlled clinical trial was conducted on 68 β-thalassemia major patients, randomly divided into 2 groups to receive either 500 mg curcumin capsules (total: 1,000 mg) twice daily or a placebo for 12 weeks.
Based on the observation of the tested assays, the curcumin group showed a significant decrease in levels of nontransferrin bound iron (NTBI), aminotransferase (ALT) and Aspartate aminotransferase (AST) compared to the placebo group.
In other words, turmeric protects the integrity of the red blood by reducing cellular oxidative stress and inhibiting iron toxicity in β-thalassemia major patients without affecting the levels of hepcidin and other variables.
Based on the results, researchers wrote, " Curcumin administration alleviated the iron burden and liver dysfunction by reducing NTBI, ALT, and AST levels in patients with β-thalassemia major".
Additionally, according to the evaluation of the Mahidol University on 10 β-thalassemia/Hb E patients treated with 500 mg curcuminoids daily for 12 months, injection of the supplement showed significantly decreased intensity in thalassemic plasma, compared to those of normal subjects, including increased levels of plasma levels of proteins associated with the condition and reduced levels of oxidative damage.
More precisely, serum non-transferrin bound iron associated with iron overload, platelet factor-3-like activity, oxidative stress parameters, and antioxidant enzymes were also improved after curcuminoids treatment.
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of β-thalassemia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose and acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) An investigation of the effects of curcumin on iron overload, hepcidin level, and liver function in β-thalassemia major patients: A double-blind randomized controlled clinical trial by Mohammadi E1, Tamaddoni A2, Qujeq D3, Nasseri E4, Zayeri F5, Zand H6, Gholami M7, Mir SM. (PubMed)
(2) Role of curcuminoids in ameliorating oxidative modification in β-thalassemia/Hb E plasma proteome by Weeraphan C1, Srisomsap C, Chokchaichamnankit D, Subhasitanont P, Hatairaktham S, Charoensakdi R, Panichkul N, Siritanaratkul N, Fucharoen S, Svasti J, Kalpravidh RW. (PubMed)
#Trans-Anethole Isolated from Fennel Exerts a Significant Efect in the Inhibited Pro-Inflammatory Mediators Against the Risk of Fever, According to Studies
Kyle J. Norton
Scientists may have found food and plant processes the antipyretic activity comparable to those of acetaminophen in patients with fever, some studies suggested.
Fever is a natural reaction caused by the production of pro-inflammatory cytokines in the immune system in protecting our body from damage and injury against foreign pathogens during the acute phase of infection.
According to medical literature, a person is not considered to have a significant fever until the temperature is above 100.4 F (38.0 C).
Although fever is a common syndrome, however, if you or your kid are experiencing fever accompanied by symptoms of a severe headache, unusual skin rash, sensitivity to bright light, persistent stiff neck and pain, mental confusion, particularly persistent vomiting, and difficulty breathing or chest pain, you or your kid should go to the hospital right the way.
Fennel (Foeniculum vulgare) is a plant species of the genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The plant and food have been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, and relieve PMS,...
In the study to evaluate the antipyretic effect of the aqueous extract of an herbal coded formulation containing an equal amount of Salix alba, Emblica Officinalis, Glycyrrhiza glabra, Adhatoda vasica, Viola odorata, in a yeast-induced pyrexia model in rabbits, researchers found that after recording the results immediately before the administration of the extractor paracetamol and again at 1 hour, application of the extract at 240mg/kg dose significant reduces elevated temperature as compared with that of standard drug paracetamol (150mg/kg).
Fennel extract applied alone showed antipyretic activity against hyperpyrexia in mice, induced by S.C. administration of 2 mL/100 g of a 20% aqueous suspension of brewer's yeast.
As an antipyretic agent, ethanolic extract of F. vulgare fruit showed a moderate antipyretic activity that was statistically significant after 30 and 90 min.
These results showed that herbal coded medicine at a dose of 240mg/kg and fennel extract have marked an antipyretic activity in animal models and this was strongly supported by the ethnopharmacological uses of medicinal plants.
Furthermore, in the examine the hepatotoxicity induced by acetaminophen caused by the excessive production of N-acetyl-para-benzoquinone imine (NAPQI) in the induction of symptoms such as fever due to inflammation, researchers showed that the application of trans-anethole, an aromatic compound isolated from fennel exerted a significant effect in the inhibited pro-inflammatory mediators such as prostaglandin (PGE2), cytokines (TNF, IL-1) and nitric oxide (NO)thus decreasing the risk of fever caused by an overreaction of the immune system.
Application of AN at doses of 125 and 250mg/kg once a day for seven days prevented the changes caused by the APAP overdose.
Additionally, researchers also discovered, that AN infection prevents the overexpression of proinflammatory mediators such as NO, TNF, IL-1α, MIP-1α, and MCP-1 and induced the up-regulation of anti-inflammatory cytokines (IL-4 and IL-10), thus reducing the onset of fever.
Taken all together, there is no doubt that fennel may be considered a functional food for the treatment of inflammatory-induced fever.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Antipyretic potential of herbal coded formulation (Pyrexol) by Khan MS1, Hamid A2, Akram M3, Mustafa SB3, Sami A1, Shah SMA4, Usmanghani K(PubMed)
(3) Acetaminophen-induced hepatotoxicity: Preventive effect of trans-anethole by da Rocha BA1, Ritter AM2, Ames FQ3, Gonçalves OH4, Leimann FV5, Bracht L6, Natali MR7, Cuman RK8, Bersani-Amado CA(PubMed)
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