The #GreenTea's Flavonoids Effects on Anti Inflammatory Bowel Disease (IBD) Through Their Anti-Oxidativestress, Researchers Say

Kyle J. Norton

Green tea may have a therapeutic and positive effect in reducing the risk and treatment of inflammatory bowel disease, some scientists suggested.

Inflammatory bowel disease (IBD) is a condition characterized by inflammation of the large intestine. The disease affects over 1.6 million American today.

The exact causes of inflammatory bowel disease are unknown. As of today, scientists do not know why, people with the same health conditions, are susceptible to the onset of the disease, while others do not.


Some researchers suggested that the disease may be caused by the immune response failing to kill off the invasion of infectious micro-organisms in the acute phase of digestive tissue injury and damage or immune dysfunction mistakenly attacking the digestive tract, a case of autoimmune disease.


Furthermore, prolonged periods of imbalance of the ratio of good and bad bacteria in the colon, long-term intake of certain medicines, age, family history, ethnicity, parasite, unhealthy diet, and smoking are some prevalent risk factors which can lead to the onset of inflammatory bowel disease.


Moreover, if you are living in the Western world, you are also at a higher risk of the onset of the disease.


For example, people who live in Western countries such as the United States and Europe have a higher IBD risk than those in other parts of the world.


Genetic mutations inherited from the parents such as NOD2, ATG16L1and IL23R involved in innate immunity, autophagy, and the inflammatory response may elevate the risk of IBD

The most common symptoms of inflammatory bowel disease are severe diarrhea, abdominal pain, fatigue, and weight loss. If you are experiencing the above symptoms, please make sure that you check with your doctor to rule out the possibility.

Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world.

According to the evaluation of the effect of tea and other sources of flavonoids in reducing inflammatory processes in the development and progression of numerous pathological situations, including inflammatory bowel disease (IBD), the application of the chemical compound exerted a significant effect in the decrease of expression of the reactive oxygen species (ROS) that initiates inflammation and inflammatory process through its antioxidant and free radical scavenging activities.

Furthermore, oral administration of flavonoids also decreased the inflammatory factors in the production of cytokines by inhibiting the synthesis and activities of different pro-inflammatory mediators.

Some researchers suggested the result of flavonoid in reducing inflammation in the intestines may be attributed to the antioxidant activity in inhibition of tumor necrosis factor (TNF, tumor necrosis factor-alpha, TNFα, a cytokine or signaling protein with functions involving systemic inflammation in the response to the acute phase of infection.


The benefits of flavonoids in IDB are also found to associate with the preservation of intestinal function and the ability to interfere simultaneously with every step in the inflammatory process, including the steps in the production of ROS and pro-inflammatory cytokines.

Additional differentiation of the DNA damage induced in vitro in lymphocytes from IBD patients caused by oxidative stress, plant flavonoids, quercetin, and epicatechin found in green tea and other sources such as fruits, tea, and soybeans demonstrated a huge effect in inhibiting oxidative stress caused by the toxic chemical injection.

Compared to the lymphocytes from IBD patients and healthy volunteers, treatment of 50 microg/ml H(2)O(2) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in the presence of quercetin (0-250 microg/ml) or epicatechin (0-100 microg/ml) and flavonoid supplementation (250 microM quercetin or 100 microM epicatechins) displays an impressive inhibition of both oxidative substances in the induction of free radical expression.

Overall, applications of quercetin (0-250 microg/ml) or epicatechin (0-100 microg/ml) demonstrated significant effects in decreasing DNA damage by 48.6% in the group treated with H(2)O(2) and a 43% in IQ group, compared to a healthy group of 35.2 and 57.1%, respectively

However, after taking into account other confounders, researchers indicated that compared to patients with ulcerative colitis (UC) and Crohn's disease (CD), quercetin, IQ and epicatechin reduce DNA damage within lymphocytes from UC patients, compared to CD patients.


Dr. Najafzadeh M, the lead author said, "Flavonoids dramatically reduced oxidative stress in vitro in lymphocytes from IBD patients and healthy individuals. Thus, flavonoids could be very effective in the treatment of oxidative stress and encouraged in the diet of IBD patients".


Taken together, green tea with abundant bioactive flavonoids may be considered a functional food for reducing the prevalence risk factors of IBD and used combined with the standard medicine for the treatment of the disease.

Intake of green supplements should be taken with great care as toxicity was reported in some medical literature.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Flavonoids inhibit the genotoxicity of hydrogen peroxide (H(2)O(2)) and of the food mutagen 2-amino-3-methylimadazo[4,5-f]-quinoline (IQ) in lymphocytes from patients with inflammatory bowel disease (IBD) by Najafzadeh M1, Reynolds PD, Baumgartner A, Anderson D.(PubMed)
(2) Favorable results from the use of herbal and plant products in inflammatory bowel disease: evidence from experimental animal studies by Triantafillidis JK1, Triantafyllidi A1, Vagianos C2, Papalois A3. (PubMed)
(3) Studies in Natural Products Chemistry: Bioactive Natural Products (Part F) by Atta-ur-Rahman

Intake of Nitrate-Rich #BeetrootJuice Daily Improves Vascular Function Against the Risk of #HeartDisease, Researchers Say

Kyle J. Norton


Intake of nitrate-rich beetroot juice may have a substantial and profound effect on improved vascular function, thus reducing the risk of heart disease.

Beet, best known as the beetroot or garden beet is a perennial plant with leafy stems growing to 1–2 m tall, belonging to the amaranth family.

Vascular function is bundled vascular system with function in blood circulation.

Abnormal vascular function is considered one of the risk factors in the development of heart disease.


A total of 69 subjects were recruited in this randomized, double-blind, placebo-controlled parallel study to examine the change in vascular function induced by intake of Nitrate-Rich Beetroot Juice, determined with the use of ultrasound flow-mediated dilatation (FMD).

The flow-mediated dilation (FMD).test, an ultrasound technique performed only by a skilled sonographer is a noninvasive assessment of vascular endothelial function through experts understanding of the physiology, analysis, and interpretation of this measurement

Intake of nitrate-rich beetroot juice displayed a significant increase in the FMD response of 1.1% compared to the placebo group with a decrease of 0.3%


Nitrate-rich beetroot juice group also demonstrated a small improvement in stiffness measured by Aortic Pulse Wave Velocity and showed a trend of continuous improvement compared to placebo.

Aortic Pulse Wave Velocity is a test to measure stiffness of the largest artery in the body, Increased stiffness will result in reduced mobility in related regions.

The result of aortic pulse wave velocity measurement is said to have the ability to identify people in their 20s who are at increased risk for the development of heart disease, stroke, and dementia.


Administration of nitrate-rich beetroot juice showed a strong reduction of 7.6% of platelet-monocyte aggregates compared to an increase of 10.1% in placebo. This finding indicated that nitrate-rich beetroot juice intake had a substantial effect in decreasing the risk of acute myocardial infarction.

Platelet–monocyte aggregates are a novel index with platelet activation and a maker of early onset of acute myocardial infarction.

Furthermore, intake of nitrate-rich beetroot juice group expressed an exceptional improvement of vascular function in reduced P-selectin expression in activated platelet aggression

P-selectin is a cell adhesion molecule (CAM) with the function of mediating the interaction of activated endothelial cells or platelets.


Additionally, the application of the juice also improved the nonpathogenic, commensal bacteria present in the healthy human salivary glands measured by the salivary microbiome compared to a placebo group.

Interestingly, intake of the nitrate-rich beetjuice also responded to the change of 78 bacterial taxa out of thousands harbored in the human gut.

The proportions of Rothia mucilaginosa tended to increase in the nitrate-rich beetroot juice group, in comparison to Neisseria flavescens (P < 0.01) increased in the placebo group.

Rothia mucilaginosa, is considered part of the normal microflora of the human mouth and the upper respiratory tract.

Neisseria flavescens is an uncommon pathogen of human infection, pneumonia, and empyema


There were no adverse effects of dietary nitrate were detected throughout the experiment.

The findings suggested that intake of nitrate-rich beetroot juice daily may have a sustainable effect in improving vascular function, thus reducing the risk of heart disease.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Scienceence, ISSN 0975-6299.


Sources
(1) Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study by Velmurugan S1, Gan JM1, Rathod KS1, Khambata RS1, Ghosh SM1, Hartley A1, Van Eijl S1, Sagi-Kiss V2, Chowdhury TA3, Curtis M4, Kuhnle GG2, Wade WG5, Ahluwalia A6(PubMed)

The Risk of #VulvarCancer Maybe Linearly Associated with the Means of the Levels of Vitamin A in the Body

Kyle J. Norton

Adding a portion of carrots in women daily diet may have a profound and positive effect in reduced risk, progression and treatment of vulvar cancer, some scientists suggested.

The investigations were conducted by a number of respectable universities in women associated to higher risk of vulvar cancers, including the Tampere University Central Hospital and Mercer University and the results were published on online literature.

You can view the detail in the abstracts of the studies by clicking any of the resources link

Vulvar cancer is a medical condition characterized by cell growth irregularly and disorderly in the tissue of the area of skin surrounded the urethra and vagina, including the clitoris and labia.

At the later stage, the cancerous cells may travel a distance away from the original site to infect other healthy tissue.

The results of evaluation were reported by some respectable institutes and published on the online medical literature.

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.

In the study to analyze the association between body mass, selected indicator food intake, and vulvar cancer risk of 125 women aged 80 years or younger with a histologically confirmed diagnosis of invasive vulvar cancer, admitted to a network of general and teaching hospitals in the greater Milan area in compared to Control subjects of 541 patients admitted to teaching and general hospitals in Milan for acute conditions, a researcher found that carrot consumption is associated to reduce risk of cancer.

Compared to others in exerted inconsistent association of risk of vulvar cancer such as milk, meat, liver, alcohol and coffee consumption, carrot demonstrated a significantly decreased risk ratio of 1.4.

The results suggest that certain factors in the dietary and nutritional aspects may process related mechanisms in the risk of vulvar cancer.

Further analysis of carrot effect on the risk of vulvar cancer in regard to the micronutrients expression, researchers found that serum concentrations of vitamin A (retinol), vitamin E (alpha-tocopherol), and total carotene were lower in women with vulvar cancer but no difference to women with other types of female reproductive cancer such as cervical, endometrial and ovarian carcinomas.

Compared to healthy control, the mean levels of vitamin A were significantly less in patients with vulvar cancer.

However, according to the Mercer University, in analysis of the patients with metastasising carcinoma of the uterine cervix or recurrent disease after failure of surgical and/or radiation and chemotherapy therapy.

13-cis-retinoic acid and interferon alpha-2 in the treatment of squamous cell carcinoma of the cervix in 6 patients with locally recurrent or metastasizing squamous cell carcinomas, five of the uterine cervix, and one of the vulva. in the period of 52 days, the median survival time of 107 days, filed the results as follows
* 3 women experienced progression of disease uninfluenced by therapy.
* 1 patient with multiple subcutaneous lymph node metastases showed mixed response for a short period of 3 weeks before progression and eventual death.
* 1 patient had no change or disease for 13 months with subsequent progression and eventual death after 22 months.
* One patient could not be evaluated for an allergic reaction after only 15 days of treatment.

The application also induced adverse effects of "flu-like symptoms", skin irritations, conjunctivitis sicca and chileitis, all WHO 1-2.

Overall toxicity is extremely low compared to standard chemotherapy but is not negligible.

The failure of studies in the treatment of advanced vulvar cancer may be due to a number of implications, researchers at Mercer University suggested, "This might be due to the small number of cases, which is a common problem in immunotherapeutic studies. Moreover, very unfavourable patient selection criteria in our study compared to primarily untreated patients may also have contributed to different response rates. However, in our opinion, the tested regimen cannot be considered sufficiently effective in patients suffering from pretreated, recurrent squamous cell carcinoma of the cervix or vulva".

Taken together, carrots with high amounts of nutrients and antioxidants may be used as a functional food at reduced risk and combined with standard therapy for the treatment of vulvar cancer. However, multi-centers and large sample size studies are necessary to re-confirm this viability.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Selected food intake and risk of vulvar cancer by Parazzini F1, Moroni S, Negri E, La Vecchia C, Dal Pino D, Cavalleri E.(PubMed)
(2) Serum vitamins A and E and carotene in patients with gynecologic cancer by Heinonen PK1, Kuoppala T, Koskinen T, Punnonen R.(PubMed)
(3) [13-cis retinoic acid and interferon-alfa-2a as palliative therapy in pretreated, recurrent squamous epithelial carcinoma of the cervix uteri and vulva] by [Article in German](PubMed)

#Carrot and its Bioactive Compounds Lycopene Reduce the Risk of #GastricCancer Caused by OxidativeStress, DNA Damage, and Helicobacter Pylori Infection, Researchers Say

Kyle J. Norton

Carrots may have a therapeutic and positive effect in reducing risk, progression, and treatment of gastric/stomach cancer, some scientists suggested.

Gastric (Stomach) cancer is a condition characterized by cell growth disorderly and uncontrollably in breast tissue.

At the later stage, the cancerous cells may infect other healthy tissue and organ a distance away from the original site.

The exact causes of gastric cancer are unknown. Researchers do not know why people with the same health conditions and eating habits in the same family, are susceptible to the onset of the disease while others do not.

However, scientists do know that certain risk factors such as Helicobacter pylori infection, smoking family history, mutated genes inherited from the parents, some stomach conditions, and previous stomach surgery are at the elevated risk of gastric cancer.

Moreover, people who have been exposed to ionizing radiation, are smokers with type A blood, and eating lots of processed meats are also at a higher risk of gastric cancer.

The American Cancer Association in the article Can Gastric Cancer Be Prevented? wrote. "A diet high in fresh fruits and vegetables can also lower stomach cancer risk. Citrus fruits (such as oranges, lemons, and grapefruit) may be especially helpful" and ".. eating at least 2½ cups of vegetables and fruits every day. Choosing whole-grain bread, pasta, and cereals instead of refined grains, and eating fish, poultry, or beans instead of processed meat and red meat may also help lower your risk of cancer".

These suggestions strongly agreed that by following a healthy diet and lifestyle with moderate physical activity, the risk of gastric cancers can be reduced substantially and effectively.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.

In the evaluation of carrot intake and risk of gastric cancer, by searching the database of medical
literature from PubMed, Cochrane Library, Scopus, ScienceDirect, and Persian databases like Scientific Information Database (SID) and IranMedx, researchers found that out of 81 articles collected with 5 selected for the study, carrot consumption exerts a reduced gastric cancer risk by 26% with an odds ratio of .74 compared to non-consumers.

Some researchers suggested that lycopene isolated from the carrot and tomatoes may have a substantial inhibitory effect in reducing the risk of gastric cancer caused by oxidative stress, DNA damage, and Helicobacter pylori infection.

Overproduction of ROS, the reactive oxygen species may induce a chain reaction in stimulating more production of free radicals, causing cells and tissues damage and alternated DNA of healthy cells.

Lycopene, a bioactive compound antioxidant found in carrots showed a strong implication on iron metabolism, thus reducing iron-mediated oxidative stress in the induction of cancer cells proliferation and initiation.

Furthermore, the application of lycopene also expressed an inhibition of iron-catalyzed lipid peroxidation by decreasing the malondialdehyde level and enhancing the production of natural antioxidants superoxide dismutase activities in serum and tissues.

These results indicated that the administration of lycopene not only inhibits the overproduction of ROS through its antioxidant activity but also stimulates the expression of natural antioxidants in the host body tissue in preventing DNA damage of healthy cells.
With H. pylori-induced chronic inflammation in facilitating the risk of gastric cancer, researchers at Yonsei University found that injection lycopene exerts a significant effect in inhibiting the increase of ROS, apoptosis, and alterations in the cell-cycle distribution in human gastric carcinoma AGS cells.

The results of the above differentiation were supported by the study from the period 1997-1999 with 120 incident and histologically verified cases of stomach cancer, matched on age, sex, residence, and urban/rural status and 360 controls conducted by the Jiangsu Cancer Hospital and Research Institute.


According to the study, vitamin A, alpha-carotene, and lycopene found in carrots and tomatoes were associated with strongly inverse relationships with stomach cancer with alpha-carotene scoring the highest odds ratio of .34.

The joint exposure to high intakes of alpha-carotene and vitamin C was associated with an even higher reduction of gastric cancer risk with an odds ratio of only 0.11.

The findings strongly suggested that long-term intake of carrots in moderate amounts may have substantial implications in the prevention and treatment of gastric cancer. But Intake of carrot supplements should be taken with care to prevent acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of Carrot Intake in the Prevention of Gastric Cancer: A Meta-Analysis by Fallahzadeh H1, Jalali A2, Momayyezi M1, Bazm S3(PubMed)
(2) Dietary carotenoids and risk of gastric cancer: a case-control study in Uruguay by De Stefani E1, Boffetta P, Brennan P, Deneo-Pellegrini H, Carzoglio JC, Ronco A, Mendilaharsu M.(PubMed)
(3) Anticancer Effect of Lycopene in Gastric Carcinogenesis by Mi Jung Kim and Hyeyoung Kim(PMC)
(4) Protective effects of lycopene on oxidative stress, proliferation, and autophagy in iron supplementation rats by Liu C1, Wang R, Zhang B, Hu C, Zhang H.(PubMed)
(5) Lycopene inhibits Helicobacter pylori-induced ATM/ATR-dependent DNA damage response in gastric epithelial AGS cells by Jang SH1, Lim JW1, Morio T2, Kim H3. (PubMed)

#Fennel Processes Anti #Anxiolytic Property Similar to those #Diazepam with No Adverse Effects, Scientists Find

Kyle J. Norton

Fennel may have a therapeutic effect in reducing risk and treatment of anxiety, some scientists suggested.
Anxiety is a psychological problem caused by significant feelings of anxiety and fear of present and future events.

In conventional medicine, an anxiolytic also known as an antianxiety agent including buspirone (BuSpar), trazodone, venlafaxine, and several of the benzodiazepines, is a medication used to reduce physical and psychological symptoms of anxiety disorder.

Anxiety is caused by a combination of several factors. However, stress directly from all sources is considered a major cause of the disease.

Other causes of anxiety include the longterm use of illicit drugs, medication intake, and medical conditions and diseases associated with reduced lung functioning

Although the medicine may be effective, however, short and long-term use can cause symptoms of nausea. nervousness, dizziness, reduced sexual desire, insomnia.

In severe cases, the medicine can also cause blurred vision. confusion, nightmare, and difficulty thinking or remembering.

If you are taking the above medicine, please make sure that you understand all the side effects.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...

In the investigate of the anxiolytic activity of ethanolic extracts of Foeniculum vulgare fruit by elevated plus maze, rotarod, open field test, and hole board models, researchers found that application of fennel extracts in the does of100-200mg/kg exerts a significant anti-anxiolytic activity, similar to those of standard anxiolytic drugs diazepam (1mg/kg) without inducing intolerable adverse effects.

This result was observed by the increased number of entries and time spent in the open arm in the elevated plus maze apparatus.

And, application the same doses also promoted a number of rearings, assisted rearing and number of square crossed viewed by an open field test.

Further analysis also discovered that of fennel extracts also processes a potent skeletal muscle relaxant effect assessed by rotarod.

Additionally, in the experiment of the elevated plus maze, rotarod, open field, and hole board used in the evaluation of the psychomotor performance and emotional aspects of rodents removed from their acclimatized cage and placed in an environment express anxiety and fear, the application of fennel extract, researchers indicated that
* Fennel injection group decreases anxiety-related behavior to an open area.

* Treated rodents exhibit a significant increase in the number of open arm entries and rearings, time spent in the center and line crossing and head dipping.

* Fennel extract treated group also reduces numbers of time of falling through increased muscle relaxant and improved locomotor function.

These results not only are given the supports to the holistic use of fennel in the treatment of anxiety but also reconfirmed the efficacy of fennel extract in reducing levels of anxiety in tested rodents whose were placed in the environment with an expression of anxiety and fear in the first study.

Truly, the viability of above is also reaffirmed by the study conducted by the Geethanjali College of pharmacy in adult Swiss albino male mice randomly divided into six groups (n = 6).

According to the results of analysis of groups I and II received Tween 80 (5%, v/v) and diazepam (0.5 mg/kg, ip), groups III to VI received orally 50, 100, and 200 and 400 mg/kg doses of the essential oil of F. vulgare, mice groups treated with 50, 100, and 200 and 400 mg/kg displayed a significant reduction of anxiety score through expression of all tests, including elevated plus maze (EPM), staircase test (SCT) and open field test (OFT) and other various parameters in doses dependent manner.

Compared to a higher dose of 400 mg/kg and lower dose treatment group, application of 100 and 200 mg/kg dose of fennel essential oil mice demonstrated a strong decrease of anxiety through increased percent number of entries and time spent in open arms.

Compared to other doses of treatment group, administration of 200 mg/kg dose significantly increased the number of squares crossed at the center in the OFT test.

Furthermore, although the injection of 100 and 200 mg/kg doses of the essential oil-treated mice showed a significant reduction of rearing compared to another group, only the 200 mg/kg dose of the oil expressed statistically significant reduction in rearing compared with diazepam, the conventional medicine used for the treatment of anxiety.

The discovery in the study postulated that fennel essential oil may have a potential effect in reducing anxiety nonlinearly and doses dependently.

"Fennel extract may possess anxiolytic activity supporting its traditional claim about anxiolytic activity", reported in the 19th edition of Pharmacology and Pharmacotherapeutics by Sathodkar, Bhandarkar, and Rege.

Taken together, there is no doubt that fennel extracts and essential oil may be considered a secondary therapeutic treatment compared to standard medicine in the treatment of anxiety.

However, intake of fennel supplement should be taken with extreme care in the prevention of toxicity.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) EVALUATION OF ANXIOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF FOENICULUM VULGARE IN MICE MODEL Research Article R. NAGA KISHORE by Cheeryal (V), Keesara (M), N. ANJANEYULU, M. NAGA GANESH AND N. SRAVYA(International (Journal of Pharmacy and Pharmaceutical Sciences)
(2) Evaluation of the anxiolytic activity of the essential oil of the aerial part of Foeniculum vulgare Miller in mice by Miraf Mesfin, Kaleab Asres, and Workineh Shibeshi(PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)

#Healthyfood #Catnip Improves #PenileErection and #MaleSexualDesire, Researchers Suggest

Kyle J. Norton

Herbal catnip process a high amount of dopamine and may be considered a functional herb used to prevent and treat penile erection and increase male sexual desire, some scientists suggested.

Dopamine, a neurotransmitter plays an important role in the brain of the human body, including sexual behavior.

Besides in regulation of cognitive, integrative, and reward processes, the organic chemical of catecholamine and phenethylamine also can trigger penile erection and control of sexual function by acting on oxytocinergic neurons.

Erectile dysfunction (ED) or impotence is a condition of a male who can not get or maintain an erection firm enough to have sexual intercourse.

Most cases of erectile dysfunction (ED) are associated with medical conditions such as heart disease, diabetes, and obesity. However, according to the statistics, the incidence also is associated with
the psychological problems in some men.

Some researchers suggested that certain risk factors such as increased age, stress, anxiety, drug abuse, excessive alcohol drinking, smoking, and particularly in people with the long-term use of certain medications such as diuretics and beta-blockers can facilitate the early onset of the conditions.

Sexual desire is a motivational state and an interest in “sexual objects or activities, or as a wish, or drive to seek out sexual objects or to engage in sexual activities, according to the definition provided by the study of SEX DIFFERENCES AND SIMILARITIES IN FREQUENCY AND INTENSITY OF SEXUAL DESIRE conducted by Dr. Regan, Pamela C.;and Dr. Atkins, Leah

According to the self-reported frequency and intensity of sexual desire among an ethnically diverse sample of 676 men and women, the doctors found that men are experiencing a higher overall level of sexual desire than did women. and in the sex differences with respect to the frequency of sexual desire, Men also are experiencing sexual desire more often than did women.

Catnip is also known as Catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia.

The common herb has been used in herbal medicine as an insect repellent and to treat digestive disorders, children's restlessness and nervousness, fevers, colds and flu, skin irritations that stimulate sweating, promote menstruation, etc.

In the study to evaluate the effect of Nepeta cataria (NC), catnip on sexual behavior, and penile erection researchers at the Paulista University, launched an investigation with male rats acutely fed chow enriched with 10% NC leaves.

All tested rats are randomly divided into 2 groups, the NC group is received for a 4h period the chow is enriched with 10% NC leaves while the control groups received regular chow.


Researchers found that compared to control groups, NS fed group demonstrated an apomorphine-induced penile erection and motor coordination observed by the general activity in the open field that was assessed 0, 15, 30, and 60 min after treatment.

Dr. Bernardi MM, the lead scientist after considering all co and confounders said, "NC treatment increased male rat's penile erection. Slight facilitation in male rat sexual behavior and a decrease in general activity of NC-treated rats were observed. No effects on motor coordination and yawning episodes were detected by the NC treatment".

The findings suggested that NC application may increase penile erection and improve male rat sexual behavior by action on dopaminergic systems.

In fact, the effect of a pro-erectile dose of apomorphine, a mixed dopamine receptor agonist, also showed stimulation of dopamine receptors, inducing the release of oxytocin in the brain to mediate and reinforcing effects of sexual activity in regulating the sexual behavior (e.g., penile erection) with those controlling sexual motivation and sexual arousal.

Physically, dopamine can trigger penile erection by acting on oxytocinergic neurons located in the paraventricular nucleus of the hypothalamus and perhaps on the pro-erectile sacral parasympathetic nucleus within the spinal cord.

Dr. Baskerville TA said," Dopamine demonstrates the potential existence of an interaction between central dopamine and hormone in controlling sexual reproduction during penile erection.

Several studies suggested that dopamine is a neurotransmitter that processes the potency in regulating and controlling penile erection and sexual behavior, but the use of herbal medicine should only be prescribed by herbalists to prevent depression.

Taken together, Herbal catnip may be considered a functional herb to improve erectile dysfunction and sexual desire, without inducing side effects compared to conventional medicine such as Avanafil (Stendra) Sildenafil (Viagra) Tadalafil (Cialis) Vardenafil (Levitra, Staxyn).


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Nepeta cataria L. var. citriodora (Becker) increases penile erection in rats by Bernardi MM1, Kirsten TB, Lago JH, Giovani TM, Massoco Cde O.(PubMed)
(2) Dopamine and male sexual function by Giuliano F1, Allard J.(PubMed)
(3) Dopamine-oxytocin interactions in penile erection by Baskerville TA1, Allard J, Wayman C, Douglas AJ. (PubMed)
(4) SEX DIFFERENCES AND SIMILARITIES IN FREQUENCY AND INTENSITY OF SEXUAL DESIRE by Dr. Regan, Pamela C, and Dr. Atkins, Leah

#Garlic and Its Lipid-Based Extracts Inhibits the Risk of #BowelCancer through Cell Cycle Arrest and Induced Apoptosis, Researcher Find

Kyle J. Norton

Studies suggested that garlic may have the potential in killing bowel cancer cells before it can spread to form colonization.
Bowel cancer also known as colorectal cancer, is a chronic medical condition caused by the abnormal proliferation of cells in the colon, rectum, or vermiform appendix.

Bowel cancer is a relatively very common and slowly growing cancer. The progression of cancer is predictable.

The exact causes of bowel cancer are unknown. researchers as of today do not know why people in the same health condition and age in the same family and similar dietary patterns, are susceptible to the onset of bowel cancer, while others do not.

However, researchers do know that certain risk factors are associated with the development of the disease, including age, family history

Some researchers suggested that the mutated gene is inherited from the parents, and certain medical conditions such as inflammatory bowel disease, polyps, and obesity are also some of the bowel cancer prevalent risk factors.

A recent study also showed people who smoke and consume high volumes of red meat are also at an elevated risk of the onset of the disease.

Truly, following a healthy diet and active lifestyle can decrease the risk of bowel cancer by 10 folds. Dr. IAIN ROBERTSON, the lead author at Monash University, in the study "Colorectal cancer, diet, and lifestyle factors: opportunities for prevention" wrote, " The potential for colorectal cancer risk reduction by decreasing consumption of animal fats, red meat, alcohol, and cigarettes, by increasing physical activity levels, and by increasing intake of fruits, vegetables, and dietary fiber".

If you are experiencing symptoms of a change of bowel habits that last longer than one month, persistent rectal bleeding, abdominal pain that does not stop,.and blood in the stool, please check with your doctor to rule out the possibility of bowel cancer.

Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia.

The pungent spice has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.

Allicin (diallyl thiosulfinate), is the best-known biologically active component in freshly crushed garlic, found to reduce the risk of bowel cancer through inhibiting bowel cancer cell lines HCT-116, LS174T, HT-29, and Caco-2, via the activity of Nrf2, according to The Hebrew University of Jerusalem.

Nrf2 is a protein that regulates the expression of antioxidant proteins to protect the cells against damage and injury caused by oxidative stress triggered by inflammation.

However, in the colon cancer cell lines, overexpression of Nsf2 can initiate cancer cell apoptosis.

The Chungbuk National University study that uses colon cancer cells (SW620 and HCT116) to investigate whether sulfur compounds thiacremonone isolated from garlic could modulate NF-kappaB activity and thereby induce apoptotic cell death of colon cancer cells, suggested, the application of different concentrations ranging from 30 - 150 microg/ml of thiacremonone for the periods from 0 to 48 hour inhibited colon cancer cell (SW620 and HCT116) growth followed by induction of apoptosis in a dose-dependent manner.

Further analysis showed that the efficacy of the novel sulfur compound against colon cancer cell growth and induction of apoptotic cell death was attributed to the compound's function in modulating NF-kappaB, a protein that controls transcription of DNA, cytokine production, and cell survival.

In vitro, intake of garlic and its lipid-based extracts, induced cell cycle arrest, through a fourfold increase in caspase activity (apoptosis) in PC-3 cells when treated at a dose of 0.5 or 1 μg/m and may be considered a potential as promising anticancer agents, including colon cancer.

Dr. Baena R and Dr, Salinas P said, " Dietary factors and lifestyle may contribute to the increasing colorectal cancer (CRC) incidence... Fish consumption may decrease CRC risk by 12% whereas garlic intake is not significantly associated with reduced CRC risk".

In fact, diet represents 30-35% of risk factors that contribute to the onset of cancer, adding garlic to your diet together with the reduction of meat intake can reduce the risk of various cancers, including colorectal cancer

However, in order to confirm garlic isolated compounds' anti-bowel cancer efficacy, further data collection on large example size and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2 by Bat-Chen W1, Golan T, Peri I, Ludmer Z, Schwartz B.(PubMed)
(2) Inhibition of cell growth and induction of apoptosis via inactivation of NF-kappaB by a sulfur compound isolated from garlic in human colon cancer cells by Ban JO1, Yuk DY, Woo KS, Kim TM, Lee US, Jeong HS, Kim DJ, Chung YB, Hwang BY, Oh KW, Hong JT. (PubMed)
(3) Crude Garlic Extract Inhibits Cell Proliferation and Induces Cell Cycle Arrest and Apoptosis of Cancer Cells In Vitro by Bagul M1, Kakumanu S1, Wilson TA1,2. (PubMed)
(4) Diet and colorectal cancer by Baena R1, Salinas P2(PubMed)
(5) Diet and cancer: risk factors and epidemiological evidence by Baena Ruiz R1, Salinas Hernández P2.(PubMed)
(6) Colorectal cancer, diet and lifestyle factors: opportunities for prevention by IAIN ROBERTSON, RONA BOUND and LEONIE SEGAL, (Monash University)