Kyle J. Norton
Scientists may have found a bioactive compound in the prevention and treatment of allergies with no side effects, according to studies.
Piperine is a phytochemical alkaloid in the class of organosulfur compounds, found abundantly in white and black pepper, long pepper, etc.
Allergies are the result of the abnormally immune systematic response to typically harmless substances in the environment, leading to the symptoms and reaction in the nose, lungs, throat, sinuses, ears, lining of the stomach, or on the skin.
Believe it or not, the diseases associated with the hyperactivity of the immune system include hay fever, food allergies, atopic dermatitis, allergic asthma, and anaphylaxis.
According to the Centers for Disease Control and Prevention (CDC), Over 20 million Americans 18 and older and more than 6.1 million children were diagnosed with allergic rhinitis, commonly known as hay fever, in 2015. Another 20 million Americans were diagnosed with respiratory, food, or skin allergies.
In the comparison of the allergic effect in school today and in the past, it often feels like food allergies are far more common today than in their youth, the incidence rarely happened in the past school days.
What contributes to the hyperactivity of the immune system in triggering food allergy today compared to the past. No one knows.
However, researchers do know that certain risk factors including children, adults younger than 18 years old, family history of allergy, and having asthma, particularly in people with a genetic preposition are associated with the onset of allergy.
Dr. Romina A. Ortiz, the lead scientist in the immunity team at the Johns Hopkins Asthma & Allergy Center, said, " Genome-wide association studies (GWAS) has been widely employed in the field of allergic disease, and to date, significant associations have been published for nearly 100 asthma genes/loci, in addition to multiple genes/loci for AD, AR and IgE levels".
And, " Molecular genetics has undergone a technological revolution, leading to next-generation sequencing (NGS) strategies that are increasingly employed to hone in on the causal variants associated with allergic diseases".
These results clearly indicated that people who inherited the mutated gene from the parent that causes over-reactivity of the immune system are at an increased risk of allergy
In finding a natural constituent or wholefood for the prevention and treatment of allergy with no side effects, researchers at Kinki University investigated the anti-allergy effect of the extract of the Piper nigrum leaf.
The extracts at a different doses of 50, 200, and 500 mg/kg exerted a significant activity in inhibiting the cutaneous reaction at the early phase and later phase in dinitrofluorobenzene (DNFB) induced allergic mice.
The allergic effect of ear swelling also was inhibited by the PN-ext (50, 200, and 500 mg/kg, per os (p.o.)). But this effect on very late phase response (vLPR) in the model mice was significant but weaker than that on IPR.
At day 7, administration of PN-ext (50, 200, and 500 mg/kg for 7 d) completely inhibited picryl chloride (PC)-induced ear swelling in PC-sensitized mice.
The results were attributed to the extract inhibitory effect on compound 48/80-induced histamine release from rat peritoneal mast cells.
The in-depth analysis of the result suggested that 2 Two lignans of PN-ext, (-)-cubebin (1) and (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (2), from the piperine found in the extract, were identified as major active principles having histamine release-inhibitory activity.
In additional evaluation of the piperine antiallergic effect, researchers launched a study of Balb/c mice to test the effect of piperine on airway hyperresponsiveness, pulmonary eosinophilic infiltration, and various immune cell phenotypes.
The Balb/c mice were induced asthma by ovalbumin sensitization and inhalation. Piperine (4.5 and 2.25 mg/kg) was orally administered 5 times a week for 8 weeks.
Piperine-treated groups showed a strongly suppressed eosinophil infiltration, allergic airway inflammation, and airway hyperresponsiveness by inhibiting the proinflammatory cytokines and levels of immunoglobulin E and histamine.
In other words, the therapeutic mechanism by which piperine effectively treats asthma is based on a reduction of Th2 cytokines associated with the promotion of IgE and eosinophilic responses.
Taken altogether, piperine, a major bioactive compound found in black pepper may be used for the prevention and treatment of allergy caused by immune overreaction.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Histamine release inhibitory activity of Piper nigrum leaf by Hirata N, Naruto S, Inaba K, Itoh K, Tokunaga M, Iinuma M, Matsuda H.(PubMed)
(2) Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model by Kim SH, Lee YC. (PubMed)
(3) Genetics of Allergic Diseases by Romina A. Ortiz, MS, and Kathleen C. Barnes, Ph.D. (PubMed)
Tuesday, 4 July 2023
Vitamins Exert A strong Effect on the Over Growth of #CandidaAlbicans, According to Studies
Kyle J. Norton
Candida albicans are members of a large group of microorganisms whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to a joint study, in many cases, biofilm(microorganisms with cells sticking to each other on a surface) formation(7) gene mutations(8), and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.
NADPH oxidase (NOX) are enzymes that generate reactive oxygen species by transporting electrons across lipid membranes. to induce cytotoxicity against invading microbes. However, according to the joint study led by Johns Hopkins University Bloomberg School of Public Health, Candida albicans is capable of a ROS burst, using a member of the NOX enzyme family to produce ROS with an aim to drive fungal morphogenesis in the animal host(a).
Vitamin A, B2, C, and E as antioxidants and free radical scavengers may have a potential role in inhibited superoxide anion (ROS) radicals caused by overexpression of candida via NADPH oxidase (NOX) enzymes(b).
.
The Anti Over Growth of Candida Vitamins
1. Vitamin B2
Vitamin B2 required for a wide variety of cellular processes plays a key role in energy metabolism and enhances the digestive system in absorbing nutrients and supports the immune system(230)(231) in fighting against bacteria causes of inflammatory disease, including candida(232).
2. Vitamin C
Vitamin C, a water-soluble vitamin and an antioxidant found in high concentrations in immune cells is not only important in aiding the digestive system in absorbing nutrients but also enhances the production of white blood cells (233)(234) of the immune system(235) in protection of the body by binding to the harmful bacteria(236) and ingesting them.
3. Vitamin A
Retinoic acid appears to maintain normal skin health by switching on genes and differentiating keratinocytes (immature skin cells)(237) into mature epidermal cells and helps to detox the liver(238).
The vitamin also enhances the immune system(239)(240) in protecting our body through its antimicrobial functions, including Candida albicans(241).
4. Vitamin E
Vitamin E is a fat-soluble compound that included both tocopherols and tocotrienols. It not only is a polyphenol antioxidant (242)(246) in scavenging free radicals and microorganisms but also promotes the immune system is enhanced functions of B-cells(244)(245), the immune cells(245)(247) in the production of antibodies to destroy infectious agents.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(a) Candida albicans FRE8 encodes a member of the NADPH oxidase family that produces a burst of ROS during fungal morphogenesis by Rossi DCP1, Gleason JE1, Sanchez H2, Schatzman SS1, Culbertson EM1, Johnson CJ2, McNees CA1, Coelho C3, Nett JE2, Andes DR2, Cormack BP4, Culotta VC(PubMed)
(b) Free radical scavenging and antiproliferative properties of Biginelli adducts by da Silva DL1, Reis FS, Muniz DR, Ruiz AL, de Carvalho JE, Sabino AA, Modolo LV, de Fátima A(PubMed)
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(230) Edible mushrooms: improving human health and promoting quality life by Valverde ME1, Hernández-Pérez T1, Paredes-López O1.(PubMed)
(231) [Effect of some vitamins on activity of immunocompetent cells].[Article in Russian]by Nezgovorov DV.(PubMed)
(232) Antioxidants keep the potentially probiotic but highly oxygen-sensitive human gut bacterium Faecalibacterium prausnitzii alive at ambient air by Khan MT1, van Dijl JM1, Harmsen HJ1.(PubMed)
(233) Storing red blood cells with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions: a metabolomics overview by Pallotta V1, Gevi F1, D'alessandro A1, Zolla L1.(PubMed)
(234) Red blood cell metabolism under prolonged anaerobic storage by D'Alessandro A1, Gevi F, Zolla L.(PubMed)
(235) Alterations in antioxidant defense system of workers chronically exposed to arsenic, cadmium and mercury from coal flying ash by Zeneli L1, Sekovanić A, Ajvazi M, Kurti L, Daci N.(PubMed)(236) Indomethacin-induced translocation of bacteria across enteric epithelia is reactive oxygen species-dependent and reduced by vitamin C by Schoultz I1, McKay CM, Graepel R, Phan VC, Wang A, Söderholm J, McKay DM.(PubMed)
(237) Vitamin C derivative ascorbyl palmitate promotes ultraviolet-B-induced lipid peroxidation and cytotoxicity in keratinocytes by Meves A1, Stock SN, Beyerle A, Pittelkow MR, Peus D.(PubMed)
238. Effects of dried fish on antioxidant levels in rat liver by Anilakumar KR1, Khanum F, Krishna KR, Viswanathan KR.(PubMed)
(239) Vitamin A and retinoic acid in T cell-related immunity by Ross AC1.(PubMed)
(240) Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance by Cassani B1, Villablanca EJ, De Calisto J, Wang S, Mora JR.(PubMed)(241) Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes by Klassert TE1, Hanisch A, Bräuer J, Klaile E, Heyl KA, Mansour MK, Tam JM, Vyas JM, Slevogt H.(PubMed)
(242) [Toxicology of the synthetic antioxidants BHA and BHT in comparison with the natural antioxidant vitamin E].[Article in German]by Kahl R1, Kappus H.(PubMed)
(243) Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants by Darr D1, Dunston S, Faust H, Pinnell S.(PubMed)
(244) Immune dysfunction and cytokine production in hemodialysis. Could they be lessened by vitamin E-coated dialyzer membrane by Senatore M, Cecere P, Colombo P, Costantini L, Filiberti O, Piccini G, Peona C, Buemi M, Nicoletti A, Rizzuto G.(PubMed)
(245) Prospective crossover trial of the influence of vitamin E-coated dialyzer membranes on T-cell activation and cytokine induction by Girndt M1, Lengler S, Kaul H, Sester U, Sester M, Köhler H.(PubMed)
(246) Vitamin E and immunity by Moriguchi S1, Muraga M.(PubMed)
(247) The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging.by Moriguchi S1.(PubMed)(249) By the way, doctor. I recently saw a TV ad for a product called "coralcalcium," which is supposed to prevent osteoporosis and other diseases. What do you know about it by Robb-Nicholson C.(PubMed)
Candida albicans are members of a large group of microorganisms whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to a joint study, in many cases, biofilm(microorganisms with cells sticking to each other on a surface) formation(7) gene mutations(8), and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.
NADPH oxidase (NOX) are enzymes that generate reactive oxygen species by transporting electrons across lipid membranes. to induce cytotoxicity against invading microbes. However, according to the joint study led by Johns Hopkins University Bloomberg School of Public Health, Candida albicans is capable of a ROS burst, using a member of the NOX enzyme family to produce ROS with an aim to drive fungal morphogenesis in the animal host(a).
Vitamin A, B2, C, and E as antioxidants and free radical scavengers may have a potential role in inhibited superoxide anion (ROS) radicals caused by overexpression of candida via NADPH oxidase (NOX) enzymes(b).
.
The Anti Over Growth of Candida Vitamins
1. Vitamin B2
Vitamin B2 required for a wide variety of cellular processes plays a key role in energy metabolism and enhances the digestive system in absorbing nutrients and supports the immune system(230)(231) in fighting against bacteria causes of inflammatory disease, including candida(232).
2. Vitamin C
Vitamin C, a water-soluble vitamin and an antioxidant found in high concentrations in immune cells is not only important in aiding the digestive system in absorbing nutrients but also enhances the production of white blood cells (233)(234) of the immune system(235) in protection of the body by binding to the harmful bacteria(236) and ingesting them.
3. Vitamin A
Retinoic acid appears to maintain normal skin health by switching on genes and differentiating keratinocytes (immature skin cells)(237) into mature epidermal cells and helps to detox the liver(238).
The vitamin also enhances the immune system(239)(240) in protecting our body through its antimicrobial functions, including Candida albicans(241).
4. Vitamin E
Vitamin E is a fat-soluble compound that included both tocopherols and tocotrienols. It not only is a polyphenol antioxidant (242)(246) in scavenging free radicals and microorganisms but also promotes the immune system is enhanced functions of B-cells(244)(245), the immune cells(245)(247) in the production of antibodies to destroy infectious agents.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(a) Candida albicans FRE8 encodes a member of the NADPH oxidase family that produces a burst of ROS during fungal morphogenesis by Rossi DCP1, Gleason JE1, Sanchez H2, Schatzman SS1, Culbertson EM1, Johnson CJ2, McNees CA1, Coelho C3, Nett JE2, Andes DR2, Cormack BP4, Culotta VC(PubMed)
(b) Free radical scavenging and antiproliferative properties of Biginelli adducts by da Silva DL1, Reis FS, Muniz DR, Ruiz AL, de Carvalho JE, Sabino AA, Modolo LV, de Fátima A(PubMed)
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeastspecies. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in yeast Candida by Prasad R1, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(230) Edible mushrooms: improving human health and promoting quality life by Valverde ME1, Hernández-Pérez T1, Paredes-López O1.(PubMed)
(231) [Effect of some vitamins on activity of immunocompetent cells].[Article in Russian]by Nezgovorov DV.(PubMed)
(232) Antioxidants keep the potentially probiotic but highly oxygen-sensitive human gut bacterium Faecalibacterium prausnitzii alive at ambient air by Khan MT1, van Dijl JM1, Harmsen HJ1.(PubMed)
(233) Storing red blood cells with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions: a metabolomics overview by Pallotta V1, Gevi F1, D'alessandro A1, Zolla L1.(PubMed)
(234) Red blood cell metabolism under prolonged anaerobic storage by D'Alessandro A1, Gevi F, Zolla L.(PubMed)
(235) Alterations in antioxidant defense system of workers chronically exposed to arsenic, cadmium and mercury from coal flying ash by Zeneli L1, Sekovanić A, Ajvazi M, Kurti L, Daci N.(PubMed)(236) Indomethacin-induced translocation of bacteria across enteric epithelia is reactive oxygen species-dependent and reduced by vitamin C by Schoultz I1, McKay CM, Graepel R, Phan VC, Wang A, Söderholm J, McKay DM.(PubMed)
(237) Vitamin C derivative ascorbyl palmitate promotes ultraviolet-B-induced lipid peroxidation and cytotoxicity in keratinocytes by Meves A1, Stock SN, Beyerle A, Pittelkow MR, Peus D.(PubMed)
238. Effects of dried fish on antioxidant levels in rat liver by Anilakumar KR1, Khanum F, Krishna KR, Viswanathan KR.(PubMed)
(239) Vitamin A and retinoic acid in T cell-related immunity by Ross AC1.(PubMed)
(240) Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance by Cassani B1, Villablanca EJ, De Calisto J, Wang S, Mora JR.(PubMed)(241) Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes by Klassert TE1, Hanisch A, Bräuer J, Klaile E, Heyl KA, Mansour MK, Tam JM, Vyas JM, Slevogt H.(PubMed)
(242) [Toxicology of the synthetic antioxidants BHA and BHT in comparison with the natural antioxidant vitamin E].[Article in German]by Kahl R1, Kappus H.(PubMed)
(243) Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants by Darr D1, Dunston S, Faust H, Pinnell S.(PubMed)
(244) Immune dysfunction and cytokine production in hemodialysis. Could they be lessened by vitamin E-coated dialyzer membrane by Senatore M, Cecere P, Colombo P, Costantini L, Filiberti O, Piccini G, Peona C, Buemi M, Nicoletti A, Rizzuto G.(PubMed)
(245) Prospective crossover trial of the influence of vitamin E-coated dialyzer membranes on T-cell activation and cytokine induction by Girndt M1, Lengler S, Kaul H, Sester U, Sester M, Köhler H.(PubMed)
(246) Vitamin E and immunity by Moriguchi S1, Muraga M.(PubMed)
(247) The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging.by Moriguchi S1.(PubMed)(249) By the way, doctor. I recently saw a TV ad for a product called "coralcalcium," which is supposed to prevent osteoporosis and other diseases. What do you know about it by Robb-Nicholson C.(PubMed)
#Fennel Exerts a Significant Reduction of the Intensity and Weakness, Duration of the Menstrual Period in #PrimaryDysmenorrhea Patients
Kyle J. Norton
Adding a portion of fennel to the daily diet may have a potential and positive effect in reduced pain caused by sensory neuron stimulus in women with primary dysmenorrhea, some scientists suggested.
The results of the investigation were carried out by a number of respectable institutes, including the Babol University of Medical Sciences and Health Services, and details of the experiment were published in the online medical library.
Antinociceptive activity is an action or process of blocking the painful injurious stimulus by sensory neurons.
Dysmenorrhea is also known as a painful period, a menstrual cramp in the regions of the pelvis or lower abdomen that last a few days during menstruation, caused by the overproduction of certain hormones in the family of prostaglandins.
Some women may experience periodic pains during or prior to, or after menstrual periods in the lower abdomen. In some cases, the pain can also spread over to the whole abdomen and lumbosacral region.
There are 2 Types of dysmenorrhea
* Primary dysmenorrhea
Primary dysmenorrhea affects about 90% of girls in the first 2 years of menstruation. Some researchers suggested that it may be caused by the immature of reproductive organs.
* Secondary dysmenorrhea
Secondary dysmenorrhea is caused by gynecological diseases. including hormone imbalance, endometriosis, fibromas, pelvic inflammatory disease, etc.
Accompanied by the painful period, women may also experience psychological symptoms such as anxiety, depression, irritability, digestive symptoms such as nausea, vomiting, and physical symptoms such as headaches, dizziness, and painful breasts.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In order to compare the effect of combination of fennel extract/vitamin E with ibuprofen on the intensity of pain in primary dysmenorrhea among the students of Tabriz city in 2007-2009, researchers od the joint study led by the Kosar Department of Shahid Motahhary Hospital carried out an investigation of 68 students from Medical and Tabriz universities, who were living in the dormitory, suffering from primary dysmenorrhea.
All participants were randomly divided into two groups of 34 students each (the two groups used combination of fennel extract/vitamin E and ibuprofen cross-over form in the 2 months).
Application of the combination displayed a mean of peak pain intensity in the first, second, third, sixth, and forty-eighth hours that is significantly lower than the ibuprofen group.
Also, a combination of fennel extract/vitamin E was more effective than ibuprofen in the first hour (P < 0.03) and second hour (P < 0.04), according to the Visual Analogue Scale (VAS) tool for ranking the intensity of the pain.
These results suggested that the fennel and vitamin E combination was more efficacy in blocking the neuron in transmitting pain caused by overexpression prostaglandins hormone in the induction of abdominal muscle constriction compared to conventional medicine ibuprofen.
Dr. Nasehi M, the lead author, after taking into account of other co and confounders said, "Combination of fennel extract/vitamin E is effective on decreasing the intensity of pain of primary dysmenorrhea, and it is advised to those who cannot use chemical drugs".
In a separate study to investigate the effect of fennel used alone on primary dysmenorrhea symptoms and amenorrheal duration, 80 female students satisfied the criteria and guideline were randomly divided into two groups of intervention (n = 40) and control (n = 40).
The intervention group was given one soft capsule Fennel (30 mg) every 4 hours, 3 days before menstruation till the 5th day, and continued for 3 months. The control group received no medication.
According to the result of the experiments, fennel treated group exerted a significant decrease of the mean nausea intensity and weakness from 1.93, and 2.88 after 3 months, in comparison to a control group from 2.37, and 6.65 in the control group.
Furthermore, compared to the control group, the fennel group reduced the duration of the menstrual period after two and three months of use.
Moreover, Fennel treated group demonstrated a strong improvement in quality and feelings of well-being after 1 and 3 months.
Taken together, fennel may be considered a functional food for the treatment of Primary Dysmenorrhea without inducing adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effect of fennel on pain quality, symptoms, and menstrual duration in primary dysmenorrhea by Ghodsi Z1, Asltoghiri M2. (PubMed)
(2) Comparison of the effectiveness of combination of fennel extract/vitamin E with ibuprofen on the pain intensity in students with primary dysmenorrhea by Nasehi M1, Sehhatie F2, Zamanzadeh V3, Delazar A4, Javadzadeh Y5, Chongheralu BM6.(PubMed)
Adding a portion of fennel to the daily diet may have a potential and positive effect in reduced pain caused by sensory neuron stimulus in women with primary dysmenorrhea, some scientists suggested.
The results of the investigation were carried out by a number of respectable institutes, including the Babol University of Medical Sciences and Health Services, and details of the experiment were published in the online medical library.
Antinociceptive activity is an action or process of blocking the painful injurious stimulus by sensory neurons.
Dysmenorrhea is also known as a painful period, a menstrual cramp in the regions of the pelvis or lower abdomen that last a few days during menstruation, caused by the overproduction of certain hormones in the family of prostaglandins.
Some women may experience periodic pains during or prior to, or after menstrual periods in the lower abdomen. In some cases, the pain can also spread over to the whole abdomen and lumbosacral region.
There are 2 Types of dysmenorrhea
* Primary dysmenorrhea
Primary dysmenorrhea affects about 90% of girls in the first 2 years of menstruation. Some researchers suggested that it may be caused by the immature of reproductive organs.
* Secondary dysmenorrhea
Secondary dysmenorrhea is caused by gynecological diseases. including hormone imbalance, endometriosis, fibromas, pelvic inflammatory disease, etc.
Accompanied by the painful period, women may also experience psychological symptoms such as anxiety, depression, irritability, digestive symptoms such as nausea, vomiting, and physical symptoms such as headaches, dizziness, and painful breasts.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In order to compare the effect of combination of fennel extract/vitamin E with ibuprofen on the intensity of pain in primary dysmenorrhea among the students of Tabriz city in 2007-2009, researchers od the joint study led by the Kosar Department of Shahid Motahhary Hospital carried out an investigation of 68 students from Medical and Tabriz universities, who were living in the dormitory, suffering from primary dysmenorrhea.
All participants were randomly divided into two groups of 34 students each (the two groups used combination of fennel extract/vitamin E and ibuprofen cross-over form in the 2 months).
Application of the combination displayed a mean of peak pain intensity in the first, second, third, sixth, and forty-eighth hours that is significantly lower than the ibuprofen group.
Also, a combination of fennel extract/vitamin E was more effective than ibuprofen in the first hour (P < 0.03) and second hour (P < 0.04), according to the Visual Analogue Scale (VAS) tool for ranking the intensity of the pain.
These results suggested that the fennel and vitamin E combination was more efficacy in blocking the neuron in transmitting pain caused by overexpression prostaglandins hormone in the induction of abdominal muscle constriction compared to conventional medicine ibuprofen.
Dr. Nasehi M, the lead author, after taking into account of other co and confounders said, "Combination of fennel extract/vitamin E is effective on decreasing the intensity of pain of primary dysmenorrhea, and it is advised to those who cannot use chemical drugs".
In a separate study to investigate the effect of fennel used alone on primary dysmenorrhea symptoms and amenorrheal duration, 80 female students satisfied the criteria and guideline were randomly divided into two groups of intervention (n = 40) and control (n = 40).
The intervention group was given one soft capsule Fennel (30 mg) every 4 hours, 3 days before menstruation till the 5th day, and continued for 3 months. The control group received no medication.
According to the result of the experiments, fennel treated group exerted a significant decrease of the mean nausea intensity and weakness from 1.93, and 2.88 after 3 months, in comparison to a control group from 2.37, and 6.65 in the control group.
Furthermore, compared to the control group, the fennel group reduced the duration of the menstrual period after two and three months of use.
Moreover, Fennel treated group demonstrated a strong improvement in quality and feelings of well-being after 1 and 3 months.
Taken together, fennel may be considered a functional food for the treatment of Primary Dysmenorrhea without inducing adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effect of fennel on pain quality, symptoms, and menstrual duration in primary dysmenorrhea by Ghodsi Z1, Asltoghiri M2. (PubMed)
(2) Comparison of the effectiveness of combination of fennel extract/vitamin E with ibuprofen on the pain intensity in students with primary dysmenorrhea by Nasehi M1, Sehhatie F2, Zamanzadeh V3, Delazar A4, Javadzadeh Y5, Chongheralu BM6.(PubMed)
#Galectin-9 (Gal-9), a #Phytochemical #Lectins Inhibits #KidneyCancer by Binding to the Cancer Cell Remembrances or. and Receptors to Induce Cytotoxicity
Kyle J. Norton
Lentils' (plant sources') lectin may be considered biomarkers for the detection of the early stage of various types of cancer and the treatment of renal cancer, some scientists suggested.
Lentil, a type of pulse and tiny legume that can be cooked quickly and rich in protein and fiber is a bushy annual plant of genus Lens to the Fabaceae family, native to the Middle East.
Kidney Cancer is a medical condition characterized by irregular cell growth in the tissue of the kidneys.
At the later stage, the cancerous cells may travel a distance way to infect other organs' tissues.
For example, if kidney cancer spread to the lung is called kidney cancer with lung metastases.
At the very early stage of the kidney, cancerous tumors are localized in the surface of the kidneys.
The most common type of kidney cancer is renal cell cancer.
The kidney is of 3 main detoxified organs with the main function of filtering water and waste from your blood.
The causes of kidney cancer are unknown, but some researchers suggested that genetic mutation, cigarette smoking, obesity, family history,..... and exposure to chemicals, such as asbestos and benzene are all associated with increased risk of kidney cancer.
The cancer is only infected approximately 2% of the general population and screening test is only designated for kidney cancer in people who are at higher risk of the disease.
In the UK, The survival rate of early diagnosis of the early stage of kidney cancer is very high with five-year survival rates for renal cancer of 70-94% for localized tumors
According to statistics reported by Dr. Lewis G, the lead author, " Kidney cancers account for 2-3% of all adult malignancies in the UK. Men are predominantly affected by renal cancer with an average age at diagnosis of 64 years. Renal (or clear) cell carcinoma (RCC) accounts for 90% of kidney cancers"(4) and "RCC should be suspected in the presence of localized symptoms such as flank pain, a loin mass or haematuria; constitutional upset including weight loss, pyrexia and/or night sweats; or with unexplained laboratory tests"(4).
Imaging tests such as computed tomography (CT) or magnetic resonance imaging (MRI), are the best to spot cancer in patients who are at high risk and susceptible to kidney cancer.
According to the investigation of plant lectin's effect on the risk of cancers, by resisting digestion, lectins after intake maintained full biological activity in binding to the cancer cell remembrances or. and receptors to induce cytotoxicity, thus reducing cancer cell proliferation and inhibiting tumor growth.
lectins can also incorporate into cancer cells as an antigen to cause agglutination and/or aggregation in the induction of cytolysis and inhibit the expression of polyamines, small organic cations that are essential for cancer cells to grow.
Furthermore, plant lectins altered the production of various interleukins that are of essential importance for the function of both innate and adaptive immunity by activating certain protein kinases in regulating signal transduction pathways in the control of cancer cell process in the induction of tumor progression.
Additionally, lectins can also bind to cancer cell mutated ribosomes, a cell structure that makes protein and inhibits protein synthesis, thus disrupting the critical cellular processes necessary for sustained cancer cell growth and modifying the cancer cell phase 1 division and G2/M phase cell cycle arrest.
Interestingly, the injection of lectins also inhibited telomerase expression in cancer cell activity in maintaining tumor progression and angiogenesis in the stimulated production of the new blood vessel to provide nutrients and oxygen to cancer cells' proliferation and tumor expansion.
In clear-cell renal cell carcinoma (ccRCC), Galectin-9 (Gal-9), an animal lectin injection exerted a significant effect in inhibiting cancer cell proliferation through binding to β-galactoside which is important to provide energy to tumor survival.
Further investigation of the expression of Gal-9 in a total of 196 patients with ccRCC who underwent nephrectomy, with 48/196 patients died and 61/196 patients suffering recurrence to assess the prognostic value of Gal-9, suggested that Gal-9 expression not only associates positively with tumor size but also induces a direct impact in the relative survival ratio, used to predict overall survival (OS) and recurrence-free survival (RFS) of patients.
Indeed, high levels of Gal-9 were found to associate correlated with poor survival and early recurrence and the expression of lectin also can be considered as a biomarker in diagnosed clear-cell renal cell carcinoma (ccRCC) in early stage and lower grade tumor, node, and metastasis in patients who are at higher risk of the kidney cancer developing.
The finding evidence suggested that lectins from all sources may be considered therapeutic substances and biomarkers for treatment and monitoring the progression of kidney cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lectin reactivity of alpha-fetoprotein in a case of renal cell carcinoma by Taketa K1, Ichikawa E, Sakuda H, Iwamasa T, Hayakawa M, Taga H, Hirai H.(PubMed)
(2) Lectins as bioactive plant proteins: a potential in cancer treatment by De Mejía EG1, Prisecaru VI.(PubMed)
(3) Galectin-9 predicts postoperative recurrence and survival of patients with clear-cell renal cell carcinoma by Fu H1, Liu Y, Xu L, Liu W, Fu Q, Liu H, Zhang W, Xu J.(PubMed)
(4) Early diagnosis improves survival in kidney cancer by Lewis G1, Maxwell AP(PubMed)
Lentils' (plant sources') lectin may be considered biomarkers for the detection of the early stage of various types of cancer and the treatment of renal cancer, some scientists suggested.
Lentil, a type of pulse and tiny legume that can be cooked quickly and rich in protein and fiber is a bushy annual plant of genus Lens to the Fabaceae family, native to the Middle East.
Kidney Cancer is a medical condition characterized by irregular cell growth in the tissue of the kidneys.
At the later stage, the cancerous cells may travel a distance way to infect other organs' tissues.
For example, if kidney cancer spread to the lung is called kidney cancer with lung metastases.
At the very early stage of the kidney, cancerous tumors are localized in the surface of the kidneys.
The most common type of kidney cancer is renal cell cancer.
The kidney is of 3 main detoxified organs with the main function of filtering water and waste from your blood.
The causes of kidney cancer are unknown, but some researchers suggested that genetic mutation, cigarette smoking, obesity, family history,..... and exposure to chemicals, such as asbestos and benzene are all associated with increased risk of kidney cancer.
The cancer is only infected approximately 2% of the general population and screening test is only designated for kidney cancer in people who are at higher risk of the disease.
In the UK, The survival rate of early diagnosis of the early stage of kidney cancer is very high with five-year survival rates for renal cancer of 70-94% for localized tumors
According to statistics reported by Dr. Lewis G, the lead author, " Kidney cancers account for 2-3% of all adult malignancies in the UK. Men are predominantly affected by renal cancer with an average age at diagnosis of 64 years. Renal (or clear) cell carcinoma (RCC) accounts for 90% of kidney cancers"(4) and "RCC should be suspected in the presence of localized symptoms such as flank pain, a loin mass or haematuria; constitutional upset including weight loss, pyrexia and/or night sweats; or with unexplained laboratory tests"(4).
Imaging tests such as computed tomography (CT) or magnetic resonance imaging (MRI), are the best to spot cancer in patients who are at high risk and susceptible to kidney cancer.
According to the investigation of plant lectin's effect on the risk of cancers, by resisting digestion, lectins after intake maintained full biological activity in binding to the cancer cell remembrances or. and receptors to induce cytotoxicity, thus reducing cancer cell proliferation and inhibiting tumor growth.
lectins can also incorporate into cancer cells as an antigen to cause agglutination and/or aggregation in the induction of cytolysis and inhibit the expression of polyamines, small organic cations that are essential for cancer cells to grow.
Furthermore, plant lectins altered the production of various interleukins that are of essential importance for the function of both innate and adaptive immunity by activating certain protein kinases in regulating signal transduction pathways in the control of cancer cell process in the induction of tumor progression.
Additionally, lectins can also bind to cancer cell mutated ribosomes, a cell structure that makes protein and inhibits protein synthesis, thus disrupting the critical cellular processes necessary for sustained cancer cell growth and modifying the cancer cell phase 1 division and G2/M phase cell cycle arrest.
Interestingly, the injection of lectins also inhibited telomerase expression in cancer cell activity in maintaining tumor progression and angiogenesis in the stimulated production of the new blood vessel to provide nutrients and oxygen to cancer cells' proliferation and tumor expansion.
In clear-cell renal cell carcinoma (ccRCC), Galectin-9 (Gal-9), an animal lectin injection exerted a significant effect in inhibiting cancer cell proliferation through binding to β-galactoside which is important to provide energy to tumor survival.
Further investigation of the expression of Gal-9 in a total of 196 patients with ccRCC who underwent nephrectomy, with 48/196 patients died and 61/196 patients suffering recurrence to assess the prognostic value of Gal-9, suggested that Gal-9 expression not only associates positively with tumor size but also induces a direct impact in the relative survival ratio, used to predict overall survival (OS) and recurrence-free survival (RFS) of patients.
Indeed, high levels of Gal-9 were found to associate correlated with poor survival and early recurrence and the expression of lectin also can be considered as a biomarker in diagnosed clear-cell renal cell carcinoma (ccRCC) in early stage and lower grade tumor, node, and metastasis in patients who are at higher risk of the kidney cancer developing.
The finding evidence suggested that lectins from all sources may be considered therapeutic substances and biomarkers for treatment and monitoring the progression of kidney cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lectin reactivity of alpha-fetoprotein in a case of renal cell carcinoma by Taketa K1, Ichikawa E, Sakuda H, Iwamasa T, Hayakawa M, Taga H, Hirai H.(PubMed)
(2) Lectins as bioactive plant proteins: a potential in cancer treatment by De Mejía EG1, Prisecaru VI.(PubMed)
(3) Galectin-9 predicts postoperative recurrence and survival of patients with clear-cell renal cell carcinoma by Fu H1, Liu Y, Xu L, Liu W, Fu Q, Liu H, Zhang W, Xu J.(PubMed)
(4) Early diagnosis improves survival in kidney cancer by Lewis G1, Maxwell AP(PubMed)
#Healthyfood #Eggplant Phenolic Compounds Inhibits OxidativeStress Inducing #ChronicDiseases, Scientists Suggest
Kyle J. Norton
Scientists may have found a whole fruit or vegetable with the potential to treat cardiovascular disease with no side effects, some studies found.
Cardiovascular disease is a class of conditions associated with heart and blood vessels. Anything that affects the normal heart and blood vessel functioning is considered a risk factor for the disease, including the heart's muscles, valves, or rhythm, and blockage of blood vessels.
According to the statistics, in the US, approximately, 610,000 people die of heart disease every year that's 1 in every 4 deaths. The disease is the leading cause of death for both men and women.
The causes of cardiovascular diseases are associated with the location that affects the functioning of the heart and blood vessels, including atherosclerosis is caused by the blockade of the blood vessel due to the accumulation of plaques in the arteries and arrhythmias caused by abnormal heart rhythms.
Epidemiological studies strongly suggested that the most common cardiovascular disease that affects most heart disease patients is coronary artery disease (CAD).
Coronary artery disease (CAD) is the most common form of heart disease caused by one or more of the coronary arteries becoming narrow or blocked.
Some researchers suggested that the widespread diagnosis of coronary artery disease (CAD) in the Western world probably is a result of the promotion of the Western diet over the last few decades.
A diet high in bad cholesterol, salts, and sugar, and carcinogens associated with the accumulation of plaques on the arteries has been found to be a culprit of the onset of coronary artery disease in many studies.
Dr. Oikonomou E, the lead author in the joint study led by the National and Kapodistrian University of Athens on the concerns of CAD widespread in the Western world launched an investigation to examine the independent predictive value of an unhealthy diet on the severity of coronary artery disease (CAD).
In the total of 188 symptomatic stable patients with CAD. Patients were categorized as having severe CAD or nonsevere CAD by coronary angiography.
Among several demographics and clinical characteristics, all patients were tested using a semiquantitative food frequency questionnaire.
By analyzing the 8 principal components in the 8 distinct dietary patterns found in the returned questionnaire, researchers found that The Western dietary pattern (increased intake of fat, red meat, and carbohydrates and minimal consumption of fruits and green leafy vegetables) was predictive of severe CAD (area under the curve: 0.73, 95% confidence intervals: 0.64-0.83, P < .001).
These results not only suggested that the Western not only causes the onset of the disease but also increased the risk of severity of coronary artery lesions in patients with stable CAD.
The doctors in the study wrote the final report, "The findings highlight the role of dietary patterns when estimating cardiovascular risk for the management of patients with CAD".
Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India.
The plant has been cultivated in southern and eastern Asia since prehistory. It is famous for its deep purple and the best eggplant can be found from August through October when it is in season.
The chemical constituents of eggplant include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids, and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin, and other Polyphenolic compounds.
In the finding, a natural compound with the efficacy for the prevention and treatment of cardiovascular disease with no side effects, researchers at the University of Connecticut School of Medicine examine the role of raw and grilled eggplants on cardioprotection using an isolated perfusion heart model.
The animals were fed freeze-dried products of either raw or grilled eggplants for 30 days. After 30 days, isolated working hearts were subjected to 30 min ischemia followed by 2 h of reperfusion.
The medical assays suggested eggplants process potent cardioprotective compounds judging by their ability to increase left ventricular function and reduce myocardial infarct size and cardiomyocyte apoptosis.
Interestingly, researchers found no difference in cardioprotective ability between raw and grilled products.
Based on the antioxidant vitamins classification, researchers showed that vitamin A, vitamin C, and β-carotene, were lower and some of the polyphenolic components, especially nasunin content, were higher in grilled eggplants, These results indicated that there must be some other ingredient processed by both grill and raw eggplants that exert cardiovascular diseases not found in this study.
Moreover, in the study to analyze total phenolics and antioxidant capacity in the indigenous vegetables for cardioprotective effect researchers at the Tuskegee University conducted a group analysis including collard greens, mustard greens, kale, okra, green onion, butter beans, butter peas, purple hull peas, rutabagas, and eggplant.
At a concentration of 10.0 mg dried vegetable equivalent/ml, the extract of these vegetables exerted a significant antioxidant activity by reducing 13.2-88.5% DPPH(•) radical in 30 min.
The Oxygen Radical Absorbance Capacity. (ORAC) value ranged from 2.5 to 100.7 µmoles of Trolox equivalents per gram of dried sample.
The antioxidant capacity of the vegetable samples was highly related to their total phenolic content.
The evidence suggested these indigenous vegetables are good sources of phenolic compounds, which might provide anti-oxidative protection against free radicals in inducing chronic diseases, such as cardiovascular disease.
Taken together, eggplant processed abundantly bioactive antioxidants may be considered a functional vegetable for the prevention and an adjunct therapy combined with the primary medicine for the treatment of cardiovascular disease without inducing any adverse effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cardioprotective properties of raw and cooked eggplant (Solanum melongena L) by Das S1, Raychaudhuri U, Falchi M, Bertelli A, Braga PC, Das DK. (PubMed)
(2) Total phenolics and antioxidant capacity of indigenous vegetables in the southeast United States: Alabama Collaboration for CardiovascularEquality Project by Huang Z1, Wang B, Eaves DH, Shikany JM, Pace RD. (PubMed)
(3) Western Dietary Pattern Is Associated With Severe Coronary Artery Disease by Oikonomou E1, Psaltopoulou T2, Georgiopoulos G1, Siasos G1,3, Kokkou E1, Antonopoulos A1, Vogiatzi G1, Tsalamandris S1, Gennimata V1, Papanikolaou A1, Tousoulis D. (PubMed)
Scientists may have found a whole fruit or vegetable with the potential to treat cardiovascular disease with no side effects, some studies found.
Cardiovascular disease is a class of conditions associated with heart and blood vessels. Anything that affects the normal heart and blood vessel functioning is considered a risk factor for the disease, including the heart's muscles, valves, or rhythm, and blockage of blood vessels.
According to the statistics, in the US, approximately, 610,000 people die of heart disease every year that's 1 in every 4 deaths. The disease is the leading cause of death for both men and women.
The causes of cardiovascular diseases are associated with the location that affects the functioning of the heart and blood vessels, including atherosclerosis is caused by the blockade of the blood vessel due to the accumulation of plaques in the arteries and arrhythmias caused by abnormal heart rhythms.
Epidemiological studies strongly suggested that the most common cardiovascular disease that affects most heart disease patients is coronary artery disease (CAD).
Coronary artery disease (CAD) is the most common form of heart disease caused by one or more of the coronary arteries becoming narrow or blocked.
Some researchers suggested that the widespread diagnosis of coronary artery disease (CAD) in the Western world probably is a result of the promotion of the Western diet over the last few decades.
A diet high in bad cholesterol, salts, and sugar, and carcinogens associated with the accumulation of plaques on the arteries has been found to be a culprit of the onset of coronary artery disease in many studies.
Dr. Oikonomou E, the lead author in the joint study led by the National and Kapodistrian University of Athens on the concerns of CAD widespread in the Western world launched an investigation to examine the independent predictive value of an unhealthy diet on the severity of coronary artery disease (CAD).
In the total of 188 symptomatic stable patients with CAD. Patients were categorized as having severe CAD or nonsevere CAD by coronary angiography.
Among several demographics and clinical characteristics, all patients were tested using a semiquantitative food frequency questionnaire.
By analyzing the 8 principal components in the 8 distinct dietary patterns found in the returned questionnaire, researchers found that The Western dietary pattern (increased intake of fat, red meat, and carbohydrates and minimal consumption of fruits and green leafy vegetables) was predictive of severe CAD (area under the curve: 0.73, 95% confidence intervals: 0.64-0.83, P < .001).
These results not only suggested that the Western not only causes the onset of the disease but also increased the risk of severity of coronary artery lesions in patients with stable CAD.
The doctors in the study wrote the final report, "The findings highlight the role of dietary patterns when estimating cardiovascular risk for the management of patients with CAD".
Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India.
The plant has been cultivated in southern and eastern Asia since prehistory. It is famous for its deep purple and the best eggplant can be found from August through October when it is in season.
The chemical constituents of eggplant include sterols (i.e. typical plant sterols, androstane, pregnane and cholestane derivatives, steroidal alkaloids, and sapogenins), phytosterols, triterpenes, δ-amyrin, Chlorogenic acid, Nasunin, and other Polyphenolic compounds.
In the finding, a natural compound with the efficacy for the prevention and treatment of cardiovascular disease with no side effects, researchers at the University of Connecticut School of Medicine examine the role of raw and grilled eggplants on cardioprotection using an isolated perfusion heart model.
The animals were fed freeze-dried products of either raw or grilled eggplants for 30 days. After 30 days, isolated working hearts were subjected to 30 min ischemia followed by 2 h of reperfusion.
The medical assays suggested eggplants process potent cardioprotective compounds judging by their ability to increase left ventricular function and reduce myocardial infarct size and cardiomyocyte apoptosis.
Interestingly, researchers found no difference in cardioprotective ability between raw and grilled products.
Based on the antioxidant vitamins classification, researchers showed that vitamin A, vitamin C, and β-carotene, were lower and some of the polyphenolic components, especially nasunin content, were higher in grilled eggplants, These results indicated that there must be some other ingredient processed by both grill and raw eggplants that exert cardiovascular diseases not found in this study.
Moreover, in the study to analyze total phenolics and antioxidant capacity in the indigenous vegetables for cardioprotective effect researchers at the Tuskegee University conducted a group analysis including collard greens, mustard greens, kale, okra, green onion, butter beans, butter peas, purple hull peas, rutabagas, and eggplant.
At a concentration of 10.0 mg dried vegetable equivalent/ml, the extract of these vegetables exerted a significant antioxidant activity by reducing 13.2-88.5% DPPH(•) radical in 30 min.
The Oxygen Radical Absorbance Capacity. (ORAC) value ranged from 2.5 to 100.7 µmoles of Trolox equivalents per gram of dried sample.
The antioxidant capacity of the vegetable samples was highly related to their total phenolic content.
The evidence suggested these indigenous vegetables are good sources of phenolic compounds, which might provide anti-oxidative protection against free radicals in inducing chronic diseases, such as cardiovascular disease.
Taken together, eggplant processed abundantly bioactive antioxidants may be considered a functional vegetable for the prevention and an adjunct therapy combined with the primary medicine for the treatment of cardiovascular disease without inducing any adverse effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cardioprotective properties of raw and cooked eggplant (Solanum melongena L) by Das S1, Raychaudhuri U, Falchi M, Bertelli A, Braga PC, Das DK. (PubMed)
(2) Total phenolics and antioxidant capacity of indigenous vegetables in the southeast United States: Alabama Collaboration for CardiovascularEquality Project by Huang Z1, Wang B, Eaves DH, Shikany JM, Pace RD. (PubMed)
(3) Western Dietary Pattern Is Associated With Severe Coronary Artery Disease by Oikonomou E1, Psaltopoulou T2, Georgiopoulos G1, Siasos G1,3, Kokkou E1, Antonopoulos A1, Vogiatzi G1, Tsalamandris S1, Gennimata V1, Papanikolaou A1, Tousoulis D. (PubMed)
#Phytochemical #Sulforaphane Increases the Levels of Antioxidant Against Oxidative Damage Triggered by Injury and Inflammatio, According to Studies
Kyle J. Norton
Scientists may have found a natural ingredient for the prevention and treatment of liver disease with no side effects, according to studies.
Liver disease in most cases is linked to alcohol or drugs. In fact, it can be caused by a variety of factors and affects everyone from infants to older adults, including infected viruses such as hepatitis A, B, C, and medication overloaded.
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
The most common symptoms of liver disease include weakness and fatigue, weight loss, nausea, vomiting, and jaundice.
If you are experiencing some of the above symptoms, please make sure you check with your doctor to rule out the possibility of liver disease.
According to the statistic provided by the Canadian Liver Foundation, approximately, one in 10 Canadians, or more than three million people, have some form of liver disease and over a period of only eight years, the death rate from liver disease has risen nearly 30%.
These incidences of liver disease not only lead to dismissing the quality of life and life expectancy but cause a financial burden on the health care system.
Conventional treatment of liver disease depends on your diagnosis. Most cases of liver disease can be treated with lifestyle modifications, such as stopping alcohol use in alcoholic fatty liver disease or losing weight, in nonalcoholic liver disease.
Dr. Valerio Nobili, the lead scientist in the examined the role of lifestyle changes in the management of chronic liver disease, said, "Several liver conditions which are directly affected by overweight and obese status, including non-alcoholic fatty liver disease, chronic infection with hepatitis C virus and post-liver transplant status".
And, "The deleterious effects of obesity on liver disease and overall health can be significantly impacted by a culture that fosters sustained nutritional improvement and regular physical activity".
With an aim to find a natural ingredient for the treatment of liver disease, researchers evaluated the ability of sulforaphane, an activator of Nrf2, to blunt CYP2E1-dependent, ethanol-induced steatosis in vivo and in vitro.
Where Nuclear factor (erythroid-derived 2)-like 2, (Nrf2), is a pro-antioxidant protein that plays a critical role in protecting our body against oxidative damage triggered by injury and inflammation.
And CYP2E1 is a protein involved in the metabolism of xenobiotics in the body.
The application of sulforaphane (SFN) treatment increased the levels of antioxidants by activating the levels of the Nrf2 and lowering oxidant stress observed by the decline in lipid peroxidation and increase in glutathione (GSH) levels.
SFN also decreased liver levels of triglycerides and cholesterol elevated by the injection of ethanol.
The results strongly suggested that SFN inhibited liver disease by increasing the expression of antioxidant enzymes and lowing the expression of free radicals as well as reducing the liver fat deposits.
Moreover, in the investigation to determine whether glucoraphanin and its breakdown product sulforaphane, are potent modulators of various phase I and phase II enzymes involved in carcinogen-metabolizing enzyme systems in vitro, researchers showed that injection of glucoraphanin at higher concentrations (25 μM) decreased dealkylation of methoxyresorufin, a marker for cytochrome P4501 activity
Where cytochrome P4501 is an enzyme involved in the metabolism of endogenous substrates and drugs, as well as the activation of certain toxins and environmental pollutants.
Compared to glucoraphanin, sulforaphane is superior to its precursor in modulating carcinogen-metabolizing enzyme systems in vitro.
The University of Rhode Island, Kingston study also suggested that SF activates Nrf2 activation in inhibited lipid accumulation in white adipose tissue, suppressed adipogenesis, insulin resistance, glucose intolerance, and hepatic steatosis in Lep(ob/ob) mice.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis by Zhou R1, Lin J, Wu D.(PubMed)
(2) Sulforaphane is superior to glucoraphanin in modulating carcinogen-metabolizing enzymes in Hep G2 cells by Abdul Razis AF1, Noor NM. (PubMed)
(3) Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice by Xu J1, Kulkarni SR, Donepudi AC, More VR, Slitt AL. (PubMed)
(4) The role of lifestyle changes in the management of chronic liver disease by Valerio Nobili, Christine Carter-Kent,2, and Ariel E Feldstein. (PMC)
Scientists may have found a natural ingredient for the prevention and treatment of liver disease with no side effects, according to studies.
Liver disease in most cases is linked to alcohol or drugs. In fact, it can be caused by a variety of factors and affects everyone from infants to older adults, including infected viruses such as hepatitis A, B, C, and medication overloaded.
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
The most common symptoms of liver disease include weakness and fatigue, weight loss, nausea, vomiting, and jaundice.
If you are experiencing some of the above symptoms, please make sure you check with your doctor to rule out the possibility of liver disease.
According to the statistic provided by the Canadian Liver Foundation, approximately, one in 10 Canadians, or more than three million people, have some form of liver disease and over a period of only eight years, the death rate from liver disease has risen nearly 30%.
These incidences of liver disease not only lead to dismissing the quality of life and life expectancy but cause a financial burden on the health care system.
Conventional treatment of liver disease depends on your diagnosis. Most cases of liver disease can be treated with lifestyle modifications, such as stopping alcohol use in alcoholic fatty liver disease or losing weight, in nonalcoholic liver disease.
Dr. Valerio Nobili, the lead scientist in the examined the role of lifestyle changes in the management of chronic liver disease, said, "Several liver conditions which are directly affected by overweight and obese status, including non-alcoholic fatty liver disease, chronic infection with hepatitis C virus and post-liver transplant status".
And, "The deleterious effects of obesity on liver disease and overall health can be significantly impacted by a culture that fosters sustained nutritional improvement and regular physical activity".
With an aim to find a natural ingredient for the treatment of liver disease, researchers evaluated the ability of sulforaphane, an activator of Nrf2, to blunt CYP2E1-dependent, ethanol-induced steatosis in vivo and in vitro.
Where Nuclear factor (erythroid-derived 2)-like 2, (Nrf2), is a pro-antioxidant protein that plays a critical role in protecting our body against oxidative damage triggered by injury and inflammation.
And CYP2E1 is a protein involved in the metabolism of xenobiotics in the body.
The application of sulforaphane (SFN) treatment increased the levels of antioxidants by activating the levels of the Nrf2 and lowering oxidant stress observed by the decline in lipid peroxidation and increase in glutathione (GSH) levels.
SFN also decreased liver levels of triglycerides and cholesterol elevated by the injection of ethanol.
The results strongly suggested that SFN inhibited liver disease by increasing the expression of antioxidant enzymes and lowing the expression of free radicals as well as reducing the liver fat deposits.
Moreover, in the investigation to determine whether glucoraphanin and its breakdown product sulforaphane, are potent modulators of various phase I and phase II enzymes involved in carcinogen-metabolizing enzyme systems in vitro, researchers showed that injection of glucoraphanin at higher concentrations (25 μM) decreased dealkylation of methoxyresorufin, a marker for cytochrome P4501 activity
Where cytochrome P4501 is an enzyme involved in the metabolism of endogenous substrates and drugs, as well as the activation of certain toxins and environmental pollutants.
Compared to glucoraphanin, sulforaphane is superior to its precursor in modulating carcinogen-metabolizing enzyme systems in vitro.
The University of Rhode Island, Kingston study also suggested that SF activates Nrf2 activation in inhibited lipid accumulation in white adipose tissue, suppressed adipogenesis, insulin resistance, glucose intolerance, and hepatic steatosis in Lep(ob/ob) mice.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis by Zhou R1, Lin J, Wu D.(PubMed)
(2) Sulforaphane is superior to glucoraphanin in modulating carcinogen-metabolizing enzymes in Hep G2 cells by Abdul Razis AF1, Noor NM. (PubMed)
(3) Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice by Xu J1, Kulkarni SR, Donepudi AC, More VR, Slitt AL. (PubMed)
(4) The role of lifestyle changes in the management of chronic liver disease by Valerio Nobili, Christine Carter-Kent,2, and Ariel E Feldstein. (PMC)
#BeetRoots Exert A Chemopreventive Effect Associated with a Significant Inhibition on #SkinCancers in Vivo and Vitro, Researchers Reveal
Kyle J. Norton
Beet or beetroot may have a therapeutic potential in the inhibited onset of skin cancer, some scientists suggested.
Skin cancer is a medical condition characterized by abnormal skin cell growth in disordered and uncontrollable ways.
Skin cancer is still a major cause of morbidity and mortality in the US. According to a statistic provided by the Skin Cancer Foundation, approximately, 5.4 million cases of nonmelanoma skin cancer were treated in over 3.3 million people in the U.S., in 2012.
Noticeably, 1 in 5 Americans will develop skin cancer by the age of 70.
According to general belief, the major cause of skin cancer is accumulative sun exposure. However, most people do not know, accumulative sun exposure during childhood also plays an important role in the increased risk of skin cancer in adulthood.
Truly, occupation chemical exposure, aging, and ethnicity are prevalent risks of skin cancer onset.
People with genetic or acquired genetic mutation genes such as NLRP1 may also be associated with a substantially increased risk of skin cancer(4).
The Singapore Institute of Molecular and Cellular Biology in a joint study, wrote, "A group of non-fever inflammasome disorders, uncover an unexpected auto-inhibitory function for the pyrin domain, and provide the first genetic evidence linking NLRP1 to skin inflammatory syndromes and skin cancer predisposition".
Beet, best known as the beetroot or garden beet and belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.
Beet with a high amount of organic nitrate may have a profound effect on risk factors and treatment of skin cancer.
According to Howard University, in the analysis of beetroot, anti-skin cancer effect in vivo, the measurement from bioassays, beetroot has a chemopreventive effect in expressed a significant inhibition on skin tumors of tested mice.
In skin tumor initiation by 390 nmol of 7,12-dimethylbenz(a)anthracene (DMBA) in 100 microl of acetone together with mouse skin tumor promotion with 3430 J/m(2) of ultraviolet light-B (UV-B), researchers found that administration of 0.0025% and topical application of 390 nmol of betanin, the major chemical constituent isolated from beetroot, reveal strong protection in the mouse skin cancer model.
Besides skin cancer, betanin, a regularly consumed natural product colorant found in abundance in beetroot may also be an effective chemopreventive agent in treating other types of cancer, such as lung and liver cancers.
Others in validated sugar beet pectin/gelatin hydrogels, in vivo, in conjunction with the anti-cancer chemo drug, doxorubicin, demonstrated a successfully suppressed growth of a solid tumor created by applied to the skin of mouse melanoma B16F1 cells into nude mice.
The findings reveal that beet, with high amounts of nitrate, may be used as a therapeutic and functional food in attenuating the risk and treatment of skin cancer alone or combined with other chemo agents.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract by Kapadia GJ1, Tokuda H, Konoshima T, Nishino H.(PubMed)
(2) Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot by Kapadia GJ1, Azuine MA, Sridhar R, Okuda Y, Tsuruta A, Ichiishi E, Mukainake T, Takasaki M, Konoshima T, Nishino H, Tokuda H.(PubMed)
(3) Injectable and biodegradable sugar beet pectin/gelatin hydrogels for biomedical applications by Takei T1, Sugihara K, Yoshida M, Kawakami K.(PubMed)
(4) Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation by Zhong FL1, Mamaï O2, Sborgi L3, Boussofara L4, Hopkins R5, Robinson K6, Szeverényi I6, Takeichi T7, Balaji R6, Lau A6, Tye H8, Roy K6, Bonnard C6, Ahl PJ5, Jones LA5, Baker PJ8, Lacina L6, Otsuka A9, Fournie PR10, Malecaze F10, Lane EB6, Akiyama M11, Kabashima K12, Connolly JE5, Masters SL8, Soler VJ10, Omar SS13, McGrath JA14, Nedelcu R15, Gribaa M16, Denguezli M4, Saad A16, Hiller S3, Reversade B(PubMed)
Beet or beetroot may have a therapeutic potential in the inhibited onset of skin cancer, some scientists suggested.
Skin cancer is a medical condition characterized by abnormal skin cell growth in disordered and uncontrollable ways.
Skin cancer is still a major cause of morbidity and mortality in the US. According to a statistic provided by the Skin Cancer Foundation, approximately, 5.4 million cases of nonmelanoma skin cancer were treated in over 3.3 million people in the U.S., in 2012.
Noticeably, 1 in 5 Americans will develop skin cancer by the age of 70.
According to general belief, the major cause of skin cancer is accumulative sun exposure. However, most people do not know, accumulative sun exposure during childhood also plays an important role in the increased risk of skin cancer in adulthood.
Truly, occupation chemical exposure, aging, and ethnicity are prevalent risks of skin cancer onset.
People with genetic or acquired genetic mutation genes such as NLRP1 may also be associated with a substantially increased risk of skin cancer(4).
The Singapore Institute of Molecular and Cellular Biology in a joint study, wrote, "A group of non-fever inflammasome disorders, uncover an unexpected auto-inhibitory function for the pyrin domain, and provide the first genetic evidence linking NLRP1 to skin inflammatory syndromes and skin cancer predisposition".
Beet, best known as the beetroot or garden beet and belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.
Beet with a high amount of organic nitrate may have a profound effect on risk factors and treatment of skin cancer.
According to Howard University, in the analysis of beetroot, anti-skin cancer effect in vivo, the measurement from bioassays, beetroot has a chemopreventive effect in expressed a significant inhibition on skin tumors of tested mice.
In skin tumor initiation by 390 nmol of 7,12-dimethylbenz(a)anthracene (DMBA) in 100 microl of acetone together with mouse skin tumor promotion with 3430 J/m(2) of ultraviolet light-B (UV-B), researchers found that administration of 0.0025% and topical application of 390 nmol of betanin, the major chemical constituent isolated from beetroot, reveal strong protection in the mouse skin cancer model.
Besides skin cancer, betanin, a regularly consumed natural product colorant found in abundance in beetroot may also be an effective chemopreventive agent in treating other types of cancer, such as lung and liver cancers.
Others in validated sugar beet pectin/gelatin hydrogels, in vivo, in conjunction with the anti-cancer chemo drug, doxorubicin, demonstrated a successfully suppressed growth of a solid tumor created by applied to the skin of mouse melanoma B16F1 cells into nude mice.
The findings reveal that beet, with high amounts of nitrate, may be used as a therapeutic and functional food in attenuating the risk and treatment of skin cancer alone or combined with other chemo agents.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract by Kapadia GJ1, Tokuda H, Konoshima T, Nishino H.(PubMed)
(2) Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot by Kapadia GJ1, Azuine MA, Sridhar R, Okuda Y, Tsuruta A, Ichiishi E, Mukainake T, Takasaki M, Konoshima T, Nishino H, Tokuda H.(PubMed)
(3) Injectable and biodegradable sugar beet pectin/gelatin hydrogels for biomedical applications by Takei T1, Sugihara K, Yoshida M, Kawakami K.(PubMed)
(4) Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation by Zhong FL1, Mamaï O2, Sborgi L3, Boussofara L4, Hopkins R5, Robinson K6, Szeverényi I6, Takeichi T7, Balaji R6, Lau A6, Tye H8, Roy K6, Bonnard C6, Ahl PJ5, Jones LA5, Baker PJ8, Lacina L6, Otsuka A9, Fournie PR10, Malecaze F10, Lane EB6, Akiyama M11, Kabashima K12, Connolly JE5, Masters SL8, Soler VJ10, Omar SS13, McGrath JA14, Nedelcu R15, Gribaa M16, Denguezli M4, Saad A16, Hiller S3, Reversade B(PubMed)
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