Kyle J. Norton
Arnica may have a profound and positive effect in reduced pain and numbness caused by inflammatory muscles, some scientists suggested.
The results were demonstrated in some research papers conducted by a number of institutes, including the University of Exeter.
Muscle pain is a natural reaction of the human brain that protects our body against muscle damage and injuries by the activated immune response in signaling systemic inflammation in the acute phase of infection.
However, overproduction of pro-inflammatory cytokines may cause damage to the nearby healthy cells and death of injured cells in the area, leading to irreversible scars of the skin and tissue.
The most common causes of muscle pain are localized with tension, stress, overuse,...... and minor injuries. However Systemic muscle pain caused by infection and side effects of medication intake can induce pain throughout the entire body.
According to Safe Medicine, people who are taking medications that treat high blood cholesterol such as atorvastatin, pravastatin, simvastatin, pitavastatin, and rosuvastatin are likely to experience muscle pain.
Chronic muscle pain caused by complications of chronic diseases such as chronic exertional compartment syndrome, chronic fatigue syndrome, fibromyalgia,.... and claudication dermatomyositis are associated to increase psychological symptoms such as depression and physical symptoms of a sleep disorder such as insomnia and reduced quality of life.
Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, and used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is a process of repairing the damage to skin, tissues, organs, etc.
In the study to evaluate the arnica patch effect in a 55-year-old female patient with pain in the right hand and numbness in the fourth finger after cellulitis in the palmar area, after the failure of antibiotics to alleviate pain observed by reading the indication 0-to-10-point visual analog scale (VAS).
The pain symptoms remained at 7 points after injection of ibuprofen, the conventional pain medicine.
According to the result of the study topical administration after 3 days of Arnica patch stripped to cover all painful areas of the hand and applied at night exerted a pain and numbness relief and reduced size of a tender nodule on the third metacarpal area.
The self-report pain scale reading of 1, also marked a significant reduction and efficacy of the topical herbal Arnica.
Furthermore, the tested patient was able to sleep through the night without being awakened by the pain.
Moreover, all symptoms declined even more during the next 2 days.
Dr. Barkey E, after taking into account co and confounders said, " after a relatively short period of time, the administration of the Arnica patch on the hand provided a marked reduction of pain and recovery of the functionality of the hand".
These results suggested that Arnica may have a therapeutic effect in inhibiting particular pro-inflammatory cytokines in the initiation of the persistence of pathologic pain by directly activating nociceptive sensory neurons without reducing the activities of immune activity in protecting the body tissues against infectious microorganisms.
Some researchers suggested that these results may also be attributed to Arnica's ability to inhibit overexpression of reactive oxygen species (ROS) induction of inflammation through its antioxidant bioactive phytochemicals and stimulation of the production of antioxidant defense in the host body and tissue.
Truly, by balancing the ratio of ROS and levels of antioxidants in the body, and inhibiting the production of pro-inflammatory factors, Arnica may have the potential effect to alleviate pain and numbness of infectious muscles, joints, and hands of the patients.
Interestingly, in a double-blind, randomized comparison of Arnica administration versus placebo of a total of 37 patients undergoing bilateral endoscopic carpal tunnel release between June 1998 and January 2000 at the Queen Victoria NHS Trust. researchers found that there were no group differences in the primary outcome measures of grip strength or wrist circumference.
However, the Arnica treatment group showed a significant reduction in pain experienced after 2 weeks in compared to the control.
Although Arnica application displayed strong properties in reduced pain symptoms of the tested patients, due to the small size of the sample, Dr. Stevinson C, the lead scientist said, "The role of homeopathic and herbal agents for recovery after surgery merits further investigation".
Taken together, topical herbal Arnica may be considered as a potential secondary therapeutic treatment in alleviated pain and numbness, particularly, in the patient who experiences some intolerant adverse effect induced by the intake of conventional medicine.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A Homeopathic Arnica Patch for the Relief of Cellulitis-derived Pain and Numbness in the Hand by Barkey E1, Kaszkin-Bettag M.(PubMed)
(2) Homeopathic arnica for prevention of pain and bruising: randomized placebo-controlled trial in hand surgery by Stevinson C1, Devaraj VS, Fountain-Barber A, Hawkins S, Ernst E.(PubMed)
(3) Use of Arnica to relieve pain after carpal tunnel release surgery by Jeffrey SL1, Belcher HJ. (PubMed)
Tuesday, 4 July 2023
#Phytochemical #Polysulfides Found in the #GarlicExtracts or #Essentialoils Process Anti #Bacterial and #Fungal Infection Activities, Researchers Found
Kyle J. Norton
Scientists may have found a natural antibiotic for the prevention and treatment of bacterial infection, according to the study.
Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belongings to the group ofOrganosulfides found abundantly in the oxidized product, including beer, wine, whiskey, garlic oil, etc.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.
The immune system does a great job of keeping people healthy and preventing infections.
How the immune system protects against infection. As soon as sensing the physical injury in the body, the white blood cells of the immune first line of defense not only activates the protein associated with the coagulation to cover the wound but also stimulates the production of pro-inflammatory cytokines to kill off the foreign invaders.
However, in most cases, overexpression of proinflammatory cytokines can cause death and damage to nearby health, leading to abnormal tissue healing with the formation of scars.
For example overexpression of proinflammatory cytokines produced during the hepatitis infection can induce irreversible liver scars, leading to chronic liver disease, such as cirrhosis.
Some researchers in the examine the immune evolution history, suggested that the immune system must kill off the invaders with 3 to 8 weeks during the acute phase of infection, otherwise, it will adapt to the change, causing low-grade inflammation, such as type 1 diabetes mellitus, coeliac disease, inflammatory bowel disease, and rheumatoid arthritis.
According to the study by the Memorial University of Newfoundland, in the micronutrients perspectively, zinc; selenium; iron; copper; vitamins A, C, E, and B-6; and folic acid have important influences on immune responses" and "Overnutrition and obesity also reduce immunity and protein-energy malnutrition is associated with a significant impairment of cell-mediated immunity, phagocyte function, complement system, secretory immunoglobulin A antibody concentrations, and cytokine production".
These results indicated beside foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.
In order to understand the range of sulfur-containing natural products from plants in the inhibition of fungi, and bacteria infection, researchers investigated the biological activity of these compounds that affect human immunity.
Polysulfides, one of the bioactive compound from the group, exerted a significant redox activity by increasing the expression of antioxidants (catalysis, metal binding) enzymes in inhibiting the radical generation and protecting the integrity of DNA and cellular membranes.
Furthermore, in order to exert the maximum effect in immunity, the biological activity of polysulfides depends on initial antioxidant-enzymatic activation to be generated with high target selectivity.
Moreover, in examing the polysulfides activity against the increase in the number of systemic fungal diseases, researchers showed that polysulfides found in the garlic extracts or essential oils demonstrated a clinically significant effect on fungal infection. the bioactive compound was considered an alternative way of protecting of foodstuffs from contamination.
In vitro and in vivo, polysulfide derivatives isolated by chemical reaction also exhibited potent antifungal activity against candidosis in the tested mice.
Taken altogether, Polysulfides isolated from garlic may have a therapeutic effect in improving the immune activity against bacterial and fungal infections with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) A scent of therapy: pharmacological implications of natural products containing redox-active sulfur atoms by Jacob C.(PubMed)
(2) [Pharmaceutical significance of Allium sativum L. 4. Antifungal effects].[Article in Czech]by Sovová M1, Sova P.(PubMed)
(3) Optically active antifungal azoles. II. Synthesis and antifungal activity of polysulfide derivatives of (2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H- 1,2,4-triazol-1-yl)-2-butanol by Tasaka A1, Tamura N, Matsushita Y, Hayashi R, Okonogi K, Itoh K.(PubMed)
(4) Nutrition and the immune system: an introduction by Chandra RK. (PubMed)
Scientists may have found a natural antibiotic for the prevention and treatment of bacterial infection, according to the study.
Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belongings to the group ofOrganosulfides found abundantly in the oxidized product, including beer, wine, whiskey, garlic oil, etc.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases.
The immune system does a great job of keeping people healthy and preventing infections.
How the immune system protects against infection. As soon as sensing the physical injury in the body, the white blood cells of the immune first line of defense not only activates the protein associated with the coagulation to cover the wound but also stimulates the production of pro-inflammatory cytokines to kill off the foreign invaders.
However, in most cases, overexpression of proinflammatory cytokines can cause death and damage to nearby health, leading to abnormal tissue healing with the formation of scars.
For example overexpression of proinflammatory cytokines produced during the hepatitis infection can induce irreversible liver scars, leading to chronic liver disease, such as cirrhosis.
Some researchers in the examine the immune evolution history, suggested that the immune system must kill off the invaders with 3 to 8 weeks during the acute phase of infection, otherwise, it will adapt to the change, causing low-grade inflammation, such as type 1 diabetes mellitus, coeliac disease, inflammatory bowel disease, and rheumatoid arthritis.
According to the study by the Memorial University of Newfoundland, in the micronutrients perspectively, zinc; selenium; iron; copper; vitamins A, C, E, and B-6; and folic acid have important influences on immune responses" and "Overnutrition and obesity also reduce immunity and protein-energy malnutrition is associated with a significant impairment of cell-mediated immunity, phagocyte function, complement system, secretory immunoglobulin A antibody concentrations, and cytokine production".
These results indicated beside foods and nutritional supplements, herbs also play an important role in helping the immune system defend against viruses and bacteria attacks.
In order to understand the range of sulfur-containing natural products from plants in the inhibition of fungi, and bacteria infection, researchers investigated the biological activity of these compounds that affect human immunity.
Polysulfides, one of the bioactive compound from the group, exerted a significant redox activity by increasing the expression of antioxidants (catalysis, metal binding) enzymes in inhibiting the radical generation and protecting the integrity of DNA and cellular membranes.
Furthermore, in order to exert the maximum effect in immunity, the biological activity of polysulfides depends on initial antioxidant-enzymatic activation to be generated with high target selectivity.
Moreover, in examing the polysulfides activity against the increase in the number of systemic fungal diseases, researchers showed that polysulfides found in the garlic extracts or essential oils demonstrated a clinically significant effect on fungal infection. the bioactive compound was considered an alternative way of protecting of foodstuffs from contamination.
In vitro and in vivo, polysulfide derivatives isolated by chemical reaction also exhibited potent antifungal activity against candidosis in the tested mice.
Taken altogether, Polysulfides isolated from garlic may have a therapeutic effect in improving the immune activity against bacterial and fungal infections with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) A scent of therapy: pharmacological implications of natural products containing redox-active sulfur atoms by Jacob C.(PubMed)
(2) [Pharmaceutical significance of Allium sativum L. 4. Antifungal effects].[Article in Czech]by Sovová M1, Sova P.(PubMed)
(3) Optically active antifungal azoles. II. Synthesis and antifungal activity of polysulfide derivatives of (2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H- 1,2,4-triazol-1-yl)-2-butanol by Tasaka A1, Tamura N, Matsushita Y, Hayashi R, Okonogi K, Itoh K.(PubMed)
(4) Nutrition and the immune system: an introduction by Chandra RK. (PubMed)
#Mixture of Tri- and Tetrameric Cyclic I3C Derivatives (CTr/CTet) Inhibits #BreastCancer Cell Proliferation, Inducing the G0/1 Cell Cycle Phase Accumulation, Researchers Say
Kyle J. Norton
Indole-3-carbinol may be the pharmaceutical target in the search for a chemo drug doe the treatment of breast cancer, some scientists suggested.
As a phytochemical in the class of Indoles, Indole-3-carbinol processes a unique function by the breaking down of the glucosinolate glucobrassicin found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.
Breast cancer is a medical and chronic condition caused by cell growth irregularly and uncontrollably in the breast tissue. At the early stage, in most case breast cancer starts in the cells of the inner lining tissue of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the advanced stage, breast cancer cells caused by alternation of DNA can travel far the way from the primary site to infect other healthy tissue and organs.
Most patients at the early may have a lump when touching with no symptoms.
Patients who inherited the genetic preposition of BRCA1 and 2 are associated with over 60% of the risk of breast cancer.
However, an unhealthy diet and lifestyle are some of the preventable risk factors that form a major cause of breast cancer onset.
Dr. Harvie M, the lead scientist on the breast cancer program team at the University Hospital of South Manchester NHS Foundation Trust, said, " The World Cancer Research Fund (WCRF) and American Cancer Society (ACS) cancer prevention guidelines recommend maintaining a healthy weight, undertaking at least 150 minutes of moderate-intensity exercise per week, limiting alcohol consumption, and eating a plant-based" and "Lifestyle factors appear to modify risk among high-risk women with a family history and those with typical risk of the general population".
In Post menopause, weight control is the major factor throughout life that appears to prevent breast cancer after menopause.
Daily physical activity and reduced intake of alcohol throughout life are associated with reduced risk of developing pre- and postmenopausal breast cancer, however, smoking during adolescence or early adulthood increases later risk of breast cancer.
Interestingly, in the depth discussion of the diet pattern in the risk of breast cancer, researchers do not find a direct link to breast cancer risk.
These results suggested by actively following a healthy lifestyle and moderate exercise, the risk of breast cancer can be decreased substantially.
The team on the final report said, "Recent expert reports estimate that successful lifestyle changes could prevent 25% to 30% of cases of breast cancer".
According to the statistic, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.
Dr. the lead author in the research team of the cancer program in the investigation to examine the effect of indole-3-carbinol cyclic tetrameric derivative (CTet) in breast cancer cell proliferation by endoplasmic reticulum stress and autophagy-related cell death induction conducted an experiment to evaluated the synergistic activity of CTet in combination with cisplatin and doxorubicin in triple-negative breast cancer cell lines.
In MDA included -MB-231 and BT-20 triple-negative breast cancer cells, CTet in combination with both cisplatin and doxorubicin synergistically inhibits cell viability and induces autophagy.
The efficacy of the CTet and combination exerted a strong anti-cancer effect as seen in the MAP1LC3B gene that is responsible for a normal physiological process in the body in dealing with the destruction of cells.
Pre-treated with cisplatin and doxorubicin demonstrated a strong cytotoxic activity of CTet in cells in the tested cancer cell lines.
The findings reaffirmed the potential of CTet as a chemopreventive agent or chemotherapeutic in combination with standard approaches for triple-negative breast cancer.
Furthermore, indole-3-carbinol cyclic tetrameric derivative CTet induces autophagy and inhibits breast cancer cell proliferation, researchers at the University of Urbino Carlo Bo conducted an investigation to examine the antitumoral activity of a mixture of tri- and tetrameric cyclic I3C derivatives (CTr/CTet) both in vitro (MCF-7 and MDA-MB-231 breast cancer cell lines.
Observation of the application on the tested cancer cell line suggested CTr/CTet mixture inhibits breast cancer cell proliferation (IC50 = 1.3 and 1.6 μg/ml in MCF-7 and MDAMB- 231, respectively) inducing the G0/1 cell cycle phase accumulation.
The efficacy was attributed to the mixture in activating the overexpression of p21, p27, and GADD45A, which are the cell cycle regulators, nuclear translocation of FOXO3ain the induction of cell apoptosis and inhibition of Akt activity and downregulation of estrogen receptor.in stimulating cancer cell proliferation.
Moreover, n vivo, the tumor growth of xenotransplanted was also inhibited by reducing the function of Cyclin E and its low molecular weight which is important in the transition from G1 to S phase of the cell cycle that determines initiation of DNA duplication.
Taken altogether, Indole-3-carbinol processed apoptotic and antiproliferative activity can be considered a functional supplement for the prevention and combined with primary medicine for the treatment of breast cancer.
However, further data collection large example size, and multi-center studies performed with human consumption of the phytochemical during the course of the disease will be necessary to complete the picture of Indole-3-carbinol anti-breast cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The Indole-3-carbinol cyclic tetrameric derivative CTet synergizes with cisplatin and doxorubicin in triple-negative breast cancer cell lines by De Santi M1, Galluzzi L, Duranti A, Magnani M, Brandi G.(PubMed)
(2) Antitumoral activity of indole-3-carbinol cyclic tri- and tetrameric derivatives mixture in human breast cancer cells: in vitro and in vivo studies by Brandi G1, Fraternale A, Lucarini S, Paiardini M, De Santi M, Cervasi B, Paoletti MF, Galluzzi L, Duranti A, Magnani M.(PubMed).
(3) Can diet and lifestyle prevent breast cancer: what is the evidence? by Harvie M1, Howell A1, Evans DG. (PubMed)
Indole-3-carbinol may be the pharmaceutical target in the search for a chemo drug doe the treatment of breast cancer, some scientists suggested.
As a phytochemical in the class of Indoles, Indole-3-carbinol processes a unique function by the breaking down of the glucosinolate glucobrassicin found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.
Breast cancer is a medical and chronic condition caused by cell growth irregularly and uncontrollably in the breast tissue. At the early stage, in most case breast cancer starts in the cells of the inner lining tissue of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the advanced stage, breast cancer cells caused by alternation of DNA can travel far the way from the primary site to infect other healthy tissue and organs.
Most patients at the early may have a lump when touching with no symptoms.
Patients who inherited the genetic preposition of BRCA1 and 2 are associated with over 60% of the risk of breast cancer.
However, an unhealthy diet and lifestyle are some of the preventable risk factors that form a major cause of breast cancer onset.
Dr. Harvie M, the lead scientist on the breast cancer program team at the University Hospital of South Manchester NHS Foundation Trust, said, " The World Cancer Research Fund (WCRF) and American Cancer Society (ACS) cancer prevention guidelines recommend maintaining a healthy weight, undertaking at least 150 minutes of moderate-intensity exercise per week, limiting alcohol consumption, and eating a plant-based" and "Lifestyle factors appear to modify risk among high-risk women with a family history and those with typical risk of the general population".
In Post menopause, weight control is the major factor throughout life that appears to prevent breast cancer after menopause.
Daily physical activity and reduced intake of alcohol throughout life are associated with reduced risk of developing pre- and postmenopausal breast cancer, however, smoking during adolescence or early adulthood increases later risk of breast cancer.
Interestingly, in the depth discussion of the diet pattern in the risk of breast cancer, researchers do not find a direct link to breast cancer risk.
These results suggested by actively following a healthy lifestyle and moderate exercise, the risk of breast cancer can be decreased substantially.
The team on the final report said, "Recent expert reports estimate that successful lifestyle changes could prevent 25% to 30% of cases of breast cancer".
According to the statistic, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of women is 1/8.
Dr. the lead author in the research team of the cancer program in the investigation to examine the effect of indole-3-carbinol cyclic tetrameric derivative (CTet) in breast cancer cell proliferation by endoplasmic reticulum stress and autophagy-related cell death induction conducted an experiment to evaluated the synergistic activity of CTet in combination with cisplatin and doxorubicin in triple-negative breast cancer cell lines.
In MDA included -MB-231 and BT-20 triple-negative breast cancer cells, CTet in combination with both cisplatin and doxorubicin synergistically inhibits cell viability and induces autophagy.
The efficacy of the CTet and combination exerted a strong anti-cancer effect as seen in the MAP1LC3B gene that is responsible for a normal physiological process in the body in dealing with the destruction of cells.
Pre-treated with cisplatin and doxorubicin demonstrated a strong cytotoxic activity of CTet in cells in the tested cancer cell lines.
The findings reaffirmed the potential of CTet as a chemopreventive agent or chemotherapeutic in combination with standard approaches for triple-negative breast cancer.
Furthermore, indole-3-carbinol cyclic tetrameric derivative CTet induces autophagy and inhibits breast cancer cell proliferation, researchers at the University of Urbino Carlo Bo conducted an investigation to examine the antitumoral activity of a mixture of tri- and tetrameric cyclic I3C derivatives (CTr/CTet) both in vitro (MCF-7 and MDA-MB-231 breast cancer cell lines.
Observation of the application on the tested cancer cell line suggested CTr/CTet mixture inhibits breast cancer cell proliferation (IC50 = 1.3 and 1.6 μg/ml in MCF-7 and MDAMB- 231, respectively) inducing the G0/1 cell cycle phase accumulation.
The efficacy was attributed to the mixture in activating the overexpression of p21, p27, and GADD45A, which are the cell cycle regulators, nuclear translocation of FOXO3ain the induction of cell apoptosis and inhibition of Akt activity and downregulation of estrogen receptor.in stimulating cancer cell proliferation.
Moreover, n vivo, the tumor growth of xenotransplanted was also inhibited by reducing the function of Cyclin E and its low molecular weight which is important in the transition from G1 to S phase of the cell cycle that determines initiation of DNA duplication.
Taken altogether, Indole-3-carbinol processed apoptotic and antiproliferative activity can be considered a functional supplement for the prevention and combined with primary medicine for the treatment of breast cancer.
However, further data collection large example size, and multi-center studies performed with human consumption of the phytochemical during the course of the disease will be necessary to complete the picture of Indole-3-carbinol anti-breast cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The Indole-3-carbinol cyclic tetrameric derivative CTet synergizes with cisplatin and doxorubicin in triple-negative breast cancer cell lines by De Santi M1, Galluzzi L, Duranti A, Magnani M, Brandi G.(PubMed)
(2) Antitumoral activity of indole-3-carbinol cyclic tri- and tetrameric derivatives mixture in human breast cancer cells: in vitro and in vivo studies by Brandi G1, Fraternale A, Lucarini S, Paiardini M, De Santi M, Cervasi B, Paoletti MF, Galluzzi L, Duranti A, Magnani M.(PubMed).
(3) Can diet and lifestyle prevent breast cancer: what is the evidence? by Harvie M1, Howell A1, Evans DG. (PubMed)
The Anti #OverGrowth of #CandidaAlbicans Natural Remedies
Kyle J. Norton
Candida albicans are members of a large group of a microorganism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to a joint study, in many cases, biofilm(microorganisms with cells sticking to each other on a surface) formation(7) gene mutations(8), and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.
Herbal medicine or phytotherapy is a traditional practice that used botany and plants for the treatment of a variety of diseases.
Today, due to serious side effects caused by the intake of conventional single-ingredient medication, some scientists once again have looked into herbal whole food plants with an aim to find replacements with similar effects without inducing the adverse effect.
These journeys have encountered many problems, as the discovery of such plants will provide no commercial benefit and patent right to producers. Particularly, if such plants are found, they will exert a major blow in cutting into sizable benefits of big pharmaceutical companies
Truly, between 25 to 50% of current pharmaceuticals are derived from plants, and none are used as antimicrobials(b).
Some researchers suggested that duplicated herbal successes of Western drugs with the synthetic version for the patent right without using the whole herb ingredients for commercial profits may eventually contribute to the overexpression of serious adverse effects(b).
The imbalance of the ratio of ROS species and antioxidant enzymes in the host tissue has played an essential role in the initiated expression of healthy cell cytotoxicity that can alternate DNA transcription in facilitating the development of chronic ailments such as the overgrowth of candida.
In free radical overexpression caused by overgrowth candida, certain natural alternatives exerted a strong antioxidant effect that targets Candida.
According to Dr. Seneviratne CJ at the University of Hong Kong, in the study of "Potent anti-traditional Chinese herbal plant contains significant and potent antifungal activities, such as Rhizoma Coptidis and Cortex phellodendri Chinesis on three different non-albicans Candida species, C. glabrata, C. krusei and C. tropicalis(a).
The Anti Over Growth of Candida Natural Alternatives
1. Manuka Honey
Manuka honey has been known to benefit humans in healing wounds and injuries(309) without inducing damage to cells. The product also contains hydrogen peroxide claimed to have antimicrobial properties (310), including Candida albicans(311).
2. Undecylenic acid
Undecylenic acid is the common name of the 10-undecenoic acid, an organic unsaturated fatty acid derived from castor oil, It is a natural antimicrobial property(312)against fungal skin infections(313)(314) and Candida albicans(315).
3. Caprylic acid
Caprylic acid is the common name for the eight-carbon saturated fatty acid found naturally in coconuts and breast milk, used in treatments for a variety of conditions, including Candida(316)(317).
4. Echinacea angustifolia
Echinacea angustifolia is a herbaceous plant species Echinacea angustifolia, belongings to the family Asteraceae native to Northern America. Echinacea angustifolia besides enhancing the immune system function(318)(319) against the invasion of bacteria and viral through its antioxidant effects, is also used to treat bacterial infections(320) and candida(318) in herb medicine.
5. Horopeito
Horopeit is a genus Pseudowintera, part of the family Winteraceae. The herb contains a compound polygonal, a chemical compound used to suppress the growth of candida(321)(322) by damaging the permeable cell membrane of yeast(322).
6. Oregano
Oregano is a genus of the mint family Lamiaceae, native to southwestern Eurasia and the Mediterranean region. The herb not only promotes digestive health(323), clear skin, and a healthy immune system(324) but also dehydrates candida(325) by reacting with the water in the bloodstream, through its phytochemicals Carvacrol and Thymol(326).
7. Aloe vera
Aloe vera is a genus Aloe belongings to the family Asphodelaceae, which originated in Sudan. Besides containing significant amounts of amino acids, enzymes, vitamins, minerals, and antioxidants which help to enhance the immune function(327) in fighting against virus and bacterial infection and inflammation(328), it also maintains proper PH levels that inhibit the growth of candida(329) and repairs and seals the intestinal wall, which stops Candida from actually penetrating through and into your bloodstream(330).
8. Tea tree oil
Tea tree oil is a pale yellow color to nearly clear essential oil extracted from the leaves of the Narrow-leaved Tea-tree, native to the northeast coast of New South Wales, Australia. In Fluconazole-resistant candida Albicans strains, dose-depend manner, tea tree oil strongly exhibited fluconazole activity against fluconazole-resistant C. albicans strains, through its antifungal activity(331).
Terpinen-4-ol, the main bioactive component found in tea tree oil, also showed to accelerate clearance of all Candida strains from the vagina, including the azole-resistant forms in rat vaginal infection model(332)
9. Tannate plant extracts
Tannate is the salt or ester of tannic acid. Tannate plant extract is a powerful antifungal agent(333)(334) by destroying candida selectively without harming the good flora in the body(335). It is said that tannate plant extract is effective in treating bacteria, viruses, and fungal infections due to its antifungal(333)(334), and anti-inflammatory properties(336).
10. Biotin
Biotin or vitamin B7, a coenzyme in the metabolism of fatty acids and leucine, plays an important role in gluconeogenesis(337). According to Università degli Studi di Torino, patients with biotin deficiency are at high risk of candida albicans overgrowth(338).
Biotin prevents yeast to change into its fungal form(339), thus reducing the risk of candida albicans overgrowth.
11. Probiotics (friendly bacteria)
Probiotic is live microorganisms that benefit the host. Intake of probiotics enhances the production of hydrogen peroxide(340) which plays an important role in preventing candida overgrowth and through self-multiple mechanisms(341).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(a) The potent anti-microbial activity of traditional Chinese medicine herbs against Candida species by Seneviratne CJ1, Wong RW, Samaranayake LP.(PubMed)
(b) Plant Products as Antimicrobial Agents by Marjorie Murphy Cowan(PMC)(1) Non-albicans Candida spp. causing fungemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ. (PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in the yeast Candida by Prasad R1, Kapoor K.(PubMed)
(4) New evidence that Candida albicans possess additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ. (PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of the antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)(247) The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging. by Moriguchi S1.(PubMed)
(310) Effect of hydrogen peroxide on antibacterial activities of Canadian honey by Brudzynski K1.(PubMed)
(311) Streptomyces sp. JS520 produces exceptionally high quantities of undecylprodigiosin with antibacterial, antioxidative, and UV-protective properties by Stankovic N1, Radulovic V, Petkovic M, Vuckovic I, Jadranin M, Vasiljevic B, Nikodinovic-Runic J.(PubMed)
(312) Antimicrobial polyurethane thermosets based on undecylenic acid: synthesis and evaluation.by Lluch C1, Esteve-Zarzoso B, Bordons A, Lligadas G, Ronda JC, Galià M, Cádiz V.(PubMed)
(313) Allergic contact dermatitis from undecylenic acid in a commercial antifungal nail solution by Anguita JL1, Escutia B, Marí JI, Rodríguez M, De La Cuadra J, Aliaga A.(PubMed)
(314) Undecylenic acid and fungous infections by Landau JW.(PubMed)
(315) Undecylenic acid inhibits morphogenesis of Candida albicansby McLain N1, Ascanio R, Baker C, Strohaver RA, Dolan JW.(PubMed)
(316) [Inhibition of Candida mycelia growth by a medium chain fatty acids, capric acid in vitro and its therapeutic efficacy in murine oral candidiasis].[Article in Japanese]by Takahashi M1, Inoue S, Hayama K, Ninomiya K, Abe S.(PubMed)
(317) [Effects of inhibitory activity on mycelial growth of Candida albicans and therapy for murine oral candidiasis by the combined use of terpinen-4-ol and a middle-chain fatty acid, capric acid].[Article in Japanese]by Ninomiya K1, Hayama K, Ishijima S, Takahashi M, Kurihara J, Abe S.(PubMed)
(318) In vitro and in vivo immune-stimulating effects of a new standardized Echinacea angustifolia root extract (Polinacea) by Morazzoni P1, Cristoni A, Di Pierro F, Avanzini C, Ravarino D, Stornello S, Zucca M, Musso T.(PubMed)
(319) Immune enhancing effects of Echinacea purpurea root extract by reducing regulatory T cell number and function by Kim HR, Oh SK, Lim W, Lee HK, Moon BI, Seoh JY.(PubMed)
(320) Applications of the phytomedicine Echinacea purpurea (Purple Coneflower) in infectious diseases. by Hudson JB1.(PubMed)
(321) Anethole, a potential antimicrobial synergist, converts a fungistatic dodecanol to a fungicidal agent Fujita K1, Fujita T, Kubo I.(PubMed)
(322) Polygodial, an antifungal potentiator by Kubo I1, Taniguchi M.(PubMed)
(323) Enterococci from piglets--probiotic properties and responsiveness to natural antibacterial substances by Strompfová V1, Lauková A.(PubMed)
(324) Dietary supplementation with two Lamiaceae herbs-(oregano and sage) modulates innate immunity parameters in Lumbricus terrestris by Vattem DA1, Lester C, Deleon R, Jamison B, Maitin V.(PubMed)
(325) Oregano Oil for Candida(New health guide)(326) In vitro activity of origanum vulgare essential oil against candida species by Cleff MB1, Meinerz AR, Xavier M, Schuch LF, Schuch LF, Araújo Meireles MC, Alves Rodrigues MR, de Mello JR. (PubMed)
(327) Augmented humoral immune response and decreased cell-mediated immunity by Aloe vera in rats. by Halder S1, Mehta AK, Mediratta PK.(PubMed)
(328) Antimicrobial activity of preparation Bioaron C by Gawron-Gzella A, Michalak A, Kędzia A.(PubMed)
(329) Antimicrobial activity of plant extracts on Candida albicans: an in vitro study by Doddanna SJ1, Patel S, Sundarrao MA, Veerabhadrappa RS. (PubMed)
(330) Antifungals: Aloe Vera(The candida diet)
(331) The Influence of Tea Tree Oil (Melaleuca alternifolia) on Fluconazole Activity against Fluconazole-Resistant Candida albicans Strains by Mertas A1, Garbusińska A1, Szliszka E1, Jureczko A1, Kowalska M1, Król W1.(PubMed)
(332) In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species by Mondello F1, De Bernardis F, Girolamo A, Cassone A, Salvatore G.(PubMed)
(333) [The effect of tannic acid on the colonization of Candida in tissue conditioning material].
[Article in Japanese]by Kubota K.(PubMed)(334) [The effect of tannic acid on the attachment of Candida albicans to plate denture lining material].
[Article in Japanese]by Tanaka T.(PubMed)
(335) Who Gets Yeast Infections? (Things for ladies)(336) Evaluation of Phytochemical Screening and Anti Inflammatory Activity of Leaves and Stem of Mikania scandens (L.) Wild by Banerjee S1, Chanda A1, Adhikari A2, Das A2, Biswas S3.(PubMed)
(337) The effect of oxalate on gluconeogenesis by isolated chicken hepatocytes. Increased sensitivity to inhibition as a result of biotin deficiency by Bannister DW, O'Neill IE. (PubMed)
(338) Growth of Candida albicans in a minimal synthetic medium without biotin. by Vidotto V1, Pugliese A, Gioannini P.(PubMed)
(339) Candida Infestation and BiotinWritten by Sean Brookwood Published on September 22, 2013
(340) Improved growth and viability of lactobacilli in the presence of Bacillus subtilis (natto), catalase, or subtilisin by Hosoi T1, Ametani A, Kiuchi K, Kaminogawa S.(PubMed)
(Oxidative stress responses in the human fungal pathogen, Candidaalbicans by Dantas Ada S1, Day A2, Ikeh M3, Kos I4, Achan B5, Quinn J6.(PubMed)
(341) Candida Diets: Part II: Hydrogen Peroxide Written by Jeff McCombs(342) Glutamine supplementation for young infants with severe gastrointestinal disease. by Brown JV1, Moe-Byrne T, McGuire W.(PubMed)
Candida albicans are members of a large group of a microorganism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.
Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).
According to a joint study, in many cases, biofilm(microorganisms with cells sticking to each other on a surface) formation(7) gene mutations(8), and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.
Herbal medicine or phytotherapy is a traditional practice that used botany and plants for the treatment of a variety of diseases.
Today, due to serious side effects caused by the intake of conventional single-ingredient medication, some scientists once again have looked into herbal whole food plants with an aim to find replacements with similar effects without inducing the adverse effect.
These journeys have encountered many problems, as the discovery of such plants will provide no commercial benefit and patent right to producers. Particularly, if such plants are found, they will exert a major blow in cutting into sizable benefits of big pharmaceutical companies
Truly, between 25 to 50% of current pharmaceuticals are derived from plants, and none are used as antimicrobials(b).
Some researchers suggested that duplicated herbal successes of Western drugs with the synthetic version for the patent right without using the whole herb ingredients for commercial profits may eventually contribute to the overexpression of serious adverse effects(b).
The imbalance of the ratio of ROS species and antioxidant enzymes in the host tissue has played an essential role in the initiated expression of healthy cell cytotoxicity that can alternate DNA transcription in facilitating the development of chronic ailments such as the overgrowth of candida.
In free radical overexpression caused by overgrowth candida, certain natural alternatives exerted a strong antioxidant effect that targets Candida.
According to Dr. Seneviratne CJ at the University of Hong Kong, in the study of "Potent anti-traditional Chinese herbal plant contains significant and potent antifungal activities, such as Rhizoma Coptidis and Cortex phellodendri Chinesis on three different non-albicans Candida species, C. glabrata, C. krusei and C. tropicalis(a).
The Anti Over Growth of Candida Natural Alternatives
1. Manuka Honey
Manuka honey has been known to benefit humans in healing wounds and injuries(309) without inducing damage to cells. The product also contains hydrogen peroxide claimed to have antimicrobial properties (310), including Candida albicans(311).
2. Undecylenic acid
Undecylenic acid is the common name of the 10-undecenoic acid, an organic unsaturated fatty acid derived from castor oil, It is a natural antimicrobial property(312)against fungal skin infections(313)(314) and Candida albicans(315).
3. Caprylic acid
Caprylic acid is the common name for the eight-carbon saturated fatty acid found naturally in coconuts and breast milk, used in treatments for a variety of conditions, including Candida(316)(317).
4. Echinacea angustifolia
Echinacea angustifolia is a herbaceous plant species Echinacea angustifolia, belongings to the family Asteraceae native to Northern America. Echinacea angustifolia besides enhancing the immune system function(318)(319) against the invasion of bacteria and viral through its antioxidant effects, is also used to treat bacterial infections(320) and candida(318) in herb medicine.
5. Horopeito
Horopeit is a genus Pseudowintera, part of the family Winteraceae. The herb contains a compound polygonal, a chemical compound used to suppress the growth of candida(321)(322) by damaging the permeable cell membrane of yeast(322).
6. Oregano
Oregano is a genus of the mint family Lamiaceae, native to southwestern Eurasia and the Mediterranean region. The herb not only promotes digestive health(323), clear skin, and a healthy immune system(324) but also dehydrates candida(325) by reacting with the water in the bloodstream, through its phytochemicals Carvacrol and Thymol(326).
7. Aloe vera
Aloe vera is a genus Aloe belongings to the family Asphodelaceae, which originated in Sudan. Besides containing significant amounts of amino acids, enzymes, vitamins, minerals, and antioxidants which help to enhance the immune function(327) in fighting against virus and bacterial infection and inflammation(328), it also maintains proper PH levels that inhibit the growth of candida(329) and repairs and seals the intestinal wall, which stops Candida from actually penetrating through and into your bloodstream(330).
8. Tea tree oil
Tea tree oil is a pale yellow color to nearly clear essential oil extracted from the leaves of the Narrow-leaved Tea-tree, native to the northeast coast of New South Wales, Australia. In Fluconazole-resistant candida Albicans strains, dose-depend manner, tea tree oil strongly exhibited fluconazole activity against fluconazole-resistant C. albicans strains, through its antifungal activity(331).
Terpinen-4-ol, the main bioactive component found in tea tree oil, also showed to accelerate clearance of all Candida strains from the vagina, including the azole-resistant forms in rat vaginal infection model(332)
9. Tannate plant extracts
Tannate is the salt or ester of tannic acid. Tannate plant extract is a powerful antifungal agent(333)(334) by destroying candida selectively without harming the good flora in the body(335). It is said that tannate plant extract is effective in treating bacteria, viruses, and fungal infections due to its antifungal(333)(334), and anti-inflammatory properties(336).
10. Biotin
Biotin or vitamin B7, a coenzyme in the metabolism of fatty acids and leucine, plays an important role in gluconeogenesis(337). According to Università degli Studi di Torino, patients with biotin deficiency are at high risk of candida albicans overgrowth(338).
Biotin prevents yeast to change into its fungal form(339), thus reducing the risk of candida albicans overgrowth.
11. Probiotics (friendly bacteria)
Probiotic is live microorganisms that benefit the host. Intake of probiotics enhances the production of hydrogen peroxide(340) which plays an important role in preventing candida overgrowth and through self-multiple mechanisms(341).
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(a) The potent anti-microbial activity of traditional Chinese medicine herbs against Candida species by Seneviratne CJ1, Wong RW, Samaranayake LP.(PubMed)
(b) Plant Products as Antimicrobial Agents by Marjorie Murphy Cowan(PMC)(1) Non-albicans Candida spp. causing fungemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ. (PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in the yeast Candida by Prasad R1, Kapoor K.(PubMed)
(4) New evidence that Candida albicans possess additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ. (PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of the antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)(247) The role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging. by Moriguchi S1.(PubMed)
(310) Effect of hydrogen peroxide on antibacterial activities of Canadian honey by Brudzynski K1.(PubMed)
(311) Streptomyces sp. JS520 produces exceptionally high quantities of undecylprodigiosin with antibacterial, antioxidative, and UV-protective properties by Stankovic N1, Radulovic V, Petkovic M, Vuckovic I, Jadranin M, Vasiljevic B, Nikodinovic-Runic J.(PubMed)
(312) Antimicrobial polyurethane thermosets based on undecylenic acid: synthesis and evaluation.by Lluch C1, Esteve-Zarzoso B, Bordons A, Lligadas G, Ronda JC, Galià M, Cádiz V.(PubMed)
(313) Allergic contact dermatitis from undecylenic acid in a commercial antifungal nail solution by Anguita JL1, Escutia B, Marí JI, Rodríguez M, De La Cuadra J, Aliaga A.(PubMed)
(314) Undecylenic acid and fungous infections by Landau JW.(PubMed)
(315) Undecylenic acid inhibits morphogenesis of Candida albicansby McLain N1, Ascanio R, Baker C, Strohaver RA, Dolan JW.(PubMed)
(316) [Inhibition of Candida mycelia growth by a medium chain fatty acids, capric acid in vitro and its therapeutic efficacy in murine oral candidiasis].[Article in Japanese]by Takahashi M1, Inoue S, Hayama K, Ninomiya K, Abe S.(PubMed)
(317) [Effects of inhibitory activity on mycelial growth of Candida albicans and therapy for murine oral candidiasis by the combined use of terpinen-4-ol and a middle-chain fatty acid, capric acid].[Article in Japanese]by Ninomiya K1, Hayama K, Ishijima S, Takahashi M, Kurihara J, Abe S.(PubMed)
(318) In vitro and in vivo immune-stimulating effects of a new standardized Echinacea angustifolia root extract (Polinacea) by Morazzoni P1, Cristoni A, Di Pierro F, Avanzini C, Ravarino D, Stornello S, Zucca M, Musso T.(PubMed)
(319) Immune enhancing effects of Echinacea purpurea root extract by reducing regulatory T cell number and function by Kim HR, Oh SK, Lim W, Lee HK, Moon BI, Seoh JY.(PubMed)
(320) Applications of the phytomedicine Echinacea purpurea (Purple Coneflower) in infectious diseases. by Hudson JB1.(PubMed)
(321) Anethole, a potential antimicrobial synergist, converts a fungistatic dodecanol to a fungicidal agent Fujita K1, Fujita T, Kubo I.(PubMed)
(322) Polygodial, an antifungal potentiator by Kubo I1, Taniguchi M.(PubMed)
(323) Enterococci from piglets--probiotic properties and responsiveness to natural antibacterial substances by Strompfová V1, Lauková A.(PubMed)
(324) Dietary supplementation with two Lamiaceae herbs-(oregano and sage) modulates innate immunity parameters in Lumbricus terrestris by Vattem DA1, Lester C, Deleon R, Jamison B, Maitin V.(PubMed)
(325) Oregano Oil for Candida(New health guide)(326) In vitro activity of origanum vulgare essential oil against candida species by Cleff MB1, Meinerz AR, Xavier M, Schuch LF, Schuch LF, Araújo Meireles MC, Alves Rodrigues MR, de Mello JR. (PubMed)
(327) Augmented humoral immune response and decreased cell-mediated immunity by Aloe vera in rats. by Halder S1, Mehta AK, Mediratta PK.(PubMed)
(328) Antimicrobial activity of preparation Bioaron C by Gawron-Gzella A, Michalak A, Kędzia A.(PubMed)
(329) Antimicrobial activity of plant extracts on Candida albicans: an in vitro study by Doddanna SJ1, Patel S, Sundarrao MA, Veerabhadrappa RS. (PubMed)
(330) Antifungals: Aloe Vera(The candida diet)
(331) The Influence of Tea Tree Oil (Melaleuca alternifolia) on Fluconazole Activity against Fluconazole-Resistant Candida albicans Strains by Mertas A1, Garbusińska A1, Szliszka E1, Jureczko A1, Kowalska M1, Król W1.(PubMed)
(332) In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species by Mondello F1, De Bernardis F, Girolamo A, Cassone A, Salvatore G.(PubMed)
(333) [The effect of tannic acid on the colonization of Candida in tissue conditioning material].
[Article in Japanese]by Kubota K.(PubMed)(334) [The effect of tannic acid on the attachment of Candida albicans to plate denture lining material].
[Article in Japanese]by Tanaka T.(PubMed)
(335) Who Gets Yeast Infections? (Things for ladies)(336) Evaluation of Phytochemical Screening and Anti Inflammatory Activity of Leaves and Stem of Mikania scandens (L.) Wild by Banerjee S1, Chanda A1, Adhikari A2, Das A2, Biswas S3.(PubMed)
(337) The effect of oxalate on gluconeogenesis by isolated chicken hepatocytes. Increased sensitivity to inhibition as a result of biotin deficiency by Bannister DW, O'Neill IE. (PubMed)
(338) Growth of Candida albicans in a minimal synthetic medium without biotin. by Vidotto V1, Pugliese A, Gioannini P.(PubMed)
(339) Candida Infestation and BiotinWritten by Sean Brookwood Published on September 22, 2013
(340) Improved growth and viability of lactobacilli in the presence of Bacillus subtilis (natto), catalase, or subtilisin by Hosoi T1, Ametani A, Kiuchi K, Kaminogawa S.(PubMed)
(Oxidative stress responses in the human fungal pathogen, Candidaalbicans by Dantas Ada S1, Day A2, Ikeh M3, Kos I4, Achan B5, Quinn J6.(PubMed)
(341) Candida Diets: Part II: Hydrogen Peroxide Written by Jeff McCombs(342) Glutamine supplementation for young infants with severe gastrointestinal disease. by Brown JV1, Moe-Byrne T, McGuire W.(PubMed)
Monday, 3 July 2023
#Sulforaphane (Isothiocyanates) Inhibits the Proteins Associated with Fat-Deposit in Obesity, Researchers Say
Kyle J. Norton
Dithiolthiones, a bioactive ingredient found in cruciferous vegetables may have an effect on reducing the risk of obesity in chronic consumption, some scientists suggested.
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
Obesity is a medical condition caused by excess body fat accumulated over time.
And, overweight is a condition of excess body weight relative to the height.
According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity.
According to the statistic, 68% of the American population is either overweight or obese.
Some researchers suggested that the prevalent and widespread obesity in the Western world not only increased the burden of health care and economic cost but also induce a reduced quality of life for adults due to chronic ailments.
In the comparison of the obesity rate today and 50 years ago, the Centers for Disease Control statistic showed that the obesity rate has skyrocketed by more than 185 percent among American adults over the last 50 years, and the rate of extreme obesity among children have tripled during the same time period.
These results clearly suggested that the adults today must have something different in their daily activities that contributes to these significant changes.
Some researchers suggested that lack of exercise may be one the most prevalent risk factor which induces the onset of obesity.
Dr. Petri, the lead scientist in the examine the role of physical activity and exercise in obesity and weight said, "Obesity is caused by a consistent decline in daily energy expenditure is not supported either by objective measures of energy expenditure or physiological theory of weight gain alone. However, since voluntary exercise is the most important discretionary component of total daily energy expenditure, it can affect energy balance".
This conclusion indicated that lack of exercise and over-nutrient consumption work together to facilitate the onset of overweight and obesity.
In the concern of obesity widespread in the American population, researchers examine the anti-obesity effect of sulforaphane in the animal model. C57BL/6N mice in the study. were fed a normal diet (ND), HFD, or HFD plus 0.1% sulforaphane (SFN) for 6 weeks.
According to the food efficiency ratios compared to untreated control, the sulforaphane treatment group showed a lower body weight. SFN attenuated HFD-induced visceral adiposity, adipocyte hypertrophy associated with increasing the store of fat within the abdominal cavity, and fat accumulation in the liver.
Futhermore, Serum total cholesterol and leptin, and liver triglyceride levels were lower in HFD-SFN-fed mice than in HFD-fed mice.
The efficacy of SFN in the anti-fat deposit was attributed to the decreased expression of a protein which plays a critical in reducing triglyceride level and regulating the energy homeostasis and increased adiponectin expression in the modulation of glucose and fatty acid oxidation.
Taking foods containing sulforaphane may be effective in managing weight loss for obese patients accompanied by a change of lifestyle with more vegetables and fruits into a diet.
Futhermore, in a highly palatable (HP) diet male Wistar rats, injection of sulforaphane (SFN, 1 mg kg⁻¹, 4 months treatment)exerted some beneficial effects on obesity and insulin resistance.
Moreover, glucose tolerance was lower in the HP diet groups, especially in the HP group treated with SFN. Except for the liver triacylglycerols.
Moreover, SFN at the specific dose was found to accentuate glucose intolerance and affect the GLUT3 protein in facilitating the transport of glucose across the plasma membranes of mammalian cells in the cerebral cortex and hypothalamus in the HP diet group treated with SFN.
Taken altogether, plant base sulforaphane may be considered a bioactive compound for the prevention and treatment of obesity with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice by Choi KM1, Lee YS1, Kim W1, Kim SJ2, Shin KO1, Yu JY3, Lee MK1, Lee YM1, Hong JT1, Yun YP1, Yoo HS4. (PubMed)
(2) Chronic sulforaphane oral treatment accentuates blood glucose impairment and may affect GLUT3 expression in the cerebral cortex and hypothalamus of rats fed with a highly palatable diet by Souza CG1, Riboldi BP, Hansen F, Moreira JD, Souza DG, de Assis AM, Brum LM, Perry ML, Souza DO. (PubMed)
(3) Sulforaphane induced adipolysis via hormone-sensitive lipase activation, regulated by AMPK signaling pathway by Lee JH1, Moon MH, Jeong JK, Park YG, Lee YJ, Seol JW, Park SY. (PubMed)
(4) The role of physical activity and exercise in obesity and weight management: Time for critical appraisal by PetriWiklund. (Research Gate)
Dithiolthiones, a bioactive ingredient found in cruciferous vegetables may have an effect on reducing the risk of obesity in chronic consumption, some scientists suggested.
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
Obesity is a medical condition caused by excess body fat accumulated over time.
And, overweight is a condition of excess body weight relative to the height.
According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity.
According to the statistic, 68% of the American population is either overweight or obese.
Some researchers suggested that the prevalent and widespread obesity in the Western world not only increased the burden of health care and economic cost but also induce a reduced quality of life for adults due to chronic ailments.
In the comparison of the obesity rate today and 50 years ago, the Centers for Disease Control statistic showed that the obesity rate has skyrocketed by more than 185 percent among American adults over the last 50 years, and the rate of extreme obesity among children have tripled during the same time period.
These results clearly suggested that the adults today must have something different in their daily activities that contributes to these significant changes.
Some researchers suggested that lack of exercise may be one the most prevalent risk factor which induces the onset of obesity.
Dr. Petri, the lead scientist in the examine the role of physical activity and exercise in obesity and weight said, "Obesity is caused by a consistent decline in daily energy expenditure is not supported either by objective measures of energy expenditure or physiological theory of weight gain alone. However, since voluntary exercise is the most important discretionary component of total daily energy expenditure, it can affect energy balance".
This conclusion indicated that lack of exercise and over-nutrient consumption work together to facilitate the onset of overweight and obesity.
In the concern of obesity widespread in the American population, researchers examine the anti-obesity effect of sulforaphane in the animal model. C57BL/6N mice in the study. were fed a normal diet (ND), HFD, or HFD plus 0.1% sulforaphane (SFN) for 6 weeks.
According to the food efficiency ratios compared to untreated control, the sulforaphane treatment group showed a lower body weight. SFN attenuated HFD-induced visceral adiposity, adipocyte hypertrophy associated with increasing the store of fat within the abdominal cavity, and fat accumulation in the liver.
Futhermore, Serum total cholesterol and leptin, and liver triglyceride levels were lower in HFD-SFN-fed mice than in HFD-fed mice.
The efficacy of SFN in the anti-fat deposit was attributed to the decreased expression of a protein which plays a critical in reducing triglyceride level and regulating the energy homeostasis and increased adiponectin expression in the modulation of glucose and fatty acid oxidation.
Taking foods containing sulforaphane may be effective in managing weight loss for obese patients accompanied by a change of lifestyle with more vegetables and fruits into a diet.
Futhermore, in a highly palatable (HP) diet male Wistar rats, injection of sulforaphane (SFN, 1 mg kg⁻¹, 4 months treatment)exerted some beneficial effects on obesity and insulin resistance.
Moreover, glucose tolerance was lower in the HP diet groups, especially in the HP group treated with SFN. Except for the liver triacylglycerols.
Moreover, SFN at the specific dose was found to accentuate glucose intolerance and affect the GLUT3 protein in facilitating the transport of glucose across the plasma membranes of mammalian cells in the cerebral cortex and hypothalamus in the HP diet group treated with SFN.
Taken altogether, plant base sulforaphane may be considered a bioactive compound for the prevention and treatment of obesity with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice by Choi KM1, Lee YS1, Kim W1, Kim SJ2, Shin KO1, Yu JY3, Lee MK1, Lee YM1, Hong JT1, Yun YP1, Yoo HS4. (PubMed)
(2) Chronic sulforaphane oral treatment accentuates blood glucose impairment and may affect GLUT3 expression in the cerebral cortex and hypothalamus of rats fed with a highly palatable diet by Souza CG1, Riboldi BP, Hansen F, Moreira JD, Souza DG, de Assis AM, Brum LM, Perry ML, Souza DO. (PubMed)
(3) Sulforaphane induced adipolysis via hormone-sensitive lipase activation, regulated by AMPK signaling pathway by Lee JH1, Moon MH, Jeong JK, Park YG, Lee YJ, Seol JW, Park SY. (PubMed)
(4) The role of physical activity and exercise in obesity and weight management: Time for critical appraisal by PetriWiklund. (Research Gate)
The #ColonHealth Enhancing Herbal Medicines, According to Studies
Kyle J. Norton
The western diet contains high saturated fat, trans fat, and other harmful substances such as sugar, caffeine, pesticides, and addictive substances, and less in fruits and vegetables.
Environment natural occurring compounds such as lead; mercury; radon, formaldehyde; benzene; and cadmium. and man-made compounds such as BPA phthalates and pesticides accumulated without notices by the host also can cause endocrine disruption and organs failure.
Toxins can also be accumulated due to long-term intake of certain conventional medicine such as Amiodarone (Cordarone), antibiotics, diuresis,.... and beta-blockers, anti-depressants, and cytotoxic drugs or cytostatics used for the treatment of cancers.
These types of harmful substances are toxic. In order to protect and maintain normal function of our body, every day, our body's detoxifying organs must work overtime to get rid of them.
However, if they fail, these toxins may cause a disruption of hormone production, damage of our body's detoxification organs and weakening of our immune system, resulting in hormone imbalance and development of chronic illness.
Herbal medicine has a strong effect on colon cleansing, including
1. Flaxseed
Flaxseed containing high amounts of omega 3 fatty acid, fiber, and lignan not only helps in controlling cholesterol in the bloodstream and provides essential nutrition to our body, but its fiber also softens the stool and promotes bowel movements for the relief of constipation by removing all toxins accumulated in the colon.
According to a study by the Mercer University, Atlanta, flax seed with abundant Omega-3 fatty acids, such as α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), exerted a significant effect in protect the colon health through heightening colonic free fatty acid receptor 4 (FFAR4) and actin expression with function in mobility and contraction of cells during cell division, and reducing expression of the pro-inflammatory cytokine TNF-α compared to animals fed control diets(1).
Dr. Gomides AF, at the Federal University of Juiz de Fora in the investigation of the effect in
defatted flaxseed meal and risk precancerous colon lesions in C57BL/6 mice said, 'The rats consuming defatted flaxseed meals showed lesions with lower multiplicity and a reduced incidence of lesions".
Some researchers also suggested that adding a portion of flaxseed (Linum usitatissimum L.) and its total non-digestible fraction may have a strong effect in the inhibited azoxymethane (AOM)-induced colon (toxicity) cancer in Sprague Dawley rats(3).
2. Psyllium Psyllium
Psyllium contains about 70% soluble fiber and 30% insoluble fiber.
Besides having a proven record in Chinese medicine in treating high levels of cholesterol, its fiber portion also is used to treat constipation by softening stools and easing bowel movements.
According to the joint study led by the Institute for Genomics and Multiscale Biology, the investigation of interactions between dietary ingredients, nutrients, and the microbiota in specific pathogen-free (SPF) and germ-free (GF) mice showed that application of all tested fibers reduces the severity of colitis in SPF mice, but not in GF mice or mice were given antibiotics.
Compared to other tested fiber, psyllium fiber reduced the severity of colitis effects through improvement of microbiota-dependent and microbiota-independent mechanisms.
If used combinatorial perturbations to dietary casein protein, psyllium fiber exerted a significant effect in reduced intestinal permeability, gut microbial density, and development of intestinal inflammation.
Truly, higher intakes of dietary fiber are linked to improvement of gut health.
Some researchers also suggested, "fiber undergoes partial or total fermentation in the distal small bowel and colon leading to the production of short-chain fatty acids and gas, thereby affecting gastrointestinal function and sensation"(5).
3. Bentonite clay or liquid clay
Bentonite clay is a natural clay that comes from volcanic ash.
Taken internally, the adsorbent action of bentonite eliminates and removes toxic material from the intestine.
According to the study by Shiraz University of Medical Sciences, bentonite clay may be used as a detoxifying agent because of its poly-cationic nature(6),
T-2 is a trichothecene mycotoxin, injection of bentonite for 2 weeks before T-2 toxicosis, showed a significant increase in fecal excretion of this toxin(6)
Furthermore, bentonite may be used in humans as a dietary intervention to prevent and cure aflatoxin toxicity. if it does not affect the serum concentrations of important vitamins and nutrient minerals in humans(6).
4. Buckthorn Bark
Buckthorn bark is native to Europe and parts of western Asia.
The herb contains anthraquinones that stimulate intestinal movement by easing water to the intestines. These results suggested that buckthorn bark may have a strong impact in softened stool and removed toxins accumulated in the intestine.
In the article posted at the Whole Health Chicago, the author wrote, "(anthraquinones) ease constipation. The compounds in buckthorn bark increase the colon’s ability to spontaneously contract. They also reduce water absorption by the intestines, which means more liquid is left in the colon. This produces larger volume and softer stools, which in turn eases constipation"(7)
5. Cascara sagrada
Cascara sagrada is known to tone the relaxed intestinal muscles in the digestive system.
Intake of cascara sagrada promotes the digestive process in the prevention of digestive dysfunction such as chronic constipation.
In the study to assess aloe-emodin anthrone (AEA), the major compound found in cascara sagrada in the rat colonic mucosa using a Using-type chamber, the researcher showed that AEA is effective in the absorption of enhancers such as pyrilamine, and histamine H(1) receptor antagonist and ketotifen without damage of the colon membrane and causing cytotoxicity(8).
Dr. Kai M, the lead scientist, after taking into account of other co and confounders, said, " AEA stimulates mast cells within the colonic mucosa to release histamine, which probably binds to the H(1) receptor. The intracellular PKC route activated by H(1) receptor activation enhances the permeability of water-soluble and poorly permeable drugs via the opening of tight junctions in rat colonic membrane"(8).
Finally, intake of herbal supplements should be taken with extreme care as acute liver toxicity has been reported in a number of cases. Please consult with your herbalist before applying.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Fish oil and flax seed oil supplemented diets increase FFAR4 expression in the rat colon by Cheshmehkani A#1, Senatorov IS#1, Kandi P1, Singh M1, Britt A1, Hayslett R1, Moniri NH(PubMed)
(2) Use of defatted flaxseed meal reduces precancerous colon lesions in C57BL/6 mice by Gomides AF1, Paula SO, Rosa DD, Oliveira LL, Comastri DS, Peluzio Mdo C(PubMed)
(3) Flaxseed (Linum usitatissimum L.) and its total non-digestible fraction influence the expression of genes involved in azoxymethane-induced colon cancer in rats by Hernández-Salazar M1, Guevara-González RG, Cruz-Hernández A, Guevara-Olvera L, Bello-Pérez LA, Castaño-Tostado E, Loarca-Piña G(PubMed).
(4) Interactions Between Diet and the Intestinal Microbiota Alter Intestinal Permeability and Colitis Severity in Mice by Llewellyn SR1, Britton GJ1, Contijoch EJ1, Vennaro OH1, Mortha A2, Colombel JF3, Grinspan A3, Clemente JC1, Merad M4, Faith JJ(PubMed)
(5) Fiber and functional gastrointestinal disorders by Eswaran S1, Muir J, Chey WD(PubMed)
(6) Bentonite Clay as a Natural Remedy: A Brief Review by Maryam MOOSAVI(PMC)
(7) Buckthorn Bark, Whole Health Chicago
(8) Permeation-enhancing effect of aloe-emodin anthrone on water-soluble and poorly permeable compounds in rat colonic mucosa by Kai M1, Hayashi K, Kaida I, Aki H, Yamamoto M(PubMed)
The western diet contains high saturated fat, trans fat, and other harmful substances such as sugar, caffeine, pesticides, and addictive substances, and less in fruits and vegetables.
Environment natural occurring compounds such as lead; mercury; radon, formaldehyde; benzene; and cadmium. and man-made compounds such as BPA phthalates and pesticides accumulated without notices by the host also can cause endocrine disruption and organs failure.
Toxins can also be accumulated due to long-term intake of certain conventional medicine such as Amiodarone (Cordarone), antibiotics, diuresis,.... and beta-blockers, anti-depressants, and cytotoxic drugs or cytostatics used for the treatment of cancers.
These types of harmful substances are toxic. In order to protect and maintain normal function of our body, every day, our body's detoxifying organs must work overtime to get rid of them.
However, if they fail, these toxins may cause a disruption of hormone production, damage of our body's detoxification organs and weakening of our immune system, resulting in hormone imbalance and development of chronic illness.
Herbal medicine has a strong effect on colon cleansing, including
1. Flaxseed
Flaxseed containing high amounts of omega 3 fatty acid, fiber, and lignan not only helps in controlling cholesterol in the bloodstream and provides essential nutrition to our body, but its fiber also softens the stool and promotes bowel movements for the relief of constipation by removing all toxins accumulated in the colon.
According to a study by the Mercer University, Atlanta, flax seed with abundant Omega-3 fatty acids, such as α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), exerted a significant effect in protect the colon health through heightening colonic free fatty acid receptor 4 (FFAR4) and actin expression with function in mobility and contraction of cells during cell division, and reducing expression of the pro-inflammatory cytokine TNF-α compared to animals fed control diets(1).
Dr. Gomides AF, at the Federal University of Juiz de Fora in the investigation of the effect in
defatted flaxseed meal and risk precancerous colon lesions in C57BL/6 mice said, 'The rats consuming defatted flaxseed meals showed lesions with lower multiplicity and a reduced incidence of lesions".
Some researchers also suggested that adding a portion of flaxseed (Linum usitatissimum L.) and its total non-digestible fraction may have a strong effect in the inhibited azoxymethane (AOM)-induced colon (toxicity) cancer in Sprague Dawley rats(3).
2. Psyllium Psyllium
Psyllium contains about 70% soluble fiber and 30% insoluble fiber.
Besides having a proven record in Chinese medicine in treating high levels of cholesterol, its fiber portion also is used to treat constipation by softening stools and easing bowel movements.
According to the joint study led by the Institute for Genomics and Multiscale Biology, the investigation of interactions between dietary ingredients, nutrients, and the microbiota in specific pathogen-free (SPF) and germ-free (GF) mice showed that application of all tested fibers reduces the severity of colitis in SPF mice, but not in GF mice or mice were given antibiotics.
Compared to other tested fiber, psyllium fiber reduced the severity of colitis effects through improvement of microbiota-dependent and microbiota-independent mechanisms.
If used combinatorial perturbations to dietary casein protein, psyllium fiber exerted a significant effect in reduced intestinal permeability, gut microbial density, and development of intestinal inflammation.
Truly, higher intakes of dietary fiber are linked to improvement of gut health.
Some researchers also suggested, "fiber undergoes partial or total fermentation in the distal small bowel and colon leading to the production of short-chain fatty acids and gas, thereby affecting gastrointestinal function and sensation"(5).
3. Bentonite clay or liquid clay
Bentonite clay is a natural clay that comes from volcanic ash.
Taken internally, the adsorbent action of bentonite eliminates and removes toxic material from the intestine.
According to the study by Shiraz University of Medical Sciences, bentonite clay may be used as a detoxifying agent because of its poly-cationic nature(6),
T-2 is a trichothecene mycotoxin, injection of bentonite for 2 weeks before T-2 toxicosis, showed a significant increase in fecal excretion of this toxin(6)
Furthermore, bentonite may be used in humans as a dietary intervention to prevent and cure aflatoxin toxicity. if it does not affect the serum concentrations of important vitamins and nutrient minerals in humans(6).
4. Buckthorn Bark
Buckthorn bark is native to Europe and parts of western Asia.
The herb contains anthraquinones that stimulate intestinal movement by easing water to the intestines. These results suggested that buckthorn bark may have a strong impact in softened stool and removed toxins accumulated in the intestine.
In the article posted at the Whole Health Chicago, the author wrote, "(anthraquinones) ease constipation. The compounds in buckthorn bark increase the colon’s ability to spontaneously contract. They also reduce water absorption by the intestines, which means more liquid is left in the colon. This produces larger volume and softer stools, which in turn eases constipation"(7)
5. Cascara sagrada
Cascara sagrada is known to tone the relaxed intestinal muscles in the digestive system.
Intake of cascara sagrada promotes the digestive process in the prevention of digestive dysfunction such as chronic constipation.
In the study to assess aloe-emodin anthrone (AEA), the major compound found in cascara sagrada in the rat colonic mucosa using a Using-type chamber, the researcher showed that AEA is effective in the absorption of enhancers such as pyrilamine, and histamine H(1) receptor antagonist and ketotifen without damage of the colon membrane and causing cytotoxicity(8).
Dr. Kai M, the lead scientist, after taking into account of other co and confounders, said, " AEA stimulates mast cells within the colonic mucosa to release histamine, which probably binds to the H(1) receptor. The intracellular PKC route activated by H(1) receptor activation enhances the permeability of water-soluble and poorly permeable drugs via the opening of tight junctions in rat colonic membrane"(8).
Finally, intake of herbal supplements should be taken with extreme care as acute liver toxicity has been reported in a number of cases. Please consult with your herbalist before applying.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Fish oil and flax seed oil supplemented diets increase FFAR4 expression in the rat colon by Cheshmehkani A#1, Senatorov IS#1, Kandi P1, Singh M1, Britt A1, Hayslett R1, Moniri NH(PubMed)
(2) Use of defatted flaxseed meal reduces precancerous colon lesions in C57BL/6 mice by Gomides AF1, Paula SO, Rosa DD, Oliveira LL, Comastri DS, Peluzio Mdo C(PubMed)
(3) Flaxseed (Linum usitatissimum L.) and its total non-digestible fraction influence the expression of genes involved in azoxymethane-induced colon cancer in rats by Hernández-Salazar M1, Guevara-González RG, Cruz-Hernández A, Guevara-Olvera L, Bello-Pérez LA, Castaño-Tostado E, Loarca-Piña G(PubMed).
(4) Interactions Between Diet and the Intestinal Microbiota Alter Intestinal Permeability and Colitis Severity in Mice by Llewellyn SR1, Britton GJ1, Contijoch EJ1, Vennaro OH1, Mortha A2, Colombel JF3, Grinspan A3, Clemente JC1, Merad M4, Faith JJ(PubMed)
(5) Fiber and functional gastrointestinal disorders by Eswaran S1, Muir J, Chey WD(PubMed)
(6) Bentonite Clay as a Natural Remedy: A Brief Review by Maryam MOOSAVI(PMC)
(7) Buckthorn Bark, Whole Health Chicago
(8) Permeation-enhancing effect of aloe-emodin anthrone on water-soluble and poorly permeable compounds in rat colonic mucosa by Kai M1, Hayashi K, Kaida I, Aki H, Yamamoto M(PubMed)
#Healthyfood #Garlic Inhibits the Risk of #BreastCancer by Decreasing Proliferation and Inducing Apoptosis of #Cancer Cells, Scientists Reveal
Kyle J. Norton
The finding of whole food medication by scientists all over the world to replace the single ingredient of Western medicine for the treatment of breast cancer with little or no side effects has been difficult due to no commercial benefits and patent rights to producers.
Breast cancer is a medical and chronic condition characterized by irregular cell growth in the breast tissue.
In most cases, breast cancer (malignant breast neoplasm) starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
There are also rare cases that breast cancer starts in other areas of the breast.
According to statistics, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Depending on the stage of cancer, women in the very early stage (increased risk of breast cancer) may only experience rusting at the nipple, bloody nipple drainage, and a retracted, flattened nipple, particularly in those symptoms that do not go away in 2 weeks.
In the early stage of breast cancer, the tumor is smaller than the approximate size of a peanut (2 centimeters or smaller) and localized.
The survival rate of women diagnosed at this early stage is 100%.
In the breast cancer stage, according to the American Cancer Society, any of the following unusual changes in the breast can be a symptom of breast cancer such as swelling of all or part of the breast, skin irritation, or dimpling. breast pain, nipple pain, or the nipple turning inward. redness, scaliness, or thickening of the nipple or breast skin.
Therefore, regardless of breast cancer risk, self-examination is one of the best methods to detect early breast cancer. All women should be themselves looking at and feeling each breast for possible lumps, distortions, or swelling monthly,
Some researchers suggested that women with alternated genes and a family history of breast cancer might be required to have their mammograms taken annually.
Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia.
The food or herb has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
According to the study, administration of fresh Garlic Extract only exerted a significant effect in the inhibited colon and gastric cancer, but also stimulated cancer cell cycle arrest and alternated the morphology of MCF7 breast cancer cells.
In MCF7 human breast cancer cells, garlic constituent diallyl trisulfide has highly effective antitumor effects by suppressing the viability of cultured MCF-7 and MCF-12a cells, through decreased percent of cells in G(2)/M and induced apoptotic cell death.
According to the study by 201 South University Street, diallyl trisulfide, inhibited the expression of MDA-MB-231 and MCF-7 breast cancer cells, regardless of the state of estrogen in the tumors.
In a total of 285 women (aged 25-65 years old) newly diagnosed with histopathologically confirmed breast cancer, dietary Allium Vegetables have a negative association between the consumption of raw onion and the risk of breast cancer.
Dr. Roy N., the lead author at the Kerala Agricultural University, said, "Docking studies and ADMET evaluation revealed twelve compounds (isolated from garlic) to be active against the targets(breast cancer cell lines). All the compounds displayed highly negative dock scores which indicated good interactions".
These results suggested that the effectiveness of garlic in reduced risk and treatment of breast cancer is probably due to the existence of many phytochemicals found in the herb.
Adding garlic intake to your daily diet can ameliorate the risk of breast cancer substantially.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Fresh Garlic Extract Induces Growth Arrest and Morphological Differentiation of MCF7 Breast Cancer Cells by Modem S1, Dicarlo SE, Reddy TR. (PubMed)
(2) Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells by Malki A1, El-Saadani M, Sultan AS.(PubMed)
(3) Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells by Kiesel VA1, Stan SD2. (PubMed)
The finding of whole food medication by scientists all over the world to replace the single ingredient of Western medicine for the treatment of breast cancer with little or no side effects has been difficult due to no commercial benefits and patent rights to producers.
Breast cancer is a medical and chronic condition characterized by irregular cell growth in the breast tissue.
In most cases, breast cancer (malignant breast neoplasm) starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
There are also rare cases that breast cancer starts in other areas of the breast.
According to statistics, in 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Depending on the stage of cancer, women in the very early stage (increased risk of breast cancer) may only experience rusting at the nipple, bloody nipple drainage, and a retracted, flattened nipple, particularly in those symptoms that do not go away in 2 weeks.
In the early stage of breast cancer, the tumor is smaller than the approximate size of a peanut (2 centimeters or smaller) and localized.
The survival rate of women diagnosed at this early stage is 100%.
In the breast cancer stage, according to the American Cancer Society, any of the following unusual changes in the breast can be a symptom of breast cancer such as swelling of all or part of the breast, skin irritation, or dimpling. breast pain, nipple pain, or the nipple turning inward. redness, scaliness, or thickening of the nipple or breast skin.
Therefore, regardless of breast cancer risk, self-examination is one of the best methods to detect early breast cancer. All women should be themselves looking at and feeling each breast for possible lumps, distortions, or swelling monthly,
Some researchers suggested that women with alternated genes and a family history of breast cancer might be required to have their mammograms taken annually.
Garlic (Allium sativum) is a species in the onion genus, belonging to the family Amaryllidaceae, native to central Asia.
The food or herb has been used popularly in traditional and Chinese medicine in treating the common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
According to the study, administration of fresh Garlic Extract only exerted a significant effect in the inhibited colon and gastric cancer, but also stimulated cancer cell cycle arrest and alternated the morphology of MCF7 breast cancer cells.
In MCF7 human breast cancer cells, garlic constituent diallyl trisulfide has highly effective antitumor effects by suppressing the viability of cultured MCF-7 and MCF-12a cells, through decreased percent of cells in G(2)/M and induced apoptotic cell death.
According to the study by 201 South University Street, diallyl trisulfide, inhibited the expression of MDA-MB-231 and MCF-7 breast cancer cells, regardless of the state of estrogen in the tumors.
In a total of 285 women (aged 25-65 years old) newly diagnosed with histopathologically confirmed breast cancer, dietary Allium Vegetables have a negative association between the consumption of raw onion and the risk of breast cancer.
Dr. Roy N., the lead author at the Kerala Agricultural University, said, "Docking studies and ADMET evaluation revealed twelve compounds (isolated from garlic) to be active against the targets(breast cancer cell lines). All the compounds displayed highly negative dock scores which indicated good interactions".
These results suggested that the effectiveness of garlic in reduced risk and treatment of breast cancer is probably due to the existence of many phytochemicals found in the herb.
Adding garlic intake to your daily diet can ameliorate the risk of breast cancer substantially.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Fresh Garlic Extract Induces Growth Arrest and Morphological Differentiation of MCF7 Breast Cancer Cells by Modem S1, Dicarlo SE, Reddy TR. (PubMed)
(2) Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells by Malki A1, El-Saadani M, Sultan AS.(PubMed)
(3) Diallyl trisulfide, a chemopreventive agent from Allium vegetables, inhibits alpha-secretases in breast cancer cells by Kiesel VA1, Stan SD2. (PubMed)
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