Monday, 3 July 2023

#BeetJuice in the Promotion of #BrainHealth Through Its #Antixodant Activities, Researchers Say

Kyle J. Norton

Scientists may have found a whole plant food juice, namely beet or beetroot juice exerted a neuroprotective effect and promoted brain health, some scientists suggested.

Beet, best known as the beetroot or garden beet, belongings to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.

Brain health is a broader term of improved function of the normal brain and protected the brain against damage and degeneration as we age.

According to general belief, including daily intake of necessary nutrients together with participation in different mental, social and physical activities may play an essential role in the maintenance of healthy brain and improvement of brain function.

Some researchers suggested that consumption of a Western Diet (WD) high in saturated fat and added sugars is associated to reduced cognitive function, particularly the mnemonic processes due to the diet in promotion of increased production of endotoxin secreted by certain gram-negative bacteria, that have a strong impact in induced neuroinflammation and cognitive dysfunction(3).

People involved in physical exercise may have a decreased risk of developing cognitive impairment, particularly, in the aging population, as exercise improved blood flow to the brain.

Neuroprotection is an action used to ensure the brain to perform normal function against nerve cells damage, degeneration in inducing impairment.

The MVP Samaj's College of Pharmacy, in the study of the effect of beet juice and brain health, suggested that ethnic extract of beet used in experimental animals shows a significant effect in increased motor function at 200, and 300 mg/kg, in dose depending manner.

Physically, the oral administrated animal also showed a strong improvement of the intensity of muscular rigidity, duration of catalepsy, akinesia, the number of tremors, locomotor activity and grip strength.

The efficacy of the extract in the contribution to brain health may due to phytochemicals of beet juice in restoring the defensive antioxidant enzymes in the brain against the level of lipid peroxidation (LPO), a leading cause of neurodegeneration.

More interestingly, Betalains, major phytochemicals isolated from whole plant beetroot in the investigation of oxidative stress demonstrated an extraordinary neuroprotective effect in inhibited overexpression of free radicals in initiated oxidative processes that contribute to the early onset of several degenerative diseases.

Further examination of betanin bioavailability in four volunteers with consumption of 300 mL of red beet juice, containing 120 mg of the antioxidant, researchers found that the phytochemical shows protection against certain oxidative stress-related disorders in humans after being absorbed from the gut and identified in urine between 2-4 h.

Dr. Kanner J, the lead author said, "Antioxidant nutrients from fruits and vegetables are believed to be a class of compounds that exert their effects in humans by preventing oxidative processes which contribute to the onset of several degenerative diseases".

Collectively, Whole food beetroot or beet juice may be used as a therapeutic agent for the prevention of the early onset and treatment of neurodegenerative disease through protection of neurons against oxidation.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Neuroprotective potential of Beta vulgaris L. in Parkinson's disease by Nade VS1, Kawale LA1, Zambre SS1, Kapure AB1. (PubMed)
(2) Betalains--a new class of dietary cationized antioxidants by Kanner J1, Harel S, Granit R.(PubMed)
(3) Gut to Brain Dysbiosis: Mechanisms Linking Western Diet Consumption, the Microbiome, and Cognitive Impairment by Emily E. Noble,1 Ted M. Hsu,1,2 and Scott E. Kanoski(PMC)

#Herbal #Butterbur #Extract Exerts A Significant Antioxidant Activity Against Overexpression of FreeRadicals, Researchers Reveal

Kyle J. Norton

Herbal Butterbur may be the potential target to extract a single ingredient for the treatment of oxidative stress, some scientists suggested.

Oxidative stress is either caused by overexpression free radicals compared to levels of antioxidant or suppression of the levels of antioxidant enzymes in the host body, compared to the expression of free radicals.

The imbalanced ratio of free radical and antioxidant enzymes produced by the host that counter the overexpression of free radicals has been found to facilitate the early onset of numbers of chronic ailments, such as cancers.

Free radicals are naturally produced from daily normal essential metabolic processes in the human body. However, some external sources such as exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals can also increase the expression of free radicals in the body.

Free radicals are unstable molecules with the unpaired electron in the outer ring and ready to donate or steal an electron from another molecule, leading to the chain reaction until they are stopped by the presence of the antioxidants or their outer ring are paired.

Overexpression of free radical chain reactive in the human body has been known to induce oxidative stress, causing damage to the cells, proteins, and alternation of cell DNA. In this case, the application of an external source of antioxidants such as synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole may be helpful to restore the balance of these 2 types of molecule.

Hydroxyl radical, superoxide anion radical, hydrogen peroxide, oxygen singlet, hypochlorite, nitric oxide radical, and peroxynitrite radical are hight reactive and important free radical associated with many chronic diseases.

Dr. V. Lobo, in the concern of the overexpression of free radicals in the induction of a number of human chronic illnesses, conducted a study to examine the impacts of free radicals, antioxidants and functional foods in human health said In summary, "Free radicals damage contributes to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataract, and cancer. Antioxidants prevent free radical-induced tissue damage by preventing the formation of radicals, scavenging them, or by promoting their decomposition".

(More importantly)" Synthetic antioxidants are recently reported to be dangerous to human health. Thus the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years. In addition to endogenous antioxidant defense systems, the consumption of dietary and plant-derived antioxidants appears to be a suitable alternative. Dietary and other components of plants form a major source of antioxidants".

Butterbur, found in wet, marshy, damp land, including wetland, Riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to the Northern Hemisphere.

The herbal plant has been used in traditional medicine as a pain reliever in the digestive system, including the stomach, bile ducts, duodenum, etc.

The chemical constituents of Butterbur include Petioles, petasitene, and ethylene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.

In the finding of the natural ingredient from the botanical plants which process a significant antioxidant activity without inducing any side effects, researchers at the Second Military Medical University looked into a bioactive compound isolated from the herbal Butterbur.

Four novel bakkenolides - bakkenolide-Ia ( 1), bakkenolide-IIa ( 2), bakkenolide-IIIa ( 3) and bakkenolide-IVa ( 4) - were isolated from the extract of the rhizome of Petasites tricholobus.

All 4 compounds demonstrated neuroprotective activity by reversing the neurons damage exposed to oxygen-glucose deprivation and oxidative insults.

The results of this efficacy were associated with the antioxidant properties of the 4 compounds in inhibiting the oxidative stress caused by the oxygen-glucose deprivation.

The finding indicated that herbal Butterbur not only processed a significant activity in protecting the brain cells against oxidative stress due to overexpression of free radicals but also promoted the production of antioxidant enzymes in the host tissue.

In hyphenated HPLC techniques used to identify the structures and antioxidant activities without prior purification of compounds, researchers found that herbal Butterbur process a number of bioactive compounds, including 5-caffeoylquinic acid (5-CQA), fumarolic acid (FA), 3,5-di-O-caffeoylquinic acid (3,5-DCQA) exert a strong antioxidant free radical scavenging activity.

The greatest radical scavenging capacity was found in the leaf (23.09% of total antioxidant capacity) and root (26.47%) extracts.

The relative radical scavenging portion of quercetin-3-O-(6″-acetyl)-β-glucopyranoside (QAG) was only 3.41% in the leaves and KAG did not show any radical scavenging activity.

These results firmly suggested that herbal Butterbur processes a significant antioxidant property. However, a single ingredient isolated from the herb may express different levels of antioxidants in a dose-depending manner.

Therefore, herbal Butterbur containing a high amount of antioxidant and bioactive compounds free radical scavengers may be considered a functional food for the promotion of antioxidant activity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities by Wang YL, Li RP, Guo ML, Zhang G, Zhang N, Ma YL.(PubMed)
(2) Free radicals, antioxidants and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)

The Anti #OverGrowth of #CandidaAlbicans Functional Foods, Researchers Find

Kyle J. Norton

Candida albicans are members of a large group of microorganism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract.

Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1).

According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased candida resistance toward antifungal drugs.

Overgrowth of candida is associated with some life-threatening and chronic implications, including toxic shock syndrome(TSS), scalded skin syndrome (SSS), irritable bowel syndrome,..... and
Fibromyalgia(a)


The Anti Over Growth of Candida Albicans Foods
1. Apple Cider Vinegar
Apple Cider Vinegar is a type of vinegar made from cider or apple must and has a pale to medium amber color.

Besides it is known for treating obesity(208)(209), the liquid is rich in natural enzymes which aid in digestion,

Apple cider vinegar also balances your body's pH level,

Its high amount of antioxidants also restore the natural balance of healthy bacteria in the gut by creating a perfect environment for those healthy bacteria to grow, while keeping candida in check(207) by enhancing the immune function(210) in regulating the microorganism in the body.


2. Coconut oil
Coconut oil is extracted from the kernel or meat of matured coconut harvested from the coconut palm tree, native to the tropical world.

Coconut oil is one of the most effective antibacterial(including Candida)(211)(213), antioxidant(214), and antiviral(215) agents, used in traditional medicinal remedies for the treatment of benign prostatic hyperplasia(216) and inflammation(217). Caprylic acid, a minor constituent of coconut oil has been demonstrated to inhibit fungal growth(212)(218), both topically and internally.

3. Garlic
Garlic is species of Allium sativum, belongings to the family Alliaceae, used as both food and medicine in many cultures for thousands of years.

Garlic cloves are used as a remedy for infections(219)(220), digestive disorders(221), and fungal infections, including candida(222), due to a large number of anti-fungal properties of sulfur, allicin, alliin, alliinase, and S-allylcysteine.

4. Ginger
Ginger is a species of Zingiber officinale, belongings to the family Zingiberaceae, used as a delicacy, medicine, or spice in many cultures.

The gingerols in ginger increase the motility of the gastrointestinal tract(223) and as an analgesic(224)(226), sedative(225), antipyretic(226), antibacterial(227) and anti-inflammatory(228) properties.

Researcher (Am. J. Applied Sci., 6 (6): 1067-1069, 2009) found that ginger extract with plentiful of gingerol inhibits the growth of many bacteria and fungi, including candida applicants(229)


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca



Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(a) Infectious Disease: Beware Of Some Life-Threatening And Chronic Complications Associated To Over Growth of Candida by Kyle J. Norton
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V1, Barnes AJ. (PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3) Multidrug resistance in the yeast Candida by Prasad R1, Kapoor K.(PubMed)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ1, Kasai M, Francesconi A, Landsman D, Chanock SJ. (PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters by Sanglard D1, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N1, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of the antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH1, Melake NA2, Somily AM3, Zakaria AS4, Baddour MM5, Mahmoud AZ6(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H1, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J1.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H1, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
(Care 2)(209) Changes in anthropometric measurements, body composition, blood pressure, lipid profile, and testosterone in patients participating in a low-energy dietary intervention by Balliett M1, Burke JR. (PubMed)
(210) Apple Cider Vinegar Recipes(Immunology)
(211) Antimicrobial effects of virgin coconut oil and its medium-chain fatty acids on Clostridium difficile by Shilling M1, Matt L, Rubin E, Visitacion MP, Haller NA, Grey SF, Woolverton CJ. (PubMed)
(212) Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms by Huang CB1, Alimova Y, Myers TM, Ebersole JL. (PubMed)
(213) Activity of virgin coconut oil, lauric acid or monolaurin in combination with lactic acid against Staphylococcus aureus by Tangwatcharin P1, Khopaibool P.(PubMed)
(214) Antioxidant capacity and phenolic acids of virgin coconut oil by Marina AM1, Man YB, Nazimah SA, Amin I.(PubMed)
(215) Coconut (Cocos nucifera L.: Arecaceae): in health promotion and disease prevention by DebMandal M1, Mandal S.(PubMed)
(216) Effects of coconut oil on testosterone-induced prostatic hyperplasiain Sprague-Dawley rats by de Lourdes Arruzazabala M1, Molina V, Más R, Carbajal D, Marrero D, González V, Rodríguez E.(PubMed)
(217) Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil by Intahphuak S1, Khonsung P, Panthong A.(PubMed)
(218) Caprylic Acid and glyceryl trinitrate combination for eradication of biofilm by Rosenblatt J1, Reitzel RA2, Raad I2.(PubMed)
(219) Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infectionsby Bjarnsholt T1, Jensen PØ, Rasmussen TB, Christophersen L, Calum H, Hentzer M, Hougen HP, Rygaard J, Moser C, Eberl L, Høiby N, Givskov M.(PubMed)
(220) An in vitro assessment of the antibacterial effect of garlic (Allium sativum) on bacterial isolates from wound infectionsby Tessema B1, Mulu A, Kassu A, Yismaw G.(PubMed)
(221) Antileishmanial activity of a mixture of Tridax procumbens and Allium sativum in mice by Gamboa-Leon R1, Vera-Ku M1, Peraza-Sanchez SR2, Ku-Chulim C1, Horta-Baas A1, Rosado-Vallado M1.(PubMed)
(222) The effects of oral garlic on vaginal candida colony counts: a randomised placebo controlled double-blind trial by Watson CJ1, Grando D, Fairley CK, Chondros P, Garland SM, Myers SP, Pirotta M.(PubMed)
(223) Effects of ginger constituents on the gastrointestinal tract: the role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptorsby Pertz HH1, Lehmann J, Roth-Ehrang R, Elz S.(PubMed)
(224) Ginger (Zingiber officinale Roscoe) prevents the development of morphine analgesic tolerance and physical dependence in rats by Darvishzadeh-Mahani F1, Esmaeili-Mahani S, Komeili G, Sheibani V, Zare L.(PubMed)
(225) Stimulative and sedative effects of essential oils upon inhalation in mice.by Lim WC1, Seo JM, Lee CI, Pyo HB, Lee BC.(PubMed)
(226) Zingiber officinale Roscoe (ginger) as an adjuvant in cancer treatment: a review by Pereira MM1, Haniadka R, Chacko PP, Palatty PL, Baliga MS.(PubMed)
(227) Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria by Park M1, Bae J, Lee DS.(PubMed)
(228) Zerumbone enhances the Th1 response and ameliorates ovalbumin-induced Th2 responses and airway inflammation in mice by Shieh YH1, Huang HM2, Wang CC3, Lee CC4, Fan CK5, Lee YL6.(PubMed)

#Antioxidant #Lectin Found in Chickpeas Inhibits #Oralcancer Cells by Reducing Cell Proliferation and Shrinking the Cancer Site, According to Studies

Kyle J. Norton

Chickpeas lectin may have a profound effect in ameliorating the risk and treatment of oral cancer, some scientists suggested.
Garbanzo beans also known as chickpea are an edible legume of the genus Cicer belonging to the family Fabaceae.

The bean is considered one of the legumes containing a high amount of protein and minerals.

It is one of the earliest cultivated vegetables, native to the Middle East.

Oral cancer is a medical condition characterized by cell growth disorderly and uncontrollably in the mouth region. At the later stage, the cancerous cell may travel a distance away from the original site to infect healthy tissues and organs.

Investigation of the process of chickpea lectin in reduced oral cell proliferation and tumor expansion
may involve the expression of several aspects and mechanisms.

According to the All India Institute of Medical Sciences, chickpeas inhibited the proliferation of human oral carcinoma cells at the concentration of 37.5 μg/mL (IC50) and had no toxic effect.

Further analysis, chickpeas anti-cancer activity probably was a result of the pro-apoptotic effect induced by the phytochemical agent lectin found abundantly in the legume.

Lectin is a type of protein with the important function of binding to cell membranes and influencing cell-cell interaction.

In an experiential oral cancer cell line, injection of leptin showed a significant effect in inhibition of the p38α MAP kinase-activated under cellular stresses in response to inflammatory cytokines and involved function in the control of many other aspects of the physiology of the cell, such as control of cell cycle or cytoskeleton remodeling,.. for cell survival of cancer in presence of substrate (ATP).

By blocking the physiological expression of a cancer cell, lectin reduced cell proliferation and subsequently, shrinks the cancer site.

Furthermore, a petrochemical lectin isolated from chickpeas also demonstrated a binding affinity with p38α in regulating the production of certain inflammatory cytokines such as tumor necrosis factor (TNF), interleukin (IL)-1, IL-6 which may have certain effects in the induction of cancer growth.
The kinase p38α MAPK (p38α) is a pro-apoptotic enzyme. played a pivotal role in many biological processes, including protecting the cell in responses to inflammation and injury,

Specifically, in the influence of the production of inflammatory cytokines by p38α, lectin regulated the potent pro-inflammatory cytokine produced by cells of the innate immune system IL-1β in the induction of tumor growth and metastasis in cells under prolonged periods of inflammation.

According to general belief, many cancers have been found to arise from sites of infection, chronic irritation, and inflammation.

In tumor necrosis factor-alpha TNF-α, the application of chemical lectin to oral cancer site suppressed the inflammatory expression of the protein in induced cell survival and proliferation and promoted the pro-apoptotic function of TNF-α in a program of cell death and cell cycle arrest.

Tumor necrosis factor-alpha TNF-α is cell signal protein with function in induced inflammation in the acute phase of injury and in a number of cellular processes, including cell survival, proliferation, differentiation, and death.

Importantly, the binding of kinase p38α MAPK also activated the function of IL-6, in inhibiting the factors in the induced production of inflammatory cytokines which have a negative impact in oral cell oncogenesis and enhance the expression of boosting T cell trafficking to tumor sites to induce the cytotoxic effect.

IL-6, an interleukin with duo functions in both pro-inflammatory cytokines and anti-inflammatory myokines,

Taken together, chickpea lectin may be considered a functional food in the prevention of oral cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antifungal and antiproliferative protein from Cicer arietinum: a bioactive compound against emerging pathogens by Kumar S1, Kapoor V2, Gill K1, Singh K1, Xess I3, Das SN2, Dey S1(PubMed)
(2) Cell surface interaction of annexin A2 and galectin-3 modulates epidermal growth factor receptor signaling in Her-2 negative breast cancer cells by Shetty P1,2, Bargale A3,4, Patil BR5, Mohan R6, Dinesh US7, Vishwanatha JK8, Gai PB9, Patil VS3,4, Amsavardani TS10. (PubMed)
(3) Antibody and lectin target podoplanin to inhibit oral squamous carcinoma cell migration and viability by distinct mechanisms by Ochoa-Alvarez JA1, Krishnan H1, Pastorino JG1, Nevel E1, Kephart D1, Lee JJ1, Retzbach EP1, Shen Y1, Fatahzadeh M2, Baredes S3, Kalyoussef E3, Honma M4, Adelson ME5, Kaneko MK6, Kato Y6, Young MA1, Deluca-Rapone L1, Shienbaum AJ1, Yin K1, Jensen LD7, Goldberg GS1.(PubMed)

#Tomato and #Carrot Juices Show A Strong Effect on Immunity Against Normal Cell Damages Caused by Indlammation and Cytotoxicy

Kyle J. Norton

Carrots and tomatoes and their major bioactive carotenoids may have a profound and positive effect to boost immunity, some scientists suggested.

The results of the studies were carried out by numbers institutes in numbers of different differentiation, including Institute of Nutritional Physiology, Federal Research Centre for Nutrition.

You can also view the abstract by clicking the links in the resources.

Immunity is a natural defense of an organism with an aim to protect the host to resist a particular infection or toxin through the expression of antibodies or sensitized white blood cells.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.

Tomato is red, edible fruit, genus Solanum, belongings to the family Solanaceae, native to South America.
Because of its health benefits, the tomato is grown worldwide for commercial purposes and often in the greenhouse.

In the investigation of the effect of beta-carotene has been shown to enhance immune functions in humans, the Institute of Nutritional Physiology, Federal Research Centre for Nutrition launched a study to examine whether vegetables rich in carotenoids, such as beta-carotene or lycopene, exert any modulation of immune function in healthy humans.

The blinded, randomized, cross-over study, included male subjects on a low-carotenoid diet consumed 330 ml/day of either tomato juice(37.0 mg/day lycopene) or carrot juice (27.1 mg/day beta-carotene and 13.1 mg/day alpha-carotene) for 2 weeks with a 2-week depletion period after juice intervention.

Epidemiological studies suggested that consuming carotenoids from food sources may provide a variety of health benefits including a reduced incidence of cancers, risk of cardiovascular disease, and improved eye health,.......

Reading of the immune status was assessed by measuring the related activity of natural killer (NK) cells, secretion of cytokines ( IL-2, IL-4, TNF-alpha), and proliferation by activated peripheral blood mononuclear cells((T cells, B cells, NK cells).

Natural killer cells is a type of white blood cells that formed a component of the innate immune system with function in inhibited microorganisms infected cells.

Interleukin-2 (IL-2) is a type of inflammatory cytokine with a function in signaling molecules in the immune system to protect the body against bacterial and viral in the acute phase of infection.

Interleukin-4 (IL-4) activated by lymphoid cells is the inflammatory cytokine critical for initiating humoral immunity against extracellular pathogens.

Both Interleukin-2 and 4 (IL-2and 4 ) play an important role in chronic inflammation and wound repair.

Tumor necrosis factor (TNF) including, tumor necrosis factor-alpha, TNFα, cachexia, or cachectin) is a protein (cytokine) involved in systemic inflammation during the acute phase of infection.

At the end of the experiment, researchers found that
* Both juices treated participants demonstrate relatively fast responses in plasma carotenoid concentrations (p < 0.0002) without inducing concomitant changes in immune functions.

* Intake of both tomato and carrot juice displays a significant activity of immunity in the production of IL-2, NK cell cytotoxicity, and lymphocyte proliferation with maximum responses observed during depletion periods.

* Compared to the secretion of other inflammatory cytokines, TNF alpha exerts only at the end of the first intervention period.

* During the course of innervation, both juices show insignificant effects in modulated the secretion of IL-4.

These result suggested that lower plasma carotenoid concentrations in the bloodstream may reduce the immune function in response to diseases caused by bacterial and viral infection, particularly in the acute phase.

Occasional intake of tomato and carrot juice does not enhance body immunity, due to its function in the time-delayed modulation of immune functions and its degradation caused by numbers of factors, including heat, light, oxygen, acid, transition metal, or interactions with radical species.

The conclusion truly addressed the importance of carotenoids in modulated immune response in the protection of bodily injury or damage during the acute phase of infection through inhibiting pro-inflammatory overexpression in the induction of cytotoxicity and damage to nearby healthy cells.

Further to reaffirm the effects of the consumption of carotenoid-rich vegetables on the immune system, the Institute of Nutritional Physiology, Federal Research Centre for Nutrition conducted a study of 23 non-smokers, male subjects, who were not restricted in their daily diet, except that they had to abstain from fruit and vegetables high in carotenoids throughout the whole study period with blood collected weekly from subjects after a 12 h fast.

The study was also divided into four periods, each lasting 2 weeks: * Weeks 1-2: low-carotenoid period;

* Daily consumption of 330 ml tomato juice (40 mg lycopene/d, 1.5 mg beta-carotene/d) (weeks 3-4),
* 330 ml carrot juice (21.6 mg beta-carotene/d, 15.7 mg alpha-carotene/d, 0.5 mg lutein/d) (weeks 5-6)
* 10 g dried spinach powder (11.3 mg lutein/d, 3.1 mg beta-carotene/d) (weeks 7-8).

According to the assessment of T-lymphocyte and secretion of immunoreactive cytokines, lower concentration due to consumption of a low-carotenoid diet exerted a significantly reduced proliferation of function immune system observed in peripheral blood mononuclear cells (PBMC) cultured with concanavalin A.

At the end of the first 2 weeks of tomato juice consumption and until the end of the intervention period, researchers found that intake of tomato juice with abundant carotenoids induced an insignificant change in lymphocyte proliferation compared to the concentration at the end of the depletion period.

Similarly, the experiment also exerted a strong immune modulated effect in the assessment of the secretion of cytokines interleukin (IL)-2 and -4).

The dietary intervention improved the IL-2 and IL-4 secretion values. however, the levels of IL-2 and IL-4 were significantly suppressed after the low-carotenoid diet.

The results at the end of the period also expressed the similarity of other studies " After carrot juice and spinach powder consumption the cytokine secretion capacity of PBMC was not significantly different from that at the end of the depletion period".

Dr. Watzl B, the lead author after taking into account other co and confounders said, "The results of the present study indicate that a low-carotenoid diet reduces T-lymphocyte functions and the addition of tomato juice restores these functions".

The unexplained changes in the plasma carotenoid concentrations, probably severed as an indication that other phytochemicals or other mechanisms in tomato and carrot juice may have a strong implication in modulated immune response other than cytokine secretion capacity of PBMC.

Taken together, tomato and carrot juice and their bioactive carotenoids may be considered as functional foods in boosting immune function against foreign organisms, particularly, in the acute phase of infection.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299


Sources
(1) Supplementation of a low-carotenoid diet with tomato or carrot juice modulates immune function in healthy men by Watzl B1, Bub A, Briviba K, Rechkemmer G(PubMed)
(2) Modulation of human T-lymphocyte functions by the consumption of carotenoid-rich vegetables by Watzl B1, Bub A, Brandstetter BR, Rechkemmer G.(PubMed)
(3) Factors influencing the chemical stability of carotenoids in foods by Boon CS1, McClements DJ, Weiss J, Decker EA(PubMed)

Intake of #Coffee Less Than or Equal to 240 ml (8-oz) Daily and Regularly Reduces the Risk of the Formation of Kidney Stones

Kyle J. Norton

Food therapy is a model of diet, using foods as a form of medicine for healing purposes by centered on concepts of food that contain ingredients for the treatment of diseases if eaten in moderation.

However, the concept may be the best practice in disease prevention. In the treatment of ailments, food theory takes longer to ease symptoms, depending on the stages of the treatment that directly address the cause of the disease.

Kidney stones are composed of mineral salts formed in the kidneys.

The single cause of kidney stones is debatable. However, some researchers suggested that dehydration, food restriction, Rotavirus infection, over intake of calcium and supplements,,,, and high fat intake are associated with an increased risk of forming kidney stones (4).

According to statistics, kidney stones affect over 10% of the world's population.

Men account for 80% of those with kidney stones and are at risk of forming between 30 and 40 years of age.

About 75% of kidney stones are calcium stones.

Symptoms of a kidney stone include excruciating intermittent pain, usually in the flank (the area between the ribs and hip), that spreads across the abdomen, often to the genital area and inner thigh.

The pain tends to come in waves, gradually increasing to a peak intensity, then fading, over about 20 to 60 minutes.

The pain may radiate down the abdomen toward the groin or testis or vulva(4).

If you experience the above symptoms, you may have kidney stones please see your doctor as soon as possible.

Epidemiological studies linking coffee and caffeine intake in the risk of kidney stone formation are totally dependent on the daily amount of consumption.

Coffee, a popular and social beverage worldwide, particularly in the West, is a drink made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.

According to the Warsaw Agricultural University, coffee and tea consumed daily and regularly expressed an increased risk of kidney stones by more than 80% compared to the risk of other factors, probably due to the presence of oxalates if the amount of intake is over 240 ml (8-oz) daily.

In fact, in the analyzed nutritional habits of 22 stone formers with special regard to oxalate content as one of the main nutritional lithogenic factors associated with kidney stones, researchers found that the risk of kidney stones increased substantially for men and women if dietary oxalate intake was over 354 mg and 406 mg, respectively.

In a total of 217,883 participants; over a median follow-up of >8 y, 4982 incident cases of kidney stone occurred studies, researchers file the following results.

1. The highest quintile of caffeine intake (95% CI: 12%, 38%) showed a significantly reduced risk of developing stones by 26%, according to the Health Professionals Follow-Up Study (HPFS).
2. Caffeine intake showed a 29 % lower risk in the NHS I cohort, and
3. and 31% lower risk in the NHS II cohort

Dr. the lead author said. "Among 6033 participants with 24-h urine data, the intake of caffeine was associated with higher urine volume, calcium, and potassium and with lower urine oxalate and supersaturation for calcium oxalate and uric acid".

Furthermore, a prospective study investigated the relationship between the intake of 21 different beverages and the risk of symptomatic kidney stones in a cohort of 45,289 men, 40-75 years of age conducted the Harvard School of Public Health, suggested that the risk of stone formation decreased by 10%. of the amount for each 240-ml (8-oz) serving consumed daily in caffeinated coffee.

Taking it all together, the findings demonstrated a significant effect of caffeinated coffee intake of less than or equal to 240 ml (8-oz) in decreased risk of formation of kidney stones.

Due to the small example size of the above studies, further data collection on large sample size and multi-center clinical studies performed with human consumption during the course of the investigation will be necessary to complete the picture of caffeinated coffee intake of fewer than 240 ml (8-oz) in reduced risk of kidney stone possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tea and coffee as the main sources of oxalate in diets of patients with kidney oxalate stones by Gasińska A1, Gajewska D.(PubMed)
(2) Caffeine intake and the risk of kidney stones by Ferraro PM1, Taylor EN1, Gambaro G1, Curhan GC1.(PubMed)
(3) Prospective study of beverage use and the risk of kidney stones by Curhan GC1, Willett WC, Rimm EB, Spiegelman D, Stampfer MJ.(PubMed)
(4) Kidney stone by Kyle J. Norton

#Phytochemical #Isothiocyanates Found in #SteamedBroccoli Exerts the Cardio-Protective Effects Ag #CaediovascularDisease, Researchers Suggest

Kyle J. Norton

Bioactive dithiolthiones found in cruciferous vegetables may be the next-generation ingredient for the prevention and treatment of cardiovascular disease, some scientists suggested.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

Cardiovascular disease is a class of conditions associated with the heart and blood vessels. In other words, CVD can be a result of anything that impedes the function of the heart and blood vessels.

According to the CVD statistics, heart disease kills more than 2,000 Americans every day. Approximately 60 million Americans have heart disease.
There are many causes of cardiovascular disease. Most CVD is caused by high blood pressure which contributes to the hardening of the arteries.

Plaques building up inside the arteries as a result of high blood cholesterol and other substances such as calcium over time can harden and narrow the arteries, leading to a blood clot, a major cause of CVD.

Other risk factors associated with the onset of cardiovascular disease include an unhealthy diet, lack of exercise, being overweight, and smoking.

Dr. Haskell W, Stanford University, School of Medicine in the examine the lifestyle change in the risk of CVD indicated that there is a strong relationship between the way a person or population lives and their risk for developing or dying from cardiovascular disease (CVD).

How to prevent the onset of CVD
He wrote, "Not smoking, being physically active, eating a heart-healthy diet, staying reasonably lean, and avoiding major stress and depression are the major components of an effective CVD prevention program"/

For people with higher-risk CVD, the doctor continued, "medications frequently need to be added to a healthy lifestyle to minimize their risk of a heart attack or stroke, particularly in persons with conditions such as hypertension, hypercholesterolemia, or hyperglycemia".


With an aim to find a natural ingredient or whole food with a cardioprotective effect, researchers examined whether sulforaphane protects the heart against I/R injury.

Sprague-Dawley rats selected for the study were given sulforaphane (500microg/kg/day) or vehicle intraperitoneally for 3 days and global ischemia was performed using isolated perfused Langendorff hearts.

Treatment with sulforaphane inhibited an increase in the post-ischemic left ventricular end-diastolic pressure (LVEDP) and improved the post-ischemic left ventricular developed pressure (LVDP), +/-dP/dt, and coronary flow as compared with the untreated control hearts.


Sulforaphane markedly decreased the infarcted size and attenuated the increased lactate dehydrogenase level in effluent during reperfusion, similar to that of 5-hydroxydecanoic acid (5-HD).

Application of sulforaphane also attenuated the post-ischemia increased the concentration of atrial natriuretic peptide in coronary effluent and decreased levels of free radicals produced during and after injury.

Particularly, sulforaphane also protected the heart cell against damage and apoptosis by promoting heart cell cycle division.

The finding clearly indicated the cardioprotective effect of the sulforaphane against acute I/R injury.

In order to understand the therapeutic effect of sulforaphane protecting the myocardium from ischaemic reperfusion injury, researchers compared the cardio effects among cooked and fresh broccoli.

The study included two groups of rats fed with fresh (steamed) broccoli or cooked broccoli for 30 d, while a third group was given vehicle only for the same period of time.

At the end of the study, by examing the 30 min ischemia followed by 2 h of reperfusion, researchers surprisingly found that both cooked and steamed broccoli display significantly improved post-ischaemic ventricular function and reduced myocardial infarction and cardiomyocyte apoptosis compared to control, but steamed broccoli showed superior cardioprotective abilities compared with the cooked broccoli.

These results were attributed to the broccoli effect in enhancing the levels of proteins associated with cell survival, increasing the levels of antioxidants, and decreasing the levels of proteins associated with cell damage and apoptosis.

More importantly, the expressions of redox proteins (the thioredoxin (Trx)) associated with the reduction of oxidative stress were enhanced only in the steamed broccoli group.

Dr. Mukherjee S, the lead scientist said, "The present study documented superior cardioprotective properties of the steamed broccoli overcooked broccoli because of the ability of fresh broccoli to perform redox signaling of Trx"

Taken together, Isothiocyanates or sulforaphane may have a potential effect on the prevention and treatment of cardiovascular disease.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References

(1) Sulforaphane protects ischemic injury of hearts through an antioxidant pathway and mitochondrial K(ATP) channels. by Piao CS1, Gao S, Lee GH, Kim do S, Park BH, Chae SW, Chae HJ, Kim SH. (PubMed)
(2) Comparison of the protective effects of steamed and cooked broccolis on ischemia-reperfusion-induced cardiac injury. by Mukherjee S1, Lekli I, Ray D, Gangopadhyay H, Raychaudhuri U, Das DK. (PubMed)
(3) Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging by Chapple SJ1, Siow RC, Mann GE .(PubMed)
(4) Cardiovascular disease prevention and lifestyle interventions: effectiveness and efficacy by Haskell WL. (PubMed)