#Blackbeans Inhibit the Risk of #ColonCancer Through Anti-Proliferative Properties, Researchers Say

Kyle J. Norton

Black bean may have a profound effect in reducing and treatment of colon cancer, some scientists suggested.
The colon also known as the large bowel or large intestine, is the part of the digestive system in our body.

Colon cancer is a chronic condition caused by cell growth irregularly and disorderly in the colon due to the alternation of DNA.

Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. At this stage, patients may not experience any symptoms.

After penetrating deeper into the colon layer, the cancer cells may travel a distance away to infect other healthy tissue and organs through fluids and blood circulation.

At this stage, the increased size of the tumor may suppress the nearby tissue, organs or nerves cells causing localized symptoms and severe pain.

The most common colon cancer metastasis is in the lungs and liver.

According to epidemiological studies, the most common risk factors of colon cancer are older

age, ethnicity, personal and family history of colorectal cancer or polyps, inflammatory intestinal conditions.

Particularly, people who follow the low-fiber, high-fat diet or have a sedentary lifestyle. are associated with a substantial risk for the onset of the disease.

Dr. Y J Cong, the lead author in the concerns of the sedentary behavior in risk of colon cancer in modern society, launched an investigation to examine the association of sedentary behavior with colon and rectal cancer.

The search of the databases of PubMed, Embase, and Google Scholar databases up to May 2013 to identify cohort and case-control studies that evaluated the association between sedentary behavior and colon or rectal cancer identified 23 studies with 63 reports including 4 324 462 participants.

After assessing the results of all the studies, the doctor team wrote. "Sedentary behavior is associated with an increased risk of colon cancer. Subgroup analyses suggest a positive association between sedentary behavior and risk of rectal cancer in cohort studies".

Black bean is a Small roughly ovoid legume with glossy black shells, genus Phaseolus, belonging to the family Fabaceae.

The bean can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

The major chemical compounds of black bean include anthocyanin, (-)-epicatechin, delphinidin, petunidin, flavonols, and malvidin.

In finding a natural whole food for the treatment of colon cancer, researchers at the Tecnológico de Monterrey-Campus Monterrey conducted an investigation to examine the black bean antioxidant capacity and antiproliferative activity against cancer cell lines.

Flavonoids extracted from seed coats exerted a potential effect against colon cancer cell line'

The extracts obtained from seed coats after 3 and 5 germination days inhibited all cancer cell line proliferation, including the tested colon cancer with no cytotoxicity against control cells.

Further analysis also suggested that flavonols and group B saponins isolated from the seed coat were more related to hepatic and colon cancers.

These results indicated that not all chemical compounds found in black beans have a potential effect in the inhibition of colon cancer. However, the intake of the black bean as a whole food may have significant effects in reducing the risk of colon cancer.

Additionally, in the finding evidence to suggest an inverse relationship between bean consumption and colon cancer, researchers at the Food Science program at the Michigan State University conducted a study to determine whether consumption of black beans and/or navy beans would reduce colon carcinogenesis in rats.

Selected rat group were fed a modified AIN-93G diet (control) or diets containing 75% black beans or 75% navy beans for 4 wk, and then colon cancer was initiated by the administration of two injections of azoxymethane 1 wk apart.

At 31 wk after the second injection, the incidence of colon adenocarcinomas was significantly lower in rats fed the black bean (9%) than in rats fed the control diet (36%).

Total tumor multiplicity was also significantly lower in rats fed the black bean diet than in rats fed the control diet.

After taking into account co and confounders, Dr. Hangen L, the lead author said, "The 44-75% reduction in colon carcinogenesis in rats fed beans was attributed to 1) more controlled appetites, leading to significantly less body fat, and 2) much greater concentrations of butyrate in the distal colon".

These results suggested black beans only have a potential effect in lowering the risk of colon cancer. but also stop cells multiplicity in the case of colon cancer.

However, further data collection of large example size and multi-center studies performed with human consumption of whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of black bean anti-colon cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



References
(1) Differential accumulation of polyphenolics in black bean genotypes grown in four environments.
Marles MA, Balasubramanian P, Bett KE. (PubMed)
(2) Evaluation of the antioxidant and antiproliferative activities of extracted saponins and flavonols from germinated black beans (Phaseolus vulgaris L.).
Guajardo-Flores D, Serna-Saldívar SO, Gutiérrez-Uribe JA(PubMed)
(3) Consumption of black beans and navy beans (Phaseolus vulgaris) reduced azoxymethane-induced colon cancer in rats. by Hangen L, Bennink MR. (PubMed)
(4) Association of sedentary behavior with colon and rectal cancer: a meta-analysis of observational studies by bY J Cong,1 Y Gan,1 HL Sun,1 J Deng,1 S Y Cao,1 X Xu,1,2 and Z X Lu. (PubMed)

#Aqueous Extracts of #Redpepper Show a Cytotoxicic Effect on Cancers, Scientists Find

Kyle J. Norton

Scientists may have found a kitchen spice which processes a potential for reducing risk and treatment of cancers, some studies suggested.
Cancers are a class of chronic and medical conditions characterized by cells growing irregularly and disorderly.

Most cancers start on the surface of the inner lining of organ tissue. At this early stage, patients may not experience any symptoms.

At the later stage, most cancerous cells can travel a distance away from the original site to infect other healthy tissue via fluid and blood circulation.

As of today, researchers do not know the exact cause of cancer neither they know why people with the same health condition and family history, some are susceptible to DNA alternation in facilitating the onset of cancer, while others do not.

There are many prevalent risk factors associated with the cancer onset, depending on the primary location, including an increase of age, excessive alcohol consumption, exposure to chemical toxins and sunlight, and infectious pathogens.


Noticeably, in the study of "Dietary and Lifestyle Risk Factors for Colorectal Cancer in Apparently Healthy Adults in Jordanian Hospitals" conducted by the joint investigation lead by the Jordan University of Science and Technology, Dr. Omran S, the led author said, "Colorectal cancer (CRC) risk is expected to continue rising due to dietary patterns, sedentary lifestyle, and other practices" and "Data was collected using a self-report questionnaire measuring sociodemographic characteristics, dietary habits, physical activity, and lifestyle risk factors of CRC. The mean age of participants was 57.0 ± 8.56 years. The majority of participants were male (71.8 %) and with less than secondary school formal education (60.7 %). The commonest risk factors for CRC among the participants were overweight or obesity (76.1 %), lack of exercise (71.6 %), limited consumption of vegetables (70.8 %), smoking (60.6 %), over-consumption of red meat (56.3 %), and diabetes mellitus (24.1 %)".

These results suggested that by following a healthy diet with less saturated and trans fat, red meat and processed food, and more fruits and vegetables and lifestyle, the risk of cancers can be reduced substantially.

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.

The spicy herb has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.


In the study to examine whether Capsaicin, a pungent phytochemical in a variety of red peppers processes an anti-proliferative effect on numbers of cancer, researchers at the Changhua Christian Hospital, launched an investigation of cell proliferation/viability and cytotoxicity of KB cells exposed to capsaicin.

In human KB cancer cells, application of capsaicin exerted a significant effect in reducing cancer cell proliferation/viability and induced cell death in a dose-dependent manner compared to untreated control.d t

In cell cycle analysis, capsaicin inhibits cancer cell division n in cell cycle arrest at G2/M phase of KB cells.

Further analysis suggested that capsaicin growth inhibition of KB cells was attributed mostly in the induction of cell apoptosis, through disrupting the pathway associated with cancer cellular response in differentiation, proliferation, and survival.

Interestingly, in the concerns that diet pattern and selection may be associated with the risk of cancer onset, researchers at the Inst. of Cytology and Preventive Oncology (ICMR) launched an investigation to examine the effects of Indian diet's many unique dietary constituents, including spices like chili pepper, cloves, black pepper and black cumin on the cancers' risk.


Application of pungent spice including red pepper extract exerted a cell antiproliferative activity against the TE-13 (esophageal squamous cell carcinoma) cell line.

All extracts showed cytotoxic activity, but aqueous extracts of red pepper were found to be more potent than alcoholic extracts.

In morphological analysis, DAPI staining and DNA fragmentation assay, the aqueous extract of chili pepper at 300 μl/ml. demonstrated maximum cell death and apoptotic cell demise (88%) to occur within 24 hours compared to other pungent spicy extracts.

The finding suggested that herbal Cayenne containing a high amount of capsaicin may be considered a functional food and adjunct therapy for reducing the risk of cancers with no side effects.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Capsaicin induces cell cycle arrest and apoptosis in human KB cancercells by Lin CH, Lu WC, Wang CW, Chan YC, Chen MK. (PubMed)
(2) Cytotoxic potential of Indian spices (extracts) against esophageal squamous carcinoma cells. (PubMed)
(3) Dietary and Lifestyle Risk Factors for Colorectal Cancer in Apparently Healthy Adults in Jordanian Hospitals by Omran S1, Barakat H2, Muliira JK3, McMillan S. (PubMed)

#Phytochemical #Ruscogenin Isolated from Herbal #Butchersbroom Exerts Antioxidant Activities Against the Onset of Acute and Chronic Inflammatory Diseases Remedy, Scientists Say

Kyle J. Norton


Scientists may have found a potential herbal medicine's ingredient for the treatment of acute and chronic inflammation with no side effects, some studies suggested.

Inflammation is a systematic immune response during the acute phase of infection.

Macrophages, one of the lymphocytes and the first line of defense of the immune system after sensing the damage of localized tissue, stimulate the production of proinflammatory cytokines to the site to protect the body against the invasion of potential pathogens.

However, in some cases, overexpression of proinflammatory cytokines can cause the death of nearby healthy cells, leading to abnormal skin healing and the formation of irreversible scars.

Chronic inflammation is a result of a prolonged period of inflammation that lasts for several months and even years caused by the inability of the immune system to kill off all harmful microorganisms during the acute phase of infection.

Chronic inflammation can also be caused by an autoimmune disorder in which the immune system continuously attacks normal and healthy tissue, by mistaking them for causable pathogens.

Low-grade inflammation is a different type of chronic inflammation characterized by the production of inflammatory cytokines in a low-grade state.

Epidemiological studies, linking chronic inflammation to certain diseases such as heart disease or stroke, have been under investigation in many scientistic communities. However, as of today, scientists still do not know why people with the same health conditions and family history, are susceptible to the onset of chronic inflammation while others do not.

If you experience some of the symptoms such as persistent body pain, fatigue, and insomnia. depression, anxiety and mood disorders, gastrointestinal complications, and frequent infection. Please check with your doctor to rule out the possibility of certain diseases.

Butcher's broom is a low evergreen shrub, a species of Ruscus aculeatus, belonging to the family Asparagaceae, native to Eurasia.

The herb has been used in herbal medicine to treat and reduce inflammation, Peripheral vascular disease, Hemorrhoids Bronchial asthma, Varicose veins, Hypotension, Jaundice, functional disorders of the heart, kidney disorder, venotonic and anti-oedematous properties, etc...

The chemical ingredients include rutin, sitosterol, sparteine, spirostanol saponins, steroidal sapogenins, sterols, stigmasterol, sulfated steroidal saponins, sweet broom, tetracosanoic acid, triterpenes, triterpenes, and tyramine.

In the study to reaffirm traditional Chinese medicine use of Butcher's broom for the treatment of -inflammation and thrombosis, researchers at the China Pharmaceutical University, Nanjing launched an investigation to examine the anti-inflammatory and anti-thrombotic activities of Ruscogenin (RUS), isolated from Butcher's broom.

Application of Ruscogenin demonstrated a remarkably inhibited adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV304) damage by the proinflammatory factor tumor necrosis factor-alpha (TNF-alpha) in a concentration-dependent manner, in vitro.


On leukocyte migration and celiac prostaglandin E(2) (PGE(2)) level induced by zymosan A in mice, injection of ruscogenin significantly suppressed zymosan A-evoked peritoneal total leukocyte migration in the initiation of inflammation, in mice in a dose-dependent manner, while the bioactive had no obvious effect on PGE(2) content in peritoneal exudate cells, participating in the forming of exudate during inflammation.

These results suggested that Ruscogenin exerts a significant anti-inflammatory activity by inhibiting TNF-alpha and suppressing NF-kappaB activation in the inflammatory response during bacterial infection.

In the development of monocrotaline (MCT)-induced inflammation of pulmonary arterial hypertension (PAH). in rats, researchers found that
* Application of ruscogenin displays a strong effect on hemodynamics and pulmonary vascular inflammatory remodeling and prevents the development of PAH 3 weeks after injection of MCT.
* Ruscogenin inhibits lung inflammation by reducing the expression of inflammatory cytokine and immune leukocyte infiltration by limiting the action of nuclear factor (NF)-κB in the activation of the immune response.

Additionally, ruscogenin also restores the function of pulmonary arterioles and prevent the death of endothelial cell induced by the injection of MCT.

Taken altogether, herbal Butcher's broom processes high amounts of bioactive ingredient ruscogenin may be considered an adjunct therapy or combined with conventional medicine for treatment of acute and chronic inflammatory diseases, pending on the large example size and multi-center studies.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear factor-kappaB by Huang YL, Kou JP, Ma L, Song JX, Yu BY. (PubMed)
(2) Ruscogenin attenuates monocrotaline-induced pulmonary hypertension in rats by Bi LQ, Zhu R, Kong H, Wu SL, Li N, Zuo XR, Zhou SM, Kou JP, Yu BY, Wang H, Xie WP. (PubMed)

#Papaya Extract Inhibits the Total Cholesterol, Triglycerides, and Low-Density Lipoproteins Level, and Increases High-Density Lipoprotein Levels, According to Studies

Kyle J. Norton

Papaya may be considered a functional food for high blood cholesterol without inducing any side effects, some scientists suggested.

Cholesterol, a waxy substance produced by the liver or from the intake of dietary sources plays an important role in the building of cell membranes in transmitting information among cells and making steroid hormones, fat-soluble vitamins, and bile acids for digestive system needs.

There are 2 major types of cholesterol,
* Low-density lipoproteins (LDL) are also known as“bad” cholesterol. High levels of LDL cholesterol can block the arteries, causing heart disease. and

* High-density lipoproteins (HDL) are known as“good” cholesterol. HDL cholesterol removes bad cholesterol from other parts of your body and carries them back to the liver.

The healthy ratio of total cholesterol is 4 (bad cholesterol)/1(good cholesterol). If your total blood cholesterol is lower than 4, you are considered a have a healthy level of blood cholesterol.

The Mayo Clinic in the article talking about diet and lifestyle effects in high blood cholesterol wrote, "Poor diet. Eating saturated fat, found in animal products, and trans fats, found in some commercially baked cookies and crackers, can raise your cholesterol level. Foods that are high in cholesterol, such as red meat and full-fat dairy products, will also increase your total cholesterol".


Therefore, by changing your diet pattern to more in fruits, whole grains, and vegetables and less in saturated and trans fat, red meat, and processed food, and following a healthy lifestyle with moderate exercise, you should be free of the syndrome of high blood cholesterol, regardless of your present conditions.

Papaya is a species of Carica Papaya, belongs to the family Caricaceae and is native to the tropics of the Americas, and was first cultivated in Mexico several centuries

In the reaffirming of the traditional use of Ficus carica (papaya) for the treatment of several metabolic syndrome-related health problems, researchers at the University of Florida launched an investigation to examine the preventive effects of a Ficus carica (FC) leaf extract on hyperlipidemia in high-fat diet (HFD)-induced obese male rats.

Male Sprague-Dawley rats (180-200 g) were fed with a regular diet, HFD, or an HFD + oral treatment of either 50 mg/kg or 100 mg/kg of FC or 30 mg/kg pioglitazone for six weeks.

In the final report, researchers found that
* Oral administration of FC exerts a significant anti-hyperlipidemia effect by lowering triglycerides (TG), interleukin-6 (IL-6) levels, and elevated high-density lipoprotein cholesterol (HDL-C) in the tested animal.
* The effects of FC on lipid parameters are more pronounced in treated rats than those of the positive control pioglitazone.
* FC treatment group also significantly lowered the atherogenic index (AI) and the coronary risk index (CRI). the indications of the decreased risk of atherosclerosis and coronary artery disease.

Dr. Joerin L, the lead author said, "Preventive treatment with FC significantly improved the lipid profile and decreased adipogenic risk factors in HFD rats most likely mediated through an increase in HDL-C levels".

Additionally, in the evaluate the effects of the fruit and latex of papaya used in folk medicine for the treatment of hyperlipidemia, researchers conducted an experience to examine the anti-hyperlipidemic effect of the ether- and water-soluble fractions of C. papaya ethanol extract in olive oil-induced hyperlipidemic rats.

The extract and fractions were administered orally at doses of 200 and 400 mg/kg body weight in rats. Olive oil (5 mL/kg oral dose) was administered 30 min after treatment.

Oral administration of papaya extract in a dose-dependently inhibited the total cholesterol (TC), triglycerides (TG), and low-density lipoproteins (LDL) level, and significantly increased high-density lipoprotein (HDL) levels.

Papaya also exerted a significant acute effect on HDL levels and TC and TG elevation induced by olive oil.

These results suggested that papaya extract and water fraction showed protective action by increasing the HDL cholesterol level and lowering the levels of HDL level and TC and TG elevation in hyperlipidemic rats.

Taken together, papaya may be considered a functional food for the treatment of high blood cholesterol.

However, due to the limitation of the above studies, additional data collection large example size and multi-center studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of papaya antihyperlipidemic possibility.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Chemical composition and bioactivity of dried fruits and honey of Ficus carica cultivars Dottato, San Francesco, and Citrullara by Loizzo MR1, Bonesi M, Pugliese A, Menichini F, Tundis R.(PubMed)
(2) Ficus carica leaf extract modulates the lipid profile of rats fed with a high-fat diet through an increase of HDL-C by Joerin L1, Kauschka M, Bonnländer B, Pischel I, Benedek B, Butterweck V.(PubMed)
(3) Effect of ether- and water-soluble fractions of Carica papaya ethanol extract in experimentally induced hyperlipidemia in rats by Iyer D1, Sharma BK, Patil UK. (PubMed)

#Organic Growing Pepers Show Higher Level of Antioxidant Compounds Compared to Conventional Cultivated, Studies Suggest

Kyle J. Norton

Herbal Cayenne may have a potential effect in stimulating the production of antioxidants from the host body to inhibit the overexpression of free radicals, some scientists suggested.

Free radicals are unstable molecules having an unpaired electron in the outer ring. in order for them to maintain stability, free radicals must donate or steal an electron from another molecule, leading to a domino's chain reaction that cannot stop until inhibited by antioxidants or they are paired.

Antioxidants are stable molecules that inhibit free radical oxidation and the unpaired electrons which are highly and chemically reactive in the human body.

Normally, the expression of free radicals is neutralized by antioxidants produced by the host body enzymes. However, if the host antioxidant enzymes are suppressed, the free radicals can overexpress, leading to oxidative stress.

Overexpression of free radicals in initiating oxidative stress to the human body can cause oxidative damage to the cells, proteins, and DNA, the underlying factors in many chronic diseases, including type 2 diabetes, and cardiovascular disease.

The most common free radicals that have been found to cause significant damage to DNA, proteins, carbohydrates, and lipids of the cell nucleus, and membranes are hydroxyl radical, superoxide anion radical, hydrogen peroxide, oxygen singlet, hypochlorite, nitric oxide radical, peroxynitrite radical.

The causes of the production of free radicals are associated either with normal essential metabolic processes in the human body inducing diet or from external sources such as exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals.

People who follow the Western diet high in saturated and trans fat, red meat, and processed foods ( high oxidation) and low in fruits and vegetables (low antioxidants) are susceptible to the overexpression of free radicals or oxidative stress.

Truly, Fats and oils not can be oxidized during storage as a result of exposure to light, and air but also can become oxidized, creating free radicals, if they are heated in high temperatures, the main cooking style found in the Western diet.


Saturated fats are less likely than unsaturated fats to become oxidized. When cooking fats are reused, they become more oxidized and produce even more free radicals.

Cayenne is also known as Cayenne pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.

The kitchen spice has been used in traditional medicine to increase metabolism, enhance the circulatory system and stomach and intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.

The chemical constituents of Cayenne include capsaicin, capsaicin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.

In the investigation of the antioxidant activity, DPPH radical-scavenging activity correlated with total bioactive compounds (capsaicinoids, carotenoids, flavonoids, and total phenolics) in pepper cultivars, researchers at the Universidad Complutense de Madrid launched a study on the individual carotenoid and phenolic content as well as the antioxidant properties of four red-hot dried cultivars (Capsicum annuum L.).

Hot dried peppers at the ripe stage demonstrated a high content of bioactive compounds that exhibited significant antioxidant properties (26-80 micromol Trolox equivalents/g of dry matter), compared to polyphenols >2000 mg/100 g of dry matter and carotenoids ranging from 95-437 mg/100 g of dry matter.

The amount released from the food matrix by the action of digestive enzymes was about 75% for total polyphenols, up to 49% for both beta-carotene and zeaxanthin and up to 41% for beta-cryptoxanthin.

And, 50 to 80% of these carotenoids could reach the colon to be potentially fermented or could remain unavailable.

Furthermore, in the study of sweet red bell pepper, one of the best sources of ascorbic acid and carotenoids and phenolic compounds important in the human diet, researchers emphasized that organic growing increased the level of antioxidant compounds such as carotenoids, phenolic compounds, and vitamin C in sweet bell pepper, compared to conventional cultivated.


However, the second significant factor affecting the antioxidant compound content of sweet bell pepper was totally dependent on the varieties.

Geography, climate change environmental factors, and time of harvest may also affect the antioxidant contents of the bell pepper.

Taken altogether, herbal cayenne processed with a high amount of bioactive antioxidants may be considered a functional food for reducing the risk of oxidative stress-related diseases.


Due to number of unknown factors that may affect the quality of the fruits, further data collection large example size, and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of herbal cayenne antioxidant possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Bioactive compounds of four hot pepper varieties (Capsicum annuum L.), antioxidant capacity, and intestinal bioaccessibility by Hervert-Hernández D1, Sáyago-Ayerdi SG, Goñi I.(PubMed)
(2) Characterisation of antioxidant compounds in sweet bell pepper (Capsicum annuum L.) under organic and conventional growing systems by Hallmann E1, Rembiałkowska E.(PubMed)

#Cucumber's Cucurbitacin B (CuB) Inhibits Anti Chronic Myeloid #Leukaemia by Activating protein associated with Cell Death Programming, Researchers Say

Kyle J. Norton

Chronic myeloid leukemia (CML) also known as chronic myelogenous leukemia is a type of leukemia associated with certain blood-forming cells of the bone marrow.
Chronic myeloid leukemia (CML) is slow-growing cancer compared to the acute forms of leukemia.

In the US, most cases of chronic myelogenous leukemia are found in adults aged of 65 and older.

According to the American Cancer Society, approximately, 8,990 new cases will be diagnosed with CML (5,250 in men and 3,740 in women) in 2019. CML also will cause the death of 1,140 patients (660 men and 480 women) in the same year.

The lifetime risk of CML is 1 in 526 in the United States.

CML besides sharing the common symptoms of other types of cancer, the condition also induces symptoms of easy bleeding, pain or fullness below the ribs on the left side, pale skin, and sweating excessively during sleep (night sweats).

If you are experiencing some of the aforementioned symptoms, please check with your doctor to rule out the possibility.

Today, due to new drug discoveries and improvements in technology, the 5-year survival rate for CML is 68% compared to only 31% in the early 1990s.

Out of many risk factors such as radiotherapy, gender, and aging, some researchers suggested that obesity may be one of the main factors that elevated the risk of the disease.

Dr. Strom SS, the lead researchers in the cancer team at the University of Texas M. D. Anderson Cancer Center wrote, " Obesity, measured as body mass index, has been identified as a possible risk factor for several solid tumors as well as some adult hematopoietic malignancies".

And, "Obesity at all ages was found to be an independent risk factor, with a significant dose-response effect. Among participants > or =45 years, cases gained significantly more weight each year between ages 25 and 40 compared with controls (0.78 versus 0.44 kg/y, P < 0.001) with the association strongest among those who gained >1 kg/y between 25 and 40 years of age (OR, 3.63; 95% CI, 1.46-9.04). Our results suggest that obesity and adulthood weight gain play important roles in CML risk".

The findings strongly suggested that obese are more likely to develop CML, compared to those with normal weight.

The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

On finding a natural and potential compound for the treatment of chronic myeloid leukemia, researchers examined the Cucurbitacin B (CuB) antiproliferative effects on various leukemia cell lines.


Administration of CuB showed strong inhibition against various leukemia, lymphoma cell lines, and primary mononuclear bone marrow cells derived from patients with acute myeloid leukemia or myelodysplastic syndrome.

CuB induced myeloid leukemic cells apoptosis through S-phase cell cycle arrest, enlarged cell size, multinucleation, and enhanced expression of a monocytic- and granulocytic-specific CD11b involved in numerous adhesion-related associations between cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes.

Furthermore, CuB prominently altered the cytoskeletal network of leukemic cells, leading to cell death.

In order to obtain additional information about cucurbitacin B (CuB) anti-myeloid leukemia activity, researchers explored the antitumor effect and action mechanism of cucurbitacin B (CuB) on human T-cell leukemia Jurkat cells.

According to the tested assays, CuB inhibited the proliferation of Jurkat cells in a dose-dependent manner and induced G 2 /M phase arrest.

CuB induced around 10% of cells undergoing apoptosis, after treatment for 24 h.

Moreover, CuB induced cancer cell autophagy was observed by the accumulation of LC3-II, an indication of cleaning out damaged cells and regenerating new ones.

Taken altogether, cucumber processed with a higher number of CuB may be used for the treatment of leukemia, pending the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells by Haritunians T1, Gueller S, Zhang L, Badr R, Yin D, Xing H, Fung MC, Koeffler HP. (PubMed)
(2) Cucurbitacin B induces cell cycle arrest, apoptosis and autophagy associated with G actin reduction and persistent activation of cofilin in Jurkat cells by Zhu JS1, Ouyang DY, Shi ZJ, Xu LH, Zhang YT, He XH. (PubMed)
(3) Obesity, weight gain, and risk of chronic myeloid leukemia by Strom SS1, Yamamura Y, Kantarijian HM, Cortes-Franco JE. (PubMeb)

#Phytochemical #Alliin Improves the Gut Immunity through their Anti-Inflammatory and Anti-Free Radical Activities, According to Studies

Kyle J. Norton

Gut microbiota refers to the population of microbes living in the gut. The community contains tens of trillions of microorganisms with over 1000 different species of bacteria.

The gut microbiota plays a vital role in human health, including the key processes of nutrition-enhancing the digestive functioning, lipid, and energy metabolism by inducing the production of short-chain fatty acids (SCFAs), phenolics, and other molecules, and pathogen resistance by promoting the immune function.

In a healthy individual, the levels of gut microbiota are balanced which allows the body to funoptimallyal way.

Furthermore, gut microbiota also is found to stimulate the production of some vitamins (B and K), and digest certain foods that the stomach and small intestine have not been able to digest, particularly in the combat against the aggression of other bad microorganisms.


However, alterations in gut microbiota composition have been found in patients with a low-grade inflammatory state, leading to an increased risk of several diseases, including type 2 diabetes mellitus and cardiovascular disease.

Although the digestive tract can adapt to change, the loss of balance in gut microbiota may induce dysbiosis., leading to health problems of functional bowel disorders, inflammatory bowel disease, allergies, obesity, and diabetes.

The are many risk factors associated with gut microbiota imbalance. Some researchers suggested that the major causes of the condition may be a result of the promotion of a high-fat diet over the past few decades.

Dr. Duo Li, at the Institute of Nutrition and Health at Qingdao University in China, and colleagues wrote, "“Western-type diet has a strong effect on the genetic composition and metabolic activity of gut microbiota,” they wrote. “Evidence has shown that in humans gut microbiota diversity and richness are reduced when comparing such high-fat diets with more traditional diets with relatively higher proportions of carbohydrates. Such diet-induced ‘dysbiosis’ in gut-associated microbial communities has been postulated as a major trigger of metabolic impairments associated with obesity".

Alliin (S-allyl-L-cysteine-S-oxour intestinal chemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onToaim to find a natural ingredient with immunomodulatory activity, researchers examined the effect of the garlic derivative alliin, on the mitogen-induced peripheral blood mononuclear cell (PBMC) proliferation and cytokine production in vitro.


Before being treated with garlic derivative alliin, pokeweed mitogen (PWM) injection induced cell proliferation, and production of proinflammatory cytokines, including IL-1beta and TNF-alpha.

Furthermore, the pokeweed mitogen (PWM) treated group also showed reduced levels of both percentage of phagocyting cells and the number of latex particles associated with the immune functions of phagocytosis.

Administration of garlic derivative alliin not decreased only the production of proinflammatory cytokines induced by pokeweed mitogen (PWM) but also improved the levels of antioxidant enzymes.

In other words, alliin exerted an immunomodulatory effect on the peripheral blood cells in vitro.

In finding a natural compound for the improvement of the ratio of gut microbiota, researchers examined whether different plant-derived components with similar anti-oxidative and anti-inflammatory functions such as quercetin and alliin in traditional Asian diet on the status of the gut microbiota and colonic epithelial immunity.

Traditional Asian diet significantly increased reshaped the gut microbiota composition by significantly increasing the relative abundance of fecal Firmicutes and Cyanobacteria but decreased that of Bacteroidetes (P < 0.05) and increasing the relative abundance of Candidatus Arthromitus, Lactococcus, Geobacillus, and Ruminococcus at the genus level that benefits the host's health.

In other words, the traditional Asian diet reduced the expression of bad bacteria and increased the good bacteria in the gut.

The consumption of quercetin and alliin also altered 13 genes expression involved in the KEGG pathways' immunomodulatory effect in improving gut immunity through their anti-inflammatory and anti-free radical activities.

In other words, the alternate consumption of quercetin and alliin can contribute to beneficial metabolic effects by optimizing gut microbiota by improving the immunologic function of colonic epithelial cells associated with the innate immune defense.

Taken altogether, alliin may be considered a supplement for the improvement of gut microbiota inducing immunologic function of colonic epithelial cells associated with the innate immune defense, pending the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) The Alternate Consumption of Quercetin and Alliin in the Traditional Asian Diet Reshaped Microbiota and Altered Gene Expression of Colonic Epithelial Cells in Rats by Yu J1, Guo H1, Xie J1, Luo J1, Li Y1, Liu L1, Ou S1, Zhang G1, Peng X. (PubMed)
(2) High-fat diet linked to unfavorable gut microbiota changes by Wan Y. (Healio Gastroenterology)