Kyle J. Norton
Herbal Arctostaphylos uva-ursi may have a potential effect in reducing the risk and treatment of oxidative stress-related diseases, some studies suggested.
Oxidative stress is a production of the imbalance of the ratio of free radicals and antioxidants in the bost body.
The imbalance of the ratio of free radicals and antioxidants in the bost body can be caused either by the overproduction of free radicals or antioxidant enzymes suppressed by outside sources.
However, most outside sources that suppress the levels of antioxidant enzymes also play an important role in stimulating the overexpression of free radicals, such as chemical toxins
Free radicals are unstable atoms with the unpaired electron in the outer ring. Therefore, in order for them to become stable, free radical either donates or steals an electron from stable molecules, leading to a chain of reaction that facilitates the onset of oxidative stress.
The chain once starts, it can not stop until the electron on the outer ring is paired or inhibited by the antioxidant.
A free radical has been known to cause oxidative damage to enzymes, other protein, unsaturated fatty acid, phospholipids, DNA and RNA.
Antioxidants are stable molecules found abundantly in fruits, vegetables, and herbal medicine.
If oxidative stress-related diseases are associated with the overproduction of free radicals, then long-term intake of a healthy diet high in fruits, vegetables and less in red meat and saturated and trans fat and processed foods can reduce the risk of the diseases in healthy individuals.
Dr. Halliwell B, in the study to reaffirm the effect of healthy dietary patterns against the onset of oxidative stress, said, " diet-derived antioxidants may be particularly important in protecting against these diseases" and
"The physiological relevance of these effects is uncertain, as is the optimal intake of most diet-derived antioxidants. In principle, these questions could be addressed by examining the effects of dietary composition and/or antioxidant supplementation upon parameters of oxidative damage in vivo".
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.
The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infections, kidney stones, pelvic pain, etc.
The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
In examining Dr. Bol'shakova IV, the lead author at the Emanuel Institute of Biochemical Physics claim, that Arctostaphylos uva.processes a significant antioxidant property in the inhibition of free radicals generation, researchers launched an investigation to evaluate the concentration of compound that inhibited cell growth by 50% (IC(50)) of a range of phytochemicals and plant extracts.
All selected extracts were differentiated according to the antioxidant and renoprotective effects under conditions of oxidative stress in U937 cells.
Two phytochemicals-resveratrol and citroflavan-3-ol isolated from the herbal Arctostaphylos uva-ursi demonstrated the highest IC50 value of 13.7 microg/mL, compared to the lowest at 9,400 microg/mL. of Echinacea.
Extract of herbal Arctostaphylos uva-ursi displayed a significant attenuation of the oxidative stress induced by the etoposide injection by inhibiting the expression of H2O2- and tBOOH-induced DNA damage.
These results reconfirmed the findings of Dr. Bol'shakova IV team that herbal Arctostaphylos uva-ursi as a non-nutrient dietary constituent may act as significant bioactive compounds in enhancing the antioxidants activity and stimulating the production of antioxidant enzymes if the herb is administrated in an animal model.
Moreover, Dr.Matsuda H the antioxidant team leader at Kinki University, Osaka in the finding the natural compounds or whole food with potential antioxidant effects evaluated the inhibitory effect of 50% ethanol extracts obtained from the leaves of six Arctostaphylos plants (A. patula, A. viscida, A. canescens, A. Columbiana, A. nevadensis and A. uva-ursi) (Ericaceae).
Injection of the extracts of A. patula showed potent inhibition against tyrosinase, the enzyme that causes oxidation of the skin pigment.
Also, Arctostaphylos uva-ursi not only inhibited the production of melanin from dopachrome by autoxidation but reduced the over-exhibited SOD (superoxide dismutase, free radical)-like activity.
Additionally, Arctostaphylos uva-ursi processed a moderate absorbance in the UV-B area.
The results not only reaffirm the claim of Dr. Bol'shakova IV's suggestion but also introduce a new herbal whitening medicine for the skin.
Taken together, Herbal Arctostaphylos uva-ursi may be considered a functional food for the prevention and an adjunct therapy combine with primary medicine for the treatment of oxidative-related diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Antioxidant properties of plant extracts].[Article in Russian] by Bol'shakova IV, Lozovskaia EL, Sapezhinskiĭ II. (PubMed)
(2) Modulatory effects of resveratrol, citroflavan-3-ol, and plant-derived extracts on oxidative stress in U937 cells by O'Brien NM, Carpenter R, O'Callaghan YC, O'Grady MN, Kerry JP. (PubMed)
(3) Studies of cuticle drugs from natural sources. IV. Inhibitory effects of some Arctostaphylos plants on melanin biosynthesis. by Matsuda H, Higashino M, Nakai Y, Iinuma M, Kubo M, Lang FA. (PubMed)
Wednesday, 28 June 2023
#Phytochemical 3,3'-Diindolylmethane DIM Reduces #PancreaticCancer Cell Viability and Caused Cell Growth Inhibition and Apoptosis, Researchers Say
Kyle J. Norton
Pancreatic cancer is a medical condition characterized by irregular cell growth in the tissue of the pancreas.
Most cases of pancreatic cancer start in the cell on the surface of the inner lining of the pancreatic tissue, before penetrating into the deeper layers to form a large and invasive tumor.
At the early stage, patients with pancreatic cancer may be asymptomatic. However, at the later stage, besides the common symptoms shared by all types of cancer such as unintended weight loss, loss of appetite, fatigue, and gastrointestinal discomforts, patients with the condition may also experience localized symptoms such as internal bleeding and severe pain due to the oversize tumor which suppresses the nerve cells and blood vessels.
According to the statistic, in the US, every year, approximately 55,440 adults (29,200 men and 26,240 women) are diagnosed with pancreatic cancer.
The 5-year survival rate including all stages of people with pancreatic cancer is 8%, compared to 32% of cancer detected at an early stage.
The exact causes of pancreatic cancer are identified. However, epidemiological studies suggested that the increase in age, family history, race, gender, smoking, being obese or overweight and a medical condition such as diabetes is the most prevalent risk of the disease.
Some researchers indicated that genetic preposition may have a strong implication in the initiation of the onset of pancreatic cancer.
Dr. Alison P. Klein wrote, "These consist of high penetrance genes including BRCA2 or PALB2, to more common genetic variation associated with a modest increase risk of pancreatic cancer such as genetic variation at the ABO blood group locus".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In finding a bioactive ingredient for the treatment of pancreatic cancer, researchers investigated the 3,3'-Diindolylmethane (DIM), ring-substituted DIMs, and 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl) methanes (C-DIMs) against the growth of Panc-1 and Panc-28 pancreatic cancer cells.
According to assays, Both DIM and DIM-C-pPhtBu induced pancreatic cancer cells. apoptosis observed by the increased endoplasmic reticulum (ER) staining and ER calcium release in Panc-1 cells.
Glucose-regulated protein 78, a protein in the endoplasmic reticulum in the cell played an important role in cellular adaptation and oncogenic survival also increased by the injection of both DIM and DIM-C-pPhtBu.
Furthermore, both DIM and DIM-C-pPhtBu. also exerted a significant activity against the pancreatic cancer cells through increasing the C/EBP homologous transcription factor in the regulation of cells apoptosis in response to cellular oxidative stress, similar to those of thapsigargin (Tg).
Moreover, DIM/DIM-C-pPhtBu- and Tg-induced ER stress in facilitating pancreatic cancer cell death through cell death receptors and proteins associated with programming cell death.
Dr. the lead scientists after taking into account co and confounders wrote in the final report, "Activation of both receptor-dependent and receptor-independent (ER stress) pathways by DIM and DIM-C-pPhtBu in pancreatic cancer cells enhances the efficacy and potential clinical importance of these compounds for cancer chemotherapeutic applications".
Additionally, in order to reveal more information about DIM-induced pancreatic cancer cell apoptosis, researchers analyzed the DIM effect by examing the process through multiple molecular assays.
According to the Western blot analysis, 3,3'-diindolylmethane (DIM) a chemopreventive agent, specifically its more bioavailable formulation, B-DIM, inhibited Par-4, in L3.6pl and Colo-357 pancreatic cancer cells at low doses (20 micromol/L).
At similar doses, DIM reduced cell viability and caused cell growth inhibition and apoptosis.
Also, pretreatment of DIM sensitized the cells to the cytotoxic action of the chemotherapeutic drug gemcitabine.
In other words, DIM not only processed anti-pancreatic cancer cells proliferation and induced apoptosis but also promoted the chemotherapeutic drug cytotoxic activity against pancreatic cancer cells.
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of pancreatic cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5,Abdelrahim M1, Newman K, Vanderlaag K, Samudio I, Safe S. (PubMed)
(2) Chemoprevention of pancreatic cancer: characterization of Par-4 and its modulation by 3,3' diindolylmethane (DIM) by Azmi AS1, Ahmad A, Banerjee S, Rangnekar VM, Mohammad RM, Sarkar FH. (PubMed)
(3) Genetic Susceptibility to Pancreatic Cancer by Alison P. Klein. (PMC)
Pancreatic cancer is a medical condition characterized by irregular cell growth in the tissue of the pancreas.
Most cases of pancreatic cancer start in the cell on the surface of the inner lining of the pancreatic tissue, before penetrating into the deeper layers to form a large and invasive tumor.
At the early stage, patients with pancreatic cancer may be asymptomatic. However, at the later stage, besides the common symptoms shared by all types of cancer such as unintended weight loss, loss of appetite, fatigue, and gastrointestinal discomforts, patients with the condition may also experience localized symptoms such as internal bleeding and severe pain due to the oversize tumor which suppresses the nerve cells and blood vessels.
According to the statistic, in the US, every year, approximately 55,440 adults (29,200 men and 26,240 women) are diagnosed with pancreatic cancer.
The 5-year survival rate including all stages of people with pancreatic cancer is 8%, compared to 32% of cancer detected at an early stage.
The exact causes of pancreatic cancer are identified. However, epidemiological studies suggested that the increase in age, family history, race, gender, smoking, being obese or overweight and a medical condition such as diabetes is the most prevalent risk of the disease.
Some researchers indicated that genetic preposition may have a strong implication in the initiation of the onset of pancreatic cancer.
Dr. Alison P. Klein wrote, "These consist of high penetrance genes including BRCA2 or PALB2, to more common genetic variation associated with a modest increase risk of pancreatic cancer such as genetic variation at the ABO blood group locus".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In finding a bioactive ingredient for the treatment of pancreatic cancer, researchers investigated the 3,3'-Diindolylmethane (DIM), ring-substituted DIMs, and 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl) methanes (C-DIMs) against the growth of Panc-1 and Panc-28 pancreatic cancer cells.
According to assays, Both DIM and DIM-C-pPhtBu induced pancreatic cancer cells. apoptosis observed by the increased endoplasmic reticulum (ER) staining and ER calcium release in Panc-1 cells.
Glucose-regulated protein 78, a protein in the endoplasmic reticulum in the cell played an important role in cellular adaptation and oncogenic survival also increased by the injection of both DIM and DIM-C-pPhtBu.
Furthermore, both DIM and DIM-C-pPhtBu. also exerted a significant activity against the pancreatic cancer cells through increasing the C/EBP homologous transcription factor in the regulation of cells apoptosis in response to cellular oxidative stress, similar to those of thapsigargin (Tg).
Moreover, DIM/DIM-C-pPhtBu- and Tg-induced ER stress in facilitating pancreatic cancer cell death through cell death receptors and proteins associated with programming cell death.
Dr. the lead scientists after taking into account co and confounders wrote in the final report, "Activation of both receptor-dependent and receptor-independent (ER stress) pathways by DIM and DIM-C-pPhtBu in pancreatic cancer cells enhances the efficacy and potential clinical importance of these compounds for cancer chemotherapeutic applications".
Additionally, in order to reveal more information about DIM-induced pancreatic cancer cell apoptosis, researchers analyzed the DIM effect by examing the process through multiple molecular assays.
According to the Western blot analysis, 3,3'-diindolylmethane (DIM) a chemopreventive agent, specifically its more bioavailable formulation, B-DIM, inhibited Par-4, in L3.6pl and Colo-357 pancreatic cancer cells at low doses (20 micromol/L).
At similar doses, DIM reduced cell viability and caused cell growth inhibition and apoptosis.
Also, pretreatment of DIM sensitized the cells to the cytotoxic action of the chemotherapeutic drug gemcitabine.
In other words, DIM not only processed anti-pancreatic cancer cells proliferation and induced apoptosis but also promoted the chemotherapeutic drug cytotoxic activity against pancreatic cancer cells.
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of pancreatic cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5,Abdelrahim M1, Newman K, Vanderlaag K, Samudio I, Safe S. (PubMed)
(2) Chemoprevention of pancreatic cancer: characterization of Par-4 and its modulation by 3,3' diindolylmethane (DIM) by Azmi AS1, Ahmad A, Banerjee S, Rangnekar VM, Mohammad RM, Sarkar FH. (PubMed)
(3) Genetic Susceptibility to Pancreatic Cancer by Alison P. Klein. (PMC)
#CarrotsJuice Protects the #CardiovascularSystem by Increasing Total Antioxidant Status and Decreasing Lipid Peroxidation
Kyle J. Norton
Carrots may process a potential effect in reducing the risk and treatment of cardiovascular disease through their antioxidant in inhibitory lipid peroxidation, some researchers suggested.
Cardiovascular disease (CVD) is a group of medical conditions associated with the damage of the heart and blood vessels, including atherosclerosis, heart failure, and stroke.
The exact causes of cardiovascular disease are unknown. Researchers suggested that there are a number of factors associated with the early onset of the disease, including being overweight, lack of physical inactivity, poor nutrition, and smoking.
Some researchers also considered some psychological factors such as depression are some prevalent risk factors that cause cardiovascular disease.
Dr. Everson-Rose SA, the lead author in the study "Psychosocial factors and cardiovascular diseases" suggested, "(a) negative emotional states, including depression, anger, hostility, and anxiety; (b) chronic and acute psychosocial stressors; and (c) social ties, social support, and social conflict are associated with cardiovascular disease, morbidity, and mortality.
Additionally, genetic preposition, unhealthy diet, and lifestyle also play an important role in the increased risk of cardiovascular disease.
The study by Dr. Edward Yu, the lead scientist wrote, "Diets low in trans fat, saturated fat, refined carbohydrates, and sugar-sweetened beverages and rich in fruits and vegetables, whole grains, and sources of unsaturated fats are associated with reduced risk of cardiovascular disease. Healthy lifestyle choices include smoking avoidance, regular physical activity, maintaining a normal body mass index, and moderate alcohol consumption. Adherence to a combination of these healthy diet and lifestyle behaviors may prevent most vascular events".
These results firmly suggested people who follow a Western diet high in bad fats, processed and junk food, and low in fruits and vegetables are at a higher risk of CVD.
Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asia and Europe.
In the concerns of the high prevalence of obesity and cardiovascular disease is attributable to a sedentary lifestyle and eating diets high in fat and refined carbohydrates while eating diets low in fruit and vegetables, researchers launched an investigation to examine the effect of carrot juice in the reduced risk of CVD.
The assessment of the study includes the calculation of the effects of consuming 16 fl oz of daily freshly squeezed carrot juice for three months on cardiovascular risk markers, such as C-reactive protein, insulin, leptin, interleukin-1α, body fat percentage, body mass index (BMI), blood pressure, antioxidant status, and malondialdehyde production.
Although drinking carrot juice did not affect the plasma cholesterol, triglycerides, Apo A, Apo B, LDL, HDL, body fat percentage, insulin, leptin, interleukin-1α, or C-reactive protein, the juice, however, decreased systolic pressure but did not influence diastolic pressure.
Further analysis also indicated drinking carrot juice significantly increased the plasma total antioxidant capacity and decreased the plasma malondialdehyde production.
In other words, carrot juice has a significant effect in reducing the risk of oxidative stress by balancing the ratio of levels of antioxidants/free radicals in the body, the major cause of CVD.
Dr. Potter AS, the lead scientist said, "Drinking carrot juice may protect the cardiovascular system by increasing total antioxidant status and by decreasing lipid peroxidation independent of any of the cardiovascular risk markers".
Interestingly, in the examine whether Anthocyanins, phenolic acids, and carotenoids are the predominant phytochemicals present in purple carrots, have beneficial effects in preventing metabolic syndrome, a prevalent risk factor of cardiovascular disease, The University of Queensland conducted a study in the animal models.
Purple carrot juice attenuated or reversed all changes while β-carotene did not reduce oxidative stress, cardiac stiffness, or hepatic fat deposition.
After taking into account co and confound, the researchers suggested that the anthocyanins, the major bioactive compound from purple carrot are responsible for the antioxidant and anti-inflammatory properties that improve glucose tolerance as well as the cardiovascular and hepatic structure and function.
Taken altogether, purple carrot and non-purple carrot juice with high amounts of antioxidants may be considered functional drinks for the prevention and treatment of cardiovascular disease.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Drinking carrot juice increases total antioxidant status and decreases lipid peroxidation in adults.
Potter AS1, Foroudi S, Stamatikos A, Patil BS, Deyhim F.(PubMed)
(2) Moderate intervention with carotenoid-rich vegetable products reduces lipid peroxidation in men By Bub A1, Watzl B, Abrahamse L, Delincée H, Adam S, Wever J, Müller H, Rechkemmer G. (PubMed)
(3) Psychosocial factors and cardiovascular diseases by Everson-Rose SA1, Lewis TT. (PubMed)
Carrots may process a potential effect in reducing the risk and treatment of cardiovascular disease through their antioxidant in inhibitory lipid peroxidation, some researchers suggested.
Cardiovascular disease (CVD) is a group of medical conditions associated with the damage of the heart and blood vessels, including atherosclerosis, heart failure, and stroke.
The exact causes of cardiovascular disease are unknown. Researchers suggested that there are a number of factors associated with the early onset of the disease, including being overweight, lack of physical inactivity, poor nutrition, and smoking.
Some researchers also considered some psychological factors such as depression are some prevalent risk factors that cause cardiovascular disease.
Dr. Everson-Rose SA, the lead author in the study "Psychosocial factors and cardiovascular diseases" suggested, "(a) negative emotional states, including depression, anger, hostility, and anxiety; (b) chronic and acute psychosocial stressors; and (c) social ties, social support, and social conflict are associated with cardiovascular disease, morbidity, and mortality.
Additionally, genetic preposition, unhealthy diet, and lifestyle also play an important role in the increased risk of cardiovascular disease.
The study by Dr. Edward Yu, the lead scientist wrote, "Diets low in trans fat, saturated fat, refined carbohydrates, and sugar-sweetened beverages and rich in fruits and vegetables, whole grains, and sources of unsaturated fats are associated with reduced risk of cardiovascular disease. Healthy lifestyle choices include smoking avoidance, regular physical activity, maintaining a normal body mass index, and moderate alcohol consumption. Adherence to a combination of these healthy diet and lifestyle behaviors may prevent most vascular events".
These results firmly suggested people who follow a Western diet high in bad fats, processed and junk food, and low in fruits and vegetables are at a higher risk of CVD.
Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belonging to the family Apiaceae, native to Asia and Europe.
In the concerns of the high prevalence of obesity and cardiovascular disease is attributable to a sedentary lifestyle and eating diets high in fat and refined carbohydrates while eating diets low in fruit and vegetables, researchers launched an investigation to examine the effect of carrot juice in the reduced risk of CVD.
The assessment of the study includes the calculation of the effects of consuming 16 fl oz of daily freshly squeezed carrot juice for three months on cardiovascular risk markers, such as C-reactive protein, insulin, leptin, interleukin-1α, body fat percentage, body mass index (BMI), blood pressure, antioxidant status, and malondialdehyde production.
Although drinking carrot juice did not affect the plasma cholesterol, triglycerides, Apo A, Apo B, LDL, HDL, body fat percentage, insulin, leptin, interleukin-1α, or C-reactive protein, the juice, however, decreased systolic pressure but did not influence diastolic pressure.
Further analysis also indicated drinking carrot juice significantly increased the plasma total antioxidant capacity and decreased the plasma malondialdehyde production.
In other words, carrot juice has a significant effect in reducing the risk of oxidative stress by balancing the ratio of levels of antioxidants/free radicals in the body, the major cause of CVD.
Dr. Potter AS, the lead scientist said, "Drinking carrot juice may protect the cardiovascular system by increasing total antioxidant status and by decreasing lipid peroxidation independent of any of the cardiovascular risk markers".
Interestingly, in the examine whether Anthocyanins, phenolic acids, and carotenoids are the predominant phytochemicals present in purple carrots, have beneficial effects in preventing metabolic syndrome, a prevalent risk factor of cardiovascular disease, The University of Queensland conducted a study in the animal models.
Purple carrot juice attenuated or reversed all changes while β-carotene did not reduce oxidative stress, cardiac stiffness, or hepatic fat deposition.
After taking into account co and confound, the researchers suggested that the anthocyanins, the major bioactive compound from purple carrot are responsible for the antioxidant and anti-inflammatory properties that improve glucose tolerance as well as the cardiovascular and hepatic structure and function.
Taken altogether, purple carrot and non-purple carrot juice with high amounts of antioxidants may be considered functional drinks for the prevention and treatment of cardiovascular disease.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Drinking carrot juice increases total antioxidant status and decreases lipid peroxidation in adults.
Potter AS1, Foroudi S, Stamatikos A, Patil BS, Deyhim F.(PubMed)
(2) Moderate intervention with carotenoid-rich vegetable products reduces lipid peroxidation in men By Bub A1, Watzl B, Abrahamse L, Delincée H, Adam S, Wever J, Müller H, Rechkemmer G. (PubMed)
(3) Psychosocial factors and cardiovascular diseases by Everson-Rose SA1, Lewis TT. (PubMed)
#Honey Containing #Chrysin Inhibits the ProinflammatoryCytokiens Against the Onset of #Osteoarthritis, Researchers Find
Kyle J. Norton
In seeking natural therapy with no side effects, scientists may have a herbal remedy for the prevention and treatment of osteoarthritis, according to studies.
Osteoarthritis (OA) is a common chronic inflammatory joint disease characterized by the breaking down of joint cartilage and the underlying bone.
Genetic preposition, overweight, and obesity, injury, and overuse of the joints are the most common risk factor associated with the onset of the disease.
Occupation with the repetitive movements of the joint is most affected by the disease.
Interestingly, osteoarthritis symptoms can come and go throughout the day and vary from person to person. Weather change has been one of the most complaints that trigger the symptoms of OA in the elderly.
The most common symptoms, according to epidemiological studies include joint pain, tenderness, and lack of flexibility and stiffness.
Some osteoporotic patient may also experience symptoms of grating sensation and bone spurs.
If you experience some of the above symptoms, you may have osteoarthritis.
Some researchers suggested that obesity may be one of the major risk factors besides the occupation with repetitive movement of osteoarthritis in the Western world.
Dr. Lauren K. King, the lead scientists in the investigation of obesity & osteoarthritis, wrote, "The most significant impact of obesity on the musculoskeletal system is associated with osteoarthritis (OA), a disabling degenerative joint disorder characterized by pain, decreased mobility and negative impact on quality of life".
And, "Obesity is associated with the incidence and progression of OA of both weight-bearing and non-weight-bearing joints, to rate of joint replacements as well as operative complications".
The finding strongly indicated the risk of osteoarthritis is increased by many folds in the obese population, compared to those with a healthy weight.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of the healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In the concerns of widespread osteoarthritis (OA), a chronic degenerative joint disease, researchers investigated chrysin, a natural flavonoid extracted from honey, and propolis anti-inflammatory effects.
The study included human OA chondrocytes pretreated with chrysin (1, 5, 10 μM) for 2 h and subsequently stimulated with IL-1β, an inflammatory cytokine for 24 h.
Injection of chrysin exerted a strong inhibition activity against the degradation of aggrecan and collagen-II.
Chrysin significantly inhibited the IL-1β-induced production inflammatory cytokines such as degradation of c of NO and PGE2; expression of COX-2, iNOS.
Futhermore, chrysin also reduced the expression of matrixes such as MMP-1, MMP-3, MMP-13 and enzymes ADAMTS-4, and ADAMTS-5 associated with the progression and destruction of joint in early osteoarthritis.
In the depth analysis researchers also found that chrysin dramatically blocked IL-1β-stimulated IκB-α degradation in the activation of protein NF-κB-induced production of proinflammatory cytokines.
The results suggested that chrysin inhibits the progression of OA through several mechanisms, including enzymes and proteins involving the destruction of joint tissues.
Taken altogether, honey processed a bioactive compound chrysin may be considered a functional remedy for the prevention and treatment of OA, with no side effects, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chrysin Attenuates IL-1β-Induced Expression of Inflammatory Mediators by Suppressing NF-κB in Human Osteoarthritis Chondrocytes by Zheng W1, Tao Z1, Cai L1, Chen C1, Zhang C1, Wang Q1, Ying X1, Hu W1, Chen H2. (PubMed)
(2) Obesity & osteoarthritis by Lauren K. King,* Lyn March,** and Ananthila Anandacoomarasamy. (PMC)
In seeking natural therapy with no side effects, scientists may have a herbal remedy for the prevention and treatment of osteoarthritis, according to studies.
Osteoarthritis (OA) is a common chronic inflammatory joint disease characterized by the breaking down of joint cartilage and the underlying bone.
Genetic preposition, overweight, and obesity, injury, and overuse of the joints are the most common risk factor associated with the onset of the disease.
Occupation with the repetitive movements of the joint is most affected by the disease.
Interestingly, osteoarthritis symptoms can come and go throughout the day and vary from person to person. Weather change has been one of the most complaints that trigger the symptoms of OA in the elderly.
The most common symptoms, according to epidemiological studies include joint pain, tenderness, and lack of flexibility and stiffness.
Some osteoporotic patient may also experience symptoms of grating sensation and bone spurs.
If you experience some of the above symptoms, you may have osteoarthritis.
Some researchers suggested that obesity may be one of the major risk factors besides the occupation with repetitive movement of osteoarthritis in the Western world.
Dr. Lauren K. King, the lead scientists in the investigation of obesity & osteoarthritis, wrote, "The most significant impact of obesity on the musculoskeletal system is associated with osteoarthritis (OA), a disabling degenerative joint disorder characterized by pain, decreased mobility and negative impact on quality of life".
And, "Obesity is associated with the incidence and progression of OA of both weight-bearing and non-weight-bearing joints, to rate of joint replacements as well as operative complications".
The finding strongly indicated the risk of osteoarthritis is increased by many folds in the obese population, compared to those with a healthy weight.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of the healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In the concerns of widespread osteoarthritis (OA), a chronic degenerative joint disease, researchers investigated chrysin, a natural flavonoid extracted from honey, and propolis anti-inflammatory effects.
The study included human OA chondrocytes pretreated with chrysin (1, 5, 10 μM) for 2 h and subsequently stimulated with IL-1β, an inflammatory cytokine for 24 h.
Injection of chrysin exerted a strong inhibition activity against the degradation of aggrecan and collagen-II.
Chrysin significantly inhibited the IL-1β-induced production inflammatory cytokines such as degradation of c of NO and PGE2; expression of COX-2, iNOS.
Futhermore, chrysin also reduced the expression of matrixes such as MMP-1, MMP-3, MMP-13 and enzymes ADAMTS-4, and ADAMTS-5 associated with the progression and destruction of joint in early osteoarthritis.
In the depth analysis researchers also found that chrysin dramatically blocked IL-1β-stimulated IκB-α degradation in the activation of protein NF-κB-induced production of proinflammatory cytokines.
The results suggested that chrysin inhibits the progression of OA through several mechanisms, including enzymes and proteins involving the destruction of joint tissues.
Taken altogether, honey processed a bioactive compound chrysin may be considered a functional remedy for the prevention and treatment of OA, with no side effects, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chrysin Attenuates IL-1β-Induced Expression of Inflammatory Mediators by Suppressing NF-κB in Human Osteoarthritis Chondrocytes by Zheng W1, Tao Z1, Cai L1, Chen C1, Zhang C1, Wang Q1, Ying X1, Hu W1, Chen H2. (PubMed)
(2) Obesity & osteoarthritis by Lauren K. King,* Lyn March,** and Ananthila Anandacoomarasamy. (PMC)
#Healthyfood #Avocado inhibits Parameters Associated with #HighBloodCholesterol and Obesity, Scientists Say
Kyle J. Norton
Avocado may process certain bioactive compounds with the function of inhibiting the abnormal levels of blood cholesterol in the bloodstream, some scientists suggested.
Cholesterol produced by the liver or intake from food sources plays an important role in building the cell membrane walls and stimulating the production of steroid hormones and aided the digestive tract in absorbing the nutrients for our body needs.
However, a prolonged period of overexpression of abnormal blood cholesterol in the bloodstream can cause plaque to build up on the arterial wall, leading to heart disease and stroke.
Depending on the choice of diet, your risk of high blood cholesterol can be increased or decreased.
People who follow the Western diet with high in saturated and trans fat, red meat, processed food, and low in fruits and vegetables and whole grains may have a substantially increased risk of abnormally high blood cholesterol.
According to the article "Western Diet and Heart Risk", the author wrote, "“Western diets cause a third of heart attack deaths worldwide,” the Daily Mail reports. Western-style diets high in meat, fat, dairy, and salt put people at higher risk of heart attack. According to the newspaper, a study has found that poor diet is responsible for 30% of the risk of heart disease".
These results suggested that regardless of the levels of blood cholesterol today, by changing to a healthy diet and lifestyle with moderate exercise, you are at a lower risk of high blood cholesterol in the future (weeks or months, depending on the levels of blood cholesterol today).
The healthy ratio of blood cholesterol is 4 (low-density lipoprotein) to 1 (high-density lipoprotein).
If your ratio is lower than 4, you are considered to have a healthy blood-cholesterol ratio.
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world.
It is a green-skinned, pear-shaped fruit that ripens after harvesting and is native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
Researchers in the examination of traditionally consumed fruit avocado, use for the treatment of fat lowering capacity launched an experiment to evaluate the effect of hydro-alcoholic fruit extract of P. Americana (HAEPA) on the level of blood lipids, glutathione, lipid peroxidation products, adiponectin, and peroxisome proliferator-activated receptor (PPAR)-γ expressions.
The study includes Male Sprague Dawley rats divided into four groups: groups 1 and 2 were fed normal rat chow (5% fat) and groups 3 and 4 were fed HFD (23% fat) for a period of 14 weeks. In addition, groups 2 and 4 rats were administered orally with 100 mg/kg body weight of HAEPA from the third week.
The rat group treated with additional HAEPA showed a significantly decreased body mass index (BMI), total fat pad mass, and adiposity index, compared to HFD-fed rats.
The LDL and lipid peroxidation levels of the HFD+HAEPA group were significantly lower compared to the HFD group.
Furthermore, Levels of reduced glutathione, an antioxidant enzyme, adiponectin, a protein hormone involved in regulating glucose levels and fatty acid breakdown. mRNA expression of adiponectin, PPAR-γ and protein expression of PPAR-γ in the mediating expression of fat-specific genes and in activating the program of adipocyte differentiation was found to be increased in the HFD+HAEPA group than in the HFD group.
The findings suggested that HAEPA exhibits antihyperlipidemic activity by increasing the mRNA expression of adiponectin and PPAR-γ, which reduces the risk of hyperlipidemia and obesity.
In a study to examine the avocado oil administration effect on biochemical markers of cardiovascular risk profile in rats with metabolic changes induced by sucrose ingestion 25 rats were divided into five groups: a control group (CG; basic diet), a sick group (MC; basic diet plus 30% sucrose solution), and three other groups (MCao, MCac, and MCas; basic diet plus 30% sucrose solution plus olive oil and avocado oil extracted by centrifugation or using solvent, resp.), researchers found that
* Avocado oil reduces TG, VLDL, and LDL levels, in the LDL case significantly so, without affecting HDL levels.
* Avocado oil exerted a potential effect similar to olive oil in myocardial injury biochemical indicators.
* Avocado oil decreased hs-CRP levels, indicating that inflammatory processes were partially reversed.
Dr. Carvajal-Zarrabal O, the lead author wrote in the final paper, "Avocado oil supplementation has a positive health outcome because it reduces inflammatory events and produces positive changes in the biochemical indicators ".
Taken altogether, avocado may be considered functional food for the prevention and treatment of high blood cholesterol without inducing side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of Persea americana (avocado) fruit extract on the level of expression of adiponectin and PPAR-γ in rats subjected to experimental hyperlipidemia and obesity by Monika P, Geetha A.(PubMed)
(2) Avocado oil supplementation modifies cardiovascular risk profile markers in a rat model of sucrose-induced metabolic changes by Carvajal-Zarrabal O1, Nolasco-Hipolito C2, Aguilar-Uscanga MG3, Melo-Santiesteban G4, Hayward-Jones PM1, Barradas-Dermitz DM5. (PubMed)
Avocado may process certain bioactive compounds with the function of inhibiting the abnormal levels of blood cholesterol in the bloodstream, some scientists suggested.
Cholesterol produced by the liver or intake from food sources plays an important role in building the cell membrane walls and stimulating the production of steroid hormones and aided the digestive tract in absorbing the nutrients for our body needs.
However, a prolonged period of overexpression of abnormal blood cholesterol in the bloodstream can cause plaque to build up on the arterial wall, leading to heart disease and stroke.
Depending on the choice of diet, your risk of high blood cholesterol can be increased or decreased.
People who follow the Western diet with high in saturated and trans fat, red meat, processed food, and low in fruits and vegetables and whole grains may have a substantially increased risk of abnormally high blood cholesterol.
According to the article "Western Diet and Heart Risk", the author wrote, "“Western diets cause a third of heart attack deaths worldwide,” the Daily Mail reports. Western-style diets high in meat, fat, dairy, and salt put people at higher risk of heart attack. According to the newspaper, a study has found that poor diet is responsible for 30% of the risk of heart disease".
These results suggested that regardless of the levels of blood cholesterol today, by changing to a healthy diet and lifestyle with moderate exercise, you are at a lower risk of high blood cholesterol in the future (weeks or months, depending on the levels of blood cholesterol today).
The healthy ratio of blood cholesterol is 4 (low-density lipoprotein) to 1 (high-density lipoprotein).
If your ratio is lower than 4, you are considered to have a healthy blood-cholesterol ratio.
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world.
It is a green-skinned, pear-shaped fruit that ripens after harvesting and is native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
Researchers in the examination of traditionally consumed fruit avocado, use for the treatment of fat lowering capacity launched an experiment to evaluate the effect of hydro-alcoholic fruit extract of P. Americana (HAEPA) on the level of blood lipids, glutathione, lipid peroxidation products, adiponectin, and peroxisome proliferator-activated receptor (PPAR)-γ expressions.
The study includes Male Sprague Dawley rats divided into four groups: groups 1 and 2 were fed normal rat chow (5% fat) and groups 3 and 4 were fed HFD (23% fat) for a period of 14 weeks. In addition, groups 2 and 4 rats were administered orally with 100 mg/kg body weight of HAEPA from the third week.
The rat group treated with additional HAEPA showed a significantly decreased body mass index (BMI), total fat pad mass, and adiposity index, compared to HFD-fed rats.
The LDL and lipid peroxidation levels of the HFD+HAEPA group were significantly lower compared to the HFD group.
Furthermore, Levels of reduced glutathione, an antioxidant enzyme, adiponectin, a protein hormone involved in regulating glucose levels and fatty acid breakdown. mRNA expression of adiponectin, PPAR-γ and protein expression of PPAR-γ in the mediating expression of fat-specific genes and in activating the program of adipocyte differentiation was found to be increased in the HFD+HAEPA group than in the HFD group.
The findings suggested that HAEPA exhibits antihyperlipidemic activity by increasing the mRNA expression of adiponectin and PPAR-γ, which reduces the risk of hyperlipidemia and obesity.
In a study to examine the avocado oil administration effect on biochemical markers of cardiovascular risk profile in rats with metabolic changes induced by sucrose ingestion 25 rats were divided into five groups: a control group (CG; basic diet), a sick group (MC; basic diet plus 30% sucrose solution), and three other groups (MCao, MCac, and MCas; basic diet plus 30% sucrose solution plus olive oil and avocado oil extracted by centrifugation or using solvent, resp.), researchers found that
* Avocado oil reduces TG, VLDL, and LDL levels, in the LDL case significantly so, without affecting HDL levels.
* Avocado oil exerted a potential effect similar to olive oil in myocardial injury biochemical indicators.
* Avocado oil decreased hs-CRP levels, indicating that inflammatory processes were partially reversed.
Dr. Carvajal-Zarrabal O, the lead author wrote in the final paper, "Avocado oil supplementation has a positive health outcome because it reduces inflammatory events and produces positive changes in the biochemical indicators ".
Taken altogether, avocado may be considered functional food for the prevention and treatment of high blood cholesterol without inducing side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of Persea americana (avocado) fruit extract on the level of expression of adiponectin and PPAR-γ in rats subjected to experimental hyperlipidemia and obesity by Monika P, Geetha A.(PubMed)
(2) Avocado oil supplementation modifies cardiovascular risk profile markers in a rat model of sucrose-induced metabolic changes by Carvajal-Zarrabal O1, Nolasco-Hipolito C2, Aguilar-Uscanga MG3, Melo-Santiesteban G4, Hayward-Jones PM1, Barradas-Dermitz DM5. (PubMed)
#Phytochemicals #PhyticAcid #Alzheimer's disease (AD) by Reducing the Levels of Calcium Present, Free Radicals, and Plaque Accumulation.
Kyle J. Norton
Phytic acid, a bioactive compound found mostly in seeds and beans may have a strong and profound effect in protecting the aging brain against the onset of Alzheimer's disease (AD), some scientists suggested.
Alzheimer's disease (AD) is a neurodegenerative disease occurred mostly in the older population characterized by progressive brain cell death that happens over time.
Alzheimer's disease worsens over time and it is fatal.
As the disease progresses, the brain tissue of the patient with AD has fewer and fewer nerve cells and connections.
In the elderly, age-related changes in the brain include atrophy (shrinking) of certain parts of the brain, inflammation associated with overexpression of free radicals in the induction of neuro cytotoxicity that affects the energy production within cells and long-term accumulated of plaques in the neurons caused by unhealthy diet are many prevalent risk factors that elevate the early onset and progression of the disease.
Dr. Pini L and colleagues in the study "Brain atrophy in Alzheimer's Disease and Aging" said, "Disease progression has also been associated with changes in white matter tracts. Recent studies have investigated two areas often overlooked in AD, such as the striatum and basal forebrain, reporting significant atrophy".
The results suggested the loss of white matter tracts in the striatum and basal forebrain may be the culprit that brain shrinking in the aging population.
In the free radicals analysis, researchers suggested that free radicals overexpression causes the reduced levels of antioxidant enzymes produced by the elderly initiates the onset of oxidative stress that may attack and damage lipids, proteins, and DNA, leading to irreversible brain cells damage and development of AD.
Dr. Tuppo EE, the lead author in the study of oxidative stress and AD, said, "The brain is especially sensitive to oxidative damage because of its high content of readily oxidized fatty acids, high use of oxygen, and low levels of antioxidants" and "Evidence for oxidative damage has been obtained from postmortem brain tissue as well as from living patients with Alzheimer's disease. Antioxidants such as vitamin E show promise that they may help in treating the disease.
Phytic acid (Inositol hexaphosphate) are phytochemical of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.
Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be the next potential source of new medications for the treatment of diseases with little or no side effects.
In the finding of a novel protective treatment for AD pathology, researchers at the Oregon Health & Science University, Portland conducted an investigation to evaluate the phytic acid(inositol hexakisphosphate), a phytochemical found in food grains and a key signaling molecule in mammalian cells.
The experiment is to examine the protective and beneficial effects of phytic acid against amyloid-β (Aβ) pathology in MC65 cells and the Tg2576 mouse model.
In MC65 cells, after 48-72-hour, of treatment with phytic acid researchers showed that phytic acid provided complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by reducing the levels of calcium present, free radicals, and plaque accumulation.
Furthermore, injection of phytic acid significantly increased brain levels of cytochrome oxidase which is found in low levels in AD patients and decreased lipid peroxidation.
The phytic acid was well tolerated with little side effects.
Additionally, in finding a composition and method for the treatment of Alzheimer's disease, researchers showed that phytic acid, a phytate salt, an isomer or hydrolysate of phytic acid or a phytate salt, or a mixture of any combination administered to a person in an amount from about 0.5 grams to about 18.75 grams per day, demonstrated a potential effect in reducing amyloid plaque development.
In the experiment, researchers also discovered that very low doses of phytic acid are effective in the treatment and prevention of aggregation of beta-amyloid proteins as are commonly seen in the brains of Alzheimer's patients.
Taken altogether, the phytic acid found abundant in nuts and seeds may be considered a functional supplement for the prevention of AD and an adjunct therapy combined with conventional medicine for the treatment of neurodegenerative diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Phytic acid as a potential treatment for Alzheimer's pathology: evidence from animal and in vitro models by Anekonda TS, Wadsworth TL, Sabin R, Frahler K, Harris C, Petriko B, Ralle M, Woltjer R, Quinn JF.(PubMed)
(2) Prophylactic and therapeutic treatment of Alzheimer's disease using phytic acid and phytate to reduce amyloid beta plaque and tau protein(Patnetdocs)
(3) Brain atrophy in Alzheimer's Disease and aging by Pini L1, Pievani M2, Bocchetta M3, Altomare D1, Bosco P2, Cavedo E4, Galluzzi S2, Marizzoni M2, Frisoni GB. (PubMed)
(4) Free radical oxidative damage and Alzheimer's disease by Tuppo EE1, Forman LJ. (PubMed)
Phytic acid, a bioactive compound found mostly in seeds and beans may have a strong and profound effect in protecting the aging brain against the onset of Alzheimer's disease (AD), some scientists suggested.
Alzheimer's disease (AD) is a neurodegenerative disease occurred mostly in the older population characterized by progressive brain cell death that happens over time.
Alzheimer's disease worsens over time and it is fatal.
As the disease progresses, the brain tissue of the patient with AD has fewer and fewer nerve cells and connections.
In the elderly, age-related changes in the brain include atrophy (shrinking) of certain parts of the brain, inflammation associated with overexpression of free radicals in the induction of neuro cytotoxicity that affects the energy production within cells and long-term accumulated of plaques in the neurons caused by unhealthy diet are many prevalent risk factors that elevate the early onset and progression of the disease.
Dr. Pini L and colleagues in the study "Brain atrophy in Alzheimer's Disease and Aging" said, "Disease progression has also been associated with changes in white matter tracts. Recent studies have investigated two areas often overlooked in AD, such as the striatum and basal forebrain, reporting significant atrophy".
The results suggested the loss of white matter tracts in the striatum and basal forebrain may be the culprit that brain shrinking in the aging population.
In the free radicals analysis, researchers suggested that free radicals overexpression causes the reduced levels of antioxidant enzymes produced by the elderly initiates the onset of oxidative stress that may attack and damage lipids, proteins, and DNA, leading to irreversible brain cells damage and development of AD.
Dr. Tuppo EE, the lead author in the study of oxidative stress and AD, said, "The brain is especially sensitive to oxidative damage because of its high content of readily oxidized fatty acids, high use of oxygen, and low levels of antioxidants" and "Evidence for oxidative damage has been obtained from postmortem brain tissue as well as from living patients with Alzheimer's disease. Antioxidants such as vitamin E show promise that they may help in treating the disease.
Phytic acid (Inositol hexaphosphate) are phytochemical of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.
Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be the next potential source of new medications for the treatment of diseases with little or no side effects.
In the finding of a novel protective treatment for AD pathology, researchers at the Oregon Health & Science University, Portland conducted an investigation to evaluate the phytic acid(inositol hexakisphosphate), a phytochemical found in food grains and a key signaling molecule in mammalian cells.
The experiment is to examine the protective and beneficial effects of phytic acid against amyloid-β (Aβ) pathology in MC65 cells and the Tg2576 mouse model.
In MC65 cells, after 48-72-hour, of treatment with phytic acid researchers showed that phytic acid provided complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by reducing the levels of calcium present, free radicals, and plaque accumulation.
Furthermore, injection of phytic acid significantly increased brain levels of cytochrome oxidase which is found in low levels in AD patients and decreased lipid peroxidation.
The phytic acid was well tolerated with little side effects.
Additionally, in finding a composition and method for the treatment of Alzheimer's disease, researchers showed that phytic acid, a phytate salt, an isomer or hydrolysate of phytic acid or a phytate salt, or a mixture of any combination administered to a person in an amount from about 0.5 grams to about 18.75 grams per day, demonstrated a potential effect in reducing amyloid plaque development.
In the experiment, researchers also discovered that very low doses of phytic acid are effective in the treatment and prevention of aggregation of beta-amyloid proteins as are commonly seen in the brains of Alzheimer's patients.
Taken altogether, the phytic acid found abundant in nuts and seeds may be considered a functional supplement for the prevention of AD and an adjunct therapy combined with conventional medicine for the treatment of neurodegenerative diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Phytic acid as a potential treatment for Alzheimer's pathology: evidence from animal and in vitro models by Anekonda TS, Wadsworth TL, Sabin R, Frahler K, Harris C, Petriko B, Ralle M, Woltjer R, Quinn JF.(PubMed)
(2) Prophylactic and therapeutic treatment of Alzheimer's disease using phytic acid and phytate to reduce amyloid beta plaque and tau protein(Patnetdocs)
(3) Brain atrophy in Alzheimer's Disease and aging by Pini L1, Pievani M2, Bocchetta M3, Altomare D1, Bosco P2, Cavedo E4, Galluzzi S2, Marizzoni M2, Frisoni GB. (PubMed)
(4) Free radical oxidative damage and Alzheimer's disease by Tuppo EE1, Forman LJ. (PubMed)
#Phenolic-Enriched #Extracts Found In #Eggplant Inhibit #Hypertension and #Diabetes through Anti Oxidative Activities, Scientists Say
Kyle J. Norton
Eggplant may be considered a functional food for the prevention and treatment of type 2 diabetes, some scientists suggested.
Diabetes is a chronic medical condition caused by insufficient insulin entering the bloodstream to regulate glucose.
Insulin resistance, a hallmark for the early onset of the diseases is caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol.
People with insulin resistance, the pancreas has to work overtime to deploy greater amounts of the hormone to keep cells energized and blood glucose levels under control. However, a long-term overworked pancreas can lead to reduced function of pancreatic beta cells in making insulin. These results eventually cause damage to the pancreas impaired function that no longer produces enough insulin to overcome the cells' resistance.
Cholesterol may be necessary for the body to function properly, however, the impaired ratio of lower density and high-density lipoprotein only causes cholesterol plaque to build upon the walls of arteries but also can clog up the insulin receptor sites, leading to the spike of blood glucose.
People who follow the Western diet with high on saturated and trans fat, red meat, processed food and less in fruits and vegetables and whole grains are associated with increased risk of type 2 diabetes caused by clogging up on the insulin receptors.
Please make sure that you maintain a healthy total blood cholesterol ratio of 4 (low-density lipoprotein, LDL) to 1 (high-density lipoprotein, HDL).
In other words, insulin produced by the pancreas still binds to the receptor normally, but the signal is not sent into the cell, the cells do not take up glucose and the resulting high blood glucose levels cause organ damage over time.
In some cases, acute high blood glucose can also be caused by an allergic reaction of the cells in the immune system.
Some researchers suggested that these may be a result associated with the use of OTC or prescription nasal spray, containing steroids. People with diabetes should be aware that steroids can stimulate the liver to make more glucose.
Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
The vegetable is famous for its deep purple and the best eggplant can be found from August through October when it is in season.
In the reaffirming of the National Diabetes Education Program of NIH, Mayo Clinic, and American Diabetes Association recommendation that an eggplant-based diet as a choice for the management of type 2 diabetes, researchers launched an investigation to examine the phenolic-linked antioxidant activity and alpha-glucosidase inhibitory potential of eggplant which could reduce hyperglycemia-induced pathogenesis.
At the end of the experiment, researchers found that
* Phenolic-enriched extracts of eggplant process a moderate free radical scavenging-linked antioxidant activity and high angiotensin I-converting enzyme (ACE) inhibitory activity that plays an essential role not only prevent high blood pressure but also stimulates the release of aldosterone from the adrenal cortex to promote sodium retention by the kidneys.
* The extracts also had a high alpha-glucosidase inhibitory activity which prevents the digestion of carbohydrates
Inhibition of these enzymes provides a strong biochemical basis for management of type 2 diabetes by controlling glucose absorption and reducing associated hypertension, respectively.
Dr. the lead author wrote, "phenolic antioxidant-enriched dietary strategy also has the potential to reduce hyperglycemia-induced pathogenesis linked to cellular oxidation stress".
Additionally, in the examine the anti-diabetes effect of chlorogenic acids (CGAs) received considerable attention for their wide distribution and part of the human diet with potential biological effects, researchers launched an investigation to examine CGAs found in eggplant.
At the end of the experiment, researchers found that
* Coffee is among the highest found in plants, ranging from 4 to 14%.of chlorogenic acids (CGAs) compared to eggplant
* CGA besides processes strong antioxidant and anti-inflammatory effects, it also plays an important role on glucose and lipid metabolism regulation and in related disorders, e.g. diabetes, cardiovascular disease (CVD), obesity, cancer, and hepatic steatosis.
Dr. the lead author after taking into account ac and confounders said, " The wide range of potential health benefits of CGA, including its anti-diabetic, anti-carcinogenic, anti-inflammatory and anti-obesity impacts, may provide a non-pharmacological and non-invasive approach for treatment or prevention of some chronic diseases".
Taken altogether, eggplant may be considered a functional food for the prevention and a secondary therapy combined with conventional medicine for the treatment of diabetes without inducing adverse effects.
However, further data collection large example size and multi-center studies performed with human consumption of the eggplant or its bioactive compounds during the course of the disease will be necessary to complete the picture of eggplant anti-diabetes possibilities.
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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension by Kwon YI1, Apostolidis E, Shetty K.(PubMed)
(2) An outlook on chlorogenic acids-occurrence, chemistry, technology, and biological activities by Upadhyay R1, Mohan Rao LJ. (PubMed)
(3) The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature by Tajik N1, Tajik M2, Mack I1, Enck P. (PubMed)
Eggplant may be considered a functional food for the prevention and treatment of type 2 diabetes, some scientists suggested.
Diabetes is a chronic medical condition caused by insufficient insulin entering the bloodstream to regulate glucose.
Insulin resistance, a hallmark for the early onset of the diseases is caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol.
People with insulin resistance, the pancreas has to work overtime to deploy greater amounts of the hormone to keep cells energized and blood glucose levels under control. However, a long-term overworked pancreas can lead to reduced function of pancreatic beta cells in making insulin. These results eventually cause damage to the pancreas impaired function that no longer produces enough insulin to overcome the cells' resistance.
Cholesterol may be necessary for the body to function properly, however, the impaired ratio of lower density and high-density lipoprotein only causes cholesterol plaque to build upon the walls of arteries but also can clog up the insulin receptor sites, leading to the spike of blood glucose.
People who follow the Western diet with high on saturated and trans fat, red meat, processed food and less in fruits and vegetables and whole grains are associated with increased risk of type 2 diabetes caused by clogging up on the insulin receptors.
Please make sure that you maintain a healthy total blood cholesterol ratio of 4 (low-density lipoprotein, LDL) to 1 (high-density lipoprotein, HDL).
In other words, insulin produced by the pancreas still binds to the receptor normally, but the signal is not sent into the cell, the cells do not take up glucose and the resulting high blood glucose levels cause organ damage over time.
In some cases, acute high blood glucose can also be caused by an allergic reaction of the cells in the immune system.
Some researchers suggested that these may be a result associated with the use of OTC or prescription nasal spray, containing steroids. People with diabetes should be aware that steroids can stimulate the liver to make more glucose.
Eggplant is a species of S. melongena, belonging to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
The vegetable is famous for its deep purple and the best eggplant can be found from August through October when it is in season.
In the reaffirming of the National Diabetes Education Program of NIH, Mayo Clinic, and American Diabetes Association recommendation that an eggplant-based diet as a choice for the management of type 2 diabetes, researchers launched an investigation to examine the phenolic-linked antioxidant activity and alpha-glucosidase inhibitory potential of eggplant which could reduce hyperglycemia-induced pathogenesis.
At the end of the experiment, researchers found that
* Phenolic-enriched extracts of eggplant process a moderate free radical scavenging-linked antioxidant activity and high angiotensin I-converting enzyme (ACE) inhibitory activity that plays an essential role not only prevent high blood pressure but also stimulates the release of aldosterone from the adrenal cortex to promote sodium retention by the kidneys.
* The extracts also had a high alpha-glucosidase inhibitory activity which prevents the digestion of carbohydrates
Inhibition of these enzymes provides a strong biochemical basis for management of type 2 diabetes by controlling glucose absorption and reducing associated hypertension, respectively.
Dr. the lead author wrote, "phenolic antioxidant-enriched dietary strategy also has the potential to reduce hyperglycemia-induced pathogenesis linked to cellular oxidation stress".
Additionally, in the examine the anti-diabetes effect of chlorogenic acids (CGAs) received considerable attention for their wide distribution and part of the human diet with potential biological effects, researchers launched an investigation to examine CGAs found in eggplant.
At the end of the experiment, researchers found that
* Coffee is among the highest found in plants, ranging from 4 to 14%.of chlorogenic acids (CGAs) compared to eggplant
* CGA besides processes strong antioxidant and anti-inflammatory effects, it also plays an important role on glucose and lipid metabolism regulation and in related disorders, e.g. diabetes, cardiovascular disease (CVD), obesity, cancer, and hepatic steatosis.
Dr. the lead author after taking into account ac and confounders said, " The wide range of potential health benefits of CGA, including its anti-diabetic, anti-carcinogenic, anti-inflammatory and anti-obesity impacts, may provide a non-pharmacological and non-invasive approach for treatment or prevention of some chronic diseases".
Taken altogether, eggplant may be considered a functional food for the prevention and a secondary therapy combined with conventional medicine for the treatment of diabetes without inducing adverse effects.
However, further data collection large example size and multi-center studies performed with human consumption of the eggplant or its bioactive compounds during the course of the disease will be necessary to complete the picture of eggplant anti-diabetes possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) In vitro studies of eggplant (Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension by Kwon YI1, Apostolidis E, Shetty K.(PubMed)
(2) An outlook on chlorogenic acids-occurrence, chemistry, technology, and biological activities by Upadhyay R1, Mohan Rao LJ. (PubMed)
(3) The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature by Tajik N1, Tajik M2, Mack I1, Enck P. (PubMed)
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