#Herbal #Fennel Exerts Cytotoxity Against #CervicalCancer without Harming Healthy Cells through Its #Antioxidant Property, Researchers Say

Kyle J. Norton

Fennel may be the next generative functional food with the potency in blocking the overexpression of free radicals in the induction of chronic illness, some scientists suggested.

Free radicals are highly reactive molecules with unpaired electrons that cause oxidation by stealing an electron from other molecules to give rise to a chain activity. Once free radical starts its domino effect, it can not be stopped until two free radical species react with each other to form a stable, non-radical adduct or are inhibited by the presence of antioxidants.

Antioxidants, on the other hand, are stable molecules that inhibit oxidation caused by free radicals.

The relationship between free radicals and antioxidant are summarized by Dr. V. Lobo, the lead author in the study "Free radicals, antioxidants, and functional foods: Impact on human health ", "A balance between free radicals and antioxidants is necessary for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues. Free radicals thus adversely alter lipids, proteins, and DNA and trigger a number of human diseases. Hence the application of an external source of antioxidants can assist in coping with this oxidative stress".

These explanations suggested that intake of antioxidants from the food sources in the stimulation of antioxidant enzymes in the body is beneficial in maintaining good health, However, the doctors continued, "Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health. Thus, the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years".

Overexpression of free radicals or imbalance of the ratio of free radicals and antioxidants in the body can initiate oxidative stress. A prolonged period of oxidative stress in the human body plays a major part in the development of chronic and degenerative illnesses such as cancer, autoimmune disorders, aging, cataract, rheumatoid arthritis, and cardiovascular and neurodegenerative diseases.

Fennel (Foeniculum vulgare) is a plant species of the genus Foeniculum, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.

The functional herb has been used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepression agent to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, regulate the menstrual cycle, relieve PMS,...

Fennel is an excellent source of natural antioxidants and contributes to the daily antioxidant diet. The functional food is found to process a free radical scavenging activity, particularly in the application of its phenolic and flavonoids.

In the examine the effects of fennel essential oil in the presence of overexpression of free radicals, researchers found, injection of the oil exerts an intense antioxidant activity in comparison with butyrated hydroxyanisole and butylated hydroxytoluene., however, injection of ethanol and water extracts of fennel showed less effective compared to the essential oil.

Furthermore, in the evaluation of the essential oils of the fruits of three organically grown cultivars of Egyptian fennel (Foeniculum vulgare var. azoricum, Foeniculum vulgare var. dulce, and Foeniculum vulgare var. vulgare) in antibacterial and antioxidant effects, researchers showed that all three cultivars contain a great source of trans-Anethole, estragole, fenchone, and limonene.


All phytochemicals demonstrated significant activity in free radical scavenging, in inhibited lipid peroxidation, and metal chelation.

Additional differentiation suggested that essential oils from the azoricum and dulce cultivars were more effective antioxidants than that from the vulgare cultivar and essential oils from 3 species display similar antimicrobial activities against two species of fungi, two species of Gram-negative and two species of Gram-positive bacteria.

More importantly, in the examine the effect of essential oil of fennel (Foeniculum vulgare) lipophilic secondary metabolites, researchers at the Avicenna Tajik State Medical University, discovered that
* The oil exhibited moderate antioxidant activities.

* The antioxidants in the essential oil are found to protect the healthy cells and stimulate the expression of free radical in exerting cytotoxic activity against HeLa (human cervical cancer), Caco-2 (human colorectal adenocarcinoma), MCF-7 (human breast adenocarcinoma), CCRF-CEM (human T lymphoblast leukemia) and CEM/ADR5000 (adriamycin resistant leukemia) cancer cell lines;

* The most effective of the IC50 values are between 30-210 mg L-1.

These results suggested that essential oil from fennel processing is a great source of antioxidants to balance the ratio of free radicals in the body, thus preventing the initiation of oxidative stress.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Chemical composition, antimicrobial and antioxidant activities of essential oils from organically cultivated fennel cultivars by Shahat AA1, Ibrahim AY, Hendawy SF, Omer EA, Hammouda FM, Abdel-Rahman FH, Saleh MA(PubMed)
(3) Cytotoxicity of the Essential Oil of Fennel (Foeniculum vulgare) from Tajikistan by Sharopov F1,2, Valiev A3, Satyal P4, Gulmurodov I5, Yusufi S6, Setzer WN7, Wink M8(PubMed)
(4) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)

#Herbal #CatnipEssentialOil Shows a Significant Effect on Microbial Infection, According to Studies

Kyle J. Norton

Herbal catnip was found to process certain chemical compounds which stimulate the immune function against microbial organisms in the acute and chronic phases of infection, some scientists suggested.

In humans, anti-microbial activity is a natural reaction in which the macrophages of the immune system in response to the early phase of infection stimulate the production of inflammatory cytokines which have a unique function in killing off foreign pathogens before they can cause harm to the body.

In plants, antimicrobial substances produced by the plant are served as plant defense mechanisms against predation by microorganisms.

However, overproduction of proinflammatory cytokines in many cases can mistakenly cause damage to healthy cells and tissue in the site of infection, leading to abnormal skin and scar formation.


There are 2 types of inflammatory cytokines: the proinflammatory (such as IL-1β, IL-6. and TNF-α) and anti-inflammatory (such as IL-4, IL-6, IL-10, and IL-11) cytokines. Some cytokines process a duo inflammatory (such as IL-6) functions, under normal conditions, they act as anti-inflammatory agents to protect against inflammation. Once they sense the danger to the body, they can quickly switch to pro-inflammatory cytokines.


Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia.

The functional herb has been used in herbal medicine as an insect repellant and to treat digestive disorders, children's restlessness and nervousness, fevers, colds and flu, skin irritation, stimulate sweating, promote menstruation, etc.

Ingredients
Besides, having the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc.

In the finding of the natural alternatives in replacement of traditional antibiotics with no side effects, researchers at the Shiraz University of Medical Sciences launched an evaluation to examine the antimicrobial activity of the essential oil derived from herbal Catnip.


Chemical 4a-α, 7-α, 7a-β-nepetalactone (55-58%), and 4a-α, 7-β, 7a-α-nepetalactone (30-31.2%) isolated from the essential oil were effective in exerting their antimicrobial activity against all tested bacteria at concentrations of 0.125-4 μL/mL and the growth of Candida species at a concentration less than 1 μL/mL.

The essential oil chemical constituent nepetalactone is also found to process anti-antibacterial, antifungal, insecticidal, and antioxidant activities.

Terpenenes or terpenoids found abundant in Catnip is active against bacteria, fungi, viruses, and protozoa. According to the 1977 report, 60% of essential oil derivatives derived from terpenoids demonstrated inhibition of fungi and while only 30% inhibited bacteria.

Furthermore, the extract of catnip also displayed inhibitory activity on the growth, enzyme production, and adhesion of some bacteria.

Moreover, the essential oil extract from Catnip also exhibited anti-bactericidal activity against Gram-positive bacteria at concentrations ranging from 0.5 to 8 μL/mL.

All of the Gram-negative bacteria were susceptible to the Catnip oils at concentrations of 0.25–32 μL/mL

The essential oil of Catnip from different growth stages exhibited bacteriostatic and bactericidal activities against the Shigella and Salmonella species at concentrations of 0.25–2 μL/mL and 0.5–8 μL/mL, respectively.

Additionally, the essential oil inhibited the growth of the standard species of Aspergillus at a concentration of 0.25–1 μL/mL.

Compared to the antibacterial effect of some herbs, including Catnip, researchers found that Lavender oil is more effective in the exhibited antibacterial ability than Catnip essential oil, probably based on the synergistic values of important oil components.

Nevertheless, only a few published reports are available regarding the antimicrobial effects of the catnip EOs, especially against food-borne and resistant microorganisms, Dr. Zomorodian K, the lead author suggested.

Taken together, the essential oil derived from catnip may be considered an adjunct therapy for the treatment of microbial infection.

Today, mainstream medicine antibiotics have become less effective as many viral and bacteria have developed resistance to the application due to being overused.

Secondary metabolites of plants processed antimicrobial properties with no side effects have been promoted by some companies as natural alternatives to antibiotics. The general public must be aware that many of these compounds are currently available as unregulated botanical preparations.

Please make sure that you follow the guideline of the product closely, as acute liver toxicity has been reported in some cases.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Chemical Composition and Antimicrobial Activities of Essential Oils from Nepeta cataria L. against Common Causes of Food-Borne Infections by Kamiar Zomorodian, Mohammad Jamal Saharkhiz, Samaneh Shariati, Keyvan Pakshir, Mohammad Javad Rahimi, and Reza Khashei(PubMed)
(2) Effects of Nepeta menthoides aqueous extract on retention and retrieval of memory in mice by Sarahroodi S, Jafari-Najafi R, Nasri S, Rohampour K, Maleki-Jamshid A, Esmaeili S.(PubMed)

#Herbal #Catsclaw Exerts Antiproliferative Activity Against #BreastCancer Cells by Blocking Cell Division through Cell Cycle Arrest in Vitro, According to Studies

Kyle J. Norton


Scientists may have found a functional herb that has the potential to treat breast cancer without including any side effects, some studies suggested.

Most breast cancer irregular cell growth starts on the surface of the inner linings of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma).

At the later stage, after colonizing most parts of breast tissue, malignant cells can travel a distance far way from the original site to infect other healthy tissue or organs through the fluid and blood circulation.


In Canada, the risk of getting invasive breast cancer during a lifetime before the age of 90 of a woman is 1/11.

The exact causes of breast cancer are unknown. However certain risk factors are found to associate to the early onset of the disease, including an increase in age, gender, early menstrual periods and late menopause, unhealthy diet and lifestyle, dense breast tissue,.. and genetic preposition.

However, women with the genetic mutation BRCA1 and BRCA found in 5-10% of all breast cancer cases in the United States. are at substantial risk to have breast cancer development.

According to the information provided by the University of Cambridge in the United Kingdom, out of the 3,886 women with mutation of gene BRCA1 and BRCA2 eligible for breast cancer risk analysis, 426 developed breast cancer during the study period, representing a odds relative risk ratio of 1.11.

The peak incidence of breast cancer was seen in women 41–50 years old for BRCA1 mutation carriers and those 51–60 years old for BRCA2 mutation carriers.

The cumulative risk estimates for developing breast cancer by age 80 were 72% for BRCA1 carriers and 69% for BRCA2 carriers.

Therefore, women who carry the mutation of gene BRCA1 and BRCA2 may want to take preventive measures such as intensive early surveillance, use of chemoprevention, and prophylactic surgery to the risk of breast cancer onset.

Cat's claw found in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.

The herb has been used in traditional medicine for over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer, and diseases of the urinary tract, etc.

The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, Harman, hirsuteine, hirsutine, iso-pteropodine, etc.

In the reaffirming of the use of herbal Cat's claw as anti-cancer activity in South-American folk medicine, researchers at the Istituto Nazionale per lo Studio e la Cura dei Tumori launched an investigation to examine the extract anti-breast cancer effect on a human breast cancer cell line (MCF7).

Application of the exacts display a potency in the inhibition of MCF7 through the cytostatic effects against cell growth and division in the breast cancer cell line

Furthermore, the Cat's claw extracts a strong antimutagenic activity by restoring the cell DNA to a healthy level.

Moreover, the extracts and fractions also exert a direct antiproliferative activity at the doses of 10 mg/ml and 20 mg/ml on an IC50 by blocking cell division through cell cycle arrest.


Moreover, the concentration of 100 mg/ml of two active fractions isolated from Cat's Claw inhibited 90% of breast cancer cells in MCF7.

These results suggested Cat's extract and its active fractions may be considered secondary therapy for the treatment of breast cancer.

However, due to the limitation of the above studies, additional data collection large example size and multi-center studies performed with human consumption of whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of Cat's claw anti-breast cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Reference
(1) The topical plant database (Raintree)
(2) The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line bt Riva L, Coradini D, Di Fronzo G, De Feo V, De Tommasi N, De Simone F, Pizza C.(PubMed)

#Edmodin Found In #Herbal #CascaraSagrada, the Potential Anti #Cancer BioactiveCompound in Vitros, Researchers Find

Kyle J. Norton


Cascara sagrada bioactive compound Emodin may process a potential effect as an adjunct therapy for treatment of various types of cancers, some studies found.

Cancer is the class of medical and chronic diseases associated with the alternation of cell DNA that causes cells to grow disorderly and uncontrollably.

At the early stage, most cancers start on the surface of the inner lining of the tissue or organs. However, after colonizing most parts of the organ, the cancerous cells can travel a distance away from the original site to infect other healthy tissue and organs.

The exact causes of cancers are unknown, Certain risk factors epidemiologically are found to associate with the early onset of the disease, including aging, tobacco, sun exposure, radiation exposure, chemicals, and other substances, some viruses and bacteria, certain hormones, family history of cancer, alcohol, poor diet, lack of physical activity, or being overweight.

However, most people who have some of the above risk factors do not develop cancers.

The symptoms of cancers are totally depending on the location, tissue, and organ, Cancers do not induce symptoms until they grow large enough to push on nearby organs, blood vessels, and nerves, that connect to the central nervous system.
The most common and general symptoms include fever, extreme tiredness (fatigue), or weight loss.

Cancers required a lot of energy for growth and survival. To steal more energy, some cancers secrete chemical substances that allow the growth of new blood vessels to supply them with more nutrients and fluid.

Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America,.

The herbal plant's bark has been used in traditional medicine for gastrointestinal support.

Besides the main compound of anthraquinones, other compounds of Cascara sagrada include anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.

In the study of the anti-cancer activity of Emodin, a major compound isolated from Cascara sagrada, researchers at the Université François-Rabelais de Tours launched an investigation to examine the effect on the adenosine 5'-triphosphate (ATP)-gated Ca(2+)-permeable channel P2X7 receptor (P2X7R) which is strongly upregulated in many tumors and cancer cells, and has an important role in cancer cell invasion associated with metastases.

Injection of emodin at doses ≤10 µM in cell culture had no or very mild effect on the cell viability on P2X7R. However, at the concentration of 1 and 10 µM emodin inhibited the ATP elicited increases in intracellular Ca(2+) concentration by 35 and 60%.

Furthermore, ATP-induced increase in gelatinolytic activity, in cancer cell invasiveness in vitro and in cell morphology changes were prevented by 1 µM emodin.

Moreover, the in vivo invasiveness of the P2X7R-positive MDA-MB-435s breast cancer cells was also suppressed by 40 and 50% by 1 and 10 µM emodin.

Additionally, in the study to explore a new horizon in the anticancer property of agents with relevance to mitotic arrest, including antimitotic activity of a series of naturally occurring anthracene-derived anthraquinones including anthrone, alizarin (1,2-dihydroxyanthraquinone), quinizarin (1,4-dihydroxyanthraquinone), Rhein (4,5-dihydroxyanthraquinone-2-carboxylic acid), emodin (1,6,8-trihydroxy-3-methylanthraquinone), and aloe emodin (1,8-dihydroxy-3-hydroxymethyl anthraquinone), researchers found that all tested compound inhibited the mitosis after 3, 6, and 24 h, respectively in a dose-dependent manner.

Emodin at 500 ppm was proved to be the most active compound to arrest the mitosis after 24 h second to the alizarin.

Taken altogether, herbal Cascara Sagrada processes high amounts of Emodin may be considered a functional food for prevention and adjunct therapy for treatment of cancers, pending to further data collection large example size, and multi-center studies performed on humans.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
1. Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors.
Jelassi B, Anchelin M, Chamouton J, Cayuela ML, Clarysse L, Li J, Goré J, Jiang LH, Roger S.(PubMed)
2. Evaluation of natural anthracene-derived compounds as antimitotic agents by Badria FA, Ibrahim AS. (PubMed)

#Anthocyanin-rich Bilberry Inhibits the Risk of #UlcerativeColitis Through Its Antioxidant Activity, Researchers Reveal

Kyle J. Norton

Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) caused by the inflammation associated with colon and rectum.

Symptoms of UC is totally depending on the severity of the disease, including diarrhea, often with blood or pus, persistent abdominal pain, rectal pain, and bleeding, particularly the inability to defecate despite the urgency.

Some patients with UC may also have symptoms of weight loss, fatigue, and fever.

According to the statistics in the US, out of 1.6 million Americans with inflammatory bowel disease, 907,000 of them have ulcerative colitis.

Depending on the location, the most common types of UC can be classified into

* Acute severe ulcerative colitis is a medical emergency that requires immediate hospitalization. The condition affects the entire colon with severe acute symptoms of pain, profuse diarrhea, bleeding, and fever.

* Ulcerative proctitis is an Inflammation of the anus (rectum), inducing symptoms of rectal bleeding.

* Proctosigmoiditis is an Inflammation involving the rectum and sigmoid colon (lower end of the colon).

The exact causes of UC are not cleared. Some researchers suggested there are a complex interaction of genetics, immune response, and environmental triggers that cause the onset of the disease.

The most common risk factors of UC include genetic preposition, autoimmune diseases, smoking, use of certain medications such as antibiotics, and smoking.

Some researchers suggested that UC may be correlated with the increase in the age as the disease affected 10–30% of the population older than 60 years.

Dr. Wei-Chen, the lead scientist wrote, " Elderly patients with UC will be seen more frequently with the aging of the population and increasing incidence of UC. The management of UC in the elderly population is more complex due to comorbidities and polypharmacy".

Bilberry is a species of low-growing shrub in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

On finding a natural compound or whole food for the treatment of ulcerative colitis (UC), as a significant fraction of patients with ulcerative colitis (UC) is not sufficiently controlled with conventional therapy or suffer from therapy-related side effects, researchers examined the anthocyanin-rich bilberry extract (ARBE) on the colon specimens obtained during an open pilot study using ARBE for the treatment of mild-to-moderate UC.

Pretreatment of ARBE inhibited the expression of IFN-γ-receptor 2 which plays a critical role in the regulation of mediated immune responses and organ-specific autoimmunity in human THP-1 monocytic cells.

After 6 weeks of treatment, ARBE treatment revealed reduced production of the pro-inflammatory cytokines including IFN-γ and TNF-α.

Furthermore, ARBE treatment featured enhanced levels of Th17-cell-specific cytokine IL-22 and immunoregulatory cytokine IL-10 by restoring the balance between Th17 and Treg cells and preventing the risk of chronic inflammation and pathogenesis of many autoimmune diseases.


Dr. Roth S, the lead scientist after taking other factors into account wrote, "a molecular mechanism underlying the anti-inflammatory effects of ARBE treatment in UC patients by modulating T-cell cytokine signaling and inhibiting IFN-γ signal transduction".

In order to reveal more information about the bilberry (Vaccinium myrtillus) property on UC, researchers analyzed the antioxidative and anti-inflammatory effects with an aim to explore the therapeutic potential of bilberries in active UC.

In the open pilot trial with a total follow-up of 9 weeks, the effect of a daily standardized anthocyanin-rich bilberry preparation included 13 patients with mild to moderate UC.

At the end of the 6-week treatment interval, 63.4% of patients achieved remission, the primary endpoint, while 90.9% of patients showed a response.
In all patients, a decrease in total Mayo score was detected (mean: 6.5 and 3.6 at screening and week 7, respectively; p<0.001).

Fecal calprotectin levels significantly decreased during the treatment phase (baseline: mean 778 μg/g, range 192-1790 μg/g; end of treatment: mean 305 μg/g, range <30-1586 μg/g; p=0.049), including 4 patients achieving undetectable levels at end of treatment.

No serious adverse events were observed.

The finding strongly supports the regular use of standardized anthocyanin-rich bilberry preparation in UC in humans.

Dr. Biedermann L, said at the end of the experience, "These results clearly indicate a therapeutic potential of bilberries in UC. Further studies on mechanisms and randomized clinical trials are warranted".

Taken altogether, bilberry-processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the prevention and treatment of UC, pending the validation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis by Roth S1, Spalinger MR1, Gottier C1, Biedermann L1, Zeitz J1, Lang S1, Weber A2, Rogler G1,3, Scharl M. (PubMed)
(2) Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis - an open pilot study by Biedermann L1, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, Vavricka SR, Fried M, Weber A, Humpf HU, Peschke S, Jetter A, Krammer G, Rogler G. (PubMed)
(3) Ulcerative Colitis in Elderly People: An Emerging Issue by Wei-ChenLin, Ming-JenChen, Cheng-HsinChua, Tsang-EnWang, Horng-YuanWang, Chen-WangChang. (Science Direct)

#Phytochemicals #PhyticAcid Inhibits #ColorectalCancer by Programming Cell Death and Anti-#Cancer Cell Proliferation, Researchers Suggest

Kyle J. Norton

Phytic acid, an organic compound found much in healthy food sources may have a potential effect in reducing risk and treatment of colorectal cancer, some studies suggested.
Foods containing high levels of phytic acid including nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds,...

Colorectal cancer also known as bowel cancer, is a medical and chronic condition characterized by the abnormal proliferation of cells in the colon, rectum, or vermiform appendix due to the alternation of DNA with unidentified origin.

Colorectal cancer (CRC) is a relatively very common cancer in the Western world. The cancer is considered a slowly growing and progressing cancer in a predictable way.

Bowl is divided into 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food, and the 2nd part, the large bowel which consists of the colon and rectum, is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Why colorectal cancer is more susceptible to the West than other parts of the world. Some researchers suggested it may be a result of the Western diet. People who a diet with high saturated and trans fats, red meat, processed foods, fewer fruits and vegetables, and whole grains are associated with a substantially higher risk of colorectal cancer, compared to the traditional diet.

Dr. Alan Moss, the lead author in the cancer program at The University of Melbourne, a diet that contains high levels of red meat is associated with the risk of CRC.

The risk of colorectal is increased proportionally to the increased intake of red meat. In other words, the redder consumed the higher the risk of CRC.

And, processed meats result from salting, smoking, fermenting, or curing the meat, and common examples include ham, bacon, and sausage are also on the list of elevated risk of colorectal cancer.

In the comparison of the “Western” and “prudent” dietary patterns on the incidence of CRC, researchers showed that people who follow the Western diet have a 31% increased risk of the disease onset, compared to a 14% reduced risk of CRC in people who follow the prudent diet with high fruits and vegetables, fewer red meat and processed foods.

These results suggested, regardless to present the colorectal cancer risk, a change of diet pattern today, your risk the cancer is continuously lower, compared to before the change.

Dr, Shafie NH, the lead scientist in the researchers at the cancer program team at the Universiti Putra Malaysia in the examine whether phytic acid, a natural dietary ingredient and an essential component of nutritional diets affect colorectal cancer risk showed that

* Phytic acid exerted a strongly inhibitory colorectal cancer activity by increasing the function of proteins (up-regulation of Bax)associated with program cell death and (down-regulation of Bcl-xl) anti-cancer cell proliferation.
* Furthermore, when exposed to IP6 (phytic acid), the phytochemical up-regulates of caspase-3 and -8 expressions and activation of both caspases may also contribute to the apoptotic cell death of human colorectal adenocarcinoma HT-29 cells.

The results suggested, combined with t rice bran IP6 (phytic acid) induced apoptosis, by regulating the pro- and anti-apoptotic markers.


Moreover, in the reaffirming the significant role of phytic acid in the inhibition of colorectal cancer, Dr. Saad N, the team leader, and colleagues launched an investigation of expression changes of β-catenin and cyclooxygenase-2 (COX-2) and cell proliferation in the adenoma-carcinoma sequence after treatment with rice bran PA by immunocytochemistry.


The experiment includes a total of 72 male Sprague-Dawley rats divided into 6 equal groups with 12 rats in each group.

Cancer induction by two intraperitoneal injections of azoxymethane (AOM) was given at 15 mg/kg body weight over a 2-week period. During the post-initiation phase, two different concentrations of PA, 0.2% (w/v) and 0.5% (w/v) were administered in the diet.


Before treatment with PA, rats-induced cancer showed that β-catenin, a marker of alternation of gene transcription, COX-2 expressions associated with cancer cells proliferation, and cell proliferation of Ki-67 associated to a significant contribution in colonic cancer progression.

And, a significant positive expression and correlation were found between COX-2 expression and proliferation and the total β-catenin also demonstrated a significant positive linear relationship with total COX-2.

After the application of phytic acid, researchers found that the expression changes of β-catenin and cyclooxygenase-2 (COX-2) and cell proliferation in the adenoma-carcinoma sequence were totally inhibited by rice bran PA.

Taken together, there is no doubt that phytic acid can be considered a functional supplement in the prevention of colorectal cancer and combined with primary therapy for the treatment of the disease without inducing any side effects.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of phytic acid anti-colorectal cancer possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Pro-Apoptotic Effect of Rice Bran Inositol hexaphosphate (IP6) on HT-29 Colorectal Cancer Cells by Shafie NH, Esa NM, Ithnin H, Saad N, Pandurangan AK. (PubMed)
(2) Suppression of β-catenin and cyclooxygenase-2 expression and cell proliferation in azoxymethane-induced colonic cancer in rats by rice bran-phytic acid (PA) by Saad N, Esa NM, Ithnin H.(PubMed)
(3) The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations by Alan Moss and Kumanan Nalankilli (Gastroenterology)

#Ginger-#Turmeric Rhizomes Mixture Inhibits all Parameters Associated with the Risk of #RheumatoidArthritis, Studies Find

Kyle J. Norton

Ginger may have a potential effect on the prevention and treatment of rheumatoid arthritis, some scientists suggested.
Rheumatoid arthritis is a type of arthritis and chronic low-grade inflammatory disease associated with an immune system that mistakenly attacks the joint tissue.

According to the statistic, in the US over 1.3 million Americans were affected by rheumatoid arthritis compared to 1% of the worldwide population.

As of today, researchers do not know what trigger the immune system to make antibodies that attack the joint tissue. Why are people with the same health condition in the same family, some are susceptible to the onset of the condition while others do not.

However, they do know the increase in age, family history, gender, environment, smoking, and obesity are some prevalent risk factors of RA.

In fact, lifestyle is a preventable risk factor that has been found to elevate the risk of RA in the Western world.

Dr.Kathleen Chang, the lead scientist, in the study "Smoking and Rheumatoid Arthritis" clearly suggested that by following a healthy lifestyle, RA may be preventable.

The Doctor's team continued " Recent developments have shed light on the pathophysiology of RA in smokers, including oxidative stress, inflammation, autoantibody formation, and epigenetic changes".

And "The association of smoking and the development of RA have been demonstrated through epidemiologic studies, as well as through in vivo and animal models of RA.

These results indicated a significant change in RA risk just by quitting cigarette smoking.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

In seeking alternative therapy for patients with chronic, painful diseases, a research team at the Basic Clin Pharmacol Toxicol investigated the potential of hydroalcoholic extract of Zingiber officinale rhizomes (Z. officinale extract) in the ameliorating inflammatory process in rat rheumatoid arthritis.


Application of Z. officinale extract at doses higher than 50 mg/kg/day intraperitoneally showed a significant effect in boosting the immune activity in rats with rheumatoid arthritis.


Continued administration for 26 days of Z. officinale extract can ameliorate the clinical scores, disease incidence, joint temperature and swelling, and cartilage destruction.


The results were attributed to the extract effect in inhibiting the production of proinflammatory cytokines which play a critical role in facilitating the onset of low-grade inflammation.


The extract also reduced the immune system in the production of an antibody against the joint tissue.

Moreover, Z. officinale extract at the dose of 200 mg/kg/day was superior compared to those of 2 mg/kg/day injection of indomethacin in most of the measured parameters.

Dr. Fouda AM, in the final report, said, "These observations might make Z. officinale extract a good alternative to non-steroidal anti-inflammatory drugs for patients with rheumatoid arthritis".


In arthritis induced by a single intradermal injection of 0.1 mL of Complete Freund's adjuvant (containing heat-killed Mycobacterium tuberculosis) into the palmar surface of the left hind paw conducted by the King Faisal University, Al-Hufof, researchers examine anti-rheumatoid arthritis in rats randomly assigned to receive orally and daily (for 28 consecutive days) distilled water as a vehicle, indomethacin (1.0 mg/kg body weight), or GTaq (200 or 400 mg/kg body weight, ginger-turmeric rhizomes mixture ) from the day of arthritis induction.

Application of GTaq (especially the high dose) was more effective (4.2-38.4% higher, P < 0.05-0.001) than those of indomethacin (a non-steroidal/anti-inflammatory drug) in alleviating the loss in body weight gain, the histopathological changes in ankle joints, blood leukocytosis and thrombocytosis, iron deficiency anemia, serum hypoalbuminemia, and globulinemia.

Rats treated the Gtaq also showed a reduction of the impairment of kidney functions and the risks for cardiovascular disease.

Further analysis suggested that the protective effects of GTaq are attributed to increasing food intake and decreasing systemic inflammation and antioxidant activity in the inhibition of oxidative stress.

The finding supported the use of a ginger-turmeric rhizomes mixture for the treatment against RA severity and complications.

However, further data collection large example size and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of ginger anti-rheumatoid arthritis possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Zingiber officinale: A Potential Plant against Rheumatoid Arthritis by Al-Nahain A1, Jahan R2, Rahmatullah M. (PubMed)
(2) Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O. (PubMed)
(3) Smoking and Rheumatoid Arthritis by Kathleen Chang,1 So Min Yang,2 Seong Heon Kim,3 Kyoung Hee Han,4 Se Jin Park,5 and Jae Il Shin. (PubMed)