Kyle J. Norton
Beet or beetroot may be considered a functional food in protecting the body against the onset of diseases caused by oxidative stress, some scientists suggested.
Oxidative stress in the result of the imbalance of the ratio of free radicals and antioxidants in the body.
In other words, it is caused either by overexpression of free radicals or depletion of antioxidant enzymes produced by the host body.
A free radical is an unstable molecule with unpaired electrons in the outer ring formed when oxygen interacts with certain molecules. The highly reactive radicals once formed can start a chain reaction, like dominoes that may not stop until they are inhibited by antioxidants.
According to the free radical theory, an organism's age and sick are associated with the accumulation of free radicals that cause damage to the cells over time.
An antioxidant is a stable molecule that inhibits oxidation.
Long-term expression of oxidative stress in the body can induce aging and chronic diseases.
Dr. the lead author in the concerns of overexpression of free radicals in the risk of aging and illness launched an investigation to examine the negative effect of ROS on the risk of the depletion of antioxidant defenses.
The differentiation found that oxidative stress is involved in several age-related conditions (ie, cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer).
There is a significant association between ox-LDL and higher arterial stiffness, independent of other traditional CVD risk factors, and link atherosclerosis with oxidized LDL-cholesterol (ox-LDL) as the compound mainly responsible for its production in the elderly.
In diabetes mellitus (type 1 and 2), there is an association with an increased formation of free radicals and decreased antioxidant potential, leading to macro- and microvascular complications.
And, oxidative stress plays a pivotal role in the progression of CKD, through glomerular damage and renal ischemia and, indirectly, with inflammation, hypertension, and endothelial dysfunction.
All these results found in the differentiation suggested that by identifying different types of oxidative stress biomarkers in the facilitation of chronic illness may provide important information about the efficacy of the type of treatment, and the guiding selection of the most effective drugs/dose regimens for patients.
Beet is best known as the beetroot or garden beet and belongs to the Amaranth family. It is a perennial plant with leafy stems growing to 1–2 m tall.
The widespread oxidative stress-related chronic diseases have been a burden to health care systems such as diabetes, cardiovascular disease, and cancer concerned by many scientists.
Particularly, the medication used for the treatment of these diseases has been found to induce a number of serious side effects.
Researchers at the Poznań University of Medical Sciences in the finding the natural ingredient which processes a potential for the treatment without inducing any adverse effects launched an evaluation to analyze the effect of beetroot juice against N-nitrosodimethylamine (NDEA)-induced liver injury.
In two hepatic cell lines: non-tumor THLE-2 and hepatoma-derived HepG2 cell lines, treatment with 2, 10, and 20 μm of BET resulted in the translocation of Nrf2 from the cytosol to the nucleus., thus inhibiting the Nrf2 function that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.
These initiation caused by beet juice was an application of accompanied by the phosphorylation of serine/threonine kinase (AKT) in the mediation of carcinogenesis, JNK (c-Jun N-terminal kinase) in the regulation of that regulates the biological processes implicated in tumorigenesis, and extracellular signal-regulated kinase (ERK) in the mediation of cancer cell stages of division.
Additionally, beet juice also increased the expression of antioxidants in the gastric cell lines through significantly increased the mRNA and protein levels of GSTP, GSTT, GSTM, and NQO1, the groups of protein which play an important role in cellular protection against oxidative stress and toxic foreign chemicals, in these cells.
Interestingly, BET did not modulate any of the other parameters measured in the HepG2 cells and did not change the methylation of GSTP1 in these cells either.
The finding led us to believe that BET through the activation of Nrf2 and subsequent induction of the expression of genes controlled by this factor may exert its hepatoprotective and anticarcinogenic effects.
In other words, BET increased the levels of antioxidants by reducing the oxidative stress triggered by injury and inflammation through the protection of cell DNA against cancer initiation and the liver against the expression of chemical toxins.
Taken together beet juice may be considered a functional liquid for the inhibition of oxidative stress and adjunct therapy for the treatment of oxidative stress-related diseases, depending to the confirmation of large sample size and multi-center study in human
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) What is NRF2?
(2) Betanin, a beetroot component, induces nuclear factor erythroid-2-related factor 2-mediated expression of detoxifying/antioxidant enzymes in human liver cell lines by Krajka-Kuźniak V, Paluszczak J, Szaefer H, Baer-Dubowska W.(PubMed)
Monday, 26 June 2023
Dietary #WhiteButtonMushroom Inhibits the Risk of Serveral Types of #Cancer and #CardiovascularDisease (CVD), According to Studies
Kyle J. Norton
Scientists may have found one of the natural food used in many different cultures with the potential in reduced risk and protected against CVD.
Cardiovascular disease (CVD) is a group of conditions associated with the abnormal functioning of the heart and blood vessels.
The causes of cardiovascular diseases are associated with certain prevalent risk factors, including metabolic syndrome, diabetes, and prediabetes, smoking, family history, increase in age, and being overweight or obese.
Some researchers suggested that the coincidence of overweight and obesity and cardiovascular diseases have increased proportionally over a few decades probably correlated to the promotion of the Western diet with high fat, salts, and sugar.
Dr. Luma Akil, the lead author in the concerns of the obesity causes of elevated cardiovascular disease (CVD) mortality and morbidity among American adults conducted an. examination of the associations between the increase in body mass index (BMI) and the increased rates of CVD and high blood pressure (HBP) in the states of Mississippi, Alabama, Louisiana, Tennessee, and Colorado
The study included the data from the Behavioral Risk Factor Surveillance System that were obtained and analyzed for obesity rates, percent of myocardial infarction, stroke, and HBP from 2005–2009.
Using regression analysis, researchers found that the highest rates of obesity, CVD, and HBP were found in Mississippi, while Colorado had the lowest rates.
The result suggested that maintaining a healthy weight helps reduce the risks of developing CVD and obesity is among the leading causes of elevated cardiovascular disease (CVD) mortality and morbidity.
In other words, regular consumption of fruits and vegetables is strongly associated with a reduced risk of cardiovascular disease (CVD). Dietary fungi, such as mushrooms, can protect against chronic disease by altering inflammatory environments through inhibition of cellular processes under pro-inflammatory conditions which are associated with CVD,
Mushroom, a standard name for white button mushroom, is the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source, contains several important nutrients including Thiamine (Vitamin B1), Riboflavin (Vitamin B2), Niacin (Vitamin B3), Pantothenic acid (Vitamin B5), Calcium, Phosphorus, Potassium, Sodium, Selenium, Iron, Copper and Zinc which are necessary to maintain the growth, body functions as well as protected against chronic diseases.
According to Dr. Martin KR., ergothioneine (ERT), a novel antioxidant, presented in edible mushrooms, accumulated through diet was found effective in interrupted pro-inflammatory induction of adhesion molecule expression associated with atherogenesis(1).
Its antioxidants such as Astraodorol, Psilocybin, Lectin, adjusting, ribonuclease, nicotine, etc. may also consist the magic power in reducing the risk and treatment of vary types of cancer, including colon(4), breast, and gastric cancers(5) through inhibition of cell cycle arrest, significant suppression of cellular proliferation, in tested cancer cell lines.
These findings showed support for the notion of dietary mushrooms in the protection of CVD, but multi-canters and large sample size studies to identify the main ingredients comparable to the current medicine used are necessary to improve its validation.
But, the study of the University of Gdańsk, in the reviews and updates data on macro and trace elements and radionuclides in edible wild-grown and cultivated mushrooms suggested that the coexistence of minerals of nutritional value collected from natural habitats, and co-occurrence with some hazardous elements including Cd, Pb, Hg, Ag, As, and radionuclides should be taken certain precautions(6).
Taken altogether, white button mushrooms may be considered a functional food for the prevention and treatment of cardiovascular diseases, depending on the confirmation of the larger sample size and multi-center human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The bioactive agent ergothioneine, a key component of dietary mushrooms, inhibits monocyte binding to endothelial cells characteristic of early cardiovascular disease by Martin KR.(PubMed)
(2) Both common and specialty mushrooms inhibit adhesion molecule expression and in vitro binding of monocytes to human aortic endothelial cells in a pro-inflammatory environment by Martin KR.(PubMed)
(3) Macro and trace mineral constituents and radionuclides in mushrooms: health benefits and risks. by Falandysz J1, Borovička J.(PubMed)
(4) Intracellular trafficking and release of intact edible mushroom lectin from HT29 human colon cancer cells Lu-Gang Yu1, David G. Fernig2 an Jonathan M. Rhodes (The Febs Journal)
(5) Commonly consumed and specialty dietary mushrooms reduce cellular proliferation in MCF-7 human breast cancer cells by Martin KR1, Brophy SK. (PubMed)
(6) Macro and trace mineral constituents and radionuclides in mushrooms: health benefits and risks. by Falandysz J1, Borovička J.(PubMed)
(7) Fruit and vegetable consumption and all-cause, cancer and CVD mortality: analysis of Health Survey for England data by Oyebode O1, Gordon-Dseagu V, Walker A, Mindell JS. (PubMed)
(8) Seasonal consumption of salad vegetables and fresh fruit in relation to the development of cardiovascular disease and cancer by Cox BD1, Whichelow MJ, Prevost AT. (PubMed)
(9) Intakes of fruits, vegetables, and carbohydrates and the risk of CVD by Joshipura KJ1, Hung HC, Li TY, Hu FB, Rimm EB, Stampfer MJ, Colditz G, Willett WC. (PubMed)
(10) Relationships between Obesity and Cardiovascular Diseases in Four Southern States and Colorad by Luma Akil, PhD-C, Candidate and H. Anwar Ahmad, Ph.D., MBA, MCIS, Faculty. (PMC)
Scientists may have found one of the natural food used in many different cultures with the potential in reduced risk and protected against CVD.
Cardiovascular disease (CVD) is a group of conditions associated with the abnormal functioning of the heart and blood vessels.
The causes of cardiovascular diseases are associated with certain prevalent risk factors, including metabolic syndrome, diabetes, and prediabetes, smoking, family history, increase in age, and being overweight or obese.
Some researchers suggested that the coincidence of overweight and obesity and cardiovascular diseases have increased proportionally over a few decades probably correlated to the promotion of the Western diet with high fat, salts, and sugar.
Dr. Luma Akil, the lead author in the concerns of the obesity causes of elevated cardiovascular disease (CVD) mortality and morbidity among American adults conducted an. examination of the associations between the increase in body mass index (BMI) and the increased rates of CVD and high blood pressure (HBP) in the states of Mississippi, Alabama, Louisiana, Tennessee, and Colorado
The study included the data from the Behavioral Risk Factor Surveillance System that were obtained and analyzed for obesity rates, percent of myocardial infarction, stroke, and HBP from 2005–2009.
Using regression analysis, researchers found that the highest rates of obesity, CVD, and HBP were found in Mississippi, while Colorado had the lowest rates.
The result suggested that maintaining a healthy weight helps reduce the risks of developing CVD and obesity is among the leading causes of elevated cardiovascular disease (CVD) mortality and morbidity.
In other words, regular consumption of fruits and vegetables is strongly associated with a reduced risk of cardiovascular disease (CVD). Dietary fungi, such as mushrooms, can protect against chronic disease by altering inflammatory environments through inhibition of cellular processes under pro-inflammatory conditions which are associated with CVD,
Mushroom, a standard name for white button mushroom, is the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source, contains several important nutrients including Thiamine (Vitamin B1), Riboflavin (Vitamin B2), Niacin (Vitamin B3), Pantothenic acid (Vitamin B5), Calcium, Phosphorus, Potassium, Sodium, Selenium, Iron, Copper and Zinc which are necessary to maintain the growth, body functions as well as protected against chronic diseases.
According to Dr. Martin KR., ergothioneine (ERT), a novel antioxidant, presented in edible mushrooms, accumulated through diet was found effective in interrupted pro-inflammatory induction of adhesion molecule expression associated with atherogenesis(1).
Its antioxidants such as Astraodorol, Psilocybin, Lectin, adjusting, ribonuclease, nicotine, etc. may also consist the magic power in reducing the risk and treatment of vary types of cancer, including colon(4), breast, and gastric cancers(5) through inhibition of cell cycle arrest, significant suppression of cellular proliferation, in tested cancer cell lines.
These findings showed support for the notion of dietary mushrooms in the protection of CVD, but multi-canters and large sample size studies to identify the main ingredients comparable to the current medicine used are necessary to improve its validation.
But, the study of the University of Gdańsk, in the reviews and updates data on macro and trace elements and radionuclides in edible wild-grown and cultivated mushrooms suggested that the coexistence of minerals of nutritional value collected from natural habitats, and co-occurrence with some hazardous elements including Cd, Pb, Hg, Ag, As, and radionuclides should be taken certain precautions(6).
Taken altogether, white button mushrooms may be considered a functional food for the prevention and treatment of cardiovascular diseases, depending on the confirmation of the larger sample size and multi-center human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The bioactive agent ergothioneine, a key component of dietary mushrooms, inhibits monocyte binding to endothelial cells characteristic of early cardiovascular disease by Martin KR.(PubMed)
(2) Both common and specialty mushrooms inhibit adhesion molecule expression and in vitro binding of monocytes to human aortic endothelial cells in a pro-inflammatory environment by Martin KR.(PubMed)
(3) Macro and trace mineral constituents and radionuclides in mushrooms: health benefits and risks. by Falandysz J1, Borovička J.(PubMed)
(4) Intracellular trafficking and release of intact edible mushroom lectin from HT29 human colon cancer cells Lu-Gang Yu1, David G. Fernig2 an Jonathan M. Rhodes (The Febs Journal)
(5) Commonly consumed and specialty dietary mushrooms reduce cellular proliferation in MCF-7 human breast cancer cells by Martin KR1, Brophy SK. (PubMed)
(6) Macro and trace mineral constituents and radionuclides in mushrooms: health benefits and risks. by Falandysz J1, Borovička J.(PubMed)
(7) Fruit and vegetable consumption and all-cause, cancer and CVD mortality: analysis of Health Survey for England data by Oyebode O1, Gordon-Dseagu V, Walker A, Mindell JS. (PubMed)
(8) Seasonal consumption of salad vegetables and fresh fruit in relation to the development of cardiovascular disease and cancer by Cox BD1, Whichelow MJ, Prevost AT. (PubMed)
(9) Intakes of fruits, vegetables, and carbohydrates and the risk of CVD by Joshipura KJ1, Hung HC, Li TY, Hu FB, Rimm EB, Stampfer MJ, Colditz G, Willett WC. (PubMed)
(10) Relationships between Obesity and Cardiovascular Diseases in Four Southern States and Colorad by Luma Akil, PhD-C, Candidate and H. Anwar Ahmad, Ph.D., MBA, MCIS, Faculty. (PMC)
#Phytochemical #Allicin Inhibts the Risk of #PancreaticCancer by Stimulating the Immune Cells, Killing Cancer Cells and Natural Killer Cells, Scientists Say
Kyle J. Norton
Scientists may have found a single ingredient isolated from garlic for the prevention and treatment of pancreatic cancer with no side effects, according to studies.
Cancer of the pancreas or pancreatic cancer is a medical condition of a malignant neoplasm of the pancreas, as the cells have become cancerous and divided uncontrollably.
Most pancreatic cancers start in the ducts (an exocrine component of the pancreas) that carry pancreatic juices. Pancreatic cancers originating in the glandular tissue account for over 75 - 90% of all cases of exocrine cancers.
At the advanced stage, cancerous cells from the pancreas may travel a distance away to exhibit secondary metastasis.
In Canada, the 5-year net survival including all stages of pancreatic cancer is 8%. In other words, 92% of people diagnosed with pancreatic cancer will die after 5 years.
According to the statistic provided by the American Cancer Society, every year, approximately an estimated 55,000 adults (29,000 men and 26,000 women) in the United States are diagnosed with pancreatic cancer. The incidence rates are 25% higher in black people, compared to white people.
Researchers do not know the causes of the disease. However, age, gender, ethnicity, smoking habit, poor diet, and certain medical condition such as diabetes are associated with the prevalent risks of pancreatic cancer.
Some researchers suggested that pancreatic cancer is also found in high numbers in obese patients and patients with a family history of the disease, compared to others.
Dr. Silverman DT in the assessment of risk factors for pancreatic cancer, in a population-based case-control study of pancreatic cancer diagnosed in Atlanta (GA), Detroit (MI), and ten New Jersey counties from August 1986 through April 1989, including 526 incident cases and 2,153 population controls. wrote, "elevated body mass index and caloric intake had increased risk".
And, " A three-fold risk of pancreatic cancer among first-degree relatives of affected individuals was apparent. Increased risk also was associated with a family history of colon, endometrial, ovary, and breast cancer, suggesting a possible link to hereditary non-polyposis colon cancer".
Allicin is phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in onion and garlic.
On finding the natural compound for the treatment of pancreatic cancer with no side effects, researchers evaluated the efficacy of combined treatment of the recombinant interleukin-2 (rIL-2) and allicin on pancreatic cancer.
The study includes a total of 60 C57/BL6 nude mice pancreatic cancer xenograft models randomized and assigned into four groups of 15 mice per group: control group, allicin treatment group, rIL-2 treatment group, combined treatment with allicin, and rIL-2 group.
Mice in each group were treated with saline, rIL-2, allicin, or a combination of rIL-2 and allicin by weekly i.v injection for four weeks.
Treatment with the allicin and rIL-2 group significantly suppressed the xenograft growth and prolonged survival time, compared to other groups. Truly, the combined therapy group exerted the most amounts of apoptotic cells.
The combined treatment group anti-pancreatic cancer efficacy was attributed to the activation of levels of CD4+T, in stimulating other immune cells, killing cancer cells, and natural killer cells.
Furthermore, allicin and rIL-2 also increased the levels of Interferon-gamma (IFN-γ), a cytokine produced by a variety of cells involved in the immune response against cancer cells, compared to other groups.
Dr. the lead researcher wrote in the final paper, "Combined treatment with allicin and rIL-2 resulted in suppression of tumor growth and prolonged survival time possibly through activation of CD4+T, CD8+T and NK cell".
Taken together, allicin isolated from garlic may be considered a bioactive ingredient for the prevention and combined with the primary therapy for the treatment of pancreatic cancer.
However, intake of allicin in the form of a supplement should be taken with extreme care in the prevention of overdose toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.References
(1) Effect of combined treatment with recombinant interleukin-2 and allicinon pancreatic cancer by Wang CJ, Wang C, Han J, Wang YK, Tang L, Shen DW, Zhao Y, Xu RH, Zhang H.(PubMed)
(2) Anti-proliferation activity of synthetic ajoene analogues on cancer cell-lines by Kaschula CH, Hunter R, Hassan HT, Stellenboom N, Cotton J, Zhai XQ, Parker MI.(PubMed)
(3) Risk factors for pancreatic cancer: a case-control study based on direct interviews by Silverman DT1. (PubMed)
Scientists may have found a single ingredient isolated from garlic for the prevention and treatment of pancreatic cancer with no side effects, according to studies.
Cancer of the pancreas or pancreatic cancer is a medical condition of a malignant neoplasm of the pancreas, as the cells have become cancerous and divided uncontrollably.
Most pancreatic cancers start in the ducts (an exocrine component of the pancreas) that carry pancreatic juices. Pancreatic cancers originating in the glandular tissue account for over 75 - 90% of all cases of exocrine cancers.
At the advanced stage, cancerous cells from the pancreas may travel a distance away to exhibit secondary metastasis.
In Canada, the 5-year net survival including all stages of pancreatic cancer is 8%. In other words, 92% of people diagnosed with pancreatic cancer will die after 5 years.
According to the statistic provided by the American Cancer Society, every year, approximately an estimated 55,000 adults (29,000 men and 26,000 women) in the United States are diagnosed with pancreatic cancer. The incidence rates are 25% higher in black people, compared to white people.
Researchers do not know the causes of the disease. However, age, gender, ethnicity, smoking habit, poor diet, and certain medical condition such as diabetes are associated with the prevalent risks of pancreatic cancer.
Some researchers suggested that pancreatic cancer is also found in high numbers in obese patients and patients with a family history of the disease, compared to others.
Dr. Silverman DT in the assessment of risk factors for pancreatic cancer, in a population-based case-control study of pancreatic cancer diagnosed in Atlanta (GA), Detroit (MI), and ten New Jersey counties from August 1986 through April 1989, including 526 incident cases and 2,153 population controls. wrote, "elevated body mass index and caloric intake had increased risk".
And, " A three-fold risk of pancreatic cancer among first-degree relatives of affected individuals was apparent. Increased risk also was associated with a family history of colon, endometrial, ovary, and breast cancer, suggesting a possible link to hereditary non-polyposis colon cancer".
Allicin is phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in onion and garlic.
On finding the natural compound for the treatment of pancreatic cancer with no side effects, researchers evaluated the efficacy of combined treatment of the recombinant interleukin-2 (rIL-2) and allicin on pancreatic cancer.
The study includes a total of 60 C57/BL6 nude mice pancreatic cancer xenograft models randomized and assigned into four groups of 15 mice per group: control group, allicin treatment group, rIL-2 treatment group, combined treatment with allicin, and rIL-2 group.
Mice in each group were treated with saline, rIL-2, allicin, or a combination of rIL-2 and allicin by weekly i.v injection for four weeks.
Treatment with the allicin and rIL-2 group significantly suppressed the xenograft growth and prolonged survival time, compared to other groups. Truly, the combined therapy group exerted the most amounts of apoptotic cells.
The combined treatment group anti-pancreatic cancer efficacy was attributed to the activation of levels of CD4+T, in stimulating other immune cells, killing cancer cells, and natural killer cells.
Furthermore, allicin and rIL-2 also increased the levels of Interferon-gamma (IFN-γ), a cytokine produced by a variety of cells involved in the immune response against cancer cells, compared to other groups.
Dr. the lead researcher wrote in the final paper, "Combined treatment with allicin and rIL-2 resulted in suppression of tumor growth and prolonged survival time possibly through activation of CD4+T, CD8+T and NK cell".
Taken together, allicin isolated from garlic may be considered a bioactive ingredient for the prevention and combined with the primary therapy for the treatment of pancreatic cancer.
However, intake of allicin in the form of a supplement should be taken with extreme care in the prevention of overdose toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.References
(1) Effect of combined treatment with recombinant interleukin-2 and allicinon pancreatic cancer by Wang CJ, Wang C, Han J, Wang YK, Tang L, Shen DW, Zhao Y, Xu RH, Zhang H.(PubMed)
(2) Anti-proliferation activity of synthetic ajoene analogues on cancer cell-lines by Kaschula CH, Hunter R, Hassan HT, Stellenboom N, Cotton J, Zhai XQ, Parker MI.(PubMed)
(3) Risk factors for pancreatic cancer: a case-control study based on direct interviews by Silverman DT1. (PubMed)
#Butanolic Extract of #Apricot Shows a Profound Effects in Reducing the Risk of #ColonCancer, Scientists Find
Apricots may be the next generation of whole food medicine for the prevention and treatment of colon cancer, some studies suggested.
Colon cancer is a medical condition characterized by cell growth disorderly and irregularly in the tissue of the colon as a result of the alternation of DNA of the healthy cells.
Most case of colon cancer starts on the surfaced cells of the inner lining of the colon tissue. However, at the later stage, the cancerous cells of the colon can travel a distance away to infect other healthy tissue and organs.
The colon also known as the large bowel or large intestine is an organ that involves the absorption of water from the small bowel contents and breaks down certain materials in the feces into substances in which some of them to be reabsorbed and reused by the body.
The causes of colon cancer are unknown, However, researchers do know that age, family history, ethnicity, overweight or obesity, excessive alcohol drinking, and long-term use of tobacco are the most common risk factors of colon cancer.
Some researchers suggested that good and poor choices of diet may have potential effects to reduce and contribute to the risk of colon cancer.
People who follow the Western diet are not only associated to higher risk but also the recurrent risk of colon cancer onset.
Dr. Alan Moss, the lead author in the study "The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations" wrote, "Processed meat is carcinogenic to humans and lists processed meat as a group 1 substance. Processed meats result from salting, smoking, fermenting, or curing the meat, and common examples include ham, bacon, and sausage.5 Furthermore, red meat was declared as probably carcinogenic to humans, and red meat was listed as a group 2A substance.4 Red and processed meats are considered significant components of a “Western” diet. Other consumed substances that are associated with an increased risk of CRC include alcohol6 and tobacco".
On the other hand in support of the healthy diet choice in the reduction of colon cancer risk, Dr.Jessie A. Satia, the lead scientist said, "The fruit-vegetable and metropolitan patterns were associated with more healthful dietary behaviors (e.g., higher vegetable intake and lower red meat consumption), and demographic/lifestyle characteristics typically correlated with low colon cancer risk".
The apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belongs to the family Rosaceae.
Apricot is classified with the family o plum and has yellow to orange, often tinged red on the side which is exposed to the sun.
The chemical constituents of apricot include
Oleic acid, linoleic acid, palmitic.acid, glycolipids, phospholipids, benzoic acid (I), isorhamnetin (II), quercetin (III), kaempferol-3-O-beta-D-galactopyranoside (IV), isorhamnetin-3-O-beta-D-glucopyranoside (V), isoquercitrin (VI), hypericin (VII) and rutin (VIII)(a) and flavonoid glycosides.
Dr. Fahima Rashid, the lead author in the finding of natural and bioactive food sources with no side effects suggested that the butanolic extract may have a profound effect in reducing the risk of colon cancer by inhibiting the expression of Gram-positive and Gram-negative bacteria.
The antibacterial effect of the extract was attributed to the presence of bioactive Flavonoid glycoside.
Futhermore, in the investigation of the anti-neoplastic effects of MK615, an extract from the Japanese apricot (Prunus mume), against 3 colon cancer cell lines, SW480, COLO, and WiDr, cultured with MK615, researchers found that
* MK615 inhibited growth and lysed SW480, COLO, and WiDr cells in a dose-dependent manner.
* MK615 induced apoptosis after 6 h incubation, at which point the occurrence of apoptotic cells was 68.0%, 65.7%, and 64.7% for SW480, COLO, and WiDr cells, respectively.
* MK615 induced cell death through massive cytoplasmic vacuoles (autophagosomes) in all three cell lines.
Dr. Mori S, the lead author wrote in the final report, "MK615 has an anti-neoplastic effect against colon cancer cells. The effect may be exerted by the induction of apoptosis and autophagy".
Taken altogether, apricot may be considered a functional food for the prevention and treatment of colon cancer.
However, further data collection large example size and multi-center studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of apricot anti-colon cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Flavonoid glycosides from Prunus armeniaca and the antibacterial activity of a crude extract.Rashid F1, Ahmed R, Mahmood A, Ahmad Z, Bibi N, Kazmi SU. (PubMed)
(2) New anti-proliferative agent, MK615, from Japanese apricot "Prunusmume" induces striking autophagy in colon cancer cells in vitro by Mori S1, Sawada T, Okada T, Ohsawa T, Adachi M, Keiichi K.(PubMed)
(3) The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations
Alan Moss and Kumanan Nalankilli. (Gastro enterology)
(4) Dietary Patterns and Colon Cancer Risk in Whites and African Americans in the North Carolina Colon Cancer Study by Jessie A. Satia, Marilyn Tseng, Joseph A. Galanko, Christopher Martin, and Robert S. Sandler (PMC)
#Phytochemical 3,3'-#Diindolylmethane Shows a Low Micromolar Activity Against Resistant #Glioblastoma Cells, According to Studies
Kyle J. Norton
Glioblastoma or glioblastoma (also called GBM) is caused mostly by abnormal astrocytic cells and dead cells (necrosis) and is considered one of the most aggressive cancers induced by the alternation of cells originating from the brain, including the cerebral hemispheres.
Although the disease does not have some specific symptoms, it shares the common symptoms of other types of cancer such as gastrointestinal discomforts accompanied by personality changes, and symptoms similar to those of a stroke.
Most patients with GBM experience symptoms of brain swelling caused by the overexpression of the fluid surrounding the tumor.
Conventionally, due to the nature of rapid growth, surgery is necessary to relieve the brain pressure and remove the tumor as much as possible, followed by radiation and chemotherapy.
According to the statistics, in the US, the incidence affects mostly in the elderly with the diagnosed rate of 3.19 per 100,000 persons. The disease is rare in children.
GBM is deadly, patients with GBM have a median survival of less than one year and less than 2% of patients survive three years or more.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.
Ahtough, 3,3'-Diindolylmethane (DIM) presents health benefits such as antitumor, antioxidant, and anti-inflammatory effects), it is water insoluble and thermo- and photolabile, that restrains its pharmaceutical applications.
In finding a natural bioactive compound isolated from the plant for the treatment of glioblastoma (GBM) researchers examined the DIM-loaded nanocapsules (NCs) prepared with different compositions scavenging activity and cytotoxicity.
In a human glioblastoma cell line (U87 cells), the administration of DIM-loaded nanocapsules (NCs) exerted significant effects in the activation of free radical cytotoxicity against the cell without causing harm to the healthy cells.
According to assays, the nanoencapsulation (NCs) promoted a sustained release of the bioactive compound in the range of 58-78% after 84 h against the tested U87 cells, compared to its free form of 86% after 12 h.
Furthermore, in the highest concentrations, NCs provided a superior cytotoxic effect against the U87 cells.
In other words, the inhibition of U87 cells is proportional to the concentration NCs.
Dr. Mattiazzi J, the lead scientist said, " Our results suggest that nanoencapsulation could be a promising approach to overcome the DIM physicochemical limitations and potentialize its biological properties".
The results suggested NCs may provide a stable condition for the release of DIM against glioblastoma cells,
Furthermore, in the concern of the prognosis for glioblastoma patients median time of survival after diagnosis measured in months, researchers examined other mechanisms of DIM anti glioblastoma cell activity.
In culture, SAR, a series of indole-3-carbinol, particularly, DIM displayed a low micromolar activity against resistant glioblastoma cells.
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and combined with primary medicine for the treatment of glioblastoma and resistant glioblastoma, pending the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Incorporation of 3,3'-Diindolylmethane into Nanocapsules Improves Its Photostability, Radical Scavenging Capacity, and Cytotoxicity Against Glioma Cells by Mattiazzi J1, Sari MHM1, Lautenchleger R1, Dal Prá M2, Braganhol E2, Cruz L. (PubMed)
(2) Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells by Sherer C1, Tolaymat I2, Rowther F3, Warr T3, Snape TJ. (PubMed)
Glioblastoma or glioblastoma (also called GBM) is caused mostly by abnormal astrocytic cells and dead cells (necrosis) and is considered one of the most aggressive cancers induced by the alternation of cells originating from the brain, including the cerebral hemispheres.
Although the disease does not have some specific symptoms, it shares the common symptoms of other types of cancer such as gastrointestinal discomforts accompanied by personality changes, and symptoms similar to those of a stroke.
Most patients with GBM experience symptoms of brain swelling caused by the overexpression of the fluid surrounding the tumor.
Conventionally, due to the nature of rapid growth, surgery is necessary to relieve the brain pressure and remove the tumor as much as possible, followed by radiation and chemotherapy.
According to the statistics, in the US, the incidence affects mostly in the elderly with the diagnosed rate of 3.19 per 100,000 persons. The disease is rare in children.
GBM is deadly, patients with GBM have a median survival of less than one year and less than 2% of patients survive three years or more.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.
Ahtough, 3,3'-Diindolylmethane (DIM) presents health benefits such as antitumor, antioxidant, and anti-inflammatory effects), it is water insoluble and thermo- and photolabile, that restrains its pharmaceutical applications.
In finding a natural bioactive compound isolated from the plant for the treatment of glioblastoma (GBM) researchers examined the DIM-loaded nanocapsules (NCs) prepared with different compositions scavenging activity and cytotoxicity.
In a human glioblastoma cell line (U87 cells), the administration of DIM-loaded nanocapsules (NCs) exerted significant effects in the activation of free radical cytotoxicity against the cell without causing harm to the healthy cells.
According to assays, the nanoencapsulation (NCs) promoted a sustained release of the bioactive compound in the range of 58-78% after 84 h against the tested U87 cells, compared to its free form of 86% after 12 h.
Furthermore, in the highest concentrations, NCs provided a superior cytotoxic effect against the U87 cells.
In other words, the inhibition of U87 cells is proportional to the concentration NCs.
Dr. Mattiazzi J, the lead scientist said, " Our results suggest that nanoencapsulation could be a promising approach to overcome the DIM physicochemical limitations and potentialize its biological properties".
The results suggested NCs may provide a stable condition for the release of DIM against glioblastoma cells,
Furthermore, in the concern of the prognosis for glioblastoma patients median time of survival after diagnosis measured in months, researchers examined other mechanisms of DIM anti glioblastoma cell activity.
In culture, SAR, a series of indole-3-carbinol, particularly, DIM displayed a low micromolar activity against resistant glioblastoma cells.
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and combined with primary medicine for the treatment of glioblastoma and resistant glioblastoma, pending the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Incorporation of 3,3'-Diindolylmethane into Nanocapsules Improves Its Photostability, Radical Scavenging Capacity, and Cytotoxicity Against Glioma Cells by Mattiazzi J1, Sari MHM1, Lautenchleger R1, Dal Prá M2, Braganhol E2, Cruz L. (PubMed)
(2) Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells by Sherer C1, Tolaymat I2, Rowther F3, Warr T3, Snape TJ. (PubMed)
#T[6]-gingerol and [6]-shogaol Found in #Ginger Relieve #ChronicPain Associated with Pain Sensation and Sensory Neurons
Kyle J. Norton
Pain is a natural reflex of the body caused by the distress signal due to intense or damaging stimuli, transmitted by the central nervous system with an aim to protect against damage.
However, according to pain management, pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage.
In other words, pains can be transmitted by the CNS due to the previous pain experience, including false alarms.
Pain can be classified into several types, including
* Nociceptive pain arises due to the actual damage of the body tissue transmitted by the nerves to the brain.
and
* Neuropathic pain arises from damage to the nervous system, caused by actual damage to nerve cells or neurons.
Chronic pain is a pain that lasts more than 3 months. There is a general belief that people who fatigue, sleep disturbance, decreased appetite, and mood changes, are often also accompanied by chronic pain.
Pain relief is the use of a substance including medicines for reducing pain.
Conventionally, the goal of treatment of chronic pain is to reduce pain and improve function, so the person can resume day-to-day activities. In other words, the aim of treatment in conventional treatment is to improve the quality of life and physical activity by managing the pain in such a way depending on the type of chronic pain.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound that processes pain relief properties with no side effects Researchers investigated the effects of prophylactic administration of zerumbone (Zer, ginger) on allodynia and hyperalgesia in a mouse model of chronic constriction injury (CCI)-induced neuropathic pain.
According to the tested assays, injection of Zer at the doses of 10 and 50 mg/kg attenuated pain symptoms on all days without any signs of sedation in the rotarod test at ED50 values.
The same doses also decreased the mechanical allodynia, cold allodynia, thermal hyperalgesia, and mechanical hyperalgesia were 9.25, 9.507, 8.289, and 9.801 mg/kg, respectively.
According to the blood sample, the efficacy of ginger in the reduction of pain was probably associated with the inhibition of spinal levels of proinflammatory cytokines, including IL-1β, IL-6, and tumor necrosis factor-α.
Dr. Gopalsamy B, the lead scientist said, "Zer exhibits its antiallodynic and antihyperalgesic properties via reduced sensitization at nociceptor neurons possibly through the suppression of inflammatory mediators".
In order to reveal more information about ginger compounds associated with pain relief, researchers examined [6]-gingerol and [6]-shogaol, two components of a processed Ginger extract, the traditional Japanese herbal medicine hangeshashinto (HST) in the inhibition of voltage-activated Na+ currents.
In animal studies, T[6]-gingerol and [6]-shogaol inhibited the stimulant-induced release of substance P, a mediator of pain sensation and action potential generation in cultured rat sensory neurons.
In a rat OUM model, OUM-induced mechanical pain was alleviated 30min after the swab application of HST.
Furthermore, combined with ginseng, a swab application of a mixture of [6]-gingerol. and [6]-shogaol induced sufficient analgesia of OUM-induced mechanical or spontaneous pain.
Based on the finding, Dr. Hitomi S, the lead scientist said, "These findings suggest that Na+ channel blockage by gingerol/shogaol plays an essential role in HST-associated analgesia of OUM-induced pain".
Taken together, ginger processed a high amount of bioactive compounds [6]-gingerol. and [6]-shogaol may be used alone or combined with other herbal remedies for the treatment of pain, pending the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6, and TNF-α in a mouse model of neuropathic pain by Gopalsamy B1, Farouk AAO1, Tengku Mohamad TAS1, Sulaiman MR1, Perimal EK. (PubMed)
(2) [6]-gingerol and [6]-shogaol, active ingredients of the traditional Japanese medicine hangeshashinto, relieve oral ulcerative mucositis-induced pain via action on Na+ channels by Hitomi S1, Ono K2, Terawaki K3, Matsumoto C3, Mizuno K3, Yamaguchi K4, Imai R3, Omiya Y3, Hattori T3, Kase Y3, Inenaga K. (PubMed)
Pain is a natural reflex of the body caused by the distress signal due to intense or damaging stimuli, transmitted by the central nervous system with an aim to protect against damage.
However, according to pain management, pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage.
In other words, pains can be transmitted by the CNS due to the previous pain experience, including false alarms.
Pain can be classified into several types, including
* Nociceptive pain arises due to the actual damage of the body tissue transmitted by the nerves to the brain.
and
* Neuropathic pain arises from damage to the nervous system, caused by actual damage to nerve cells or neurons.
Chronic pain is a pain that lasts more than 3 months. There is a general belief that people who fatigue, sleep disturbance, decreased appetite, and mood changes, are often also accompanied by chronic pain.
Pain relief is the use of a substance including medicines for reducing pain.
Conventionally, the goal of treatment of chronic pain is to reduce pain and improve function, so the person can resume day-to-day activities. In other words, the aim of treatment in conventional treatment is to improve the quality of life and physical activity by managing the pain in such a way depending on the type of chronic pain.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound that processes pain relief properties with no side effects Researchers investigated the effects of prophylactic administration of zerumbone (Zer, ginger) on allodynia and hyperalgesia in a mouse model of chronic constriction injury (CCI)-induced neuropathic pain.
According to the tested assays, injection of Zer at the doses of 10 and 50 mg/kg attenuated pain symptoms on all days without any signs of sedation in the rotarod test at ED50 values.
The same doses also decreased the mechanical allodynia, cold allodynia, thermal hyperalgesia, and mechanical hyperalgesia were 9.25, 9.507, 8.289, and 9.801 mg/kg, respectively.
According to the blood sample, the efficacy of ginger in the reduction of pain was probably associated with the inhibition of spinal levels of proinflammatory cytokines, including IL-1β, IL-6, and tumor necrosis factor-α.
Dr. Gopalsamy B, the lead scientist said, "Zer exhibits its antiallodynic and antihyperalgesic properties via reduced sensitization at nociceptor neurons possibly through the suppression of inflammatory mediators".
In order to reveal more information about ginger compounds associated with pain relief, researchers examined [6]-gingerol and [6]-shogaol, two components of a processed Ginger extract, the traditional Japanese herbal medicine hangeshashinto (HST) in the inhibition of voltage-activated Na+ currents.
In animal studies, T[6]-gingerol and [6]-shogaol inhibited the stimulant-induced release of substance P, a mediator of pain sensation and action potential generation in cultured rat sensory neurons.
In a rat OUM model, OUM-induced mechanical pain was alleviated 30min after the swab application of HST.
Furthermore, combined with ginseng, a swab application of a mixture of [6]-gingerol. and [6]-shogaol induced sufficient analgesia of OUM-induced mechanical or spontaneous pain.
Based on the finding, Dr. Hitomi S, the lead scientist said, "These findings suggest that Na+ channel blockage by gingerol/shogaol plays an essential role in HST-associated analgesia of OUM-induced pain".
Taken together, ginger processed a high amount of bioactive compounds [6]-gingerol. and [6]-shogaol may be used alone or combined with other herbal remedies for the treatment of pain, pending the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6, and TNF-α in a mouse model of neuropathic pain by Gopalsamy B1, Farouk AAO1, Tengku Mohamad TAS1, Sulaiman MR1, Perimal EK. (PubMed)
(2) [6]-gingerol and [6]-shogaol, active ingredients of the traditional Japanese medicine hangeshashinto, relieve oral ulcerative mucositis-induced pain via action on Na+ channels by Hitomi S1, Ono K2, Terawaki K3, Matsumoto C3, Mizuno K3, Yamaguchi K4, Imai R3, Omiya Y3, Hattori T3, Kase Y3, Inenaga K. (PubMed)
The Effects of #Herbal #Alfalfa on Symptoms and Diseases Associated with Estrogen Deficiency, According to Studies
Kyle J. Norton
Herbal Alfalfa may process an estrogenic effect for the treatment of estrogen-deficient diseases and symptoms, some studies found.
The estrogenic effect is an action that stimulates the production of the hormone estrogen in case of deficiency.
Menopause symptoms are a set of symptoms caused by the gradual decline of levels of estrogen and progesterone due to aging loss of menstrual period in women.
The reproductive tract, the urinary tract, the heart and blood vessels, bones, breasts, skin, hair, mucous membranes, and pelvic muscles normally regulated by the hormone estrogen also are affected by the decline levels of the hormone.
In the concern of hormone therapy used for the treatment of menopause symptoms, herbal medicine with estrogenic effect have been under intensive investigation, with an aim to find a natural ingredient with similar effects as those used in hormone therapy with no side effects.
Dr. the lead scientist at the Pan-American Health Organization/World Health Organization Collaborating Centre for Traditional Medicine launched an evaluation to examine the estrogenic activity of seventeen plant species collected and extracted in Costa Rica.
Interestingly, only 6 of the plant extracts bound to the ERs with 4 of the six extracts stimulated reporter gene expression, according to the ER-beta-Chemically Activated Luciferase Expression assay.
Four extracts exerted estrogenic activity and also act as estrogen agonists.
In other words, these extracts induced the production of estrogen when the body needs it and inhibited levels of estrogen when the hormone is overexpressed in the body.
Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae.
The herbal plant has been cultivated all over the world as hay for cattle feeding.
The leaves, sprouts, and seeds to make medicine has been used in traditional medicine over thousands of years to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorders, kidney, urinary tract infections, etc.
North American Aboriginals have used Alfalfa seed as food, such as making bread and mush.
The chemical constituents of alfalfa include flavones, isoflavones, sterols, Bichanin A, Coumestrol Diadzein, Formonetin, Genistein, and coumarin derivatives, etc.
A study to determine whether estrogenic botanical supplement (EBS) use influences breast cancer survivors' health-related outcomes.was conducted by the research team at the Beckman Research Institute.
The study includes 767 breast cancer survivors who filled out the returned questionnaire suggesting that EBS improve quality of life by reducing some of the symptom associated with 15 hormone-related symptoms such as hot flashes and night sweats.
However, Dr. Ma H, the lead author after taking into account of co and confounders said, "Our findings indicate that several specific types of EBS might have important influences on a woman's various aspects of quality of life".
Additionally, in the study to clarify the effect of phytoestrogens in a group of lipophilic plant compounds, researchers launched an investigation to examine examined the proliferative effects of phytoestrogens on a rat pituitary tumor cell line, GH3/B6/F10, originally subcloned from GH3 cells based on its ability to express high levels of the membrane estrogen receptor-alpha.
The phytoestrogen compounds included in the study at a range of different concentrations are coumestrol, daidzein, genistein, and trans-resveratrol.
All four phytoestrogens attenuated the proliferative effects of estradiol when administered simultaneously.
Except for trans-resveratrol, all phytoestrogens increased GH3/B6/F10 cell proliferation at some concentration relevant to dietary levels.
All phytoestrogens exerted significant anti-proliferative activity, but with time course patterns that often differed from that of estradiol and each other.
More importantly, except for trans-resveratrol, a serum removal-induced extrinsic apoptotic pathway was blocked by these phytoestrogens.
These results clearly suggested, the injection of single ingredients of phytochemicals may have both tumorigenic and anti-tumorigenic effects, and intake of the estrogenic whole food which processed all the ingredients exerted a strong anti-tumorigenic activity.
Taken all together, there is no doubt that herbal Alfalfa processed with a strong estrogenic effect may be considered a functional food for the treatment of diseases and symptoms associated with estrogen deficiency.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Drug-induced lupus: an update by Vasoo S.(PubMed)
(2) Estrogenic botanical supplements, health-related quality of life, fatigue, and hormone-related symptoms in breast cancer survivors: a HEAL study report by Ma H, Sullivan-Halley J, Smith AW, Neuhouser ML, Alfano CM, Meeske K, George SM, McTiernan A, McKean-Cowdin R, Baumgartner KB, Ballard-Barbash R, Bernstein L.(PubMed)
(3) Proliferative and antiproliferative effects of dietary levels of phytoestrogens in rat pituitary GH3/B6/F10 cells - the involvement of rapidly activated kinases and caspases by Jeng YJ, Watson CS.(PubMed)
Herbal Alfalfa may process an estrogenic effect for the treatment of estrogen-deficient diseases and symptoms, some studies found.
The estrogenic effect is an action that stimulates the production of the hormone estrogen in case of deficiency.
Menopause symptoms are a set of symptoms caused by the gradual decline of levels of estrogen and progesterone due to aging loss of menstrual period in women.
The reproductive tract, the urinary tract, the heart and blood vessels, bones, breasts, skin, hair, mucous membranes, and pelvic muscles normally regulated by the hormone estrogen also are affected by the decline levels of the hormone.
In the concern of hormone therapy used for the treatment of menopause symptoms, herbal medicine with estrogenic effect have been under intensive investigation, with an aim to find a natural ingredient with similar effects as those used in hormone therapy with no side effects.
Dr. the lead scientist at the Pan-American Health Organization/World Health Organization Collaborating Centre for Traditional Medicine launched an evaluation to examine the estrogenic activity of seventeen plant species collected and extracted in Costa Rica.
Interestingly, only 6 of the plant extracts bound to the ERs with 4 of the six extracts stimulated reporter gene expression, according to the ER-beta-Chemically Activated Luciferase Expression assay.
Four extracts exerted estrogenic activity and also act as estrogen agonists.
In other words, these extracts induced the production of estrogen when the body needs it and inhibited levels of estrogen when the hormone is overexpressed in the body.
Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae.
The herbal plant has been cultivated all over the world as hay for cattle feeding.
The leaves, sprouts, and seeds to make medicine has been used in traditional medicine over thousands of years to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorders, kidney, urinary tract infections, etc.
North American Aboriginals have used Alfalfa seed as food, such as making bread and mush.
The chemical constituents of alfalfa include flavones, isoflavones, sterols, Bichanin A, Coumestrol Diadzein, Formonetin, Genistein, and coumarin derivatives, etc.
A study to determine whether estrogenic botanical supplement (EBS) use influences breast cancer survivors' health-related outcomes.was conducted by the research team at the Beckman Research Institute.
The study includes 767 breast cancer survivors who filled out the returned questionnaire suggesting that EBS improve quality of life by reducing some of the symptom associated with 15 hormone-related symptoms such as hot flashes and night sweats.
However, Dr. Ma H, the lead author after taking into account of co and confounders said, "Our findings indicate that several specific types of EBS might have important influences on a woman's various aspects of quality of life".
Additionally, in the study to clarify the effect of phytoestrogens in a group of lipophilic plant compounds, researchers launched an investigation to examine examined the proliferative effects of phytoestrogens on a rat pituitary tumor cell line, GH3/B6/F10, originally subcloned from GH3 cells based on its ability to express high levels of the membrane estrogen receptor-alpha.
The phytoestrogen compounds included in the study at a range of different concentrations are coumestrol, daidzein, genistein, and trans-resveratrol.
All four phytoestrogens attenuated the proliferative effects of estradiol when administered simultaneously.
Except for trans-resveratrol, all phytoestrogens increased GH3/B6/F10 cell proliferation at some concentration relevant to dietary levels.
All phytoestrogens exerted significant anti-proliferative activity, but with time course patterns that often differed from that of estradiol and each other.
More importantly, except for trans-resveratrol, a serum removal-induced extrinsic apoptotic pathway was blocked by these phytoestrogens.
These results clearly suggested, the injection of single ingredients of phytochemicals may have both tumorigenic and anti-tumorigenic effects, and intake of the estrogenic whole food which processed all the ingredients exerted a strong anti-tumorigenic activity.
Taken all together, there is no doubt that herbal Alfalfa processed with a strong estrogenic effect may be considered a functional food for the treatment of diseases and symptoms associated with estrogen deficiency.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Drug-induced lupus: an update by Vasoo S.(PubMed)
(2) Estrogenic botanical supplements, health-related quality of life, fatigue, and hormone-related symptoms in breast cancer survivors: a HEAL study report by Ma H, Sullivan-Halley J, Smith AW, Neuhouser ML, Alfano CM, Meeske K, George SM, McTiernan A, McKean-Cowdin R, Baumgartner KB, Ballard-Barbash R, Bernstein L.(PubMed)
(3) Proliferative and antiproliferative effects of dietary levels of phytoestrogens in rat pituitary GH3/B6/F10 cells - the involvement of rapidly activated kinases and caspases by Jeng YJ, Watson CS.(PubMed)
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