#KelulutHoney (KH) Processes Chemopreventive Properties and Anti-Chemo Toxicity During Cancer Treatment, According to Studies

Kyle J. Norton

Honey may be considered an adjunct therapy combined with the chemo drug in the improvement of the drug efficacy and reduction of chemo toxicity for the treatment of cancers, some scientists found.

Cancer is a class of chronic diseases characterized by cell growth irregularly and disorderly in the tissue of specific organs, depending on the type of cancer.

Most cases of cancer are the result of the alternation of DNA in the cell located on the surface of the inner lining of an organ. Most patients may not experience any symptoms at an early stage.

However, as cancer progresses, the continued growth of tumors may cause pressure on the nearby healthy organs and nerve cells, leading to localized symptoms and severe pain.

At the 4th stage of cancer, malignant cells may metastasize to other organs a distance away from the original site.

According to the statistic from the National Cancer Institute, approximately, 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes.

In 2017, over 15,000 children and adolescents ages 0 to 19 were diagnosed with cancer, and 1,790 died of the disease.
Chemo drugs are medicine used for the treatment of cancer by killing cancer cells that have been spread to other tissue or organ.

Chemotoxicity is the side effect of chemo drugs.

The most common symptoms of chemo drugs include the effect of blood-forming cells in the bone marrow, on hair follicles and cells in the mouth, digestive tract, and reproductive system, probably due to the medicine designed to kill cells indiscriminately.

According to the information from the pharmaceutical company, doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented by mankind.

The chemo drug used to treat a wide variety of cancers can kill cancer at every point in their life cycle.
Unfortunately, the drug can also damage heart cells and cause serious side effects, such as hair loss, breathlessness, and feeling sick and easily infected.
Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered healthy sweet food for replacing the use of white sugar and artificial sweetener many people.

In finding a natural ingredient or whole food which processes chemopreventive properties and anti-chemo toxicity during cancer treatment, researchers evaluate the effect of Kelulut honey (KH), produced by the stingless bees from Trigona species against colon cancer induced in the animal model.

A total of 24 male Sprague Dawley rats aged 5 weeks are included in the study.
Rats were divided into 4 groups: (G1) untreated group not induced with AOM, (G2) untreated group induced with AOM, (G3) treated group induced with AOM, and (G4) treated group not induced with AOM.
Injection of AOM (15 mg/kg) was via intraperitoneal route once a week for two subsequent weeks to induce colorectal cancer.
The treatment groups were given oral administration of KH (1183 mg/kg body weight) twice daily for 8 weeks.

AOM injected group showed a significant increase in the total number of aberrant crypt foci (ACF) and aberrant crypts (AC) and crypt multiplicity and damage of liver and kidney

After treatment of KH, the AOM group displayed a reduction of crypts and chemotoxicity by restoring the liver and kidney function observed by the blood profile.

Furthermore, KH was not toxically identified by the KH-treated group not induced with AOM.

These results suggested that KH may have a potential effect on inhibiting the toxicity caused by chemotherapy and improving the chemo drugs' activity without inducing any side effects.

Moreover, on finding a natural whole food to overcome 5-fluorouracil (5-FU) therapeutic resistance and adverse toxicity in colorectal cancer, researchers looked into Manuka honey (MH), a rich source of bioactive compounds to examine its anticancer effects on human colon cancer HCT-116 and LoVo cells.

Compared to 5-FU alone, MH synergistically enhanced the chemotherapeutic effects of 5-FU, by reducing cell proliferation through the suppression of enzymes and proteins associated with the function of stimulating cancer cell multicity and activation of pathways associated with cell death programming.

Combined with chemo drug 5-FU, MH promoted the expression of antibody production and production of ROS in the induction of cytotoxicity activity against cancer cells without causing harm to the nearby cells and tissue.

This result was observed by the reducing antioxidants produced by the cancer cells and increasing oxidative stress in the tumor.

Additionally, MH also induced cancer cell apoptosis through cell cycle arrest.

The findings clearly indicated MH could be a useful preventive or adjuvant agent in the treatment of colorectal cancer with 5-FU by inhibiting toxicity and cancer cell resistance.

Taken altogether, KH and MH can be considered functional foods for the prevention and adjunct therapy combined with the primary medicine for the treatment of cancer without inducing chemotoxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Ovarian Cysts And PCOS Elimination
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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Chemopreventive Properties and Toxicity of Kelulut Honey in Sprague Dawley Rats Induced with Azoxymethane by Saiful Yazan L1, Muhamad Zali MF2, Mohd Ali R3, Zainal NA2, Esa N4, Sapuan S4, Ong YS4, Tor YS4, Gopalsamy B2, Voon FL2, Syed Alwi SS. (PubMed)
(2) Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes, and suppressing metastasis ability by Afrin S1, Giampieri F1, Forbes-Hernández TY1, Gasparrini M1, Amici A1, Cianciosi D1, Quiles JL2, Battino M. (PubMed)

Oral #Ginger Shows A Strong Effect In Inhibiting the Symptoms of #MenstrualPain in #Dysmenorrhea, Researchers Suggest

Kyle J. Norton

Ginger may be the next generation of natural whole food for the prevention and treatment of menstrual pain, some scientists found.
Dysmenorrhea is a menstrual pain is pain occurred around a few days before menstruation begins.

The symptom normally lasts less than three days.

There are 2 types of dysmenorrhea
* Primary dysmenorrhea is a painful period with no other condition occurred most in adolescence, affecting over 90% of women in the prime time of their reproductive years. In adolescence, some researchers suggested the symptoms are associated with immature reproductive organs.

* Secondary dysmenorrhea is the painful period associated with the disorder in the woman's reproductive organs, such as endometriosis, adenomyosis, uterine fibroids, or infection.

Some women affected by the painful period may experience symptoms of It occurs in your lower abdominal pain can be felt in the hips, lower back, or thighs.

Other common symptoms may include nausea, vomiting, diarrhea, lightheadedness, headache, or fatigue.

There is no cure for dysmenorrhea. Nonsteroidal anti-inflammatory drugs (NSAIDs), the most common treatment for both primary and secondary dysmenorrhea may be effective, however, the drugs can induce some serious side effects, including liver or kidney problems. and hypertension.

If you are currently using conventional medicine for the treatment of dysmenorrhea, please sure you know all the side effects for the preventive measure.
.
In the use of diet therapy for the prevention and treatment of dysmenorrhea, Dr. Dina Abadi Bavil, the lead scientist said, "Given the scores obtained on the lifestyle questionnaire, significant differences were observed between the groups with and without dysmenorrhea in terms of eating behavior (p=0.008), physical activity (p=0.011), stress (p=0.041), and social relationships".


These results clearly suggested that a healthy diet and lifestyle play important roles in the prevention
and treatment of dysmenorrhea

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On findings of a natural ingredient or whole food for the prevention and treatment of dysmenorrhea in the replacement of conventional medicine without inducing side effects, researchers examine the effects of ginger on primary dysmenorrhea, through searching the database of medical literature online.

Six selected studies were reviewed by 2 authors independently.

Ginger appeared more effective for reducing pain severity than placebo.

Ginger was found as effective as those mefenamic acids (an NSAID).

The finding point to one conclusion, oral ginger could be an effective treatment for menstrual pain in dysmenorrhea.

Dr. Daily JW, the lead scientist in another search to find evidence of ginger for treating primary dysmenorrhea launched an investigation by looking into the database of 12 medical libraries.

Seven met specific selection criteria were included in the review.

Four of the RCTs compared the therapeutic efficacy of ginger with placebo during the first 3-4 days of the menstrual cycle and were included in the meta-analysis.
The results of the in-depth differentiation showed that ginger processes had a significant effect in reducing the Pain Visual Analogue Scale (PVAS) in subjects having primary dysmenorrhea.

Six RCTs out of 7 exhibited low to moderate risk of bias.

These results of the RCTs strongly indicated the suggestive evidence for the effectiveness of 750-2000 mg ginger powder during the first 3-4 days of the menstrual cycle for primary dysmenorrhea.

Taken altogether, ginger may be considered a functional remedy for the prevention and treatment of painful period with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(2) Efficacy of Oral Ginger (Zingiber officinale) for Dysmenorrhea: A Systematic Review and Meta-Analysis by Chen CX1, Barrett B2, Kwekkeboom KL3. (PubMed)
(3) Efficacy of Ginger for Alleviating the Symptoms of Primary Dysmenorrhea: A Systematic Review and Meta-analysis of Randomized Clinical Trials by Daily JW1, Zhang X2, Kim DS2, Park S2. (PubMed)
(4) Comparison of lifestyles of young women with and without primary dysmenorrhea by Dina Abadi Bavil,1 Mahrokh Dolatian,2 Zohreh Mahmoodi,3,4 and Alireza Akbarzadeh Baghban. (PMC)

#Arctigenin (ATG) Found in #Herbal #Burdock Exerts Cytotoxicity Activity Against #BreastCancer In Vivo and Vitro, Researchers Say

By Kyle J. Norton

Scientists may have found a whole herb that processes a significant effect in reducing the risk and treatment of breast cancer with no side effects, according to some studies.

Breast cancer is a chronic condition characterized by cell growth controllably and disorderly in the breast tissue.

Most cases of breast cancer start at the cells on the surface of the inner lining tissue of the breast. At this stage, most patients may experience symptoms of lump on part of the breast, swelling, nipple pain and redness, and scaliness. If you have some of the above which can not resolve within 3 weeks, please check with your doctor to rule out the possibility of breast cancer.

At the advanced stage, after penetrating into the deeper layers of the breast, malignant cells may travel a distance far away from the breast to infect other healthy tissue and organs, through the blood and fluids circulation.

In this stage, the breast tumor is growing large enough to suppress the nearby healthy tissue and nerve cells, causing severe localized symptoms and pain.

The liver, brain, bones, or lungs are the most common organs for breast cancer metastasis.

According to a statistic provided by the cancer society, women in Canada have a lifetime risk of breast cancer incidence rates of 11%. In other words, 11% of Canadian women will develop breast cancer by the time they reach 90 years of age.

Only 20% of breast cancers in Canada are diagnosed in women under 50, compared to almost 30% diagnosed in women over 70 years of age.

The 5 years survival rate of breast cancer is 100% compared to 89% in the 10 years survival rate.

Therefore, early diagnosis is a key factor to improve the survival rate and prevent a long-term painful
treatment with many unpleasant side effects if the cancer is found in the later stage.

Women are encouraged to examine their breasts every month if you found any changes that not in 3 not recover within 3 weeks, please check with your doctor as soon as possible.

Burdock is a plant in the group of biennial thistles, genus Arctium, belonging to the family Asteraceae, native to the Euro.

The plant has been used over thousands of years in China and other traditional herbal medicine as a diuretic, diaphoretic, and blood-purifying agent and to treat wounds and infections stomach ulcers, and other digestive problems.

In finding the natural compound with no side effects, researchers examine the anticancer effect of arctigenin (ATG), a natural lignan product of Herbal Burdock (Arctium lappa L.), in human breast cancer MDA-MB-231 cells.

Application of arctigenin (ATG) showed potency in inhibiting the MDA-MB-231 cell growth by inducing apoptosis.

ATG stimulated breast cancer cell death programming by reducing the ratio expression of Bax/Bcl-2.

Furthermore, ATG also activated the overexpression of free radicals in the induction of cytotoxicity to the breast cancer cell line.

These results suggested that ATG induced cancer apoptosis through many different mechanisms, including the pathways in stimulating the expression of ROS that causes cytotoxicity and promotes cell death.

Additionally, in reaffirming the anti-breast cancer of herbal burdock, researchers conducted an experiment to evaluate the anti-cancer properties of Arctiin, a major lignan constituent of Arctium lappa (Burdock) in animal models.

In human breast cancer MCF-7 cells, injection of Arctiin demonstrated a significant effect in the inhibition of the breast cancer cells associated with decreasing the function of the protein in promoting the cell cycle division.

Moreover, the application of Arctiin also increased the function of the protein associated with the suppressor in acting to inhibit cell proliferation and tumor development.

Taken together, Herbal Burdock may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of breast cancer.

However, further data collection large example size and multi-center studies performed with human consumption of the whole food or its bioactive compounds due to the disease will be necessary to complete the picture of herbal Burdock anti-cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To ProfessionalsPrediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS/p38 MAPK pathway and epigenetic regulation by Hsieh CJ, Kuo PL, Hsu YC, Huang YF, Tsai EM, Hsu YL. (PubMed)
(2) Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression by Matsuzaki Y, Koyama M, Hitomi T, Yokota T, Kawanaka M, Nishikawa A, Germain D, Sakai T.(PubMed)

#Phytochemical Indole-3-carbinol Combined with the Anticancer Agent, Gemcitabine For the Treatment of #PancreaticCancer, Researchers Reveal

Kyle J. Norton

Scientists may have found a bioactive compound for the prevention and treatment of pancreatic cancer, according to studies.
Cancer of the pancreas or pancreatic cancer is a condition of a malignant neoplasm of the pancreas.

Most cases of primary pancreatic cancer start in the cells on the surface of the inner lining of the pancreas as a result of irregular cell growth caused by the alternation of DNA.

Pancreatic cancers start in the ducts (an exocrine component of the pancreas) carried pancreatic juices with cancer of an epithelium that originates in glandular tissue and accounts for over 75 - 90% of all cases of exocrine cancers.

According to the statistic, pancreatic cancer is the fourth leading cause of cancer death in both men and women in the US. Cancer has the poorest prognosis compared to other major types of cancer, with a 5-yr survival rate of approximately 5%.

More precisely, in the US, the age-adjusted incidence of pancreatic cancer is higher in men compared to women regardless of ethnicity.

Epidemiologically, the increase in age, gender, ethnicity, smoking, being obese and obese, and certain medical conditions such as diabetes, and family history are associated with an increased risk of pancreatic cancer.

Some researchers suggested that genetic preposition also places the carrier at a greater risk for the onset of the disease.

Dr. Alison P. Klein, in the joint study led by the Johns Hopkins University School of Medicine, Baltimore, Maryland suggested people who carry the mutated gene BRCA2 or PALB2 and genetic variation at the ABO blood group locus are associated with a modest increased risk of pancreatic cancer.
Indole-3-carbinol is a phytochemical in the class of Indoles, by the breaking down of the glucosinolate glucobrassicin, found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.

In finding the natural ingredient for the treatment of pancreatic cancer without inducing chemoresistance due to the overexpression of microRNA-21 (miR-21), researchers at the Seoul National University College of Medicine evaluated the efficacy of indole-3-carbinol (I3C) in suppressing miR-21 expression.

Where miR-21 simultaneously regulates multiple programs that enhance cell proliferation, apoptosis, and tumor invasiveness by targeting the genes associated with cancer proliferation.

In human pancreatic cancer cells (Panc-1), injection of 13C inhibited the expression of miR-21 positively correlated in a time- and dose-dependent manner.

13C and gemcitabine combination therapy increased cytotoxicity in Panc-1 cells.

The efficacy of 13C was attributed to its activity in promoting cancer cell apoptosis by attenuating miR-21 transfection.


The finding suggested that I3C would be effective in enhancing the sensitivity of pancreatic cancer cells to gemcitabine via the inhibition of the overexpression of miR-21.

An additional experiment demonstrating the ability of a dietary agent, indole-3-carbinol (I3C), to lower the LD(50) of gemcitabine (Gemzar) in decreasing growth of both male (MiaPaca2) and female (SU86.86) pancreatic cancer cells, researchers found that* Without an injection of 13C, female pancreatic cancer cells were more resistant to gemcitabine.

* In male MiaPaca2 cells application of 1, 10, or 100 μM of I3C induced apoptosis by reactivating the tumor suppressor gene in pancreatic cancer cells.

* 13C also protects the healthy pancreas cells by enhancing the activity of the tumor suppressor gene.

Moreover, by examing the DNA methylation researchers suggested suppressor tumor gene (p16INK4a) inactivation in the promotion of hypermethylation is considered an early event in pancreatic carcinogenesis.

DNA methylation is a process by which methyl groups are added to the DNA molecule.

These results clearly indicated, I3C, a possible non-toxic hypomethylating agent, combined with the anticancer agent, gemcitabine, is a powerful strategy for treating pancreatic cancer.


Taken altogether, the bioactive compound indole-3-carbinol (I3C) may be used for the prevention and treatment of pancreas cancer, pending the results of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Chemosensitivity induced by down-regulation of microRNA-21 in gemcitabine-resistant pancreatic cancer cells by indole-3-carbinol by Paik WH1, Kim HR, Park JK, Song BJ, Lee SH, Hwang JH.(PubMed)
(2) Gender differences in gemcitabine (Gemzar) efficacy in cancer cells: effect of indole-3-carbinol. by Lyn-Cook BD1, Mohammed SI, Davis C, Word B, Haefele A, Wang H, Hammons G.(PubMed)
(3) Enhanced efficacy of gemcitabine by indole-3-carbinol in pancreatic cell lines: the role of human equilibrative nucleoside transporter 1 by Wang H1, Word BR, Lyn-Cook BD. (PubMed)
(4) Genetic Susceptibility to Pancreatic Cancer by Alison P. Klein. (PMC)

[6]-gingerol Found in #Ginger Inhibit the Formation of AGEs Associated with the Risk of Diabetes in Vivos, According to Studies

Kyle J. Norton

Ginger may have a potential and profound effect in regulating the abnormally high blood sugar, some scientists suggested.
Hyperglycemia is a condition of abnormally high levels of glucose in the bloodstream.

According to the statistic, approximately, 30.3 million Americans, or 9.4% of the population, had diabetes. Approximately 1.25 million American children and adults have type 1 diabetes. And, hyperglycemia is a hallmark sign of diabetes(both type 1 diabetes and type 2 diabetes) and prediabetes.

Some researchers suggested that people who are living under prolonged periods of stress due to chronic illness or stress are associated with a higher risk of high blood sugar.

Others suggested that an unhealthy diet such as high in saturated and trans fat, red meat, and processed food, and lack of physical exercise have many folds increased the risk for the onset of hyperglycemia.

In fact, shift workers accompanied by an unhealthy lifestyle are the joint associated with the risk of type 2 diabetes.

Dr. Shan Z, in the concerns of the rotating night shift work and lifestyle factors in the risk of diabetes, used the data of Nurses' Health Study (1988-2012) and Nurses' Health Study II (1991-2013) and compared to the 143 410 women without type 2 diabetes, cardiovascular disease, or cancer at baseline, said, " The multivariable-adjusted hazard ratios for type 2 diabetes were 1.31 (95% confidence interval 1.19 to 1.44) per five-year increment of a duration of rotating night shift work and 2.30 per unhealthy lifestyle factor (ever smoking, low diet quality, low physical activity, and overweight or obesity)".

"For the joint association of per five-year increment rotating night shift work and per unhealthy lifestyle factor with type 2 diabetes, the hazard ratio was 2.83 (2.15 to 3.73) with a significant additive interaction (P for interaction <0.001)".


How severe is the diabetes risk in nurses in the rotating shift accompanied by an unhealthy diet? According to the team, during 22-24 years of follow-up, 10 915 cases of incident type 2 diabetes occurred.

The risk of type 2 diabetes is even higher if each individual factor is also included.


These results clearly suggested the onset of diabetes is not caused by a single factor but is associated with a group set of risk factors.


Luckily, most people with some of the above risk factors do not develop hyperglycemia or type 2 diabetes.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On finding a natural ingredient and whole food for the treatment of diabetes and diabetes complications, researchers examine the action of ginger in the diabetic population.

Selected mice fed by either a high-fat diet or a standard diet for a period of 17 weeks were given phloretin isolated from apples and [6]-gingerol isolated from ginger supplemented at two different doses.

Application of phloretin and [6]-gingerol inhibited the formation of AGEs by suppressing the receptor for advanced glycation end products (RAGE).

Where Advanced glycation end products are proteins or lipids that become glycated as a result of exposure to sugars. The products can substantially worsen certain chronic diseases such as diabetes.


Phloretin or [6]-gingerol supplementation significantly reduced plasma glucose, alanine aminotransferase, aspartate aminotransferase, AGEs, and insulin levels and enhanced GSH/GSSG ratio.

These results suggested that phloretin or [6]-gingerol supplementation not only inhibited the oxidative stress that causes abnormally high blood glucose but also improved insulin resistance against the onset of diabetes complications in mice fed with a high-fat diet.

Futhermore, the assessment of the effect of ginger consumption on glycemic status, lipid profile, and some inflammatory markers in patients with type 2 diabetes mellitus with the consumption of 1600 mg ginger versus 1600 mg wheat flour placebo daily for 12 weeks, also found that ginger reduced fasting plasma glucose, HbA1C, insulin, HOMA, triglyceride, total cholesterol, CRP and PGE₂ significantly compared with the placebo group (p < 0.05).

Ginger improved fasting glucose and parameters associated with the onset of insulin resistance without inducing any side effects.

Dr. Arablou T after taking into account co and confounders said, "Ginger improved insulin sensitivity and some fractions of lipid profile, and reduced CRP and PGE₂ in type 2 diabetic patients. Therefore ginger can be considered an effective treatment for the prevention of diabetes complications".

Taken altogether, ginger may be considered a functional food for the prevention and treatment of diabetes and diabetes complications induced by abnormally high blood glucose.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway by Sampath C1, Rashid MR1, Sang S2, Ahmedna M. (PubMed)
(2) The effect of ginger consumption on glycemic status, lipid profile, and some inflammatory markers in patients with type 2 diabetes mellitus by Arablou T1, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M. (PubMed)
(3) Zerumbone, a Phytochemical of Subtropical Ginger, Protects against Hyperglycemia-Induced Retinal Damage in Experimental Diabetic Rats by Tzeng TF1, Liou SS2, Tzeng YC3, Liu IM. (PubMed).
(4) Rotating night shift work and adherence to an unhealthy lifestyle in predicting the risk of type 2 diabetes: results from two large US cohorts of female nurses by Shan Z1,2, Li Y2, Zong G2, Guo Y3,4, Li J2,3, Manson JE3,5, Hu FB2,3,6, Willett WC2,3,6, Schernhammer ES3,6,7, Bhupathiraju SN2, (PubMed)

3,3'-#Diindolylmethane Exerts Cytotoxic Against #LiverCancer Cells, Researchers Say

Scientists may have found a bioactive ingredient for the treatment of liver cancer with no side effects, according to studies.

The liver is the largest internal organs in the human body which plays a critical role for maintaining the integrity of cells wall, production of vitamin D and steroid hormone and aiding the digestive system in absorption of nutrients, through the production of cholesterol.

Additionally, the liver also filters out waste from the blood coming from the digestive system before passing them to the other parts of the body.

Liver cancer is a medical condition caused by irregular cell growth in the tissues of the liver.

Most cases of liver cancer start in the cells on the surface of the inner lining of the liver tissues before penetrating into deeper layers of the liver.

At the early stage due to the small size of the tumor and lack of nerve tissues, most patients are asymptomatic.

However, at the advanced stage, cancer cells can travel a distance away from the liver to infect other healthy tissues and organs, leading to secondary metastasis.

Patients at this stage may experience the general symptoms of cancers such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue accompanied by the symptoms of persistent upper abdominal pain, abdominal swelling, jaundice, and chalky stools.

If you have some of the aforementioned symptoms, please make sure you check with your doctor to rule out the possibility of liver cancer.

Out of many risk factors associated with the onset of liver cancer, some researchers suggested that people who carry hepatitis viral may have a substantially higher risk of the disease.

Dr. Marc Ringehan, the lead researcher said, "Hepatitis B and C viruses are a global health problem causing acute and chronic infections that can lead to liver cirrhosis and hepatocellular carcinoma (HCC). These infections are the leading cause of HCC worldwide and are associated with significant mortality, accounting for more than 1.3 million deaths per year".

And, "The majority of viral-associated HCC cases develop in subjects with liver cirrhosis; however, hepatitis B virus infection can promote HCC development without prior end-stage liver disease".


Scientists in seeking potential and bioactive compounds for the treatment of liver cancer examined 3'3-Diindolylmethane (DIM, the major product of the acid-catalyzed oligomerization of indole-3-carbinol anti-liver cancer properties.

In two HCC cell lines SMMC-7721 and MHCC-97H, injection of DIM inhibited the proliferation, migration, and invasion of cancer cells.


In nude mice, DIM significantly decreased the volumes of SMMC-7721 orthotopic liver tumors and suppressed lung metastasis.

Furthermore, DIM decreased the level of phospho-FAK (Tyr397) which is found elevated in both vitro and in vivo.


The DIM anti-cancer cells efficacy on proliferation, migration, and invasion is probably due to the inhibition of the expression of matrixes (MMP2-9) associated with the promotion of cancer cell growth and invasion.

Dr. Li WX, the lead scientist wrote, "These results demonstrated that DIM blocks HCC cell metastasis by suppressing tumor cell migration and invasion".

Moreover, in order to reveal more information about DIM anti-liver cancer activity, researchers investigated whether diindolylmethane effect HA59T cells.

At concentrations of 10-75 μM, diindolylmethane killed cells in a concentration-dependent manner, particularly, in diindolylmethane (25-50 μM) induced apoptosis in a concentration-dependent manner.
The cytotoxic effect of diindolylmethane against the tested liver cancer cell line was not reversed by chelating cytosolic Ca(2+).

Where Calcium (Ca2+) ions are important for cellular signaling. Its flow plays an essential role in regulating several secondary messenger systems in neural adaptation for the visual, auditory, and olfactory systems.

The results suggested that DIM inhibited the onset and progression of liver cancer through a number of mechanisms, including proteins involved in anti-cell proliferation and migration, and promotion of apoptosis.

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of liver cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3'3-Diindolylmethane inhibits migration, invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling by Li WX1, Chen LP2, Sun MY1, Li JT1, Liu HZ1, Zhu W. (PubMed)
(2) Effect of diindolylmethane on Ca(2+) movement and viability in HA59T human hepatoma cells by Cheng JS1, Shu SS, Kuo CC, Chou CT, Tsai WL, Fang YC, Kuo LN, Yeh JH, Chen WC, Chien JM, Lu T, Pan CC, Cheng HH, Chai KL, Jan CR. (PubMed)(3) Viral hepatitis and liver cancer by Marc Ringehan,1,2,3 Jane A. McKeating,4,5 and Ulrike Protzer. (PMC)

#Herbal #Artichoke #Extract Inhibits All Parameters Associated with #Diabetes in Vivos, Researchers Suggest

Kyle J. Norton

Scientists may have found a natural ingredient for the treatment of metabolic syndrome with no side effects, according to studies.

A metabolic syndrome is a group of syndromes or diseases associated with an increased risk of cardiovascular disease and types 2 diabetes, including high blood pressure, sugar, cholesterol and triglyceride levels, and excess body fat around the waist.

If you have 3 of the above syndrome you are considered to have metabolic syndrome.

According to statistics, metabolic syndrome is a growing prevalence of chronic conditions, accounting for 17% of all health care costs and directly contributing to 43% of all deaths in Canada.

In other words, 1 in 5 people in Canada has metabolic syndrome, affecting 19.1% of all Canadian adults.

There are certain risk factors associated with the onset of metabolic syndrome besides the five mentioned above including age, family history of metabolic syndrome, physical activity, and women diagnosed with polycystic ovary syndrome.

Untreated metabolic syndrome epidemiologically may induce complications of chronic illness such as atherosclerosis, nonalcoholic fatty liver disease, and kidney disease.

Some researchers suggested that metabolic syndrome and widespread obesity in the US may be correlated as they share a hallmark of insulin resistance.

Dr. Keller KB in the differentiation of the metabolic syndrome in obese wrote, "Westernization of diets has been part of the problem. Fruits, vegetables, and whole grains are being replaced by readily accessible foods high in saturated fat, sugar, and refined carbohydrates".

And, "The metabolic syndrome associated with abdominal obesity, which includes insulin resistance, dyslipidemia, and elevated CRP levels, identifies subjects who have an increase in cardiovascular morbidity and mortality. Twenty to 25% of the adult population in the United States have the metabolic syndrome, and in some older groups this prevalence approaches 50%".

The results strongly suggested that both metabolic syndrome and obesity in the US population are attributed to the Western diet pattern.

In other words, by changing to a healthy diet such as a traditional diet, the risk of obesity and metabolic syndrome can be decreased substantially.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Scientists on finding a natural ingredient for the treatment of metabolic syndrome examined the long-term supplementation with dietary luteolin (LU)-enriched artichoke leaf (AR) in high-fat diet (HFD)-induced obesity and its complications in C57BL/6N mice.

Selected mice were fed a normal diet, an HFD, or an HFD plus AR or LU for 16 weeks.

In the HFD-fed mice, the application of AR decreased adiposity and dyslipidemia by decreasing lipogenesis.

Moreover, AR +LU prevented insulin sensitivity by decreasing the level of plasma gastric inhibitory polypeptide and activity of hepatic glucogenic enzymes and the proteins associated with liver inflammation,

Additional analysis of the effect of AR and LU suggested, although the anti-metabolic syndrome effects of AR and LU were similar, the anti-adiposity and anti-dyslipidemic effects of AR were more pronounced.

The findings strongly support the use of artichokes for the treatment of metabolic syndrome.

In order to know more information about artichoke anti-metabolic syndrome activity, researchers evaluated the protective effect of the ethanol leaves extract of C. scolymus in alloxan-induced stress oxidant, hepatic-kidney dysfunction and histological changes in liver, kidney, and pancreas of different experimental groups of rats.

A total of 40 male Wistar rats included in the study were induced to diabetes with a single dose intraperitoneal injection (i.p.) of alloxan (150 mg/kg body weight (b.w.)), then the diabetic rats were orally and daily administrated ethanol extract from C. scolymus at two doses (200-400 mg/kg, b.w) or (12 mg/kg, b.w) with anti-diabetic reference drug, Acarbose for one month.

In vivo, injection of the ethanol extracts from the leaves of C. scolymus (200-400 mg/kg) decreased significantly, the α-amylase levels in the serum of diabetic rats associated with a significant reduction in blood glucose rate of 42,84% and 37,91% after 28 days of treatment.

The extracts also induced a significant lowering of plasma total cholesterol (T-Ch) by 18,11% and triglyceride (TG) by 60,47%, and low-density lipoproteins (LDL-C) by 37,77%, compared to diabetic rats.

Oxidative stress markers in the liver, kidney, and pancreas also were reduced by the injection of the extracts.

The findings suggested the anti-metabolic syndrome of artichoke was attributed to its anti-hyperglycemic properties, at least partly mediated by antioxidant and hypolipidemic effects

Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of metabolic syndrome, pending the confirmation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.




Sources
(1) Luteolin-Enriched Artichoke Leaf Extract Alleviates the Metabolic Syndrome in Mice with High-Fat Diet-Induced Obesity by Kwon EY1,2, Kim SY3, Choi MS. (PubMed)
(2) Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats by Ben Salem M1, Ben Abdallah Kolsi R2, Dhouibi R1, Ksouda K1, Charfi S3, Yaich M4, Hammami S1, Sahnoun Z1, Zeghal KM1, Jamoussi K4, Affes H. (PubMed)
(3) Obesity and the metabolic syndrome by Keller KB1, Lemberg L. (PubMed)