Long-term Intake of #RawHoney Ameliorates Allergy Symptoms by Regularly Exposing to Pollens, According to Studies

Kyle J. Norton

Scientists may have found a natural alternative for the treatment of allergies, according to studies.
Allergies are a faulty reaction of the immune system responses against harmful substances that enter the body.

Symptoms and diseases associated with allergy include sinus swelling, seasonal and returning allergies, hay fever, and nasal allergies.

Believe it or not, Penicillin, an antibiotic medicine is the most common allergy trigger in drug allergies. 10 percent of people are allergic after using the medicine.

According to the statistics, in the US, approximately, more than 50 million Americans have experienced various types of allergies each year and 15 million Americans have food allergies, including 5.9 million children under age 18.

In other words, 1 in 13 children suffers from a food allergy. About 30 percent of children with food allergies are allergic to more than one food.


The findings strongly suggested that foods are the most common and major cause of allergic onset.

Dr. Ruchi S. Gupta and colleagues in the allergic team in examining the food allergies in children wrote, "Overall, estimated current FA prevalence was 7.6%,.The most prevalent allergens were peanut (2.2%), milk (1.9%), shellfish (1.3%), and tree nut (1.2%)".

And, "Among food-allergic children, 42.3% reported ≥1 severe FA and 39.9% reported multiple FA. Furthermore, 19.0% reported ≥1 FA-related emergency department visit in the previous year, and 42.0% reported ≥ 1 lifetime FA-related emergency department visit, whereas 40.7% had a current epinephrine autoinjector prescription.

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one healthy sweet food for replacing the use of white sugar and artificial sweetener many people.

Researchers on finding a natural compound for the treatment of allergies examined the honey effects in the treatment of allergic rhinitis (AR).

The prospective randomized placebo-controlled study included 40 AR patients divided equally into a case group and a control group. All the subjects received a daily dose of 10 mg of loratadine for 4 weeks.

The case group then ingested 1 g/kg body weight of honey daily in separate doses for the 4-week period. The control group ingested the same dose of honey-flavored corn syrup as a placebo.

According to the AR symptoms scored at the start, week 4, and week 8 of the study, at week 4, both groups showed progressive improvement in the symptoms, however, at week 8, only the case group showed continuous improvement in the symptom score.

The ingested honey group showed a significant improvement in individual AR symptoms after week 8 and the efficacy in reducing the symptoms persisted for a month after the cessation of the honey treatment.

The results suggested that honey processed certain chemical compounds that were not found in the corn syrup for the treatment of AR.

Some researchers suggested that long-term intake of raw honey can help to ameliorate allergy symptoms by regularly exposing to pollen, similar to the allergy injection in desensitizing pollen-program.

If this result is true then only local honey can process the anti-AR symptoms compared to honey unlocalized pollen.

Taken altogether, honey may be considered a functional remedy for the prevention and treatment of AR symptoms, regardless of the type of honey, pending the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Ingestion of honey improves the symptoms of allergic rhinitis: evidence from a randomized placebo-controlled trial in the East coast of Peninsular Malaysia by Asha'ari ZA1, Ahmad MZ, Jihan WS, Che CM, Leman I. (PubMed)
(2) Will honey relieve my seasonal allergies? by Allergists
(3) The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States by Ruchi S. Gupta, Christopher M. Warren, Bridget M. Smith, Jesse A. Blumenstock, Jialing Jiang, Matthew M. Davis, Kari C. Nadeau. (APP News and Journals)

#BilberryExtract Inhibits Proliferation of and Induces Apoptosis in #BreastCancer cells in Vitros, Researchers Say

Kyle J. Norton

Bilberry may be the next potential therapeutic treatment for breast cancer with no side effects, according to studies.
Breast cancer is the chronic condition characterized by irregular cells growth in the breast tissue caused by the alternation of DNA.

The causes of breast cancer are unknown, As of today, researchers cannot explain why people with the same health conditions in the same family, are susceptible to the onset of breast cancer while others do not.

According to the statistics, 1 in 8 U.S. women, representing 12.4 % of all women will develop invasive breast cancer over the course of her lifetime.

Believe or not, In 2018, approximately 266,120 new cases of invasive breast cancer were diagnosed in women in the U.S.

The 5 years survival rate of breast cancer diagnosis at the early stage is 100%. Therefore, women at a higher risk of breast cancer should examine their breasts at least once a month for preventive measure.

Most cases of breast cancer begin in the cells on the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

Women with breast cancer may experience symptoms of lump, swelling of all or part of a breast, skin irritation or dimpling, breast or nipple pain, nipple retraction, redness, and scaliness.

If you experience some of the above symptoms, please make sure to check with your doctor as soon as possible to rule out the possibility of breast cancer.

In North America, some researchers suggested that obesity may have a strong impact on the risk of breast cancer onset.

Dr. Manuel Picon‐Ruiz, the lead scientist in the study of "Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention", wrote, "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages".

And, " the effects of obesity to increase local and circulating proinflammatory cytokines, promote tumor angiogenesis and stimulate the most malignant cancer stem cell population to drive cancer growth, invasion, and metastasis".

The results clearly suggested that if you are obese, your risk of breast cancer is increased substantially, compared to non-obese individuals.

Bilberry is a species of low-growing shrub in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

Researchers on finding a natural compound for the treatment of breast cancer examined the bilberry effect on the MCF7 human breast cancer cells.

Bilberry extract inhibited cell proliferation in a concentration-dependent fashion with a 50% inhibitory concentration of 0.3-0.4 mg/mL.

At this concentration, the natural compound also concerts the induction of apoptotic cell death of the cancer cells with no apparent effect on the microtubule that provides structure and shape to the cytoplasm of eukaryotic cells or actin cytoskeletons.

In other words, bilberry extract induced cancer cell apoptosis was not through cell cycle arrest at this concentration.

However, at the higher extract concentrations (0.5-0.9 mg/mL), the extract did cause an increase in the fraction of cells at the G(2)/M phase of the cell cycle.

Further differentiation of the cell death, bilberry extract at 0.3-0.4 mg/mL did not appreciably inhibit microtubule polymerization in vitro, but significant inhibition of polymerization (approximately 30%) did occur at higher extract concentrations (0.5-1 mg/mL).

Moreover, researchers found that the efficacy of bilberry against breast cancer cell was attributed not by the expression of anthocyanins but all phytochemicals in the extracts.

Dr. Nguyen V and colleagues wrote in the final report, " (Bilberry extract) inhibits proliferation of and induces apoptosis in breast cancer cells at its lowest effective concentrations via a mechanism that does not involve action on microtubules or on mitosis.

And, "At somewhat higher concentrations the extract modifies microtubule organization in cells and causes accumulation of cells at mitosis by a direct action on microtubules".

Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of breast cancer, pending the confirmation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Cytotoxic effects of bilberry extract on MCF7-GFP-tubulin breast cancer cells by Nguyen V1, Tang J, Oroudjev E, Lee CJ, Marasigan C, Wilson L, Ayoub G. (PubMed)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., Cynthia Morata‐Tarifa, Ph.D., Janeiro J. Valle‐Goffin, MD, Eitan R. Friedman, MD, and Joyce M. Slingerland, MD, Ph.D. (PMC)

#VegetableConsumption Inhibits Markers of Immune Function and Oxidativestress Against the Risk of CVD, According to Studies

Kyle J. Norton

Artichoke may be used as a natural and herbal remedy for the treatment of heart disease with no side effects, according to studies.
Heart disease is a class of diseases associated with interruption of blood flow in the blood vessel or damage of the heart tissue, including coronary artery diseases (CAD) such as angina and myocardial infarction.

According to the statistics, heart disease is a leading cause of death in the US. Approximately 2000 people in the general population die of heart disease every day.

Coronary heart disease (CHD) is the most common type of heart disease, that kills over 370,000 people annually.

The most common risk factors associated with heart disease are aging, family history with heart disease, metabolic syndrome, high blood pressure and cholesterol, obesity, smoking, and stress epidemiologically.

However, most people with some of the above risk factors have never developed heart disease. Symptoms of heart disease completely depend on the infected location.

Some researchers suggested that by making a change in lifestyle accompanied by moderate physical activity such as walking, the risk of heart disease can be prevented.


The American College of Cardiology wrote in the article of Heart Disease: Lifestyle Changes to Lower Risk. "Start slowly, and go at a pace you can manage. Try to do at least 2½ hours of moderate exercise a week. One way to do this is to be active 30 minutes a day, at least 5 days a week".


"Healthy eating starts with learning new ways to eat, such as adding more fresh fruits, vegetables, and whole grains and cutting back on foods that have a lot of saturated fat, sodium, and sugar"

"Getting active and eating a healthy diet can help you lose extra weight and quit smoking"

Finally, the article continued, "Even though you are taking medicine, it is always important to make lifestyle changes that keep your heart and your body healthy".

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae, native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.

Finding a natural ingredient for the treatment of cardiovascular diseases has been a dream of many scientists. Researchers at the joint study led by the IRCCS San Raffaele Pisana examined the effects of vegetables, including artichoke on CVD.

The joint study included a total of 38 subjects at risk of CVD. After, a week of the run-in period, participants were randomly assigned to one of the following 4-week interventions: low vegetable consumption (800 g of vegetables/week) or high vegetable consumption (4200 g of vegetables/week).


According to the assays that record immunological, and antioxidant markers, leukocyte and lymphocyte expression of the gut-homing β7 integrin, there were no significant changes detected in clinical, immunological, and antioxidant markers in biological samples, except for an increase in white blood cell count for the low vegetable consumption group.

Immune system's innate and adaptive immune responses play an essential role in the development and progression of cardiovascular diseases by inhibiting the pro-inflammatory expression.

Vegetable consumption group exerts a CVD protective effect in modulating markers of immune function and antioxidant status in patients with CVD. In healthy individuals, intake of vegetables does not induce a change of both antioxidant and inflammatory markers associated with immune function, particularly in nonsmoking men.

These results strongly suggested that vegetables modulate the function of the immune system according to the needs of the body.

In other to reveal more information about artichoke anti-CVD activity, Dr. Rondanelli M and colleagues at the University of Pavia investigated the artichoke extracts on cardiovascular disease in both animals and men.

Injection of artichoke not only reduced the levels of cholesterol in the bloodstream through its hypolipidemic activity but also inhibited the expression of high blood glucose and free radicals through the antioxidant and hypoglycemic activity.


The results indicated artichoke reduced the risk and progression of cardiovascular disease by improving the production of antioxidant enzymes against oxidative stress in the initiation of low-grade inflammation, a hallmark of CVD.

Futhermore, artichoke also decreases the levels of blood cholesterol and glucose, the cluster conditions associated with the risk of CVD, epidemiologically.

Taken altogether, artichoke which processes anti cardiovascular diseases activity through several mechanisms may be considered a functional remedy for the prevention and treatment of cardiovascular diseases, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such asthe international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effects of High Consumption of Vegetables on Clinical, Immunological, and Antioxidant Markers in Subjects at Risk of Cardiovascular Diseases by Peluso I1, Raguzzini A1, Catasta G1, Cammisotto V1, Perrone A1, Tomino C2, Toti E1, Serafini M. (Hindawi)
(2) Health-promoting properties of artichoke in preventing cardiovascular disease by its lipidic and glycemic-reducing action by Rondanelli M1, Monteferrario F, Perna S, Faliva MA, Opizzi A. (PubMed)
(3) Heart Disease: Lifestyle Changes to Lower Risk by The American College of Cardiology

#Herbal #Calendula Exhibits Anti-inflammatory Activity Against the Progression of Edema, Scientists Suggest

Kyle J. Norton

Herbal Calendula may have a potential effect in reducing the risk and treatment of edema, some scientists suggested.
Edema is a condition characterized by an abnormal accumulation of fluid in certain tissues within the body due to injury or inflammation.

In most cases, edema occurs under the surfaces of the skin in the leg and ankle. However, fluids can also be accumulated in the lungs (pulmonary edema).

Without the assistance of diagnosis, researchers can not pinpoint the exact causes of edema.

There is a number of risk factors associated with the onset of the swellings, such as low levels of albumin that keeps the blood in the vessels, allergic reaction, and blood clots. Some medical conditions such as congestive heart failure, kidney diseases, and long-term intake medicine such as NSAIDs and calcium channel blockers also increased the risk of edema.

Some researchers suggested that under normal conditions, medicine that removes excess fluid and reduces the intake of salt can be effective. However, if the condition of edema is caused by the underlying disease, separate medicine treatment may be required.

If you are experiencing symptoms of heavy leg and ankle and shortness of breath, please check with your doctor to rule out the edema possibility.

Calendula is also known as pot marigold, annual or perennial herbaceous plant of about 12–20 species of the genus Calendula, belonging to the family Asteraceae, native to Southern Europe.

The herb has been used in herbal medicine for spasmolytic, spasmogenic, and inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.


In the study to examine the anti-inflammatory effect of Calendula officinalis flower extract against paw edema, researchers at the Amala Cancer Research Centre launched an investigation into the paw edema of animals induced by carrageenan and dextran.

Oral injections of 250 and 500 mg/kg body weight of Calendula extract exerted a significant inhibition (50.6 and 65.9% respectively) in paw edema of animals by 41.9% in the carrageenan group and 42.4% in the dextran group, respectively through the anti-inflammatory activity.

In chronic inflammatory models induced by injection of formalin, administration of 250 and 500 mg/kg body weight of Calendula extract produced an inhibition of 32.9 and 62.3% respectively compared to controls.

Further examination also found that proinflammatory cytokines activated by macrophages of the immune system in the response to infection are also reduced significantly.

Other proinflammatory proteins such as IL- 1beta, IL-6, TNF-alpha, and IFN-gamma and acute phase protein, C- reactive protein (CRP) in edema mice produced by LPS injection were inhibited significantly by the extracts in different doses.

These results suggested that herbal Calendula inhibits edema caused by inflammation through its anti-inflammatory expression.

Additionally, in the study to reaffirm the efficacy of Calendula anti-inflammation against the progression of edema, researchers at the niversità di Trento conducted a differentiation on the anti-inflammatory chemical constituents of the herb.

13 out of 15 terpenoids from Calendula were found to process topical anti-inflammatory activities with respect to the inhibition of croton oil-induced ear edema in the mouse.

Three derivatives of Rings A, D, and E of faradiol, the C(16) benzyl ether 15, the C(30) aldehyde 24, and the C(30) primary alcohol 25 isolated from the herb also showed a significantly improved anti-inflammatory potency.

Taken together, herbal Calendula with abundant anti-inflammatory bioactive compounds may have a potential effect in the prevention and treatment of inflammatory edema.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Phytochemical Constituents and PharmacologicalActivities of Calendula officinalis Linn (Asteraceae): A Review by BP Muley, SS Khadabadi and NB Banarase (Tropical Journal of Pharmaceutical Research)
(2)Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action by Preethi KC, Kuttan G, Kuttan R.(PubMed)
(3) Improved anti-inflammatory activity of three new terpenoids derived, by systematic chemical modifications, from the abundant triterpenes of the flowery plant Calendula officinalis by Neukirch H, D'Ambrosio M, Sosa S, Altinier G, Della Loggia R, Guerriero A.(PubMed)

#Betanin Inhibits the Risk of #Colitis (UC) and #Crohn's disease (CD) by Preventing Oxidativestress Induced Intestinal Mucosal Inflammation, Researchers Say

Kyle J. Norton

Colitis is a general term associated with the inflammation of the inner lining of the colon.
The disease can be caused by infection, inflammatory bowel disease (Crohn's disease (CD), ulcerative colitis(CD)), ischemic colitis, allergic reactions, and microscopic colitis.

Most cases of colitis are involved in the damage of the intestinal mucosal barrier, particularly to those of ulcerative colitis.

Epidemiologically, damage and a reduction of gut bacteria by dietary chemicals, such as antibiotics of the protective mucus layer and the underlying tissue by the poorly inactivated digestive proteases have been found to induce both UC and CD.

The intestinal mucosal barrier is the outermost layer of the lining of the intestines which plays an essential role to ensure the adequate containment of undesirable luminal contents within the intestine while preserving the ability to absorb nutrients.

Additionally, the intestinal mucosal barrier also processes various immunological mediators, including cytokines and chemokines stimulated by gut microbiota and host immune responses, thus maintaining a well-balanced relationship between gut microbes and the host immune system.

In other words, the intestinal mucosal barrier protects the colonic integrity by interacting with the gut microbiota and the immune response to prevent the inflammation of the colon that causes the onset of colitis.

Some researchers suggested disruption of the inaction of the immune system and gut microbiota caused by dysfunction of the intestinal mucosal barrier due to trauma, infection, neoplasia, and inflammation has been found to induce colitis in the experimental models.

Dr. K R Gardiner, the lead scientist in the examination of the mucosal barrier dysfunction as a feature of colitis irrespective of etiology or species wrote, "There were significantly increased systemic endotoxin concentrations in rats with acetic acid (7.5 (1.7-119.5) pg/ml), ethanol (13.7 (0-111.2) pg/ml), and hapten-induced (14.4 (5-31.1) pg/ml) colitis compared with saline controls (3.3 (0-13.7) pg/ml).

And, "There were significant correlations between the systemic endotoxin concentration and both the severity of colitis and of illness in acetic acid-induced colitis".


The finding strongly suggested that mucosal barrier dysfunction induces a significant increase in the chemical toxins involved in colitis development.

Betanin phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, are found abundantly in beets, chard, etc.

In the finding of a natural and bioactive compound with autophagy and anti-inflammation properties against the onset of colitis, researchers examined the effects of phytochemical isolated from beetroot in an animal model.

The study included mice treated with intrarectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) (3.5 mg·20 g-1 ) induced colitis 2 or 4 days after treatment. Among the treated mice, some mice received trehalose (3% in drinking water 3 weeks before TNBS administration) or a daily administration of rapamycin (1.25 mg·kg-, i.p.), betanin (1 g·kg-, i.p.) or betanin + 3-methyladenine (3MA) (10 mg·kg-, i.p.).

TNBS-treated mice alone showed impaired autophagy associated with body weight loss and intestinal damage.

Administration of trehalose, rapamycin, or betanin not only prevented the impaired autophagic flux induced by TNBS but also reduced the expression of pro-inflammatory cytokines in the intestinal mucosa.

The anti-inflammatory activity of trehalose, rapamycin, or betanin was also observed by a decrease in M1 macrophage markers.

The results suggested that betanin processes pharmacological stimulation of mucosal autophagy in reduced intestinal inflammation and improved murine colitis.


Furthermore, in patients with ulcerative colitis (UC) and Crohn's disease (CD). betanin also protected the colitic cells against oxidative DNA damage and induced apoptosis in neutrophils isolated from blood, through its antioxidant and anti-inflammatory properties.

The finding suggested that in normal intestinal cells, betanin protects the cell's integrity against intestinal mucosal inflammation in the formation of colitis by inducing autophagy and anti-inflammatory effects.


Taken altogether, betanin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of colitis, pending the confirmation of the larger sample size and multicenter human study.

Intake of betanin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary ToProfessional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Stimulation of autophagy prevents intestinal mucosal inflammation and ameliorates murine colitis by Macias-Ceja DC1, Cosín-Roger J2, Ortiz-Masiá D2,3, Salvador P2, Hernández C1,2, Esplugues JV1,2, Calatayud S2, Barrachina MD. (PubMed)
(2) DNA damage and apoptosis in blood neutrophils of inflammatory bowel disease patients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W. (PubMed)
(3) Colitis and colonic mucosal barrier dysfunction by K R Gardiner, N H Anderson, B J Rowlands, and A Barbul. (PMC)

#Tomatoes Show a Strong Effect Against Brain Cholesterol in Facilitating Neuron Damage, Researchers Say

Kyle J. Norton

Hypercholesterolemia is a condition of high blood cholesterol. A condition is a form of hyperlipidemia or high blood lipids.
The cause of hypercholesterolemia is a result of overexpression of low-density lipoprotein with reduced levels of high-density lipoprotein in the blood.

Believe it or not, cholesterol produced by the liver or from outside sources is essential for the building of strong cell membranes, the production of steroid hormones and vitamin D.

However, overexpression of blood cholesterol-induced hypercholesterolemia has been found to exhibit the risk of cardiovascular disease and diabetes.

Compared to hypercholesterolemia, the healthy levels of LDL/HDL are any number that is less than 4.

There is no single cause of hypercholesterolemia. Epidemiologically, diet, obesity, genetic preposition, and medical conditions such as diseases such as type 2 diabetes and an underactive thyroid are some of the prevalent factors associated with the risk of the condition.

According to the statistics, over 34 million American adults are living with elevated blood cholesterol levels (higher than 240 mg/dL). ...

The most common inherited form of high blood cholesterol is called familial hypercholesterolemia found in 1/500 people.

By adopting a healthy lifestyle and moderate exercise, you may do just fine without medication.

Tomato is red, edible fruit, genus Solanum, and belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to find a natural ingredient or whole food for the treatment of hypercholesterolemia, researchers compared the effect of dried tomato, grape, and apple pomace (5% in diet) on the cholesterol levels in serum in an animal model

The study included selected male Wistar rats fed a cholesterol diet (0.3%) shortly after weaning followed by administration of individual fruits containing 47.2, 67.0, and 46.2 g of total dietary fiber per 100 g of dry matter for tomato, grape, and apple pomace, respectively.

Compared to apples pomace reduced the liver cholesterol by 11% tomato showed a better-reduced cholesterol level in the liver by 15%

Tomatoes and other tested pomace species reduced cholesterol content in the heart by 18-21%.

Only tomatoes exerted a significant effect on the levels of triacylglycerol content in the heart compared to other tested pomaces.


All products strongly reduced (up to half of the original value) the activity of enzymes HMG-CoA reductase associated with the production of cholesterol in the liver and increased the fractional catabolic rate of plasma cholesterol by 60-120%.


In rats fed with hypercholesterolemic feed and treated with lycopene orally by gavage at the dose of 5, 25, 45, 65, 85, and 105, 125 mg/kg/bw-1/d-1, researchers found that injection of all doses of lycopene exerted a statistical significance in reducing the levels of cholesterol observed by inverse U shape at the 4 weeks of the experiment.

Furthermore, serum lycopene concentration was negatively correlated with the levels of serum TC, and LDL-C, particularly in the cerebral LDL-C.

In other words, serum lycopene found in the tested model showed a strong effect against brain cholesterol in facilitating neuron damage.

Dr. Wang W, the lead scientist said, "These results suggested an inverse U-shape relation between dose and serum concentration of lycopene, and intermediate doses were most effective to protect cerebral vessels and neurons from being damaged by hyperlipidemia".


Taken altogether, tomatoes processed with high amounts of lycopene may be considered supplements for the prevention and treatment of hypercholesterolemia, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) The effect of dried tomato, grape, and apple pomace on the cholesterol metabolism and antioxidative enzymatic system in rats with hypercholesterolemia by Bobek P1, Ozdín L, Hromadová M. (PubMed)
(2) The dose-response effect of lycopene on a cerebral vessel and neuron impairment induced by hyperlipidemia by Wang W, Yang W, Shen Z, Wen S, Hu M. (PubMed)

#Herbal #Artichoke Extract Inhibits the Protein Involved in Cell Survival and Pro-Proliferative Activity in Cancer, According to Studies

Kyle J. Norton

Artichoke may be the generation of whole food medicine for the treatment of colorectal cancer caused by oxidative stress, some scientists suggested.
Colorectal cancer is a chronic disease associated with a malignant tumor in the colon or rectum.

Most cases of colorectal cancer start in the cells on the surface of the inner lining tissue of the colon or rectum.

Due to the slow growth in nature, most people with colorectal cancer do not experience any symptoms until the advanced stage.

Besides the most common symptoms of cancer such as unintended weight loss and loss of appetite, late stage of colon cancer can induce symptoms of change of bowel movement, bloody stool, and persistent abdominal discomforts, such as cramps, gas, or pain.

If you experience some of the above symptoms, please contact your doctor to rule out the possibility of colorectal cancer.

In this stage, cancer cells can also travel a distance away to infect other healthy tissue and organs, leading to a second metastasis.

In the US, colorectal cancer is the third leading cause of cancer death. According to the statistic provided by the American Cancer Society, approximately, there were 97,220 new cases of colon cancer. 43,030 new cases of rectal cancer. in 2018.

The 5-year relative survival rate of localized colorectal cancer is about 92%. Therefore, people who are at a higher risk of colorectal cancer should have their bowel checked every year for preventive measures.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas, bloating, etc.

Researchers on finding potential and natural compounds for the treatment of colorectal cancer examined the artichoke anticancer activity against DLD1 colorectal cancer cells.
The study included the extracts from wild and cultivated Cynara species obtained from their vegetative parts and receptacles and was applied with five different doses from 0.1-1 mg/ml in three time periods (24, 48, and 72 hours) to the tested model.


At IC50 doses, all extracts demonstrated a significant cell apoptotic effect by stimulating the expression of a protein associated with tumor suppression.

Futhermore, at the same IC, artichoke extracts induced cancer cell death by activating the gene expression in regulating cell death.

Moreover, the injection of artichoke extracts inhibited the protein involved in cell survival and pro-proliferative activity.

In other words, artichoke extracts increased the pro-apoptotic (BAX) gene expression and a cell cycle inhibitor (p21) against the tumor.

In the depth analysis, researchers also found that DNA fragmentation, the indication of cell death was also found in the tested DLD1 colorectal cancer cells.

Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of colorectal cancer, pending the confirmation of a larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) In vitro investigation of cytotoxic and apoptotic effects of Cynara L. species in colorectal cancer cells by Simsek EN1, Uysal T. (PubMed)