Kyle J. Norton
Oxidative stress is a condition characterized by either overexpression of free radicals comparable to the levels of antioxidant enzymes or depleted levels of antioxidants comparable to levels of free radicals in the body.
In other words, oxidative stress is a result of the unbalance in the ratio of the levels of free radicals and antioxidants.
Free radicals are oxidants produced either from the body's essential metabolism or external sources such as exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals.
Oxidative stress has been found to alter lipid, protein, and cell DNA, leading to atherosclerosis, cancer, diabetes, rheumatoid arthritis, ... and post-ischemic perfusion injury.
In lipids, free radicals damage the cell membranes affecting the cell's ability to transport oxygen, nutrients, or water to the cells.
In proteins, free radicals also attack the nucleic acid of the cell, affecting its function in the regulation of cell function, growth, and repair of the damaged tissues.
In cells, free radicals cause cell damage that has been found to initiate abnormal cell growth and cancers
Antioxidants are stable molecules that inhibit oxidation induced by free radicals.
In healthy individuals, antioxidant enzymes produced by the body are more than enough to inhibit the bombardment of free radicals. However, in people with health issues such as a weakened immune system, intake of dietary antioxidants may be necessary.
Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.
The liquid is considered one of the healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Researchers on finding a natural compound which processes the property in the inhibition of oxidative stress examined the Tualang honey (TH) antioxidants profile against oxidative stress of exercise.
The study included 20 female athletes (aged 21.3 [2.1] years; body weight [BW] 54.1 [5.7] kg) randomly assigned into two groups and consumed either 1.5 g/kg BW TH (high honey; HH; n = 10) or 0.75 g/kg BW TH (low honey; LH; n = 10).
Observation of the 3-h area under the curve (AUC), LH group compared with the HH group, showed a significant reduction of oxidative stress through the marker Malondialdehyde (MDA).
Compared to the LH groups, the MDA concentration significantly decreased (p < 0.05) from baseline to 2 h and significantly increased from 2 to 3 h in the HH group.
The reactive oxygen species production (ROS) was increased significantly from 0.5 to 3 h in the HH group, compared to the insignificant change in the LH group.
The findings strongly suggested a low dose of honey (LH) intake may have a comparable response in increasing antioxidant activity and suppressing oxidative stress in female athletes.
Dr. Ahmad NS, the lead scientist, emphasized, " The time-course effect of TH that provides optimal antioxidant activity and oxidative stress protection was between 1 and 2 h after its consumption".
In order to reveal more information about Tualang honey antioxidant activity, researchers investigated the Tualang Honey (TH) in the cerebral cortex of rats against KA-induced oxidative stress and neurodegeneration in an animal model of KA-induced excitotoxicity.
Male Sprague-Dawley rats selected for the study were randomly divided into five groups: Control, KA-treated group, TH + KA-treated group, aspirin (ASP; anti-inflammatory agent) + KA-treated group, and topiramate (TPM; antiepileptic agent) + KA-treated group.
The animals were also pretreated orally with drinking water, TH (1.0g/kg BW), ASP (7.5mg/kg BW), or TPM (40mg/kg BW), respectively, five times at 12 h intervals. KA (15mg/kg BW) was injected subcutaneously 30 min after the last treatment to all groups except the control group (normal saline).
Injection of KA displayed significantly more neuronal degeneration in the piriform cortex and heightened the predilection to seizures as compared with the control animals.
Although pretreatment with TH reduced the KA-induced neuronal degeneration in the piriform cortex, the honey failed to prevent the occurrence of KA-induced seizures.
However, TH pretreatment also inhibited the increased locomotor activity and hyperactivity caused by the KA.
Additionally, TH also reduced the levels of oxidative stress by stimulating the production of antioxidant enzymes produced by the host body.
Taken together, Tualang honey may be considered a functional remedy for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Dose-Response Effect of Tualang Honey on Postprandial Antioxidant Activity and Oxidative Stress in Female Athletes: A Pilot Study by Ahmad NS1, Abdul Aziz A2, Kong KW2, Hamid MSA3, Cheong JPG1, Hamzah SH1. (PubMed)
(2) Effect of Tualang honey against KA-induced oxidative stress and neurodegeneration in the cortex of rats by Mohd Sairazi NS1, K N S S2, Asari MA3, Mummedy S1, Muzaimi M4, Sulaiman SA5. (PubMed)
Sunday, 25 June 2023
#Cucurbitacins (CuB) Isolated from #Cucumber Exhibits Cytotoxic Activities Against Cancer Cells, Researchers Say
Kyle J. Norton
Antioxidants are atoms that inhibit oxidation.
Cytotoxicity is an action that kills cancer cells by inducing toxins to the cells.
Antioxidant activity is an action in which the stable atoms inhibit the expression of free radicals including antioxidants with free radical scavenging properties.
In other words, an antioxidant produced by the host or from a dietary source balances the levels of free radicals produced by the cellular metabolism and from outside of our body.
In a healthy individual, antioxidant enzymes produced by the body are good enough to counter the expression of free radicals. However, in people with a weakened immune system such as the elderly, intake of antioxidant supplements may be necessary.
Free radicals are unstable atoms with a single electron in the outer ring. Therefore, in order to remain stable. free radicals are ready to donate or intercept an electron from other atoms, leading to a chain of oxidative reactions that can not be stopped until all electrons are paired or inhibited by antioxidants.
Oxidative stress is an imbalanced ratio of free radicals and antioxidants in the body. It is caused by either overexpression of free radicals or depletion of antioxidants in the body.
Believe it or not. overexpression of free radicals for a long period of time or oxidative stress can cause cell and lipid damage, leading to the alteration of cell DNA.
Diseases associated with oxidative stress include atherosclerosis, cancer, diabetes, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation,... and stroke.
The risk of oxidative stress can be reduced by lifestyle change and moderate exercise.
Dr. Tameko Kihira, the lead scientist in the correlation of lifestyle and oxidative stress in patients with amyotrophic lateral sclerosis (ALS) wrote, "Recent lifestyle changes among the K residents, including a decrease in the Japanese pickle consumption, increase in fresh vegetable consumption and decrease in farm work, were evaluated in this study. Low consumption of Japanese pickles, high consumption of fresh vegetables, rare farm work, and low levels of 8-OHdG/creatinine were all associated with high scores in the cognitive function tests. Frequent farm work and consumption of Japanese pickles were associated with high contents of transition metals, such as Mn, Al, and V, in the scalp hair".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
On finding a natural and potential ingredient for the treatment of diseases associated with oxidative stress, researchers investigated the effect of Cucurbitacins (CuB), a major bioactive compound found in cucumber.
According to the antioxidative analysis, Cucurbitacins (CuB), not only showed significant scavenging free-radicals activity such as hydroxyl radical, superoxide anions, and singlet oxygen but also inhibited lipid peroxidation and oxidation.
In other words, CuB protected the cell's integrity by inhibiting the free radical expression before it can induce a chain of reaction to cause oxidative stress to the tissues and organs.
Furthermore, Cub also processes anti-inflammatory and analgesic properties by modulating the immune response against the production of proinflammatory cytokines in facilitating cellular and lipid damage and DNA alternation.
In the growth of four NSCLC cells (H1299, A549, HCC-827, and H661) Cucurbitacin B (CuB) inhibited cancer cell proliferation by altering the actin cytoskeletal assembly in the cell by cell cycle arrest and mitochondrial apoptosis.
Cucurbitacin B (CuB) inhibited the antioxidant activity produced by the cancer cells by significantly decreasing levels of protein thiols and GSH/GSSG ratio.
In other words, CuB causes cancer cell apoptosis by inducing cytotoxicity by disrupting the cancer cellular redox balance.
The results strongly suggested that on the one hand, CuB killed cancer cells through its cytotoxic by inducing overexpression of free radicals, and on the other hand CuB protected the healthy cells against cytotoxic damage through its antioxidant property.
Taken altogether, cucumber-processed abundantly bioactive compound CuB may be used for the treatment of diseases associated with oxidative stress and cancer, pending the confirmation of a larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Search for a novel antioxidant, anti-inflammatory/analgesic, or anti-proliferative drug: Cucurbitacins hold the ace by Adebowale Bernard Saba and Olayinka Oridupa. (Research Gate)
(2) Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets by Kausar H1, Munagala R, Bansal SS, Aqil F, Vadhanam MV, Gupta RC. (PubMed)
(3) Lifestyle Changes and Oxidative Stress in a High-incidence Area of Amyotrophic Lateral Sclerosis in the Southwestern Kii Peninsula, Japan by Tameko Kihira,1 Kazushi Okamoto,2 Iori Sakurai,1 Yuya Arakawa,1 Ikuro Wakayama,1Koichi Takamiya,3 Ryo Okumura,3 Yuhto Iinuma,3 Keiko Iwai,4 Yasumasa Kokubo,5 andSohei Yoshida. (PMC)
Antioxidants are atoms that inhibit oxidation.
Cytotoxicity is an action that kills cancer cells by inducing toxins to the cells.
Antioxidant activity is an action in which the stable atoms inhibit the expression of free radicals including antioxidants with free radical scavenging properties.
In other words, an antioxidant produced by the host or from a dietary source balances the levels of free radicals produced by the cellular metabolism and from outside of our body.
In a healthy individual, antioxidant enzymes produced by the body are good enough to counter the expression of free radicals. However, in people with a weakened immune system such as the elderly, intake of antioxidant supplements may be necessary.
Free radicals are unstable atoms with a single electron in the outer ring. Therefore, in order to remain stable. free radicals are ready to donate or intercept an electron from other atoms, leading to a chain of oxidative reactions that can not be stopped until all electrons are paired or inhibited by antioxidants.
Oxidative stress is an imbalanced ratio of free radicals and antioxidants in the body. It is caused by either overexpression of free radicals or depletion of antioxidants in the body.
Believe it or not. overexpression of free radicals for a long period of time or oxidative stress can cause cell and lipid damage, leading to the alteration of cell DNA.
Diseases associated with oxidative stress include atherosclerosis, cancer, diabetes, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation,... and stroke.
The risk of oxidative stress can be reduced by lifestyle change and moderate exercise.
Dr. Tameko Kihira, the lead scientist in the correlation of lifestyle and oxidative stress in patients with amyotrophic lateral sclerosis (ALS) wrote, "Recent lifestyle changes among the K residents, including a decrease in the Japanese pickle consumption, increase in fresh vegetable consumption and decrease in farm work, were evaluated in this study. Low consumption of Japanese pickles, high consumption of fresh vegetables, rare farm work, and low levels of 8-OHdG/creatinine were all associated with high scores in the cognitive function tests. Frequent farm work and consumption of Japanese pickles were associated with high contents of transition metals, such as Mn, Al, and V, in the scalp hair".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
On finding a natural and potential ingredient for the treatment of diseases associated with oxidative stress, researchers investigated the effect of Cucurbitacins (CuB), a major bioactive compound found in cucumber.
According to the antioxidative analysis, Cucurbitacins (CuB), not only showed significant scavenging free-radicals activity such as hydroxyl radical, superoxide anions, and singlet oxygen but also inhibited lipid peroxidation and oxidation.
In other words, CuB protected the cell's integrity by inhibiting the free radical expression before it can induce a chain of reaction to cause oxidative stress to the tissues and organs.
Furthermore, Cub also processes anti-inflammatory and analgesic properties by modulating the immune response against the production of proinflammatory cytokines in facilitating cellular and lipid damage and DNA alternation.
In the growth of four NSCLC cells (H1299, A549, HCC-827, and H661) Cucurbitacin B (CuB) inhibited cancer cell proliferation by altering the actin cytoskeletal assembly in the cell by cell cycle arrest and mitochondrial apoptosis.
Cucurbitacin B (CuB) inhibited the antioxidant activity produced by the cancer cells by significantly decreasing levels of protein thiols and GSH/GSSG ratio.
In other words, CuB causes cancer cell apoptosis by inducing cytotoxicity by disrupting the cancer cellular redox balance.
The results strongly suggested that on the one hand, CuB killed cancer cells through its cytotoxic by inducing overexpression of free radicals, and on the other hand CuB protected the healthy cells against cytotoxic damage through its antioxidant property.
Taken altogether, cucumber-processed abundantly bioactive compound CuB may be used for the treatment of diseases associated with oxidative stress and cancer, pending the confirmation of a larger sample size and multicenter human study.
Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Search for a novel antioxidant, anti-inflammatory/analgesic, or anti-proliferative drug: Cucurbitacins hold the ace by Adebowale Bernard Saba and Olayinka Oridupa. (Research Gate)
(2) Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets by Kausar H1, Munagala R, Bansal SS, Aqil F, Vadhanam MV, Gupta RC. (PubMed)
(3) Lifestyle Changes and Oxidative Stress in a High-incidence Area of Amyotrophic Lateral Sclerosis in the Southwestern Kii Peninsula, Japan by Tameko Kihira,1 Kazushi Okamoto,2 Iori Sakurai,1 Yuya Arakawa,1 Ikuro Wakayama,1Koichi Takamiya,3 Ryo Okumura,3 Yuhto Iinuma,3 Keiko Iwai,4 Yasumasa Kokubo,5 andSohei Yoshida. (PMC)
#Herbal #Arctostaphylos uva-ursi Inhibits Type 4 #Hypersensitivity and Augments the Anti-Allergic and Anti-Inflammatory Activity, Scientists Find
Kyle J. Norton
Scientists may have found a herbal medicine for the prevention and treatment of type 4 hypersensitivity with no side effects, according to studies.
Type 4 allergy or type 4 hypersensitivity is often called delayed-type hypersensitivity as the reaction takes several days to develop.
In other words, instead of happening right the way as that of other types, type 4 hypersensitivity typically develops at least 48 hours after exposure to an antigen.
The process that develops type 4 hypersensitivity involved the activation of the white blood cell cells in stimulating the release of cytokines and chemokines, and macrophages and cytotoxic CD8+ T cells associated with the body's adaptive immune response.
Compared to other types of allergy mediated by the antibody, type 4 allergy is a cell-mediated response.
Type 4 hypersensitivity can induce allergic contact dermatitis, occurred at the site where the antigen contacts the skin, then spread to other regions through contamination of the antigen.
Type 4 hypersensitivity is caused by atopic dermatitis, lung diseases associated with hypersensitivity, type 2 diabetes, and inflammation of the thyroid gland.
Treatment of type 4 hypersensitivity is totally depending on the severity of the disease. however, the most appropriate approach is to avoid the offending antigen.
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.
The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infections, kidney stones, pelvic pain, etc.
The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
In the concern of the widespread Type IV hypersensitivity caused by contact dermatitis, researchers at Kinki University examined the combined effect of arbutin isolated from the leaves of Arctostaphylos uva-ursi (L.) Spreng. (Bearberry leaf) and indomethacin on Type IV allergic reaction-induced immuno-inflammation, carrageenin-induced edema, and adjuvant-induced arthritis.
Injection of arbutin at a dose of 50 mg/kg 24 h after the application rapidly decreased the swelling of type IV allergic sheep-induced edema and adjuvant-induced arthritis by picryl chloride (PC-CD) compared to no reaction at the divided doses of 50 mg/kg.
Arbutin (p.o.) plus indomethacin (s.c.) exerted highly inhibitory effects on the swelling of PC-CD and sheep red cell delayed-type hypersensitivity (SRBC-DTH) compared to that of indomethacin alone.
Furthermore, arbutin (p.o.) and indomethacin (s.c.) in a given portion were simultaneously administered, the inhibitory effect was more potent than that of indomethacin alone in both carrageenin-induced edema and adjuvant-induced arthritis.
The results clearly suggested that arbutin may increase the inhibitory action of indomethacin on PC-CD, and SRBC-DTH against type 4 hypersensitivity.
Moreover, in the comparison of water extract (UW-ext) from the leaf of Arctostaphylos uva-ursi (L.) Spreng (Bearberry leaf) on the antiallergic and anti-inflammatory activities of dexamethasone ointment, researchers found one or 2% UW-ext ointment did not inhibit the ear swelling by picryl chloride-induced contact dermatitis (PC-CD) and carrageenin-induced paw edema.
However, combined with dexamethasone ointment (0.005 or 0.025%), UW-ext augmented the inhibitory effect of dexamethasone ointment (0.005 or 0.025%) on these allergic and inflammatory models with no side effects.
These findings showed that not all parts of herbal Arctostaphylos uva-ursi process anti-type 4 allergies, but combined with other therapy all parts augmented the significant anti-allergic and inflammatory activity with no side effects.
Additionally, the investigation of the antitype 4 allergies properties of the combined effect of 50% methanolic extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) and prednisolone also showed similar results as illustrated by the above 2 studies.
U-ext did not show an inhibitory effect on the swelling induced by PC-CD in divided doses of 100mg/kg immediately before and 16 h after the application of PC-CD, while it exhibited a significant therapeutic effect at a dose of 100 mg/kg or more once 24 h after the application.
Injection of the combination of U-ext (p.o.) and prednisolone (s.c.) simultaneously administered, exerted a greater inhibitory effect compared to that of prednisolone alone.
Researchers at the above studies wrote in the final report, "Bearberry leaf possesses a therapeutic effect against immuno-inflammation induced by PC-CD and also increases the inhibitory effect of prednisolone, and its active principle may be arbutin".
Taken altogether, herbal Herbal Arctostaphylos uva-ursi (Bearberry) may be considered a functional remedy for the prevention and combined with primary medicines for the treatment of type 4 hypersensitivity with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. V. Effect of water extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment].[Article in Japanese] by Matsuda H, Nakamura S, Tanaka T, Kubo M.(PubMed)
(2) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. III. Combined effect of arbutin and indomethacin on immuno-inflammation].[Article in Japanese] by Matsuda H, Tanaka T, Kubo M.(PubMed)
(3) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. I. Combined effect of 50% methanolic extract from Arctostaphylosuva-ursi (L.) Spreng. (bearberry leaf) and prednisolone on immuno-inflammation].[Article in Japanese] by Kubo M, Ito M, Nakata H, Matsuda H.(PubMed)
Scientists may have found a herbal medicine for the prevention and treatment of type 4 hypersensitivity with no side effects, according to studies.
Type 4 allergy or type 4 hypersensitivity is often called delayed-type hypersensitivity as the reaction takes several days to develop.
In other words, instead of happening right the way as that of other types, type 4 hypersensitivity typically develops at least 48 hours after exposure to an antigen.
The process that develops type 4 hypersensitivity involved the activation of the white blood cell cells in stimulating the release of cytokines and chemokines, and macrophages and cytotoxic CD8+ T cells associated with the body's adaptive immune response.
Compared to other types of allergy mediated by the antibody, type 4 allergy is a cell-mediated response.
Type 4 hypersensitivity can induce allergic contact dermatitis, occurred at the site where the antigen contacts the skin, then spread to other regions through contamination of the antigen.
Type 4 hypersensitivity is caused by atopic dermatitis, lung diseases associated with hypersensitivity, type 2 diabetes, and inflammation of the thyroid gland.
Treatment of type 4 hypersensitivity is totally depending on the severity of the disease. however, the most appropriate approach is to avoid the offending antigen.
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.
The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infections, kidney stones, pelvic pain, etc.
The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
In the concern of the widespread Type IV hypersensitivity caused by contact dermatitis, researchers at Kinki University examined the combined effect of arbutin isolated from the leaves of Arctostaphylos uva-ursi (L.) Spreng. (Bearberry leaf) and indomethacin on Type IV allergic reaction-induced immuno-inflammation, carrageenin-induced edema, and adjuvant-induced arthritis.
Injection of arbutin at a dose of 50 mg/kg 24 h after the application rapidly decreased the swelling of type IV allergic sheep-induced edema and adjuvant-induced arthritis by picryl chloride (PC-CD) compared to no reaction at the divided doses of 50 mg/kg.
Arbutin (p.o.) plus indomethacin (s.c.) exerted highly inhibitory effects on the swelling of PC-CD and sheep red cell delayed-type hypersensitivity (SRBC-DTH) compared to that of indomethacin alone.
Furthermore, arbutin (p.o.) and indomethacin (s.c.) in a given portion were simultaneously administered, the inhibitory effect was more potent than that of indomethacin alone in both carrageenin-induced edema and adjuvant-induced arthritis.
The results clearly suggested that arbutin may increase the inhibitory action of indomethacin on PC-CD, and SRBC-DTH against type 4 hypersensitivity.
Moreover, in the comparison of water extract (UW-ext) from the leaf of Arctostaphylos uva-ursi (L.) Spreng (Bearberry leaf) on the antiallergic and anti-inflammatory activities of dexamethasone ointment, researchers found one or 2% UW-ext ointment did not inhibit the ear swelling by picryl chloride-induced contact dermatitis (PC-CD) and carrageenin-induced paw edema.
However, combined with dexamethasone ointment (0.005 or 0.025%), UW-ext augmented the inhibitory effect of dexamethasone ointment (0.005 or 0.025%) on these allergic and inflammatory models with no side effects.
These findings showed that not all parts of herbal Arctostaphylos uva-ursi process anti-type 4 allergies, but combined with other therapy all parts augmented the significant anti-allergic and inflammatory activity with no side effects.
Additionally, the investigation of the antitype 4 allergies properties of the combined effect of 50% methanolic extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) and prednisolone also showed similar results as illustrated by the above 2 studies.
U-ext did not show an inhibitory effect on the swelling induced by PC-CD in divided doses of 100mg/kg immediately before and 16 h after the application of PC-CD, while it exhibited a significant therapeutic effect at a dose of 100 mg/kg or more once 24 h after the application.
Injection of the combination of U-ext (p.o.) and prednisolone (s.c.) simultaneously administered, exerted a greater inhibitory effect compared to that of prednisolone alone.
Researchers at the above studies wrote in the final report, "Bearberry leaf possesses a therapeutic effect against immuno-inflammation induced by PC-CD and also increases the inhibitory effect of prednisolone, and its active principle may be arbutin".
Taken altogether, herbal Herbal Arctostaphylos uva-ursi (Bearberry) may be considered a functional remedy for the prevention and combined with primary medicines for the treatment of type 4 hypersensitivity with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. V. Effect of water extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment].[Article in Japanese] by Matsuda H, Nakamura S, Tanaka T, Kubo M.(PubMed)
(2) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. III. Combined effect of arbutin and indomethacin on immuno-inflammation].[Article in Japanese] by Matsuda H, Tanaka T, Kubo M.(PubMed)
(3) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. I. Combined effect of 50% methanolic extract from Arctostaphylosuva-ursi (L.) Spreng. (bearberry leaf) and prednisolone on immuno-inflammation].[Article in Japanese] by Kubo M, Ito M, Nakata H, Matsuda H.(PubMed)
#Herbal #Artichoke Exerts a Strong Antioxidant Activity in Vitros, Studies Suggest
Kyle J. Norton
Oxidative stress is a condition caused by the imbalance of the ratio of free radicals and antioxidants produced by the host, leading to lipid and protein damage and alternation of cell DNA.
Oxidative stress has been found to initiate the onset of chronic diseases, including heart disease, diabetes, and cancers.
Free radicals are unstable atoms with an unpaired electron in the outer ring. Therefore, in order for them to become stable, free radicals are ready to steal or donate an electron from or to other atoms, leading to a chain reaction that can not be stopped until all electrons in the outer ring are paired or inhibited by antioxidants.
Overexpression of free radicals is bad. However, free radicals generated from cell metabolism may play a critical role in the synthesis of energy and essential molecules and boosting the immune system.
Antioxidants are stable atoms that inhibit oxidation.
In a healthy individual, antioxidant enzymes by the body are more than enough to accounter the expression of free radicals which bombard our body every day.
However, in less healthy people, intake of dietary antioxidants such as supplements or fruits rich with antioxidants may be the only option to improve levels of antioxidants in the body.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas, bloating, etc.
On finding a natural compound for the treatment of diseases associated with oxidative stress, researchers investigated artichoke antioxidant activity, compared to those of Ficus carica, and Morus nigra and their herbal mixture (CFM) in vitro, using CCl4-induced damage in HepG2 cells.
CFM at 1 mg/ml showed a 47.00% and 37.09% decline of aspartate transaminase and alanine transaminase, the oxidative stress markers, and an increase of the glutathione and superoxide dismutase 77.32% and 101.02%, the antioxidants produced by the host, comparable to CCl4 treated cells.
The antioxidant activity of fig and artichoke was attributed to the existence of different phenolic metabolites that act synergistically.
Dr. Youssef FS, the lead scientist said, "A herbal mixture composed of blackberry, artichoke, and fig could afford an excellent natural candidate to combat oxidative stress and counteract hepatic toxins owing to its phenolic compounds".
With an aim to reveal more information about the artichoke antioxidant effects, the researcher launched a comprehensive evaluation of the Jerusalem artichoke (Helianthus tuberosus L.) leaf and tuber extract.
According to the results from the analysis, leaf extract exhibited a higher content of phenols and flavonoids compared to tuber extracts (5.07 and 7.14 fold higher, respectively).
Application of tuber extract at concentrations (25-500 μg·ml- 1) had a positive effect on fibroblast growth.
In the fibroblast cell line, tuber and leaf extracts increase the expression of the ROS SOD-1 inactivating enzyme gene associated with apoptotic signaling and cell death without affecting the levels of Nox-4 antioxidant activity.
Dr. Nizioł-Łukaszewska Z and colleagues, after taking into account co and confounders wrote, "Jerusalem artichoke leaves and tubers extracts affect the cell proliferation and can alter the expression of genes related to oxidative stress".
Taken altogether, artichoke may be considered a functional and herbal remedy for the prevention and treatment of diseases associated with overexpression of reactive oxygen species (ROS), pending the confirmation of a larger sample and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Synergistic Hepatoprotective and Antioxidant Effect of Artichoke, Fig, Blackberry Herbal Mixture on HepG2 Cells and Their Metabolic Profiling Using NMR Coupled with Chemometrics by Youssef FS1, Labib RM1, Eldahshan OA1, Singab ANB. (PubMed)
(2) Antioxidant activity and cytotoxicity of Jerusalem artichoke tubers and leaves extract on HaCaT and BJ fibroblast cells by Nizioł-Łukaszewska Z1, Furman-Toczek D1, Zagórska-Dziok M. (PubMed)
Oxidative stress is a condition caused by the imbalance of the ratio of free radicals and antioxidants produced by the host, leading to lipid and protein damage and alternation of cell DNA.
Oxidative stress has been found to initiate the onset of chronic diseases, including heart disease, diabetes, and cancers.
Free radicals are unstable atoms with an unpaired electron in the outer ring. Therefore, in order for them to become stable, free radicals are ready to steal or donate an electron from or to other atoms, leading to a chain reaction that can not be stopped until all electrons in the outer ring are paired or inhibited by antioxidants.
Overexpression of free radicals is bad. However, free radicals generated from cell metabolism may play a critical role in the synthesis of energy and essential molecules and boosting the immune system.
Antioxidants are stable atoms that inhibit oxidation.
In a healthy individual, antioxidant enzymes by the body are more than enough to accounter the expression of free radicals which bombard our body every day.
However, in less healthy people, intake of dietary antioxidants such as supplements or fruits rich with antioxidants may be the only option to improve levels of antioxidants in the body.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas, bloating, etc.
On finding a natural compound for the treatment of diseases associated with oxidative stress, researchers investigated artichoke antioxidant activity, compared to those of Ficus carica, and Morus nigra and their herbal mixture (CFM) in vitro, using CCl4-induced damage in HepG2 cells.
CFM at 1 mg/ml showed a 47.00% and 37.09% decline of aspartate transaminase and alanine transaminase, the oxidative stress markers, and an increase of the glutathione and superoxide dismutase 77.32% and 101.02%, the antioxidants produced by the host, comparable to CCl4 treated cells.
The antioxidant activity of fig and artichoke was attributed to the existence of different phenolic metabolites that act synergistically.
Dr. Youssef FS, the lead scientist said, "A herbal mixture composed of blackberry, artichoke, and fig could afford an excellent natural candidate to combat oxidative stress and counteract hepatic toxins owing to its phenolic compounds".
With an aim to reveal more information about the artichoke antioxidant effects, the researcher launched a comprehensive evaluation of the Jerusalem artichoke (Helianthus tuberosus L.) leaf and tuber extract.
According to the results from the analysis, leaf extract exhibited a higher content of phenols and flavonoids compared to tuber extracts (5.07 and 7.14 fold higher, respectively).
Application of tuber extract at concentrations (25-500 μg·ml- 1) had a positive effect on fibroblast growth.
In the fibroblast cell line, tuber and leaf extracts increase the expression of the ROS SOD-1 inactivating enzyme gene associated with apoptotic signaling and cell death without affecting the levels of Nox-4 antioxidant activity.
Dr. Nizioł-Łukaszewska Z and colleagues, after taking into account co and confounders wrote, "Jerusalem artichoke leaves and tubers extracts affect the cell proliferation and can alter the expression of genes related to oxidative stress".
Taken altogether, artichoke may be considered a functional and herbal remedy for the prevention and treatment of diseases associated with overexpression of reactive oxygen species (ROS), pending the confirmation of a larger sample and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Synergistic Hepatoprotective and Antioxidant Effect of Artichoke, Fig, Blackberry Herbal Mixture on HepG2 Cells and Their Metabolic Profiling Using NMR Coupled with Chemometrics by Youssef FS1, Labib RM1, Eldahshan OA1, Singab ANB. (PubMed)
(2) Antioxidant activity and cytotoxicity of Jerusalem artichoke tubers and leaves extract on HaCaT and BJ fibroblast cells by Nizioł-Łukaszewska Z1, Furman-Toczek D1, Zagórska-Dziok M. (PubMed)
Turmeric's Curcuminoids Exert Significant Effects Against the Risk and Onset of #RheumatoidArthritis in Vivos, Researchers Say
Kyle J. Norton
Rheumatoid Arthritis (RA) is a type of arthritis associated with inflammation that affects mostly the flexible (synovial) joints and tissues and organs in the body.
The disease affects more women than men and generally occurs after the age of 40, causing the diminished quality of life of many older adults.
According to CDC, Musculoskeletal disorders (MSDs) affect over 52 million of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.
Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation.
A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes.
The symptoms of RA that affect
* The feet and joints
Patient with rheumatoid arthritis (RA) often associates to valgus deformities of the feet and deformities of gait due to body function in an effort to support the collapsing longitudinal arch of the foot.
* The gait
Dr. Weiss RJ. and the research team at the Karolinska Institutet showed that the kinematic and kinetic gait changes in rheumatoid arthritis (RA) patients are the result of a significant reduction in joint motions, joint moments, such as decreased hip flexion-extension range, hip abduction, knee flexion-extension range,
* The hands
The deformation of RA's hands can be described through the defects of bone ankylosis as a result of bone damage to the prolonged onset of the disease.
* The Muscle strength
The reduced muscle strength in patients with RA may contribute to the prevalence of functional limitations physically,
Other symptoms of RA include
* Rheumatoid Nodules
Rheumatoid nodules, lumps on the skin, closed to the joint have been found to affect the joints of patients with rheumatoid nodules.
* Conjunctival nodules
Although is rare in patients with rheumatoid arthritis, the appearance of the nodules may exhibit the
severity of the underlying disease.
* Morning stiffness
Morning stiffness, as a marker of inflammatory activity in reflecting functional disability and pain, is a very common symptom of patients with early rheumatoid arthritis.
If you have some of the aforementioned symptoms, you may have RA. Please make sure you check with your doctor to rule out the possibility.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential treatment for rheumatoid arthritis (RA), researchers investigated the protective activity of two different doses of a mixture of ginger and turmeric rhizomes powder suspended in distilled water (GTaq) against inflammation in an animal model.
Rats adjuvant-induced arthritis (AIA) by a single intradermal injection of 0.1 mL of Complete Freund's adjuvant (containing heat-killed Mycobacterium tuberculosis) into the palmar surface of the left hind paw were given orally and daily (for 28 consecutive days) distilled water as a vehicle, indomethacin (1.0 mg/kg body weight), or GTaq (200 or 400 mg/kg body weight) from the day of arthritis induction.
Suspended in distilled water (GTaq)are more effective (4.2-38.4% higher, P < 0.05-0.001) than indomethacin (a non-steroidal/anti-inflammatory drug) in alleviating the loss in body weight gain, the histopathological changes in ankle joints.
Blood leukocytosis and thrombocytosis associated with the inflammation are also reduced by being suspended in distilled water (GTaq).
Risk factors involved the risk of cardiovascular disease and kidney damage rat's adjuvant-induced arthritis was also decreased by the injection of GTaq.
Further differentiation of the anti-RA activity of GTaq, researchers found that the efficacy of the mixture was attributed to increasing the food intake and decreasing the systemic inflammation associated with the inhibition of polyarthritis, oxidative stress, and dyslipidemia.
Based on the findings, researchers said, "Ginger-turmeric rhizomes mixture may be effective against RA severity and complications as shown in an AIA rat model".
In order to obtain more information about turmeric anti-RA activity, researchers investigated the curcuminoid-containing turmeric extracts in the prevention or treatment of arthritis using streptococcal cell wall (SCW)-induced arthritis.
According to the tested assays, essential oil-depleted turmeric fraction containing 41% of the three major curcuminoids was efficacious in preventing joint inflammation at the start of the disease but not after, the onset of joint inflammation.
Interestingly, compared to other curcumin treatment groups, a commercial sample containing 94% of the three major curcuminoids was more potent in preventing arthritis in the same dose per weight.
These results strongly suggested only the three major curcuminoids found in the turmeric process antiarthritic effect, compared to the treatment of the whole food.
In other words, all compounds except three major curcuminoids of the crude turmeric extract may inhibit this protective effect.
Taken altogether, turmeric used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of RA, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
rheumatoid arthritis
(1) Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O. (PubMed)
(2) Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis by Funk JL1, Oyarzo JN, Frye JB, Chen G, Lantz RC, Jolad SD, Sólyom AM, Timmermann BN. (PubMed)
Rheumatoid Arthritis (RA) is a type of arthritis associated with inflammation that affects mostly the flexible (synovial) joints and tissues and organs in the body.
The disease affects more women than men and generally occurs after the age of 40, causing the diminished quality of life of many older adults.
According to CDC, Musculoskeletal disorders (MSDs) affect over 52 million of adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.
Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation.
A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes.
The symptoms of RA that affect
* The feet and joints
Patient with rheumatoid arthritis (RA) often associates to valgus deformities of the feet and deformities of gait due to body function in an effort to support the collapsing longitudinal arch of the foot.
* The gait
Dr. Weiss RJ. and the research team at the Karolinska Institutet showed that the kinematic and kinetic gait changes in rheumatoid arthritis (RA) patients are the result of a significant reduction in joint motions, joint moments, such as decreased hip flexion-extension range, hip abduction, knee flexion-extension range,
* The hands
The deformation of RA's hands can be described through the defects of bone ankylosis as a result of bone damage to the prolonged onset of the disease.
* The Muscle strength
The reduced muscle strength in patients with RA may contribute to the prevalence of functional limitations physically,
Other symptoms of RA include
* Rheumatoid Nodules
Rheumatoid nodules, lumps on the skin, closed to the joint have been found to affect the joints of patients with rheumatoid nodules.
* Conjunctival nodules
Although is rare in patients with rheumatoid arthritis, the appearance of the nodules may exhibit the
severity of the underlying disease.
* Morning stiffness
Morning stiffness, as a marker of inflammatory activity in reflecting functional disability and pain, is a very common symptom of patients with early rheumatoid arthritis.
If you have some of the aforementioned symptoms, you may have RA. Please make sure you check with your doctor to rule out the possibility.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a potential treatment for rheumatoid arthritis (RA), researchers investigated the protective activity of two different doses of a mixture of ginger and turmeric rhizomes powder suspended in distilled water (GTaq) against inflammation in an animal model.
Rats adjuvant-induced arthritis (AIA) by a single intradermal injection of 0.1 mL of Complete Freund's adjuvant (containing heat-killed Mycobacterium tuberculosis) into the palmar surface of the left hind paw were given orally and daily (for 28 consecutive days) distilled water as a vehicle, indomethacin (1.0 mg/kg body weight), or GTaq (200 or 400 mg/kg body weight) from the day of arthritis induction.
Suspended in distilled water (GTaq)are more effective (4.2-38.4% higher, P < 0.05-0.001) than indomethacin (a non-steroidal/anti-inflammatory drug) in alleviating the loss in body weight gain, the histopathological changes in ankle joints.
Blood leukocytosis and thrombocytosis associated with the inflammation are also reduced by being suspended in distilled water (GTaq).
Risk factors involved the risk of cardiovascular disease and kidney damage rat's adjuvant-induced arthritis was also decreased by the injection of GTaq.
Further differentiation of the anti-RA activity of GTaq, researchers found that the efficacy of the mixture was attributed to increasing the food intake and decreasing the systemic inflammation associated with the inhibition of polyarthritis, oxidative stress, and dyslipidemia.
Based on the findings, researchers said, "Ginger-turmeric rhizomes mixture may be effective against RA severity and complications as shown in an AIA rat model".
In order to obtain more information about turmeric anti-RA activity, researchers investigated the curcuminoid-containing turmeric extracts in the prevention or treatment of arthritis using streptococcal cell wall (SCW)-induced arthritis.
According to the tested assays, essential oil-depleted turmeric fraction containing 41% of the three major curcuminoids was efficacious in preventing joint inflammation at the start of the disease but not after, the onset of joint inflammation.
Interestingly, compared to other curcumin treatment groups, a commercial sample containing 94% of the three major curcuminoids was more potent in preventing arthritis in the same dose per weight.
These results strongly suggested only the three major curcuminoids found in the turmeric process antiarthritic effect, compared to the treatment of the whole food.
In other words, all compounds except three major curcuminoids of the crude turmeric extract may inhibit this protective effect.
Taken altogether, turmeric used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of RA, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
rheumatoid arthritis
(1) Protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis by Ramadan G1, El-Menshawy O. (PubMed)
(2) Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis by Funk JL1, Oyarzo JN, Frye JB, Chen G, Lantz RC, Jolad SD, Sólyom AM, Timmermann BN. (PubMed)
#YogaExercises Decrease the #Hormones Associated with Menstrual Cramp and Distress in Primary #Dysmenorrhea, Scientists Show
Kyle J. Norton
Attending yoga practice may ameliorate menstrual cramps and menstrual distress in women with primary dysmenorrhea, a 2016 study by respectable institute suggested.
Dysmenorrhea (painful menstruation) is a condition of severe uterine pain during menstruation. Some women may experience periodic pains during or prior to, or after menstrual periods in the lower abdomen as resulting of over production of certain hormones in the prostaglandins family.
Yoga, the accident technique practice for harmonized external and internal body well-being, through breath control, meditation, bodily movement, and gesture..... has been well-known for people in the Western world and some parts of Asia due to health benefits reported by various respectable institutes research and supported by health advocates.
According to the joint study led by the Department of Nursing, Kongyang University, women with primary dysmenorrhea engaged in a yoga program for 60 minutes once a week for 12 weeks, showed a significant reduction of menstrual pain and menstrual distress during and after the class.
In a total of 40 randomly selected undergraduate nursing students, with 20 each assigned to an exercise or a control group, a yoga program consisting of physical exercise combined with relaxation and meditation, for 60 minutes once a week for 12 weeks, improved a better pain score in comparison to control.
Others in the compared efficacy of three yoga poses (cobra, cat and fish poses) in reduced severity and duration of primary dysmenorrhea, suggested that all poses showed a significant difference in the pain intensity and pain duration in the post-tests compared with the pretest,(P < 0.05) but compared with the control group, yoga experimental group scores a significant improvement in the pain intensity and pain duration in the three menstrual cycles.
Importantly and promisingly, Chhatrapati Sahuji Maharaj Medical University, Yoga Nidra intervention duration was 35-40 minutes/day, five times/week for 6 months not only reduced pain and distress in women with primary but also reduced significant other forms of menstrual irregularity through modulating hormone expression.
In fact, in a total 150 subjects with menstrual irregularities; 126 of whom completed the protocol. yoga participants showed a decreased significantly thyroid-stimulating hormone (p<0.002), follicle-stimulating hormone (p<0.02), luteinizing hormone (p<0.001), and prolactin (p<0.02) compared control group.
Taking together, yoga therapy has a positively strong effect in reduced menstrual cramps and distress
in primary dysmenorrhea through the influence of hormone production.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of a Yoga Program on Menstrual Cramps and Menstrual Distress in Undergraduate Students with Primary Dysmenorrhea: A Single-Blind, Randomized Controlled Trial by Yang NY1, Kim SD2.(PubMed)
(2) Effect of three yoga poses (cobra, cat and fish poses) in women with primary dysmenorrhea: a randomized clinical trial by Rakhshaee Z1.(PubMed)
(3) Impact of Yoga Nidra on menstrual abnormalities in females of reproductive age by Rani M1, Singh U, Agrawal GG, Natu SM, Kala S, Ghildiyal A, Srivastava N.(PubMed)
Attending yoga practice may ameliorate menstrual cramps and menstrual distress in women with primary dysmenorrhea, a 2016 study by respectable institute suggested.
Dysmenorrhea (painful menstruation) is a condition of severe uterine pain during menstruation. Some women may experience periodic pains during or prior to, or after menstrual periods in the lower abdomen as resulting of over production of certain hormones in the prostaglandins family.
Yoga, the accident technique practice for harmonized external and internal body well-being, through breath control, meditation, bodily movement, and gesture..... has been well-known for people in the Western world and some parts of Asia due to health benefits reported by various respectable institutes research and supported by health advocates.
According to the joint study led by the Department of Nursing, Kongyang University, women with primary dysmenorrhea engaged in a yoga program for 60 minutes once a week for 12 weeks, showed a significant reduction of menstrual pain and menstrual distress during and after the class.
In a total of 40 randomly selected undergraduate nursing students, with 20 each assigned to an exercise or a control group, a yoga program consisting of physical exercise combined with relaxation and meditation, for 60 minutes once a week for 12 weeks, improved a better pain score in comparison to control.
Others in the compared efficacy of three yoga poses (cobra, cat and fish poses) in reduced severity and duration of primary dysmenorrhea, suggested that all poses showed a significant difference in the pain intensity and pain duration in the post-tests compared with the pretest,(P < 0.05) but compared with the control group, yoga experimental group scores a significant improvement in the pain intensity and pain duration in the three menstrual cycles.
Importantly and promisingly, Chhatrapati Sahuji Maharaj Medical University, Yoga Nidra intervention duration was 35-40 minutes/day, five times/week for 6 months not only reduced pain and distress in women with primary but also reduced significant other forms of menstrual irregularity through modulating hormone expression.
In fact, in a total 150 subjects with menstrual irregularities; 126 of whom completed the protocol. yoga participants showed a decreased significantly thyroid-stimulating hormone (p<0.002), follicle-stimulating hormone (p<0.02), luteinizing hormone (p<0.001), and prolactin (p<0.02) compared control group.
Taking together, yoga therapy has a positively strong effect in reduced menstrual cramps and distress
in primary dysmenorrhea through the influence of hormone production.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of a Yoga Program on Menstrual Cramps and Menstrual Distress in Undergraduate Students with Primary Dysmenorrhea: A Single-Blind, Randomized Controlled Trial by Yang NY1, Kim SD2.(PubMed)
(2) Effect of three yoga poses (cobra, cat and fish poses) in women with primary dysmenorrhea: a randomized clinical trial by Rakhshaee Z1.(PubMed)
(3) Impact of Yoga Nidra on menstrual abnormalities in females of reproductive age by Rani M1, Singh U, Agrawal GG, Natu SM, Kala S, Ghildiyal A, Srivastava N.(PubMed)
#Herbal #Bilberry Shows a Significant Effect Against Gradual Loss of Vision in Diabetes, Researchers Suggest
Kyle J. Norton
Macular degeneration is a condition caused by the deterioration of the small central portion of the retina, known as the macula.
Macular degeneration happened mostly in adults over 60 and is one of the major causes of vision loss.
The exact causes of macular degeneration are not identified. As of today, researchers cannot explain why some elderly are susceptible to macular degeneration while others do not.
There are 2 forms of macular degeneration
1. The dry form is caused by the presence of yellow deposits, called drusen under the retina, in the macula. However, the elderly with increased was not at a higher risk of macular degeneration.
2. The wet form is caused by the growth of abnormal blood vessels from the choroid, the vascular layer of the eye, underneath the retina.
Compared to the loss of vision of 10% of patients induced by the wet form, most patients of macular degeneration have the dry form which has been found to cause loss of some central vision.
Although aging is one of the prevalent risks of macular degeneration onset, smoking, family history, gender, ethnicity and long-term exposure to the sun, and genetic preposition are also some factors that may facilitate the early onset of the condition.
Some researchers suggested that macular degeneration may also be caused by an unhealthy diet.
Dr. Chung-Jung Chiu, the lead scientist in the analysis of the relationship of major American dietary patterns to age-related macular degeneration wrote, " (In the comparison of the 2 diets pattern) The Oriental pattern was characterized by higher intake of vegetables, legumes, fruit, whole grains, tomatoes, and seafood. The Western pattern was characterized by higher intake of red meat, processed meat, high-fat dairy products, French fries, refined grains, and eggs".
"For early AMD, multivariate-adjusted odds ratio (OR) from generalized estimating equation logistic analysis comparing the highest to the lowest quintile of the Oriental pattern score was ORE5O=0.74 (95% confidence interval (CI): 0.59–0.91; Ptrend=0.01), and the OR comparing the highest to the lowest quintile of the Western pattern score was ORE5W=1.56 (1.18–2.06; Ptrend=0.01). For advanced AMD, the ORA5O was 0.38 (0.27–0.54; Ptrend<0.0001), and the ORA5W was 3.70 (2.31–5.92; Ptrend<0.0001)".
These results strongly suggested the risk of AMD is many folds higher in people who follow the Western diet compared to those who follow the Oriental diet.
Bilberry is a species of low-growing shrub in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
Searching the list of natural compounds for the treatment of vision decline, scientists examined anthocyanins, bioactive compounds found in bilberry that are known to have antioxidant, anti-inflammatory, on macular degeneration.
Bilberry anthocyanosides (Vaccinium myrtillus L.), according to the differentiation was found to promote rhodopsin synthesis and regeneration, thus increasing the retinal sensitivity to changes in light intensity and visual acuity and dark adaptation.
The bioactive compound also was found in the promoted blood supply of the retina in the prevention of macular degeneration due to the aging-induced death of macula cells.
Where rhodopsin is the pigment-containing sensory protein that converts light into an electrical signal for vision in dim light
The improvement of the visual function by bilberry may have a strong effect against age-related macular degeneration, Dr. Vorob'eva IV, the lead scientists suggested.
Additionally, with an aim to reveal more information on bilberry anti-gradual loss of vision, researchers investigated the changes in clinical, functional, and morphological parameters of the retina in type 2 diabetes patients with diabetic retinopathy (DR) and those with combined fundus pathology (DR plus age-related macular degeneration).
The study included 180 patients (180 eyes) with type 2 diabetes divided into 6 groups of 30 each randomly assigned into group 1 consisting of patients with DRO,; group 2--DR1 without DM, group 3--DR1 with DM, group 4--DRO and "dry" AMD (AREDS 1-3), group 5--DR1 with no DM but with AMD (AREDS 1-3), and group 6--DR1 with DM and AMD (AREDS 1-3).
A drug containing lutein 6 mg, zeaxanthin 0.5 mg, vitamin C 60 mg, vitamin E 7 mg, vitamin A 1.5 mg, vitamin B2 1.2 mg, rutin 25 mg, zinc 5 mg, Selenium 25 mcg, and bilberry extract 60 mg was used for antioxidative therapy. Ginkgo biloba leaf extracts 60 mg was chosen as the radioprotector.
At the end of the experiment, researchers found that
* Macular thickness was statistically significant only in 3 and 6 (p<0.05)compared to only slight changes in other groups and light sensitivity of the macula showed a reduction, which was statistically significant in groups 4-6 before treatment.
* Injection of the supplements' antioxidant and angioprotective activities displayed a strong improvement of all parameters related to visual decline, including increased visual acuity.
Dr. the lead scientist wrote in the final report, "A combined antioxidant and double-dose radioprotective (240 mg) therapy appeared to be the most effective and can be considered not only a preventive but also a therapeutic measure in type 2 diabetes patients with initial stages of DR (DRO, DR1) or those with DR and DM or combined DR and AMD (AREDS 1-3)".
Taken altogether, bilberry may be considered a herbal remedy for the improvement of visual decline, particularly, in patients with macular degeneration, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(2) [Current data on the role of anthocyanosides and flavonoids in the treatment of eye diseases].[Article in Russian; Abstract available in Russian from the publisher] by Vorob'eva IV1, Vorob'eva IV. (PubMed)
(1) [Results of the use of antioxidant and angioprotective agents in type 2 diabetes patients with diabetic retinopathy and age-related macular degeneration].[Article in Russian; Abstract available in Russian from the publisher] by Moshetova LK1, Vorob'eva IV1, Alekseev IB1, Mikhaleva LG. (PubMed)
(3) The Relationship of Major American Dietary Patterns to Age-related Macular Degeneration by Chung-Jung Chiu, DDS, Ph.D., Min-Lee Chang, MS, Fang Fang Zhang, Ph.D., Tricia Li, MS, Gary Gensler, MS, Molly Schleicher, BS, and Allen Taylor, Ph.D. (PMC)
Macular degeneration is a condition caused by the deterioration of the small central portion of the retina, known as the macula.
Macular degeneration happened mostly in adults over 60 and is one of the major causes of vision loss.
The exact causes of macular degeneration are not identified. As of today, researchers cannot explain why some elderly are susceptible to macular degeneration while others do not.
There are 2 forms of macular degeneration
1. The dry form is caused by the presence of yellow deposits, called drusen under the retina, in the macula. However, the elderly with increased was not at a higher risk of macular degeneration.
2. The wet form is caused by the growth of abnormal blood vessels from the choroid, the vascular layer of the eye, underneath the retina.
Compared to the loss of vision of 10% of patients induced by the wet form, most patients of macular degeneration have the dry form which has been found to cause loss of some central vision.
Although aging is one of the prevalent risks of macular degeneration onset, smoking, family history, gender, ethnicity and long-term exposure to the sun, and genetic preposition are also some factors that may facilitate the early onset of the condition.
Some researchers suggested that macular degeneration may also be caused by an unhealthy diet.
Dr. Chung-Jung Chiu, the lead scientist in the analysis of the relationship of major American dietary patterns to age-related macular degeneration wrote, " (In the comparison of the 2 diets pattern) The Oriental pattern was characterized by higher intake of vegetables, legumes, fruit, whole grains, tomatoes, and seafood. The Western pattern was characterized by higher intake of red meat, processed meat, high-fat dairy products, French fries, refined grains, and eggs".
"For early AMD, multivariate-adjusted odds ratio (OR) from generalized estimating equation logistic analysis comparing the highest to the lowest quintile of the Oriental pattern score was ORE5O=0.74 (95% confidence interval (CI): 0.59–0.91; Ptrend=0.01), and the OR comparing the highest to the lowest quintile of the Western pattern score was ORE5W=1.56 (1.18–2.06; Ptrend=0.01). For advanced AMD, the ORA5O was 0.38 (0.27–0.54; Ptrend<0.0001), and the ORA5W was 3.70 (2.31–5.92; Ptrend<0.0001)".
These results strongly suggested the risk of AMD is many folds higher in people who follow the Western diet compared to those who follow the Oriental diet.
Bilberry is a species of low-growing shrub in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
Searching the list of natural compounds for the treatment of vision decline, scientists examined anthocyanins, bioactive compounds found in bilberry that are known to have antioxidant, anti-inflammatory, on macular degeneration.
Bilberry anthocyanosides (Vaccinium myrtillus L.), according to the differentiation was found to promote rhodopsin synthesis and regeneration, thus increasing the retinal sensitivity to changes in light intensity and visual acuity and dark adaptation.
The bioactive compound also was found in the promoted blood supply of the retina in the prevention of macular degeneration due to the aging-induced death of macula cells.
Where rhodopsin is the pigment-containing sensory protein that converts light into an electrical signal for vision in dim light
The improvement of the visual function by bilberry may have a strong effect against age-related macular degeneration, Dr. Vorob'eva IV, the lead scientists suggested.
Additionally, with an aim to reveal more information on bilberry anti-gradual loss of vision, researchers investigated the changes in clinical, functional, and morphological parameters of the retina in type 2 diabetes patients with diabetic retinopathy (DR) and those with combined fundus pathology (DR plus age-related macular degeneration).
The study included 180 patients (180 eyes) with type 2 diabetes divided into 6 groups of 30 each randomly assigned into group 1 consisting of patients with DRO,; group 2--DR1 without DM, group 3--DR1 with DM, group 4--DRO and "dry" AMD (AREDS 1-3), group 5--DR1 with no DM but with AMD (AREDS 1-3), and group 6--DR1 with DM and AMD (AREDS 1-3).
A drug containing lutein 6 mg, zeaxanthin 0.5 mg, vitamin C 60 mg, vitamin E 7 mg, vitamin A 1.5 mg, vitamin B2 1.2 mg, rutin 25 mg, zinc 5 mg, Selenium 25 mcg, and bilberry extract 60 mg was used for antioxidative therapy. Ginkgo biloba leaf extracts 60 mg was chosen as the radioprotector.
At the end of the experiment, researchers found that
* Macular thickness was statistically significant only in 3 and 6 (p<0.05)compared to only slight changes in other groups and light sensitivity of the macula showed a reduction, which was statistically significant in groups 4-6 before treatment.
* Injection of the supplements' antioxidant and angioprotective activities displayed a strong improvement of all parameters related to visual decline, including increased visual acuity.
Dr. the lead scientist wrote in the final report, "A combined antioxidant and double-dose radioprotective (240 mg) therapy appeared to be the most effective and can be considered not only a preventive but also a therapeutic measure in type 2 diabetes patients with initial stages of DR (DRO, DR1) or those with DR and DM or combined DR and AMD (AREDS 1-3)".
Taken altogether, bilberry may be considered a herbal remedy for the improvement of visual decline, particularly, in patients with macular degeneration, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(2) [Current data on the role of anthocyanosides and flavonoids in the treatment of eye diseases].[Article in Russian; Abstract available in Russian from the publisher] by Vorob'eva IV1, Vorob'eva IV. (PubMed)
(1) [Results of the use of antioxidant and angioprotective agents in type 2 diabetes patients with diabetic retinopathy and age-related macular degeneration].[Article in Russian; Abstract available in Russian from the publisher] by Moshetova LK1, Vorob'eva IV1, Alekseev IB1, Mikhaleva LG. (PubMed)
(3) The Relationship of Major American Dietary Patterns to Age-related Macular Degeneration by Chung-Jung Chiu, DDS, Ph.D., Min-Lee Chang, MS, Fang Fang Zhang, Ph.D., Tricia Li, MS, Gary Gensler, MS, Molly Schleicher, BS, and Allen Taylor, Ph.D. (PMC)
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