#Herbal #Ginger Inhibits Various Severe #VascularInflammatoryDiseases in Vivos, Scientists Show

Kyle J. Norton

In seeking a natural therapy with no side effects, scientists may have found a kitchen-pungent spice for the prevention and treatment of sepsis, according to studies.

Sepsis is a medical condition caused by the body's over-response to infection by releasing a large number of chemicals into the bloodstream, leading to a chemicals imbalance that can damage multiple organ systems.

The most common sites of infection leading to sepsis are found in older patients with the lungs, urinary tract, tummy (abdomen), and pelvis.

The causes of sepsis, in most cases, are involved in people with a weakened immune system or a severe infection that allows the inflammation to spread to the entire body.

Sepsis can be life-threatening due to the interruption of blood flow to the body caused by inflammation in the induction of blood vessel constriction.

The risk factors of sepsis include any medical conditions which can lead to a weakened immune system, such as AIDs and chemotherapy, the very young (immature immune system) and old (weakened immune system due to aging), pregnancy, and diabetes.

The most common symptoms of sepsis are associated with symptoms of reduced blood flow, including, a decrease in mental ability, and problems breathing. abnormal heart functions, fall in blood pressure, and fall in body temperature. unconsciousness.

If your child or yourself experiences some of the above symptoms, please call the emergency services right the away.

Some researchers suggested that people who are obese may have a negative implication on the immune system in fighting against infection that can cause sepsis.

Dr. A S Kolyva, the lead scientist said, "Sepsis is one of the most important causes of mortality in the developed world, where almost two-thirds of the population suffer from obesity".

And, "Obesity is associated with elevated TNFα adipose tissue production and increased oxidative stress biomarkers, promoting the proinflammatory response in septic patients".

These results strongly suggested that obesity may induce overexpression of proinflammatory cytokines that not only initiate the onset of sepsis and also increases the potential negative impact on the outcome.


Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a natural compound or food for the treatment of sepsis, researchers investigated the effects of a phenolic alkenone isolated from ginger in various pharmacological activities, including sepsis.

Injection of ginger exerted a modulatory effect on HMGB1-mediated septic responses and survival rate in a mouse model of sepsis.

The modulation of ginger was attributed to the suppression of the production of inflammatory cytokines such as TNF-α and IL-6 and the activation of proteins associated with inflammation induced by HMGB.

High mobility group box 1 (HMGB1) is a protein associated with the immune protective response by restoring the endothelial cells which line the interior surface of blood vessels and lymphatic vessels integrity.

Furthermore, the injection of ginger also inhibited HMGB1-mediated hyperpermeability and leukocyte migration in the initiation of inflammation in mice.

Moreover, in vivo, ginger inhibited lymphopoiesis (CLP) in stimulating the production of the release of HMGB1, sepsis-related mortality, and tissue injury.

In order to reveal more information about ginger antisepsis activity, researchers examined zingerone (ZGR), a bioactive compound isolated from ginger on TGFBIp-mediated septic responses.

Similar to that of the above, ZGR reduced the TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice.

Injection of ZGR suppressed TGFBIp-induced sepsis lethality and pulmonary injury.

Dr. Min G, the lead scientist, after taking into account co and confounders wrote in the final report, "ZGR could be a potential therapeutic agent for the treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway".

Taken together, ginger may be considered a functional remedy for the treatment of sepsis, pending the confirmation of a larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional\ Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Zingerone reduces HMGB1-mediated septic responses and improves survival in septic mice by Lee W1, Ku SK2, Bae JS. (PubMed)
(2) Suppressive effects of zingerone on TGFBIp-mediated septic responses by Min G1, Ku SK2, Lee T3, Bae JS4. (PubMed)
(3) The role of obesity in the immune response during sepsis by A S Kolyva,1 V Zolota,2 D Mpatsoulis,2 G Skroubis,3 E E Solomou,4 I G Habeos,5S F Assimakopoulos,1 N Goutzourelas,6 D Kouretas,6 and C A Gogos. (PMC).

#Herbal #ArtichokeLeaves Inhibit the Risk of #ChronicOxidativeStress, Researchers Reveal

Kyle J. Norton

Scientists may have found a herbal remedy that processed significant antioxidant activity against the onset and progression of oxidative stress-related diseases, according to studies.

Oxidative stress-related conditions are the class of diseases associated with cellular damage, including alternation of cell DNA, and damage of lipids and proteins.

The list of chronic diseases caused by cell oxidation is very long, including atherosclerosis, cancer, diabetes, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.

The most common causes of oxidative stress are overexpression of free radicals in the induction of a chain reaction.

Due to the unstable nature of free radicals with unpaired electrons in the outer ring, free radicals are ready to donate or intercept the electrons from other atoms, leading to a chain reaction that can not be stopped until the outring electron are either paired or inhibited by antioxidants.

In contrast to the general belief, the damage caused by free radicals are overly exaggerated, under normal condition, free radicals produced by internal or external source are needed by our body for cellular responses and immune function.

However, overexpression of free radicals also known as oxidative stress can be a danger to our health.

Oxidative stress can be acute or chronic. Acute oxidative stress is caused by a sudden burst of free radicals due to stress or external sources, in most cases can be inhibited by increasing antioxidant enzymes in the lung.

Chronic oxidative stress is caused by the unbalanced ratio of free radicals and antioxidant enzymes produced by our bodies. The condition is either caused by overexpression of free radicals or depletion of antioxidants enzymes or both.

There are many risk factors that cause oxidative stress. However, in the concerns of the prevalence of chronic diseases associated with the Western diet, some researchers suggested that the link the oxidative diseases in the Western world may be a result of the promotion of the Western diet over the past few decades.


Dr. Ildiko Erdelyi, the lead scientist said, "A Western-style diet (WD), defined by high-fat, low-calcium, and vitamin D content, is associated with increased risk of human colorectal cancer. Understanding molecular mechanisms altered by the WD is crucial to develop preventive and therapeutic strategies".

And, "consumption of a WD interferes with networks of related biological response pathways involving colonic lipid metabolism, oxidative stress, and the immune response".

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Scientists on finding a natural ingredient for the treatment of oxidative stress-related diseases examined the antioxidant activity of artichokes in the rat model.

Artichoke extracts showed good efficiency in the inhibition in vitro of LDL oxidation. Injection of artichoke extracts also increased the levels of antioxidant glutathione peroxidase against oxidative damage in the tested subjects compared to the control group.

Injection of artichoke extracts also inhibited the expression of a protein oxidation biomarker (2-Aminoadipic semialdehyde) compared to the control group.

In order to reveal more information about artichoke antioxidant activity, researchers examined the phenolic compound content and composition and the antioxidant activity of leaf parts [blades (SLB), petioles, and midribs (SPM)] from various Greek artichoke genotypes.


The leaf blades of most of the genotypes have a high content of flavonoids (mainly luteolin glycoside derivatives), which ranged between 49 and 78% of total phenolic compounds (TPC).

Petioles and midribs phenolic acids (mainly hydroxycinnamic acid derivatives) were the main phenolic compounds, ranging between 64 and 76% of TPC,

The antioxidant activity of blades was significantly higher than that of petiole and midribs for all the genotypes according to the tested assays.

The results of antioxidant differentiation suggested that artichoke leaves (blades, petioles, and midribs) show different bioactive compound profiles in stimulating the different levels of antioxidant properties.

Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of oxidative stress-related diseases through its antioxidant activity, pending the confirmation of a larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) In vitro antioxidant activities of edible artichoke (Cynara scolymus L.) and effect on biomarkers of antioxidants in rats by Jiménez-Escrig A1, Dragsted LO, Daneshvar B, Pulido R, Saura-Calixto F. (PubMed)
(2) Leaf parts from Greek artichoke genotypes as a good source of bioactive compounds and antioxidants by Petropoulos SA1, Pereira C, Barros L, Ferreira ICFR. (PubMed)
(3) Western-Style Diets Induce Oxidative Stress and Dysregulate Immune Responses in the Colon in a Mouse Model of Sporadic Colon Cancer by Ildiko Erdelyi,4 Natasha Levenkova,5 Elaine Y. Lin,8 John T. Pinto,9 Martin Lipkin,4Fred W. Quimby,6 and Peter R. Holt. (PMC)

#Emodin and Aloin Found in Herbal Cascara Sagrada Show a Significant Effect on #Mastitis and #LactationMastitis, According to Studies

Kyle J. Norton

Herbal Cascara sagrada processed bioactive compounds emodin and aloin may have a strong inhibited effect against the onset of mastitis according to studies.
Mastitis is an inflammation of breast tissue, affecting mostly mothers who are breastfeeding.
Most cases of mastitis are caused by a bacterial infection such as Staphylococcus aureus.

The most common risk factors of lactation mastitis are blocked duct(s) and restriction from a tight bra, attachment difficulties, and nipple pain during a feed were the significant predictors for mastitis in first-time breastfeeding mothers, according to the Journal of Human Lactation

The most common symptoms of mastitis are breast pain, swelling, warmth, and redness. Some patients may also experience symptoms of fever and chills.

Most cases of mastitis are treated with antibiotics, the medicine may be effective but it has been found epidemiologically to induce some side effects.


If you are currently taking one of them, please make sure you know all the side effects for preventive measures.

According to the study of 946 breastfeeding women from Michigan and Nebraska for the first 3 months postpartum or until they stopped breastfeeding to describe mastitis incidence, mastitis treatment, and any associations between mastitis occurrence and hypothesized host characteristics and behaviors. researchers found that mastitis is a very common condition in lactation women.


Telephone interviews at 3, 6, 9, and 12 weeks postpartum or until they ceased breastfeeding, a total of 9.5% reported provider-diagnosed lactation mastitis at least once during the 12-week period, with 64% diagnosed via telephone.

Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, its bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc., effect.

Besides the main compound of anthraquinones, other compounds include anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.

Researchers on finding herbal medicine for the treatment of mastitis examined Emodin, the major active compound of herbal Cascara Sagrada and Chinese herb Radix et Rhizoma Rhei effect on mastitis.

The mouse model of mastitis was induced by injection of LPS through the duct of the mammary gland. Pretreatment of emodin intraperitoneally with the dose of 1, 2, and 4 mg/kg respectively 1h before and 12h after induction of LPS showed a significant reduction of levels of proinflammatory cytokines, oxidative stress makers, and neutrophils, a type of white blood cell.

Emodin influenced nuclear factor kappa-B signal transduction pathway, a protein associated with the controls of transcription of DNA, cytokine production, and cell survival. by inhibiting activation of (nuclear transcription factor-kappaB (NF-κB) p65 involved) a protein complex involved in the immune response and (degradation inhibitor of NF-κB α (IκBα), and degradation of the cellular response to inflammation.

Furthermore, the efficacy of emodin is also attributed to the activation of the signaling pathways associated with the cellular responses to environmental stress and stimuli and the production of pro and anti-inflammatory cytokines.

The researcher wrote in the conclusion of the study, "Emodin could exert beneficial effects on experimental mastitis induced by LPS and may represent a novel treatment strategy for mastitis".


Moreover, in order to investigate the effects of herbal Cascara Sagrada and (Mastitis), researchers examined the herbal Cascara Sagrada and (Mastitis) therapeutic potential photogenically derived aloin, another major compound of the herb, mediated nanosilver particles (AAgNPs), prepared by reduction of silver nitrate with aloin, in Staphylococcus aureus-induced murine mastitis.

The study included a total of 40 female mice divided into five groups of eight animals each.
* Group I served as lactating control,

* Groups II-V inoculated with 20 μl of 24 h broth culture of S. aureus containing 4.0 × 105 cfu/quarter under ketamine anesthesia. After 6 h post inoculation, and

* Groups III and IV received 20 μl of aloin nanosilver (AAgNPs) through intramammary and intraperitoneal routes, respectively.

* Group V received antibiotic cefepime at 1 mg/kg body weight through the intraperitoneal route.

After 18 hours of post-treatment, injection of the compound showed a minimum inhibitory concentration of 21.8 ng/ml against S. aureus.

Nanosilver particles (AAgNPs) showed a significant reduction of 98% of the poly-morpho nuclear cell, a category of white blood cells in the mediation of the phase of inflammation, compared to only 50% in an antibiotic.

Taken together, herbal Cascara Sagrada processed abundantly bioactive compounds emodin and aloin may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of mastitis.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Emodin ameliorates lipopolysaccharide-induced mastitis in mice by inhibiting activation of NF-κB and MAPKs signal pathways by Li D, Zhang N, Cao Y, Zhang W, Su G, Sun Y, Liu Z, Li F, Liang D, Liu B, Guo M, Fu Y, Zhang X, Yang Z.(PubMed)
(2) Evaluation of the therapeutic potential of nanosilver particles synthesized using aloin in experimental murine mastitis model by Chaitanya Kumar TV, Muralidhar Y, Prasad PE, Prasad TN, Alpha Raj M.(PubMed)
(3) Risk Factors for Lactation Mastitis by Catherine Fetherston, RM, MSc, IBCLC. (Journal of Human Lactation)
(4) Lactation Mastitis: Occurrence and Medical Management among 946 Breastfeeding Women in the United States by Betsy Foxman Hannah D'Arcy Brenda Gillespie Janet Kay Bobo Kendra Schwartz. (American Journal of Epidemiology)

#ManukaHoney Containing Antibacterial Substance Methylglyoxal (MGO) In the Promotion of Oral Health, Researchers Suggest

Kyle J. Norton

Scientists may have found a natural alternative for the treatment of bad breath, according to studies.
Bad breath also known as halitosis, is a condition caused by an unpleasant odor of the mouth.

The causes of bad breath may be results from a combination of food, tobacco products, poor dental hygiene, health problems, dry mouth, oral infections, dental problems, or medications.

However, chemicals produced by some diseases, such as some cancers, and metabolic disorders, can cause a distinctive breath odor.

Chronic reflux of stomach acids (gastroesophageal reflux disease, or GERD) may be considered a major cause of bad breath in older adults.

The most common treatment of bad breath in the Western world is the use of mouth rinses and toothpaste if the bad breath is the result of bacterial infection.

People with bad breath due to lose-denture may need to see their dentists for correction.

However, if the bad breath is associated with dental diseases such as gum disease then seeing a related field specialist may be necessary.

Some researchers suggested that obesity is also tied to bad breath. The Tel Aviv University in examing the risk of bad breath in obese wrote, " the more overweight you are, the more likely your breath will smell unpleasant to those around you".

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one healthy sweet food for replacing the use of white sugar and artificial sweetener many people.

Researchers with an aim to find a natural remedy for the treatment of bad breath examined the Manuka honey anti-oral halitosis activity.

Manuka honey contains the typical antibacterial substance methylglyoxal (MGO) which has been found to process a strong antibacterial activity against oral bacteria.

The study to compare the before and after intake of Manuka honey or Acacia honey and their halitosis effect included 10 healthy subjects (average age: 36 years old, 5 men and 5 women).


The concentrations of volatile sulfur compounds (VSCs) produced by the oral bacteria and anaerobic bacteria in the mouth decreased after intake of both honey, but faster in the Manuka honey compared to those of Acacia honey.

Manuka honey showed 127 times higher amounts of MGO than acacia honey, according to analysis.

These results clearly suggested that the efficacy of honey in the inhibition of bad breath was attributed to the strong antibacterial activity of MGO.


In order to reveal more information about honey's anti-bad breath activity, researchers investigated the effect of honey in preventing gingivitis and dental caries.


In a total of 20 female orthodontic patients between the ages of from12–18 participated in this randomized controlled study, researchers compared the effect of honey with either 10% sucrose or 10% sorbitol which served as positive and negative controls.


Honey injection showed significant differences in pH compared to the pH observed in the sorbitol group. The maximum pH drop occurred at 5 min in both the honey and sucrose groups and the pH following sucrose exposure fell <5.5 and was associated with a 30 min recovery time.

Furthermore, bacterial counts were in the honey treatment group significantly reduced compared to the other treatment groups.

Moreover, honey also significantly inhibited the growth of all studied strains compared to the inhibition observed with antibiotics.

Taken together, honey, particularly, Manuka honey or Acacia honey may be considered functional remedies for the prevention and treatment of oral breath, pending to the confirmation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Decrease of halitosis by intake of manuka honey by H. SHIGA, A. JO, Keiji Terao Kobe University. (Research Gate)
(2) Effect of honey in preventing gingivitis and dental caries in patients undergoing orthodontic treatment by AL-Dany A. Atwa, a Ramadan Y. AbuShahba, a Marwa Mostafa,b and Mohamed I. Hashemc. (PMC)
(3) Overweight People More Likely To Have Bad Breath, Study Finds by the Tel Aviv University

#Curcumin Found in #Turmeric Induces Cancer Cell Apoptosis at the Early Onset of #CervicalCancer, in Vitro

By Kyle J. Norton

The cervix is the lower part of the uterus that opens at the top of the vagina. The cervix acts a transition area for the vaginal lining (squamous epithelium) to the uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus.
Cervical cancer is a medical condition caused by cells growing abnormally in the cervix uteri or cervical area due to the alternation of cell DNA.

Most cases of cervical cancer begin in the cells on the surface of the inner lining tissue in the cervix uteri or cervical area before penetrating into deeper layers to form a tumor by proliferation.

According to the statistics provided by the American Cancer Society, in 2019, approximately 13,170 new cases of invasive cervical cancer will be diagnosed and cervical cancer will cause the death of 4,250 American women.

Today, due to the introduction of the pep test, the cervical cancer death rate has dropped significantly as cancer can be diagnosed at a very early stage. Most cases of cervical cancer are diagnosed in women between the ages of 35 and 44.

The 5-year survival overall rate for all women with cervical cancer is 66%. However, the 5-year survival rate in women with invasive cervical cancer diagnosed at the early stage is 92%.

Pre-cervical cancer is the early stage of abnormal cell changes in the cervical tissue, if left untreated, the incidence can develop into true invasive cervical cancer.

Gardasil, a vaccine, has been used to prevent pre-cervical cancer from the infection of two types of HPV approved by the U.S. Food and Drug Administration in 2006. It is for women's benefit to take this vaccine if you are sexually active with several partners.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to find a potential compound for the treatment of cervical cancer, researchers investigated the anti-cervical cancer activity of curcumin in vitro.

According to the tested assays, in human cervical cancer HeLa cells curcumin-induced cell death through the induction of DNA damage, and chromatin condensation.

More precisely, the efficacy of curcumin at 13 µM increased the protein levels associated with DNA damage and repair, leading to cancer cell apoptosis at the early onset of cervical cancer.

Additionally, in HPV infections related to HPV 16 and 18 types, that cause cervical cancer, researchers evaluated curcumin's chemopreventive and anticancer effects against both HPV-related and nonrelated cervical cancers.

In benzo(a)pyrene (Bap), carcinogen-induced pathological cervical lesions of women who smoke, administration of curcumin exerted a significant effect in the inhibition of the Bap-induced signaling pathway and molecular markers dysregulation.

In other words, proteins associated with the early onset of cervical cancer caused by benzo(a)pyrene (Bap) inhibited the injection of curcumin by reducing levels of oxidative stress marker.

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of cervical cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin causes DNA damage and affects associated protein expression in HeLa human cervical cancer cells by Shang HS1, Chang CH2, Chou YR3, Yeh MY4, Au MK5, Lu HF6, Chu YL7, Chou HM8, Chou HC8, Shih YL8, Chung JG. (PubMed)
(2) Curcumin as a multifaceted compound against human papilloma virus infection and cervical cancers: A review of chemistry, cellular, molecular, and preclinical features by Teymouri M1, Pirro M2, Johnston TP3, Sahebkar A. (PubMed)
(3) Cervical Cancer by Kyle J. Norton

The Effects of #Yoga Exercise on #ChronicPain Clinical Trials Show

Kyle J. Norton

People attending yoga lessons long terms demonstrated superior performance on the measure of implicit motor imagery in reduced severity of chronic pain, compared nonyoga participants.

This implication of superior motor imagery performance in yoga participants actually promoted cortical re-organization in alleviating pain associated with imagination and observation of movement, without triggering the protective pain response.

Yoga is an ancient practical technique of India, including breath control, meditation, bodily movement, and gesture,..... with an aim to achieve harmonization of the body, mind, and spirit.

Chronic pain is persistence of pain last more 12 weeks and longer.

Dr. Hartnoll SH, the lead researcher said, " Yoga practice is associated with superior motor imagery performance; an association that may be important in explaining the established rehabilitative value of yoga for chronic pain".

In a total of 36 participants (18 yoga, 18 nonyoga) matched for age, sex, and handedness, undertook the hand laterality recognition task yoga group scored a magnificent faster result compared to controls (p < 0.05), including greater accuracy, faster responses to images corresponding with the dominant limb and with awkward postures, as indicated motor imagery assay.

Additionally, researchers also emphasized that yoga-practiced attendees also expressed a motor imagery performance, involving awkward postures in the compared control group.

Other studies insisted that mind-body techniques such as yoga may be used as pain and symptom management in conjunction with non-opioid pain medication for certain chronic pain as well as improved quality of life.

Interestingly, in a study to evaluate the regular yoga practice influenced a left/right judgment task in compared to people who do not, participants after viewing 40 photographs of a model with their head turned to the left or right, a yoga group and non yoga scored a more faster and more accurate (p=0.001) at making left/right neck rotation judgement than they were at making left/right-hand judgments, regardless of group. These results may be an indication that yoga may have chronic pain efficacy through other aspects unrelated to certain tasks.

Taking together, yoga may be a safe and effective technique used for the treatment of chronic pain through many mechanisms, including superior motor imagery performance.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Yoga practice is associated with superior motor imagery performance by Hartnoll SH1, Punt TD1.(PubMed)
(2) Are people who do yoga any better at a motor imagery task than those who do not? by Wallwork SB1, Butler DS2, Wilson DJ1, Moseley GL3. (PubMed)
(3) A Mind-Body Approach to Pediatric Pain Management by Brown ML1,2, Rojas E3, Gouda S4.9(PubMed)
(4) The effects of graded motor imagery and its components on phantom limb pain and disability in upper and lower limb amputees: a systematic review protocol Katleho Limakatso, Lieselotte Corten and Romy Parker(Systematic Reviews)

#Ginger Processes Anti #ChronicMildStress, Symptoms of #Depression and #Arteriosclerosis In Vivos, Researchers Find

By Kyle J. Norton

Scientists may have found a natural remedy which processes the potential to treat chronic mild stress, according to studies.
Acute stress is a natural and emotional reaction that arises in response to a terrifying or traumatic event or witnessing a traumatic event. People react to acute stress differently depending on life experiences.

Chronic stress, a medical condition is a result of a person who can not respond to emotional pressure properly, leading to traumatic stress which he or she can not control.

Untreated ongoing chronic stress has been found to exacerbate many serious health conditions, including depression, anxiety, and personality disorders.


Epidemiological studies suggested that certain physical health problems are also associated with patients with long-term stress, including heart disease, high blood pressure, abnormal heart rhythms, heart attacks, and stroke.


There are many risk factors involving the onset of chronic stress. However, job-related chronic stress has been found in most American adults in the Western world.


The American Institute of Stress in examing the chronic stress in American adults wrote, "Numerous studies show that job stress is far and away the major source of stress for American adults and that it has escalated progressively over the past few decades. Increased levels of job stress as assessed by the perception of having little control but lots of demands have been demonstrated to be associated with increased rates of heart attack, hypertension, and other disorders".

According to the American Workplace VII statistics, 80% of workers feel stress on the job, nearly half say they need help in learning how to manage stress and 42% say their coworkers need such help.


Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding natural ingredients or whole food for the treatment of chronic mild stress (CMS), a major contribution to atherosclerosis in the previous study examined the effects of 6-gingerol (6-Gin), a phenolic component of ginger (Zingiber officinale) anti-chronic stress activity.

6-gingerol (6-Gin) has long been found to process numerous pharmacological properties, such as anti-inflammatory and cardioprotective effects, according to epidemiological studies.

CMS ApoE-/- mice used in the study were given a high-fat diet (HFD) to induce the development of atherosclerosis in-fed before administrating 6-Gin.

Mice were exposed to CMS for 20 weeks, at week 5, they were fed with a high-fat diet (HFD), then received 6-Gin (20 mg/kg/day, intragastrically) treatment.

CMS before the application of a high-fat diet exerted a significant effect in reducing body weight gain, sucrose preference, and locomotor activity, the expression of some of the core symptoms of depression.

Furthermore, CMS mice fed with a high-fat diet (HFD) after week 5 also showed increased plaque formation, elevation of plasma total cholesterol, triglyceride, low-density lipoprotein cholesterin, and proinflammatory cytokines including TNF-α, IL-1β, and IL-6, all indicated the development of atherosclerotic lesions.

However, injection of 6-Gin not only reduced the expression induced by a high-fat diet but modulated the function of enzymes activated glucose and fatty acid uptake and oxidation, catalyzed the committed step in fatty acid synthesis, produced cholesterol and other isoprenoids, particularly the lipid synthesis in the liver tissues.

These results suggested the role of ginger in alleviating atherosclerotic lesions and reversed the expression levels of lipid profiles and inflammatory cytokines in stressed mice.

Dr. Wang S, the lead scientist wrote, "The antiatherosclerotic effects of 6-Gin is mediated in part by the AMPK signaling pathway, which is closely associated with cholesterol synthesis and lipid accumulation".

Where AMP-activated protein kinase (AMPK) plays a key role as a master regulator of cellular energy homeostasis, in response to low glucose, hypoxia, ischemia, and heat shock.

Additionally, CMS also showed an improvement in several aspects of chronic stress on the injection of 6-Gin.

The finding clearly suggested 6-Gin attenuates arteriosclerosis in ApoE-/- mice exposed to CMS and HFD, and it may be a potential therapeutic agent for the treatment of atherosclerosis similar to that of conventional medicine.


Taken altogether, ginger-processed abundantly bioactive compound 6-gingerol may be considered a functional remedy for the prevention and combined with the primary medicine for the treatment of chronic mild stress and atherosclerosis, pending the confirmation of large sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) 6-Gingerol Ameliorates Behavioral Changes and Atherosclerotic Lesions in ApoE-/- Mice Exposed to Chronic Mild Stress by Wang S1, Tian M2, Yang R1, Jing Y1, Chen W1, Wang J1, Zheng X1, Wang F. (PubMed)
(2) Transforming stress through awareness, education, and collaboration by AIS