#Artichoke #Extract Shows Significant Liver Protective Activities in Vivos, According to Studies

Kyle J. Norton

The hepatoprotective or liver protective effect is an action that maintains the liver's healthy functioning against any harmful toxins.
The liver is the largest internal organ in the human body and the only organ which can regenerate itself. The liver is the first line of the bodily toxin defense by filtering the blood that comes from the digestive tract, before passing it to the rest of the body.

Furthermore, the liver also processes a function of detoxifying chemicals and metabolizes drugs.

Symptoms of liver diseases include jaundice, abdominal pain, swelling, swelling in the legs and ankles, itchy skin, dark urine, pale stool color, and a tendency to bruise easily.

If you experience some of the above symptoms, please make sure that you check with your doctor to rule out the possibility of liver disease.

Most cases of liver disease are associated with hepatitis viral infection and autoimmune diseases. However, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.

Dr. Suthat Liangpunsakul, the lead scientist, in the comparison of alcoholic disease in different regions, wrote, "Alcoholic liver diseases (ALD) comprise a spectrum of clinical disorders and changes in liver tissue that can be detected by pathology analysis. These range from steatosis to more severe signs and symptoms of liver disease associated with inflammation, such as those observed in patients with alcoholic hepatitis or cirrhosis".

And, " Inter-individual differences in susceptibility to the toxic effects of alcohol have been extensively studied—they include a pattern of alcohol consumption, sex, environmental factors (such as diet), and genetic factors, which vary widely among different parts of the world. ALD is becoming more common in many parts of Asia but is decreasing in Western Europe".

The results clearly and strongly suggested that reducing the intake of alcohol and following a healthy diet pattern is the best way to decrease the risk of liver diseases, including ALD.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detox agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Scientists on finding a natural ingredient that processes liver protective effects evaluated the preventive effects of ethanolic extract from artichoke against acute alcohol-induced liver injury in mice.

Selected male mice were treated with an ethanolic extract of artichoke (0.4, 0.8, and 1.6 g/kg body weight) by gavage once daily before administrated up to 40% alcohol (12 mL/kg body weight) orally 1 h after artichoke treatment for 10 consecutive days.

Injection of artichoke extract not only significantly prevented elevated levels of aspartate aminotransferase, alanine aminotransferase, and the liver oxidative stress markers but also reduced the levels of triglyceride, total cholesterol.

Artichoke treatment mice also restored the levels of antioxidant enzymes which were reduced by the injection of alcohol.

According to the immunohistochemical analysis, artichoke also suppressed the levels of toll-like receptor (TLR) 4 which plays a critical role in the production of several pro-inflammatory, antiviral, and anti-bacterial cytokines and protein, nuclear factor-kappa B (NF-κB) associated with liver cells apoptosis in liver tissues.

The results indicated a liver protective activity in artichoke was attributed to the inhibition of the proinflammatory proteins in acute alcohol-induced liver injury mice.

In order to reveal more information about the liver protective effect of artichokes, researchers examined the herbal medicine against liver fibrosis, the main pathology of schistosomiasis, and its complications are the major cause of death in infected cases.

Mice selected for the study infected with Schistosoma mansoni (S. mansoni) were divided into 5 groups. The first three groups were given artichoke leaf extract (ALE), ALE + praziquantel (PZQ), and PZQ respectively. The 4th was a positive control and the 5th was the negative control group. and were compared to PZQ.

Injection of ALE and ALE + praziquantel (PZQ) caused a significant reduction of granuloma diameter, improvement of liver functions, and liver fibrosis.

Furthermore, ALE induced statistically significant changes in hepatic stellate cell (HSCs) distribution.

Moreover, ALE also reduced granuloma size by increasing HSCs recruitment inside granuloma and limited liver fibrosis by their inhibition in the peri- and inter-granuloma liver tissue.

Unfortunately, although, the herbal extract exerted a strong liver protective activity, it failed to treat S. mansoni infection.

Taken altogether, artichoke may be considered a functional remedy for preventing and treating liver disease, pending the confirmation of a large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Liver protective effects
(1) Protective Effects of Ethanolic Extracts from Artichoke, an Edible Herbal Medicine, against Acute Alcohol-Induced Liver Injury in Mice by Tang X1, Wei R2, Deng A3, Lei T. (PubMed)
(2) Artichoke leaf extract protects liver of Schistosoma mansoni infected mice through modulation of hepatic stellate cells recruitment by Sharaf El-Deen SA1, Brakat RM2, Mohamed ASED. (PubMed)
(3) [Artichoke--untapped potential of herbal medicine in the treatment of atherosclerosis and liver diseases].[Article in Polish] by Horoszkiewicz M1, Kulza M, Malinowska K, Woźniak A, Seńczuk-Przybyłowska M, Wachowiak A, Florek E.(PubMed)
(4) Alcoholic Liver Disease in Asia, Europe, and North America by Suthat Liangpunsakul, Paul Haber, and Geoff McCaughan. (PMC)

#Honey Shows to Speedup New Bone Formation in Vivos, According to Studies

Kyle J. Norton

Bone healing is a natural process of broken bone healing. The bone healing process goes through three overlapping stages, including inflammation, soft and callus production, and bone remodeling.
Improper bone healing occurred when two ends of the broken bone are not lined up properly, leading to the bone healing with a deformity called a malunion.

Most cases of improper bone healing have been found to involve angulation (bend) and/or rotation flexibility or extension. In some cases, improper bone healing can also cause stiffness in the finger, hand, wrist, or elbow.

If you experience some of the above symptoms after a broken bone, you may have improper bone healing. Please check with your doctor to rule out the possibility.

Some researchers concerned about the risk of improper bone healing in obese patients wrote, "Obesity is a risk factor for various orthopedic diseases, including fractures. Obesity's influence on circulating hormones and cytokines and bone mineralization ultimately influence the body's osteogenic response and bone mineralization, potentially increasing the risk of fracture and impacting fracture healing".

Luckily, the doctor continued, "Obese/overweight children did not have a delay in release to activities compared with children of normal weight".

The results strongly suggested the correlation between obesity and the risk of bone fracture and fracture healing in children.

Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Researchers on finding a natural remedy for speed-up bone healthy investigation honey activity on
alveolar osteitis (OA).

Alveolar osteitis (AO) is a complication of tooth extraction.

50 patients of AO were included in the study. After cleansing of the affected socket, honey dressings applied were changed daily for the first 2 days and then alternatively.

Honey application sped up the bone and granulation tissue healing and gingiva healing in about one week on most patients.

According to the reading of the CRP levels, treatment of AO with honey dressing showed a significant decrease from the pre-treatment values, an indication of fast recovery from inflammation.


The microbiological assay also showed the presence of normal commensal flora at AO sites including Streptococcus, Staphylococcus, and Enterococcus.

The results suggested that honey topical dressing speeds up bone healing and tissue recovery by inhibiting microbial overexpression and the production of pro-inflammatory cytokines.


In order to reveal more information about the bone healing of honey, researchers examined the honey on the healing of mandibular bone defects in a rat model.

24 wild-type Wistar rats included in the study were shaved, disinfected, and extraoral incised with a 2 × 2 mm defect at the mandibular angle. Only the experimental group defect was filled with sterile honey.


After 4 weeks, the defects were filled in four samples of the honey treatment group, compared to all samples of the control group which is still in the mineralization stage.


According to the histomorphometric assay, the honey treatment showed a significant improvement in the mean new bone formation compared to those of the control group, both after 2 and 4 weeks.

Taken together, honey may speed up bone healing without inducing any side effects, pending the confirmation of a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as  the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effect of Topical Honey on Mandibular Bone Defect Healing in Rats by Hajizadeh F1, Derakhshan B2, Peimani A3, Abbasi Z. (PubMed)
(2) Effects of honey in the management of alveolar osteitis: A study by Soni N1, Singh V1, Mohammad S1, Singh RK1, Pal US1, Singh R2, Aggrwal J3, Pal M. (PubMed)
(3) Does obesity affect fracture healing in children? by Lee RJ1, Hsu NN, Lenz CM, Leet AI. (PubMed)

#Yoga Therapy Combined With Sleep Hygiene Education In the Treatment #ChronicInsomnia, Scientists Say

Kyle J. Norton

Yoga might be effective for the treatment of chronic insomnia syndrome, the Universidade Federal de São Paulo study suggested.
Insomnia is a condition characterized by trouble sleeping, affecting over 10% of the worldwide population, particularly women.

Yoga, the accident technique practice for harmonized external and internal body well-being, through breath control, meditation, bodily movement, and gesture..... has been well known for people in the Western world and some parts of Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

In a study of postmenopausal women in the range of 50 to 65 years old not undergoing hormone therapy, diagnosed with an apnea-hypopnea index less than 15, and insomnia, randomly assigned to one of three groups, control, passive stretching, and yoga, researchers filed the following results
1. Yoga attendees displayed a strong improvement in insomnia through reduced climacteric symptoms and enhanced quality of life and resisted stress.
2. Yoga groups demonstrated a reduction in insomnia severity in compared to significantly higher in the control and passive-stretching groups.

Additionally in the investigated symptoms of insomnia include excessive daytime sleepiness, difficulty falling asleep, difficulty staying asleep, and waking up too early in cancer patients, researchers stated that yoga is a well-tolerated and safe mode of exercise with promising in improving insomnia symptoms among cancer patients.

Therefore, Yoga should be used as secondary clinical recommendations treatment conjunction with standard therapy for the treatment of insomnia in this population, researchers opinionated.

Interestingly, in a randomized, controlled clinical trial to evaluate MBSR as a treatment for chronic insomnia of 18 adults completed an 8-week mindfulness-based stress reduction (MBSR) program, researchers at the University of Minnesota filed the report as follows
1. Yoga, mindfulness-based stress reduction (MBSR) program intervention do not induce more sleeping time, but sleeping better, waking more refreshed, feeling less distressed,.......
2. Participants also expressed that practicing meditation and following sleep hygiene guidelines became priorities.
3. The program also helps patients to sleep faster

Dr. Hubbling A, the lead author said, "(Yoga)mindfulness training in a group format, combined with sleep hygiene education, is important for effective application of MBSR as a treatment for chronic insomnia".

Taking together, Yoga as an integrated form of exercise, including mindfulness training may be effective in improving chronic insomnia by enhancing psychological and physical aspects.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionalss Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Yoga decreases insomnia in postmenopausal women: a randomized clinical trial by Afonso RF1, Hachul H, Kozasa EH, Oliveira Dde S, Goto V, Rodrigues D, Tufik S, Leite JR(PubMed).
(2) Yoga for the Treatment of Insomnia among Cancer Patients: Evidence, Mechanisms of Action, and Clinical Recommendations by Mustian KM1, Janelsins M1, Peppone LJ1, Kamen C1.(PubMed)
(3) How mindfulness changed my sleep: focus groups with chronic insomnia patients by Hubbling A, Reilly-Spong M, Kreitzer MJ, Gross CR1.(PubMed)

#Healthyfood #Tomatoes Inhibit Hepatic Steatosis through Genes Involved Fatty Acid Oxidation in Vivos, Researchers Show

Kyle J. Norton

Hepatic steatosis is a medical condition caused by the accumulation of fat in the liver.
In other words, if the intrahepatic fat of your liver is more than 5% of your liver weight, you are considered to have hepatic steatosis. Over time, untreated hepatic steatosis can lead to liver metabolic dysfunction, inflammation, and advanced forms of nonalcoholic fatty liver disease.

Epidemiologically, hepatic steatosis has been found to induce complications in patients with obesity, alcohol intoxication, and/or hepatic disorders.

There are several mechanisms involved in the accumulation of intrahepatic fat, including increased flux of fatty acids to the liver, increased de novo lipogenesis, and/or reduced clearance through β-oxidation or very-low-density lipoprotein secretion.


People who are obese, having the condition of insulin resistance or diabetes, dyslipidemia, hypertension, metabolic syndrome, rapid weight loss, and using hepatotoxic medications total parenteral nutrition (TPN) are at an increased risk of hepatic steatosis.


Out of many prevalent factors involved in the onset of hepatic steatosis, some researchers suggested that the promotion of the Western diet over the past few decades in the Western world may have a strong and negative impact that acelerrates the incidence onset.


Dr. Michael D. Roberts, the lead scientist wrote, "Six weeks of WD feeding caused hepatic steatosis development as evidenced by the 2.25-fold increase in liver triacylglycerol content, but did not induce advanced liver disease (i.e., no overt inflammation or fibrosis)".


And, "sub-chronic WD feeding appears to increase hepatic steatosis development over a 6-week period but only induces select inflammation-related liver transcripts, mostly acute phase response genes. These findings continue to outline the early stages of NAFLD development prior to overt liver inflammation and advanced liver disease".


The results strongly suggested the risk of the Western diet on hepatic steatosis developing.


Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In the urgency to discover healthy foods for the treatment of hepatic steatosis, researchers examined the effect of tomato consumption on biomarkers and gene expression related to lipid metabolism in rats with induced steatosis.

The study included 24 adult male Sprague-Dawley rats (8 weeks old) randomly assigned to (n = 6 rats/group) four experimental groups, including NA (normal diet and water), NL (normal diet and tomato juice), HA (high-fat diet and water) and HL (high-fat diet and tomato juice).

According to the tested assays, before the treatment of tomato, the HA group fed high-fat diet-induced hepatic steatosis confirmed by the levels of alanine aminotransferase and aspartate aminotransferase, an indication of liver stress and injury.

Tomato treated group showed a significant increase in levels of lycopene and its secondary metabolites in the livers of these animals, particularly in HL than in the NL group, apparently due to higher absorption (63.07 vs. 44.45%).

Furthermore, tomato treated group protected the liver by alleviating oxidative stress through the reduction of isoprostanes in the urine observed by increased levels of antioxidant enzymes.

Moreover, levels of high-density lipoprotein were also increased in the HL group compared to the HA group.

Interestingly, overexpression of several genes related to lipid metabolism was also found in the HL group compared to nontreatment groups.

In other words, tomatoes inhibited the onset and progression of hepatic steatosis in high-fat diet mice by inhibiting liver oxidative stress and enhancing lipid metabolism.

Dr. Martín-Pozuelo G, the lead scientist wrote, "The consumption of tomato juice and tomato products reduced hallmarks of steatosis, plasmatic triglycerides, and very low-density lipoproteins, and increased lipid metabolism by inducing an overexpression of genes involved in more efficient fatty acid oxidation".

Taken altogether, tomatoes may be considered a dietary supplement for the prevention and treatment of hepatic steatosis, pending to large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The effect of tomato juice supplementation on biomarkers and gene expression related to lipid metabolism in rats with induced hepatic steatosis by Martín-Pozuelo G1, Navarro-González I, González-Barrio R, Santaella M, García-Alonso J, Hidalgo N, Gómez-Gallego C, Ros G, Periago MJ. (PubMed)
(2) Lipid biomarkers and metabolic effects of lycopene from tomato juice on liver of rats with induced hepatic steatosis by Bernal C1, Martín-Pozuelo G, Lozano AB, Sevilla A, García-Alonso J, Canovas M, Periago MJ. (PubMed)
(3) Western diet-induced hepatic steatosis and alterations in the liver transcriptome in adult Brown-Norway rats by Michael D. Roberts, C. Brooks Mobley, Ryan G. Toedebush, Alexander J. Heese, Conan Zhu,Anna E. Krieger, Clayton L. Cruthirds, Christopher M. Lockwood, John C. Hofheins,Charles E. Wiedmeyer, Heather J. Leidy, Frank W. Booth, and R. Scott Rector. (PMC)

#Ginger Improves the Fat and Glucose Metabolisms in People Who Are Under Constant Psychological Stress, Researchers Find

Kyle J. Norton

Scientists may have found a pungent spice that improves fat and glucose metabolism under stress, according to studies.
Psychological stress is the expression of emotion and physiology when events happened to an individual going beyond his/her coping ability.

However, the coping resources for coping with the stress of each individual are quite different. Some can cope better than others when dealing with the same unfortunate events.

Psychologic stress was found to induce physiologic responses, leading to physical symptoms and disease. In some cases, the impacts of psychological stress can result in the worsening of individuals' medical conditions.

According to epidemiological studies, chronic psychological stress can cause symptoms of anxiety and nervousness, panic attacks, physical sensations of anxiety, tendencies to predict the worst, conflict avoidance, muscle tension, tremors, headaches, and low/excessive motivation.


If you have experienced some of the above symptoms, you may have chronic psychological stress, please make sure you check with your doctor to rule out the possibility.


Some researchers suggested that psychological stress can increase or decrease the production of certain hormones, causing a significant change in one life physically and psychologically, if the change has become chronic.

Dr. Salam Ranabir, the lead scientist in examing the stress impacts on hormones, said, "In the modern environment one is exposed to various stressful conditions. Stress can lead to changes in the serum level of many hormones including glucocorticoids, catecholamines, growth hormone, and prolactin"

And, " Some of these changes are necessary for the fight or flight response to protect oneself. Some of these stress responses can lead to endocrine disorders like Graves’ disease, gonadal dysfunction, psychosexual dwarfism, and obesity. Stress can also alter the clinical status of many preexisting endocrine disorders such as precipitation of adrenal crisis and thyroid storm".

These results suggested clearly that people under long-term stress are susceptible to the onset of abnormal hormone-related diseases and syndromes.


Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding natural ingredients for the improvement of fat and glucose metabolism examined the effects of individual spice including ginger physiological responses to high-fat meals.

These results strongly suggested that a meal containing a high antioxidant spice blend attenuates postprandial lipemia by 30% compared to a low-spice meal through the influence of acute psychological stress on fat metabolism.

In the 2 x 2, randomized, 4-period crossover design in 20 healthy but overweight adults, researchers compared the effects of 14.5 g spices (black pepper, cinnamon, cloves, garlic, ginger, oregano, paprika, rosemary, and turmeric) vs. placebo incorporated into a high-fat meal (1000 kcal, 45 g fat), followed by psychological stress (Trier Social Stress Test) vs. rest on postprandial metabolism.

According to the blood sample collected at baseline and at 105, 140, 180, and 210 minutes for analysis of triglycerides, glucose, and insulin, the levels of serum triglycerides, glucose an,d insulin were elevated following the meal.

Application of spices, including ginger reduced post-meal triglycerides by 31% followed by the rest condition (p = 0.048), however, this effect was not presented during stress.

Furthermore, the significant increase in acute stress of the tested subjects also had a strong impact to negate the activity of spice on levels of glucose or insulin.

Moreover, The spice blend and several of the individual spices dose-dependently inhibited PL and PLA2activity in vitro.

Where Phospholipase (PL) and Phospholipase A2 (PLA) are associated with the development of stress and inflammation.

Dr. the lead scientist after taking into account co and confounders said, "Spices may attenuate postprandial lipemia via inhibition of PL and PLA2. However, the impact of psychological stress negates any influence of the spice blend on triglycerides, and further, increases blood glucose and insulin".

The finding strongly suggested ginger showed no effects in inhibiting triglycerides and modulating the levels of glucose and insulin in people who are under constant psychological stress.

Interestingly, in order to reveal more information about ginger against psychological stress, researchers evaluated the activity of 6-gingerol on C. elegans.

The bioactive compound 6-gingerol was isolated from the most active ethyl acetate soluble fraction of ginger and showed an elevated survival rate of worms against stressful environments including thermal, osmotic, and oxidative conditions.

The results were attributed to the 6-gingerol activity in the elevated antioxidant enzyme activities of C. elegans, in the reduction of intracellular reactive oxygen species (ROS) accumulation in worms in a dose-dependent manner.


More importantly, the injection of 6-gingerol demonstrated that the increased stress tolerance of 6-gingerol-mediated worms could result from the promotion of stress resistance proteins such as heat shock protein (HSP-16.2) and superoxide dismutase (SOD-3).


Taken together, ginger exerted significant antioxidative stress through its bioactive compound compared to no effects in modulating triglycerides, blood glucose, and insulin if a person is under acute psychological stress.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Longevity and Stress Resistant Property of 6-Gingerol from Zingiber officinale Roscoe in Caenorhabditis elegans by Eun Byeol Lee,1 Jun Hyeong Kim,1 Chang Wan An,1 Yeong Jee Kim,1 Yun Jeong Noh,1Su Jin Kim,1 Ju-Eun Kim,1 Abinash Chandra Shrestha,1 Ha-Neul Ham,1 Jae-Yoon Leem,1Hyung-Kwon Jo,2 Dae-Sung Kim,2 Kwang Hyun Moon,3 Jeong Ho Lee,3 Kyung Ok Jeong,3 and Dae Keun Kim. (PubMed)
(2) Effects of culinary spices and psychological stress on postprandial lipemia and lipase activity: results of a randomized crossover study and in vitro experiments by Cindy E McCrea, Sheila G West, Penny M Kris-Etherton, Joshua D Lambert, Trent L Gaugler, Danette L Teeter, Katherine A Sauder, Yeyi Gu, Shannon L Glisan, and Ann C Skulas-Ray. (PMC)
(3) Stress and hormones by Salam Ranabir and K. Reetu. (PMC)

n-butylphthalide (NBP) Found in #Celery Processes Anti Hypertensive Activities, Researchers Suggest

Kyle J. Norton

Celery, the tasty vegetable may be used for the prevention and treatment of hypertension, some scientists suggested.
Hypertension is the most common syndrome in the Western world caused by abnormally high blood pressure.

Celery is a species of Apium graveolens, belonging to the family Apiaceae. It is cultivated all around the globe as a vegetable.

The veggie can grow to 1/2 m tall with stalks (leaf on the top) arranged in a conical shape joined at a common base.

There is no single cause of hypertension. Epidemiological studies suggested an unhealthy lifestyle such as a diet with high saturated and trans fat, red meat and processed food, and low fruits and vegetables, smoking, being overweight and obesity contribute to the onset of hypertension.

In the differentiation of the correlation between the Western diet which had been promoted by the industries over the last many decades and the risk of hypertension, researchers indicated, the Western diet is one of the major culprits associated with the rise of high blood pressure incidence in the adults of the Western world.

In other words, if you follow the Western diet, you will have chronic high blood pressure developed in some point during your lifetime. Luckily, if you make a change to a healthy diet, your risk of high blood pressure is reduced.

Dr. Hojhabrimanesh A, the lead scientist in the metabolic team at the Shiraz University of Medical Sciences in the classification of dietary risk of hypertension wrote, "Three major dietary patterns were identified, among which only the Western pattern (abundant in soft drinks, sweets and desserts, salt, mayonnaise, tea and coffee, salty snacks, high-fat dairy products, French fries, and red or processed meats) had a significant association with BP".


And " After adjusting for potential confounders in the analysis of covariance models, multivariable-adjusted means of the systolic and mean BP of subjects in the highest tertile of the Western pattern score were significantly higher than those in the lowest tertile".

With an aim to find a natural ingredient or whole food for the prevention and treatment of hypertension, researchers at the Mashhad University of Medical Sciences assessed the effects of different celery (Apium graveolens) seed extracts on blood pressure (BP).

In animal studies, elected rats were induced hypertension by the injection of deoxycorticosterone acetate.

The hexanic, methanolic, and aqueous-ethanolic extracts were administered intraperitoneally to examine the tested animal antihypertensive effects on BP and heart rate (HR), compared to the spironolactone as a diuretic and positive control.

The application of all extracts decreased BP and increased HR in hypertensive rats, with no effect on normotensive rats.

In volume analysis, administration of 300 mg/kg of hexanic, methanolic, and aqueous-ethanolic (20/80, v/v) extracts of the celery seed caused 38, 24, and 23 mmHg reduction in BP and 60, 25, and 27 beats per minute increase in the HR, respectively.

The effects of celery seed extracted were found to process high amounts of n-butylphthalide (NBP), which has been proven epidemiologically an antihypertensive constituent.

According to the HPLC, analysis data revealed that the hexanic extract demonstrated the greatest effect in normalizing the high blood pressure due to containing 3.7 and 4 times NBP greater than that of the methanolic and aqueous-ethanolic extracts.

Dr. Moghadam MH, the lead scientist wrote in the final report, " celery seed extracts have antihypertensive properties, which appears to be attributable to the actions of its active hydrophobic constitutes such as NBP" and, "can be considered an antihypertensive agent in the chronic treatment of elevated BP".

Additionally, in the study to evaluate the inverse associations of overall vegetable intake to blood pressure (BP); whether such relations prevail for both raw and cooked vegetables, researchers launched a review of the report of the cross-sectional associations of vegetable intakes with BP for 2195 Americans ages 40-59 in the International Study of Macro/Micronutrients and Blood Pressure (INTERMAP).

According to the multiple linear regression assay, intakes of both total raw and total cooked vegetables considered separately were inversely related to BP in multivariate-adjusted models.

There is no difference between commonly consumed individual raw and cooked vegetables in reducing high blood pressure, particularly in cooked celery.

Taken altogether, celery, cooked or raw processed high amounts of n-butylphthalide (NBP) is considered a functional food for the prevention and treatment of high blood pressure with no side effects.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(2) Relations of raw and cooked vegetable consumption to blood pressure: the INTERMAP Study by Chan Q1, Stamler J, Brown IJ, Daviglus ML, Van Horn L, Dyer AR, Oude Griep LM, Miura K, Ueshima H, Zhao L, Nicholson JK, Holmes E, Elliott P(PubMed)
(3) Antihypertensive effect of celery seed on rat blood pressure in chronic administration by Moghadam MH1, Imenshahidi M, Mohajeri SA.(PubMed)
(4) A Western dietary pattern is associated with higher blood pressure in Iranian adolescents by Hojhabrimanesh A1, Akhlaghi M1,2, Rahmani E2, Amanat S2, Atefi M2, Najafi M2, Hashemzadeh M2, Salehi S2, Faghih S. (PubMed)

#Honey Reduces Pain Involving the Pain Transmission Pathways, Researchers Find

Kyle J. Norton

Pain relief is an action to remove pain, distress, and oppression by blocking the pain-transmitting information from nerve cells to the brain neurons.
Acute pain is any pain that lasts less than 6 months. Most cases of acute pain are due to physical damage such as soft tissue damage of a sprained ankle or a paper cut. Acute pain is relatively sharper and more severe.

On the other hand, there are many risk factors associated with chronic pain. Some chronic pains can be caused by single factors such as diseases involving nerve damage to injuries that fail to heal properly. Others may be results from several factors including diseases associated with normal aging.

Over-the-counter medications used for the treatment of pain include acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs).

Besides the gastrointestinal discomforts, long-term use of Tylenol may be additive. Overdoses or consumed together with alcohol, Tylenol can cause liver damage in severe cases.

If you are taking some counter medicine for pain relief, please make sure you know all the side effects of the preventive measure.

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one healthy sweet food for replacing the use of white sugar and artificial sweetener many people.

Researchers on finding a natural ingredient for pain relief examined the honey effect as an adjunct pain therapy.

The pain relief of honey was the result of the contribution of the numerous phytochemicals and components, including the interaction of protein, amino acid, flavonoids, phenolics, organic acid, pigment, water, and (high) sugar content in honey.

These components work together to relieve pain by exerting antibacterial, antiinflammation, and immunomodulation properties.
\
According to additional differentiation, honey reduced pain through the expression of the level of the central and peripheral nervous system or at the autonomic receptor sites involved in pain transmission via the cyclooxygenase pathway in nociception and pain.

Futhermore, in the examined the honey pain relief in post-tonsillectomy treatment with or without adenoidectomy, researchers launched a randomized, double-blind, placebo-controlled study that included 140 patients, who were older than eight.

Patients were divided into two equal groups, honey, and placebo.

Compared the acetaminophen plus honey for the honey group, and acetaminophen plus placebo for the placebo group, researchers found that
* According to the visual analog scale (VAS) and the number of painkillers taken within the first three postoperative days, acetaminophen and acetaminophen plus honey groups showed a statistically significant reduction of pain.

*The reduced use of painkillers differed significantly every five postoperative days.

* Pain awoke at night is also reduced with no difference between groups.

* Honey injection exerted negligible side effects

These results strongly showed that postoperative honey administration reduces postoperative pain and analgesic requirements in patients after tonsillectomy.

Taken together, there is no doubt that honey may be considered a functional remedy for pain relief with few side effects, pending the confirmation of a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Chapter 10 - Honey—A Natural Remedy for Pain Relief by Author links open overlay panelN.M.LazimA.Baharudin. (PubMed)
(2) Post Tonsillectomy Pain: Can Honey Reduce the Analgesic Requirements? by Peyman Boroumand,1 Mohammad Mahdi Zamani,2 Masoumeh Saeedi,1Omid Rouhbakhshfar,1 Seyed Reza Hosseini Motlagh,1 and Fatemeh Aarabi Moghaddam. (PubMed)