Kyle J. Norton
Scientists may have found a kitchen spice which processes the potential to treat colon cancer, according to studies.
Colon cancer is a medicinal condition associated with irregular cell growth in the colon tissues.
According to the statistics provided by Stat-Canada, 1 in 16 Canadian men and 1 in 18 women will develop colorectal cancer over their lifetime. Cancer is the third leading cause of death behind prostate and lung cancer.
Every year, approximately 26,,000 Canadians are diagnosed with colorectal cancer, representing 13% of all new cancer cases.
Colon cancer is a slow-growth cancer, therefore, most colon cancer is detected in the later stage after experiencing symptoms of blood in your stool or an ongoing change in bowel habits. In other words, only 39% of colorectal cancer is detected in the early stage.
The 5-year survival rate of localized-stage colorectal cancer is 90%.
The cause of colon cancer is a result of the alternation of cell DNA. Researchers do not why? people with the same health conditions and family history, some are susceptible to the onset of the disease, while others do not.
Although there are many factors associated with the onset of colon cancer, aging may be one of the most prevalent risks. It probably is due to the disease patients over 10 to 15 years before the patients experience some related symptoms. In other words, according to epidemiological studies, the majority of colorectal cancers occur in people older than 50.
taking
"70% of colorectal cancer is diagnosed in patients over 65. Evaluation of the influence of age and comorbidity on survival and cause of death in a non-selected population".
And, "In colon cancer patient age and comorbidity predict survival. This represents possible bias or a reduced survival benefit of treatment, and is an indication that colon cancer is not the prognosis-defining illness in the majority of patients".
The result strongly suggested that colon cancer affects mostly the aging population over 65 years of age. The simultaneous presence of two chronic diseases or conditions in elderly patients is associated with a poor survival rate.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers in the finding of a bioactive compound to replace the chemo medication which induces serious side effects in cancer patients examined 6-Gingerol, a natural component of ginger, anti-colon cancer activity.
Injection of 6-gingerol treatment significantly reduced the cell viability of human colon cancer cell, LoVo, in a dose-dependent manner.
Furthermore, 6-gingerol induced significant G2/M phase arrest and had a slight influence on the sub-G1 phase in LoVo cells, according to the flow cytometric analysis and observed by the reduced levels of a protein involved cancer cell cycle.
Moreover, 6-gingerol also induced cancer cell apoptosis by elevating the functions of levels of tumor suppressive genes and exhibiting cytotoxicity through elevated intracellular reactive oxygen species (ROS).
These results strongly suggested 6-gingerol should be beneficial to the treatment of colon cancer, according to Dr. Lin CB and colleagues.
In order to understand more about the effect of ginger on colon cancer, researchers investigated a novel prodrug of aspirin, [6]-gingerol aspirinate (GAS) against colon cancer.
GAS exerted enhanced anti-cancer properties in vitro and superior gastroprotective effects in mice. by suppressing the enzymes involved mediation of tumor repopulation.
Importantly, GAS was also able to survive stomach acid and decomposed in intestinal linings or after absorption simultaneously release ASA and [6]-gingerol.
Dr. Yingdong Zhu, the lead scientist said in the final report, "Our results demonstrate the enhanced anticancer properties along with gastroprotective effects of GAS, suggesting that GAS can be a therapeutic equivalent for ASA in inflammatory and proliferative diseases without the deleterious effects on stomach mucosa".
Taken altogether, ginger processed as a highly active bio-compound may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of colon cancer with no side effects, pending the confirmation of a large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To ProfessionalNorton's Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) 6-Gingerol Inhibits Growth of Colon Cancer Cell LoVo via Induction of G2/M Arrest by Lin CB1, Lin CC, Tsay GJ.(PubMed)
(2) Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer by Yingdong Zhu, Fang Wang, Yantao Zhao, Pei Wang & Shengmin Sang. (Scientific Report)
(3) Impact of age and comorbidity on survival in colorectal cancer by Elmer E. van Eeghen, Sandra D. Bakker, Aart van Bochove, and Ruud J. L. F. Loffeld. (PMC)
Saturday, 24 June 2023
#Phytochemical #Betacyanins Found in #Beetroots Exihibit a Strong Activity Against the Risk of #BladderCancer, Researchers Show
Kyle J. Norton
The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.
Bladder cancer is the most common type of cancer that affects men twice as frequently as it affects women. Usually, bladder cancer starts from cells on the surface of the inner lining of the bladder caused by several types of malignant growths of the urinary bladder cells.
Depending on the cancer cell originated bladder cancer can be classified into
* Transitional cell carcinoma
Transitional cell carcinoma starts on the innermost tissue layer of the bladder. More than 90 percent of bladder cancers begin in the transitional cells
* Squamous cell carcinoma
Cancer begins in squamous cells found in the tissues of the surface of the bladder, due to long-term infection or irritation. About 8 percent of people with bladder cancers begin with squamous cells.
* Adenocarcinoma
Cancer begins originates in glandular tissue of the bladder, including the surface layer of skin, glands, and a variety of other tissue, due to long-term irritation and inflammation. Only 2 percent of people with the condition have a third bladder cancer type.
According to the statistics, most cases (90%) of bladder cancer are diagnosed in people older than 55, and the average age people are diagnosed with bladder cancer is 73 worldwide.
Believe it or not, bladder cancer will cause the death of 12,870 in men and 4,800 in women. Among men, bladder cancer is the eighth most common cause of cancer death.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With the aim to find a potential compound for the treatment of bladder cancer, researchers examined the effect of betacyanins (BC) purified from beetroot (Beta vulgaris var. Rubra L.) alone or in combination with vitexin-2-O-xyloside (XVX) from Beta vulgaris var. cicla L.on T24 bladder cancer cells.
According to the tested differentiation, the combination of BC and XVX exhibited a synergistic effect on the inhibition of proliferation in T24 cancer cells at 24 and 48 h but not after 72 h of incubation.
Furthermore, according to the observation of the means of fluorescence-activated cell sorting (FACS) analysis, the combined treatment induced cancer cell apoptosis by activating the protein associated with cell death signaling.
In cell death analysis, the combination promoted the expression of genes involved in pro-apoptosis and inhibited the genes associated with anti-apoptosis in bladder cancer cell lines.
Moreover, the combined treatment also demonstrated strong activity in the induction of cytotoxicity against bladder cancer cells without affecting the normal human skin NCTC 2544 keratinocytes.
Based on the finding, Dr. Emanuele Salvatore Scarpa, the lead scientist wrote, "These results demonstrated the efficacy and the mechanisms of the action of BC and XVX, extracted from edible plants, and suggested that a diet or a nutrition supplement, enriched with these bioactive molecules, could be used in the prevention of human bladder cancer".
Taken together, betacyanins used alone or combined with herbal remedy may be considered a remedy for the prevention and treatment of bladder cancer, pending remedies the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betacyanins enhance vitexin-2-O-xyloside mediated inhibition of proliferation of T24 bladder cancer cells by Emanuele Salvatore Scarpa, Monica Emanuelli, Alessandra Frati, and Valentina Pozzi (Research Gate)
(2) Bladder Cancer by Kyle J. Norton
The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.
Bladder cancer is the most common type of cancer that affects men twice as frequently as it affects women. Usually, bladder cancer starts from cells on the surface of the inner lining of the bladder caused by several types of malignant growths of the urinary bladder cells.
Depending on the cancer cell originated bladder cancer can be classified into
* Transitional cell carcinoma
Transitional cell carcinoma starts on the innermost tissue layer of the bladder. More than 90 percent of bladder cancers begin in the transitional cells
* Squamous cell carcinoma
Cancer begins in squamous cells found in the tissues of the surface of the bladder, due to long-term infection or irritation. About 8 percent of people with bladder cancers begin with squamous cells.
* Adenocarcinoma
Cancer begins originates in glandular tissue of the bladder, including the surface layer of skin, glands, and a variety of other tissue, due to long-term irritation and inflammation. Only 2 percent of people with the condition have a third bladder cancer type.
According to the statistics, most cases (90%) of bladder cancer are diagnosed in people older than 55, and the average age people are diagnosed with bladder cancer is 73 worldwide.
Believe it or not, bladder cancer will cause the death of 12,870 in men and 4,800 in women. Among men, bladder cancer is the eighth most common cause of cancer death.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With the aim to find a potential compound for the treatment of bladder cancer, researchers examined the effect of betacyanins (BC) purified from beetroot (Beta vulgaris var. Rubra L.) alone or in combination with vitexin-2-O-xyloside (XVX) from Beta vulgaris var. cicla L.on T24 bladder cancer cells.
According to the tested differentiation, the combination of BC and XVX exhibited a synergistic effect on the inhibition of proliferation in T24 cancer cells at 24 and 48 h but not after 72 h of incubation.
Furthermore, according to the observation of the means of fluorescence-activated cell sorting (FACS) analysis, the combined treatment induced cancer cell apoptosis by activating the protein associated with cell death signaling.
In cell death analysis, the combination promoted the expression of genes involved in pro-apoptosis and inhibited the genes associated with anti-apoptosis in bladder cancer cell lines.
Moreover, the combined treatment also demonstrated strong activity in the induction of cytotoxicity against bladder cancer cells without affecting the normal human skin NCTC 2544 keratinocytes.
Based on the finding, Dr. Emanuele Salvatore Scarpa, the lead scientist wrote, "These results demonstrated the efficacy and the mechanisms of the action of BC and XVX, extracted from edible plants, and suggested that a diet or a nutrition supplement, enriched with these bioactive molecules, could be used in the prevention of human bladder cancer".
Taken together, betacyanins used alone or combined with herbal remedy may be considered a remedy for the prevention and treatment of bladder cancer, pending remedies the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betacyanins enhance vitexin-2-O-xyloside mediated inhibition of proliferation of T24 bladder cancer cells by Emanuele Salvatore Scarpa, Monica Emanuelli, Alessandra Frati, and Valentina Pozzi (Research Gate)
(2) Bladder Cancer by Kyle J. Norton
#Healthyfood #NavyBean, Lentils & Chickpea Pulse Powders Show A Significant Effect on Modulating the #PostprandialGlycemicResponse, Researchers Say
Kyle J. Norton
Diabetes is a chronic disease associated with insufficient insulin entering the bloodstream to regulate the glucose caused by either the cells in the pancreas died-off or receptor sites clogged up by fat and cholesterol. Hyperglycemia is a condition of abnormally high levels of glucose in the bloodstream.
Glycemic response is a change in blood glucose after consuming a carbohydrate-containing food compared to Glycemic Index (GI) which ranks carbohydrate-containing foods according to their effect on blood glucose levels.
In other words, the glycemic response is the change of blood glucose after the intake of a food or meal.
Postprandial blood glucose is the level taken after 2 hours of a meal, generally at the approximate peak value in patients with diabetes.
According to the 2015 statistics by the American Diabetes Association, in the U.S. over 30.3 million Americans, or 9.4% of the population are living with diabetes. Sadly, out of 30.3 million adults with diabetes, 23.1 million were diagnosed, and 7.2 million were undiagnosed.
Believe it or not, in 2015, 84.1 million Americans age 18 and older had prediabetes.
Most people who are not prediabetes or diabetes have normal blood glucose and insulin levels that rise within the range after eating, then return to the fasting levels over a short period of time.
According to epidemiological studies, by controlling the glycaemic response within the healthy range, the glycaemic response can reduce the risk of type 2 diabetes. Some researchers suggested including additional fibers into a meal or food can reduce the levels of glucose shortly after intake.
By managing postprandial blood glucose effectively, diabetics can decrease the risk of microvascular (retinopathy, nephropathy, and neuropathy) and cardiovascular disease (CVD).
The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.
With an aim to find a potential compound for the improvement of postprandial glycaemic response, researchers examined the effect of dietary take of pulses, including navy bean.
The study included healthy young men received commercially prepared pulse powders and BG response was recorded before and after a subsequent meal.
More precisely, participants were randomly divided into whole, puréed and powdered pulses (navy beans in Expt 1; lentils in Expt 2; chickpeas in Expt 3) and whole-wheat flour as the control.
After a fixed-energy pizza meal (50·2 kJ/kg body weight) was provided at 120 min, the BG concentration was measured before (0-120 min) and after (140-200 min) the pizza meal, researchers found that
* Compared with the whole-wheat flour control, navy bean treatments lowered peak BG concentrations but not the mean BG concentration over 120 min.
* Compared to navy bean, all lentils and chickpeas lower the mean BG concentration over 120 min after treatments
* Moreover, processing pulses to powdered form does not eliminate the benefits of whole pulses on BG response.
Based on the finding, researchers said, "the use of pulse powders as value-added food ingredients to moderate postprandial glycaemic response".
Taken together, Navy beans used alone or combined with conventional medicine may be considered a remedy for the improvement of postprandial glycaemic response, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The acute effect of commercially available pulse powders on postprandial glycaemic response in healthy young men by Anderson GH1, Liu Y1, Smith CE1, Liu TT1, Nunez MF1, Mollard RC1, Luhovyy BL. (PubMed)
(2) First and second meal effects of pulses on blood glucose, appetite, and food intake at a later meal by Mollard RC1, Wong CL, Luhovyy BL, Anderson GH. (PubMed)
Diabetes is a chronic disease associated with insufficient insulin entering the bloodstream to regulate the glucose caused by either the cells in the pancreas died-off or receptor sites clogged up by fat and cholesterol. Hyperglycemia is a condition of abnormally high levels of glucose in the bloodstream.
Glycemic response is a change in blood glucose after consuming a carbohydrate-containing food compared to Glycemic Index (GI) which ranks carbohydrate-containing foods according to their effect on blood glucose levels.
In other words, the glycemic response is the change of blood glucose after the intake of a food or meal.
Postprandial blood glucose is the level taken after 2 hours of a meal, generally at the approximate peak value in patients with diabetes.
According to the 2015 statistics by the American Diabetes Association, in the U.S. over 30.3 million Americans, or 9.4% of the population are living with diabetes. Sadly, out of 30.3 million adults with diabetes, 23.1 million were diagnosed, and 7.2 million were undiagnosed.
Believe it or not, in 2015, 84.1 million Americans age 18 and older had prediabetes.
Most people who are not prediabetes or diabetes have normal blood glucose and insulin levels that rise within the range after eating, then return to the fasting levels over a short period of time.
According to epidemiological studies, by controlling the glycaemic response within the healthy range, the glycaemic response can reduce the risk of type 2 diabetes. Some researchers suggested including additional fibers into a meal or food can reduce the levels of glucose shortly after intake.
By managing postprandial blood glucose effectively, diabetics can decrease the risk of microvascular (retinopathy, nephropathy, and neuropathy) and cardiovascular disease (CVD).
The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.
With an aim to find a potential compound for the improvement of postprandial glycaemic response, researchers examined the effect of dietary take of pulses, including navy bean.
The study included healthy young men received commercially prepared pulse powders and BG response was recorded before and after a subsequent meal.
More precisely, participants were randomly divided into whole, puréed and powdered pulses (navy beans in Expt 1; lentils in Expt 2; chickpeas in Expt 3) and whole-wheat flour as the control.
After a fixed-energy pizza meal (50·2 kJ/kg body weight) was provided at 120 min, the BG concentration was measured before (0-120 min) and after (140-200 min) the pizza meal, researchers found that
* Compared with the whole-wheat flour control, navy bean treatments lowered peak BG concentrations but not the mean BG concentration over 120 min.
* Compared to navy bean, all lentils and chickpeas lower the mean BG concentration over 120 min after treatments
* Moreover, processing pulses to powdered form does not eliminate the benefits of whole pulses on BG response.
Based on the finding, researchers said, "the use of pulse powders as value-added food ingredients to moderate postprandial glycaemic response".
Taken together, Navy beans used alone or combined with conventional medicine may be considered a remedy for the improvement of postprandial glycaemic response, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The acute effect of commercially available pulse powders on postprandial glycaemic response in healthy young men by Anderson GH1, Liu Y1, Smith CE1, Liu TT1, Nunez MF1, Mollard RC1, Luhovyy BL. (PubMed)
(2) First and second meal effects of pulses on blood glucose, appetite, and food intake at a later meal by Mollard RC1, Wong CL, Luhovyy BL, Anderson GH. (PubMed)
#Phytochemical #Alliin Protects the Heart Against Cardiotoxicity Induced by Chemotherapy by Doxorubicin (Adriamycin) in Vivo
Kyle J. Norton
Cardiotoxicity is a condition caused by toxins accumulated in the heart that leads to damage to the heart muscle.
Cardiotoxicity reduced the heart's pumping blood capability, leading to a decrease in oxygen-rich blood to nourish the body tissues and organs.
The most common symptoms of cardiotoxicity, are tiredness fatigue, chronic cough, water retention, and shortness of breath.
If you have experienced some of the aforementioned symptoms that can be healed within a week or 2, please check with your doctor to rule out the possibility.
The most common causes of cardiotoxicity are associated with patients receiving chemotherapy and intake of certain medications. However, infection, excessive alcohol consumption, medical conditions such as diabetes and thyroid disease, high blood pressure, and thiamine and Vitamin B deficiency have also been found to induce cardiotoxicity.
Some researchers suggested that the promotion of a high-fat diet over the past few decades that facilitate widespread obesity may increase the cardiotoxicity risk of obese who are treated by chemotherapy.
Dr. Mitra MS, the lead scientist said, "Often, chemotherapy by doxorubicin (Adriamycin) is limited due to life-threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity".
And, "HFD-induced obese rats are highly sensitized to doxorubicin-induced cardiotoxicity".
In other words, non-obese patients who follow the recommended diet before taking chemotherapy for the treatment of cancer are less sensitive to doxorubicin-induced cardiotoxicity compared to a high-fat diet obese.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential compound with cardioprotective activity, researchers examined the effect of S-allyl cysteine sulphoxide (SACS) in isoproterenol (ISO)-induced cardiotoxicity in male Wistar rats.
The study included myocardial infarction induced by subcutaneous injection of ISO (150 mg/kg) once a day for 2 days followed by SACS (40 and 80 mg/kg) as pretreatment orally daily for a period of 35 days using an intragastric tube.
SACS pretreatment showed significantly lowered levels of free radicals and increased antioxidant activities of mitochondrial superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST), and glutathione (GSH).
Furthermore, SACS pretreatment not only decreased the levels of mitochondrial cholesterol, free fatty acids (FFAs), triglycerides (TGs), and calcium, associated with plaque accumulation and the activity of xanthine oxidase (XOD) involved the production of the free radicals in the heart but also increased significantly the levels of mitochondrial phospholipids of the inner membrane of the heart against damage.
Moreover, pretreatment of SACS also protected the heart mitochondrial fraction by increasing the activities of isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), alpha-ketoglutarate dehydrogenase (alpha-KGDH), NADH-dehydrogenase, and cytochrome C-oxidase.
Interestingly, oral administration of SACS for a period of 35 days showed no cardio effect in normal control rats.
In other words, SACS modulated heart function against mitochondrial cardiotoxicity without affecting the heart function in healthy control.
Based on the findings researchers said, "The effect at a dose of SACS 80 mg/kg was more effective than the dose 40 mg/kg. The results of the study conclude that SACS protect the mitochondria of the ISO-induced myocardial-infarcted rats".
In order to know more information about SACS cardioprotective activity, researchers examined the preventive role of SACS on glycoproteins and hematology in experimentally induced myocardial infarction in rats for 2 days.
Injection of SACS restored the abnormally significant increase in the levels of serum iron, uric acid and blood glucose, Na(+) and Ca(2+) characterized by heart damage and elevated blood glucose.
Furthermore, the significant decrease in the levels of plasma iron binding capacity, serum total protein, albumin/globulin ratio, heart K(+), and heart glycogen induced by isoproterenol (ISO) associated with heart tissues damage were also inhibited by the treatment of SACS in myocardial infarcted rats.
Moreover, SACS also modulated the immune response in the production of pro-inflammatory cytokines induced by isoproterenol (ISO) toxicity.
Additional differentiation of the results suggested that oral pretreatment with SACS (40 and 80 mg kg(-1)) daily for a period of 35 days prevents cardiotoxicity by improving all the biochemical parameters studied in ISO-induced rats.
Taken altogether, alliin may be considered a supplement for the prevention and treatment of cardiotoxicity, depending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Preventive effect of S-allyl cysteine sulphoxide (Alliin) on mitochondrial dysfunction in normal and isoproterenol-induced cardiotoxicity in male Wistar rats: a histopathological study by Sangeetha T1, Darlin Quine S. (PubMed)
(2) Protective effect of S-allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol-induced myocardial infarction in male Wistar rats by Sangeetha T1, Quine SD. (PubMed)
(3) High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity by Mitra MS1, Donthamsetty S, White B, Mehendale HM. (PubMed)
Cardiotoxicity is a condition caused by toxins accumulated in the heart that leads to damage to the heart muscle.
Cardiotoxicity reduced the heart's pumping blood capability, leading to a decrease in oxygen-rich blood to nourish the body tissues and organs.
The most common symptoms of cardiotoxicity, are tiredness fatigue, chronic cough, water retention, and shortness of breath.
If you have experienced some of the aforementioned symptoms that can be healed within a week or 2, please check with your doctor to rule out the possibility.
The most common causes of cardiotoxicity are associated with patients receiving chemotherapy and intake of certain medications. However, infection, excessive alcohol consumption, medical conditions such as diabetes and thyroid disease, high blood pressure, and thiamine and Vitamin B deficiency have also been found to induce cardiotoxicity.
Some researchers suggested that the promotion of a high-fat diet over the past few decades that facilitate widespread obesity may increase the cardiotoxicity risk of obese who are treated by chemotherapy.
Dr. Mitra MS, the lead scientist said, "Often, chemotherapy by doxorubicin (Adriamycin) is limited due to life-threatening cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity".
And, "HFD-induced obese rats are highly sensitized to doxorubicin-induced cardiotoxicity".
In other words, non-obese patients who follow the recommended diet before taking chemotherapy for the treatment of cancer are less sensitive to doxorubicin-induced cardiotoxicity compared to a high-fat diet obese.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential compound with cardioprotective activity, researchers examined the effect of S-allyl cysteine sulphoxide (SACS) in isoproterenol (ISO)-induced cardiotoxicity in male Wistar rats.
The study included myocardial infarction induced by subcutaneous injection of ISO (150 mg/kg) once a day for 2 days followed by SACS (40 and 80 mg/kg) as pretreatment orally daily for a period of 35 days using an intragastric tube.
SACS pretreatment showed significantly lowered levels of free radicals and increased antioxidant activities of mitochondrial superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST), and glutathione (GSH).
Furthermore, SACS pretreatment not only decreased the levels of mitochondrial cholesterol, free fatty acids (FFAs), triglycerides (TGs), and calcium, associated with plaque accumulation and the activity of xanthine oxidase (XOD) involved the production of the free radicals in the heart but also increased significantly the levels of mitochondrial phospholipids of the inner membrane of the heart against damage.
Moreover, pretreatment of SACS also protected the heart mitochondrial fraction by increasing the activities of isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), alpha-ketoglutarate dehydrogenase (alpha-KGDH), NADH-dehydrogenase, and cytochrome C-oxidase.
Interestingly, oral administration of SACS for a period of 35 days showed no cardio effect in normal control rats.
In other words, SACS modulated heart function against mitochondrial cardiotoxicity without affecting the heart function in healthy control.
Based on the findings researchers said, "The effect at a dose of SACS 80 mg/kg was more effective than the dose 40 mg/kg. The results of the study conclude that SACS protect the mitochondria of the ISO-induced myocardial-infarcted rats".
In order to know more information about SACS cardioprotective activity, researchers examined the preventive role of SACS on glycoproteins and hematology in experimentally induced myocardial infarction in rats for 2 days.
Injection of SACS restored the abnormally significant increase in the levels of serum iron, uric acid and blood glucose, Na(+) and Ca(2+) characterized by heart damage and elevated blood glucose.
Furthermore, the significant decrease in the levels of plasma iron binding capacity, serum total protein, albumin/globulin ratio, heart K(+), and heart glycogen induced by isoproterenol (ISO) associated with heart tissues damage were also inhibited by the treatment of SACS in myocardial infarcted rats.
Moreover, SACS also modulated the immune response in the production of pro-inflammatory cytokines induced by isoproterenol (ISO) toxicity.
Additional differentiation of the results suggested that oral pretreatment with SACS (40 and 80 mg kg(-1)) daily for a period of 35 days prevents cardiotoxicity by improving all the biochemical parameters studied in ISO-induced rats.
Taken altogether, alliin may be considered a supplement for the prevention and treatment of cardiotoxicity, depending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Preventive effect of S-allyl cysteine sulphoxide (Alliin) on mitochondrial dysfunction in normal and isoproterenol-induced cardiotoxicity in male Wistar rats: a histopathological study by Sangeetha T1, Darlin Quine S. (PubMed)
(2) Protective effect of S-allyl cysteine sulphoxide (alliin) on glycoproteins and hematology in isoproterenol-induced myocardial infarction in male Wistar rats by Sangeetha T1, Quine SD. (PubMed)
(3) High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity by Mitra MS1, Donthamsetty S, White B, Mehendale HM. (PubMed)
#HathaYoga Intrevention Inhibits the Psychological, and Urogenital Menopausal Symptoms in Clinical Trials
Kyle J. Norton
A recent study conducted by a renowned institute suggested that yoga therapy can enhance the quality of life and alleviate menopausal symptoms.
Menopause is the transition stage of permanent cessation of the ovary's functions in egg production inducing less production of estrogen and progesterone, signaling the end of the reproductive phase of a woman's life. In perimenopause, menstruation has become irregular and slowly stops over time, but in some women, menstrual flow may come to a sudden halt phase.
A recent study conducted by a renowned institute suggested that yoga therapy can enhance the quality of life and alleviate menopausal symptoms.
Menopause is the transition stage of permanent cessation of the ovary's functions in egg production inducing less production of estrogen and progesterone, signaling the end of the reproductive phase of a woman's life. In perimenopause, menstruation has become irregular and slowly stops over time, but in some women, menstrual flow may come to a sudden halt phase.
Yoga, the ancient technique practice for harmonized external and internal body well-being, through breath control, meditation, bodily movement, and gesture..... has been well-known for people in the Western world and some parts of Asia due to health benefits reported by various respectable institutes research and supported by health advocates.
In a secondary analysis of a randomized controlled trial comparing the effects of yoga with those of usual care in 40 breast cancer survivors suffering from menopausal symptoms, with all participants completed all 3 assessments (week 0, week 12, and week 24), yoga attendees scored a significant improvement of total menopausal symptoms, including psychological menopausal symptoms, and urogenital menopausal symptoms, as well as enhanced, quality of life, social well-being, emotional well-being, functional well-being, and fatigue in comparison to the control group.
Dr. Koch AK, the lead author said, "Self-esteem plays a vital role in the beneficial effect of yoga and that yoga can have long-term benefits for women diagnosed with breast cancer and undergoing menopausal transition".
Furthermore, in the compared study to test the effects of a 12-week traditional Hatha yoga and meditation intervention on menopausal symptoms in breast cancer survivors, yoga and meditation intervention expresses a significant improvement in lower total menopausal symptoms compared with the usual care group at week 12 (mean difference, -5.6; 95% confidence interval, -9.2 to -1.9; P = .004) and at week 24.
Additionally, the Yoga group also showed a remarkable benefit in less vegetative, psychological, and urogenital menopausal symptoms; less fatigue at week 12, particularly in short terms.
With the promising results, some researchers suggested that yoga can be considered a safe and effective alternative intervention in ameliorating menopausal symptoms with persistence, for at least 3 months.
In fact, yoga intervention also has positive and specific implications for menopausal symptoms frequency. According to the 37 disease-free women experiencing hot flashes randomized to the 8-week Yoga of Awareness program (gentle yoga poses, meditation, and breathing exercises) or to a wait-list control. yoga group expressed a significantly greater improvement relative to the control condition in hot-flash frequency, severity, and total scores and in levels of joint pain, fatigue, sleep disturbance, symptom-related bother, and vigor in post-treatment, compared to the control group.
More importantly, at 3 months follow-up, patients in the yoga group only maintained the improvement in hot flashes, joint pain, fatigue, symptom-related bother, and vigor but also showed additional significant gains in negative mood, relaxation, and acceptance as same in post-treatment.
Taken together, Participation in a yoga class may be one of the safe and effective interventions in attenuating menopause symptoms in many aspects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effects of yoga and self-esteem on menopausal symptoms and quality of life in breast cancer survivors-A secondary analysis of a randomized controlled trial by Koch AK1, Rabsilber S2, Lauche R3, Kümmel S4, Dobos G5, Langhorst J6, Cramer H3.(PubMed)
(2) Yoga and meditation for menopausal symptoms in breast cancer survivors-A randomized controlled trial by Cramer H1,2, Rabsilber S3,4, Lauche R1,2, Kümmel S4, Dobos G1(PubMed).
In a secondary analysis of a randomized controlled trial comparing the effects of yoga with those of usual care in 40 breast cancer survivors suffering from menopausal symptoms, with all participants completed all 3 assessments (week 0, week 12, and week 24), yoga attendees scored a significant improvement of total menopausal symptoms, including psychological menopausal symptoms, and urogenital menopausal symptoms, as well as enhanced, quality of life, social well-being, emotional well-being, functional well-being, and fatigue in comparison to the control group.
Dr. Koch AK, the lead author said, "Self-esteem plays a vital role in the beneficial effect of yoga and that yoga can have long-term benefits for women diagnosed with breast cancer and undergoing menopausal transition".
Furthermore, in the compared study to test the effects of a 12-week traditional Hatha yoga and meditation intervention on menopausal symptoms in breast cancer survivors, yoga and meditation intervention expresses a significant improvement in lower total menopausal symptoms compared with the usual care group at week 12 (mean difference, -5.6; 95% confidence interval, -9.2 to -1.9; P = .004) and at week 24.
Additionally, the Yoga group also showed a remarkable benefit in less vegetative, psychological, and urogenital menopausal symptoms; less fatigue at week 12, particularly in short terms.
With the promising results, some researchers suggested that yoga can be considered a safe and effective alternative intervention in ameliorating menopausal symptoms with persistence, for at least 3 months.
In fact, yoga intervention also has positive and specific implications for menopausal symptoms frequency. According to the 37 disease-free women experiencing hot flashes randomized to the 8-week Yoga of Awareness program (gentle yoga poses, meditation, and breathing exercises) or to a wait-list control. yoga group expressed a significantly greater improvement relative to the control condition in hot-flash frequency, severity, and total scores and in levels of joint pain, fatigue, sleep disturbance, symptom-related bother, and vigor in post-treatment, compared to the control group.
More importantly, at 3 months follow-up, patients in the yoga group only maintained the improvement in hot flashes, joint pain, fatigue, symptom-related bother, and vigor but also showed additional significant gains in negative mood, relaxation, and acceptance as same in post-treatment.
Taken together, Participation in a yoga class may be one of the safe and effective interventions in attenuating menopause symptoms in many aspects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effects of yoga and self-esteem on menopausal symptoms and quality of life in breast cancer survivors-A secondary analysis of a randomized controlled trial by Koch AK1, Rabsilber S2, Lauche R3, Kümmel S4, Dobos G5, Langhorst J6, Cramer H3.(PubMed)
(2) Yoga and meditation for menopausal symptoms in breast cancer survivors-A randomized controlled trial by Cramer H1,2, Rabsilber S3,4, Lauche R1,2, Kümmel S4, Dobos G1(PubMed).
#ManukaHoney Combined with Conventional Medicine Show a Strong Effect on #Influenza, Scientists Suggest
Kyle J. Norton
Scientists may have found a natural alternative for the treatment of Influenza, according to studies.Influenza, also known as the flu, is an infectious disease caused by an influenza virus.
The most common symptoms include high fever, runny nose, sore throat, muscle pains, headache, coughing, and sneezing. A healthy individual may recover from influenza without medication in a few days with the symptoms that may last for a week.
However, people with a weakened immune system may have a problem recovering themselves without the assistance of medication. In severe cases, influenza can induce complications of pneumonia, ear, and sinus infection, and death.
People with medical conditions such as heart, lung, kidney, liver disease, AIDs, severe anemia are at a higher risk of the onset of influenza, particularly in the elderly with a weakened immune system.
Children and adolescents who are receiving long-term aspirin therapy are at risk to be infected by the virus.
Furthermore, some researchers suggested that obese individuals also are more likely to be infected by influenza, compared to non-obese individuals.
Dr. J Justin Milner, the lead scientist in examining the obesity and influenza infection severity said, "Obesity also increases susceptibility to bacterial and viral infections [2]. In 2009, the CDC identified obesity as a risk factor for hospitalization and death from pandemic H1N1 influenza virus infection".
And, "An association between obesity and severe influenza outcomes, including seasonal influenza, has since been corroborated in other epidemiological studies".
The finding strongly indicated the risk of influenza in obesity.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered healthy sweet food for replacing the use of white sugar and artificial sweetener many people.
With an aim to find a natural whole food for the treatment of influenza, researchers examined the anti-influenza viral activity of honey from various sources.
Antiviral activities of honey samples were evaluated in MDCK cells. Injection of Manuka honey efficiently inhibited influenza virus replication (IC50 5 3.6 1.2 mg/mL; CC50 5 82.3 2.2 mg/mL; selective index 5 22.9).
Furthermore,. In the presence of 3.13 mg/mL manuka honey, the IC50 of zanamivir or oseltamivir was reduced to nearly 1/1000th of their single use.
The finding clearly suggested that Manuka honey processes a strong anti-influenza activity when used alone or by promoting the function of conventional medicine when used combinational.
Some researchers suggested that manuka also inhibited the symptoms of influenza such as blocked sinuses, sore throat, and coughs through its major compound Methylglyoxal (MGO).
Moreover, Manuka honey also inhibited the production of proinflammatory cytokines during the acute phase of influenza, thus providing instant relief fa or a sore throat and cough.
From an immune perspective, Manuka honey also increased the expression of serum immunoglobulin G (IgG) which plays a critical role against the onset of infection by microorganisms.
Dr. Ogi M, the lead scientist after taking into account co and confounders said, "The relative risk for bacterial infection among patients with serum immunoglobulin G (IgG) levels below 600 mg/dL was 6.74 compared with that for patients with serum IgG levels over 600 mg/dL (95% confidence interval, 1.22 to 36.32; P = 0.029)"
And "In patients with serum creatinine levels over 2.0 mg/dL, the relative risk of bacterial infection was 5.31 compared with patients with serum creatinine levels below 2.0 mg/dL (95% confidence interval, 1.08 to 26.09; P = 0.040)".
The finding also suggested that Manuka honey also can modulate immune expression to prevent the infection caused by the influenza virus by increased production of immunoglobulin G.
Taken all together, there is no doubt that Manuka honey can be considered a functional remedy for the prevention and treatment of influenza, pending the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Anti-influenza viral effects of honey in vitro: the potent high activity of manuka honey by Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N. (EL SEVIER)
(2) Manuka Honey the best Natural Cold and Flu Remedy By Mr. Vitamins
(3) Risk factors for infection and immunoglobulin replacement therapy in adult nephrotic syndrome by Ogi M1, Yokoyama H, Tomosugi N, Hisada Y, Ohta S, Takaeda M, Wada T, Naito T, Ikeda K, Goshima S. (PubMed)
(4) Obesity and influenza infection severity by J Justin Milner & Melinda A Beck. (Future Medicine)
Scientists may have found a natural alternative for the treatment of Influenza, according to studies.Influenza, also known as the flu, is an infectious disease caused by an influenza virus.
The most common symptoms include high fever, runny nose, sore throat, muscle pains, headache, coughing, and sneezing. A healthy individual may recover from influenza without medication in a few days with the symptoms that may last for a week.
However, people with a weakened immune system may have a problem recovering themselves without the assistance of medication. In severe cases, influenza can induce complications of pneumonia, ear, and sinus infection, and death.
People with medical conditions such as heart, lung, kidney, liver disease, AIDs, severe anemia are at a higher risk of the onset of influenza, particularly in the elderly with a weakened immune system.
Children and adolescents who are receiving long-term aspirin therapy are at risk to be infected by the virus.
Furthermore, some researchers suggested that obese individuals also are more likely to be infected by influenza, compared to non-obese individuals.
Dr. J Justin Milner, the lead scientist in examining the obesity and influenza infection severity said, "Obesity also increases susceptibility to bacterial and viral infections [2]. In 2009, the CDC identified obesity as a risk factor for hospitalization and death from pandemic H1N1 influenza virus infection".
And, "An association between obesity and severe influenza outcomes, including seasonal influenza, has since been corroborated in other epidemiological studies".
The finding strongly indicated the risk of influenza in obesity.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered healthy sweet food for replacing the use of white sugar and artificial sweetener many people.
With an aim to find a natural whole food for the treatment of influenza, researchers examined the anti-influenza viral activity of honey from various sources.
Antiviral activities of honey samples were evaluated in MDCK cells. Injection of Manuka honey efficiently inhibited influenza virus replication (IC50 5 3.6 1.2 mg/mL; CC50 5 82.3 2.2 mg/mL; selective index 5 22.9).
Furthermore,. In the presence of 3.13 mg/mL manuka honey, the IC50 of zanamivir or oseltamivir was reduced to nearly 1/1000th of their single use.
The finding clearly suggested that Manuka honey processes a strong anti-influenza activity when used alone or by promoting the function of conventional medicine when used combinational.
Some researchers suggested that manuka also inhibited the symptoms of influenza such as blocked sinuses, sore throat, and coughs through its major compound Methylglyoxal (MGO).
Moreover, Manuka honey also inhibited the production of proinflammatory cytokines during the acute phase of influenza, thus providing instant relief fa or a sore throat and cough.
From an immune perspective, Manuka honey also increased the expression of serum immunoglobulin G (IgG) which plays a critical role against the onset of infection by microorganisms.
Dr. Ogi M, the lead scientist after taking into account co and confounders said, "The relative risk for bacterial infection among patients with serum immunoglobulin G (IgG) levels below 600 mg/dL was 6.74 compared with that for patients with serum IgG levels over 600 mg/dL (95% confidence interval, 1.22 to 36.32; P = 0.029)"
And "In patients with serum creatinine levels over 2.0 mg/dL, the relative risk of bacterial infection was 5.31 compared with patients with serum creatinine levels below 2.0 mg/dL (95% confidence interval, 1.08 to 26.09; P = 0.040)".
The finding also suggested that Manuka honey also can modulate immune expression to prevent the infection caused by the influenza virus by increased production of immunoglobulin G.
Taken all together, there is no doubt that Manuka honey can be considered a functional remedy for the prevention and treatment of influenza, pending the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma ISSN 0975-6299.
Sources
(1) Anti-influenza viral effects of honey in vitro: the potent high activity of manuka honey by Watanabe K1, Rahmasari R1, Matsunaga A1, Haruyama T2, Kobayashi N. (EL SEVIER)
(2) Manuka Honey the best Natural Cold and Flu Remedy By Mr. Vitamins
(3) Risk factors for infection and immunoglobulin replacement therapy in adult nephrotic syndrome by Ogi M1, Yokoyama H, Tomosugi N, Hisada Y, Ohta S, Takaeda M, Wada T, Naito T, Ikeda K, Goshima S. (PubMed)
(4) Obesity and influenza infection severity by J Justin Milner & Melinda A Beck. (Future Medicine)
#Ellagitannins and #Ellagic acid Found in #Strawberries Inhibit the management of Hyperglycemia and Hypertension Linked to type 2 #Diabetes
Kyle J. Norton
Strawberry is a genius of Fragaria × ananassa belonging to the family Rosaceae.
The tasty fruits have been grown all over the world in a suitable climate for commercial profits and health benefits.
The major chemical compounds of strawberries include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.
Hypertension is a condition of abnormally high blood pressure.
High blood pressure can be acute or chronic. Acute high blood pressure most often occurs in people with sudden stress.
Sometimes it can be caused by intense physical exercise. As the heart must pump harder to provide the needs of nutrients and oxygen.
Most cases of chronic high blood pressure are associated with an unhealthy lifestyle and chronic diseases such as kidney disease, leading to the onset of strokes and cardiovascular disease.
Dr. Duangtep Y, the lead scientist in the team on heart disease and stroke at the District Health Office, Mae Fah Luang in the examine the risk of an unhealthy lifestyle and hypertension wrote, "Multiple logistic regression analysis shows the factors associated with hypertension among the hill tribe people studied were smoking, no or irregular exercise, being overweight, having obesity, and having a high-frequency intake of fatty foods".
These results strongly indicated that by following a healthy lifestyle, hypertension is preventable.
Unfortunately, according to the statistics, approximately 75 million American adults (32%) have high blood pressure. In other words, high blood pressure affects 1 in every 3 adults in the US.
In the differentiation of the association of high blood pressure contribution to cardiovascular disease and stroke, some scientists indicated these results overwhelmingly suggested hypertension has become a global burden and a growing public health problem worldwide.
On finding a natural ingredient or whole food for the prevention and treatment of hypertension, researchers at the Universidade de São Paulo assessed the fruit extracts of different strawberry cultivars for their potential to inhibit hypertension.
According to the DPPH radical scavenging assay, the fruit extracts inhibited alpha-amylase, alpha-glucosidase, and angiotensin I-converting enzyme (ACE) relevant for potentially managing hyperglycemia and hypertension.
The Strawberry's high alpha-glucosidase and angiotensin I-converting enzyme (ACE) inhibitory activity was attributed to the presence of ellagic acid, quercetin, and chlorogenic acid.
Water extracts of Jewel and Ovation cultivars strawberry had moderated ACE inhibition compared to low inhibition observed in other cultivars.
In vitro, strawberry fruit extracts inhibited the expression of angiotensin-1-converting enzyme (ACE) activity correlated to phenolic content and antioxidant activity.
These results suggested that strawberries could be considered a potential dietary source with anti-hyperglycemic and antihypertensive potential.
Dr. Cheplick S, the lead author said, "Strawberry cultivars with combined inhibitory potential against alpha-glucosidase and ACE and with moderate or low alpha-amylase inhibitory potential could be targeted for potential management of hyperglycemia-linked type 2 diabetes and related complication of hypertension".
Futhermore, by examing the potential health benefits of purified ellagitannins from strawberries in relation to the antiproliferative activity and in vitro inhibition of α-amylase, α-glucosidase, and angiotensin I-converting enzyme (ACE) relevant for the potential management of hyperglycemia and hypertension in patients with type 2 diabetes, researchers found that purified ellagitannins isolated from the strawberry has high α-amylase and ACE inhibitory activities.
However, these compounds had low α-glucosidase inhibitory activity.
In the final report of the experiment, Dr. Pinto Mda S, wrote, "The ellagitannins and ellagic acid have good potential for the management of hyperglycemia and hypertension linked to type 2 diabetes".
Taken together, adding a portion of strawberries into a daily diet may have a profound effect in reducing the risk and treatment of high blood pressure.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Dreferenced in medical research, such as the aily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Evaluation of antiproliferative, anti-type 2 diabetes, and antihypertension potentials of ellagitannins from strawberries (Fragaria × ananassa Duch.) using in vitro models, by Pinto Mda S, de Carvalho JE, Lajolo FM, Genovese MI, Shetty K(PubMed)
(2) Phenolic-linked variation in strawberry cultivars for the potential dietary management of hyperglycemia and related complications of hypertension. Cheplick S, Kwon YI, Bhowmik P, Shetty K.(PubMed)
(3) Functionality of bioactive compounds in Brazilian strawberry (Fragariax ananassa Duch.) cultivars: evaluation of hyperglycemia and hypertension potential using in vitro models. by da Silva Pinto M, Kwon YI, Apostolidis E, Lajolo FM, Genovese MI, Shetty K.
(PubMed)
(4) Association between an unhealthy lifestyle and other factors with hypertension among hill tribe populations of Mae Fah Luang District, Chiang Rai Province, Thailand by Duangtep Y1, Narksawat K, Chongsuwat R, Rojanavipart P. (PubMed)
Strawberry is a genius of Fragaria × ananassa belonging to the family Rosaceae.
The tasty fruits have been grown all over the world in a suitable climate for commercial profits and health benefits.
The major chemical compounds of strawberries include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.
Hypertension is a condition of abnormally high blood pressure.
High blood pressure can be acute or chronic. Acute high blood pressure most often occurs in people with sudden stress.
Sometimes it can be caused by intense physical exercise. As the heart must pump harder to provide the needs of nutrients and oxygen.
Most cases of chronic high blood pressure are associated with an unhealthy lifestyle and chronic diseases such as kidney disease, leading to the onset of strokes and cardiovascular disease.
Dr. Duangtep Y, the lead scientist in the team on heart disease and stroke at the District Health Office, Mae Fah Luang in the examine the risk of an unhealthy lifestyle and hypertension wrote, "Multiple logistic regression analysis shows the factors associated with hypertension among the hill tribe people studied were smoking, no or irregular exercise, being overweight, having obesity, and having a high-frequency intake of fatty foods".
These results strongly indicated that by following a healthy lifestyle, hypertension is preventable.
Unfortunately, according to the statistics, approximately 75 million American adults (32%) have high blood pressure. In other words, high blood pressure affects 1 in every 3 adults in the US.
In the differentiation of the association of high blood pressure contribution to cardiovascular disease and stroke, some scientists indicated these results overwhelmingly suggested hypertension has become a global burden and a growing public health problem worldwide.
On finding a natural ingredient or whole food for the prevention and treatment of hypertension, researchers at the Universidade de São Paulo assessed the fruit extracts of different strawberry cultivars for their potential to inhibit hypertension.
According to the DPPH radical scavenging assay, the fruit extracts inhibited alpha-amylase, alpha-glucosidase, and angiotensin I-converting enzyme (ACE) relevant for potentially managing hyperglycemia and hypertension.
The Strawberry's high alpha-glucosidase and angiotensin I-converting enzyme (ACE) inhibitory activity was attributed to the presence of ellagic acid, quercetin, and chlorogenic acid.
Water extracts of Jewel and Ovation cultivars strawberry had moderated ACE inhibition compared to low inhibition observed in other cultivars.
In vitro, strawberry fruit extracts inhibited the expression of angiotensin-1-converting enzyme (ACE) activity correlated to phenolic content and antioxidant activity.
These results suggested that strawberries could be considered a potential dietary source with anti-hyperglycemic and antihypertensive potential.
Dr. Cheplick S, the lead author said, "Strawberry cultivars with combined inhibitory potential against alpha-glucosidase and ACE and with moderate or low alpha-amylase inhibitory potential could be targeted for potential management of hyperglycemia-linked type 2 diabetes and related complication of hypertension".
Futhermore, by examing the potential health benefits of purified ellagitannins from strawberries in relation to the antiproliferative activity and in vitro inhibition of α-amylase, α-glucosidase, and angiotensin I-converting enzyme (ACE) relevant for the potential management of hyperglycemia and hypertension in patients with type 2 diabetes, researchers found that purified ellagitannins isolated from the strawberry has high α-amylase and ACE inhibitory activities.
However, these compounds had low α-glucosidase inhibitory activity.
In the final report of the experiment, Dr. Pinto Mda S, wrote, "The ellagitannins and ellagic acid have good potential for the management of hyperglycemia and hypertension linked to type 2 diabetes".
Taken together, adding a portion of strawberries into a daily diet may have a profound effect in reducing the risk and treatment of high blood pressure.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Dreferenced in medical research, such as the aily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Evaluation of antiproliferative, anti-type 2 diabetes, and antihypertension potentials of ellagitannins from strawberries (Fragaria × ananassa Duch.) using in vitro models, by Pinto Mda S, de Carvalho JE, Lajolo FM, Genovese MI, Shetty K(PubMed)
(2) Phenolic-linked variation in strawberry cultivars for the potential dietary management of hyperglycemia and related complications of hypertension. Cheplick S, Kwon YI, Bhowmik P, Shetty K.(PubMed)
(3) Functionality of bioactive compounds in Brazilian strawberry (Fragariax ananassa Duch.) cultivars: evaluation of hyperglycemia and hypertension potential using in vitro models. by da Silva Pinto M, Kwon YI, Apostolidis E, Lajolo FM, Genovese MI, Shetty K.
(PubMed)
(4) Association between an unhealthy lifestyle and other factors with hypertension among hill tribe populations of Mae Fah Luang District, Chiang Rai Province, Thailand by Duangtep Y1, Narksawat K, Chongsuwat R, Rojanavipart P. (PubMed)
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