Kyle J. Norton
Retinal degeneration is a condition of retinopathy associated with the gradual loss of neurons near the inner surface of the retina of the eyes.
Most cases of retinopathy are caused by abnormal blood flow.
The most common forms of retinal degeneration are macular degeneration which is a condition when the small central portion of the retina, (the macula) deteriorates and retinitis pigmentosa (RP) which is a rare genetic disorder involved a breakdown and loss of cells in the retina.
Retinal degeneration disease has been found to have a strong impact on daily life, ranging from performing basic functions to personal independence and mental health and vision loss.
According to the statistics, the overall prevalence of age-related macular degeneration (AMD) is in the range of 1.38%-1.55%) and retinitis pigmentosa is 1 in 3,500 to 1 in 4,000 individuals.
Age-related macular degeneration affects more than 1.75 million individuals in the United States, and the number is increasing rapidly due to the growth of an aging population. The number of persons having AMD will increase by 50% to 2.95 million in 2020.
Symptoms of retinal degeneration may include blurred central vision or a blind spot in the center of the visual field.
In severe cases, loss of vision may be possible, particularly in people over the age of 60.
Dr. Rita Ehrlich, the lead scientist said, "Age-related macular degeneration (AMD) is an ocular disease that causes damage to the retinal macula, mostly in the elderly. Normal aging processes can lead to structural and blood flow changes that can predispose patients to AMD".
Bilberry is a species of low-growing shrub in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as an herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
Researchers concerned about retinal degenerative diseases induced vision loss and retinal cell death examined the protective effects of the complex lutein formula (CLF) by combining several natural compounds: Calendula officinalis, Lycium barbarum, Vaccinium myrtillus, Cassia obtusifolia, and Rhodiola Rosea.
The formula showed significant protection of retinal functions in an animal model for light-induced retinal degeneration.
Before applying the formula, retinal function in animals exposed to light for 7 days decreased significantly.
However, CLF injection improved the superiority of the retinal function despite light exposure.
Furthermore, CLF restored a greater portion of the outer nuclear layer (ONL) (i.e. the nuclei of photoreceptors) in these animals compared to that of animals that had not received the formula after 7 days of light exposure.
The findings strongly suggested CLF including bilberry exerted retinal protection against the gradual loss of vision caused by degeneration.
Dr. the lead scientist after taking other factors into account wrote in the final report, "Our dietary CLF supplement attenuated retinal function loss resulting from long-term light exposure".
Long-term light exposure in animal models has been associated with retinal degeneration, as it damages the retina (phototoxicity) and decreases photoreceptors which have strong implications for age-related macular degeneration.
Taken altogether, bilberry used alone or combined with other herbal remedies may be considered functional remedies for the prevention of retinal degeneration, pending the validation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of a complex lutein formula in an animal model for light-induced retinal degeneration by Cheng YP1, Ke CY2, Kuo CC1, Lee YJ. (PubMed)
Wednesday, 21 June 2023
#Yoga Practice Remarkably Attenuates #Oxidativestress and Improved AQntioxidant Levels of the Body, Researchers Show.
Kyle J. Norton
Yoga practice may have a profound effect on improved immune function against foreign invasion, particularly in age-related immune suppression in elderly individuals
Immune function is a natural reaction of the immune system in protecting our body against foreign substances, cells, and tissues through the proper expression of the immune response.
Yoga, the ancient technique practice for harmonizing external and internal body well beings, through breath control, meditation, bodily movement, and gesture..... has been best known to people in the Western world and some parts of Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.
In the study to evaluate the effect of yoga on mucosal immune function and mental stress with saliva samples collected from 23 adult women (age: 60.4 ± 10.4 years) before and after 90 minutes of yoga stretching or rest researchers found that
1. Yoga group expressed a significantly higher immunoglobulin A (SIgA)(a subclass of Immunoglobulin A (IgA) plays an important role in the immune function of mucous membranes)
concentration and secretion rate after yoga than before and in compared to control
2. The levels of cortisol( higher levels of cortisol caused by stress have a negative effect on the immune system) concentration and secretion rate were lower and testosterone(which plays an important role in immune function in reducing the risk of autoimmune disease) secretion rate higher after yoga.
After further analysis and taking into account other co-founders, researchers said, " Yoga stretching can reduce stress and enhance mucosal immune function in elderly women."
Mucosal immune function is the first line of defense of the immune system against antigens and infection and in regulated immune overreaction from unharmful sources.
According to general belief, yoga twist, compress and standing posts exercise play an important role in ameliorated alterations in the number of immune cells and cytokine dysregulation through lowering stress hormones production.
Additionally, the exercises are also found to improve energy and energy balancing in the body which are necessary for the immune system to function properly.
In the concerns of yoga expression in enhanced immune system through a number of mechanisms, researchers at Daejeon University conducted a study in healthy adults, to highlight the beneficial effects of yoga practice on bio-parameters related to immune expression and found that
More importantly, in the review on the effects of yoga poses on psychological conditions including anxiety and depression, pain syndromes, cardiovascular, autoimmune, and immune conditions, and on pregnancy.
Dr. Field T, at the University of Miami School of Medicine, opinionated that yoga intervention induced less production of cortisol, the hormone that has a negative effect on the immune system due to stress may indeed have a profound effect in enhanced immune cellular function, particularly in psychological conditions in regulating the autoimmune and immune conditions.
Taking it all together, There is no doubt that yoga practice may have a therapeutic effect in improved immune function against foreign substances, cells, and tissues through a number of mechanisms involving different pathways.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Yoga stretching for improving salivary immune function and mental stress in middle-aged and older adults by Eda N1, Ito H2, Shimizu K3, Suzuki S4, Lee E4, Akama T1.(PubMed)
(2) Regular Yoga Practice Improves Antioxidant Status, Immune Function, and Stress Hormone Releases in Young Healthy People: A Randomized, Double-Blind, Controlled Pilot Study by Lim SA1, Cheong KJ1.(PubMed)
(3) Yoga clinical research review by Field T1.(PubMed)
Yoga practice may have a profound effect on improved immune function against foreign invasion, particularly in age-related immune suppression in elderly individuals
Immune function is a natural reaction of the immune system in protecting our body against foreign substances, cells, and tissues through the proper expression of the immune response.
Yoga, the ancient technique practice for harmonizing external and internal body well beings, through breath control, meditation, bodily movement, and gesture..... has been best known to people in the Western world and some parts of Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.
In the study to evaluate the effect of yoga on mucosal immune function and mental stress with saliva samples collected from 23 adult women (age: 60.4 ± 10.4 years) before and after 90 minutes of yoga stretching or rest researchers found that
1. Yoga group expressed a significantly higher immunoglobulin A (SIgA)(a subclass of Immunoglobulin A (IgA) plays an important role in the immune function of mucous membranes)
concentration and secretion rate after yoga than before and in compared to control
2. The levels of cortisol( higher levels of cortisol caused by stress have a negative effect on the immune system) concentration and secretion rate were lower and testosterone(which plays an important role in immune function in reducing the risk of autoimmune disease) secretion rate higher after yoga.
After further analysis and taking into account other co-founders, researchers said, " Yoga stretching can reduce stress and enhance mucosal immune function in elderly women."
Mucosal immune function is the first line of defense of the immune system against antigens and infection and in regulated immune overreaction from unharmful sources.
According to general belief, yoga twist, compress and standing posts exercise play an important role in ameliorated alterations in the number of immune cells and cytokine dysregulation through lowering stress hormones production.
Additionally, the exercises are also found to improve energy and energy balancing in the body which are necessary for the immune system to function properly.
In the concerns of yoga expression in enhanced immune system through a number of mechanisms, researchers at Daejeon University conducted a study in healthy adults, to highlight the beneficial effects of yoga practice on bio-parameters related to immune expression and found that
1. The yoga group expressed significantly reduced levels of relative oxygen species(ROS), including include peroxides, superoxide, hydroxyl radical, and singlet oxygen through regulating cellular metabolism in the production of ROS which have been found to have a direct influence on T cells activation, apoptosis, and immune hyporesponsiveness.
2. Yoga group demonstrated an improvement of immunity in increased levels of antioxidant in compared to control, through the effects of free radical scavengers in reduced cellular damage caused by overexpression of ROS in inducing inflammation.
3. Yoga practice also significantly increased immune-related cytokines, such as interleukin-12, and interferon-γ,....which play an important role in reduced risk of inflammatory and autoimmune diseases, including diabetes, atherosclerosis, rheumatic arthritis, and cancer.
4. The levels of plasma levels of adrenalin were reduced and serotonin was increased in the yoga group compared with the control group.
Elevation of plasma levels of adrenalin caused by stress may suppress the immune system and increased levels of serotonin showed an opposite effect in increased killing ability of natural killer (NK) cells.
After taking into account of other co-founders, Dr. Lim SA, the led researcher said, "Regular yoga practice remarkably attenuated oxidative stress (caused by an imbalance of between the production of free radicals and antioxidants) and improved antioxidant levels of the body. Moreover, yoga beneficially affected stress hormone releases as well as partially improved immune function".
2. Yoga group demonstrated an improvement of immunity in increased levels of antioxidant in compared to control, through the effects of free radical scavengers in reduced cellular damage caused by overexpression of ROS in inducing inflammation.
3. Yoga practice also significantly increased immune-related cytokines, such as interleukin-12, and interferon-γ,....which play an important role in reduced risk of inflammatory and autoimmune diseases, including diabetes, atherosclerosis, rheumatic arthritis, and cancer.
4. The levels of plasma levels of adrenalin were reduced and serotonin was increased in the yoga group compared with the control group.
Elevation of plasma levels of adrenalin caused by stress may suppress the immune system and increased levels of serotonin showed an opposite effect in increased killing ability of natural killer (NK) cells.
After taking into account of other co-founders, Dr. Lim SA, the led researcher said, "Regular yoga practice remarkably attenuated oxidative stress (caused by an imbalance of between the production of free radicals and antioxidants) and improved antioxidant levels of the body. Moreover, yoga beneficially affected stress hormone releases as well as partially improved immune function".
More importantly, in the review on the effects of yoga poses on psychological conditions including anxiety and depression, pain syndromes, cardiovascular, autoimmune, and immune conditions, and on pregnancy.
Dr. Field T, at the University of Miami School of Medicine, opinionated that yoga intervention induced less production of cortisol, the hormone that has a negative effect on the immune system due to stress may indeed have a profound effect in enhanced immune cellular function, particularly in psychological conditions in regulating the autoimmune and immune conditions.
Taking it all together, There is no doubt that yoga practice may have a therapeutic effect in improved immune function against foreign substances, cells, and tissues through a number of mechanisms involving different pathways.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Yoga stretching for improving salivary immune function and mental stress in middle-aged and older adults by Eda N1, Ito H2, Shimizu K3, Suzuki S4, Lee E4, Akama T1.(PubMed)
(2) Regular Yoga Practice Improves Antioxidant Status, Immune Function, and Stress Hormone Releases in Young Healthy People: A Randomized, Double-Blind, Controlled Pilot Study by Lim SA1, Cheong KJ1.(PubMed)
(3) Yoga clinical research review by Field T1.(PubMed)
#Phytochemical 3,3'-#Diindolylmethane Inhibits the microRNAs (miRNAs) Expression Against #ColonCancer (CAC) Pathogenesis, Scientists Say
By Kyle J. Norton
3,3'-Diindolylmethane or DIM may have a p[otential effect on the treatment of cancer with no side effects, according to studies.
Cancer is a group of diseases characterized by the cell growth uncontrollably in the tissue of certain organs, due to the alternation of cell DNA.
Epidemiologically, researchers do not the exact causes of cancer. They cannot explain why people with the same health conditions in the same family, are prone to the disease while others do not.
Most cases of cancer start in the cells on the surface of the inner lining tissue of an organ and at the advanced stage, cancer cells can travel a distance away from the original site to infect other tissues and organs through the circulation of blood and fluids, leading to secondary metastasis.
Cancer diagnosed at the early stage can have a survival rate up to 100%, depending on the type of cancer.
All cancers shared the general symptoms of unintended weight loss, loss of appetite, fatigue, tiredness, and gastrointestinal discomfort.
Furthermore, most cancers at the early stage do not induce any symptoms, however, at the later stage, the overgrowth tumor may press on the nearby blood vessels and nerve cells, leading to severe bleeding and pain.
Although there are several risk factors associated with the onset of cancer, some researchers suggested the increase in aging that leads to a number of abnormal alternations may be one of the major causes.
Dr. Jan R. Aunan, the lead scientist wrote in the study of the biological role of age and cancer, "Aging is the inevitable time-dependent decline in physiological organ function and is a major risk factor for cancer development".
And, "Mechanisms of aging are also found to occur in carcinogenesis, albeit with shared or divergent end-results. It is now clear that aging and cancer development either share or diverge in several disease mechanisms. Such mechanisms include the role of genomic instability, telomere attrition, epigenetic changes, loss of proteostasis, decreased nutrient sensing and altered metabolism, but also cellular senescence and stem cell function".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Scientists concerned with the side effect of chemotherapy for the treatment of cancer examined the effects of I3C and its dimeric product, 3, 3'-diindolylmethane (DIM) anti-proliferative and anti-cancer activities against human cancer cells.
Application of I3C and its dimeric product, 3, 3'-diindolylmethane (DIM) exerted a strong activity in the inhibition of altered expression and exhibition of the functions of proteins associated with cell cycle arrest.
I3C and its dimeric product, 3, 3'-diindolylmethane (DIM) deactivated the signal transduction pathways in the stimulation of cancer cell growth.
Furthermore, the phytochemicals suppressed the genes associated with cancer cell survival and proliferation and the protein involved in the generation of new blood vessels for the tumor.
Moreover, the tested bioactive compound also activated the protein associated with the pro-apoptosis against the gene involved in anti-apoptosis of the cancer cells.
Additionally, I3C and its dimeric product, 3, 3'-diindolylmethane (DIM) also overexpressed the gene involved in cell cycle arrest against the progression of cancer.
Dr.Noroozi MK and colleagues wrote at the end of the experiment, "I3C and its dimeric product, 3, 3'-diindolylmethane (DIM), have been widely investigated for their importance against a number of human cancers both in vitro and in vivo".
In the microRNA-21 analysis, researchers found that DIM inhibits the microRNAs (miRNAs) expression against colon cancer (CAC) pathogenesis.
Where MicroRNAs (miRNAs) are a class of small noncoding RNAs of ∼22nt in length involved in the regulation of gene expression including inflammation and angiogenesis.
In mesothelioma, injection of DIM exerted anti-mesothelioma potentials, by lowering the expression of microRNA regulatory activities by suppressing macrophage infiltration and pro-inflammatory cytokines.
In other words, DIM modulated the immune response against the onset and progression of mesothelioma in stimulating the production of oxidative stress due to the overexpression of inflammatory cytokines in the initiation of the disease.
Taken altogether, DIM may be considered a supplement for the prevention and combined with primary medicine for the treatment of cancer, pending the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Molecular targets, anti-cancer properties and potency of synthetic indole-3-carbinol derivatives by Noroozi MK1, Mahmoodi M1, Jafarzadeh A1, Darekordi A2, Hajizadeh MR1, Hassanshahi G. (PubMed)
(2) Enhancing miR-132 expression by aryl hydrocarbon receptor attenuates tumorigenesis associated with chronic colitis by Alzahrani AM1, Hanieh H2, Ibrahim HM2, Mohafez O3, Shehata T4, Bani Ismail M2, Alfwuaires M. (PubMed)
(3) The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks by Jan R. Aunan,1,2,* William C Cho,3 and Kjetil Søreide. (PubMed)
3,3'-Diindolylmethane or DIM may have a p[otential effect on the treatment of cancer with no side effects, according to studies.
Cancer is a group of diseases characterized by the cell growth uncontrollably in the tissue of certain organs, due to the alternation of cell DNA.
Epidemiologically, researchers do not the exact causes of cancer. They cannot explain why people with the same health conditions in the same family, are prone to the disease while others do not.
Most cases of cancer start in the cells on the surface of the inner lining tissue of an organ and at the advanced stage, cancer cells can travel a distance away from the original site to infect other tissues and organs through the circulation of blood and fluids, leading to secondary metastasis.
Cancer diagnosed at the early stage can have a survival rate up to 100%, depending on the type of cancer.
All cancers shared the general symptoms of unintended weight loss, loss of appetite, fatigue, tiredness, and gastrointestinal discomfort.
Furthermore, most cancers at the early stage do not induce any symptoms, however, at the later stage, the overgrowth tumor may press on the nearby blood vessels and nerve cells, leading to severe bleeding and pain.
Although there are several risk factors associated with the onset of cancer, some researchers suggested the increase in aging that leads to a number of abnormal alternations may be one of the major causes.
Dr. Jan R. Aunan, the lead scientist wrote in the study of the biological role of age and cancer, "Aging is the inevitable time-dependent decline in physiological organ function and is a major risk factor for cancer development".
And, "Mechanisms of aging are also found to occur in carcinogenesis, albeit with shared or divergent end-results. It is now clear that aging and cancer development either share or diverge in several disease mechanisms. Such mechanisms include the role of genomic instability, telomere attrition, epigenetic changes, loss of proteostasis, decreased nutrient sensing and altered metabolism, but also cellular senescence and stem cell function".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Scientists concerned with the side effect of chemotherapy for the treatment of cancer examined the effects of I3C and its dimeric product, 3, 3'-diindolylmethane (DIM) anti-proliferative and anti-cancer activities against human cancer cells.
Application of I3C and its dimeric product, 3, 3'-diindolylmethane (DIM) exerted a strong activity in the inhibition of altered expression and exhibition of the functions of proteins associated with cell cycle arrest.
I3C and its dimeric product, 3, 3'-diindolylmethane (DIM) deactivated the signal transduction pathways in the stimulation of cancer cell growth.
Furthermore, the phytochemicals suppressed the genes associated with cancer cell survival and proliferation and the protein involved in the generation of new blood vessels for the tumor.
Moreover, the tested bioactive compound also activated the protein associated with the pro-apoptosis against the gene involved in anti-apoptosis of the cancer cells.
Additionally, I3C and its dimeric product, 3, 3'-diindolylmethane (DIM) also overexpressed the gene involved in cell cycle arrest against the progression of cancer.
Dr.Noroozi MK and colleagues wrote at the end of the experiment, "I3C and its dimeric product, 3, 3'-diindolylmethane (DIM), have been widely investigated for their importance against a number of human cancers both in vitro and in vivo".
In the microRNA-21 analysis, researchers found that DIM inhibits the microRNAs (miRNAs) expression against colon cancer (CAC) pathogenesis.
Where MicroRNAs (miRNAs) are a class of small noncoding RNAs of ∼22nt in length involved in the regulation of gene expression including inflammation and angiogenesis.
In mesothelioma, injection of DIM exerted anti-mesothelioma potentials, by lowering the expression of microRNA regulatory activities by suppressing macrophage infiltration and pro-inflammatory cytokines.
In other words, DIM modulated the immune response against the onset and progression of mesothelioma in stimulating the production of oxidative stress due to the overexpression of inflammatory cytokines in the initiation of the disease.
Taken altogether, DIM may be considered a supplement for the prevention and combined with primary medicine for the treatment of cancer, pending the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Molecular targets, anti-cancer properties and potency of synthetic indole-3-carbinol derivatives by Noroozi MK1, Mahmoodi M1, Jafarzadeh A1, Darekordi A2, Hajizadeh MR1, Hassanshahi G. (PubMed)
(2) Enhancing miR-132 expression by aryl hydrocarbon receptor attenuates tumorigenesis associated with chronic colitis by Alzahrani AM1, Hanieh H2, Ibrahim HM2, Mohafez O3, Shehata T4, Bani Ismail M2, Alfwuaires M. (PubMed)
(3) The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks by Jan R. Aunan,1,2,* William C Cho,3 and Kjetil Søreide. (PubMed)
#Gingeextract Exerts Protective Effects Against Ferrous Sulfate-Induced Liver and Kidney Toxicity, Researchers Reveal
Kyle J. Norton
The kidneys play a critical role in filtering wastes from the breakdown of active muscle and the food you eat and removing extra water from the blood through urinary secretion.
Kidney dysfunction can reduce the body's ability to clean your blood, and filter extra water out of your blood, leading to fluid retention and high blood pressure in the early stage.
Chronic kidney disease is a gradual loss of kidney function over time. Chronic kidney failure is the end stage of chronic kidney disease which has been found in a high number in patients with diabetes, high blood pressure, and other disorders.
Unlike many diseases, kidney disease often has no symptoms until it is in a very advanced stage.
Acute kidney dysfunction or acute kidney failure is a result of insufficient blood flow to the kidneys such as renal hypertension. These types of kidney dysfunction can be cured if the causes are found.
Most cases of acute kidney dysfunction may be associated with toxins accumulated in the kidney organs, leading to nephrotoxicity.
Nephrotoxicity is a condition of kidney function caused by exposure to toxic chemicals or an overdose of certain medications.
Some researchers suggested that mercury toxicity may be one of the major causes of kidney toxicity in the world as its concentration is rising continuously due to increased industrial, medicinal, and domestic uses.
The World Health Organization wrote, "Exposure to mercury – even small amounts – may cause serious health problems, and is a threat to the child's development in utero and early in life.".
And, " Mercury may have toxic effects on the nervous, digestive and immune systems, and on lungs, kidneys, skin, and eyes.".
The results strongly suggested that mercury toxicity alters biochemical parameters associated with the risk of kidney dysfunction.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the promotion of kidney function investigated the ginger effect on kidneys against mercury toxicity.
Male Sprague-Dawley rats (150±10g, n=6 per group) selected for the study were administered HgCl2 (12μmol/kg, ip; once only) then by the treatment of Zingiber officinale Rosc. extract (ZO: 125mg/kg, po) and 6-gingerol (GG: 50mg/kg, PO) for three days after 24h of HgCl2 administration.
Acute HgCl2 administration showed a significant alternation of various biochemical parameters associated with kidney damage including transaminases, alkaline phosphatase, found in patients with renal failure, and Lactate dehydrogenase, a biomarker for early renal damage.
Furthermore, HgCl2 also altered the levels of bilirubin, a predictor of the development of chronic kidney disease, and gamma-glutamyltransferase (GGT), elevated levels of GGT were found to induce chronic kidney diseases.
The alternation of creatinine, uric acid, and blood urea nitrogen contents used for a monitoring of renal function was also altered by the injection of HgCl2.
These results suggested serious kidney damage was induced by the toxicity of HgCl2.
Additionally, the injection of HgCl2 also decreased the levels of antioxidants produced by the host and elevated the production of free radicals.
Treatment by Zingiber officinale extract and 6-gingerol reversed all the parameters changed against acute mercuric chloride intoxication by preventing oxidative degradation of biological membranes from metal-mediated free radical attacks through their antioxidant activity.
In order to reveal additional information about ginger anti toxicity properties, researchers examined the protective role of the hydroalcoholic extract of ginger (Zingiber officinale) against ferrous sulfate-induced hepatic and renal functional disorders and histological damages in rats.
Rats selected for the study were divided into four groups (n=7): Sham, Sham + G.E (ginger extract, 400 mg/kg/day for 14 days), FS (ferrous sulfate, 30 mg/kg/day for 14 days), FS+G.E (ferrous sulfate, 30 mg/kg/day for 14 days; ginger extract, 400 mg/kg/day for 11 days from the fourth day of ferrous sulfate injection).
Compared with Sham and Sham + G.E groups, administration of ferrous sulfate resulted in kidney dysfunction observed by the alternation of a number of parameters, including lower creatinine clearance and higher fractional excretion of sodium.
Moreover, ginger extract restored the levels of serum total protein, albumin, glucose, triglycerides, and cholesterol and decreased bilirubin concentration in the blood similar to those of HgCl2 rats.
Dr. Gholampour F, the lead scientist after taking into account co and confounders wrote, "ginger extract appears to exert protective effects against ferrous sulfate-induced hepatic and renal toxicity by reducing lipid peroxidation and chelating iron".
Taken altogether, ginger may be considered a functional remedy for the prevention and treatment of kidney dysfunction associated with heavy metal toxicity, pending the confirmation of a large sample size and multicenter study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Zingiber officinale and 6-gingerol alleviate liver and kidney dysfunctions and oxidative stress induced by mercuric chloride in male rats: A protective approach by Joshi D1, Srivastav SK2, Belemkar S3, Dixit VA3. (PubMed)
(2) The protective effect of hydroalcoholic extract of Ginger (Zingiber officinaleRosc.) against iron-induced functional and histological damages in rat liver and kidney by Gholampour F1, Behzadi Ghiasabadi F1, Owji SM2, Vatanparast J1. (PubMed)
(3) Mercury and health by WHO
The kidneys play a critical role in filtering wastes from the breakdown of active muscle and the food you eat and removing extra water from the blood through urinary secretion.
Kidney dysfunction can reduce the body's ability to clean your blood, and filter extra water out of your blood, leading to fluid retention and high blood pressure in the early stage.
Chronic kidney disease is a gradual loss of kidney function over time. Chronic kidney failure is the end stage of chronic kidney disease which has been found in a high number in patients with diabetes, high blood pressure, and other disorders.
Unlike many diseases, kidney disease often has no symptoms until it is in a very advanced stage.
Acute kidney dysfunction or acute kidney failure is a result of insufficient blood flow to the kidneys such as renal hypertension. These types of kidney dysfunction can be cured if the causes are found.
Most cases of acute kidney dysfunction may be associated with toxins accumulated in the kidney organs, leading to nephrotoxicity.
Nephrotoxicity is a condition of kidney function caused by exposure to toxic chemicals or an overdose of certain medications.
Some researchers suggested that mercury toxicity may be one of the major causes of kidney toxicity in the world as its concentration is rising continuously due to increased industrial, medicinal, and domestic uses.
The World Health Organization wrote, "Exposure to mercury – even small amounts – may cause serious health problems, and is a threat to the child's development in utero and early in life.".
And, " Mercury may have toxic effects on the nervous, digestive and immune systems, and on lungs, kidneys, skin, and eyes.".
The results strongly suggested that mercury toxicity alters biochemical parameters associated with the risk of kidney dysfunction.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the promotion of kidney function investigated the ginger effect on kidneys against mercury toxicity.
Male Sprague-Dawley rats (150±10g, n=6 per group) selected for the study were administered HgCl2 (12μmol/kg, ip; once only) then by the treatment of Zingiber officinale Rosc. extract (ZO: 125mg/kg, po) and 6-gingerol (GG: 50mg/kg, PO) for three days after 24h of HgCl2 administration.
Acute HgCl2 administration showed a significant alternation of various biochemical parameters associated with kidney damage including transaminases, alkaline phosphatase, found in patients with renal failure, and Lactate dehydrogenase, a biomarker for early renal damage.
Furthermore, HgCl2 also altered the levels of bilirubin, a predictor of the development of chronic kidney disease, and gamma-glutamyltransferase (GGT), elevated levels of GGT were found to induce chronic kidney diseases.
The alternation of creatinine, uric acid, and blood urea nitrogen contents used for a monitoring of renal function was also altered by the injection of HgCl2.
These results suggested serious kidney damage was induced by the toxicity of HgCl2.
Additionally, the injection of HgCl2 also decreased the levels of antioxidants produced by the host and elevated the production of free radicals.
Treatment by Zingiber officinale extract and 6-gingerol reversed all the parameters changed against acute mercuric chloride intoxication by preventing oxidative degradation of biological membranes from metal-mediated free radical attacks through their antioxidant activity.
In order to reveal additional information about ginger anti toxicity properties, researchers examined the protective role of the hydroalcoholic extract of ginger (Zingiber officinale) against ferrous sulfate-induced hepatic and renal functional disorders and histological damages in rats.
Rats selected for the study were divided into four groups (n=7): Sham, Sham + G.E (ginger extract, 400 mg/kg/day for 14 days), FS (ferrous sulfate, 30 mg/kg/day for 14 days), FS+G.E (ferrous sulfate, 30 mg/kg/day for 14 days; ginger extract, 400 mg/kg/day for 11 days from the fourth day of ferrous sulfate injection).
Compared with Sham and Sham + G.E groups, administration of ferrous sulfate resulted in kidney dysfunction observed by the alternation of a number of parameters, including lower creatinine clearance and higher fractional excretion of sodium.
Moreover, ginger extract restored the levels of serum total protein, albumin, glucose, triglycerides, and cholesterol and decreased bilirubin concentration in the blood similar to those of HgCl2 rats.
Dr. Gholampour F, the lead scientist after taking into account co and confounders wrote, "ginger extract appears to exert protective effects against ferrous sulfate-induced hepatic and renal toxicity by reducing lipid peroxidation and chelating iron".
Taken altogether, ginger may be considered a functional remedy for the prevention and treatment of kidney dysfunction associated with heavy metal toxicity, pending the confirmation of a large sample size and multicenter study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Zingiber officinale and 6-gingerol alleviate liver and kidney dysfunctions and oxidative stress induced by mercuric chloride in male rats: A protective approach by Joshi D1, Srivastav SK2, Belemkar S3, Dixit VA3. (PubMed)
(2) The protective effect of hydroalcoholic extract of Ginger (Zingiber officinaleRosc.) against iron-induced functional and histological damages in rat liver and kidney by Gholampour F1, Behzadi Ghiasabadi F1, Owji SM2, Vatanparast J1. (PubMed)
(3) Mercury and health by WHO
#Turmeric Extract Exerts Multiple Therapeutic Activities Against #Hepatotoxicity, According to Studies
Kyle J. Norton
Liver toxicity or hepatotoxicity is a condition that the liver is damaged by chemical substances, including drug-induced liver injury is a cause of acute and chronic liver disease.
The liver is the largest internal organ not only processes the function of filtering the blood coming from the intestine before passing them to other parts of the body but also secretes bile that aids the function of the digestive system in digesting food, building strong cell membranes, production of vitamin D and steroid hormones.
Symptoms of liver toxicity may include stomach pain, upset stomach, persistent tiredness, and dark-colored urine but light-colored bowel movements, particularly in the expression of jaundice found in the skin and eyes.
Other researchers suggested that psychological symptoms such as stress, anxiety, and depression are also found in patients with liver toxicity.
The most common causes of liver toxicity are associated with drugs.
According to a critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury and 48 drugs had more than 50 case reports.
Believe it or not, amoxicillin-clavulanate has been found to induce liver toxicity in approximately one out of 2300 users.
However, according to a study published by the Journal of Phytopharmacology, live toxicity can also be caused by interruption of the liver function in metabolizing substances.
Dr. Meagan Thompson, the lead scientist wrote, " The human liver metabolizes substances via oxidation, reduction, hydration, hydrolysis, condensation, conjugation, or isomerization. Interruption of these processes can lead to hepatotoxicity, causing liver cancer, cirrhosis, and Hepatitis C, respectively".
And "Such diseases are responsible for higher mortality rates worldwide. The present review focuses on highlighting various plants that are hepatoprotective, and hepatotoxic, and the challenges faced by phytopharmaceuticals".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of liver toxicity scientists evaluated the therapeutic potential of Curcuma longa (200mgkg-1, po) and curcumin (80mgkg-1, po) for their hepatoprotective efficacy against mercuric chloride (HgCl2: 12μmolkg-1, ip; once only) hepatotoxicity.
According to the results from the testes assays, therapy of Curcuma longa or curcumin restored the HgCl2 administration that alters various biochemical parameters, including transaminases, alkaline phosphatase, lactate dehydrogenase, bilirubin, gamma-glutamyl transferase, triglycerides, and cholesterol contents.
Furthermore, therapy of Curcuma longa extract or curcumin also inhibited a concomitant decline in the serum of protein and albumin concentration an indication of liver injury.
The findings suggested that Curcuma longa extract or curcumin processed the ability to alleviate the hepatotoxic effects caused by HgCl2 in rats.
In order to reveal more information about turmeric detoxed activity, researchers examined the protective effect of turmeric extract against doxorubicin (DOX)-induced liver toxicity in rats.
According to the tested assays, turmeric extract exerted multiple therapeutic activities that ameliorative effect against DOX-induced increased serum levels of alanine aminotransferase, aspartate aminotransferase, nitric oxide, albumin in liver tissue
According to the Biochemical and histopathological findings, turmeric extract has multiple therapeutic activities by ameliorating the effect of DOX-induced hepatotoxicity.
Dr. Mohamad RH, the lead scientist said, "The present findings conclude that the turmeric extract has multiple therapeutic activities that block the hepatic....toxicities".
Taken altogether, turmeric processed with a high amount of bioactive compound curcumin may be considered a supplement for the prevention of liver toxicity, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric as a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcuma longa Linn. extract and curcumin protect CYP 2E1 enzymatic activity against mercuric chloride-induced hepatotoxicity and oxidative stress: A protective approach by Joshi D1, Mittal DK2, Shukla S2, Srivastav SK3, Dixit VA. (PubMed)
(2)The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats by Mohamad RH1, El-Bastawesy AM, Zekry ZK, Al-Mehdar HA, Al-Said MG, Aly SS, Sharawy SM, El-Merzabani MM. (PubMed)
(3) Hepatotoxicity by Drugs: The Most Common Implicated Agents by Einar S. Björnsson. (PMC)
(4) Hepatotoxicity: Treatment, causes, and applications of medicinal plants as therapeutic agents by Meagan Thompson, Yogini Jaiswal, Ilya Wang, Leonard Williams( the Journal of Phytopharmacology)
Liver toxicity or hepatotoxicity is a condition that the liver is damaged by chemical substances, including drug-induced liver injury is a cause of acute and chronic liver disease.
The liver is the largest internal organ not only processes the function of filtering the blood coming from the intestine before passing them to other parts of the body but also secretes bile that aids the function of the digestive system in digesting food, building strong cell membranes, production of vitamin D and steroid hormones.
Symptoms of liver toxicity may include stomach pain, upset stomach, persistent tiredness, and dark-colored urine but light-colored bowel movements, particularly in the expression of jaundice found in the skin and eyes.
Other researchers suggested that psychological symptoms such as stress, anxiety, and depression are also found in patients with liver toxicity.
The most common causes of liver toxicity are associated with drugs.
According to a critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury and 48 drugs had more than 50 case reports.
Believe it or not, amoxicillin-clavulanate has been found to induce liver toxicity in approximately one out of 2300 users.
However, according to a study published by the Journal of Phytopharmacology, live toxicity can also be caused by interruption of the liver function in metabolizing substances.
Dr. Meagan Thompson, the lead scientist wrote, " The human liver metabolizes substances via oxidation, reduction, hydration, hydrolysis, condensation, conjugation, or isomerization. Interruption of these processes can lead to hepatotoxicity, causing liver cancer, cirrhosis, and Hepatitis C, respectively".
And "Such diseases are responsible for higher mortality rates worldwide. The present review focuses on highlighting various plants that are hepatoprotective, and hepatotoxic, and the challenges faced by phytopharmaceuticals".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of liver toxicity scientists evaluated the therapeutic potential of Curcuma longa (200mgkg-1, po) and curcumin (80mgkg-1, po) for their hepatoprotective efficacy against mercuric chloride (HgCl2: 12μmolkg-1, ip; once only) hepatotoxicity.
According to the results from the testes assays, therapy of Curcuma longa or curcumin restored the HgCl2 administration that alters various biochemical parameters, including transaminases, alkaline phosphatase, lactate dehydrogenase, bilirubin, gamma-glutamyl transferase, triglycerides, and cholesterol contents.
Furthermore, therapy of Curcuma longa extract or curcumin also inhibited a concomitant decline in the serum of protein and albumin concentration an indication of liver injury.
The findings suggested that Curcuma longa extract or curcumin processed the ability to alleviate the hepatotoxic effects caused by HgCl2 in rats.
In order to reveal more information about turmeric detoxed activity, researchers examined the protective effect of turmeric extract against doxorubicin (DOX)-induced liver toxicity in rats.
According to the tested assays, turmeric extract exerted multiple therapeutic activities that ameliorative effect against DOX-induced increased serum levels of alanine aminotransferase, aspartate aminotransferase, nitric oxide, albumin in liver tissue
According to the Biochemical and histopathological findings, turmeric extract has multiple therapeutic activities by ameliorating the effect of DOX-induced hepatotoxicity.
Dr. Mohamad RH, the lead scientist said, "The present findings conclude that the turmeric extract has multiple therapeutic activities that block the hepatic....toxicities".
Taken altogether, turmeric processed with a high amount of bioactive compound curcumin may be considered a supplement for the prevention of liver toxicity, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric as a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcuma longa Linn. extract and curcumin protect CYP 2E1 enzymatic activity against mercuric chloride-induced hepatotoxicity and oxidative stress: A protective approach by Joshi D1, Mittal DK2, Shukla S2, Srivastav SK3, Dixit VA. (PubMed)
(2)The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats by Mohamad RH1, El-Bastawesy AM, Zekry ZK, Al-Mehdar HA, Al-Said MG, Aly SS, Sharawy SM, El-Merzabani MM. (PubMed)
(3) Hepatotoxicity by Drugs: The Most Common Implicated Agents by Einar S. Björnsson. (PMC)
(4) Hepatotoxicity: Treatment, causes, and applications of medicinal plants as therapeutic agents by Meagan Thompson, Yogini Jaiswal, Ilya Wang, Leonard Williams( the Journal of Phytopharmacology)
#ArtichokeLeaves (Blades, Petioles, and Midribs) Exert the Different Antioxidant Properties., Researchers Reveal
Kyle J. Norton
Scientists may have found a herbal remedy that processed significant antioxidant activity against the onset and progression of oxidative stress-related diseases, according to studies.
Oxidative stress-related conditions are the class of diseases associated with cellular damage, including the alternation of cell DNA, and damage of lipids and proteins.
The list of chronic diseases caused by cell oxidation is very long, including atherosclerosis, cancer, diabetes, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.
The most common causes of oxidative stress are overexpression of free radicals in the induction of a chain reaction.
Due to the unstable nature of free radicals with unpaired electrons in the outer ring, free radicals are ready to donate or intercept the electrons from other atoms, leading to a chain reaction that can not be stopped until the outring electron are either paired or inhibited by antioxidants.
In contrast to the general belief, the damage caused by free radicals is overly exaggerated, under normal conditions, free radicals produced by internal or external sources are needed by our body for cellular responses and immune function.
However, overexpression of free radicals also known as oxidative stress can be a danger to our health.
Oxidative stress can be acute or chronic. Acute oxidative stress is caused by a sudden burst of free radicals due to stress or external sources, in most cases can be inhibited by increasing antioxidant enzymes in the lung.
Chronic oxidative stress is caused by the unbalanced ratio of free radicals and antioxidant enzymes produced by our bodies. The condition is either caused by overexpression of free radicals or depletion of antioxidants enzymes or both.
There are many risk factors that cause oxidative stress. However, in the concerns of the prevalence of chronic diseases associated with the Western diet, some researchers suggested that the link of oxidative diseases in the Western world may result from the promotion of the Western diet over the past few decades.
Dr. Ildiko Erdelyi, the lead scientist said, "A Western-style diet (WD), defined by high-fat, low-calcium, and vitamin D content, is associated with increased risk of human colorectal cancer. Understanding molecular mechanisms altered by the WD is crucial to develop preventive and therapeutic strategies".
And, "consumption of a WD interferes with networks of related biological response pathways involving colonic lipid metabolism, oxidative stress, and the immune response".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Scientists on finding a natural ingredient for the treatment of oxidative stress-related diseases examined the antioxidant activity of artichokes in the rat model.
Artichoke extracts showed good efficiency in the inhibition in vitro of LDL oxidation. Injection of artichoke extracts also increased the levels of antioxidant glutathione peroxidase against oxidative damage in the tested subjects compared to the control group.
Injection of artichoke extracts also inhibited the expression of a protein oxidation biomarker (2-Aminoadipic semialdehyde) compared to the control group.
In order to reveal more information on artichoke antioxidant activity, researchers examined the phenolic compound content and composition and the antioxidant activity of leaf parts [blades (SLB), petioles, and midribs (SPM)] from various Greek artichoke genotypes.
Most of the genotypes' leaf blades had a high flavonoid content (mainly luteolin glycoside derivatives), which ranged between 49 and 78% of total phenolic compounds (TPC).
Petioles and midribs phenolic acids (mainly hydroxycinnamic acid derivatives) were the main phenolic compounds, ranging between 64 and 76% of TPC,
The antioxidant activity of blades was significantly higher than that of petiole and midribs for all the genotypes according to the tested assays.
The results of antioxidant differentiation suggested that artichoke leaves (blades, petioles, and midribs) show different bioactive compound profiles in stimulating the different antioxidant properties.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of oxidative stress-related diseases through its antioxidant activity, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) In vitro antioxidant activities of edible artichoke (Cynara scolymus L.) and effect on biomarkers of antioxidants in rats by Jiménez-Escrig A1, Dragsted LO, Daneshvar B, Pulido R, Saura-Calixto F. (PubMed)
(2) Leaf parts from Greek artichoke genotypes as a good source of bioactive compounds and antioxidants by Petropoulos SA1, Pereira C, Barros L, Ferreira ICFR. (PubMed)
(3) Western-Style Diets Induce Oxidative Stress and Dysregulate Immune Responses in the Colon in a Mouse Model of Sporadic Colon Cancer by Ildiko Erdelyi,4 Natasha Levenkova,5 Elaine Y. Lin,8 John T. Pinto,9 Martin Lipkin,4Fred W. Quimby,6 and Peter R. Holt. (PMC)
Scientists may have found a herbal remedy that processed significant antioxidant activity against the onset and progression of oxidative stress-related diseases, according to studies.
Oxidative stress-related conditions are the class of diseases associated with cellular damage, including the alternation of cell DNA, and damage of lipids and proteins.
The list of chronic diseases caused by cell oxidation is very long, including atherosclerosis, cancer, diabetes, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.
The most common causes of oxidative stress are overexpression of free radicals in the induction of a chain reaction.
Due to the unstable nature of free radicals with unpaired electrons in the outer ring, free radicals are ready to donate or intercept the electrons from other atoms, leading to a chain reaction that can not be stopped until the outring electron are either paired or inhibited by antioxidants.
In contrast to the general belief, the damage caused by free radicals is overly exaggerated, under normal conditions, free radicals produced by internal or external sources are needed by our body for cellular responses and immune function.
However, overexpression of free radicals also known as oxidative stress can be a danger to our health.
Oxidative stress can be acute or chronic. Acute oxidative stress is caused by a sudden burst of free radicals due to stress or external sources, in most cases can be inhibited by increasing antioxidant enzymes in the lung.
Chronic oxidative stress is caused by the unbalanced ratio of free radicals and antioxidant enzymes produced by our bodies. The condition is either caused by overexpression of free radicals or depletion of antioxidants enzymes or both.
There are many risk factors that cause oxidative stress. However, in the concerns of the prevalence of chronic diseases associated with the Western diet, some researchers suggested that the link of oxidative diseases in the Western world may result from the promotion of the Western diet over the past few decades.
Dr. Ildiko Erdelyi, the lead scientist said, "A Western-style diet (WD), defined by high-fat, low-calcium, and vitamin D content, is associated with increased risk of human colorectal cancer. Understanding molecular mechanisms altered by the WD is crucial to develop preventive and therapeutic strategies".
And, "consumption of a WD interferes with networks of related biological response pathways involving colonic lipid metabolism, oxidative stress, and the immune response".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Scientists on finding a natural ingredient for the treatment of oxidative stress-related diseases examined the antioxidant activity of artichokes in the rat model.
Artichoke extracts showed good efficiency in the inhibition in vitro of LDL oxidation. Injection of artichoke extracts also increased the levels of antioxidant glutathione peroxidase against oxidative damage in the tested subjects compared to the control group.
Injection of artichoke extracts also inhibited the expression of a protein oxidation biomarker (2-Aminoadipic semialdehyde) compared to the control group.
In order to reveal more information on artichoke antioxidant activity, researchers examined the phenolic compound content and composition and the antioxidant activity of leaf parts [blades (SLB), petioles, and midribs (SPM)] from various Greek artichoke genotypes.
Most of the genotypes' leaf blades had a high flavonoid content (mainly luteolin glycoside derivatives), which ranged between 49 and 78% of total phenolic compounds (TPC).
Petioles and midribs phenolic acids (mainly hydroxycinnamic acid derivatives) were the main phenolic compounds, ranging between 64 and 76% of TPC,
The antioxidant activity of blades was significantly higher than that of petiole and midribs for all the genotypes according to the tested assays.
The results of antioxidant differentiation suggested that artichoke leaves (blades, petioles, and midribs) show different bioactive compound profiles in stimulating the different antioxidant properties.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of oxidative stress-related diseases through its antioxidant activity, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) In vitro antioxidant activities of edible artichoke (Cynara scolymus L.) and effect on biomarkers of antioxidants in rats by Jiménez-Escrig A1, Dragsted LO, Daneshvar B, Pulido R, Saura-Calixto F. (PubMed)
(2) Leaf parts from Greek artichoke genotypes as a good source of bioactive compounds and antioxidants by Petropoulos SA1, Pereira C, Barros L, Ferreira ICFR. (PubMed)
(3) Western-Style Diets Induce Oxidative Stress and Dysregulate Immune Responses in the Colon in a Mouse Model of Sporadic Colon Cancer by Ildiko Erdelyi,4 Natasha Levenkova,5 Elaine Y. Lin,8 John T. Pinto,9 Martin Lipkin,4Fred W. Quimby,6 and Peter R. Holt. (PMC)
#Curcumin Found in #Turmeric Exerts Protection Against #SkinAging and Disorders such as #Psoriasis, #Infection, #Acne, #Inflammation, and #SkinCancer, Researchers Find
Kyle J. Norton
Skin, a large external organ in the human body is the outer layer, with a total area of about 20 square feet which protects the internal organs, bones, and tissues against damage.
The skin processes 3 main layers
* Epidermis is the outer most layer of the skin providing a barrier against infection from environmental pathogens. The outer layers also regulate the amount of water released from the body through transepidermal water loss.
* Dermis is the second layer of skin, containing blood capillaries, nerve endings, sweat glands, hair follicles, and other structures.
* The bottom layer is the subcutaneous fat which has been found to process the protective effect against the dangers of visceral fat.
Skin health refers to the use of material or agents, including topical and oral herbal remedies with the function to protect the skin cell against the environment's harmful substances, including the sun's UV light, and microbial infection.
Some researchers suggested that by providing enough nutrition to the skin cells we can maintain healthy skin. In other words, macronutrients including carbohydrates, proteins, and lipids, and micronutrients such as vitamins and essential minerals all work together to maintain healthy skin.
More precisely, we can maintain healthy skin by eating a healthy diet accompanied by moderate exercise and avoiding exposure of skin to harmful substances.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural compound for the enhancement of skin health, researchers examined the active component of turmeric, curcumin used medically to treat a variety of dermatologic diseases in traditional medicine.
The search involved the relationship between products containing turmeric, curcumin, and skin health in the medical databases of PubMed and Embase databases and found a total of 234 articles with only 18 studies that met inclusion criteria.
According to the identified studies, ingestion, topical use, and combined ingestion and topical use showed a statistically significant improvement in skin disease severity in the turmeric/curcumin treatment groups compared with control groups, including conditions of acne, alopecia, atopic dermatitis, facial photoaging, oral lichen planus, pruritus, psoriasis, radiodermatitis, and vitiligo.
Dr. Vaughn AR, the lead scientist after taking into account co and confounder wrote in the final report, "Overall, there is early evidence that turmeric/curcumin products and supplements, both oral and topical, may provide therapeutic benefits for skin health".
In order to reveal more information about curcumin in skin protection, researchers investigated the antioxidative, anti-inflammatory, and antibacterial properties against skin diseases.
According to the tested assays, curcumin exerted protective effects against skin damage caused by chronic ultraviolet B radiation.
Curcumin application also has a strong effect on the protection against skin aging and disorders such as psoriasis, infection, acne, skin inflammation, and skin cancer.
Taken altogether, turmeric may be considered a supplement for skin health with no side effects, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence by Vaughn AR1, Branum A2, Sivamani RK. (PubMed)
(2) Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review by Panahi Y1, Fazlolahzadeh O2, Atkin SL3, Majeed M4, Butler AE5, Johnston TP6, Sahebkar A. (PubMed)
Skin, a large external organ in the human body is the outer layer, with a total area of about 20 square feet which protects the internal organs, bones, and tissues against damage.
The skin processes 3 main layers
* Epidermis is the outer most layer of the skin providing a barrier against infection from environmental pathogens. The outer layers also regulate the amount of water released from the body through transepidermal water loss.
* Dermis is the second layer of skin, containing blood capillaries, nerve endings, sweat glands, hair follicles, and other structures.
* The bottom layer is the subcutaneous fat which has been found to process the protective effect against the dangers of visceral fat.
Skin health refers to the use of material or agents, including topical and oral herbal remedies with the function to protect the skin cell against the environment's harmful substances, including the sun's UV light, and microbial infection.
Some researchers suggested that by providing enough nutrition to the skin cells we can maintain healthy skin. In other words, macronutrients including carbohydrates, proteins, and lipids, and micronutrients such as vitamins and essential minerals all work together to maintain healthy skin.
More precisely, we can maintain healthy skin by eating a healthy diet accompanied by moderate exercise and avoiding exposure of skin to harmful substances.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural compound for the enhancement of skin health, researchers examined the active component of turmeric, curcumin used medically to treat a variety of dermatologic diseases in traditional medicine.
The search involved the relationship between products containing turmeric, curcumin, and skin health in the medical databases of PubMed and Embase databases and found a total of 234 articles with only 18 studies that met inclusion criteria.
According to the identified studies, ingestion, topical use, and combined ingestion and topical use showed a statistically significant improvement in skin disease severity in the turmeric/curcumin treatment groups compared with control groups, including conditions of acne, alopecia, atopic dermatitis, facial photoaging, oral lichen planus, pruritus, psoriasis, radiodermatitis, and vitiligo.
Dr. Vaughn AR, the lead scientist after taking into account co and confounder wrote in the final report, "Overall, there is early evidence that turmeric/curcumin products and supplements, both oral and topical, may provide therapeutic benefits for skin health".
In order to reveal more information about curcumin in skin protection, researchers investigated the antioxidative, anti-inflammatory, and antibacterial properties against skin diseases.
According to the tested assays, curcumin exerted protective effects against skin damage caused by chronic ultraviolet B radiation.
Curcumin application also has a strong effect on the protection against skin aging and disorders such as psoriasis, infection, acne, skin inflammation, and skin cancer.
Taken altogether, turmeric may be considered a supplement for skin health with no side effects, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence by Vaughn AR1, Branum A2, Sivamani RK. (PubMed)
(2) Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review by Panahi Y1, Fazlolahzadeh O2, Atkin SL3, Majeed M4, Butler AE5, Johnston TP6, Sahebkar A. (PubMed)
Subscribe to:
Posts (Atom)