#Tomato #Lycopeneextract (TLE) Blocks the Inhibition of the Protein Involved in Cytokine Production Associated with the Risk of #Colitis

Kyle J. Norton

Colitis is chronic a condition associated with the inflammation of the large intestine, including the colon, caecum, and rectum.

Colitis can be classified into microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis(a), according to the Catholic University of the Sacred Heart.

The most common symptoms of colitis are totally depending on the type. However, the general symptoms include

* Adnominal pain and diarrhea
There is a report of a 25-year-old Iranian gentleman who was admitted to the hospital with severe bloody diarrhea and abdominal pain as a result of herbal-induced weight loss adverse effects. On flexible sigmoidoscopy, a continuous length of congested mucosa with multiple small ulcers was seen extending up to the mid-transverse colon, in keeping with ulcerative colitis, according to the study by
Homerton University Hospital NHS Foundation Trust(1)

2. Bleeding per rectum
Acute ischaemic colitis (AIC) is being increasingly recognized as an uncommon cause of abdominal pain associated with fresh bleeding per rectum and diarrhea, according to the study by University Central Hospital(2).

3. Distention with bloody diarrhea
The typical clinical presentation is acute sudden abdominal pain and distention with bloody diarrhea(3).

4. Abdominal bloating and flatulence
In the study to estimate the prevalence of microscopic colitis and SIBO in patients with IBS, to evaluate the symptoms and the efficacy of treatment found that out of the 132 patients initially diagnosed with IBS 3% (n=4) had microscopic colitis and 43.9% (n=58) had SIBO. Diarrhea was the main symptom in patients with microscopic colitis and SIBO (p=0.041), while abdominal pain, abdominal bloating, and flatulence were prominent in IBS patients (p=0.042; p=0.039; p=0.048)(4).

5. Changes in bowel habits
Abdominal pain, bloating, early satiety, and changes in bowel habits are common presenting symptoms in individuals with functional GI disorders(5).

6. Fever and severe dehydration
There is a report of a 19-year-old man with a 1-year history of ulcerative colitis presented with fever, bloody diarrhea, and severe dehydration. He was on po.48 mg methylprednisolone and 3 g mesalazine daily and has recently finished taking clarithromycin for Campylobacter jejuni infection(6).

7. Urgency
The study to examine the differing perspectives and perceptual gaps relating to ulcerative colitis (UC) symptoms and their management between patients and healthcare professionals (HCPs), indicated that fifty-five percent of patients stated that UC symptoms over the past year had affected their quality of life, while physicians and nurses estimated that 35% to 37% of patients would have a reduced quality of life over the same period. Patients ranked urgency and pain as the most bothersome symptoms(7)

8. Other symptoms
There is a report of a case of a 51-year-old Caucasian male who was evaluated for abdominal pain, elevated liver enzymes, leukopenia, thrombocytopenia, severe peripheral arthralgias, and chronic watery diarrhea as a result of granulomatous enterocolitis. due to Sarcoidosis(8). Another study conducted by Anhui University of Traditional Chinese Medicine, with rats in the model group, showed lethargy, poor appetite, loss of energy, diarrhea, and bloody stool(9).

If you have experienced some of the aforementioned symptoms persistently with no signs of stopping, please make sure you check with your doctor to rule out the possibility of colitis.

Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

In finding healthy foods for the treatment of colitis, researchers examined the impact of tomato lycopene extract (TLE) on intestinal inflammation.

The study included mice lipopolysaccharide (LPS)-induced innate signaling and experimental colitis fed a diet containing 0.5 and 2% TLE or isoflavone-free control (AIN-76).

According to the tested assays, TLE blocked LPS-induced IkappaBalpha degradation and RelA translocation associated with the onset of colitis by blocking the inhibition of the protein involved in cytokine production.

Furthermore, MIP-2, a small cytokine mRNA accumulation in IEC-18 cells, and pro-inflammatory cytokine Interleukin 12 (IL-12) induced by LPS were inhibited by the injection of TLE.

Moreover, the application of TLE also increased the expression of anti-inflammatory cytokines IL-6, TNF-alpha, a regulator of inflammation, and MCP-1 mRNA associated with macrophage recruitment in the colon of TLE-fed subjects.

The results strongly suggested that tomato extract inhibited colitis in mice through its modulatory of immune and inflammatory activity.

Taken altogether, tomatoes may be considered a dietary supplement for the prevention and treatment of colitis, pending to large sample size and multicenter human study.


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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice by Joo YE1, Karrasch T, Mühlbauer M, Allard B, Narula A, Herfarth HH, Jobin C. (PubMed)
(2) Colitis - Types and Symptoms by Kyle J. Norton

#Carotenoid Functionalized Dendritic Nanoparticles (CDN) Inhibit the Expression of Transcription Factors That Cause LiverDiseases

By Kyle J. Norton

Liver cancer is a medical condition caused by irregular cell growth in the liver tissue due to the alternation of the cell's DNA.

The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above your stomach.

Since the organ is a soft tissue with fewer nerves, most liver cancer patients are diagnosed in the later stage of cancer.

Liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

According to the statistic, approximately 42,030 adults (29,480 men and 12,550 women) in the United States will be diagnosed with primary liver cancer in 2019 in the US.

Believe it or not, since 1980, the incidence of liver cancer has tripled. Between 2006 and 2015, the number of people diagnosed with the disease increased by approximately 3% annually.


The exact causes of liver cancer are not identified. However, epidemiologically, age, gender, geography, cirrhosis (severe scarring in the liver), and medical conditions such as diabetes and obesity are some of the most common prevalent factors associated with liver cancer developing.


Some researchers suggested the increased liver cancer incidence may be associated with the promotion of a high-fat diet over the past few decades.

Dr. VanSaun MN, the lead scientist wrote, "Chronic changes induced by the prolonged consumption of a high-fat diet alone culminate in the development of primary liver dysplasias".

And, "High-fat diet-induced steatosis, coupled with a splenic injection model of experimental liver metastasis using syngeneic MC38 colon cancer cells, resulted in an increased number of secondary tumor nodules and metastatic burden in steatotic livers. Metastatic nodules were associated with focal peritumoral areas of infiltrating inflammatory cells and associated apoptotic cell populations".

Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.

In finding a potential ingredient for the treatment of liver cancer researchers examined the carotenoid's effects on hepatocellular carcinoma (HCC) progression.

According to the tested results of the delivery of siFOXC1 using novel carotenoid functionalized dendritic nanoparticles (CDN), the CDN not only displayed a markedly reduced toxicity profile but also achieved ∼90% FOXC1 knockdown.

In other words, the established delivery CDN inhibited the expression of transcription factor FOXC1 which has been found to induce hepatocellular carcinoma (HCC) progression.

Including carotenoids, the CDN achieves  ∼18% greater delivery efficiency compared to treatments of particles with no carotenoid tagging.

Researchers after taking other factors into account said, "thereby emphasizing the role of carotenoid mediated cell internalization in the efficient delivery of CDN-siFOXC1 complex in liver cancer cells".

More precisely, using the aforementioned delivery system, carotenoids are more effective in the inhibition of liver cancer compared to oral injection.

Taken altogether, carotenoids may be considered a remedy for the prevention and treatment of liver cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of carotenoids in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Carotenoid Nanovector for Efficient Therapeutic Gene Knockdown of Transcription Factor FOXC1 in Liver Cancer by Misra SK1, Ray T2, Ostadhossein F1, Kim B2, Ray PS2, Pan D. (PubMed)
(2) High fat diet-induced hepatic steatosis establishes a permissive microenvironment for colorectal metastases and promotes primary dysplasia in a murine model by VanSaun MN1, Lee IK, Washington MK, Matrisian L, Gorden DL. (PubMed)

#Phytochemical #Betanin Inhibits Reactive Oxidative Species (ROS) Associated with the Onset of #ChronicDiseases, Researchers Find

By Kyle J. Norton

Reactive oxidative species or ROS are chemically reactive atoms containing oxygen
In other words, ROS includes a number of reactive molecules and free radicals derived from molecular oxygen, including peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen.

Free radicals used to interchange with ROS with unstable nature are atoms with an unpaired electron in the outermost ring. Therefore, in order for them to maintain stability, free radicals must intercept or donate an electron to or from the stable atoms respectively, leading to a domino effect that can not be stopped until all outermost ring electrons are paired or inhibited by antioxidants.

Long-term overexpression of free radicals compared to antioxidants can result in oxidative stress, a leading cause of protein, lipid and cellular damage.

Believe it or not, free radical levels in a moderate amount are necessary to enhance the body's functioning, including vascular relaxation.

Balancing the ratio of free radicals and antioxidants may be the best way to avoid the development of chronic illness associated with oxidative stress.

However, long-term expression of oxidative stress has been found to induce several chronic diseases, including heart disease, stroke, diabetes, and cancer.


Dr. RC Petersen, the lead scientist wrote, "When O2 is absent during periods of intermittent hypoxia in mitochondrial energy synthesis, the generation of excess electrons can develop free radicals or excess protons can produce acid. Free radicals formed by limited O2 can damage lipids and proteins and greatly increase molecular sizes in growing vicious cycles to reduce oxygen availability even more for mitochondria during energy synthesis".


And, "Further, at adequate free-radical concentrations a reactive crosslinking unsaturated aldehyde lipid breakdown product can significantly support free-radical polymerization of lipid oils into rubbery gel-like solids and eventually even produce a crystalline lipid peroxidation with the double bond of O2".


The result clearly suggested developing free-radical inhibitors may some days be used for medical treatments in many pathologies such as cancer, atherosclerosis, diabetes, infection/inflammation and also aging.

Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to discover a potential ingredient for the inhibition of the expression of free radicals, researchers examined the effect of betanin, one of the beetroot's major components, on ROS production.

In vitro, incubation of neutrophils with betanin in the concentration range 2-500 µM showed a significant reduction of ROS production by 15-46%, depending on the ROS detection assay and increase of antioxidant capacity.

Furthermore, betanin did not affect caspase-3 activity in programming cell death, in resting neutrophils, but significantly enhanced the antioxidant enzyme activity in stimulated neutrophils.


In other words, betanin inhibited the free radical activity in the initiation of cytotoxicity through its antioxidant activity.

Based on the findings, researchers wrote, "The results indicate that betanin may be responsible for the effect of beetroot products on neutrophil oxidative metabolism and its consequences".

In organophosphates (OP), a pesticide commonly utilized in agricultural and domestic use, side effects in different body tissues, researchers conducted a joint study led by the Maragheh University of Medical Sciences, to assess whether betanin (a natural pigment) is able to mitigate some OPs-induced hepatotoxicity in primary rat hepatocytes.

According to the outcome, betanin (25μM) significantly increased cell viability, plummeted ROS formation and LPO and restored cellular GSH reservoirs.

Betanin (25μM) not only protects the body tissue against the overexpression of free radicals induced by OP but also prevents the expression of oxidative stress in the liver tissues by stimulating the production of the antioxidant enzyme from the host.

Dr. Ahmadian E, the lead scientist wrote, "The potential protective role of betanin in OPs-induced hepatotoxicity in which the mechanism appears to be inhibition of ROS formation and mitochondrial protection".

Taken altogether, betanin may be considered a supplement for preventing the overexpression of ROS, pending the confirmation of a larger sample size and multicenter human study.

Intake of betanin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The beetroot component betanin modulates ROS production, DNA damage and apoptosis in human polymorphonuclear neutrophils by Zielińska-Przyjemska M1, Olejnik A, Kostrzewa A, Łuczak M, Jagodziński PP, Baer-Dubowska W. (PubMed)
(2) Betanin reduces organophosphate induced cytotoxicity in primary hepatocytes via an anti-oxidative and mitochondrial-dependent pathway by Ahmadian E1, Khosroushahi AY2, Eghbal MA3, Eftekhari A. (PubMed)
(3) Advancements in Free-Radical Pathologies and an Important Treatment Solution with a Free-Radical Inhibitor by RC Petersen,1,* MS Reddy,2 and P-R Liu. (PMC)

#Yoga In the Relief of #Severity of HYeadache, Duration & Frequency of Chronic Headache, Clinical Trials Suggest

By Kyle J. Norton

Yoga therapy may have an important role in regulating central versus peripheral mechanisms in the expression of chronic headaches, the study by the All India Institute of Medical Sciences suggested.

Yoga, the ancient practical technique for harmonizing external and internal body well beings, through breath control, meditation, bodily movement, and gesture..... has been best known to people in the Western world and some parts of Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

According to the study to investigate the role of muscle spasm overactivity in chronic tension-type headache (CTTH) with 15 patients of CTTH and 7 age-matched controls, randomized assigned to either yoga intervention or control, the yoga group demonstrated a significant improvement in reduced overactivity of the temporalis muscle in CTTH patients at rest in compared with control.


Furthermore after examined the EMG records, researchers found that yoga group displayed a substantial decrease in the mean electromyography (EMG) amplitude of temporalis muscle during rest and mental activity in compared to other applications such as nonsteroidal anti-inflammatory drugs, botulinum toxin injections, and improved subjective pain scores.

EMG amplitude is a medical technique in the evaluation of details of the timing and magnitude of muscle activation for many muscles powering a variety of types of locomotion.

Truly, yoga breathing and relaxation reduced daily stress by calming the central nervous system by connecting the mind and body, restoring the endocrine system in hormone balancing, thus reducing the production of the stress hormone cortisol by bringing back the present moment, while letting them go or dealing them in a profound way.

Furthermore, yoga postures and deep breathing ameliorated overexpression of nerve neurons in transmitted information of sensation, stress, and suffering by creating a state of ease of the body and mind, and strengthening the flow of energy, thus enhancing relaxation response to pain through unraveling the mind-body sanskaras.

Another study is conducted on 50 patients (aged 18-58 years) with the clinical diagnosis of CCTH, divided into 2 groups. with group 1 (n=30) received 8 lessons and practical demonstration of Brahmakumaris spiritual-based meditation known as Rajyoga meditation for relaxation therapy, in addition to routine medical treatment (analgesics and muscle relaxants) and group 2 (n=20) patients received analgesics and muscle relaxants twice a day but no relaxation therapy in the form of meditation by the Dr. Kiran, and colleagues, to support of the effect of yoga therapy in reduced symptoms and pain in tension types of headache, after 8 weeks follow up period, scientists showed that both therapies showed a highly significant reduction in headache variables but yoga group expressed a highly significant relief of severity, duration & frequency of headache in Group 1 by 94%, 91% and 97% in compared to group 2 of 36%, 36%, and 49% respectively.

The total headache relief according to the headache index was 99% in the yoga group in compared to 51% in control group.

These results indicated that yoga intervention may have an acute effect in ameliorated pain in chronic tension headache.

More promisingly, in the study to provide preliminary data on the feasibility, acceptability, and safety of alignment-based yoga for youths with chronic headaches researchers at the joint study led by the Medical College of Wisconsin/Children's Hospital of Wisconsin found that yoga therapy may be considered pediatric headaches treatment indicated by positive parent and participant ratings of the yoga experience.

Indeed, some yoga instructors suggested that the alleviation of stress-induced insomnia and swelling and constriction of the blood vessels of yoga exercise in the initiation of deep sleep and in reduced tension of the blood vessels in the face and neck may also decrease pain through head muscles relaxation and revitalization and improved hypertension in blood circulation, particularly in people with chronic headache.

The findings suggested that yoga intervention may be used as an integrated form of exercise in provided relief in the severity of headache, duration & frequency of chronic headache, particularly in tension types of headache.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources(1) Role of temporalis muscle over activity in chronic tension type headache: effect of yoga based management by Bhatia R1, Dureja GP, Tripathi M, Bhattacharjee M, Bijlani RL, Mathur R.(PubMed)
(2) Effect of rajyoga meditation on chronic tension headache by Kiran, Girgla KK, Chalana H, Singh H.(PubMed)
(3) A pilot study of yoga for chronic headaches in youth: promise amidst challenges by Hainsworth KR1, Salamon KS2, Khan KA3, Mascarenhas B4, Davies WH2, Weisman SJ3.(PubMed)
(4) Interpreting muscle function from EMG: lessons learned from direct measurements of muscle force byThomas J. Roberts1,* and Annette M. Gabaldón(PMC)

#Herbal #Bilberry Inhibits the Parameters Associated with the Risk of #CardiovascularDisease (#CVD), According to Clinical Trials

By Kyle J. Norton

Cardiovascular disease is a general term for diseases associated with the blood vessels and heart, including coronary artery diseases (CAD) affected by obstruction of arteries and stroke affected by the capillaries in the brain.

In other words, the disease in CVD varies depending on the affected locations. Atherosclerosis is also the most common cause of cardiovascular disease.

The exact causes of CVD are not clear. However, high blood pressure, smoking, diabetes mellitus, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol consumption, are found to be associated with an increased risk of CVD.

According to the statistics provided by the American Heart Association, over 84 million people in the US suffer from some form of cardiovascular disease, causing the death of 2,200 people a day.

Sadly, approximately 15 million U.S. adults have coronary heart disease.

Out of many risk factors, some researchers suggested that high blood pressure found in 103 million U.S. adults one of the major causes of CVD. Believe it or not, approximately 54% of strokes and 47% of coronary heart diseases, worldwide, are attributable to high blood pressure.

Dr. Chen-Yi Wu, the lead scientist said, "The cardiovascular and expanded-cardiovascular mortality risks were lowest when systolic blood pressures were 120 to 129 mm Hg, and increased significantly when systolic blood pressures (SBPs) were ≥160 mm Hg or diastolic BPs were ≥90 mm Hg".

And, " The impacts of stage 2–3 hypertension on mortality risks were significantly increased among women. The mortality risks of hypertension were not attenuated with older age".


Bilberry is a species of low-growing shrub in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as an herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer,

In the urgency to find a natural ingredient for the prevention of cardiovascular diseases (CVD), a leading cause of death researchers examined the bilberry's beneficial effects on CVD risk reduction.

The study included women (n=25) and men (n=11) who consumed 150 g of frozen stored bilberries 3 times a week for 6 weeks.

According to the tested assays, consumption of bilberries showed a decrease in total cholesterol, LDL-C, TG, glucose, albumin, γ-glutamyltransferase, and a positive increase in HDL-C.


All parameters associated with the risk of CVD were decreased substantially at the end of the study. In other words, bilberry reduced the risk of CVD by promoting the blood flow to the heart and other parts of the body.

Interestingly, in men, favorable changes were observed in total cholesterol, glucose, albumin, aspartate aminotransferase, γ-glutamyltransferase, and HDL-C compared to women.

The results strongly support the regular use of bilberries as a dietary fruit source to reduce the CVD risk, by decreasing LDL-C/TG and increasing HDL-C.

Dr. Habanova M, after taking into account co and confound wrote in the final report, "Changes in other parameters were not significant, for both women and men. Thus, the regular intake of bilberries can be important to reduce CVDs risk, by decreasing LDL-C/TG and increasing HDL-C".

Taken altogether, bilberry may be considered a functioning remedy for the prevention of cardiovascular diseases (CVD), pending the validation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles by Habanova M1, Saraiva JA2, Haban M3, Schwarzova M4, Chlebo P5, Predna L6, Gažo J7, Wyka J. (PubMed)
(2) A Brief Review of Blue- and Bilberries' Potential to Curb Cardio-Metabolic Perturbations: Focus on Diabetes by Crespo MC1, Visioli F. (PubMed)
(3) High Blood Pressure and All-Cause and Cardiovascular Disease Mortalities in Community-Dwelling Older Adults by Chen-Yi Wu, MD, Ph.D., Hsiao-Yun Hu, Ph.D., Yiing-Jenq Chou, MD, Ph.D., Nicole Huang, Ph.D., Yi-Chang Chou, MS, and Chung-Pin Li, MD, Ph.D. (PMC)

#Healthyfood #Cucumber's #Cucurbitacin B (CuB) Processes Anti-#SkinCancer Cells' Proliferation in Vitros

By Kyle J. Norton

Skin cancer is a chronic and medical caused of cell growth disorderly and uncontrollably due to the alternation of DNA. 

Most cases of skin cancer begin in the cells on the surface of the inner lining, before proliferating to other tissues through cell cycle division.

Compared to normal cells with a limit of cycle division, the cancer cell can divide indefinitely. Some tumors can also stimulate the production of new vessels to provide them with additional energy from the preexist vessel.

The most common types of skin cancer are
* Basal cell cancer
It is the most common type of skin cancer as a result of abnormal growth of the cells in the lowest layer of the epidermis, accounting for more than 90% of all skin cancer in the U.S.

* Squamous cell cancer
Squamous cell cancer arises from the uncontrolled multiplication of transformed malignant cells in the middle layer of the epidermis.

* Melanoma
Melanoma is a result of malignancy of melanocytes, which are the cell produced dark pigment for your skin.

The most common symptoms of skin cancer are abnormal skin patches, such as flat, scaly, brown or flesh-colored patches, a white, waxy scar-like sore, scaly red skin lesion, skin bump or lump, sore that won't heal, unintentional weight loss and non-healing ulcer, especially on lip or ears.

If you are experiencing some of the above symptoms, please make sure you check with your doctor to rule out the possibility.

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound that processes anti-skin cancer properties, researchers investigated the cucurbitacin B (CuB) effect, a major compound found in cucumber on cutaneous squamous cell carcinoma (CSCC).

According to the tested analysis, CuB inhibited 50% growth (ED50) of the CSCC cell lines (SRB1, SRB12, SCC13, COLO16) in liquid culture at 4 x 10(-7)-10(-5) M.

At 10(-7) M, CuB inhibited nearly all of the CSCC clonogenic cells used in the study through cell cycle arrest.

Interestingly, injection of Cub exerted cancer cell morphologic changes within 60 min. Moreover, Cub (10(-8)-10(-6) M, 3-24 h) was effective in inhibiting the proteins associated with SRB1 and SRB12 cell lines proliferation by disrupting the cell cycle division.

The migration of SRB1 and SRB12 cells was also suppression by the injection of 10(-7) M CuB.

Most importantly, CuB exerted the synergistic potentiation of the anti-proliferative effect of cisplatin in CSCC.

In other words, CuB suppressed the cancer cell progression linearly in a dose-dependent manner through its G2/M cell cycle arrest

Based on the findings, researchers wrote, "CuB has a prominent anti-proliferative activity on CSCC cells".

Taken altogether, cucumber processed with a high amount of CuB may be used for the treatment of skin cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cucurbitacin B inhibits growth, arrests the cell cycle, and potentiates antiproliferative efficacy of cisplatin in cutaneous squamous cell carcinoma cell lines by Chen W1, Leiter A, Yin D, Meiring M, Louw VJ, Koeffler HP. (PubMed)

The Effects of #Coffee and #CoffeeCaffeine Intake on #Gallstones and #GallstoneDiseases, According to Clinical Trials

By Kyle J. Norton

Epidemiological studies, linking coffee consumption to reduce the risk of gallstone, but not gallstone disease have been contradictory.
Gallstone is a stone formed within the gallbladder out of bile components as a result of the building up of undissolved cholesterol over a prolonged period of time.

Coffee is a popular and social beverage all over the world, particularly in the West, made from roast bean from the coffee plant, native to tropical Africa and Madagascar.

In the review of 174 cases of gallstones determined by ultrasonography, 104 cases of postcholecystectomy, and 6889 controls of normal gallbladder in the total of 7637 men received a health examination at four hospitals of the Self-Defense Forces (SDF) with 174 cases of prevalent gallstones, 50 had been aware of having gallstones, researchers found that coffee and coffee caffeine drinkers express a high risk of gallstone incidence compared to non drinkers.

In this group of middle-aged Japanese men, the relative odds ratio of gallstone disease is 1.7 for coffee consumption of five cups or more per day vs. no consumption and 2.2 for caffeine intake of 300 mg/day or more vs. less than 100 mg/day.

Obviously, these findings contradicted other studies in support of the risk of gallstones reduced by coffee and caffeine intake, including the study conducted by the Harvard School of Public Health.

Other, in the review literature of database from PubMed and EMBASE of all published studies before June 2015 researchers at The First Affiliated Hospital of Zhengzhou University files the following results
1. Coffee intake regularly and daily had a significantly reduced risk of gallstone disease, in related females, but not in males. based on prospective studies.

2. For patients drinking one cup of coffee per day, the risk of gallstone disease was 0.95
3. For patients drinking 2, 4, and 6 cups of coffee per day, the estimated RRs of gallstone disease reduced to 0.89 (95% CI, 0.79 to 0.99), 0.81, and .75 respectively.
4, Coffee intake showed a linear association to the ameliorated risk of gallstone diseases.


Interestingly, in a cohort of 80,898 women aged 34-59 years in 1980 who had no history of gallstone disease, during 20 years of follow-up, researchers filed the below results
1. Compared to noncaffeine coffee drinkers women, the multivariate relative risks of gallstone disease with cholecystectomy in compared to a consistent intake of caffeinated coffee (0, 1, 2-3, and > or =4 cups/day) were 1.0, 0.91, 0.78, and 0.72 respectively.
2. Coffee caffeine intake was inversely associated with the risk of cholecystectomy.
3. Caffeine intake (< or =25, 26-100, 101-200, 201-400, 401-800, and >800 mg/day) is linearly associated with a reduced risk of gallstone disease with the multivariate relative ratio of 1.0, 1.03, 1.01, 0.94, 0.85, and 0.85 4. Decaffeinated coffee was not associated with risk.

There is no doubt that the study addresses a significantly inverse association in reduced risk of gallstone disease among coffee drinkers linearly.

Taking all together, the contradictory result may warrant a further study before one can make a decision on the effect of coffee and coffee caffeine in concern of risk of gallstone, but not in the attenuated risk of symptomatic gallstone disease.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Relation of coffee, green tea, and caffeine intake to gallstone disease in middle-aged Japanese men by Ishizuk H1, Eguchi H, Oda T, Ogawa S, Nakagawa K, Honjo S, Kono S.(PubMed)
(2) Systematic review with meta-analysis: coffee consumption and the risk of gallstone disease by Zhang YP1, Li WQ1, Sun YL1, Zhu RT1, Wang WJ1.(PubMed)
(3) A prospective study of coffee consumption and the risk of symptomatic gallstone disease in men by Leitzmann MF1, Willett WC, Rimm EB, Stampfer MJ, Spiegelman D, Colditz GA, Giovannucci E.(PubMed)