The #Soyfood Effects on the Risk of #Cancers in Japanese

Kyle J. Norton

Soybean is the genus Glycine, belonging to the family Fabaceae, one of the legumes that contains twice as much protein per acre as any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with a suitable climate for commercial profits.

Japan, an island nation in the Pacific Ocean, lies to the east of the Sea of Japan, China, North Korea, South Korea, and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south(1c). According to Moriyama, Japanese women and men live longer and healthier than everyone else on Earth, it may be a result of a healthier Japanese diet and lifestyle. According to the World Health Organization, the Japanese have an average of 75 years of healthy living disability-free, it may be due to average soy intake 10 to 70 times higher than in Western people(1a)(1b).

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, become progressively worse and damage other healthy tissues and sometimes spread to other organs in the body via lymph or blood and results may be in death.

Epidemiological studies, linking soy and soy products in reduced risk and treatment have been contradictive(1)(2)(3)(4), but in the Japanese population, soy and its products have been found effective in reducing the risk of and treatment of cancers, it may be a result of equol-producer status or long term exposure since childhoods. Some researchers suggested that it may be a result of the traditional Japanese diet high in soy, vegetables, and fish.

1. Breast cancer
Breast cancer (malignant breast neoplasm) is cancer that started in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) which supply the ducts with milk. 

There are also rare cases that breast cancer starts in other areas of the breast.

According to the evaluation based on a systematic review of epidemiologic evidence among the Japanese population, there is no association between the intakes of individual soy foods with the risk of breast cancer but evidence supported the biological plausibility of a protective effect of isoflavones on breast cancer risk(5). 

The study in the testing of oral administration of IF-rich tablets (20 and 40 mg/day) on climacteric women, showed the product not only reduced the risk of breast cancer but also improved bone density, hypertension, and climacteric symptoms, cardiovascular diseases, gynecological problems and possible immune potentiation(6).

Japanese women have a lower incidence of and mortality from breast cancer, compared to Caucasians, it may be a result of a large amount intake of soy protein and isoflavones, as a high dietary intake of phytoestrogens, mainly in the form of soy products, can produce circulating levels of phytoestrogens that are known experimentally to have oestrogenic effects(7).

2. Lung cancer
Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancer is derived from epithelial cells. In Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to 2007 statistics.

Soy intakes are associated with a reduced risk of lung cancer with epidermal growth factor receptor (EGFR) mutations which play substantial roles in the genesis and proliferation of non-small-cell lung cancers (NSCLCs), according to the Aichi Cancer Center Research Institute. (8). 

In Asian populations, not only Japanese, in the review of a total of 11 epidemiological studies that consisted of 8 case-control and 3 prospective cohort studies, although consumption of soy food is associated with lower lung cancer risk, intervention studies that use unified measures of soy intake are needed to fully characterize such an association due to different methods used to assess soy consumption across reviewed studies(9).

Indeed, isoflavone intake was associated with a decreased risk of lung cancer in never smokers, but not in current or past smokers, according to a population-based prospective cohort study in 36,177 men and 40,484 women aged 45-74 y with no history of cancer at baseline in 1995-1999, conducted by the National Cancer Center Tokyo Japan(10).

3. Bowel (Colorectal ) Cancer
Bowel cancer also known as colorectal cancer, is defined as a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. Bowl is divided into 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food.

 The 2nd part, the large bowel which consists of the colon and rectum, is involved in the absorption of water from the small bowel contents and breaking down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progresses cancer in a predictable way.

Bowel cancer is the third most commonly diagnosed cancer in developed countries, including the US and Canada.

The Research Center for Cancer Prevention and Screening, National Cancer Center in Japan, investigated the association between dietary soy and isoflavone intake and incidence of colorectal cancer in a prospective cohort study of 83,063 Japanese men and women, ages 45 to 74 years, intake of isoflavones, miso soup, and soy food was not associated with colorectal cancer in either men or women. By colorectal cancer subsite, the risk of proximal colon cancer in men decreased with increasing consumption of isoflavones, miso soup, and soy food Compared with men in the lowest quartiles of isoflavones(11), and high isoflavone intake was associated with reduced risk of CI and MI in Japanese women, especially in postmenopausal women(12).

But for patients with Acromegaly, a syndrome that results when the anterior pituitary gland produces excess growth hormone (GH), the risk of colorectal cancer is increased substantially(13)(14).

4. Gastric cancer
Stomach cancer is defined as a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.

According to the National Cancer Center, Goyang, Korea, a high level of consumption of non-fermented soy foods, rather than fermented soyfoods, is associated with reducing GC risk, in the reviews of 20 studies assessing the effect of the consumption of fermented soy food on GC risk(15).
4-hydroxy-2 (or 5)-ethyl-5 (or 2)-methyl-3(2H)-furanone (HEMF), a chemical constituent from Japanese-style fermented soy sauce, reduced hydrogen peroxide concentration in human polymorphonuclear leucocytes stimulated by arachidonic acid or 12-O-tetradecanoylphorbol-13-acetate, through inhibition of carcinogenesis in this system by acting at the post-initiation stage, in female rats(16). 

The long-term effect of shoyu (Japanese soy sauce), in the rat study, did not appear to be a carcinogen in the rat; its prolonged use impaired neither health nor longevity but with mild gastritis(17).

5. Cancer of Endometrium/Endometrial Cancer
The endometrium is the inner lining of the mammalian uterus and is very susceptible to hormone change, particularly in the menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition in which the cells of the endometrial lining of the uterus have growth uncontrollably or become cancerous as a result of the alternation of the cell's DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.

Greater consumption of isoflavone-containing foods is associated with a reduced risk of endometrial cancer in this population of non-hysterectomized postmenopausal women(18).
In support of the above, the University of Hawaii, in the study of Endometrial cancer cases (n = 332) diagnosed between 1985 and 1993 which were identified the five main ethnic groups in the state (Japanese, Caucasian, Native Hawaiian, Filipino, and Chinese) through the rapid-reporting system of the Hawaii Tumor Registry, showed that plant-based diets low in calories from fat, high in fiber, and rich in legumes (especially soybeans), whole grain foods, vegetables, and fruits reduce the risk of endometrial cancer(20). 

According to the National Cancer Center, Tokyo, Japan, in the study of Forty-nine thousand one hundred and twenty-one women of age 45-74 years who responded to a 5-year follow-up survey, researchers found that there was no evidence of a protective association between soy food or isoflavone intake and endometrial cancer risk(19).

6. Cervical Cancer
The cervix is the lower part of the uterus that opens at the top of the vagina. The cervix acts as a transition area for the vaginal lining (squamous epithelium) to change to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus. Cervical cancer is a malignant neoplasm of the cervix uteri or cervical area caused by abnormal cell growth with an alternation of the cell's DNA.

According to the study, there was a marginally significant inverse association between CIN3 and tofu and green leafy vegetables among Japanese women(21).

7. Prostate cancer
See The Science of Soy - The East Viewpoints: Part A3 - Soy and Prostate Cancer in Japanese Men

8. Thyroid Cancer
The thyroid is one of the largest endocrine glands found in the neck, below the Adam's Apple with the function of regulating the body's use of energy, make of proteins by producing its hormones as a result of the stimulation of thyroid-stimulating hormone (TSH) produced by the anterior pituitary.
Thyroid cancer is defined as a condition in which the cells in the thyroid gland have become cancerous.
According to the National Institute of Health Sciences, Tokyo, Japan, in the evaluation of the proliferating cell nuclear antigen labeling indices elevated in the ID diet(iodine-deficient diet) Female F344 rat groups suggest that isoflavones may not be involved in the mechanisms underlying the synergistic goitrogenic effect of soybean with iodine deficiency(22) but the study by showed the positive effect of dietary defatted soybean in synergistically stimulated the growth of rat thyroid with iodine deficiency, partly through a pituitary-dependent pathway(23). No study was found in the search of the keyword - soy and thyroid cancer in the Japanese population" in PubMed).

Taken altogether, Soy and its by-products may be associated with reduced risk and treating certain cancers in the Japanese population, including breast, lung, bowel, gastric, prostate, endometrial, and cervical cancers, etc. Due to the lack of qualities of the studies found in PubMed, further study may be necessary to improve its validation even in the Japanese population.



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Long-term exposure to dietary sources of genistein induces estrogen-independence in the human breast cancer (MCF-7) xenograft model by Andrade JE1, Ju YH, Baker C, Doerge DR, HelferichWG.(PubMed)
(2) Genistein stimulates the growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations by Ju YH1, Allred KF, Allred CD, Helferich WG. (PubMed)
(3) Daidzein-estrogen interaction in the rat uterus and its effect on human breast cancer cell growth by Gaete L1, Tchernitchin AN, Bustamante R, Villena J, Lemus I, Gidekel M, Cabrera G, Astorga P.(PubMed)
(4) The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein by Pabona JM1, Dave B, Su Y, Montales MT, de Lumen BO, de Mejia EG, Rahal OM, Simmen RC. (PubMed)
(5) Soy intake and breast cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population by Nagata C1, Mizoue T, Tanaka K, Tsuji I, Tamakoshi A, Matsuo K, Wakai K, Inoue M, Tsugane S, Sasazuki S; Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan(PubMed)
(6) Isoflavones for prevention of cancer, cardiovascular diseases, gynecological problems and possible immune potentiation by Watanabe S1, Uesugi S, Kikuchi Y.(PubMed)
(7) Phytoestrogens and breast cancer--promoters or protectors? by Rice S1, Whitehead SA.(PubMed)
(8) Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese by Matsuo K1, Hiraki A, Ito H, Kosaka T, Suzuki T, Hirose K, Wakai K, Yatabe Y, Mitsudomi T, Tajima K.(PubMed)
(9) Soy intake is associated with lower lung cancer risk: results from a meta-analysis of epidemiologic studies by Yang WS1, Va P, Wong MY, Zhang HL, Xiang YB. (PubMed)
(10) Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan by Shimazu T1, Inoue M, Sasazuki S, Iwasaki M, Sawada N, Yamaji T, Tsugane S; Japan Public Health Center-based Prospective Study Group. (PubMed)
(11) Dietary soy and isoflavone intake and risk of colorectal cancer in the Japan public health center-based prospective study by Akhter M1, Inoue M, Kurahashi N, Iwasaki M, Sasazuki S, Tsugane S; Japan Public Health Center-Based Prospective Study Group(PubMed)
(12) Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: the Japan Public Health Center-based (JPHC) study cohort I by Kokubo Y1, Iso H, Ishihara J, Okada K, Inoue M, Tsugane S; JPHC Study Group. (PubMed)
(13) The prevalence and associated factors of colorectal neoplasms in acromegaly: a single center-based study by Yamamoto M1, Fukuoka H, Iguchi G, Matsumoto R, Takahashi M, Nishizawa H, Suda K, Bando H, Takahashi Y.(PubMed)
(14) Risk of colorectal neoplasm in patients with acromegaly and its relationship with serum growth hormone levels by Matano Y1, Okada T, Suzuki A, Yoneda T, Takeda Y, Mabuchi H(PubMed)
(15) Fermented and non-fermented soy food consumption and gastric cancer in Japanese and Korean populations: a meta-analysis of observational studies by Kim J1, Kang M, Lee JS, Inoue M, Sasazuki S, Tsugane S.(PubMed)
(16) Inhibition of benzo[a]pyrene-induced mouse forestomach neoplasia and reduction of H2O2 concentration in human polymorphonuclear leucocytes by flavor components of Japanese-style fermented soy sauce by Kataoka S1, Liu W, Albright K, Storkson J, Pariza M.(PubMed)
(17) Long-term effect of shoyu (Japanese soy sauce) on the gastric mucosa of the rat by MacDonald WC, Dueck JW. (PubMed)
(18) Legume, soy, tofu, and isoflavone intake and endometrial cancer risk in postmenopausal women in the multiethnic cohort study by Ollberding NJ1, Lim U, Wilkens LR, Setiawan VW, Shvetsov YB, Henderson BE, Kolonel LN, Goodman MT. (PubMed)
(19) Soy food and isoflavone intake and endometrial cancer risk: the Japan Public Health Center-based prospective study by Budhathoki S1, Iwasaki M, Sawada N, Yamaji T, Shimazu T, Sasazuki S, Inoue M, Tsugane S; JPHC Study Group(PubMed)
(20) Association of soy and fiber consumption with the risk of endometrial cancer by Goodman MT1, Wilkens LR, Hankin JH, Lyu LC, Wu AH, Kolonel LN. (PubMed)
(21) Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women by Hosono S1, Matsuo K, Kajiyama H, Hirose K, Suzuki T, Kawase T, Kidokoro K, Nakanishi T, Hamajima N, Kikkawa F, Tajima K, Tanaka H.(PubMed)
(22) Lack of effect of soy isoflavone on thyroid hyperplasia in rats receiving an iodine-deficient diet by Son HY1, Nishikawa A, Ikeda T, Imazawa T, Kimura S, Hirose M.(PubMed)
(23) Dramatic synergism between excess soybean intake and iodine deficiency on the development of rat thyroid hyperplasia by Ikeda T1, Nishikawa A, Imazawa T, Kimura S, Hirose M.(PubMed)

The #Soyfood Effects on #VasomotorSymptoms in Japanese, According to Studies

Kyle J. Norton

Soybean, the genus Glycine, belonging to the family Fabaceae, is one of the legumes that contains twice as much protein per acre than any other major vegetable or grain crop, native to Southeast Asia. Now, it is grown worldwide with a suitable climate for commercial profits.

Japan, an island nation in the Pacific Ocean, lies to the east of the Sea of Japan, China, North Korea, South Korea, and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south(1c). According to Moriyama, Japanese women and men live longer and healthier than everyone else on Earth, it may be a result of a healthier Japanese diet and lifestyle. According to the World Health Organization, the Japanese have an average of 75 years of healthy living disability-free, it may be due to the average soy intake being 10 to 70 times higher than in Western people(1a)(1b).

Menopause is defined as a condition in which women have not had a menstrual period in a minimum of 12 months period as a result of the inactive ovaries, assuming the women are not pregnant and experience the ease of visible symptoms of menopause such as hot flashes and night sweats but not the invisible effects of menopause. During postmenopause, any bleeding or spotting should be reported to your doctor immediately, because it may be caused by tumors rarely but it is possible. Symptoms may include Bleeding or spotting, Vagina itching and dryness, Hot flash, Bone pain, and fracture, Bladder infection, Skin wrinkle, Hypertension, Bone density loss, etc.

Epidemiological studies, linking soy effects on menopause symptoms have been inconclusive(1)(2)(3)(4). In Japanese women, phytochemicals in soy were found effectively in reducing vasomotor symptoms of menopause. In the study of a supplement containing equol on menopausal symptoms in Japanese, researchers at the Tokyo Medical and Dental University showed that the equol-ingesting group, not only significantly reduces the severity and frequency of hot flashes, neck or shoulder but also exhibited trends of improvement in sweating and irritability and a significant improvement in the somatic category symptoms(5). Administration of a 10-mg natural S-(-)equol supplement consumed daily for 12 weeks also indicated a reduction of hot flushes and neck or shoulder muscle stiffness, in postmenopausal Japanese women(6). And fermented soy products have been also showed to alleviate the severity of hot flushes(14).

Some researchers suggested that the effectiveness of soy isoflavone in relieving symptoms of menopause may link to equol-producing status. In a 1-year double-blind, randomized trial in comparison of the effects of isoflavone (75 mg of isoflavone conjugates/day) in early postmenopausal equol-producer phenotype Japanese women, found that isoflavones exhibit preventive effects on bone loss and fat accumulation in early postmenopausal women, depending on an individual's equol-producing capacity(7) and S-equol supplement improved mood-related symptoms in perimenopausal/postmenopausal even in equol nonproducers in Japan women, in a total of 127 participants completed the trial(8).

Soy isoflavone extracts on testing on the lumbar spine or hip BMD in menopausal women of controlled trials published in English, Japanese, or Chinese, showed a result of varying effects on spine BMD(9). In comparing the symptom of hot flashes and chilliness in menopausal women, Dr. Melby MK. suggested that Japanese women experience more important vasomotor symptoms than hot flushes and sweats, it may be a result of a dietary high in soy(10).

In Osteoporosis, menaquinone-7, the major chemical compound found in Japanese fermented soybeans, showed to prevent postmenopausal bone loss(11) and promote bone formation(13)(15) as well alleviating early postmenopausal women symptoms, such as in palpitation and backaches(15). Another study also suggested that the intake of supplementation of isoflavones (ISO) is regular associates to risk reduction of osteoporosis in middle-aged Japanese and menopausal Japanese women(12).

In fact, according to the study of cross-sectional relationships between dietary and other lifestyle variables to menopause by the Gifu University School of Medicine, such smoking, calcium, and soy product intakes, intakes of fat, cholesterol, and coffee were significantly associated with the onset menopause in Japanese women(16).

Taken altogether, High soy food intakes are associated to reduce symptoms of menopause in Japanese women, especially in the major menopausal symptom of chilliness. Intake of a supplement containing equol is effective in symptom reduction even in nonequol producers in these populations as well. According to the Royal Hospital for Women, the highest soy consumption in Japan lowered the rates of diseases, including breast, endometrial, colon, and prostatic cancers atherosclerotic, etc. The induced extremely high urinary levels of phytoestrogen metabolites may be a result of isoflavones in exhibited bioactivity when intake of high concentrations. (17)

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(a) The Science of Soy: What Do We Really Know? by Julia R. Barrett
(b) Guideline for healthy soy intake(the Unite Soybean board)
(1c) Japan, Wikipedia
(1a) Erdman JW Jr. AHA Science Advisory: soy protein and cardiovascular disease: a statement for healthcare professionals from the Nutrition Committee of the AHA. Circulation. 2000; 102: 2555–2559
(Soy protein and cardiovascular disease)
(1b) van der Schouw YT, Kreijkamp-Kaspers S, Peeters PH, Keinan-Boker L, Rimm EB, Grobbee DE. Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in Western women. Circulation. 2005; 111: 465–471(Cardiovascular diseases in women)
(1) S-equol and the fermented soy product SE5-OH containing S-equol similarly decrease ovariectomy-induced increase in rat tail skin temperature in an animal model of hot flushes by Yoneda T1, Ueno T, Uchiyama S.(PubMed)
(2) A pilot study on the effects of S-equol compared to soy isoflavones on menopausal hot flash frequency by Jenks BH1, Iwashita S, Nakagawa Y, Ragland K, Lee J, Carson WH, Ueno T, Uchiyama S.(PubMed)
(3) Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis of randomized controlled trials by Taku K1, Melby MK, Kronenberg F, Kurzer MS, Messina M.(PubMed)
(4) Treatment of vasomotor symptoms of menopause with black cohosh, multibotanicals, soy, hormone therapy, or placebo: a randomized trial by Newton KM1, Reed SD, LaCroix AZ, Grothaus LC, Ehrlich K, Guiltinan J.(PubMed)
(5) Equol improves menopausal symptoms in Japanese women by Aso T.(PubMed)
(6) A natural S-equol supplement alleviates hot flushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women by Aso T1, Uchiyama S, Matsumura Y, Taguchi M, Nozaki M, Takamatsu K, Ishizuka B, Kubota T, Mizunuma H, Ohta H.(PubMed)
(7) Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women: a double-blind, randomized, controlled trial by Wu J1, Oka J, Ezaki J, Ohtomo T, Ueno T, Uchiyama S, Toda T, Uehara M, Ishimi Y.(PubMed)
(8) New equol supplement for relieving menopausal symptoms: randomized, placebo-controlled trial of Japanese women by Ishiwata N1, Melby MK, Mizuno S, Watanabe S.(PubMed)
(9) Effect of soy isoflavone extract supplements on bone mineral density in menopausal women: meta-analysis of randomized controlled trials by Taku K1, Melby MK, Takebayashi J, Mizuno S, Ishimi Y, Omori T, Watanabe S.(PubMed)
(10) Chilliness: a vasomotor symptom in Japan by Melby MK. (PubMed)
(11) Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study by Ikeda Y1, Iki M, Morita A, Kajita E, Kagamimori S, Kagawa Y, Yoneshima H.(PubMed)
(12) Soy isoflavone tablets reduce osteoporosis risk factors and obesity in middle-aged Japanese women by Mori M1, Aizawa T, Tokoro M, Miki T, Yamori Y.(PubMed)
(13) Promotion of bone formation by fermented soybean (Natto) intake in premenopausal women by Katsuyama H1, Ideguchi S, Fukunaga M, Fukunaga T, Saijoh K, Sunami S.(PubMed)
(14) Hot flushes and other menopausal symptoms in relation to soy product intake in Japanese women by Nagata C1, Shimizu H, Takami R, Hayashi M, Takeda N, Yasuda K.(PubMed)
(15) Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women by Somekawa Y1, Chiguchi M, Ishibashi T, Aso T.(PubMed)
(16) Association of diet and other lifestyle with onset of menopause in Japanese women by Nagata C1, Takatsuka N, Inaba S, Kawakami N, Shimizu H.(PubMed)
(17) Phytoestrogens and the menopause by Mackey R1, Eden J.(PubMed)

#Herbal #Turmeric Reduces the Serum Levels of Transforming Growth Factor Associated with Kidney Dysfunction & Type 2 Diabetic Nephropathy , Researchers Say

Kyle J. Norton

Diabetic nephropathy (diabetic kidney disease) is a complication of kidney damage caused by diabetes.
Long-term unmanaged hyperglycemia can damage the part of the kidneys thus reducing the kidney function in filtering waste from the blood filters, leading to 'leaky' syndrome that allows protein into your urine.

Diabetic nephropathy is the 3 stage of kidney change in patients with diabetes. In this stage, patients may experience symptoms of abnormally elevated urinary albumin excretion, compared to the 15 and 300 μg/min in the baseline situation.

The progression of diabetic nephropathy that leads to an increased rate of albumin excretion is higher in patients with increased blood pressure.

More importantly, if high blood pressure is left untreated, diabetic nephropathy can induce persistent proteinuria >0.5 g/ 24 h that furtherly declines the renal function with the mean fall rate being around 1 ml/min/mo.

In other words, by treating hypertension and hyperglycemia in patients with diabetes, the progression of diabetic kidney disease may be slowed or preventable.

Some researchers suggested that
* By maintaining healthy blood glucose levels and keeping them within the target range.

* By a change of healthful diet.

* By getting moderate and regular exercise

* By maintaining a healthy weight

* Particularly, by following a treatment plan, including the use of insulin or other medications.

The most common symptoms of diabetic nephropathy are worsening blood pressure control, protein in the urine, swelling of feet, ankles, hands, or eyes, frequent urination, confusion, or difficulty concentrating.

If you are diabetes associated with the aforementioned symptoms, please check with your doctor to rule out the possibility.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potential and natural source for the treatment of diabetic complications, researchers examined the effects of the bioactive compound curcumin anti-diabetic nephropathy (DN), the most common cause of end-stage renal disease in most parts of the world.

40 patients in the Diabetes Clinic of the Outpatient Department of Shiraz University of Medical Sciences with overt type 2 diabetic nephropathy were randomized into a trial group (n = 20) and a control group (n = 20).

The treatment group received one capsule with each meal containing 500 mg turmeric, of which 22.1 mg was the active ingredient curcumin (three capsules daily) compared to the control group received three capsules identical in color and size containing starch for the period of 2 months.

Compared to the control group. patients treated with turmeric showed significantly reduced serum levels of transforming growth factor-β (TGF-β) and IL-8 associated with the production of pro-inflammatory cytokine and urinary protein excretion, the indications of kidney dysfunction.

The same results were also found in the comparison of the pre-and post-turmeric supplementation values.

Furthermore, there is no side effect reported in patients of the treatment group.

In other words, turmeric containing curcumin used in the experiment protects the kidney cells against the onset of diabetic nephropathy without inducing any adverse effects.

Dr. Khajehdehi P, the lead scientist based on the finding wrote, "Short-term turmeric supplementation can attenuate proteinuria, TGF-β, and IL-8 in patients with overt type 2 diabetic nephropathy and can be administered as safe adjuvant therapy for these patients".

Taken altogether, turmeric-processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of diabetic nephropathy, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of curcumin in experimental diabetic nephropathy by Prabhakar SS. (PubMed)
(2) Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study by Khajehdehi P1, Pakfetrat M, Javidnia K, Azad F, Malekmakan L, Nasab MH, Dehghanzadeh G. (PubMed)
(3) The Stages in Diabetic Renal Disease: With Emphasis on the Stage of Incipient Diabetic Nephropathy by C E Mogensen, C K Christensen and E Vittinghus(The Diabetes Association)

#Bilberry Extract and #Anthocyanins Found in Bilberry Inhibit the Risk of Cancer, According to Studies

Kyle J. Norton

Cancer is a group of cell-mutated diseases caused by the alternation of DNA.
Most cases of cancer begin in the cells on the surface of the inner lining of the tissue of an organ. At the early, most people with cancer are asymptomatic, however, later, due to the size and the tumor, patients may experience general cancer symptoms such as unintended weight loss, fatigue, gastrointestinal discomfort, loss of appetite, and localized symptoms such as severe pain and bleeding.

The exact causes of cancer are not identified. As of today, researchers do not know why one person develops cancer and another doesn’t, even though they share some common risk factors for the disease.

However, the most prevalent factors associated with the cancer onset include age, family history, long-term exposure to certain cancer-induced chemicals, use of tobacco, and excessive alcohol drinking,..... the list goes on and on, depending on the type of cancer.

Some researchers suggested that the most common risk factor that causes cancer in the Western world may be associated with widespread obesity.

Dr. Karen Basen-Engquist, in the evaluation of the obesity risk of cancer, said, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%".

And, "High priorities for future research involve additional work on the underlying mechanisms, and trials to examine the effect of lifestyle behavior change and weight loss interventions on cancer and intermediate biomarkers".

The findings strongly indicated the risk of cancer is increased substantially in obese.

Bilberry is a species of low-growing shrub in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.


The plant has been used as  herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

Searching the list of natural compounds with a strong potential for the treatment of cancer with no side effects, scientists investigated the secondary metabolites including flavonoids (1-8), caffeic (9), and chlorogenic (10) acids from the extract of Sakhalin bilberry Vaccinium small leaves in vitro.

All 10 metabolites included in the study displayed a significant effect in the inhibition of EGF-induced neoplastic transformation in the conversion of normal cells into tumor cells of mouse JB6 Cl 41 P+ cells.

Furthermore, none of the compounds isolated from bilberry extract showed non-toxic against JB6 Cl 41 P+ cells up to a concentration of 200 µm.

The results suggested that bilberry secondary metabolites protect the normal against the alternation of cell's DNA without causing harm to the nearby healthy normal cells.

In HL60 cells, injection of bilberry extract induced apoptotic cell bodies and nucleosomal DNA fragmentation.

However, bilberry did not exert similar effects against the HCT116. The proportion of apoptotic cells induced in HCT116 was much lower than that in HL60 cells, without the presence of DNA fragmentation.

According to the extracted analysis, the efficacy of bilberry against cancer cell lines was attributed to the bioactive phenolic compounds, including anthocyanins in initiating the free radical scavenging property.

Dr. Katsube N, the lead scientist after taking into account co and confounders wrote in the final report, "These results indicate that the bilberry extract and the anthocyanins, bearing delphinidin or malvidin as the aglycon, inhibit the growth of HL60 cells through the induction of apoptosis".


Taken altogether, bilberry processed significant bioactive secondary metabolites may be considered a functional remedy for the prevention and treatment of cancer, pending the validation of a larger sample size and multicenter human study.

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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Cancer-preventive activities of secondary metabolites from leaves of the bilberryVaccinium small A. Gray by Mechikova GY1, Kuzmich AS, Ponomarenko LP, Kalinovsky AI, Stepanova TA, Fedorov SN, Stonik VA. (PubMed)
(2) Induction of apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyanins by Katsube N1, Iwashita K, Tsushida T, Yamaki K, Kobori M. (PubMed)
(3) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist and Maria Chang. (PMC)

#Healthyfood #Onion Exhibits a Significant Effect in Reducing the Risk of #ProstateCancer, According to Studies

Kyle J. Norton

The prostate warped around a tube (the urethra) is a gland of the male reproductive system found in front of the rectum and just below the bladder and responsible for making some of the semen that carries sperm.

The prostate gland is considered a reproductive organ in men.

Prostate cancer is a medical condition caused by cell growth disorderly in the prostate tissue due to the alternation of DNA.

At the advanced stage, the cancerous cell in the prostate can spread to a distance away to inject other healthy tissue and organ, leading to secondary metastasis through lymph and blood.


Most prostate cancers are slow-growing and enlarged prostate and prostate cancer may be detected during physical (rectum) exams.

According to the statistics provided by the American Cancer Society, approximately 174,650 cases of prostate cancer will be diagnosed in 2019. Prostate cancer will cause the death of 31620 Americans.

The exact causes of prostate cancer are not known. However, epidemiologically, below are some of the most prevalent factors associated with prostate cancer risk

*Age
The risk of developing prostate cancer increases with the age of over 45

* Family history
Statistics showed that if one of your directed family members has prostate cancer, you are twice at risk to develop it as well.

*Race
Prostate cancer is more likely to strike black and white or Hispanic men in the US.

* Heredity
Certain genes mutation is associated in promoting the growth of prostate cancer, including hereditary prostate cancer gene 1 (HPC1), transmembrane protease, serine 2-ERG or transmembrane protease, serine 2-ETV1/4, etc.

Researchers found that up to 70 percent of men with prostate cancer have lost one copy of the Phosphatase and tensin homolog (PTEN) gene at the time of diagnosis. The tumor protein 53
(p53) mutations are a late event in the pathology of prostate cancer.

* Low levels of vitamin D in the blood
Researchers found that men with a deficiency of level of vitamin D in the blood are at higher risk to develop prostate cancer.

* Excessive drinking
Excessive drinking not only increases the risk of liver cancer but is also associated with a higher risk of prostate cancer as it interferes with folate metabolism. The risk of prostate cancer is much high for men with excessive drinking habits and folate deficiency.

* Enlarged prostate
Men with an enlarged prostate are at high risk of developing prostate cancer.

* Sexual transmission diseases
Infected diseases such as chlamydia, gonorrhea, or syphilis are associated with a higher risk of the diseases.

*Obesity
In a study of Obesity May Raise Risk of Prostate Cancer Spread, Christopher J. Keto, MD, a urological oncology postdoctoral associate at Duke University Medical Center, Durham, N.C. found that overweight men were three times more likely to have their cancer spread.

The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.

With an aim to find a potential compound for the promotion of prostate health, researchers examined the effect of onion on prostate cancer in vivo and in vitro.

According to a population-based case-control study in Shanghai, Hsing et. al. participants in the highest of 3 intake categories of total Allium vegetables, including onion showed a significant effect in reducing the risk of prostate cancer with the relative odds ratio risk of .53 compared to those with the lowest intake.

In the Italian and Swiss case-control networks study, researchers surprisingly showed that participants with the highest intake of both onions do not have significantly decreased OR of prostate cancer compared to those with the lowest intake, However, according to the differentiation, there was evidence of a trend of decreased odds with increasing intake.
In other words, over time, increased intake of onion may have significant activity in reducing prostate cancer risk.

The results strongly suggested, over time, regular consumption may decrease the risk of prostate cancer, depending on the amount of onion intake daily.

Taken altogether, onion used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of adjuvant rheumatic diseases, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Prostate Cancer by Kyle J. Norton

#Yoga Improves the Control, Relaxed, Positive Instinctive or Intuitive Feeling in Patients with #BehavioralAddiction

Kyle J. Norton

Epidemiological studies strongly suggested that yoga as an integrated form of exercise may be used for the treatment of behavioral addiction.

Yoga, the ancient practical technique for harmonizing external and internal body well beings, through breath control, meditation, bodily movement, and gesture..... has been best known to people in the Western world and some parts of Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.

According to the joint study led by the University of Florida, yoga may be considered as an adjunct treatment in behavioral addiction through inducing "dopamine homeostasis", or in simpler terms "normalcy".

Prevention of addictive diseases is a complex and systematic strategy including training of social skills, decision in-making skills, family intervention, etc. particularly, in making the treatment more effective.

Combination of physical exercise and yoga may be useful components of comprehensive programs, especially in the treatment of patients in substance-dependent patients and pathological gamblers.

Yoga and other forms of treatment may regulate the resting-state functional connectivity (rsfMRI), a method of functional brain imaging, used to evaluate regional interactions and restore this impaired cross-talk between various brain regions (e.g. Nucleus accumbens, cingulate gyrus, hippocampus, etc.)

Truly, physical exercise, a planned, organized, and repeated body movement and yoga practice not only promoted physical fitness but also alleviated the stress and anxiety in the induction of impulsive behavior, thus relieving craving behavior, suppressing abstinence symptoms, through ameliorating hormone production in response to stress and activated impulsive behavior, such as hormone cortisol, dopamine, ghrelin,...

Moreover, the intensities of exercise study showed a two- to three-fold longer time to the next cigarette, reduced substantially cravings withdrawal symptoms, and decreased heart rate reserve (HRR) (lasting 30-40 minutes) from 60-85% to as low as 24% HRR (lasting 15 minutes).

Dr. Taylor AH, the lead author of the study "The acute effects of exercise on cigarette cravings, withdrawal symptoms, affect and smoking behavior: a systematic review", said, "withdrawal symptoms and negative affect decreased rapidly during exercise and remained reduced for up to 50 minutes after exercise. Effect sizes for seven studies that assessed "strength of desire to smoke" showed a mean reduction, 10 minutes after exercise, of 1.1".

Some researchers also suggested that yoga intervention, directly and indirectly, drive the attention and energy to the root of suffering by restoring the balances of the mind and body, bringing back the presence and dealing how to control impulsive behaviors in a positive way through breathing and body control.

Indeed, compared to yoga intervention, competitive professional sports instead increased the number of risk factors for substance-related problems.


More interestingly, the study of 17 clients from the Problem Gambling Institute of Ontario at the Centre for Addiction and Mental Health (88% male) to evaluate the feasibility of teaching problem gamblers about mindfulness meditation as part of regular treatment for problem gambling by 8-week mindfulness group program, researchers found that in the comparison of the first group session and after the final group session, yoga mindfulness increase the Mindfulness Attention Awareness Scale (MAAS) scores from a pre-test score of 3.65 (SD = 1.01) to a post-test score of 4.40 (SD = 0.78) and

Participants also highlighted a number of improvements in being more in control, relaxed, and able to stay in the now.

In fact, yoga mindfulness participated demonstrated a high level of positive instinctive or intuitive feeling with the improvement of the ability to control emotion and acted, according to the values while experiencing negative emotions, by adapting to the change of environment.

Additionally, yoga attendees also expressed gaining management skills in controlled poor emotion regulation which may lead to impulsive behavior.

Participants with difficulty in the appropriate management of emotions were found to associate with a variety of psychiatric illnesses, including depression and anxiety


Further analysis of yoga mindfulness effectiveness, researchers opinionated, "the suitability of mindfulness as an intervention as part of a problem gambling treatment service. However, the study did not evaluate whether mindfulness improved the clients’ ability to resist relapse".

Taking it all together, yoga may be considered a secondary and integrated form of treatment combined with standard therapy in treating behavioral addiction.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Addiction Treatment in America: After Money or Aftercare? by Miller D1, Miller M1, Blum K2, Badgaiyan RD3, Febo M4.(PubMed)
(2) [Physical exercise and yoga in preventing and treating addictive diseases].[Article in Czech] by Nespor K1.(PubMed)
(3) Mindfulness and problem gambling treatment by Peter Chen, Farah Jindani, Jason Perry, Nigel L Turner(Springer link)
(4) Mindfulness-Based Approaches to Impulsive Behaviors Kelcey J. Stratton, M.A.(The New School Psychology BulletinVolume 4, No. 2, 2006)
(5) The acute effects of exercise on cigarette cravings, withdrawal symptoms, affect and smoking behavior: a systematic review by Taylor AH1, Ussher MH, Faulkner G.(PubMed)

#Cholagogum (Dried Extracts from Schöllkraut and Curcuma) Ameliorates Symptoms of Biliary Dyskinesia, According to Clinical Trials

Kyle J. Norton

Biliary dyskinesia is a medical disorder associated with the gallbladder and sphincter, affecting the biliary system to facilitate the normal flow of bile.

Some researchers suggested that the condition is a symptom of bladder disease such as cholecystitis, gallstone, or pancreatitis, rather than being a disease itself.

The most common symptom is pain in the right upper quadrant where the gallbladder is located.

However, some patients may also experience the symptom of pain that does not stop with medication, including pain the under the ribs and in the back right shoulder blade.

Other patients may also experience symptoms of nausea and vomiting, indigestion, bloating, and belching.

If you have experienced persistent pain above that can be relieved by medication, please check with your doctor to rule out the possibility.

The cause of biliary dyskinesia is unknown. However, researchers do know that people who are of older age, obesity groups, and female gender are at a higher risk of the condition.

Believe it or not, women who are or who have been pregnant, taking birth control pills or in their menopausal years are at substantial risk of biliary dyskinesia developing compared to others.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In finding a potential compound for the treatment of biliary dyskinesia, researchers investigated the turmeric effect on the right upper abdominal pain in biliary dyskinesia patients.

74 patients with the condition were selected for the trial and randomly assigned to either received Cholagogum (dried extracts from Schöllkraut and Curcuma) (39 patients) or placebo (37 patients) for 3 weeks.

According to the tested assays, dumpy and colicky pain was more rapid during the first treatment week in the Cholagogum F group compared to the placebo.

However, both groups exerted similar effects in reducing the feeling of being filled up, food intolerance, nausea, vomiting, and meteorism, during the whole treatment period.

There are no side effects in the treatment group.

In other words, dried extracts from Schöllkraut and Curcuma inhibited the symptoms of biliary dyskinesia, without inducing any side effects.

Dr. Niederau C the lead scientist after taking into account co and confounders said, "The study presents the first solid indication that extracts from Schöllkraut/Curcuma (Cholagogum F Nattermann) which have widely been used in daily practice for many decades have beneficial effects on pain due to biliary dyskinesia".

Taken altogether, turmeric used alone or combined with another remedy may be considered a supplement for treating the symptoms of biliary dyskinesia, pending confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [The effect of Chelidonium- and turmeric root extract on upper abdominal pain due to functional disorders of the biliary system. Results from a placebo-controlled double-blind study].[Article in German] by Niederau C1, Göpfert E. (PubMed)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)