By Kyle J. Norton
Bladder cancer is a medical condition characterized by irregular cell growth in the tissues of the bladder. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.
According to statistics provided by cancer.net, 90% of people with bladder cancer are older than 55, and the average age of people diagnosed with bladder cancer is 73
In the review of medical literature published online, green tea major catechin EGCG in reduced risk and treatment may be attributed to a number of mechanisms.
In T24 human bladder cancer cell line, the application of the chemopreventive/antiproliferative potential of (-)-epigallocatechin gallate (EGCG, the major phytochemical in green tea) induced anti-malignant cell proliferation by modulating the expression of phosphatidylinositol 3' kinase/Akt in the activating Bcl-2 family proteins with a function in the regulation of cell death, thus enhancing apoptosis of T24 bladder cancer cell line in a dose- and time-dependent manner.
The phosphatidylinositol 3'-kinase/AKT pathway is a crucial regulator of cellular processes including cell proliferation and apoptosis.
Bcl-2 family proteins is a modulator responsible for the regulation of cell apoptosis.
In C3H/HeN mice subcutaneously implanted with MBT-2 murine bladder tumor cells, administration of EGCGs physically attached to the surface of nanogold particles pNG(EGCG-adsorbed pNG) exerted a significant anti-cancer proliferation through induction of apoptosis.
This action of anti-cancer effect was attributed to a mechanism of EGCG-pNG in the activation of caspases which plays an important role in induced cell apoptosis and inflammation through Bcl-family proteins with a function in control apoptosis by activating caspase proteases in governing the space between outer and inner mitochondrial membrane.
Under stress, the mitochondrial pathway or the intrinsic pathway is activated depending on the release of proteins from the intermembrane space of mitochondria.
Caspase cascade, family protease enzymes with function in programmed cell death and inflammation.
Additionally, injecting EGCG-pNG directly into the tumor site inhibited tumor expansion through ameliorated the function of vascular endothelial growth factor (VEGF) in the stimulated formation of a new blood vessel in provided nutrients and oxygen for the survival of the cancer site compared to
oral administration of EGCG in stimulated immune function in suppression of cancer progression.
The vascular endothelial growth factor is a signal protein produced by cells in the stimulated formation of the blood vessel for cell division and site proliferation.
Based on the information, the prepared EGCG-pNG was more effective than free EGCG in inhibiting bladder tumors in model mice.
More interestingly, bladder tumor induced by N-butyl-(-4-hydroxy butyl) nitrosamine (BBN) 0.05% solution on 8-week-old female C3H/He mice for 14 or 24 weeks on treatment with or without green tea polyphenols (GTP) expressed a significantly lower rate of tumor invasive frequency of 23.8%; in the group treated with both GTP and BBN in compared to 65.2% in the group treated with BBN alone.
The tumor volume and microvascular density (MVD) as an independent predictor within a tumor and the connective, functionally supportive framework of a biological cell, tissue, or organ region in the BBN+GTP group were also significantly lower than in BBN-treated mice.
Unbelievably, green tea polyphenols inhibited tumor growth and invasion in mice with established bladder cancer through regulation of angiogenetic effect on suppressing the forming of the new blood vessel for tumor cells proliferation, metastatic spread, as well as providing oxygen and nutrients and removal of waste products of cancer cells without exhibiting the anti-carcinogenic effect.
Taken together, green tea extract polyphenols may be considered an adjunct therapy for reduced risk and used a combination with standard medicine for the treatment of bladder cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) A component of green tea, (-)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins by Qin J1, Xie LP, Zheng XY, Wang YB, Bai Y, Shen HF, Li LC, Dahiya R.(PubMed)
(2) The treatment of bladder cancer in a mouse model by epigallocatechin-3-gallate-gold nanoparticles by Hsieh DS1, Wang H, Tan SW, Huang YH, Tsai CY, Yeh MK, Wu CJ.(PubMed)
(3) Green tea polyphenol suppresses tumor invasion and angiogenesis in N-butyl-(-4-hydroxybutyl) nitrosamine-induced bladder cancer by Sagara Y1, Miyata Y, Nomata K, Hayashi T, Kanetake H.(PubMed)
Friday, 16 June 2023
#CucurbitacinB Found in Cucumber Combined with Docetaxel Inhibit #LaryngealCancer Through Cell Cycle Arrest in Vitros
By Kyle J. Norton
Laryngeal cancer is a medical condition characterized by abnormal cell growth in the tissues of the larynx due to the alternation of cells' DNA.
Larynx, also known as the voice box is a tube above the windpipe (trachea) in the neck and in front of the food pipe.
Most cases of laryngeal cancer start in the cell on the surface of the inner lining of the larynx, before penetrating into the deeper layers to form a tumor.
At the very early of cell alternation, patients are asymptomatic. However, as the tumor continues to grow, the cancer cell may infect other healthy tissues a distance away through the blood and fluids distribution.
Laryngeal cancer shares the general symptoms with other cancer including unintended pain, weight loss, loss of appetite, fatigue, and gastrointestinal discomforts accompanied by specific symptoms of a lump or swelling in your neck. a long-lasting cough, a persistent sore throat or earache, and difficulty breathing. in severe cases.
Sometimes, patients may vomit blood due to the oversize tumor which has pressed on the nearby blood vessels.
Out of many prevalent risk factors, smoking tobacco (cigarettes, pipes, cigars) is considered a major culprit that increases the risk of developing laryngeal cancer in the Western world.
Dr. A Altieri, the lead scientist wrote, "Cancer of the larynx is extremely rare in individuals who neither smoke nor drink alcohol (Austin and Reynolds, 1996). The risk rises with increasing levels of smoking and drinking, each agent approximately multiplying the effects of the other (Elwood et al, 1984; Blot, 1992; Dosemeci et al, 1997; Talamini et al, 2002). The risk of laryngeal cancer is 10–20-fold higher in current smokers than in non-smokers".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find potential and natural chemotherapy for the treatment of laryngeal cancer, researchers examined whether cucurbitacin B can also enhance the sensitivity of Hep-2 laryngeal cells to cisplatin.
The study included the evaluation of the proliferation, cell cycle distribution, and apoptosis in Hep-2 cells treated with either cucurbitacin B, cisplatin, or a combination.
According to the tested results, Hep-2 cells treated with a cucurbitacin B/cisplatin combination display synergistic effects on growth inhibition, cell cycle arrest, and apoptosis induction, compared to single-agent cucurbitacin B or cisplatin-treated cells.
Moreover, Hep-2 cell lines treated with the cucurbitacin B/cisplatin combination demonstrated a significantly reduced level of p-Stat3, compared to single-agent treated cells.
Where overexpression of p-STAT3 is an indication of a poor prognosis biomarker in cancer.
Additionally, cucurbitacin B/cisplatin-treated Hep-2 cells also demonstrated a significant reduction of the protein associated with regulation in the cell cycle and anti-apoptosis, compared to single-agent cucurbitacin B or cisplatin-treated cells.
Based on the results, researchers said, "These results suggest that the cucurbitacin B/cisplatin combination treatment may be a potentially useful therapeutic option for individuals diagnosed with laryngeal cancer".
In order to reveal more information about cucumber's anti-laryngeal cancer properties, scientists evaluated the combined antitumor effect of cucurbitacin B with docetaxel on Hep-2, a human laryngeal cancer cell line.
The combination of cucurbitacin B and docetaxel produced greater efficacy in growth inhibition, cell cycle arrest at the G2/M phase, and apoptosis induction similar to those of the aforementioned study compared to single agent treatment.
The efficacy of the combined effect of cucurbitacin B and docetaxel anti-Hep-2 was attributed to the suppression of the expression of proteins involved in tumor proliferation and migration.
In vivo, the combination of cucurbitacin B with docetaxel also synergestively inhibited tumor growth in a mouse xenograft model.
Taken altogether, cucumber processed with a high amount of cucurbitacin B may be considered supplements combined with conventional medicine for the treatment of laryngeal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of cucurbitacin B in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin by Liu T1, Peng H, Zhang M, Deng Y, Wu Z. (PubMed)
(2) Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer by Liu T1, Zhang M, Zhang H, Sun C, Yang X, Deng Y, Ji W. (PubMed)
(3) Cessation of smoking and drinking and the risk of laryngeal cancer by A Altieri,1 C Bosetti,1 R Talamini,2 S Gallus,1 S Franceschi,3 F Levi,4 L Dal Maso,2 E Negri,1and C La Vecchia. (PMC)
Laryngeal cancer is a medical condition characterized by abnormal cell growth in the tissues of the larynx due to the alternation of cells' DNA.
Larynx, also known as the voice box is a tube above the windpipe (trachea) in the neck and in front of the food pipe.
Most cases of laryngeal cancer start in the cell on the surface of the inner lining of the larynx, before penetrating into the deeper layers to form a tumor.
At the very early of cell alternation, patients are asymptomatic. However, as the tumor continues to grow, the cancer cell may infect other healthy tissues a distance away through the blood and fluids distribution.
Laryngeal cancer shares the general symptoms with other cancer including unintended pain, weight loss, loss of appetite, fatigue, and gastrointestinal discomforts accompanied by specific symptoms of a lump or swelling in your neck. a long-lasting cough, a persistent sore throat or earache, and difficulty breathing. in severe cases.
Sometimes, patients may vomit blood due to the oversize tumor which has pressed on the nearby blood vessels.
Out of many prevalent risk factors, smoking tobacco (cigarettes, pipes, cigars) is considered a major culprit that increases the risk of developing laryngeal cancer in the Western world.
Dr. A Altieri, the lead scientist wrote, "Cancer of the larynx is extremely rare in individuals who neither smoke nor drink alcohol (Austin and Reynolds, 1996). The risk rises with increasing levels of smoking and drinking, each agent approximately multiplying the effects of the other (Elwood et al, 1984; Blot, 1992; Dosemeci et al, 1997; Talamini et al, 2002). The risk of laryngeal cancer is 10–20-fold higher in current smokers than in non-smokers".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find potential and natural chemotherapy for the treatment of laryngeal cancer, researchers examined whether cucurbitacin B can also enhance the sensitivity of Hep-2 laryngeal cells to cisplatin.
The study included the evaluation of the proliferation, cell cycle distribution, and apoptosis in Hep-2 cells treated with either cucurbitacin B, cisplatin, or a combination.
According to the tested results, Hep-2 cells treated with a cucurbitacin B/cisplatin combination display synergistic effects on growth inhibition, cell cycle arrest, and apoptosis induction, compared to single-agent cucurbitacin B or cisplatin-treated cells.
Moreover, Hep-2 cell lines treated with the cucurbitacin B/cisplatin combination demonstrated a significantly reduced level of p-Stat3, compared to single-agent treated cells.
Where overexpression of p-STAT3 is an indication of a poor prognosis biomarker in cancer.
Additionally, cucurbitacin B/cisplatin-treated Hep-2 cells also demonstrated a significant reduction of the protein associated with regulation in the cell cycle and anti-apoptosis, compared to single-agent cucurbitacin B or cisplatin-treated cells.
Based on the results, researchers said, "These results suggest that the cucurbitacin B/cisplatin combination treatment may be a potentially useful therapeutic option for individuals diagnosed with laryngeal cancer".
In order to reveal more information about cucumber's anti-laryngeal cancer properties, scientists evaluated the combined antitumor effect of cucurbitacin B with docetaxel on Hep-2, a human laryngeal cancer cell line.
The combination of cucurbitacin B and docetaxel produced greater efficacy in growth inhibition, cell cycle arrest at the G2/M phase, and apoptosis induction similar to those of the aforementioned study compared to single agent treatment.
The efficacy of the combined effect of cucurbitacin B and docetaxel anti-Hep-2 was attributed to the suppression of the expression of proteins involved in tumor proliferation and migration.
In vivo, the combination of cucurbitacin B with docetaxel also synergestively inhibited tumor growth in a mouse xenograft model.
Taken altogether, cucumber processed with a high amount of cucurbitacin B may be considered supplements combined with conventional medicine for the treatment of laryngeal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of cucurbitacin B in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin by Liu T1, Peng H, Zhang M, Deng Y, Wu Z. (PubMed)
(2) Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer by Liu T1, Zhang M, Zhang H, Sun C, Yang X, Deng Y, Ji W. (PubMed)
(3) Cessation of smoking and drinking and the risk of laryngeal cancer by A Altieri,1 C Bosetti,1 R Talamini,2 S Gallus,1 S Franceschi,3 F Levi,4 L Dal Maso,2 E Negri,1and C La Vecchia. (PMC)
#Greentea's #EGCG)Inhibits #EsophagealCancer through Cell Cycle Arrest and Apoptosis in Vitros
By Kyle J. Norton
Esophageal cancer is a medical condition characterized by irregular cell growth in the tissues of the esophagus. At the later stage, the cancerous cells may travel a distance away to invade other healthy tissues and organs. According to statistics, 2,300 Canadians will be diagnosed with esophageal cancer in 2017.
In the review of the literature published online, green tea efficacy in the treatment of human esophageal squamous cell carcinoma was expressed in a number of mechanisms.
In esophageal cancer cell lines Eca109 and Ec9706, injection of green tea EGCG plus chemo drug adriamycin (ADM) after 24 hours displayed a significantly increased cellular apoptosis.
According to the flow cytometry assay, the application induced the elevation of ROS and ADM concentration in the production of toxicity to counter the reaction of tumor cells in diminished expression of mitochondrial membrane potential and ABCG2 protein to induce apoptosis, without harm to healthy cells.
ABCG2 protein expression plays a major role in multi-drug resistance, produced by tumor cells to accounter reactions to chemo-medicine.
The mitochondrial membrane potential is a central intermediate in oxidative energy metabolism, the deceased levels caused by toxicity ROS may result in energy depletion and subsequently, cause cells death.
Further observation also indicated that EGCG inhibited the growth of Eca109 and Ec9706 cells through ameliorating the anti-apoptotic bcl-2 protein expression and promoted Bax and caspase-3 protein expressions with functions in induced apoptosis in a dose- and time-dependent manner.
BCL2 family members form hetero- or homodimers and play an important anti-apoptotic protein.
Caspase-3 protein plays a central role in the execution phase of cell apoptosis.
BAX gene. BAX is a member of the Bcl-2 gene family. plays an important role in the mediation of cell death by apoptosis.
Compared to ADM treatment alone, in the Eca109/ABCG2 multi-drug resistance cancer cells, the rate of apoptosis and ADM concentration were significantly higher levels of mitochondrial membrane potential and ABCG2 expression was lower.
In other words, injection of green tea plus ADM was more effective in induced cell death in Eca109/ABCG2 multi-drug resistance cancer cells with expression ROS and ADM in enhanced elevation cytotoxicity activity in compared to ADM treatment alone.
After taking into account other confounders, Dr, Liu L the lead author said, " EGCG inhibited cell growth and induced esophageal cancer cell apoptosis. It reduced the bcl-2 protein expression and increased the bax and caspase-3 protein expression. EGCG reversed multi-drug resistance by reducing ABCG2 expression and increasing the anticancer drug concentration in cancer cells".
In esophageal squamous cell carcinoma, application of Epigallocatechin-3-gallate (EGCG) without ADM measured by flow cytometry assay after 24 hours also inhibited cancer site proliferation by increased expression of ROS to attenuate mitochondrial membrane potential function in energy metabolism and caspase-3 protein to cause malignant cellular apoptosis, in a dose and time-dependent manner.
In the examine the PCR-TRAP argentation analysis during the experiment, EGCG was also demonstrated to inhibit the viability of Eca109 and Ec9706 cells by suppressing cancer cells in alternated DNA transcript through telomerase activity.
More interestingly, the continuation of the study of epigallocatechin-3-gallate (EGCG) on the human esophageal cancer cell line ECa109 also discover that EGCG demonstrated a decrease of cancer cell viability but a substantial rate of apoptosis by increased expression of the p16 gene demethylation in induced cancer cell cycle arrest and apoptosis, level p16 mRNA expression in suppressed tumor progression of invasive and aggressive behavior. and p16 protein expression in promoted tumor suppressible activity, in a dose- and time-dependent manner.
P16 gene demethylation plays an important role in cell cycle arrest and apoptosis. gene alternation was found in several types of cancer.
A low level of p16 mRNA expression is associated with the progression of cancer with malignant and aggressive behavior.
Abnormalities of the p16 gene and loss of p16 protein expression may be related to the pathogenesis and development of some cancers.
Taken together, green tea with an abundance of phytochemical Epigallocatechin-3-gallate (EGCG) may be considered as an adjunct therapy to combine with standard chemo-medicine in reduced risk and treatment of esophageal cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate promotes apoptosis and reversal of multidrug resistance in esophageal cancer cells by Liu L1, Ju Y2, Wang J3, Zhou R3.(PubMed)
(2) Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis in Ec9706 and Eca109 esophageal carcinoma cells by Liu L1, Zuo J1, Wang G1.(PubMed)
(3) Epigallocatechin-3-gallate inhibits growth and induces apoptosis in esophageal cancer cells through the demethylation and reactivation of the p16 gene by Meng J1, Tong Q2, Liu X2, Yu Z3, Zhang J3, Gao B3.(PubMed)
Esophageal cancer is a medical condition characterized by irregular cell growth in the tissues of the esophagus. At the later stage, the cancerous cells may travel a distance away to invade other healthy tissues and organs. According to statistics, 2,300 Canadians will be diagnosed with esophageal cancer in 2017.
In the review of the literature published online, green tea efficacy in the treatment of human esophageal squamous cell carcinoma was expressed in a number of mechanisms.
In esophageal cancer cell lines Eca109 and Ec9706, injection of green tea EGCG plus chemo drug adriamycin (ADM) after 24 hours displayed a significantly increased cellular apoptosis.
According to the flow cytometry assay, the application induced the elevation of ROS and ADM concentration in the production of toxicity to counter the reaction of tumor cells in diminished expression of mitochondrial membrane potential and ABCG2 protein to induce apoptosis, without harm to healthy cells.
ABCG2 protein expression plays a major role in multi-drug resistance, produced by tumor cells to accounter reactions to chemo-medicine.
The mitochondrial membrane potential is a central intermediate in oxidative energy metabolism, the deceased levels caused by toxicity ROS may result in energy depletion and subsequently, cause cells death.
Further observation also indicated that EGCG inhibited the growth of Eca109 and Ec9706 cells through ameliorating the anti-apoptotic bcl-2 protein expression and promoted Bax and caspase-3 protein expressions with functions in induced apoptosis in a dose- and time-dependent manner.
BCL2 family members form hetero- or homodimers and play an important anti-apoptotic protein.
Caspase-3 protein plays a central role in the execution phase of cell apoptosis.
BAX gene. BAX is a member of the Bcl-2 gene family. plays an important role in the mediation of cell death by apoptosis.
Compared to ADM treatment alone, in the Eca109/ABCG2 multi-drug resistance cancer cells, the rate of apoptosis and ADM concentration were significantly higher levels of mitochondrial membrane potential and ABCG2 expression was lower.
In other words, injection of green tea plus ADM was more effective in induced cell death in Eca109/ABCG2 multi-drug resistance cancer cells with expression ROS and ADM in enhanced elevation cytotoxicity activity in compared to ADM treatment alone.
After taking into account other confounders, Dr, Liu L the lead author said, " EGCG inhibited cell growth and induced esophageal cancer cell apoptosis. It reduced the bcl-2 protein expression and increased the bax and caspase-3 protein expression. EGCG reversed multi-drug resistance by reducing ABCG2 expression and increasing the anticancer drug concentration in cancer cells".
In esophageal squamous cell carcinoma, application of Epigallocatechin-3-gallate (EGCG) without ADM measured by flow cytometry assay after 24 hours also inhibited cancer site proliferation by increased expression of ROS to attenuate mitochondrial membrane potential function in energy metabolism and caspase-3 protein to cause malignant cellular apoptosis, in a dose and time-dependent manner.
In the examine the PCR-TRAP argentation analysis during the experiment, EGCG was also demonstrated to inhibit the viability of Eca109 and Ec9706 cells by suppressing cancer cells in alternated DNA transcript through telomerase activity.
More interestingly, the continuation of the study of epigallocatechin-3-gallate (EGCG) on the human esophageal cancer cell line ECa109 also discover that EGCG demonstrated a decrease of cancer cell viability but a substantial rate of apoptosis by increased expression of the p16 gene demethylation in induced cancer cell cycle arrest and apoptosis, level p16 mRNA expression in suppressed tumor progression of invasive and aggressive behavior. and p16 protein expression in promoted tumor suppressible activity, in a dose- and time-dependent manner.
P16 gene demethylation plays an important role in cell cycle arrest and apoptosis. gene alternation was found in several types of cancer.
A low level of p16 mRNA expression is associated with the progression of cancer with malignant and aggressive behavior.
Abnormalities of the p16 gene and loss of p16 protein expression may be related to the pathogenesis and development of some cancers.
Taken together, green tea with an abundance of phytochemical Epigallocatechin-3-gallate (EGCG) may be considered as an adjunct therapy to combine with standard chemo-medicine in reduced risk and treatment of esophageal cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate promotes apoptosis and reversal of multidrug resistance in esophageal cancer cells by Liu L1, Ju Y2, Wang J3, Zhou R3.(PubMed)
(2) Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis in Ec9706 and Eca109 esophageal carcinoma cells by Liu L1, Zuo J1, Wang G1.(PubMed)
(3) Epigallocatechin-3-gallate inhibits growth and induces apoptosis in esophageal cancer cells through the demethylation and reactivation of the p16 gene by Meng J1, Tong Q2, Liu X2, Yu Z3, Zhang J3, Gao B3.(PubMed)
#Honey Potentially Enhances the Chemotherapeutic Effects for the Treatment od #ColonCancer, According to Studies
By Kyle J. Norton
Scientists may have found a sweet functional food that processes a potential for the prevention and treatment of cancer, some studies suggested.
Cancers are the group of chronic diseases, caused by cell growth disorderly and uncontrollably in some specific tissue and organs.
Most primary cancers start in the cells on the surface of the inner lining of tissue caused the alternation of DNA.
At the later stage, after penetrating deep in the tissue of the infected organs, most primary cancer can travel a distance away from the original site to damage other healthy tissue and organs.
As they grow large enough, they can also suppress the nearby tissue and nerve cells, causing severe pain and localized symptoms.
Researchers do not know the exact causes of colon cancer. Neither do they know why some people with the same health conditions, diet patterns and ethnicity, and family history, are susceptible to the early onset of the diseases, while many others do not.
Most common risk factors, epidemiologically are associated with the types of cancer. The National Cancer Institute suggested that aging, tobacco, long-term sun and radiation exposure, chemicals and other substances, some viruses and bacteria, certain hormones, family history of cancer, alcohol, poor diet, lack of physical activity, or being overweight are the common causes of cancer.
In the challenges, the idea that cancer cannot be prevented among older adults, researchers at the National Center for Chronic Disease Prevention and Health Promotion launched a study by examining different aspects of the relationship between age and cancer said, "Although the sequential patterns of aging cannot be changed, several age-related factors that contribute to disease risk can be".
What are the age-related factors that contribute to cancer be changed? researchers continued. "For most adults, age is coincidentally associated with preventable chronic conditions, avoidable exposures, and modifiable risk behaviors that are causally associated with cancer", and "current evidence suggests that for most adults, cancer does not have to be an inevitable consequence of growing older. Interventions that support healthy environments, help people manage chronic conditions, and promote healthy behaviors may help people make a healthier transition from midlife to older age and reduce the likelihood of developing cancer:
These results furtherly emphasized the need to prevent chronic diseases and support a healthy environment and promote a healthy lifestyle in the transition from midlife to the older age are the most important factors that can reduce substantially the risk of cancer.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
With an aim to find a natural ingredient without side effects for the treatment of colon cancer, researchers at the Universiti Kebangsaan Malaysia, launch an investigation to examine the anti-tumor and anti-inflammation properties of crude ginger extract and Gelam honey against many types of cancer, including colorectal cancer.
The cells used in the experiment were divided into 4 groups: the first group represents HT29 cells without treatment, the second and third groups were cells treated singly with either ginger or Gelam honey, respectively, and the last group represents cells treated with ginger and Gelam honey combined.
Combined ginger and Gelam honey treatment stimulated the early cell death response by enhancing the function of proteins associated with programming cell death, namely, the caspase 9 and IκB genes, and inhibiting the function of proteins associated with cell proliferation.
The IC50 of ginger and Gelam honey alone were 5.2 mg/ml and 80 mg/ml, respectively also demonstrated similar efficacy as the IC50 of the combination treatment of 3 mg/ml of ginger plus 27 mg/ml of Gelam honey.
These results suggest ginger and Gelam honey used alone or a combination may be an effective chemopreventive and therapeutic strategy for inducing the death of colon cancer cells.
Further differentiation of the antiproliferative effects of ginger and Gelam honey and their efficacy in enhancing the anti-cancer effects of 5-FU (5-fluorouracil) against a colorectal cancer cell line, HCT 116. researchers showed that
* Ginger (IC50 of 3mg/mL) is more potent than Gelam honey (IC50 of 75 mg/mL) in inhibiting the growth of HCT 116 cells.
* Combined treatment (35 mg/mL) of the two compounds (3mg/mL ginger+75 mg/mL Gelam honey) synergistically lowered the IC50 of Gelam honey to 22 mg/mL without reducing the inhibitory effect against colon cancer cell line.
* Gelam honey markedly enhanced 5-FU inhibiting effects on the growth of HCT 116 cells.
Subsequent analysis on the induction of cellular apoptosis also suggested the individual treatment of ginger and Gelam honey produced higher apoptosis compared to 5-FU alone.
These results once against suggested that Gelam honey and ginger extract used alone or combination could potentially enhance the chemotherapeutic effect of 5-FU against colorectal cancer.
Taken altogether, honey used alone or combined with ginger might process significant and profound effects in reducing the risk of colon cancer and combined with primary therapy for the treatment of colon cancer.
However, further data collection large example size and multi-center studies performed with human consumption of whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of honey anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2, Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(2) Gelam honey and ginger potentiate the anticancer effect of 5-FU against HCT 116 colorectal cancer cells by Hakim L1, Alias E, Makpol S, Ngah WZ, Morad NA, Yusof YA. (PubMed)
(3) Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2, Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(4) Age and Cancer Risk by A Potentially Modifiable Relationship
Mary C. White, ScD, Dawn M. Holman, MPH, Jennifer E. Boehm, MPH, Lucy A. Peipins, PhD, Melissa Grossman, MPH, and S. Jane Henley, MSPH. (PMC)
Scientists may have found a sweet functional food that processes a potential for the prevention and treatment of cancer, some studies suggested.
Cancers are the group of chronic diseases, caused by cell growth disorderly and uncontrollably in some specific tissue and organs.
Most primary cancers start in the cells on the surface of the inner lining of tissue caused the alternation of DNA.
At the later stage, after penetrating deep in the tissue of the infected organs, most primary cancer can travel a distance away from the original site to damage other healthy tissue and organs.
As they grow large enough, they can also suppress the nearby tissue and nerve cells, causing severe pain and localized symptoms.
Researchers do not know the exact causes of colon cancer. Neither do they know why some people with the same health conditions, diet patterns and ethnicity, and family history, are susceptible to the early onset of the diseases, while many others do not.
Most common risk factors, epidemiologically are associated with the types of cancer. The National Cancer Institute suggested that aging, tobacco, long-term sun and radiation exposure, chemicals and other substances, some viruses and bacteria, certain hormones, family history of cancer, alcohol, poor diet, lack of physical activity, or being overweight are the common causes of cancer.
In the challenges, the idea that cancer cannot be prevented among older adults, researchers at the National Center for Chronic Disease Prevention and Health Promotion launched a study by examining different aspects of the relationship between age and cancer said, "Although the sequential patterns of aging cannot be changed, several age-related factors that contribute to disease risk can be".
What are the age-related factors that contribute to cancer be changed? researchers continued. "For most adults, age is coincidentally associated with preventable chronic conditions, avoidable exposures, and modifiable risk behaviors that are causally associated with cancer", and "current evidence suggests that for most adults, cancer does not have to be an inevitable consequence of growing older. Interventions that support healthy environments, help people manage chronic conditions, and promote healthy behaviors may help people make a healthier transition from midlife to older age and reduce the likelihood of developing cancer:
These results furtherly emphasized the need to prevent chronic diseases and support a healthy environment and promote a healthy lifestyle in the transition from midlife to the older age are the most important factors that can reduce substantially the risk of cancer.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
With an aim to find a natural ingredient without side effects for the treatment of colon cancer, researchers at the Universiti Kebangsaan Malaysia, launch an investigation to examine the anti-tumor and anti-inflammation properties of crude ginger extract and Gelam honey against many types of cancer, including colorectal cancer.
The cells used in the experiment were divided into 4 groups: the first group represents HT29 cells without treatment, the second and third groups were cells treated singly with either ginger or Gelam honey, respectively, and the last group represents cells treated with ginger and Gelam honey combined.
Combined ginger and Gelam honey treatment stimulated the early cell death response by enhancing the function of proteins associated with programming cell death, namely, the caspase 9 and IκB genes, and inhibiting the function of proteins associated with cell proliferation.
The IC50 of ginger and Gelam honey alone were 5.2 mg/ml and 80 mg/ml, respectively also demonstrated similar efficacy as the IC50 of the combination treatment of 3 mg/ml of ginger plus 27 mg/ml of Gelam honey.
These results suggest ginger and Gelam honey used alone or a combination may be an effective chemopreventive and therapeutic strategy for inducing the death of colon cancer cells.
Further differentiation of the antiproliferative effects of ginger and Gelam honey and their efficacy in enhancing the anti-cancer effects of 5-FU (5-fluorouracil) against a colorectal cancer cell line, HCT 116. researchers showed that
* Ginger (IC50 of 3mg/mL) is more potent than Gelam honey (IC50 of 75 mg/mL) in inhibiting the growth of HCT 116 cells.
* Combined treatment (35 mg/mL) of the two compounds (3mg/mL ginger+75 mg/mL Gelam honey) synergistically lowered the IC50 of Gelam honey to 22 mg/mL without reducing the inhibitory effect against colon cancer cell line.
* Gelam honey markedly enhanced 5-FU inhibiting effects on the growth of HCT 116 cells.
Subsequent analysis on the induction of cellular apoptosis also suggested the individual treatment of ginger and Gelam honey produced higher apoptosis compared to 5-FU alone.
These results once against suggested that Gelam honey and ginger extract used alone or combination could potentially enhance the chemotherapeutic effect of 5-FU against colorectal cancer.
Taken altogether, honey used alone or combined with ginger might process significant and profound effects in reducing the risk of colon cancer and combined with primary therapy for the treatment of colon cancer.
However, further data collection large example size and multi-center studies performed with human consumption of whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of honey anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2, Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(2) Gelam honey and ginger potentiate the anticancer effect of 5-FU against HCT 116 colorectal cancer cells by Hakim L1, Alias E, Makpol S, Ngah WZ, Morad NA, Yusof YA. (PubMed)
(3) Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells by Tahir AA1, Sani NF2, Murad NA3, Makpol S4, Ngah WZ5, Yusof YA. (PubMed)
(4) Age and Cancer Risk by A Potentially Modifiable Relationship
Mary C. White, ScD, Dawn M. Holman, MPH, Jennifer E. Boehm, MPH, Lucy A. Peipins, PhD, Melissa Grossman, MPH, and S. Jane Henley, MSPH. (PMC)
#Bromelain Improves the Symptoms of Patients with #Endometriosis, According to Clinical Trials
By Kyle J. Norton
Endometriosis is a medical condition characterized by the growth of endometrial cells somewhere else instead of the inside of the uterus.
More precisely, in the last stage of the menstrual cycle, instead of a layer of endometriosis lining on the inside of the uterus expelled, known as menstruation blood, some of the endometriosis tissues grow somewhere in the body.
Most endometriosis tissues do not travel far. Most cases of endometriosis are diagnosed within the pelvic region, on the lining of the peritoneum, in the ovaries, and on the surface of the uterus's outside wall, however, the condition can also be found anywhere in the body as well as fallopian tubes, the cervix, the vagina, and even the vulva.
Believe it or not, about
* 20% of reproductive-age women with endometriosis present without symptoms.
*55% of women have developed the new onset of severe menstrual cramps.
* 25% of women with sub-fertility (less fertile than a normal couple)
Endometriosis can be classified into different stages, depending on the severity of the disease
* Minimal stage:
Commonly they are found on the top surface, of the inside wall of the uterus, ligaments, and ovary with a few in number.
* Mild stage:
For deeper implants, greater numbers are presented. Commonly found in the same area as a minimal stage.
* Moderate stage:
Many implants, and endometrial cysts present, affecting ovary function, and causing scar tissues and adhesion are also present.
* Severe stage:
Intensive peritoneal implants, large endometriomas present, and dense adhesion.
Each woman experiences different endometriosis. Some women may have extensive endometrial tissues in their body but feel little or no pain at all, compared to other women in the early stage of endometriosis with excessive pain.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of endometriosis, researchers evaluated the efficacy of an association of N-acetyl cysteine, alpha-lipoic acid, and bromelain (NAC/LA/Br) in vivo murine model and in vitro human endometriotic endothelial cells (EECs) and on endothelial cells isolated from the normal uterus (UtMECs.
In endometrial cells, EECs preincubated with NAC/LA/Br, levels of pro-inflammatory cytokines associated with TNF-α were significantly reduced observed by lower expression of the inflammatory "marker" VCAM1.
On human endometriotic cysts intraperitoneally in SCID mice, NAC/LA/Br exerted a strong apoptotic activity against EECs without affecting the endothelial cells isolated from the normal uterus (UtMECs).
Furthermore, compared to untreated mice, mice treated with NAC/LA/Br presented a lower number of cysts, smaller in size.
Based on the findings, researchers said, "These dietary supplements may have potential therapeutic uses in the treatment of chronic inflammatory diseases like endometriosis".
Moreover, in order to reveal more information about NAC/LA/Br on symptoms of endometriosis, researchers examined the effect of N-acetyl cysteine, alpha lipoic acid, and bromelain on endometriosis- pelvic pain.
In a total of 398 patients with a mean age of 34.6 ± 7.2 years, treatment of the combination of N-acetyl cysteine, alpha lipoic acid, and bromelain for 6 months showed a significant improvement in endometriosis-associated pelvic pain compared to the baseline.
More precisely, compared to the baseline of 92.7% of the patients had pain intensity > 4 on the visual analog scale (VAS); treatment of NAC/LA/Br at 3 months decreased the percentage of patients to 87.2% (p = 0.074) and at 6 months to 82.7%, respectively.
Dr. Lete I, the lead scientist said, "Women with endometriosis who wish to become pregnant and are treated with a preparation containing N-acetyl cysteine, alpha lipoic acid, and bromelain experienced a significant improvement in endometriosis-associated pelvic pain and required lower intake of rescue analgesics".
Taken altogether, bromelain combined with conventional medicine may be considered a remedy for the prevention and treatment of endometriosis and endometrial symptoms, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study by Lete I1, Mendoza N2, de la Viuda E3, Carmona F. (PubMed)
(2) The combination of N-acetyl cysteine, alpha-lipoic acid, and bromelain shows high anti-inflammatory properties in novel in vivo and in vitro models of endometriosis by Agostinis C1, Zorzet S2, De Leo R1, Zauli G1, De Seta F3, Bulla R. (PubMed)
(3) Endometriosis part I - Definition, Stages, Symptoms, Causes, and Effects Of Endometriosis by Kyle J. Norton
Endometriosis is a medical condition characterized by the growth of endometrial cells somewhere else instead of the inside of the uterus.
More precisely, in the last stage of the menstrual cycle, instead of a layer of endometriosis lining on the inside of the uterus expelled, known as menstruation blood, some of the endometriosis tissues grow somewhere in the body.
Most endometriosis tissues do not travel far. Most cases of endometriosis are diagnosed within the pelvic region, on the lining of the peritoneum, in the ovaries, and on the surface of the uterus's outside wall, however, the condition can also be found anywhere in the body as well as fallopian tubes, the cervix, the vagina, and even the vulva.
Believe it or not, about
* 20% of reproductive-age women with endometriosis present without symptoms.
*55% of women have developed the new onset of severe menstrual cramps.
* 25% of women with sub-fertility (less fertile than a normal couple)
Endometriosis can be classified into different stages, depending on the severity of the disease
* Minimal stage:
Commonly they are found on the top surface, of the inside wall of the uterus, ligaments, and ovary with a few in number.
* Mild stage:
For deeper implants, greater numbers are presented. Commonly found in the same area as a minimal stage.
* Moderate stage:
Many implants, and endometrial cysts present, affecting ovary function, and causing scar tissues and adhesion are also present.
* Severe stage:
Intensive peritoneal implants, large endometriomas present, and dense adhesion.
Each woman experiences different endometriosis. Some women may have extensive endometrial tissues in their body but feel little or no pain at all, compared to other women in the early stage of endometriosis with excessive pain.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of endometriosis, researchers evaluated the efficacy of an association of N-acetyl cysteine, alpha-lipoic acid, and bromelain (NAC/LA/Br) in vivo murine model and in vitro human endometriotic endothelial cells (EECs) and on endothelial cells isolated from the normal uterus (UtMECs.
In endometrial cells, EECs preincubated with NAC/LA/Br, levels of pro-inflammatory cytokines associated with TNF-α were significantly reduced observed by lower expression of the inflammatory "marker" VCAM1.
On human endometriotic cysts intraperitoneally in SCID mice, NAC/LA/Br exerted a strong apoptotic activity against EECs without affecting the endothelial cells isolated from the normal uterus (UtMECs).
Furthermore, compared to untreated mice, mice treated with NAC/LA/Br presented a lower number of cysts, smaller in size.
Based on the findings, researchers said, "These dietary supplements may have potential therapeutic uses in the treatment of chronic inflammatory diseases like endometriosis".
Moreover, in order to reveal more information about NAC/LA/Br on symptoms of endometriosis, researchers examined the effect of N-acetyl cysteine, alpha lipoic acid, and bromelain on endometriosis- pelvic pain.
In a total of 398 patients with a mean age of 34.6 ± 7.2 years, treatment of the combination of N-acetyl cysteine, alpha lipoic acid, and bromelain for 6 months showed a significant improvement in endometriosis-associated pelvic pain compared to the baseline.
More precisely, compared to the baseline of 92.7% of the patients had pain intensity > 4 on the visual analog scale (VAS); treatment of NAC/LA/Br at 3 months decreased the percentage of patients to 87.2% (p = 0.074) and at 6 months to 82.7%, respectively.
Dr. Lete I, the lead scientist said, "Women with endometriosis who wish to become pregnant and are treated with a preparation containing N-acetyl cysteine, alpha lipoic acid, and bromelain experienced a significant improvement in endometriosis-associated pelvic pain and required lower intake of rescue analgesics".
Taken altogether, bromelain combined with conventional medicine may be considered a remedy for the prevention and treatment of endometriosis and endometrial symptoms, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study by Lete I1, Mendoza N2, de la Viuda E3, Carmona F. (PubMed)
(2) The combination of N-acetyl cysteine, alpha-lipoic acid, and bromelain shows high anti-inflammatory properties in novel in vivo and in vitro models of endometriosis by Agostinis C1, Zorzet S2, De Leo R1, Zauli G1, De Seta F3, Bulla R. (PubMed)
(3) Endometriosis part I - Definition, Stages, Symptoms, Causes, and Effects Of Endometriosis by Kyle J. Norton
#Healthyfood #Tomatoes in the Promotion of Healthy Ratio of #GutMicrobiota For Optimal Health, Researchers say
By Kyle J. Norton
Gut Microbiota is a community of microorganisms living in the gastrointestinal tract.
Under normal conditions, gut microbiota plays a critical role in overall health, including the impacts of
* In nutrient metabolism, gut microbiota improves the absorption of dietary nutrients in the digestive system
* In xenobiotic and drug metabolism, gut microbiota protects the body against xenobiotics and drug toxicity by facilitating excretion.
* Maintenance of the structural integrity of the gut mucosal barrier, gut microbiota enhances the epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of the intestine in nutrient adsorption.
* In immunomodulation, gut microbiota interact with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
However, an imbalanced ratio of gut microbiota may have a negative on human health and diseases.
Dr. Yu-Jie Zhang wrote, "Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function".
And, "However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism".
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods for enhancing the ratio of dut microbiota composition researchers examined the effect of consuming tomato products and lycopene on chronic inflammatory disorders associated with intestinal bacteria in an animal model.
The study included Winnie mice as a model of spontaneous ulcerative colitis treated with or without chow enriched with 1% Bronze tomato.
At week 2, the Bronze-enriched chow-treated group showed no macroscopic effect on the IBD symptoms.
However, levels of pro-inflammatory cytokines found in the treated mice were significantly reduced, observed by the levels of IL17A and IFNγ.
According to the analysis of the microbial composition, two weeks of the Bronze enriched diet demonstrated a strong effect in the improvement of the gut microbiota ratio in the tested mice.
In additional differentiation of the results, researchers found that the efficacy of the Bronze tomato in the promotion of gut health was attributed to the phytochemical polyphenols presented in the tomato.
Taken altogether, tomatoes processed high amounts of lycopene may be considered a dietary supplement for gut health, pending to large sample size and multicenter human study.
Intake of polyphenols in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition by Lahiani MH 1, Khare S, Cerniglia CE, Boy R, Ivanov IN, Khodakovskaya M. (PubMed)
(2) A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions.
Liso M1, De Santis S2, Scarano A3, Verna G4, Dicarlo M5, Galleggiante V6, Campiglia P7, Mastronardi M8, Lippolis A9, Vacca M10, Sobolewski A11, Serino G12, Butelli E13, De Angelis M14, Martin C15, Santino A16, Chieppa M. (PubMed)
(3) Impacts of Gut Bacteria on Human Health and Diseases by Yu-Jie Zhang,1 Sha Li,2 Ren-You Gan,3 Tong Zhou,1 Dong-Ping Xu,1 and Hua-Bin Li. (PMC)
Gut Microbiota is a community of microorganisms living in the gastrointestinal tract.
Under normal conditions, gut microbiota plays a critical role in overall health, including the impacts of
* In nutrient metabolism, gut microbiota improves the absorption of dietary nutrients in the digestive system
* In xenobiotic and drug metabolism, gut microbiota protects the body against xenobiotics and drug toxicity by facilitating excretion.
* Maintenance of the structural integrity of the gut mucosal barrier, gut microbiota enhances the epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of the intestine in nutrient adsorption.
* In immunomodulation, gut microbiota interact with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
However, an imbalanced ratio of gut microbiota may have a negative on human health and diseases.
Dr. Yu-Jie Zhang wrote, "Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function".
And, "However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism".
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods for enhancing the ratio of dut microbiota composition researchers examined the effect of consuming tomato products and lycopene on chronic inflammatory disorders associated with intestinal bacteria in an animal model.
The study included Winnie mice as a model of spontaneous ulcerative colitis treated with or without chow enriched with 1% Bronze tomato.
At week 2, the Bronze-enriched chow-treated group showed no macroscopic effect on the IBD symptoms.
However, levels of pro-inflammatory cytokines found in the treated mice were significantly reduced, observed by the levels of IL17A and IFNγ.
According to the analysis of the microbial composition, two weeks of the Bronze enriched diet demonstrated a strong effect in the improvement of the gut microbiota ratio in the tested mice.
In additional differentiation of the results, researchers found that the efficacy of the Bronze tomato in the promotion of gut health was attributed to the phytochemical polyphenols presented in the tomato.
Taken altogether, tomatoes processed high amounts of lycopene may be considered a dietary supplement for gut health, pending to large sample size and multicenter human study.
Intake of polyphenols in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition by Lahiani MH 1, Khare S, Cerniglia CE, Boy R, Ivanov IN, Khodakovskaya M. (PubMed)
(2) A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions.
Liso M1, De Santis S2, Scarano A3, Verna G4, Dicarlo M5, Galleggiante V6, Campiglia P7, Mastronardi M8, Lippolis A9, Vacca M10, Sobolewski A11, Serino G12, Butelli E13, De Angelis M14, Martin C15, Santino A16, Chieppa M. (PubMed)
(3) Impacts of Gut Bacteria on Human Health and Diseases by Yu-Jie Zhang,1 Sha Li,2 Ren-You Gan,3 Tong Zhou,1 Dong-Ping Xu,1 and Hua-Bin Li. (PMC)
#Curcumin Found in Herbal Turmeric Inhibits #Parkinson's disease through Its Antiinflammatory Effects, In Vivos
By Kyle J. Norton
Dementia is a medical and neurodegenerative disease characterized by the loss of mental ability, that is severe enough to interfere with people's every life including Alzheimer's disease and Parkinson's disease (PD), the most common types of dementia in aging people.
Dementia accounts for 5-8% of all people over the age of 65, and this number doubles every five years.
Parkinson's disease (PD) is a type of dementia that affects the nerve cells associated with the production of dopamine in the brain, leading to muscle rigidity, tremors, and changes in speech and gait.
In other words, Parkinson's disease is a progressive neurological disorder that affects neurons in transmitting messages in controlling movement.
In the very early stage of PD, patients may not experience any symptoms. However, Parkinson's disease symptoms gradually worsen as the condition progresses.
As of today, researchers do not know why the neurons in the brain in some people are susceptible to gradually breaking down or dying while others do not even if they have similar health conditions and are from the same family.
Epidemiologically aging, gender, long-term exposure to certain toxic chemicals, and genetic deposition are some of the prevalent factors involved in the increased risk of the disease.
Some researchers in the examination of the dietary habits in different parts of the world suggested that people who drink green tea regularly, are less likely to get Parkinson's disease compared to those who don't.
Dr. Jurado-Coronel, the lead scientist at the Pontificia Universidad Javeriana wrote, wrote, "This (green tea) beverage is prepared from the leaves (steamed and dried) of the Camellia Sinensis plant and contains strong antioxidant and neuroprotective phenolic compounds from which the most important is (-)-Epigallocatechin-3-gallate"
And, " Parkinson's disease (PD) is the second more common neurodegenerative disorder, after Alzheimer's disease, and is characterized by degeneration of dopaminergic neurons in the pars compacta of the substantia nigra of the basal ganglia. It has been shown in pre-clinical and clinical studies that green tea may be able to prevent PD".
The results strongly suggested if you drink green tea, your risk of PD is decreased substantially.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
On finding a potent ingredient for the treatment of neurological disease, researchers examined the effects of Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa on Parkinson's disease (PD) in an animal model.
According to the 13 studies with a total of 298 animals describing the efficacy of curcumin in animal models of PD were selected by searching the online medical literature,* The majority of the experimental studies suggested that curcumin processes significant neuroprotection for the treatment of PD compared to the control group.
* 5 selected studies indicated that curcumin had an anti-inflammatory effect in the PD animal models.
* Furthermore,, four studies suggested that curcumin processes antioxidant capacity in the protection of substantia nigra neurons and improvement striatal dopamine levels in PD animal models.
* Additionally, two studies also displayed that curcumin treatment was also effective in reducing neuronal apoptosis and improving functional outcomes in animal models of PD.
Based on the findings, researchers said, "Most of the preclinical studies demonstrated the positive findings while one study reported that curcumin had no beneficial effects against Mn-induced disruption (induced neurotoxicity) of hippocampal metal and neurotransmitter homeostasis"
And, "The results demonstrated a marked efficacy of curcumin in an experimental model of PD, suggesting curcumin probably a candidate neuroprotective drug for human PD patients".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of Parkinson's disease (PD), pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chronic dietary supplementation with turmeric protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-mediated neurotoxicity in vivo: implications for Parkinson's disease by Mythri RB1, Veena J, Harish G, Shankaranarayana Rao BS, Srinivas Bharath MM. (PubMed)
(2) Neuroprotective properties of curcumin in toxin-base animal models of Parkinson's disease: a systematic experiment literatures review by Wang XS1, Zhang ZR1, Zhang MM1, Sun MX2, Wang WW3, Xie CL. (PubMed)
(3) The implication of Green Tea as a Possible Therapeutic Approach for Parkinson Disease by Jurado-Coronel JC, Ávila-Rodriguez M, Echeverria V, Hidalgo OA, Gonzalez J, Aliev G, Barreto GE. (PubMed)
Dementia is a medical and neurodegenerative disease characterized by the loss of mental ability, that is severe enough to interfere with people's every life including Alzheimer's disease and Parkinson's disease (PD), the most common types of dementia in aging people.
Dementia accounts for 5-8% of all people over the age of 65, and this number doubles every five years.
Parkinson's disease (PD) is a type of dementia that affects the nerve cells associated with the production of dopamine in the brain, leading to muscle rigidity, tremors, and changes in speech and gait.
In other words, Parkinson's disease is a progressive neurological disorder that affects neurons in transmitting messages in controlling movement.
In the very early stage of PD, patients may not experience any symptoms. However, Parkinson's disease symptoms gradually worsen as the condition progresses.
As of today, researchers do not know why the neurons in the brain in some people are susceptible to gradually breaking down or dying while others do not even if they have similar health conditions and are from the same family.
Epidemiologically aging, gender, long-term exposure to certain toxic chemicals, and genetic deposition are some of the prevalent factors involved in the increased risk of the disease.
Some researchers in the examination of the dietary habits in different parts of the world suggested that people who drink green tea regularly, are less likely to get Parkinson's disease compared to those who don't.
Dr. Jurado-Coronel, the lead scientist at the Pontificia Universidad Javeriana wrote, wrote, "This (green tea) beverage is prepared from the leaves (steamed and dried) of the Camellia Sinensis plant and contains strong antioxidant and neuroprotective phenolic compounds from which the most important is (-)-Epigallocatechin-3-gallate"
And, " Parkinson's disease (PD) is the second more common neurodegenerative disorder, after Alzheimer's disease, and is characterized by degeneration of dopaminergic neurons in the pars compacta of the substantia nigra of the basal ganglia. It has been shown in pre-clinical and clinical studies that green tea may be able to prevent PD".
The results strongly suggested if you drink green tea, your risk of PD is decreased substantially.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
On finding a potent ingredient for the treatment of neurological disease, researchers examined the effects of Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa on Parkinson's disease (PD) in an animal model.
According to the 13 studies with a total of 298 animals describing the efficacy of curcumin in animal models of PD were selected by searching the online medical literature,* The majority of the experimental studies suggested that curcumin processes significant neuroprotection for the treatment of PD compared to the control group.
* 5 selected studies indicated that curcumin had an anti-inflammatory effect in the PD animal models.
* Furthermore,, four studies suggested that curcumin processes antioxidant capacity in the protection of substantia nigra neurons and improvement striatal dopamine levels in PD animal models.
* Additionally, two studies also displayed that curcumin treatment was also effective in reducing neuronal apoptosis and improving functional outcomes in animal models of PD.
Based on the findings, researchers said, "Most of the preclinical studies demonstrated the positive findings while one study reported that curcumin had no beneficial effects against Mn-induced disruption (induced neurotoxicity) of hippocampal metal and neurotransmitter homeostasis"
And, "The results demonstrated a marked efficacy of curcumin in an experimental model of PD, suggesting curcumin probably a candidate neuroprotective drug for human PD patients".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of Parkinson's disease (PD), pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chronic dietary supplementation with turmeric protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-mediated neurotoxicity in vivo: implications for Parkinson's disease by Mythri RB1, Veena J, Harish G, Shankaranarayana Rao BS, Srinivas Bharath MM. (PubMed)
(2) Neuroprotective properties of curcumin in toxin-base animal models of Parkinson's disease: a systematic experiment literatures review by Wang XS1, Zhang ZR1, Zhang MM1, Sun MX2, Wang WW3, Xie CL. (PubMed)
(3) The implication of Green Tea as a Possible Therapeutic Approach for Parkinson Disease by Jurado-Coronel JC, Ávila-Rodriguez M, Echeverria V, Hidalgo OA, Gonzalez J, Aliev G, Barreto GE. (PubMed)
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