#GreenTea's #Polyphenol #EGCG Reduces the Risk of #ColonCancer Through Their Effects on Retinoid X receptor-alpha (#RXRα)

By Kyle J. Norton

Colon cancer is a medical condition caused by cell growth disorderly and uncontrollably in the colon tissues. At the later stage, the cancerous cell may travel a distance away to infect other healthy organs and tissues.

In the review of medical literature published online, green tea efficacy in reduced risk and treatment of colon cancer may be associated with the bioactive polyphenol EGCG expression in the promoted and
decreased certain interactions in the cell profiles through various mechanisms.

According to the study by the University College of Medicine, Seoul, the application of EGCG on HT-29 colon cancer cells showed a significant effect in the inhibition of cell cycle progression of protein in COX-2 expression. through activation of AMPK activity in promoted metabolic tumor suppressor by regulating energy levels, enforcing metabolic checkpoints, and inhibiting cell growth.

Cyclooxygenase(COX)-2, is an enzyme with the function of speeding up the production of hormone prostaglandins in regulated cell proliferation and cell apoptosis.

AMPK(5' AMP-activated protein kinase) plays a role in cellular energy homeostasis, activation of AMPK may result in tumor growth inhibition, cell cycle arrest, and apoptosis of cancer cells in some tumor types/contexts.

Additionally, in inhibition of COX-2 expression green tea EGCG reduced prostaglandin E(2) secretion, thus reducing the risk of Prostaglandin E2 (PGE2) in modulated angiogenesis, including the process of new blood vessel formation, promoted proliferation, migration, and formation of endothelial cells, lining the interior surface of blood vessels and lymphatic vessels.

The study also emphasized that inhibiting AMPK by an AMPK inhibitor may interrupt the function of the bioactive compound in initiating such changes.

Continuously, the activation of the enzyme AMPK also had a strong implication on VEGF (vascular endothelial growth factor) and glucose transporter in facilitating the transport of glucose over a plasma membrane and Glut-1 in facilitating the transport of glucose across the plasma membranes of mammalian cells in EGCG-treated cancer cells.

Further analysis and application of EGCG-activated AMPK enzyme also modulated the production of ROS without causing ROS expression in initiated tumor progression and damage to cellular structures, such as the lipid membrane, protein, and nucleic acid but inducing cancer cells DNA mutations and compromised genome integrity, subsequently in cancer cells senescence and death.


In another aspect of colon cancer study in an animal model, diminished levels of retinoid X receptor-alpha (RXRα) in regulated cancer cell growth and modulated suppressed tumorigenesis may have a profound effect on cell proliferation.

Application of green tea bioactive EGCG expressed a significant effect in restoring RXRα protein and expression levels caused by methylation function in alternating the activity of a DNA segment without changing the sequence, thus reducing the risk of cancer expansion.

Additional differentiation also suggested that EGCG-induced methylation changes in several other colon cancer-related genes restore the levels of RXRα without causing a decrease in global methylation in maintaining the epigenetic state of individual genes.

Change of globe methylation expression is found to associate with the occurrence of cancer.

Retinoid X receptor-alpha (RXRα) is a nuclear receptor with function in regulated cancer proliferation and modulated suppression of tumorigenesis.

Based on the results finding, EGCG with a novel therapeutic effect on common and on chemo-resistant colon cancer cells may be considered as a secondary application used a combination with chemotherapeutic agents, 5-FU for the treatment of any type of colon cancer

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Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway by Hwang JT1, Ha J, Park IJ, Lee SK, Baik HW, Kim YM, Park OJ.(PubMed)
(2) Reduction in promotor methylation utilizing EGCG (epigallocatechin-3-gallate) restores RXRα expression in human colon cancer cells by Morris J1, Moseley VR2, Cabang AB1, Coleman K2, Wei W3, Garrett-Mayer E4, Wargovich MJ1.(PubMed)
(3) Global Methylation in Exposure Biology and Translational Medical Science by Heather H. Nelson,1,2 Carmen J. Marsit,3,4 and Karl T. Kelsey4,5(PubMed)

#Herbal #Bilberry's Flavonoids #Exerts Neuro- & Mitochondrial-Protective Effects Aganist the Risk of #Parkinson's disease (PD)

By Kyle J. Norton

Parkinson's disease (PD) is a chronic medical condition that affects the nerve cells associated with the production of dopamine in the brain, leading to muscle rigidity, tremors, and changes in speech and gait.
In other words, Parkinson's disease is a progressive central nervous system disorder that affects neurons in transmitting messages in controlling movement.

Some patients in the early stage of PD may not experience any symptoms. However, Parkinson's disease symptoms gradually worsen as the condition progresses.

Researchers do not know why the neurons in the brain in some people are susceptible to gradually breaking down or dying while others do not even have similar health conditions and are from the same family.

However, they do know, according to the epidemiological study, aging, gender, long-term exposure to certain toxic chemicals and genetic deposition are some of the risk factors found in patients with PD.

Please note that most people who process some conditions have never developed Parkinson's disease.

Some researchers in the examination of the dietary habits in different parts of the world suggested that people who drink caffeine found in coffee, tea and cola are less likely to get Parkinson's disease compared to those who don't.

Dr. Prediger RD at the Universidade Federal de Santa Catarina wrote, "Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting approximately 1% of the population older than 60 years".

And, "The available data also suggest that caffeine can improve the motor deficits of PD and that adenosine A2A receptor antagonists such as istradefylline reduces OFF time and dyskinesia associated with standard 'dopamine replacement' treatments".

The results strongly suggested if you drink caffeinated beverages, your risk of PD is decreased substantially.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

With an aim to find a natural ingredient which processes neuroprotective effects against Parkinson's disease, researchers examined the Anthocyanin-rich preparations of Vaccinium species, including bilberry against the oxidative damage in dopaminergic neurons.

V. myrtillus preparation: 50% inhibition with 7 microM of total anthocyanins showed a significant neuron protection activity by inhibiting oxidation caused by the chain reaction of reactive oxygen species (ROS).

The application was found to be 1.5-4 times higher than that for the other preparations or for the purified anthocyanin.

According to the analysis of the chemical constituents, the neuroprotective effects were attributed to the presence of bioactive compounds anthocyanins and total cyanidins found abundantly in bilberry, but not quercetin or myricetin.

The results suggested that the high potency of anthocyanins processes a potentially neurotoxic reaction against the onset of Parkinson's disease.

Dr. Yao Y, the lead scientist wrote, "(the findings) provide a basis for in vivo testing of these flavonoids and their physiological metabolites in the context of neuro- and mitochondrial-protective effects".

Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functioning remedy for the treatment of Parkinson's disease, pending to the validation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Magnetic resonance imaging as a tool to image neuroinflammation in a rat model of Parkinson's disease--phagocyte influx to the brain is promoted by bilberry-enriched diet by Virel A1, Rehnmark A1, Orädd G2, Olmedo-Díaz S1, Faergemann E1, Strömberg I. (PubMed)
(2) Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity by Yao Y1, Vieira A. (PubMed)
(3) Effects of caffeine in Parkinson's disease: from neuroprotection to the management of motor and non-motor symptoms by Prediger RD. (PubMed)

#Antioxidant #Lycopene Inhibits Proteins and Pro-Inflammatory Cytokines in Post #MyocardialInfarction Complications

By Kyle J. Norton

Acute brain infarction is a severe medical emergency characterized by the obstruction of the blood supply to the brain, causing local death of the neurons in the brain. Prompt treatment can minimize brain damage and potential complications.
The occurrence and extent of brain infarction are associated with three basic factors, including the site of arterial occlusion, the rapidity of arterial occlusion, and the presence or absence of collateral circulation.

In other words, brain infarction can be classified into myocardial infarction due to plaque rupture and myocardial oxygen supply-demand imbalance secondary to other acute illnesses.

The exact causes of a blood clot to induce acute brain infarction are unknown. However, trouble with speaking and understanding, confusion, sudden numbness, weakness or paralysis in your face, arm, or leg, headache, and trouble with walking are some of the most common symptoms found in patients with post-myocardial infarction.

Depending on the severity of the acute infarction, in serious cases, patients may also experience symptoms, paralysis of the face, arm, or leg, and trouble with seeing in one or both eyes.

Although, there are many factors associated with the risk of acute infarction. some researchers suggested aging may have a strong and negative implication on acute infarction.

Dr. Amelia Carro, the lead scientist wrote, "Data from 163,140 hospital admissions of Medicare beneficiaries age > or =65 years between 1994 and 1996 with AMI at U.S. hospitals were evaluated for differences in clinical characteristics and mortality across five age-based strata (in years): 65 to 69, 70 to 74, 75 to 79, 80 to 84 and > or =85".

And, "Our data indicate significant age-associated differences in clinical characteristics in elderly patients with AMI, which account for some of the age-associated differences in mortality".

Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas.

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

In finding a natural compound for the treatment of post-heart attack, researchers examined supplementation on cardiac remodeling after myocardial infarction (MI).

The study included male Wistar rats assigned randomly into four groups: the sham group (animals that underwent simulated surgery) that received a standard chow (S; n=18), the infarcted group that received a standard chow (MI; n=13), the infarcted group supplemented with lycopene (1 mg of lycopene/kg body weight/day) (MIL; n=16) and the infarcted group supplemented with tomato (MIT; n=16).

At the end of 3 months of the experiment, based on the assay analysis, researchers found that* The groups MIL and MIT showed decreased interstitial fibrosis induced by infarction.

* Tomato treated group attenuated the hypertrophy induced by MI.

* Lycopene reduced the expression of proteins and pathways associated with pro-inflammatory cytokines such as TGF-β1, and NF-κB, and TNF-α respectively, collagen I, and collagen III associated with the initiation of fibrous tissues.

* Most importantly, lycopene also ameliorated the level of ventricular remodeling post-MI.

Based on the findings, researchers said, "Lycopene may inhibit the NF-κB signaling pathway thereby reducing the inflammatory response and cardiomyocyte apoptosis post-MI, which could be a key mechanism of lycopene in attenuating ventricular remodeling".

Taken altogether, lycopene found in tomatoes may be considered a supplement for the treatment of cardio-remodeling in post-myocardial infarction, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tomato (Lycopersicon esculentum) or lycopene supplementation attenuates ventricular remodeling after myocardial infarction through different mechanistic pathways by Pereira BLB1, Reis PP2, Severino FE3, Felix TF4, Braz MG5, Nogueira FR6, Silva RAC7, Cardoso AC8, Lourenço MAM9, Figueiredo AM10, Chiuso-Minicucci F11, Azevedo PS12, Polegato BF13, Okoshi K14, Fernandes AAH15, Paiva SAR16, Zornoff LAM17, Minicucci MF. (PubMed)
(2) Lycopene attenuates inflammation and apoptosis in post-myocardial infarction remodeling by inhibiting the nuclear factor-κB signaling pathway by He Q1, Zhou W1, Xiong C1, Tan G1, Chen M. (PubMed)
(3) Acute myocardial infarction in the elderly: differences by age by Mehta RH1, Rathore SS, Radford MJ, Wang Y, Wang Y, Krumholz HM. (PubMed)

#Cranberry Inhibits the Risk of Bladder Cystitis & Urinary Symptoms of #ProstateCancer Patients Receiving Radiation Therapy

By Kyle J. Norton

The bladder-formed part of the secretary system is a muscular sac in the pelvis, just above and behind the pubic bone, playing a critical role for collect and secret urine made by the kidneys.

Cystitis is a medical condition associated with inflammation of the bladder, leading to the symptoms of bladder irritation and swelling. Women are prone to the condition compared to men.

Bladder cystitis or bladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic syndrome associated with pelvic pain urgency and frequency. The condition is not considered a disease due to the difficulty to rule out all differential diagnoses only from history.

The most common cause of bladder cystitis is a bacterial infection involved in the urinary tract. However, radiotherapy, long-term use of certain medicines, and hygiene products have also been found to induce bladder inflammation.

The most common symptoms of cystitis are frequent urge to urinate, urge to urinate after you’ve emptied your bladder, cloudy or strong-smelling urine, pain during sexual intercourse, and sensations of pressure or bladder fullness.

In serious cases, patients may also experience symptoms of fever, blood in their urine, and cramping in their abdomen or back.

Conventionally, antibiotics are the first line of treatment for bladder cystitis, if the bacteria that cause the infection has been identified.

Most cases of acute cystitis are treated by nitrofurantoin monohydrate/macrocrystals, trimethoprim-sulfamethoxazole (TMP-SMX) accompanied by nonsteroidal anti-inflammatory drugs, such as ibuprofen (Advil) or acetaminophen (Tylenol) to reduce pain and inflammation.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of prostate diseases, researchers examined the effect of highly standardized cranberry capsules (containing 72 mg proanthocyanidins [PACS]) compared with that placebo capsules on the incidence and severity of radiation cystitis.

A total of 41 men with prostate cancer participated in a double-blinded randomized placebo-controlled study, taking one capsule a day at breakfast during treatment and for 2 weeks after treatment completion, researchers, according to the tested analysis found that

Cranberry capsules show a significantly reduced incidence of cystitis to 65% compared to placebo capsules of 90%.

Severe cystitis is only present in 30% of men in the cranberry arm and 45% of the placebo.

Overall, the incidence of pain/burning is significantly lower in the cranberry compared to the placebo.

Additionally, cranberry injection shows less pain/burning, a stronger urine stream, and used significantly fewer pads/liners, in men on the low hydration regimen comapred to those on the high hydration regimen.

Based on the findings, researchers concluded. "Men receiving radiation therapy for prostate cancer may benefit from using cranberry capsules, particularly those on low hydration regimens or with baseline urinary symptoms".

Taken altogether, cranberry may be considered a remedy for the prevention and treatment of cystitis.in prostate cancer patients, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Standardized cranberry capsules for radiation cystitis in prostate cancer patients in New Zealand: a randomized double-blinded, placebo-controlled pilot study by Hamilton K1, Bennett NC, Purdie G, Herst PM. (PubMed)
(2) Cranberry and recurrent cystitis: more than marketing? by Micali S1, Isgro G, Bianchi G, Miceli N, Calapai G, Navarra M. (PubMed)

#Greentea Extract, Attenuates the Risk of #AutoimmuneDiseases by Its Antioxidant Activities, According to Studies

By Kyle J. Norton

Green tea bioactive Epigallocatechin-3-gallate (EGCG) may have a therapeutic and profound effect in attenuated risk and treatment of autoimmune diseases, some scientists postulated.
Autoimmune diseases are class of diseases characterized by the immune system attacking its own tissues.

Green tea bioactive compound Epigallocatechin-3-gallate (EGCG) in the risk of autoimmune diseases was found to associate with many different mechanisms involved numbers of aspect.

In interleukin-1 receptor antagonist knockout (IL-1raKO) arthritis rodent models of human rheumatoid arthritis, intraperitoneal injection of EGCG three times per week after the first immunization showed a significant reduction of arthritis index observed by decreased damage and destruction of joint tissues.

The efficacy of green tea phytochemicals in inhibited arthritis expression was attributed to the activities in reduced production of pro-inflammatory cytokines in accumulation of inflammatory cells into the synovium for joint destruction and oxidative stress proteins in facilitated inflammation and destruction of the joints in arthritis.

Furthermore, the extract also exhibited anti-STAT3 expression in a mediated variety of genes in response to cell stimuli to induce cellular processes such as cell growth and division, cell movement, and apoptosis activated by cytokine-dependent inflammation, through phosphorylation-Stat3 Antibody (y705) and (S727)in shortening the duration of STAT3 activity.

Interestingly, the additional analysis also found that the application of green tea bioactive compound lowers the mediation effect of mammalian target of rapamycin (mTOR) function in limited production of pro-inflammatory cytokines and hypoxia-inducible factor 1 (HIF-1) in the regulation of vascular endothelial growth factor (VEGF) function in the activated pro-inflammatory expression in innate immunity.

Moreover, injection of EGCG also exhibited anti-osteoclastic activity observed by reduced osteoclast markers in EGCG-treated IL-1RaKO mice.

In mice induced Sjögren's syndrome with pathogenic effects of reactive oxygen species (ROS) in the salivary glands, administration of green tea Epigallocatechin gallate (EGCG), was found to reduce overexpression of ROS in precipitated oxidative stress-induced DNA damage and apoptosis in MRL-Fas(lpr) mice with autoimmune sialadenitis through Heme oxygenase(HO)-1 in response to pro antioxidant expression and Bcl-2 with function to induce cell survival.

Additionally, in the investigation of the ameliorated effects of green tea on the risk of autoimmune sialadenitis in a murine model, the application of the green tea extract chemical compound decreased the severity of sialadenitis substantially through reduced expressions of Thymine glycol (5,6-dihydroxy-5,6-dihydrothymine) with function in induced DNA damage by oxidation and ionizing radiation andgp91phox subunit of NADPH oxidase in the production of ROS to react to the acute phase of infection.

Further differentiation indicated that the chemical constituents also ameliorated single-stranded DNA (ssDNA) function in DNA duplication in both viruses and organisms and cleaved caspase 3 activity in the mediation of programmed cell death and TP53 or tumor protein in regulated apoptosis mediated by expression of BAX.

More profoundly, in the examine duct epithelial cells of salivary glands, EGCG-treated mice showed decreased levels of SS-A/Ro, an extractable nuclear antigen (ENA) and Sjögren syndrome antigen B or Lupus La protein (SSB/La) associated with autoimmune diseases such as systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS).

Finally, green tea EGCG-treated mice also showed a lower Ifi202b interferon activated gene 202B expression in implicated the development of systemic lupus erythematosus (SLE) and Ifi202 overexpression in the kidney and immune organs, an indication of significantly increased disease progression in autoimmune glomerulonephritis, according to the publication of Gene ID: 26388, updated on 5-Nov-2017.

Taken together, green tea processed abundantly bioactive phytochemicals may be considered as a functional food in reduced risk and treatment of autoimmune diseases. Intake of green tea extract should be taken with care as overdose-toxicity has been reported in a number of incidences.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(*) Epigallocatechin gallate inhibits oxidative stress-induced DNA damage and apoptosis in MRL-Fas(lpr) mice with autoimmune sialadenitis via upregulation of heme oxygenase-1 and Bcl-2. by Saito K1, Mori S, Date F, Ono M.(PubMed)
(*) EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1α with Th17/Treg control by Yang EJ1, Lee J2, Lee SY1, Kim EK1, Moon YM1, Jung YO3, Park SH2, Cho ML1.(PubMed)
(*) Green tea EGCG, T cells, and T cell-mediated autoimmune diseases by Wu D1, Wang J, Pae M, Meydani SN.(PubMed)
(*) The ability of green tea to alleviate autoimmune diseases: fact or fiction? by Wu D, Wang J.

#Antioxidants Found in Coffee Inhibit Parameters Associated with #InsulinResistance in Vivos, According to Studies

By Kyle J. Norton

Coffee intake daily and regularly may have a potential effect in improved insulin resistance, thus reducing the risk of early onset of diabetes, a university study proposed.

Insulin resistance is a condition characterized by a lowered level of insulin response to the level of glucose (sugar) in the body.

Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.


In a study of the effect of coffee against insulin resistance of Male C57BL/6N mice (N = 48) divided into six dietary groups: chow diet, HFD, HFD-supplemented with 0.1%, 0.3%, and 0.9% decaffeinated green coffee bean extract, researchers found that treatment of the minimum dose 0.3%. of green coffee bean extract showed a most significant effect in improved insulin levels caused by HFD- diet.

Furthermore, decaffeinated green coffee bean extract in the study also expressed reverse fat accumulation and insulin resistance caused by the HFD diet by downregulating the genes involved in adipogenesis and inflammation in fat tissues involved in insulin resistance.

Other, in the testing of bioactive substances in coffee in the expression of acutely and/or chronically increase insulin secretion from β-cells and improvement of insulin sensitivity in skeletal muscle cells, measurement of insulin secretion after Insulin secretion at acute (1-h) and long-term (72-h) incubation, the bioactive substances from coffee exerted the following results
1. A bioactive compound isolated from coffee at 10(-8) and 10(-6) M acutely increased insulin secretion by 12% and 16% respectively.
2. Long-term exposure to cafestol at 10(-10) and 10(-8) M increased insulin secretion by 34% and 68%,
respectively.
3. Caffeic acid, another compound isolated from coffee also increased insulin secretion acutely and chronically.
4. Compounds showed no association with insulin secretion, including Chlorogenic acid, trigonelline, oxokahweol, and secoisolariciresinol.

In support of the above analysis, the antidiabetic effects of coffee and caffeine on high-fat-diet-induced impaired glucose tolerance in C57BL/6J mice. C57BL/6J mice fed a high-fat diet given regular drinking water (control group), or a 2.5-fold-diluted coffee or caffeine solution (200 mg/L) for 17 weeks. indicated that the group treated with an injection of coffee caffeine strongly improve glucose tolerance, insulin sensitivity, and hyperinsulinemia compared with mice in the control group.

And coffee and caffeine exerted an ameliorative effect on high-fat-diet-induced impaired glucose tolerance through reduced inflammatory expression in genes and cytokines in improving insulin sensitivity.

Taking together, coffee may have the potential capability in reducing the risk of Insulin Resistance and early onset of diabetes through attenuated insulin resistance by bioactive compounds such as cafestol and caffeic acid.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Decaffeinated green coffee bean extract attenuates diet-induced obesity and insulin resistance in mice by Song SJ1, Choi S1, Park T1.(PubMed)
(2) Cafestol, a Bioactive Substance in Coffee, Stimulates Insulin Secretion and Increases Glucose Uptake in Muscle Cells: Studies in Vitro by Mellbye FB1, Jeppesen PB1, Hermansen K1, Gregersen S1.(PubMed)
(3) Coffee and caffeine improve insulin sensitivity and glucose tolerance in C57BL/6J mice fed a high-fat diet by Matsuda Y1, Kobayashi M, Yamauchi R, Ojika M, Hiramitsu M, Inoue T, Katagiri T, Murai A, Horio F.(PubMed)

#Antioxidant #Betaxanthins Block Chemical Reaction Against the Initiation of #ColonCancer Cells' Proliferation, According to Studies

By Kyle J. Norton

Primary cancer is a class of chronic disease caused by cells growing disorderly and irregularly in the tissue of a specific organ as a result of the alternation of DNA.

The colon formed part of the digestive system including the large intestine that connects to the small intestines and the rectum plays a critical role to reabsorb fluids and processing waste products from the body and prepare for their elimination through the rectum.

Colon cancer is a medical condition characterized by cell growth irregularly due to the alternation of DNA in the colon tissue.

Most cases of colon cancer start in the cell on the surface of the inner lining of the colon before penetrating into deeper layers to form a tumor through proliferation.

However, at the advanced stage, the cancerous colon cells in the colon can travel a distance far away to infect other healthy tissue and organ.

Furthermore, at this stage, the overgrowth can cause localized severe pain and bleeding as the proliferation of cancer have suppressed the nearby nerve cells and blood vessels, accompanied by the general symptoms shared by other types of cancer.

Researchers do not know the exact causes of the disease. A history of polyps, ethnicity, a high-fat diet and low fiber, aging, and long-term infection of colon diseases are some of the prevalent risk factors associated with the onset and progression of colon cancer.

Believe it or not, colon cancer is the most slowing cancer and proliferates in a predictable way. In some patients, cancer cells can present in the colon for more than 20 years before being diagnosed.

Out of that group of risk factors, the increase in age has been under intensified studies by many scientists.

According to the statistic, colorectal cancer is the third common cancer in the US. The median age at diagnosis for colon cancer is 68 in men and 72 in women.

In other words, most cases of colon cancer are found in the aging population in the US.

Early diagnosis of colon cancer can increase the 5 years of survival rate. Truly, in the 39% of colon cancer diagnosed at the localized-stage disease, the five and ten years survival rate are 90%.
Dr. and colleagues wrote, "Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. As society ages, the number of elderly patients with CRC will increase. The percentage of patients with right-sided colon cancer and the incidence of microsatellite instability is higher in elderly than in younger patients with CRC.".

And, "Moreover, the higher incidence of comorbid diseases in elderly patients indicates the need for less invasive treatment strategies".

These results furtherly confirm the prognosis of colon cancer in the aging population. However, most aging population do not develop colon cancer.

Betaxanthins are Phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.

With an aim to find a potent compound for the promotion of colon health, researchers examined the effects of indicaxanthin, a constituent of betaxanthins on the human colon cancer cell line CACO2.

In colon cancer lines induced demethylation, the chemical process that causes the removal of a methyl group (CH3) to initiate some methylation-silenced onco-suppressor genes involved in colorectal carcinogenesis, indicaxanthin exhibited anti-proliferative activity in all cell lines but HT29 and cancer cell line involved in hypermethylated tumor-suppressor genes(SFRP1 and HPP1).

Furthermore, although DNMT gene expression that provides instructions for making an enzyme called DNA methyltransferase 1 were increased by the injection of indicaxanthin, observed by the increased the expression of genes involved in DNA demethylation, its activity associated with gene suppression was inhibited by the phytochemical.

The results strongly suggested that indicaxanthin exerts a stable binding of the DNMT1 undergoing a chemical reaction against the initiation of colon cancer cell proliferation.

Taken altogether, Betaxanthins processed the abundantly indicaxanthin may be considered a remedy for the prevention and treatment of colon cancer, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phytochemical Indicaxanthin Inhibits Colon Cancer Cell Growth and Affects the DNA Methylation Status by Influencing Epigenetically Modifying Enzyme Expression and Activity by Naselli F1, Belshaw NJ, Gentile C, Tutone M, Tesoriere L, Livrea MA, Caradonna F. (PubMed)
(2) Treatment of Elderly Patients with Colorectal Cancer by Yoshiro Itatani, Kenji Kawada, and Yoshiharu Sakai. (PMC)