By Kyle J. Norton
Green tea phenolic content may have a sustainable and therapeutic effect in reducing the risk and progression of retinal degeneration, some scientists suggested.
Retinal degeneration is a macular disease characterized by impaired vision, night blindness, retinal detachment, light sensitivity, tunnel vision, and loss of peripheral vision to total loss of vision.
The evaluation of green tea's effect on the risk of retinal degeneration was found to be implicated by several mechanisms through a number of aspects.
In ROS implication of oxidative stress-induced degeneration of the retina occurred in age-related macular degeneration (AMD) and glaucoma, application of green tea polyphenols epigallocatechin gallate (EGCG) exhibited antioxidant effect as a free radical scavenger in the ameliorated chain reaction of ROS in causing loss of neuron with direct effects of retinal function and reduced cytotoxicity of free radicals in the induction of retinal cellular apoptosis.
Administration of green tea phenolic compound exerted 10 times more effective in the treatment of retinal degeneration, compared to potent medicine Trolox (vitamin E analog) in attenuating lipid peroxidation caused by the nitric oxide donor, sodium nitroprusside (SNP), according to the study.
Particularly, green tea epigallocatechin gallate (EGCG) inhibited a significant decrease in photoreceptor-specific markers (RET-P1, rhodopsin kinase) which may be an indication of photoreceptor cells in the transition to degenerate prematurely, eventually resulting in blindness and an increase in the cell death marker caspase-3 caused by oxidative stress induced by injection of sodium nitroprusside (SNP)
According to the observation by Western blotting techniques, SNP was completely inhibited by EGCG injection in ameliorating the detrimental effects to the retina caused by SNP.
Dr. Zhang B, the co-author said, "Since oxidative stress has been implicated in retinal diseases like AMD and glaucoma this study provides "proof of principle" for the idea that daily intake of EGCG may help individuals suffering from retinal diseases where oxidative stress is implicated".
More interestingly, in BALB/cJ mice treated with either EGCG or saline via intraperitoneal (IP) injection, and then placed under constant cool white light-emitting diode (LED) light (10,000 lux) for 5 h, the EGCG treatment group showed a strong protective effect on the retina against light damage (LD) in compared to the control group.
According to the optical coherence tomography (OCT) and electroretinography (ERG), the examine the retinal structure and function after LD indicated that the application of green tea EGCG improved significantly higher ERG amplitudes for all three wave types through inducing morphologic protection of photoreceptors also compared to control.
Moreover, the green tea extract bio-compound also decreased oxidative stress through increase the mRNA level of the antioxidant expression of Sod2, a manganese-dependent superoxide dismutase (MnSOD) before LD and 24 h after LD.
Dr. Qi S1,, the lead author said, "The IP injection of EGCG attenuated the detrimental effects of bright light on the retinas of BALB/cJ mice by protecting the structure and function of the retina".
Importantly, in study to evaluate green tea EGCG effect in reduced glutamate induced excitotoxicity in the retina, researchers conducted a study of female Wistar rats (n = 171) randomly signed into a normal control group (n = 9); saline control group with intravitreal saline injections (n = 54); NMDA control group with an intravitreal NMDA injection and intraperitoneal saline injections (n = 54); and NMDA study group (n = 54) receiving an intravitreal NMDA injection plus intraperitoneal EGCG (25 mg/kg) injections, observation of the groups at 2 weeks after additional injection of NMDA showed that group with treatment of intraperitoneal application of EGCG reduced a significantly less marked NMDA-associated loss of retinal ganglion cell, through inhibition of decreasing retinal ganglion cell layer (GCL), neurons located near the inner surface (the ganglion cell layer) of the retina of the eye in received visual information from photoreceptors via cell density and thickness of Thy-1 immunoreactivity in several areas of the immature and adult human brain in expression of retinal ganglion cell damage.
Taken together, there is no doubt that Epigallocatechin-3-gallate (EGCG), a major polyphenol of green tea, may be considered a secondary therapeutic treatment used a combination with standard therapy for the protection and treatment of retinal degenerative disease
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate by Zhang B1, Osborne NN(PubMed)
(2) Neuroprotective effect of epigallocatechin-3-gallate against N-methyl-D-aspartate-induced excitotoxicity in the adult rat retina by Chen F1, Jiang L, Shen C, Wan H, Xu L, Wang N, Jonas JB(PubMed)
(3) Intraperitoneal injection of (-)-Epigallocatechin-3-gallate protects against light-induced photoreceptor degeneration in the mouse retina by Qi S1,2, Wang C1,2, Song D2, Song Y2, Dunaief JL2.(PubMed)--
Thursday, 15 June 2023
#Phytochemical #Alliin Inhibits #Hypercholesterolemia by Reducing the Plasma Levels of Low-Density Lipoprotein, Researchers Say
By Kyle J. Norton
Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.
In other words, the condition is a result caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).
Cholesterol, a waxy substance produced by the liver or the dietary in moderate amount source plays a critical to aid digestive function in absorbing nutrients, building strong cell membranes, produce steroid hormones and vitamin D. However, excessive amounts in the blood have been found to induce plaque built-up on the arterial wall, leading to heart disease and stroke.
Similar to high blood pressure, people with hypercholesterolemia are asymptomatic. Patients with familial hyper cholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.
According to the statistics provided by the CDC, hypercholesterolemia is a major risk factor for heart disease, a leading cause of death in the US. In the US, approximately, 71 million American adults (33.5%) have high low-density lipoprotein (LDL), or “bad,” cholesterol. and only 1 out of every 3 adults with high LDL cholesterol has the condition under control.
Sadly, only 50% of people with hypercholesterolemia are getting treatment.
Out of many risk factors associated with the risk of hypercholesterolemia, some researchers suggested that the widespread obesity due to the promotion of a high-fat diet over the past few decades may have a strong impact on the increased incidence in the US.
Dr. Jeannie Chan, the lead scientist wrote, "ApoE deficient mice, generated by gene targeting, have a lipoprotein profile similar to humans in that most of the plasma cholesterol is carried on VLDL and IDL particles rather than HDL particles as in non-genetically modified mice. ApoE-/- mice have elevated levels of plasma cholesterol even on a chow diet and develop atherosclerotic lesions spontaneously. Advanced lesions with plaque rupture that resemble those in humans have frequently been observed in apoE-/- mice fed an HCHF diet, and these mice are used for developing drugs to reduce atherosclerosis".
In other words, a high-fat diet promoted the genes associated with cholesterol secretion.
With an aim to find a potential ingredient for the treatment of hypercholesterolemia, researchers evaluated the capacity of Allium ursinum (wild garlic) leaf lyophilisate (WGLL; alliin content: 0.261%) to mitigate cardiovascular damage in hypercholesterolemic rabbits.
New Zealand rabbits selected for the study were divided into three groups: (i) cholesterol-free rabbit chow (control); (ii) rabbit chow containing 2% cholesterol (hypercholesterolemic, HC); (iii) rabbit chow containing 2% cholesterol + 2% WGLL (hypercholesterolemic treated, HCT); for eight weeks.
According to the Western blot analysis, WGLL protected the heart by improving aortic and coronary flow.
WGLL was also found to inhibit atherosclerotic plaque coverage.
Furthermore, WGLL also reduced the risk of hypercholesteremia by significantly reducing the plasma levels of low-density lipoprotein.
Based on the findings, researchers said, "The results clearly demonstrate that WGLL has complex cardioprotective effects, suggesting future strategies for its use in prevention and therapy for atherosclerotic disorders".
Taken altogether, alliin may be considered a supplement for the prevention and treatment of heart disease associated with hypercholesterolemia, depending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits by Bombicz M1,2, Priksz D3,4, Varga B5,6, Gesztelyi R7, Kertesz A8, Lengyel P9, Balogh P10, Csupor D11, Hohmann J12, Bhattoa HP13, Haines DD14, Juhasz B. (PubMed)
(2) Effect of garlic on lipid profile and psychopathologic parameters in people with mild to moderate hypercholesterolemia by Peleg A1, Hershcovici T, Lipa R, Anbar R, Redler M, Beigel Y. (PubMed)
(3) Animal Models of Diet-induced Hypercholesterolemia By Jeannie Chan, Genesio M. Karere, Laura A. Cox and John L. VandeBerg.
Hypercholesterolemia is a condition characterized by abnormally high levels of cholesterol in the bloodstream.
In other words, the condition is a result caused by either overexpression of low-density lipoprotein (LDL) or low levels of high-density lipoprotein (HDL).
Cholesterol, a waxy substance produced by the liver or the dietary in moderate amount source plays a critical to aid digestive function in absorbing nutrients, building strong cell membranes, produce steroid hormones and vitamin D. However, excessive amounts in the blood have been found to induce plaque built-up on the arterial wall, leading to heart disease and stroke.
Similar to high blood pressure, people with hypercholesterolemia are asymptomatic. Patients with familial hyper cholesterol may experience symptoms of chest pain with activity. xanthomas, and cholesterol deposits around the eyelids.
According to the statistics provided by the CDC, hypercholesterolemia is a major risk factor for heart disease, a leading cause of death in the US. In the US, approximately, 71 million American adults (33.5%) have high low-density lipoprotein (LDL), or “bad,” cholesterol. and only 1 out of every 3 adults with high LDL cholesterol has the condition under control.
Sadly, only 50% of people with hypercholesterolemia are getting treatment.
Out of many risk factors associated with the risk of hypercholesterolemia, some researchers suggested that the widespread obesity due to the promotion of a high-fat diet over the past few decades may have a strong impact on the increased incidence in the US.
Dr. Jeannie Chan, the lead scientist wrote, "ApoE deficient mice, generated by gene targeting, have a lipoprotein profile similar to humans in that most of the plasma cholesterol is carried on VLDL and IDL particles rather than HDL particles as in non-genetically modified mice. ApoE-/- mice have elevated levels of plasma cholesterol even on a chow diet and develop atherosclerotic lesions spontaneously. Advanced lesions with plaque rupture that resemble those in humans have frequently been observed in apoE-/- mice fed an HCHF diet, and these mice are used for developing drugs to reduce atherosclerosis".
In other words, a high-fat diet promoted the genes associated with cholesterol secretion.
With an aim to find a potential ingredient for the treatment of hypercholesterolemia, researchers evaluated the capacity of Allium ursinum (wild garlic) leaf lyophilisate (WGLL; alliin content: 0.261%) to mitigate cardiovascular damage in hypercholesterolemic rabbits.
New Zealand rabbits selected for the study were divided into three groups: (i) cholesterol-free rabbit chow (control); (ii) rabbit chow containing 2% cholesterol (hypercholesterolemic, HC); (iii) rabbit chow containing 2% cholesterol + 2% WGLL (hypercholesterolemic treated, HCT); for eight weeks.
According to the Western blot analysis, WGLL protected the heart by improving aortic and coronary flow.
WGLL was also found to inhibit atherosclerotic plaque coverage.
Furthermore, WGLL also reduced the risk of hypercholesteremia by significantly reducing the plasma levels of low-density lipoprotein.
Based on the findings, researchers said, "The results clearly demonstrate that WGLL has complex cardioprotective effects, suggesting future strategies for its use in prevention and therapy for atherosclerotic disorders".
Taken altogether, alliin may be considered a supplement for the prevention and treatment of heart disease associated with hypercholesterolemia, depending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits by Bombicz M1,2, Priksz D3,4, Varga B5,6, Gesztelyi R7, Kertesz A8, Lengyel P9, Balogh P10, Csupor D11, Hohmann J12, Bhattoa HP13, Haines DD14, Juhasz B. (PubMed)
(2) Effect of garlic on lipid profile and psychopathologic parameters in people with mild to moderate hypercholesterolemia by Peleg A1, Hershcovici T, Lipa R, Anbar R, Redler M, Beigel Y. (PubMed)
(3) Animal Models of Diet-induced Hypercholesterolemia By Jeannie Chan, Genesio M. Karere, Laura A. Cox and John L. VandeBerg.
#Phytochemical #Alliin Inhibits #LiverCells DNA Damage That Cause #LiverCancer in Vivos, According to Studies
By Kyle J. Norton
The liver is the largest detoxed internal organ with a function to filter out blood coming from the intestines before passing them to other parts of the body,
Additionally, the liver also produces cholesterol to aid digestion, the production of steroid hormones, vitamin D, and the building of strong cell membranes.
Liver cancer is a chronic condition caused by irregular cell growth due to the alternation of liver cell DNA.
Compared to average liver cell growth which is stopped after a certain stage of division, liver cancer cells can grow indefinitely to form a tumor, leading to reduced function of the liver.
According to the statistics provided by the American Cancer Society, in 2019, about 42,030 new cases (29,480 in men and 12,550 in women) will be diagnosed.
Primary liver cancer and intrahepatic bile duct cancer also cause the death of 31,780 people (21,600 men and 10,180 women) in 2019.
In the Western world, non-alcoholic fatty liver disease(NAFLD), a spectrum of hepatic disorders induced by obesity and metabolic syndrome, is a recognized risk factor for liver cancer.
Dr. György Baffy at the Harvard Medical School wrote, "Hepatocellular cancer (HCC) is the fifth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. Non-alcoholic fatty liver disease (NAFLD), a spectrum of hepatic disorders associated with obesity and metabolic syndrome, is a recognized risk factor for HCC".
And, "NAFLD that is advanced to cirrhosis carries the highest risk for HCC, but there is an increasing concern that NAFLD-associated HCC may also occur in the non-cirrhotic liver".
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential compound for the treatment of liver cancer, researchers examined the bioactive compound alliin isolated from garlic in an animal model, against liver cell DNA damage.
The study included rats induced liver cancer by N-nitroso dimethylamine (NDMA) treated with garlic powders for 2 weeks (5% of the diet).
According to the liver comet assay, injection of different garlic powders demonstrated a significant liver protective effect by a 35-60% reduction in DNA damage induced by N-nitroso dimethylamine (NDMA) in rat liver.
Additional injection of alliin content of the garlic powder showed a strongly proportional decrease in NDMA-induced DNA alteration.
Three garlic powders with or without alliin also protected the liver cell against DNA damage induced by aflatoxin B1 in the liver.
However, these decreases were not correlated to the allicin content of the garlic powders.
In other words, additional alliin increased the garlic powder function in the inhibition of liver cancer initiation caused by NDMA while alliin found in the garlic must work with other compounds synergically to induce the same effects.
Taken altogether, alliin may be considered supplements for the prevention and treatment of liver cancer, pending confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content by Singh V1, Belloir C, Siess MH, Le Bon AM. (PubMed)
(2) Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: Epidemiology, Pathogenesis, and Prevention by György Baffy. (PMC)
The liver is the largest detoxed internal organ with a function to filter out blood coming from the intestines before passing them to other parts of the body,
Additionally, the liver also produces cholesterol to aid digestion, the production of steroid hormones, vitamin D, and the building of strong cell membranes.
Liver cancer is a chronic condition caused by irregular cell growth due to the alternation of liver cell DNA.
Compared to average liver cell growth which is stopped after a certain stage of division, liver cancer cells can grow indefinitely to form a tumor, leading to reduced function of the liver.
According to the statistics provided by the American Cancer Society, in 2019, about 42,030 new cases (29,480 in men and 12,550 in women) will be diagnosed.
Primary liver cancer and intrahepatic bile duct cancer also cause the death of 31,780 people (21,600 men and 10,180 women) in 2019.
In the Western world, non-alcoholic fatty liver disease(NAFLD), a spectrum of hepatic disorders induced by obesity and metabolic syndrome, is a recognized risk factor for liver cancer.
Dr. György Baffy at the Harvard Medical School wrote, "Hepatocellular cancer (HCC) is the fifth most prevalent cancer worldwide and the third leading cause of cancer-related deaths. Non-alcoholic fatty liver disease (NAFLD), a spectrum of hepatic disorders associated with obesity and metabolic syndrome, is a recognized risk factor for HCC".
And, "NAFLD that is advanced to cirrhosis carries the highest risk for HCC, but there is an increasing concern that NAFLD-associated HCC may also occur in the non-cirrhotic liver".
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential compound for the treatment of liver cancer, researchers examined the bioactive compound alliin isolated from garlic in an animal model, against liver cell DNA damage.
The study included rats induced liver cancer by N-nitroso dimethylamine (NDMA) treated with garlic powders for 2 weeks (5% of the diet).
According to the liver comet assay, injection of different garlic powders demonstrated a significant liver protective effect by a 35-60% reduction in DNA damage induced by N-nitroso dimethylamine (NDMA) in rat liver.
Additional injection of alliin content of the garlic powder showed a strongly proportional decrease in NDMA-induced DNA alteration.
Three garlic powders with or without alliin also protected the liver cell against DNA damage induced by aflatoxin B1 in the liver.
However, these decreases were not correlated to the allicin content of the garlic powders.
In other words, additional alliin increased the garlic powder function in the inhibition of liver cancer initiation caused by NDMA while alliin found in the garlic must work with other compounds synergically to induce the same effects.
Taken altogether, alliin may be considered supplements for the prevention and treatment of liver cancer, pending confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content by Singh V1, Belloir C, Siess MH, Le Bon AM. (PubMed)
(2) Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: Epidemiology, Pathogenesis, and Prevention by György Baffy. (PMC)
#Yoga Improves Quality of Life of #Parkinson's Disease Patients, Researchers Say
By Kyle J. Norton
People who participated in yoga classes have a profound and positive impact in reducing symptoms of Parkinson's disease, a renowned study suggested.
Yoga, the accident technique practice for harmonized external and internal body well-being, through breath control, meditation, bodily movement, and gesture..... has been well known for people in the Western world and some parts of Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.
Parkinson's disease is a condition that affected motor and nonmotor functions and causes severe debility and poor quality of life, a recent study suggested.
According to statistics, approximately one million are living with Parkinson's disease (PD) in the U.S.
Every year, over 60,000 Americans are diagnosed with PD.
And, if you are men, you are 1.5 times more likely to have Parkinson's disease compared to women.
In the discussion with 28 experienced yoga experts, who fulfilled the inclusion criteria, and selected validating the content of the integrated yoga module(IYM) for PD, researchers found that 21 out of 28 exhibited significant content validity by applying Lawshe's formula for the content validity ratio (CVR) of 0.42.
Additionally, a randomized controlled pilot study investigated the effectiveness of yoga intervention on physiological and health-related QOL measures in people with PD with 13 people with stage 1-2 PD randomized to either a yoga (n = 8) or a control group (n = 5) and the yoga group participated in twice-weekly yoga sessions for 12 weeks, searchers found that yoga participants demonstrate a significant improvement in Unified Parkinson's Disease Rating Scale (UPDRS)scores, improved diastolic blood pressure (P = 0.036) and average forced vital capacity (P = 0.03) over time, in compared to control.
Furthermore, researchers also indicated that the yoga group expressed positive trends of improvement in depression scores (P = 0.056), body weight (P = 0.056), and forced expiratory volume (P = 0.059).
More profoundly, Yoga participants reported more positive symptom changes including immediate tremor reduction compared to the control group. Collectively, yoga significantly improves aspects of QOL and physiological functions in stages 1-2 PD patients.
Importantly, in support of the above differentiation, the California State University, in measuring the effect of an eight-week adaptive yoga program on the physical and psychological status of individuals with Parkinson's disease pilot study suggested, after assessing the result of 10 participants with a Hoehn and Yahr stage of 2 or 3 prior to and after an 8-week control phase and again after they underwent an 8-week adaptive yoga program scientists suggested that yoga participants not only reduced expression of depression, anxiety in both genders but also enhanced sit-and-reach flexibility in male participants in compared to female counterparts.
In younger participants, yoga showed an enormous improvement in the Single-Leg Balance test(SLB) time after the intervention.
Indeed, in the compare the effects of power training (PWT) and a high-speed yoga program on physical performances in older patients with Parkinson's disease (PD), researchers indicated that both yoga programs and PWT programs can significantly improve physical performance in older persons with PD.
In other words, Dr. Ni M, the leading author said, "Both training groups showed significant improvements (P<.05) in all physical measurements except functional reach on the more affected side, SLS, and postural sway compared with the pretests, and significantly better scores for UPDRSMS, BBS, Mini-BESTest, Timed Up and Go, functional reach on the less affected side".
Taking it all together, yoga no doubt has a fabulous effect in improving both physical and psychological symptoms in the early stage of Parkinson's disease. Some researchers even suggested that yoga may be used as an integrated form of exercise conventionally with conventional therapy.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Development and validation of a yoga module for Parkinson's disease by Kakde N1, Metri KG1, Varambally S1, Nagaratna R1, Nagendra HR1.(PubMed)
(2) Comparative Effect of Power Training and High-Speed Yoga on Motor Function in Older Patients With Parkinson's Disease by Ni M1, Signorile JF2, Mooney K3, Balachandran A1, Potiaumpai M1, Luca C4, Moore JG5, Kuenze CM1, Eltoukhy M1, Perry AC1.(PubMed)
(3) A randomized controlled pilot study of the therapeutic effects of yoga in people with Parkinson's disease by Sharma NK1, Robbins K1, Wagner K1, Colgrove YM1.(PubMed)
(3) Measuring the effect of an eight-week adaptive yoga program on the physical and psychological status of individuals with Parkinson's disease. A pilot study by Boulgarides LK1, Barakatt E, Coleman-Salgado B.(PubMed)
(4) Controlled pilot study of the effects of power yoga in Parkinson's disease by Ni M1, Mooney K2, Signorile JF3.(PubMed)
People who participated in yoga classes have a profound and positive impact in reducing symptoms of Parkinson's disease, a renowned study suggested.
Yoga, the accident technique practice for harmonized external and internal body well-being, through breath control, meditation, bodily movement, and gesture..... has been well known for people in the Western world and some parts of Asia due to health benefits reported by various respectable institutes' research and supported by health advocates.
Parkinson's disease is a condition that affected motor and nonmotor functions and causes severe debility and poor quality of life, a recent study suggested.
According to statistics, approximately one million are living with Parkinson's disease (PD) in the U.S.
Every year, over 60,000 Americans are diagnosed with PD.
And, if you are men, you are 1.5 times more likely to have Parkinson's disease compared to women.
In the discussion with 28 experienced yoga experts, who fulfilled the inclusion criteria, and selected validating the content of the integrated yoga module(IYM) for PD, researchers found that 21 out of 28 exhibited significant content validity by applying Lawshe's formula for the content validity ratio (CVR) of 0.42.
Additionally, a randomized controlled pilot study investigated the effectiveness of yoga intervention on physiological and health-related QOL measures in people with PD with 13 people with stage 1-2 PD randomized to either a yoga (n = 8) or a control group (n = 5) and the yoga group participated in twice-weekly yoga sessions for 12 weeks, searchers found that yoga participants demonstrate a significant improvement in Unified Parkinson's Disease Rating Scale (UPDRS)scores, improved diastolic blood pressure (P = 0.036) and average forced vital capacity (P = 0.03) over time, in compared to control.
Furthermore, researchers also indicated that the yoga group expressed positive trends of improvement in depression scores (P = 0.056), body weight (P = 0.056), and forced expiratory volume (P = 0.059).
More profoundly, Yoga participants reported more positive symptom changes including immediate tremor reduction compared to the control group. Collectively, yoga significantly improves aspects of QOL and physiological functions in stages 1-2 PD patients.
Importantly, in support of the above differentiation, the California State University, in measuring the effect of an eight-week adaptive yoga program on the physical and psychological status of individuals with Parkinson's disease pilot study suggested, after assessing the result of 10 participants with a Hoehn and Yahr stage of 2 or 3 prior to and after an 8-week control phase and again after they underwent an 8-week adaptive yoga program scientists suggested that yoga participants not only reduced expression of depression, anxiety in both genders but also enhanced sit-and-reach flexibility in male participants in compared to female counterparts.
In younger participants, yoga showed an enormous improvement in the Single-Leg Balance test(SLB) time after the intervention.
Indeed, in the compare the effects of power training (PWT) and a high-speed yoga program on physical performances in older patients with Parkinson's disease (PD), researchers indicated that both yoga programs and PWT programs can significantly improve physical performance in older persons with PD.
In other words, Dr. Ni M, the leading author said, "Both training groups showed significant improvements (P<.05) in all physical measurements except functional reach on the more affected side, SLS, and postural sway compared with the pretests, and significantly better scores for UPDRSMS, BBS, Mini-BESTest, Timed Up and Go, functional reach on the less affected side".
Taking it all together, yoga no doubt has a fabulous effect in improving both physical and psychological symptoms in the early stage of Parkinson's disease. Some researchers even suggested that yoga may be used as an integrated form of exercise conventionally with conventional therapy.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Development and validation of a yoga module for Parkinson's disease by Kakde N1, Metri KG1, Varambally S1, Nagaratna R1, Nagendra HR1.(PubMed)
(2) Comparative Effect of Power Training and High-Speed Yoga on Motor Function in Older Patients With Parkinson's Disease by Ni M1, Signorile JF2, Mooney K3, Balachandran A1, Potiaumpai M1, Luca C4, Moore JG5, Kuenze CM1, Eltoukhy M1, Perry AC1.(PubMed)
(3) A randomized controlled pilot study of the therapeutic effects of yoga in people with Parkinson's disease by Sharma NK1, Robbins K1, Wagner K1, Colgrove YM1.(PubMed)
(3) Measuring the effect of an eight-week adaptive yoga program on the physical and psychological status of individuals with Parkinson's disease. A pilot study by Boulgarides LK1, Barakatt E, Coleman-Salgado B.(PubMed)
(4) Controlled pilot study of the effects of power yoga in Parkinson's disease by Ni M1, Mooney K2, Signorile JF3.(PubMed)
#ModeratedCoffee Intake Is Associated with a Reduced Risk of #HeartFailure, According to Studies
By Kyle J. Norton
A renowned university study suggested that intake of coffee and coffee caffeine daily and regularly is associated with a reduced risk of heart failure.
Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.
In the review literature from the electronic databases (MEDLINE, Embase, and CINAHL) from January 1966 through December 2011, including five independent prospective studies of coffee consumption and heart failure risk, including 6522 heart failure events and 140 220 participants satisfied the standardized protocol, researchers found that coffee consumption displayed a statistically significant J-shaped relationship between coffee and heart failure.
The most effective serving of coffee in reducing the risk of heart failure incidence was 4 servings/day.
but the risk of heart failure increased substantially for people drinking more than 4 cups daily and regularly.
Furthermore, other factors such as sex or by baseline history of myocardial infarction or diabetes showed an insignificant risk of heart failure developing.
Dr. Mostofsky E, the lead author said, "Moderate coffee consumption is inversely associated with risk of heart failure, with the largest inverse association observed for consumption of 4 servings per day".
Additionally, cohorts studies included 59,490 Finnish participants aged 25-74 years, free of HF at baseline, and risk of HF associated with the amount of coffee consumption daily (0, 1-2, 3-4, 5-6, 7-9 and ≥10 cups) were 1.00, 0.9, 0.88, 0.91, 0.96 and 1.02 for men and 1.00, 0.73, 0.77, 0.68, 0.80 and 0.88 for women, respectively.
The result indicated a strong correlation between coffee intake daily and regular in the ameliorated risk of heart failure in women, and coffee consumption was not associated to increase the risk of HF in men. regardless of other independent factors such as age, smoking status, alcohol consumption, history of type 2 diabetes mellitus, and body mass index.
Promisingly, according to the meta-analyses of recent well-controlled prospective epidemiologic studies, conducted by the National University of Singapore and the National University Health System, coffee consumption is associated with a lower risk of heart failure, and for most healthy people, moderate coffee consumption is unlikely to adversely affect cardiovascular health.
Taking all together, Moderated intake of coffee may have a profound effect on the attenuated risk of heart failure, particularly in women, after taking into account other factors.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Habitual coffee consumption and risk of heart failure: a dose-response meta-analysis by Mostofsky E1, Rice MS, Levitan EB, Mittleman MA.(PubMed)
(2) Coffee consumption and the risk of heart failure in Finnish men and women by Wang Y1, Tuomilehto J, Jousilahti P, Antikainen R, Mähönen M, Männistö S, Katzmarzyk PT, Hu G.(PubMed)
(3) Coffee consumption and cardiovascular health: getting to the Heart of the Matter by Rebello SA1, van Dam RM.(PubMed)
A renowned university study suggested that intake of coffee and coffee caffeine daily and regularly is associated with a reduced risk of heart failure.
Coffee, a popular and social beverage all over the world, particularly in the West, is a drink made from roasted beans from the Coffea plant, native to tropical Africa and Madagascar.
In the review literature from the electronic databases (MEDLINE, Embase, and CINAHL) from January 1966 through December 2011, including five independent prospective studies of coffee consumption and heart failure risk, including 6522 heart failure events and 140 220 participants satisfied the standardized protocol, researchers found that coffee consumption displayed a statistically significant J-shaped relationship between coffee and heart failure.
The most effective serving of coffee in reducing the risk of heart failure incidence was 4 servings/day.
but the risk of heart failure increased substantially for people drinking more than 4 cups daily and regularly.
Furthermore, other factors such as sex or by baseline history of myocardial infarction or diabetes showed an insignificant risk of heart failure developing.
Dr. Mostofsky E, the lead author said, "Moderate coffee consumption is inversely associated with risk of heart failure, with the largest inverse association observed for consumption of 4 servings per day".
Additionally, cohorts studies included 59,490 Finnish participants aged 25-74 years, free of HF at baseline, and risk of HF associated with the amount of coffee consumption daily (0, 1-2, 3-4, 5-6, 7-9 and ≥10 cups) were 1.00, 0.9, 0.88, 0.91, 0.96 and 1.02 for men and 1.00, 0.73, 0.77, 0.68, 0.80 and 0.88 for women, respectively.
The result indicated a strong correlation between coffee intake daily and regular in the ameliorated risk of heart failure in women, and coffee consumption was not associated to increase the risk of HF in men. regardless of other independent factors such as age, smoking status, alcohol consumption, history of type 2 diabetes mellitus, and body mass index.
Promisingly, according to the meta-analyses of recent well-controlled prospective epidemiologic studies, conducted by the National University of Singapore and the National University Health System, coffee consumption is associated with a lower risk of heart failure, and for most healthy people, moderate coffee consumption is unlikely to adversely affect cardiovascular health.
Taking all together, Moderated intake of coffee may have a profound effect on the attenuated risk of heart failure, particularly in women, after taking into account other factors.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Habitual coffee consumption and risk of heart failure: a dose-response meta-analysis by Mostofsky E1, Rice MS, Levitan EB, Mittleman MA.(PubMed)
(2) Coffee consumption and the risk of heart failure in Finnish men and women by Wang Y1, Tuomilehto J, Jousilahti P, Antikainen R, Mähönen M, Männistö S, Katzmarzyk PT, Hu G.(PubMed)
(3) Coffee consumption and cardiovascular health: getting to the Heart of the Matter by Rebello SA1, van Dam RM.(PubMed)
#Herbal #AshwagandhaExtract Inhibits all Parameteras Associated with #Aging Progression, According to Studies
By Kyle J. Norton
Aging is a natural process of getting older. Antiaging is a term that refers to slowing down the aging process. In other words, anti-aging is an action that makes your appearance that looks younger than your biological age, inclduing the use of herbal medicine.
What causes aging? The question that has been asked throughout human history. While many theories try to answer the question by relating aging to the tears and wear of the body, others deal with how the organs and systems in the body develop and deteriorate over time, etc.
The antioxidant theory suggested that the accumulation of damage due to oxidative stress over the long term can initiate DNA oxidation, leading to DNA methylation.
In hormonal theory, the decrease in hormone production gradually found in the human body may contribute to a major cause of aging progression.
In other words, reduced production of hormones affects the amount of hormone released into the bloodstream, leading to decreased functioning of the target organs and systems.
The somatic mutation theory even suggested aging is due to the inherited genes that come directly from the parents. Lifelong exposures to toxins, radiation or ultraviolet light, artificial ingredients, and an unhealthy lifestyle, can increase the risk of cell mutation, leading to incorrect DNA coping.
Some researchers suggested that improved nutrient intake may have a strong effect in delaying the progression of aging and reducing the risk of age-related diseases.
Dr. D. Marsman and colleagues wrote, "New clinical studies of healthy aging are needed and quantitative biomarkers are an essential component, particularly tools which can measure improvements in physiological integrity throughout life, thought to be a primary contributor to a long and productive life (a healthy “lifespan”).
And, "A framework for progress has recently been proposed in a WHO report which takes a broad, person-centered focus on healthy aging, emphasizing the need to better understand an individual’s intrinsic capacity, their functional abilities at various life stages, and the impact by mental, and physical health, and the environments they inhabit.".
The results strongly suggested that if you follow a healthy diet with plenty of nutrients by focusing on calories, and macronutrients, you may delay the process of biological aging.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In finding a potent anti-aging compound, researchers examined the effects of Ashwagandha ( Withania somnifera) in the promotion of youthful vigor, including fatigue, vigor, and steroid hormones in aging men.
The randomized, double-blind, placebo-controlled, crossover study included overweight men aged 40-70 years, with mild fatigue given a placebo or an ashwagandha extract (Shoden beads, delivering 21 mg of withanolide glycosides a day) for 8 weeks.
According to the tested analysis of 50 people completing the first 8-week period of the trial and 43 completing all 16 weeks, the ashwagandha extract-treated group showed improvements in fatigue, vigor, and sexual and psychological well-being.
Furthermore, Ashwagandha intake demonstrated an 18% greater increase in DHEA-S and a 14.7% greater increase in testosterone, compared to the placebo without affecting levels of cortisol and estradiol.
In other words, Ashwagandha increased the levels of male hormones compared to the placebo.
Based on the finding, researchers concluded, " the intake of a standardized ashwagandha extract (Shoden beads) for 8 weeks was associated with increased levels of DHEA-S and testosterone, although no significant between-group differences were found in cortisol, estradiol, fatigue, vigor, or sexual well-being".
Taken altogether, Ashwagandha may be used as an anti-aging functional herb, pending the results from the large sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males by Lopresti AL1,2, Drummond PD1, Smith SJ. (PubMed)
(2) Healthy aging: the natural consequences of good nutrition—a conference report by D. Marsman,1 D. W. Belsky,2 D. Gregori,3 M. A. Johnson,4 T. Low Dog,5 S. Meydani,6S. Pigat,7 R. Sadana,8 A. Shao,9 and J. C. Griffiths. (PMC)
Aging is a natural process of getting older. Antiaging is a term that refers to slowing down the aging process. In other words, anti-aging is an action that makes your appearance that looks younger than your biological age, inclduing the use of herbal medicine.
What causes aging? The question that has been asked throughout human history. While many theories try to answer the question by relating aging to the tears and wear of the body, others deal with how the organs and systems in the body develop and deteriorate over time, etc.
The antioxidant theory suggested that the accumulation of damage due to oxidative stress over the long term can initiate DNA oxidation, leading to DNA methylation.
In hormonal theory, the decrease in hormone production gradually found in the human body may contribute to a major cause of aging progression.
In other words, reduced production of hormones affects the amount of hormone released into the bloodstream, leading to decreased functioning of the target organs and systems.
The somatic mutation theory even suggested aging is due to the inherited genes that come directly from the parents. Lifelong exposures to toxins, radiation or ultraviolet light, artificial ingredients, and an unhealthy lifestyle, can increase the risk of cell mutation, leading to incorrect DNA coping.
Some researchers suggested that improved nutrient intake may have a strong effect in delaying the progression of aging and reducing the risk of age-related diseases.
Dr. D. Marsman and colleagues wrote, "New clinical studies of healthy aging are needed and quantitative biomarkers are an essential component, particularly tools which can measure improvements in physiological integrity throughout life, thought to be a primary contributor to a long and productive life (a healthy “lifespan”).
And, "A framework for progress has recently been proposed in a WHO report which takes a broad, person-centered focus on healthy aging, emphasizing the need to better understand an individual’s intrinsic capacity, their functional abilities at various life stages, and the impact by mental, and physical health, and the environments they inhabit.".
The results strongly suggested that if you follow a healthy diet with plenty of nutrients by focusing on calories, and macronutrients, you may delay the process of biological aging.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In finding a potent anti-aging compound, researchers examined the effects of Ashwagandha ( Withania somnifera) in the promotion of youthful vigor, including fatigue, vigor, and steroid hormones in aging men.
The randomized, double-blind, placebo-controlled, crossover study included overweight men aged 40-70 years, with mild fatigue given a placebo or an ashwagandha extract (Shoden beads, delivering 21 mg of withanolide glycosides a day) for 8 weeks.
According to the tested analysis of 50 people completing the first 8-week period of the trial and 43 completing all 16 weeks, the ashwagandha extract-treated group showed improvements in fatigue, vigor, and sexual and psychological well-being.
Furthermore, Ashwagandha intake demonstrated an 18% greater increase in DHEA-S and a 14.7% greater increase in testosterone, compared to the placebo without affecting levels of cortisol and estradiol.
In other words, Ashwagandha increased the levels of male hormones compared to the placebo.
Based on the finding, researchers concluded, " the intake of a standardized ashwagandha extract (Shoden beads) for 8 weeks was associated with increased levels of DHEA-S and testosterone, although no significant between-group differences were found in cortisol, estradiol, fatigue, vigor, or sexual well-being".
Taken altogether, Ashwagandha may be used as an anti-aging functional herb, pending the results from the large sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha ( Withania somnifera) in Aging, Overweight Males by Lopresti AL1,2, Drummond PD1, Smith SJ. (PubMed)
(2) Healthy aging: the natural consequences of good nutrition—a conference report by D. Marsman,1 D. W. Belsky,2 D. Gregori,3 M. A. Johnson,4 T. Low Dog,5 S. Meydani,6S. Pigat,7 R. Sadana,8 A. Shao,9 and J. C. Griffiths. (PMC)
#GreenTea's #EGCG, Inhibits Oxidativestress and Acts as #IronChelator Against the Risk of #Parkinson's disease, Researchers Suggest
By Kye J. Norton
Green tea may be considered as a functional food and iron chelator in reduced risk and progression of Parkinson's disease, some scientists suggested
Iron chelation therapy is a primary and standard treatment for patients with iron overload.
Green tea is a precious drink that processes a number of health benefits known to almost everyone in Asia and the Western world.
Parkinson's disease (PD) is a progressive neurodegenerative disease, that causes severe depletion of glutamatergic and dopaminergic inputs in the striatum.
\
Investigation of the green tea EGCG effect in risk and progression of PD has been found to associate to many mechanisms involved in a number of aspects.
Application of metal chelation was found to ameliorate the expression of ROS in the induction of oxidative stress through a chain of reaction and precipitation of aggregation of alpha-synuclein and beta-amyloid peptides deposit in the brain, main leading causes to the onset of PD.
In iron abnormality PD subjects, oxidopamine, also known as 6-hydroxydopamine or 2,4,5-trihydroxyphenethylamine(6-OHD), a neurotoxic synthetic organic compound was found to disrupt iron metabolism, leading to overexpression of the iron induction of dyshomeostasis cause of iron toxicity and oxidative damage in dopaminergic neurons.
Green tea major polyphenol, (−)-epigallocatechin-3-gallate used in metal chelation, ameliorated iron-dependent free radicals located in the subcellular compartments and cellular membranes, through the effect in inhibited iron input and exhibited iron output in brain areas where it preferentially accumulates in neurodegenerative diseases, particularly Parkinsons' disease.
Further analysis of the neurotoxin 6-OHDA causes of iron unstable equilibrium, green extract GECG administration improved the function of hepcidin, a liver-derived hormone in regulated iron dyshomeostasis and gene expression of the iron metabolism through expressions of iron regulatory proteins (IRP1 and IRP2) in regulated the RNA level, between the transcription and the translation of the gene in expression of the iron homeostasis.
Indeed, In the differentiation of neurotoxin 6-OHDA induced iron dyshomeostasis has shown to increase oxidative stress in damage to neuron cells, green extract GECG effects demonstrated a significant inhibition of free radical and iron-free radical expression in the cellular membranes through the antioxidant activities and anti-inflammatory system and expression of nuclear factor-like 2(Nrf2) in stimulated production of antioxidant in protection against oxidative damage during injury and inflammation; heme oxygenase-1(HO-1) in increased production of superoxide dismutase and catalase against ROS and peroxisome proliferator-activated receptor-gamma (PPARγ) in regulated production of pro and anti-inflammatory cytokines and cytokines..
By reducing the overexpression of oxidative damage to neuron cells through regulation of iron-related factors as mentioned above, iron chelator EGCG can counteract these adverse effects and prevent the onset of PD.
Further study of the mechanism on disruption of iron metabolism by 6-OHDA in PD cell line N27, discovered that application of the iron chelator EGCG also disrupts the iron dyshomeostasis in N27 cells (dopaminergic neural cell line) induced by 6-OHDA through regulating iron transporters and regulators expression, such as DMT1 with function in mediation of the entry of dietary iron into these mucosal cells and TfR, a carrier protein for transferrin with function in import iron into the cell and regulated response to intracellular iron concentration and hepcidin, a central regulator in maintain iron homeostasis.
Dysregulation of hepcidin production results in a variety of iron disorders.
Additionally, in 6-OHDA induced neurotoxicity to cause PD, administration of green tea GECG also reduced the intracellular iron retention by decreasing the iron importers and increasing iron exporters, through regulation of the function of iron-regulated transporters, such as ferroportin.
Interestingly, there was a report suggested that the intervention of 3 cups of green tea daily for 3 months improved the antioxidant status and reduced oxidative damage in early PD patients without affecting their iron status.
The findings revealed that green tea bioactive polyphenol, (−)-epigallocatechin-3-gallate may be considered as an iron chelator in the regulation of PD progression.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
Green tea may be considered as a functional food and iron chelator in reduced risk and progression of Parkinson's disease, some scientists suggested
Iron chelation therapy is a primary and standard treatment for patients with iron overload.
Green tea is a precious drink that processes a number of health benefits known to almost everyone in Asia and the Western world.
Parkinson's disease (PD) is a progressive neurodegenerative disease, that causes severe depletion of glutamatergic and dopaminergic inputs in the striatum.
\
Investigation of the green tea EGCG effect in risk and progression of PD has been found to associate to many mechanisms involved in a number of aspects.
Application of metal chelation was found to ameliorate the expression of ROS in the induction of oxidative stress through a chain of reaction and precipitation of aggregation of alpha-synuclein and beta-amyloid peptides deposit in the brain, main leading causes to the onset of PD.
In iron abnormality PD subjects, oxidopamine, also known as 6-hydroxydopamine or 2,4,5-trihydroxyphenethylamine(6-OHD), a neurotoxic synthetic organic compound was found to disrupt iron metabolism, leading to overexpression of the iron induction of dyshomeostasis cause of iron toxicity and oxidative damage in dopaminergic neurons.
Green tea major polyphenol, (−)-epigallocatechin-3-gallate used in metal chelation, ameliorated iron-dependent free radicals located in the subcellular compartments and cellular membranes, through the effect in inhibited iron input and exhibited iron output in brain areas where it preferentially accumulates in neurodegenerative diseases, particularly Parkinsons' disease.
Further analysis of the neurotoxin 6-OHDA causes of iron unstable equilibrium, green extract GECG administration improved the function of hepcidin, a liver-derived hormone in regulated iron dyshomeostasis and gene expression of the iron metabolism through expressions of iron regulatory proteins (IRP1 and IRP2) in regulated the RNA level, between the transcription and the translation of the gene in expression of the iron homeostasis.
Indeed, In the differentiation of neurotoxin 6-OHDA induced iron dyshomeostasis has shown to increase oxidative stress in damage to neuron cells, green extract GECG effects demonstrated a significant inhibition of free radical and iron-free radical expression in the cellular membranes through the antioxidant activities and anti-inflammatory system and expression of nuclear factor-like 2(Nrf2) in stimulated production of antioxidant in protection against oxidative damage during injury and inflammation; heme oxygenase-1(HO-1) in increased production of superoxide dismutase and catalase against ROS and peroxisome proliferator-activated receptor-gamma (PPARγ) in regulated production of pro and anti-inflammatory cytokines and cytokines..
By reducing the overexpression of oxidative damage to neuron cells through regulation of iron-related factors as mentioned above, iron chelator EGCG can counteract these adverse effects and prevent the onset of PD.
Further study of the mechanism on disruption of iron metabolism by 6-OHDA in PD cell line N27, discovered that application of the iron chelator EGCG also disrupts the iron dyshomeostasis in N27 cells (dopaminergic neural cell line) induced by 6-OHDA through regulating iron transporters and regulators expression, such as DMT1 with function in mediation of the entry of dietary iron into these mucosal cells and TfR, a carrier protein for transferrin with function in import iron into the cell and regulated response to intracellular iron concentration and hepcidin, a central regulator in maintain iron homeostasis.
Dysregulation of hepcidin production results in a variety of iron disorders.
Additionally, in 6-OHDA induced neurotoxicity to cause PD, administration of green tea GECG also reduced the intracellular iron retention by decreasing the iron importers and increasing iron exporters, through regulation of the function of iron-regulated transporters, such as ferroportin.
Interestingly, there was a report suggested that the intervention of 3 cups of green tea daily for 3 months improved the antioxidant status and reduced oxidative damage in early PD patients without affecting their iron status.
The findings revealed that green tea bioactive polyphenol, (−)-epigallocatechin-3-gallate may be considered as an iron chelator in the regulation of PD progression.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective Properties of the Standardized Extract from Camellia sinensis (Green Tea) and Its Main Bioactive Components, Epicatechin and Epigallocatechin Gallate, in the 6-OHDA Model of Parkinson's Disease by Bitu Pinto N1, da Silva Alexandre B2, Neves KR3, Silva AH3, Leal LK3, Viana GS1.(PubMed)
(2) Green tea polyphenols prevent Parkinson's disease: in vitro and in vivo studies Dan Chen by Iowa State University
(2) Green tea polyphenols prevent Parkinson's disease: in vitro and in vivo studies Dan Chen by Iowa State University
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