#Phytochemical 3,3'-#Diindolylmethane Inhibits Diseases Associated with Overexpression of #OxidativeStress, Researchers Find

By Kyle J. Norton

Scientists may have found a bioactive ingredient for the treatment of diseases associated with oxidative stress with no side effects, according to studies.

Oxidative stress is a condition caused either by overexpression of free radicals or depletion of antioxidant enzymes produced by the host.

In other words, the condition of oxidative stress occurs only under an imbalance of the ratio of free radicals and antioxidants.

Antioxidants can be either produced by the body or injected into the body from outside sources such as the consumption of antioxidant-rich fruits and vegetables.

Free radicals are everywhere, including the air we breathe, the food we eat and the body daily functioning such as cell metabolism.

In other words, any chemical compound which has an oxygen molecule can become a free radical after entering our body.

Most healthy individuals can produce enough amounts of antioxidants endogenously to counter the bombards of free radicals. However, people with a weakened immune system such as the elderly, and immature immune systems such as babies may need the injection of antioxidants from outside sources.

More precisely, people with a weakened immune system do not produce enough antioxidant enzymes to inhibit the chain reaction of free radicals which occurs daily in the body due to the unstable nature of the molecules.
Believe it or not, our body needs to limit levels of some free radicals to function better, including lower blood pressure, and relax blood vessels to move blood, such as nitric oxide NO.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.

With an aim to find the natural ingredient for the treatment of diseases associated with oxidative stress, researchers investigated the effect of indole-3-carbinol (I3C) and its metabolite, 3, 3'- diindolylmethane (DIM) in type 2 diabetes mellitus (T2DM).

The study included selected genetically modified mice (C57BL/6J mice) similar to that of metabolic abnormalities of the human disease after the administration of a high-fat diet (HFD).


Including indole-3-carbinol (I3C) and its metabolite, 3, 3'- diindolylmethane (DIM) into the diet showed positively modulated glucose, insulin, and Hb and HbA1c levels in HFD mice against the risk of diabetes complications.

Compared to the HFD group, injection of I3C and DIM protected the infected rat against the formation of lipid peroxidation observed by levels of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH), conjugated dienes (CD).


Furthermore, levels of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were also increased, an indication of the balance of the ratio of antioxidants and free radicals.

Interestingly, I3C and DIM also improved the free radical scavengers such as vitamin C, and vitamin E, and improved the reduced glutathione (GSH) levels in treated mice.

Based on the findings, researchers summarized, "From the study, it was clear that the antioxidant-scavenging action was accelerated in mice treated with DIM than the I3C treatment group which was comparable with the standard drug metformin".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and combined with primary medicine for the treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary Glucosinolates Sulforaphane, Phenethyl Isothiocyanate, Indole-3-Carbinol/3,3'-Diindolylmethane: Anti-Oxidative Stress/Inflammation, Nrf2, Epigenetics/Epigenomics and In Vivo Cancer Chemopreventive Efficacy by Fuentes F1, Paredes-Gonzalez X1, Kong AN. (PubMed)
(2) Attenuation of hyperglycemia-mediated oxidative stress by indole-3-carbinol and its metabolite 3, 3'- diindolylmethane in C57BL/6J mice by Jayakumar P1, Pugalendi KV, Sankaran M. (PubMed)

#Healthyfood #ManakuHoney in the Promotion of Regeneration of Tissues Including Cartilage Regeneration, Researchers Find

By Kyle J. Norton

Scientists may have found a golden liquid for the treatment of cartilage damage without inducing any side effects, some studies suggested.

Cartilage is an important structural component placed in the joints of bone with a function to prevent the end of the bone collided from one to another.

Cartilage is a firm tissue but is softer and much more flexible than bone.

Due to the lack of blood vessels connected to the cartilage to supply the chondrocytes with nutrients, repairing the damage to cartilage are more slowly than other tissues.


Cartilage repair is an act to restore the surface of joint cartilage. However, how sufficiency of the work is totally depending on the degree of the damage.

In conventional medicine, cartilage damage due to a single injury, or lesion can be repaired successfully. However, with many lesions in one joint, are less likely to benefit from the surgery. cartilage, particularly in the older population.

In the article "Articular Cartilage Restoration", the American Academy of Orthopaedic Surgeons wrote, "Many procedures to restore articular cartilage are done arthroscopically" and "Some procedures require the surgeon to have more direct access to the affected area. Longer, open incisions are required. Sometimes it is necessary to address other problems in the joint, such as meniscal or ligament tears when cartilage surgery is done"

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered healthy sweet food for replacing the use of white sugar and artificial sweetener. 

With an aim to find the natural ingredient or whole food for cartilage repair in replacement of that conventional medicine with no side effects, researchers at a number of institutes conducted a joint study to evaluate the nature-derived hydrogels, a promising class of scaffolds for cartilage tissue engineering, mimicking the native cellular microenvironment.

Manuka honey-made hydrogels were able to inhibit the proliferation of S. aureus and S. epidermidis clinical isolates and no cytotoxic effects were detected on human mesenchymal stem cells seeded on the hydrogels.

Manuka honey initiated a consistent expression of collagen II and high synthesis of
Sulfated glycosaminoglycans (GAGs) and proteoglycans, thus indicating the formation of the cartilage matrix.

Where Sulfated glycosaminoglycans and proteoglycans are considered promising artificial extracellular matrix components to improve the regeneration of tissues, such as cartilage repair.

These results suggested Manuka honey processes a similar action as those of synthetic substances used for the treatment to improve cartilage regeneration.

In order to understand the effect of Manuka honey in cartilage repair, researchers launched a differentiation of the research paper "Antibacterial effectiveness meets improved mechanical properties: Manuka Honey/Gellan Gum composite hydrogels for cartilage repair", Bonifacio et al.

And suggested that before Manuka honey can be used for the treatment of cartilage repair, there are some criteria that must be met. you can view them at the sources

Due to the limitation of the study, therefore, further data collection large example size, and multi-center studies performed with human consumption of whole food during the course of the disease will be necessary to complete the picture of Manuka honey cartilage repair possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

(1) Antibacterial effectiveness meets improved mechanical properties: Manuka honey/gellan gum composite hydrogels for cartilage repair by Bonifacio MA1, Cometa S2, Cochis A3, Gentile P4, Ferreira AM5, Azzimonti B6, Procino G7, Ceci E8, Rimondini L9, De Giglio E10. (PubMed)
(2) Data on Manuka Honey/Gellan Gum composite hydrogels for cartilage repair by Bonifacio MA1, Cometa S2, Cochis A3, Gentile P4, Ferreira AM4, Azzimonti B3,5, Procino G6, Ceci E7, Rimondini L3,5, De Giglio E1. (PubMed)

#Honey In the Treatment of #AcuteCough and Improvement of Sleep Quality, Researchers Say

By Kyle J. Norton

Scientists may have found a natural whole food that processes a significant activity in reducing the risk and treatment of acute coughing in children with no side effects, some studies suggested.
Coughing can be a natural and reflex reaction to expel phlegm from the airway or a result of viral and bacterial infection of the upper airway.

A cough that lasts less than three weeks is considered an acute cough.

A chronic cough is a medical condition that lasts more than 3 weeks. In children, the condition can be caused by allergies and sinusitis, asthma, whooping cough, cystic fibrosis, aspiration, acid reflux, and a blockage in the airway.


The most common causes of acute cough are cold and flu. However, the chronic condition in adults can be the result of smoking, sinus infection, allergic rhinitis, and diseases associated with upper airway dysfunction, including asthma, chronic bronchitis, and long-term use of angiotensin-converting enzyme (ACE) inhibitors for the treatment of high blood pressure.

The most common symptoms of coughing in children are accompanied by an itchy throat, runny nose, watery eyes, sore throat, or rash.

Most parents use over-the-counter medicine for the treatment of acute coughing in children such as antitussives and expectorants

However, according to the warning from the FDA, warns that children younger than 12 shouldn’t take codeine products to treat pain or cough because of the risk of developing potentially life-threatening breathing problems.

"The FDA recommends against the use of codeine in youths ages 12 through 18 who are obese or have conditions such as obstructive sleep apnea (blocked airflow during sleep) or severe lung disease. These risk factors can increase their chances of developing serious breathing problems when taking these medications".

Therefore, if your child experiences severe coughing, you may want to check your doctor before applying any over-the-counter medicine. Most cases of acute coughing in children are recovered within a few days.

Please noted that there’s no cure for the common cold caused by a viral infection. You will get better on your own in a week or two without needing medications and your child will get better on their own in a week or two without the need for medications.

Honey is a miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one healthy sweet food for replacing the use of white sugar and artificial sweetener.

On finding a natural ingredient or whole food for the treatment of acute coughing accepted by children without inducing any side effects, researchers examined the effectiveness of honey for acute cough in children in ambulatory settings.

The study includes the search of available randomized controlled trials (RCTs) comparing honey, given alone, or in combination with antibiotics, versus nothing, placebo, or other over-the-counter (OTC) cough medications to participants aged from two to 18 years for acute cough in ambulatory settings.

Out of hundreds of studies reviewed by the researchers, only 2 studies were selected for the review.

Compared to dextromethorphan, diphenhydramine, and 'no treatment' on symptomatic relief of cough using the 7-point Likert scale. honey was a much better medicine than no treatment in reducing the frequency of cough and exerted similar or better effects to those of counter medicine.

However, mild adverse events were found in seven children (9.3%) from the honey group and two (2.7%) from the dextromethorphan group.

After taking into account co and confounders, Dr. Oduwole O. the lead scientist said, "There was no significant difference between honey versus dextromethorphan or honey versus diphenhydramine".

Furthermore, in the concerns of the side effects of honey and over-the-counter medicine, researchers examine the effects of two kinds of Iranian honey with diphenhydramine (DPH) on nocturnal pediatric coughs and the sleep quality of children and their parents.

A total of 87 patients included in the study were randomly assigned to one of three treatment groups: Group 1, Honey type 1 (Kimia Company, Iran) (n = 42), Group 2, Honey type 2 (Shahde-Golha, Iran) (n = 25), and Group 3, DPH (n = 20).


Each group received double doses of the respective treatments on two successive nights, researchers indicated that
* Honey type 1 was superior to DPH in improving all aspects of coughs, except the frequency,

* Honey type 2 was more effective than DPH in improving all aspects of coughs, except the sleep quality of the child.

* There was no significant difference between Honey type 1 and 2 in any aspects of cough relief.

After examing the standard validated questionnaire completed by the parents before and after treatment.

Dr. Ayazi P, the lead author wrote in the final report, "Honey may provide better cough relief than DPH in children and improve the sleep quality of children and their parents".

By comparing the above studies, there is no doubt that honey may be used for the treatment of acute cough in children.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Honey for an acute cough in children by Oduwole O1, Meremikwu MM, Oyo-Ita A, Udoh EE. (PubMed)
(2) Comparison of the Effect of Two Kinds of Iranian Honey and Diphenhydramine on Nocturnal Cough and the Sleep Quality in Coughing Children and Their Parents by Ayazi P1, Mahyar A2, Yousef-Zanjani M1, Allami A3, Esmailzadehha N4, Beyhaghi T. (PubMed)

#Antioxidant #Indicaxanthin Inhibits #Diseases Associated with #LipidPeroxidation, Researchers Find

By Kyle J. Norton

Free radical scavengers are antioxidants which process a function to protect the body against the oxidative stress by inhibiting free radical oxidation before they can facilitate a chain reaction or by stopping the chain reaction before they can cause damage to the body.

Free radicals are highly reactive molecules. Internally, they are produced by our body cell metabolism. Externally, free radical can enter our body from the environment sources, such as the air we breathe, the food we eat and the water we drink.

More precisely, any chemicals compounds or molecules which process oxygen atom can be free radicals after chemical interaction.


Believe it or not, free radicals in moderate amounts has benefits the body functioning, such as NO for vascular relaxation.

However, without interfering with the antioxidant, overexpression of free radicals has been found epidemiologically to damage the lipid and protein and induce the alternation of healthy cell DNA, leading to chronic diseases, including arthritis, cardiovascular disease, and diabetes.

Oxidative stress is a result of the imbalanced ratio of the levels of free radicals and antioxidant enzymes in the body.

Out of all damages caused by the overexpression of free radicals, some researchers suggested that lipid peroxidation induced by free radicals has a strong implication in the pathogenesis of various disorders and diseases.

Dr. Kota V. Ramana, the lead scientist in the joint study led by the University of Texas Medical Branch, wrote, "Lipid peroxidation is a complex chain reaction process due to the oxygen-free radicals mediated attack of cell membrane lipids such as polyunsaturated fatty acids (PUFA) resulting in cell damage and dysfunction".

And, "Indeed, a number of preclinical and clinical studies suggest the involvement of lipid peroxidation products in numerous pathological conditions such as inflammation, atherosclerosis, diabetes, aging, neurodegenerative diseases, and cancer".

In other words, an antioxidant with free radical scavenging activity may protect the body against the damage of various cellular components, including proteins, lipids, and DNA in the initiation of diseases.

Indicaxanthin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.

With an aim to find a potential compound for the treatment of diseases involved in oxidative stress, researchers examined the free radical-scavenging activity of indicaxanthin.

According to the tested analysis on the reaction of the phytochemical indicaxanthin with lipoperoxyl radicals generated in methyl linoleate methanol solution by 2,2'-azobis(2,4-dimethylvaleronitrile), and in aqueous soybean phosphatidylcholine unilamellar liposomes by 2,2'-azobis(2-amidinopropane) hydrochloride,

* Indicaxanthin incorporated in liposomes prevented lipid oxidation.

* The free radical scavenging property was found to be concentration-dependent, but not linearly related to the phytochemical concentration.

* In liposome, indicaxanthin showed a significant delay against oxidation, particularly in that of the lower concentration.

* However, in the corporation with alpha-tocopherol, Indicaxanthin exhibited cooperative antioxidant effects and reciprocal protective interactions.

Taken altogether, indicaxanthin processes strong free radical scavenging activity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Kinetics of the lipo peroxyl radical-scavenging activity of indicaxanthin in solution and unilamellar liposomes by Tesoriere L1, Allegra M, Butera D, Gentile C, Livrea MA. (PubMed)
(2) Lipid Peroxidation Products in Human Health and Disease 2014 by Kota V. Ramana, 1 ,* Sanjay Srivastava, 2 and Sharad S. Singhal. (PMC)

#Healthyfood #Honey Improves #Chemotherapy For Treatment of #Cancers by Inhibiting the Chemo-toxicity, According to Studies

By Kyle J. Norton

Honey may be considered an adjunct therapy combined with the chemo drug in the improvement of the drug efficacy and reduction of chemo toxicity for the treatment of cancers, some scientists found.
Cancer is a class of chronic diseases characterized by cell growth irregularly and disorderly in the tissue of specific organs, depending on the type of cancer.

Most cases of cancer are the result of the alternation of DNA in the cell located on the surface of the inner lining of an organ. Most patients may not experience any symptoms at the early stage.

However, as cancer progresses, the continued growth tumor may cause pressure on the nearby healthy organs and nerve cells, leading to localized symptoms and severe pain.

At the 4th stage of cancer, malignant cells may metastasize to other organs a distance away from the original site.

According to the statistic from the National Cancer Institute, approximately, 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes.

In 2017, over 15,000 children and adolescents ages, 0 to 19 were diagnosed with cancer, and 1,790 died of the disease.
Chemo drugs are medicine used for the treatment of cancer by killing cancer cells that have been spread to other tissue or organ.

Chemotoxicity is the side effect of chemo drugs
Most common symptoms of chemo drugs include the effect of blood-forming cells in the bone marrow, on hair follicles and cells in the mouth, digestive tract, and reproductive system, probably due to the medicine designed to kill cells indiscriminately.

According to the information from the pharmaceutical company, doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented by mankind.

The chemo drug used to treat a wide variety of cancers can kill cancer at every point in their life cycle.
Unfortunately, the drug can also damage heart cells and cause serious side effects, such as hair loss, breathlessness, feeling sick and easily infected.
Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered healthy sweet food for replacing the use of white sugar and artificial sweetener.

On finding a natural ingredient or whole food which processes chemopreventive properties and anti-chemo toxicity during cancer treatment, researchers evaluate the effect of Kelulut honey (KH), produced by the stingless bees from Trigona species against colon cancer induced in the animal model.

A total of 24 male Sprague Dawley rats aged 5 weeks are included in the study.
Rats were divided into 4 groups: (G1) untreated group not induced with AOM, (G2) untreated group induced with AOM, (G3) treated group induced with AOM, and (G4) treated group not induced with AOM.
Injection of AOM (15 mg/kg) was via intraperitoneal route once a week for two subsequent weeks to induce colorectal cancer.
The treatment groups were given oral administration of KH (1183 mg/kg body weight) twice daily for 8 weeks.

AOM injected group showed a significant increase in the total number of aberrant crypt foci (ACF) and aberrant crypts (AC) and crypt multiplicity and damage to liver and kidney

After treatment of KH, AOM group displayed a reduction of crypts and chemotoxicity by restoring the liver and kidney function observed by blood profile.

Furthermore, KH was not toxically identified by the KH-treated group not induced with AOM.

These results suggested that KH may have a potential effect on inhibiting the toxicity caused by chemotherapy and improving the chemo drug's activity without inducing any side effects.


Moreover, on finding a natural whole food to overcome 5-fluorouracil (5-FU) therapeutic resistance and adverse toxicity in colorectal cancer, researchers looked into Manuka honey (MH), a rich source of bioactive compounds to examine its anticancer effects on human colon cancer HCT-116 and LoVo cells.

Compared to 5-FU alone, MH synergistically enhanced the chemotherapeutic effects of 5-FU, by reducing cell proliferation through the suppression of enzymes and proteins associated with the function in stimulating cancer cell multicity and activation of pathways associated to cell death programming.

Combined with chemo drug 5-FU, MH promoted the expression of antibody production and production of ROS in the induction of cytotoxicity activity against cancer cells without causing harm to the nearby cells and tissue.

This result was observed by the reducing antioxidants produced by the cancer cells and increasing oxidative stress in the tumor.

Additionally, MH also induced cancer cell apoptosis through cell cycle arrest.

The findings clearly indicated MH could be a useful preventive or adjuvant agent in the treatment of colorectal cancer with 5-FU by inhibiting the toxicity and cancer cell resistance.

Taken altogether, KH and MH can be considered functional foods for the prevention and adjunct therapy combined with the primary medicine for the treatment of cancer without inducing chemotoxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Chemopreventive Properties and Toxicity of Kelulut Honey in Sprague Dawley Rats Induced with Azoxymethane by Saiful Yazan L1, Muhamad Zali MF2, Mohd Ali R3, Zainal NA2, Esa N4, Sapuan S4, Ong YS4, Tor YS4, Gopalsamy B2, Voon FL2, Syed Alwi SS. (PubMed)
(2) Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes, and suppressing metastasis ability by Afrin S1, Giampieri F1, Forbes-Hernández TY1, Gasparrini M1, Amici A1, Cianciosi D1, Quiles JL2, Battino M. (PubMed)

#Healthyfood #Turmeric In the Improvement of #HepaticSteatosis in Obesity, Researchers Show

By Kyle J. Norton

The liver is the largest internal organ that not only plays an essential role in cleansing the blood coming from the digestive system before passing them to other parts of the body but secrets cholesterol to aid digestive function, produce steroid hormones and vitamin D, and build strong cell walls.

Steatosis is a condition caused by abnormal retention of lipids within a cell or organ. Hepatic steatosis is a medical condition caused by the accumulation of fat in the liver.

In other words, if the fat of your liver is more than 5% of your liver weight, you are considered to have hepatic steatosis. Over time, untreated hepatic steatosis can lead to advanced forms of nonalcoholic fatty liver disease which have been found to induce negatively the function of the liver, particularly. in patients with obesity associated with alcohol intoxication and/or hepatic disorders.

There are several mechanisms involved in the accumulation of intrahepatic fat, including increased flux of fatty acids to the liver, increased de novo lipogenesis, and/or reduced clearance through β-oxidation or very-low-density lipoprotein secretion.

People who are obese, having the condition of insulin resistance or diabetes, dyslipidemia, hypertension, metabolic syndrome, rapid weight loss, use hepatotoxic medications total parenteral nutrition (TPN) are at an increased risk of hepatic steatosis.

Conventionally, there is no effective treatment for liver steatosis. However, treatment of liver steatosis in obese patients is focusing to reduce weight and symptoms and improve quality of life, totally depending on the severity of the disease.

Usually, weight loss through a combination of a healthy diet and exercise is also the first line of treatment. in patients with an advanced stage of liver fibrosis, (cirrhosis) liver transplantation may be an option.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural compound for the prevention of liver steatosis, researchers examined the alleviation effect of KBH-1, an herbal mixture of Saururus chinensis, Curcuma longa, and Polygala tenuifolia in obesity-induced hepatic steatosis.

The experiment included HepG2 cells, primary neuronal cells, and a high-fat diet (HFD)-induced obesity rat model in vitro and in vivo.

According to the tested assays, KBH-1 not only suppressed the lipid deposition in HepG2 cells exposed to free fatty acids (FFA) but also significantly inhibited major factors in lipogenesis associated with the formation of fat and promoted major factors in lipolysis involved in the breaking down of fats.

In the high fat-induced obesity model, KBH-1 improved hepatic steatosis by alleviating the effects on lipogenic genes and kinases similar to those in vitro.

Furthermore, KBH-1 significantly improved the leptin-mediated signals that regulate food intake, energy expenditure, and metabolism,.. impaired by obesity or FFA in the obesity model.


Moreover, according to the HPLC analysis, onji-saponin B and curcumin found in the formula have also potently suppressed the level of triglycerides.

In other words, KBH-1 activated the expression of AMP-activated protein kinase (AMPK) associated with the regulation of energy metabolism that stimulates glucose uptake and lipid oxidation to produce energy and suppressed the expression of PPARγ involved in hepatic steatosis... in obesity.


Based on the findings, researchers wrote, "These findings show the potential of KBH-1 as a functional food supplement or preventive agent in the treatment of obesity (.associated with hepatic steatosis)".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of hepatic steatosis in obese, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) KBH-1, an herbal composition, improves hepatic steatosis and leptin resistance in high-fat diet-induced obese rats by Lee JH1, Lee JJ1, Cho WK1, Yim NH1, Kim HK2, Yun B2, Ma JY. (PubMed)
(2) The effects of herbal composition Gambigyeongsinhwan (4) on hepatic steatosisand inflammation in Otsuka Long-Evans Tokushima fatty rats and HepG2 cells by Yoon S1, Kim J1, Lee H1, Lee H1, Lim J1, Yang H2, Shin SS3, Yoon M. (PubMed)

Green Tea and Its' Polyphenols (GTPs) May Process Anti-Melanoma and Non-Melanoma #SkinCancers Activities, According to Studies

By Kyle J. Norton

Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, inducing "yin excessive syndrome" or "yang vacuity syndrome" including weakened immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Skin cancer is a medical condition characterized by irregular cell growth in the tissues of the skin. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.

According to statistic, approximately, 87,110 new cases of invasive melanoma are diagnosed in the U.S every year

The evaluation of the green tea effect in overexposure to environmental solar ultraviolet (UV) radiation (290-400 nm) which has been found to increase the risk of the development of melanoma and non-melanoma skin cancers in mice model showed that oral administration of green tea polyphenols (GTPs) in drinking water or the topical application of EGCG prevents UVB-induced skin tumor development in tested subjects.

Particularly, (-)-Epigallocatechin-3-gallate (EGCG), the major and most photoprotective polyphenolic component of green tea also exhibited a protective activity against UV in the induction of skin cancer, through induction of immunoregulatory cytokine interleukin (IL) 12 in differentiation of naive T cells into Th1 cells and acted as T cell-stimulating factor in stimulate the growth and function of T cells.

Moreover, interleukin (IL) 12 also demonstrated a significant effect as an antagonist against immunosuppression induced by solar/ultraviolet (UV) radiation by restoring immune responses and also stimulating DNA repair.

Further analysis also indicated that green tea (-)-Epigallocatechin-3-gallate (EGCG) also inhibited UV in the induction of skin tumors; angiogenetic effect in stimulated production of new blood vessels to
provide nutrients and oxygen for cancer cells proliferation and survival and initiated cytotoxic T lymphocyte cells in induced cancer and infectious and damaged cells apoptosis.


Interestingly, an additional study of green tea polyphenols (GTPs) in prevention of UVB irradiated (80 mJ/cm(2)) 3 times each week for 24 wk in induced skin cancer in mice divided into group consumed water and a group fed with water containing 2 g/L GTPs, showed that group treated with GTPs displayed a significant reduced UVB-induced tumor incidence by 35%, tumor multiplicity by 63%, and tumor growth by 55% in compared to the non-treatment group.

Group treated with GTPs+UVB also demonstrated a reduced expression of the matrix metalloproteinases (MMP)-2 and MMP-9, which are activator associated with progression from benign to advanced cancer and enhanced expression of specific endogenous tissue inhibitors of metalloproteinases (TIMPs), tissues inhibitor of MMP in skin tumors in compared to mice treated with UVB alone.

Furthermore, GTPs+UVB group also reduced expressions of CD31 and vascular endothelial growth factor, in the activated development of new blood vessel to nourish skin tumor cells proliferation and site expansion and inhibited expression of proliferating cell nuclear antigen, a key factor in DNA replication and cell cycle regulation in skin cancer in compared to UVB group.

More importantly, mice treated with the GTPs+UVB group also showed more cytotoxic CD8(+) T cells in the tumors compared to the UVB group by exhibiting greater activation of caspase-3 expression in induced apoptosis of the tumor cells.

The information findings suggested a potential and therapeutic effect of green tea and its bioactive polyphenols (GTPs) in attenuating the risk, progression, and treatment of melanoma and non-melanoma skin cancers.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green Tea Prevents Skin Cancer by Two Mechanisms by Navid Bouzari, Yvonne Romagosa, Robert S. Kirsner(PubMed)
(2) Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair by Katiyar S1, Elmets CA, Katiyar SK.(PubMed)
(3) Orally administered green tea polyphenols prevent ultraviolet radiation-induced skin cancer in mice through activation of cytotoxic T cells and inhibition of angiogenesis in tumors by Mantena SK1, Meeran SM, Elmets CA, Katiyar SK.(PubMed)