#GreenTea' #Polyphenols (GTPs) in Attenuating the Risk of Osteoporosis through Their Antioxidant Activity in Vivos

By Kyle J. Norton

Green tea may have a therapeutic and positive effect in reduced onset. progression and treatment of osteoporosis, some scientists suggested.

Green tea is a precious drink that processes a number of health benefits known to almost everyone in Asia and the Western world.

Osteoporosis is a chronic condition characterized by progression in reduced bone mass and deterioration of bone tissue and is considered a major health problem in both elderly men and women.


In the study to evaluate the effects of ingestion of green tea and green tea's bioactive compounds in mitigating bone loss and risk of osteoporotic fractures in both elderly women and men, researchers found that the application of green tea and its bioactive compounds exert significant activities in the reduced onset of osteoporosis, through its antioxidants and its initiation of the production of natural antioxidant in the body such as glutathione and enzymes (e.g., catalase and superoxide dismutase) in inhibited the levels of ROS in facilitated the chain reaction.

Truly, the overexpression of free radicals has been associated with the change in the balance between activities of osteoblasts and osteoclasts, leading to osteoclasts in destroyed the calcified tissue and induced bone remodeling.

These results demonstrated a significant decrease in the risk of fracture by improving bone mineral density and preventing free radicals in damage the bone-forming osteoblasts while suppressing osteoclastic activities.

Moreover, in the review of the effect of green tea and its bioactive components on bone health, researchers indicated that ingestion of green and its bioactive compound displays an impressive Osteo-protective impact on bone mass and microarchitecture in various bone loss models associated with aging, sex hormone deficiency, and chronic inflammation.


The implication of reduced onset and progression of osteoporosis in the aging population due to sex hormone deficiency of the study may be attributed to green tea and its bioactive compound in increased levels of osteocalcin, a bone formation marker, decreased serum of tartrate-resistant acid phosphatase (TRAP), a bone resorption marker and improved the body in absorption of calcium.


In fact, the serum of serum levels of osteocalcin (OC) and tartrate-resistant acid phosphatase (TRAP) is considered an effective measurement of the rate of bone turnover in patients with osteoporosis.

Interestingly, the application of green tea and its bioactive compound was also found to modulate the expression of proinflammatory cytokines in the regulation of osteoblasts and osteoclasts, by inhibiting the production of C-reactive protein (CRP) production in the liver in demonstrated inflammation by reduced levels of interleukin-1 and 6(IL-1-6) and tumor necrosis factor-alpha (TNF-α), the sensitive markers of systemic inflammation.

This differentiation was supported by the study in the evaluation of the efficacy of green tea polyphenols (GTPs) at mitigating bone loss and microstructure deterioration along with related mechanisms in 40 androgen-deficient aged male rats, a model of male osteoporosis, randomly assigned to received A 2 (sham vs. orchidectomy) × 2 (no GTP and 0.5% GTP in drinking water) for 16 weeks.

At the end of the experiment, researchers found that rats treated with GTP demonstrate increased serum osteocalcin concentrations, bone mineral density, and trabecular volume, number, and strength of femur; increased trabecular volume and thickness and bone formation in both the proximal tibia and periosteal tibial shaft; decreased eroded surface in the proximal tibia and endocortical tibial shaft; and increased liver glutathione peroxidase activity.

These results indicated a strong implication of green tea polyphenols in decreased cortical and trabecular bone loss and increased both bone density by stimulated overexpression of bone formation and reduced bone resorption via antioxidant capacity.

Taken together, green tea and its bioactive polyphenols may be considered a functional food in ameliorated early-onset, progression and combined with standard medicine for the treatment of osteoporosis. However, the intake of green tea supplements should be taken with extreme care due to recent reports of acute liver toxicity.


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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Green tea and bone metabolism by Shen CL1, Yeh JK, Cao JJ, Wang JS. (PubMed)
(2) Green tea and bone health: Evidence from laboratory studies by Shen CL1, Yeh JK, Cao JJ, Chyu MC, Wang JS. (PubMed)
(3) Supplementation with green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats by Shen CL1, Cao JJ, Dagda RY, Tenner TE Jr, Chyu MC, Yeh JK.(PubMed)

#Antioxidant #Myricetin and #Quercitrin Found in #Cranberry Protects the Body Against Bacterial Infection in Vitro

By Kyle J. Norton

Infection is a condition caused by a harmful microbial invasion of the body's tissues
Most cases of bacterial infection are treated with antibiotics. However, bacterias are very adaptable, and overuse of antibiotics has been found to make them resistant to antibiotics.

Out of trillions of strains of bacteria in the world, only a few cause diseases in humans. Believe it or not, our gut contains trillion microorganisms, most of which are bacteria.

The most common symptoms of bacterial infection are redness and heat, swelling, fever, and pain at the site of infection.

In severe cases, the patient may also experience symptoms of swollen lymph glands.

Most cases of bacterial infection are treated successfully if the types of bacteria that cause the infection are identified.

There are many risk factors associated with the onset of bacterial infection, people with severe chronic disease may increase the prevalence of bacterial infection, particularly in those with cirrhosis.

Dr. Deschênes M, the lead scientist at the Université de Montréal wrote, "Bacterial infection is a frequent and severe complication of cirrhosis. Cirrhotic patients admitted for gastrointestinal bleeding are at high risk of such a complication and have been targeted in trials of antibiotic prophylaxis".

And, " patients with severe cirrhosis who are admitted for gastrointestinal bleeding have a higher risk of developing a bacterial infection during their hospitalization than other cirrhotic patients".

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of bacterial infection, researchers examined the effect of cranberry antibacterial activity against uropathogenic strains of Escherichia coli (UPEC).

According to the tested analysis, the whole extract showed a powerful antibacterial activity against UPEC compared to the selected fractions that presented a different behavior.

Myricetin and quercitrin demonstrated the highest decrease in E. coli biofilm formation compared with the control and other fractions.

However, other chemical constituents such as dihydro ferulic acid glucuronide, procyanidin A dimer, quercetin glucoside, myricetin, and prodelphinidin B led to a significant decrease of the surface hydrophobicity compared with the control.

In other words, all fractions in the cranberry extract worked synergistically to protect the host against the infection caused by E. coli

Based on the results, researchers said, "Apart from proanthocyanidins, other compounds, mainly flavonoids, can act against E. coli biofilm formation and also modify UPEC surface hydrophobicity in vitro."

Taken altogether, cranberry may be considered a remedy for the prevention and treatment of bacterial infection, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antibacterial activity of isolated phenolic compounds from cranberry (Vaccinium macrocarpon) against Escherichia coli by Rodríguez-Pérez C1, Quirantes-Piné R2, Uberos J3, Jiménez-Sánchez C1, Peña A4, Segura-Carretero A. (PubMed)
(2) In Vivo Consumption of Cranberry Exerts ex Vivo Antiadhesive Activity against FimH-Dominated Uropathogenic Escherichia coli: A Combined in Vivo, ex Vivo, and In Vitro Study of an Extract from Vaccinium macrocarpon by Rafsanjany N1, Senker J1, Brandt S1, Dobrindt U2, Hensel A. (PubMed)
(3) Risk factors for the development of bacterial infections in hospitalized patients with cirrhosis by Deschênes M1, Villeneuve JP. (PubMed)

#Coffee Intake Daily Reduces the Risk of #MetabolicSyndrome, Studies Fing

By Kyle J. Norton

Coffee consumed daily and regularly may have a substantial and potential effect in blocking the onset of metabolic syndrome, some scientists suggested.
Metabolic Syndrome is a group of risk factors associated with the development of cardiovascular disease and type 2 diabetes, including high blood pressure, abnormally high blood cholesterol, and triglyceride levels,.....

According to the statistic, about a quarter of the US population have metabolic syndrome, and the numbers are increasing at an alarming rate.

The Western diet with a high on saturated and trans, refined sugar, salt, and processed foods, is associated with the early onset of the condition.

Dr. Christos Pitsavos, in the evaluation of the effect of diet on the risk metabolic syndrome, wrote, "People with the metabolic syndrome may benefit from intensive lifestyle modifications including dietary changes and adopting a physically more active lifestyle".

These statements suggested that everyone can prevent the development of the syndrome through modification of their daily diet accompanied by a change to a healthy lifestyle.

The doctor continued, " During the last decades increasing scientific evidence has emerged that protective health effects can be obtained from diets that are rich in fruits, vegetables, legumes, and whole grains, and which include fish, nuts, and low-fat dairy products. Such diets need not be restricted in total fat intake as long as energy intake does not exceed caloric expenditure and if they emphasize predominantly vegetable oils that have a low content of saturated fats and partially hydrogenated oils".

Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the West, made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.

According to the searching of a database of PubMed and the China National Knowledge Infrastructure (CNKI) for relevant articles published between 1 January 1999 and 31 May 2015, including 11 published reports and 13 studies with a total of 159,805 participants eligible for our meta-analysis, the relatively odd risk ratio of metabolic syndrome between the highest vs lowest category of coffee consumption was 0.872

The review also observed a nonlinear relationship between coffee and coffee caffeine consumption in the amelioration of risk of metabolic syndrome, by dose-response analysis.

Additionally, in a cross-sectional population-based survey of 8,821 adults (51.4% female) conducted in Krakow, Poland. to evaluate the coffee and tea consumption and risk of metabolic syndrome, using food frequency questionnaires, researchers after the observation of the questionnaire returned from participants expressed that there is an interesting association between high coffee consumption of 3 cups and the clusters of lower BMI, waist circumference, systolic and diastolic blood pressure, triglycerides, and higher HDL cholesterol compared to those drinking less than 1 cup/day.

The study apparently indicated that people drinking 3 cups of coffee daily and regularly have a favorably ameliorated risk of metabolic syndrome even after adjusting for potential confounding factors.

More importantly, the study also pointed out that high coffee consumption was negatively associated with waist circumference, hypertension, and triglycerides in women but not in men.

Furthermore, in the animal evaluation of the effect of coffee drinking on clinical markers of diabetes and metabolic syndrome in Zucker rats including Diabetic Zucker rats with metabolic syndrome and control Zucker rats, researchers at the Fluminense Federal Institute showed that animals received daily doses of coffee by gavage for 30 days express a substantially decreased risk of metabolic syndrome by reducing serum glucose, total cholesterol, and triglycerides, compared to non-treatment group.

Dr. Abrahão SA, the lead researcher said, "The results demonstrate that treatment with roasted coffee drink, because of its hypoglycemic and hypolipidemic effect, is efficient in the protection of animals with metabolic syndrome and diabetes mellitus type 2".

The findings from the above studies suggested that coffee drinking daily and regularly have a favorably profound effect in decreasing the risk of metabolic syndrome, particularly in women.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299
Sources
(1) Coffee consumption and risk of the metabolic syndrome: A meta-analysis by Shang F1, Li X1, Jiang X2.(PubMed)
(2) Association of daily coffee and tea consumption and metabolic syndrome: results from the Polish arm of the HAPIEE study by Grosso G1,2, Stepaniak U3, Micek A3, Topor-Mądry R3, Pikhart H4, Szafraniec K3, Pająk A3.(PubMed)
(3) Diet, Exercise and the Metabolic Syndrome by Christos Pitsavos, Christos Pitsavos, Demosthenes Panagiotakos,, Michael Weinem, and Christodoulos Stefanadis. (PMC)

#Healthyfood #BroccoliSproutJuice Inhibits the Risk of Neuro-Toxicity Associated with #Oxidativestress, According to Studies

By Kyle J. Norton

Neuroprotection is an action involved in the use of a natural substance to protect the integrity of neurons against damage or death.
In other words, neuroprotection is the process to protect brain functioning.

Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

The most common disease associated with neurodegenerative diseases is dementia, a cluster of conditions including Parkinson’s, Alzheimer’s, and Huntington’s disease, leading to a negative influence on the body's functioning, including balance, movement, talking, breathing, and heart function.

There is no single cause of the progressive death of brain neurons. Epidemiologically, genetic preposition, and medical conditions, such as alcoholism, brain cancer, or a stroke in the brain are some of the most common prevalent factors found in patients with neurological diseases

A prolonged period of toxins and toxic chemicals accumulated that affects brain function also has a strong impact to induce the onset of the disease.

Symptoms of neurotoxicity are totally depending on the degree of toxicity. Some symptoms may take some time to develop. However, in most cases, symptoms may appear immediately after exposure.

Depending on the area and location of neuron damage, weakness or numbness, loss of memory, vision, headache change of cognitive and behavioral and sexual dysfunction are the most common symptoms found in people with neurotoxicity.

According to the WHO, neurological disorders, ranging from epilepsy to Alzheimer's disease, from stroke to headache, affect up to one billion people worldwide.

In older adults, the increase in age has been found to affect the progressive onset of neurodegenerative diseases.

Dr. Hung CW and colleagues wrote, " In the human body, it is estimated that cell division and metabolism occur exuberantly until about 25 years of age. Beyond this age, subsidiary products of metabolism and cell damage accumulate, and the phenotypes of aging appear, causing disease formation".

And, " Among these age-related diseases, neurodegenerative diseases have drawn a lot of attention due to their irreversibility, lack of effective treatment, and accompanied social and economical burdens".

Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie had large flower heads, usually green in color and the mass of flower heads is surrounded by leaves that is evolved from a wild cabbage plant on the continent of Europe.


On finding a potent compound for the protection against brain disease, researchers examined the neuroprotective effect of broccoli sprouts on SH-SY5Y cells.

According to the results of the SH-SY5Y cells used in the study were treated with the fragment Aβ 25-35 by two crude juices of broccoli sprouts containing different amounts of phenolic compounds, researchers found that Aβ-induced cytotoxicity and apoptotic cell death were inhibited by the administration of both juices.

In other words, both juices protected the integrity of the neurons and inhibited the nuclear chromatin condensation and apoptotic body formation induced by Aβ injection.

The efficacy of broccoli sprout juice against the neuro-toxicity was attributed to the modulation of the mitochondrial function and the HSP70 gene transcription and expression that dissociate cytotoxic stress in the neurons.

Furthermore, oxidative stress in the brain tissues was also ameliorated by the juices by increasing the host levels of antioxidant enzymes such as heme oxygenase-1, thioredoxin, thioredoxin reductase.

More precisely, broccoli sprout juice protected the neuron against toxicity by dissociating cytotoxic and oxidative stress.

In the comparison of the neuroprotection of 2 juices, researchers said, "Although the effects of the two juices were similar, the juice enriched in phenolic compounds showed greater efficacy in inducing the activation of the Nrf2 signaling pathway (involved in systematic inflammatory response)".

Taken altogether, broccoli sprouts may be considered a functional food for the promotion of brain health, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Neuroprotective Effect of Brassica oleracea Sprouts Crude Juice in a Cellular Model of Alzheimer's Disease by Masci A1, Mattioli R2, Costantino P2, Baima S3, Morelli G3, Punzi P4, Giordano C5, Pinto A1, Donini LM1, d'Erme M6, Mosca L. (PubMed)

(1) Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson's Disease by Morroni F1, Sita G1, Djemil A2, D'Amico M3, Pruccoli L3, Cantelli-Forti G3, Hrelia P1, Tarozzi A. (PubMed)
(3) Ageing and neurodegenerative diseases by Hung CW1, Chen YC, Hsieh WL, Chiou SH, Kao
CL. (PubMed)

#Healthyfood #Honey, a Natural and Potential Compound for Hangover Relief, Scientists Say

By Kyle J. Norton

Traditional medicine suggested that the intake of one spoonful of honey before and after a drinking party may prevent a hangover.

According to Dr. Zhou, a scientist in the field of TCM, honey processes cooling, hydrating, and revitalizing properties and has been used in traditional Chinese medicine as purifying stimulant and a tonic against dizziness and hangover-upset stomachs.

A hangover is the unpleasant physiological and psychological effect caused by the (over) consumption of alcohol, according to studies.

The most common symptoms of a hangover include headache, drowsiness, concentration problems, dizziness, fatigue, and gastrointestinal discomfort.

The exact causes of the hangover are unknown. The most common factor associated with a hangover is the accumulation of acetaldehyde, a highly toxic substance.

The conversion of acetaldehyde is a chemical process as a result of the enzyme alcohol dehydrogenase (ADH) which metabolizes the alcohol intake to acetaldehyde.

Depending on the individual variations in alcohol metabolism, some people may experience worse hangover symptoms than others.

Hangover symptoms are affected by alcohol tolerance which is measured by the bodily responses to the functional effects of ethanol in alcoholic beverages.

CYP2E1, one of the genes has been linked with alcohol tolerance. However, people with high alcohol tolerance are also more likely to develop alcoholism.

Dr. Claire Heit,, the lead scientist in the evaluation of the role of CYP2E1 in alcohol metabolism wrote, "Acetaldehyde (the direct metabolite of ethanol oxidation) contributes to many aspects of the behavioral effects of ethanol. Given acetaldehyde cannot pass through the blood-brain barrier, its concentration in the CNS is primarily determined by local production from ethanol".

And, "Catalase and cytochrome P450 2E1(CYP2E1) represent the major enzymes in the CNS that catalyze ethanol oxidation. CYP2E1 is expressed abundantly within the microsomes of certain brain cells and is localized to particular brain regions".


Honey, the rich golden liquid is a miraculous product made by bees using nectar from flowers.

The liquid is considered one of the healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

Scientists on finding a natural and potential compound for hangover relief examined the traditional medicine use of honey for preventing drunkenness and relieving hangover symptoms.


Intoxicated male mice selected for the study were assigned randomly either to low or high doses of lychee flower honey (2.19 or 4.39 g/kg body weight, respectively) that were single orally administrated 30 min before the ethanol intoxication of mice, followed by recording the locomotor activity by autonomic activity instrument and observing the climbing ability after alcohol or 2.19 g/kg honey that was single orally administrated 5 min after the ethanol intoxication of mice, followed by determining the ethanol concentration in mice blood.

Both doses of honey increased the autonomic activity of alcoholized mice.

Furthermore, intoxicated mice treated with 2.19 g/kg honey showed a decrease significantly of blood ethanol concentration.

Additional differentiation suggested that The anti-intoxication activity of honey is attributed to the effect of the fructose contained in the honey.

Interestingly, honey inhibited hangover symptoms without affecting the levels of oxidative stress and antioxidant enzymes produced by the host.

The results showed that honey processed a direct anti-hangover activity in a dose-time-dependent manner.

Taken altogether, honey may be considered a functional remedy to relieve hangover symptoms caused by alcoholic intoxication, pending the confirmation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Honey reduces blood alcohol concentration but not affects the level of serum MDA and GSH-Px activity in intoxicated male mice models by Shi P1,2, Chen B3, Chen C1, Xu J3, Shen Z1, Miao X4,5, Yao H. (PubMed)
(2) The Role of CYP2E1 in Alcohol Metabolism and Sensitivity in the Central Nervous System
Claire Heit, Hongbin Dong,b Ying Chen, David C. Thompson,c Richard A. Deitrich,d and Vasilis Vasiliou. (PMC)
(3) Curing hangovers the Chinese way by Timeout

#Healthyfood #Onion Improves the Levels of Antioxidant Enzymes in the Liver, Researchers Show

By Kyle J. Norton

The liver is the largest internal organ and the only organ in the human body that can regenerate itself.
The liver is the first line of the bodily toxin defense by filtering the blood that comes from the digestive tract, before passing them to the rest of the body.

The liver also produces cholesterol that plays a critical role in building a strong cell wall, producing steroid hormones and vitamin D, and aiding the digestive function in food absorption and detoxifying chemicals and metabolizes drugs.

The hepatoprotective or liver protective effect is an action that maintains the healthy function of the liver against any harmful toxins.

Symptoms of liver diseases include jaundice, abdominal pain, swelling, swelling in the legs and ankles, itchy skin, dark urine, pale stool color, and a tendency to bruise easily.

There are no exact causes of liver disease. Viruses, toxins, genetics, alcohol, and unknown causes are some prevalent factors found in patients with chronic liver disease, inclduing cancer.

In the US, most cases of liver disease are a result of hepatitis viral infection and autoimmune diseases. Infectious viral hepatitis can produce toxins to protect them against the antioxidant enzymes produced by the host body and prevent the attack of the systematic immune response.

Furthermore, in recent years, excessive alcohol drinking has been found to induce alcoholic liver disease in many parts of Asia and America.


The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.


Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound that processes liver protective activity, researchers examined the effects of onion and garlic extracts on cadmium (Cd)-induced liver oxidative damage in rats.

The study included
* Cd group was challenged with 3CdSO(4).8H(2)O (as Cd; 1.5 mg/kg bw per day per oral) alone, and
* The extract-treated groups were pretreated with varying doses of onion and/or garlic extract (0.5 and 1.0 ml/100 g bw per day per oral) for a week and thereafter co-treated with Cd (1.5 mg/kg bw per day per oral) for 3 weeks.


Based on the tested differentiation, the Cd group showed a significant increase in the levels of lipid peroxidation and glutathione S-transferase, whereas antioxidant enzymes such as glutathione, superoxide dismutase, and catalase levels were decreased in the liver.

Furthermore, liver oxidative stress markers such as alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase were also found to increase in the Cd group.

In other words, Cd showed induced oxidative damage in rat liver.

Injection of garlic and onion extract not only inhibited all parameters in the Cd group but also exerted a liver protective effect in a dose-dependent manner.

Based on the findings, researchers wrote, "high dose of onion and a moderate dose of garlic extracts possibly via reduced lipid peroxidation and enhanced antioxidant defense system that is insufficient to prevent and protect Cd-induced hepatotoxicity".

Taken altogether, onion may be considered a remedy for the prevention and treatment of liver alcoholic cytotoxicity pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Hepatoprotective effect of quercetin: From chemistry to medicine by Miltonprabu S1, Tomczyk M2, Skalicka-Woźniak K3, Rastrelli L4, Daglia M5, Nabavi SF6, Alavian SM7, Nabavi SM. (PubMed)
(2) Hepatoprotective potentials of onion and garlic extracts on cadmium-induced oxidative damage in rats by Obioha UE1, Suru SM, Ola-Mudathir KF, Faremi TY. (PubMed)

#Herbal #Turmeric Inhibits the Infection Caused by #RespiratorySyncytialVirus (RSV) Without Harming the Healthy Cells

By Kyle J. Norton

Infectious diseases are disorders induced by organisms, including bacteria, viruses, fungi, or parasites.
Out of trillions of organisms present on the earth, only a few hundred have been known to cause diseases.
Most infectious diseases are passed from person to person through direct or indirect contact with the infected patient. Others can be transmitted by insects or animals.

However, infectious diseases, the most prevalent in third-world countries are acquired by ingesting contaminated food or water.

Infectious diseases share the common symptoms of fever, diarrhea, muscle aches, coughing, and fatigue similar to those of influenza. Other symptoms are totally depending on the types of organisms including bacteria, and viruses.

In conventional medicine, except for viral infection, organism induced infection can be treated with

antibiotics. If you are taking antibiotics for the treatment of chronic infection, please make sure that you know all the side effects for preventive measures.

Believe it or not, most cases of infectious disease were stopped in the acute phase of infection. In which the immune system activated the first line of defense by destroying the pathogen before they have the chance of multiplication.

However, people with a weakened immune system such as the elderly, and immature immune systems such as infants are prone to infectious diseases.

Dr. Mouton CP, the lead scientist in the analysis of the immune system and disease associated with infection in the elderly wrote, "Infectious diseases account for one-third of all deaths in people 65 years and older... A change in mental status or decline in function may be the only presenting problem in an older patient with an infection. An estimated 90 percent of deaths resulting from pneumonia occur in people 65 years and older" and "Mortality resulting from influenza also occurs primarily in the elderly".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to discover a natural antiviral infection for the treatment of infectious diseases, researchers examined the effect of β-cyclodextrin (CD) functionalized graphene oxide (GO) composite, against the respiratory syncytial virus (RSV), which is considered the major viral pathogen of the lower respiratory tract of infants.

According to the results from the tissue culture infectious dose assay and immunofluorescence assay, curcumin-loaded functional GO exerted a significant activity in the inhibition of RSV infection.

Furthermore, curcumin-loaded functional GO improved greatly the biocompatibility of the host cells.

In other words, the composite inhibited the infection caused by the respiratory syncytial virus (RSV) without causing harm to the healthy cell in the tested cells.

Dr. the leads scientist after taking into account co and confounders wrote, "the composite could prevent RSV from infecting the host cells by directly inactivating the virus and inhibiting the viral attachment, and possessed prophylactic and therapeutic effects towards the virus.


Taken altogether, turmeric may be considered a supplement for the prevention and combined with chemical compounds for the treatment of viral infection, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric as a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin as an Adjunct Drug for Infectious Diseases by Padmanaban G1, Rangarajan PN. (PubMed)
(2) Synergistic antiviral effect of curcumin functionalized graphene oxide against respiratory syncytial virus infection by Yang XX1, Li CM, Li YF, Wang J, Huang CZ. (PubMed)
(3) Common infections in older adults by Mouton CP1, Bazaldua OV, Pierce B, Espino DV. (PubMed)