#Healthyfood #CollardGreens Inhibit the Parameters That Increase the Risk of Obesity in Vivos, Researchers Find

By Kyle J. Norton

Obesity is a chronic condition characterized by excess body fat accumulated over time. People with a BMI of over 30 is considered obese.

Similarly, overweight is a condition of excess body weight relative to height. People with a BMI ranged from 25 to 29.9 is careonsidered overweight.

According to the statistics, 68% of the American population is either overweight or obese. Obesity has been found to induce adverse effects in country'snearly every system of the human body, leading to increased risk of numerous diseases, including diabetes and cardiovascular disease.

Furthermore, the rate of obesity in the US and Canada continues to climb at an alarming rate, leading to significant burdens to the country economy and health care system.

Epidemiologically, the most common symptoms of obesity are breathlessness, increased sweating, inability to cope with physical activity, feeling very tired every day, back and joint pains, low confidence, and self-esteem and feeling isolation

According to the CDC, the most common complications associated with obesity are coronary heart disease, stroke, type 2 diabetes, cancer of breast, colon, endometrial, gallbladder, kidney, and liver and sleep apnea.

Currently, there is no effective treatment for reducing the disease. However, some researchers suggested powerful environmental factors that influence eating and physical activity may be the best in combating obesity.

Bariatric surgery is used as an option for management that causes a reduction in the amount of food you are or a reduction in the absorption of calories from the food you eat, or both.

The surgery has been proposed for patients with extreme obesity (BMI of 40 or higher) due to weight-induced a serious weight-related health problem, such as diabetes or high blood pressure.

Furthermore, this type of surgery has posed a serious risk to many patients if the commitment to making lifelong changes in eating and exercise habits cannot be followed through.

Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.

To find a natural food for the prevention and treatment of obesity, researchers examined the effect of sulforaphane found abundantly in collard greens.

In a high-fat diet (HFD)-induced obesity in C57BL/6N mice that were fed a normal diet (ND), HFD or HFD plus 0.1% sulforaphane (SFN) for 6 weeks, researchers found that SFN administration not only attenuated HFD-induced visceral adiposity that stored around several important internal organs such as the liver, pancreas and intestines, adipocyte hypertrophy associated with an enlargement of adipose tissue but also ameliorated fat accumulation in the liver.

Furthermore, SFN decreased the elevated levels of serum total cholesterol and leptin, and liver triglyceride in HFD-SFN-fed mice compared to HFD-fed mice.

SFN also inhibited the expression of a gene associated with the promotion of inflammation in the adipose tissue of HFD-SFN mice and increased the adiponectin function in regulating glucose levels and fatty acid breakdown.

Moreover, reductase expression associated with the production of cholesterol was decreased and an antibody associated with fatty acid utilization was increased in the lycopene treatment group compared with HFD-fed mice.

Taken altogether, collard green processed abundantly SFN may be considered supplements for the prevention and treatment of obesity, pending the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Potential effects of sulforaphane to fight obesity by Martins T1, Colaço B1,2, Venâncio C1,2, Pires MJ1,3, Oliveira PA1,3, Rosa E1, Antunes LM. (PubMed)
(2) Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice by Kyeong-Mi Choi, Youn-Sun Lee, Wonkyun Kima, Seung Jung Kimb, Kyong-Oh Shina, Ji-YeonYuc, Mi Kyeong Lee, Yong-Moon Lee, Jin Tae Honga, Yeo-PyoYuna, Hwan-SooYooa. (Science Direct)

#Healthyfood #KidneyBeans Exhibit Gut Functioning In Ameliorated Obesity in Doses Depended Manner, Researchers Find

By Kyle J. Norton

Intake of kidney beans regularly may reduce the risk of complications in obese patients, a study conducted by a renowned institute insisted.
Kidney bean is popular because of its kidney shape, strong flavor, and color of reddish-brown in nature, genus Phaseolus, belonging to the family Fabaceae. The bean is often an excellent dietary selection with no cholesterol, but a good source of protein and minerals.

Obesity is a medical condition of excess body fat that has accumulated over time. According to the Body Mass Index(BMI), a BMI of over 30 is an indication of obesity. Unfortunately, 68% of the American population is either overweight or obese.

According to the Instituto Tecnológico de Durango,, kidney beans may have potential effects as natural alternative treatments of some metabolic alterations associated with obesity.

The efficacy may involve the regulation of many aspects, including a lipid profile, and lipid and carbohydrate metabolisms, in addition to anti-inflammatory and antioxidant activities.

The study also found that kidney beans exerted a similar anti obese effect on that of green tea and its active principles, in both in vitro (cell cultures) and in vivo (animal models).

In fact, the test of different levels of lectin of kidney bean (Phaseolus vulgaris) content (27 g/kg meal) in a high-quality (lactalbumin) control diet in obese Zucker (FFA) rats and their lean littermates, phytochemical compound, bean lectin as a dietary adjunct or therapeutic agent expressed a stimulated gut function and ameliorated obesity, in doses depended manner. The result also indicated that a safe and effective dose range of bean lectin can be established for human subjects.

Furthermore, standardized and purified P. vulgaris extract (PVE), when employed as a supplement in a mixed balanced meal (60 % carbohydrates, 25 % lipids, and 15 % protein), in a randomized, double-blind, placebo-controlled of 12 volunteers, exerted a significant on hypometabolic and appetite control affecting satiety sensations and lower desire to eat.

But further studies are needed to prove the concept of kidney beans as a supplement used as a functional food in balanced meals in obese, glucose-intolerant, and diabetic subjects.

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Sources
(1) Plants with potential use on obesity and its complications by Gamboa-Gómez CI1, Rocha-Guzmán NE1, Gallegos-Infante JA1, Moreno-Jiménez MR1, Vázquez-Cabral BD1, González-Laredo RF1.(PubMed)
(1) Lipid accumulation in obese Zucker rats is reduced by the inclusion of raw kidney bean (Phaseolus vulgaris) in the diet by Pusztai A1, Grant G, Buchan WC, Bardocz S, de Carvalho AF, Ewen SW.(PubMed)
(3) Phaseolus vulgaris extract affects glycometabolic and appetite control in healthy human subjects by Spadafranca A1, Rinelli S, Riva A, Morazzoni P, Magni P, Bertoli S, Battezzati A.(PubMed)

#Antioxidant #Lycopenes Inhibit #SkinCancer Cell Migration and Proliferation in Vitros, Researchers Suggest

By Kyle J. Norton

Skin cancer is a medical condition associated with irregular cell growth in the skin tissues.
Most cases of skin cancer start in the cells on the surface of the outermost inner lining tissue before penetrating into deeper layers.

After growing in size at the advanced stage, the cells of the tumor may travel a distance away to infect other healthy tissue and organs through blood and fluid circulation.

The mAmericansost common secondary metastasis of skin cancer is breast, lung, and colon.

Believe it or not, more people are diagnosed with skin cancer each year in the U.S. than all other cancers combined. As of today, there are 58 million American living with skin cancer.

Approximately, 1 in 5 Americans will develop skin cancer by the age of 70.

If you have experienced some of the symptoms such as a sore that doesn't heal or comes back after healing, pale white or yellow flat areas that look like scars, raised and scaly red patches, small, smooth, and shiny lumps that are pearly white, pink or red, a pink growth with raised edges and indents in the center and a growth that has small blood vessels on the surface of the skin, you may be on the early stage of skin cancer, please check with your doctor immediately.

The 5-year survival among all people with melanoma of the skin is 92% compared to 100% for those with localized skin cancer.

Out of many prevalent factors that cause skin cancer, some researchers suggested exposure to UVB are one most risk associated with skin cancer onset in the US.

Dr. Calzavara-Pinton P, the lead scientist said, "BCC is much more strongly related to measures of intermittent ultraviolet exposure (particularly those of childhood or adolescence) than to measures of cumulative exposure".

And, " In contrast, SCC is more strongly related to constant or cumulative sun exposure. Photobiological studies have clarified that sunlight and UVB radiation are complete carcinogens for AK and SCC although the relationship with UVA exposure is much less known".

Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

In the urgency to find a natural compound for the treatment of skin cancer without side effects, researchers evaluated the effect of lycopene, a kind of carotenoid inhibitory function on skin tumor cell migration.

In the human sSCC cell line COLO-16 selected for the study, the administration of lycopene inhibited the cell proliferation and migration of COLO-16 cells without affecting the normal keratinocytes.

Furthermore, the inhibitory activity was found by exhibiting Zonula occludens (ZO)-1, inhibition of ZO-1 expression and its failure to accumulate at cell junctions (ZO-1 and claudin-1) have been found to induce cancer progression.

In other words, lycopene inhibited the SCC cell line COLO-16 proliferation by enhancing the expression of the tight junction complexes that regulate the permeability of epithelial against cancer cells.

Additionally, cell cycle division proteins (JNK and ERK ) in the induction of mitogen associated with the decreasing levels of ZO-1 and claudin-1 were also inhibited by the injection of lycopene.

More precisely, lycopene inhibited the progression of human sSCC cell line COLO-16 by reducing the proteins involved in promoting cell cycle division and increasing cancer cell permeability and autophagy,

Based on the findings researchers said, "This study indicates that lycopene might be a useful chemopreventive agent against cSCC".

Taken altogether, lycopene may be considered a supplement for the prevention and treatment of skin cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene upregulates ZO-1 and downregulates claudin-1 through autophagy inhibition in the human cutaneous squamous cell carcinoma cell line COLO-16 by Bi S1,2, Li L1, Gu H1, Li M1, Xu S1, Bu W1, Zhang M1, Zhou Z2, Chen X. (PubMed)
(2) Suppressive effects of lycopene and β-carotene on the viability of the human esophageal squamous carcinoma cell line EC109 by Ngoc NB1,2, Lv P1,3, Zhao WE1. (PubMed)

Antioxidant #Anthocyanin Found in Herbal #Bilberry Processes Anti #Diabetes Activities in Clinical Trials, Researchers Show

By Kyle J. Norton

In seeking natural therapy with no side effects, scientists may have a whole berry for the treatment of type 2 diabetes, according to studies.

Type 2 diabetes is a medical condition caused by not enough insulin entering the bloodstream to convert blood glucose into energy. Insulin resistance is a hallmark of patients with the disease.

Insulin is a hormone with a function to regulate the movement of sugar into your cells. In other words, insulin converts sugar to energy to fuel the body's needs.

Most cases of type 2 diabetes is a result of not enough insulin produced by the pancreas due to reduced numbers of healthy beta cells or the insulin produced was not used properly due to the clogged up of the insulin receptor sites.

Type 2 diabetes is an acquired disease in adulthood. In the Western world, most cases of type 2 diabetes are associated with obesity induced by a long-term poor diet and lack of exercise.

Truly enough, over 68% of the population in the US are either overweight or obese.

According to the statistics in the US, in 2015, 30.3 million Americans, or 9.4 percent of the U.S. population and another 84.1 million had confirmed diabetes and prediabetes, respectively.

Sadly, the majority of people with prediabetes don't know they had it.

Therefore, losing weight, eating well, and moderate exercise daily can help to manage the disease against the onset of hyperglycemia, a major cause of the diabetic complication.

People with type 2 diabetes who can not manage the disease through weight loss, healthy diet, and exercise are commonly treated with medications or insulin therapy.

Please make sure you know all the side effects if you are currently taking any form of therapy for diabetic treatment.

The most common symptoms of type 2 diabetes depending on the severity of the stages include increased thirst, frequent urination, unintended weight loss, fatigue,

In severe cases, patients may also experience symptoms of a wound that does heal, blurred vision, and frequent infection and areas of darkened skin.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

In finding potential ingredients for the treatment of type 2 diabetes, researchers examined the bilberry content of anthocyanins and polyphenols which have been proven to process antidiabetic activity in several studies.

Injection of anthocyanins and polyphenols exhibited an increase in insulin secretion (anthocyanin pelargonidin), reduction of insulin resistance (anthocyanin cyanidin-3-glucoside), and glucose resorption from the GIT (polyphenols) and enhancement of beta-cells regeneration associated with the diabetics.

In the examination of the single ingredient anthocyanins, researchers found the compounds also contribute to the improvement of the lipid spectrum compared to that of acarbose and atorvastatin, according to many preclinical and clinical studies.

Furthermore, the compound derivatives anthocyanin cyanidin-3-galactoside also have antioxidant, anti-inflammatory, and cardioprotective activities.

In order to reveal more information about bilberry antidiabetic effects, researchers at the joint study led by the University of Eastern Finland differentiated the serum hippuric acid changes after intake of bilberry.

InA a total of 47 individuals with features of the metabolic syndrome, were randomly assigned to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12).comapred to from fasting serum samples at baseline and after an 8-week intervention, researchers showed that fasting serum hippuric acid increased significantly (3.5-fold) only in the BB group and correlated with changes in fasting plasma glucose concentration and insulin secretion.

These results suggested bilberry's anti-diabetic property not only confirms the Finnish Diabetes Prevention Study but also improves glycemic control and pancreas β-cell function which is reduced in patients with type 2 diabetes.

Dr. the lead scientist wrote after taking into account co and confounders in the final report, "Fasting serum hippuric acid is increased after consumption of anthocyanin-rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β-cell function".

Taken altogether, bilberry-processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the treatment of type 2 diabetes with no side effects, pending Norton'sthe validation of a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To ProfessionalsProfessional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes by de Mello VD1, Lankinen MA1, Lindström J2, Puupponen-Pimiä R3, Laaksonen DE4, Pihlajamäki J1,5, Lehtonen M6,7, Uusitupa M1,8, Tuomilehto J2,9,10, Kolehmainen M1, Törrönen R1, Hanhineva K. (PubMed)
(2) [Effectiveness of phytotherapy in the supportive treatment of type 2 diabetes mellitusBillberry (Vaccinium myrtillu)].[Article in Czech] by Koupý D, Kotolová H, Kučerová J. (PubMed)

#healthyfood #Greentea and its #EGCG Inhibit the Overexpression of #OxidativeStress That Causes #Fibromyalgia, Researchers Suggest

By Kyle J. Norton


Green tea may have a therapeutic and positive effect in reduced risk, progression, and treatment of
fibromyalgia caused by oxidative stress, some scientists suggested.

Green tea, a precious drink processes a number of health benefits known to almost everyone in Asia and the Western world.

Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain affecting over 10 million (3.6% of the population) people in the US alone.

According to the study in the review of literature on the frequency and pattern of complementary and alternative medicine (CAM) of 289(95%) patients who completed the survey (263 women and 26 men) between February 2003 and July 2003, green tea was recommended at 24% for treatment of fibromyalgia (FM).

In other words, in herbal medicine, green tea is considered to have a certain effect in reducing the symptoms and treatment for such a syndrome.


Some evidence in medical literature suggested that the overproduction of ROS in the induction of oxidative stress may have a strong implication in the pathophysiology of FM.

In the investigation of the effect of green tea epigallocatechin-3-gallate (EGCG) in the protection of oxidative stress to cardiac cells cultured in the conditions of control, 400 μM H2O2 exposure for 30 min with and/or without 10 to 20 μM EGCG pre-treatment, researchers at the National Tsing Hua University found that treatment of green tea in H(2)O(2) group demonstrated a significant reduction of levels of reactive oxygen species through its antioxidant and its ability in induced production of natural antioxidant present in the cardiac cells in compared to overexpression of ROS in H2O2 treatment group without injection of EGCG.

Also, the application of green tea reduced levels of cytosolic Ca2+ overload in the H(2)O(2) group in induced oxidative stress in experiment cell apoptosis through improved antioxidant protein.

Interestingly, EGCG inhibited the ameliorated H(2)O(2) expression in increased glycolytic protein in response to the degree of oxidative stress in the cultured cells and α-enolase, a key glycolytic enzyme on the surface of several cell types in the contribution of impaired glycolytic activity through oxidative and nitrative stress.

Additionally, green tea EGCG also decreased levels of peroxiredoxin-4, an antioxidant with function in protection against oxidative stress by detoxifying peroxides and mitochondrial proteins with the function of redox reactions of oxidative phosphorylation.

After taking into account other confounders, researchers suggested that ingestion of green tea EGCG inhibited the damage of the H(2)O(2) group through inhibition of the downstream signaling for Akt in expression glucose oxidation and cell apoptosis in cellular processes and loss of phosphorylation of GSK-3β and cyclin D1 depletion in facilitated oxidative stress.

These results postulated that green tea EGCG exerted a similar inhibited effect of those of GSK-3β inhibitor (SB 216763) in significantly improved H(2)O(2)-induced suppression on cell viability, phosphorylation of pAkt (S473) and pGSK-3β (S9), and level of cyclin D1 in cells.


The above differentiation was supported by the study conducted by the Universidad de Sevilla, in evaluating some evidence of green tea in reduced oxidative stress in facilitated pathophysiology of FM in initiated signs and symptoms of muscular alteration and mitochondrial dysfunction.

Truly, in the primary rat model, administration of green tea EGCG in different concentrations for 24 h before being exposed to hydrogen peroxide (H(2)O(2)) for 2 h to induce oxidative stress, researchers found that pretreatment with 10, 25, and 50 µM EGCG significantly inhibited the expression of H2O2 in a reduced substantial decrease in cell viability.

Further analysis also showed that green tea EGCG application dose of 50 µM ameliorated the proportion of propidium iodide (PI)-positive cells increased in cultures caused by H(2)O(2) injection, thus reducing H(2)O(2) in induced cell death.

Taken together, green tea and its bioactive polyphenols EGCG may be considered a functional food in reduced risk, progression, and treatment of fibromyalgia caused by overexpression of oxidative stress. However, the intake of green tea supplements should be taken with extreme care as acute liver toxicity has been reported in a number of medical literature.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Use of complementary and alternative medical therapies by patients referred to a fibromyalgiatreatment program at a tertiary care center by Wahner-Roedler DL1, Elkin PL, Vincent A, Thompson JM, Oh TH, Loehrer LL, Mandrekar JN, Bauer BA.(PubMed)
(2) Oxidative stress and mitochondrial dysfunction in fibromyalgia by Cordero MD1, de Miguel M, Carmona-López I, Bonal P, Campa F, Moreno-Fernández AM(PubMed)Molecular identification for epigallocatechin-3-gallate-mediated antioxidant intervention on the H2O2-induced oxidative stress in H9c2 rat cardiomyoblasts by Chen WC, Hsieh SR, Chiu CH, Hsu BD1, Liou YM.(PubMed)
(3) Molecular identification for epigallocatechin-3-gallate-mediated antioxidant intervention on the H2O2-induced oxidative stress in H9c2 rat cardiomyoblasts by Chen WC, Hsieh SR, Chiu CH, Hsu BD1, Liou YM.(PubMed)

#Healthyfood #Cranberry May Improve the Postprandial Blood Glucose in High Fat Diet, Researchers Find

By Kyle J. Norton

Postprandial blood glucose is the range of blood glucose that is measured by the blood glucose test, taken after 2 hours of a meal.

At this point of measurement, postprandial blood glucose in a healthy individual usually goes back down. In other words, lower or equal to 7.8 mmol/L (140 mg/dL) 2 hours after eating are normal blood glucose found in a healthy individual.

Glycemic response is a change in blood glucose after consuming a carbohydrate-containing food compared to Glycemic Index (GI) which ranks carbohydrate-containing foods, according to their effect on blood glucose levels.

In other words, the glycemic response is the change of blood glucose after the intake of a food or meal.

More precisely, healthy people who do not have prediabetes or diabetes have normal blood glucose and insulin levels that rise within the range after eating, then return to the fasting levels over a short period.

According to the 2015 statistics by the American Diabetes Association, in the U.S. over 30.3 million Americans, or 9.4% of the population are living with diabetes. Sadly, out of 30.3 million adults with diabetes, 23.1 million were diagnosed, and 7.2 million were undiagnosed.

In 2015, 84.1 million Americans age 18 and older had prediabetes.

According to epidemiological studies, by managing postprandial blood glucose effectively, diabetics can decrease the risk of microvascular (retinopathy, nephropathy, and neuropathy) and cardiovascular disease (CVD).

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of diabetes, researchers investigated the postprandial effects of dried cranberries following a high-fat breakfast challenge in obese participants with type 2 diabetes (T2DM).

The randomized crossover trial includes blood draw and vascular measurements such as fasting, 1, 2, and 4 hours (h), following the consumption of a fast-food style high-fat breakfast (70 g fat, 974 kcal) with or without cranberries (40 g).

According to the results of the analysis, biomarkers associated with inflammation and oxidative markers such as interleukin-18 and malondialdehyde were significantly lower at 4 h.

Serum total nitrite was found to be higher at 2 h in the cranberry compared to the control group.

However, there were no significant differences in levels of insulin, insulin resistance, lipid profiles, and blood pressure between the cranberry and control group.

Furthermore, cranberries showed no effect on the levels of C-reactive protein or interleukin-6.
In other words, dietary cranberries inhibited the high-fat breakfast-induced postprandial glucose and selected biomarkers of inflammation and oxidation in patients with T2DM without affecting other parameters associated with diabetes such as insulin, insulin resistance, lipid profiles, and blood pressure.

Based on the findings, researchers said, "Adding whole cranberries to a high-fat meal may improve postprandial blood glucose management and warrant further investigation".

Taken altogether, cranberry may be considered a remedy used for postprandial blood glucose management, pending t the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cranberries improve postprandial glucose excursions in type 2 diabetes buSchell J1, Betts NM, Foster M, Scofield RH, Basu A. (PubMed)
(2) Impact of Cranberry Juice Enriched with Omega-3 Fatty Acids Adjunct with Nonsurgical Periodontal Treatment on Metabolic Control and Periodontal Status in Type 2 Patients with Diabetes with Periodontal Disease by Zare Javid A1, Maghsoumi-Norouzabad L1,2,3, Ashrafzadeh E1,2,3, Yousefimanesh HA4, Zakerkish M5, Ahmadi Angali K6, Ravanbakhsh M2, Babaei H. (PubMed)

#Antioxidant #Indicaxanthin In the Prevention of #Diseases Associated with #Atheromas, Researchers Find

By Kyle J. Norton

An atheroma, or atheromatous plaque ("plaque"), is an abnormal accumulation of plaque in the inner layer of the wall of an artery, found in most adults, a leading cause of atherosclerosis.
Atherosclerosis is a condition caused by long-term plaques built-up on the wall of the arteries, leading to the narrowing arteries, a major cause of cardiovascular disease (CVD)

CVD is a medical condition involved in blood vessels. CVD can be heart disease or stroke depending on the location of a blood clot that causes blockage of the blood flow in the artery.

According to the statistics provided by the European Heart Network, cardiovascular disease (CVD) causes 3.9 million deaths in Europe and over 1.8 million deaths in the European Union (EU) every year. In 2015, approximately, 11.3 million new cases of CVD in Europe and 6.1 million new cases of CVD in the EU were diagnosed.

Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood.

Atheromatous plaques build up in the arteries can be classified into several stages, including
* Stage 1 is the foam cells of macrophage and fatty deposits are localized on blood vessel walls.

* Stage 2 Type II is various thread-like fibers or filaments accumulated on the arterial wall.

* Stage 3 is connective tissue deposition on the arteries is thicker.

Stage 1-3 is most frequently found in patients with hypertension, diabetes mellitus, hypercholesterolemia, and who smoke.

* Stage 4 and 5 Type IV and V are conditions that the softer plaque with a thinner fibrous cap containing macrophages and smooth muscle cells are formed.

Atherosclerosis at the early stage is asymptomatic. However, in stage 4 and 5, patients may experience symptoms of chest pain, pain in their leg, and arm, particularly in the area of a blocked artery, shortness of breath, fatigue muscle weakness due to reduce blood flow in the artery.

Indicaxanthin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.

In finding a potent compound for the treatment of atheromas, 7-Ketocholesterol (7-KC)-induced apoptosis of macrophages is considered a key event in the development of human atheromas.

In human atheromatous by the 7-Ketocholesterol (7-KC), researchers found that* The induction of atheromatous plaque within 24 h of injection of 7-KC was associated with the induced cytotoxicity by elevating the expression of intracellular reactive oxygen species over basal levels.
* Furthermore, levels of preceding NADPH oxidase-4 (NOX-4) over-expression and elevation of cytosolic Ca²⁺ associated with an imbalanced ratio of free radicals and antioxidants were also induced by the administration of 7-KC.

* Moreover, the progressive depletion of total thiols that cause oxidative stress was also promoted by the 7-KC
* Additionally, the redox-sensitive NF-κB involved in the inhibition of oxidation was also de-promoted by 7-KC activation.

* Co-incubation of 2·5 μm of Ind not only completely prevented 7-KC-induced pro-apoptosis in the tested cells but also decreased the parameters that lead to the risk of atheromas.

Based on the findings, researchers said, "( Indicaxanthin( a highly bioavailable dietary phytochemical, may exert protective effects against atherogenesis toxicity of 7-KC at a concentration of nutritional interest".

Taken altogether, indicaxanthin may be considered a remedy for the prevention and treatment of atheromas, pending the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phytochemical indicaxanthin suppresses 7-ketocholesterol-induced THP-1 cell apoptosis by preventing cytosolic Ca(2+) increase and oxidative stress by Tesoriere L1, Attanzio A, Allegra M, Gentile C, Livrea MA. (PubMed)