#Phytochemical #Carotenoids Inhibit the Risk of Age-Related #MacularDegeneration, According to Clinical Trials

By Kyle J. Norton

Age-related macular degeneration is a condition caused by the deterioration of the small central portion of the retina, known as the macular degeneration.

Macular degeneration happened mostly in adults over 60 and is one of the major causes of vision loss.

The exact causes of macular degeneration are not identified. As of today, researchers cannot explain why some elderly are susceptible to macular degeneration while others do not.

However, researchers do know that certain risk factors have been found epidemiologically to induce the risk of macular degeneration including aging, the disease has been found most commonly in people over 50, family history and genetics, race, and macular degeneration is more common in Caucasians.

Smoking, obesity and medical condition such as cardiovascular disease are also associated with a higher risk of macular degeneration

There are 2 forms of macular degeneration found in the elderly
* The dry form is caused by the presence of yellow deposits, called drusen under the retina, in the macula. However, the elderly with increased was not at a higher risk of macular degeneration.

* The wet form is caused by the growth of abnormal blood vessels from the choroid, the vascular layer of the eye, underneath the retina.

Compared to the loss of vision of 10% of patients induced by the wet form, most patients of macular degeneration have the dry form which has been found to cause loss of some central vision.

Some researchers suggested that macular degeneration may also be caused by an unhealthy diet. Dr. Martha P. Montgomery wrote, "A 97-item Block food frequency questionnaire was used to gather diet information, and overall diet quality was measured using the Healthy Eating Index (HEI) and Alternate Healthy Eating Index (AHEI)".

And, "Participants in the highest quartile of diet quality had significantly reduced odds of AMD according to the AHEI score (0.54, 95% confidence interval 0.30 – 0.99) and non-significantly reduced odds of AMD according to the HEI (0.75, 0.41 – 1.38). Odds of AMD were also 51% lower in the highest quartile of fish intake compared to the lowest quartile (odds ratio = 0.49, 0.26 – 0.90)".


These results strongly suggested the risk of AMD is many folds higher in people who follow the Western diet compared to those who follow the Oriental diet.

Carotenoids is a class of mainly yellow, orange, or red fat-soluble pigments, including lycopene and carotene, found abundantly in ripe tomato, pumpkins, carrots, corn, and daffodils.

In finding a potential ingredient for the treatment of age-related macular degeneration (AMD), researchers examined the beneficial role of carotenoids in the prevention of AMD.


Epidemiologically, in a case-control study by comparing the risk AMD in subjects with late AMD, exudative AMD, and retinal pigment abnormalities with the presence of drusen, and an equal number of control subjects,
*Administration of lutein and zeaxanthin-induced serum concentrations was not associated with the risk of AMD.


* Consumption of food sources of lutein and zeaxanthin (carotenoids) was associated with reducing the risk of macular degeneration.

* People with higher levels of lutein and zeaxanthin in the blood have a lower risk of AMD.


However, the reduced risk of lutein and zeaxanthin for AMD when levels of the carotenoids are elevated in the serum or diet was not consistent.


Based on the findings, researchers wrote, "Until scientifically sound knowledge is available we recommend for patients judged to be at risk for AMD to alter their diet to more dark green leafy vegetables, wear UV protective lenses and a hat when outdoors".

Taken altogether, carotenoids, particularly lutein, and zeaxanthin may be considered a remedy for the prevention and treatment of age-related macular degeneration, pending the confirmation of the larger sample size and multicenter human study.

Intake of carotenoids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) The role of the carotenoids, lutein, and zeaxanthin, in protecting against age-related macular degeneration: A review based on controversial evidence by Maneli Mozaffarieh,1 Stefan Sacu,1 and Andreas Wedrich. (PMC)
(2) Overall diet quality and age-related macular degeneration by Martha P. Montgomery, M.H.S., Freya Kamel, Ph.D., M.P.H., Margaret A. Pericak-Vance, Ph.D., Jonathan L. Haines, Ph.D., Eric A. Postel, M.D., Anita Agarwal, M.D., Marie Richards, Ph.D., William K. Scott, Ph.D.,* and Silke Schmidt, Ph.D. (PMC)

#Healthyfood #Coffee Intake > 2 cups/day May Associate with with an Increased Risk Type 1 Diabetes, Researchers Show

By Kyle J. Norton

Whole food ingredients in the herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single-ingredient isolated from such plants may induce opposite responses.
Coffee has become a popular and social beverage all over the world, particularly in the West, is a drink made from roast beans from the Coffea plant, native to tropical Africa and Madagascar.

Intake of coffee in adulthood may increase the risk of autoimmune diabetes or type 1 diabetes, a study by the Institute of Environmental Medicine, Karolinska Institutet suggested.

In a population-based case-control study with incident cases of adult-onset (≥ 35 years) diabetes, including 245 cases of latent autoimmune diabetes in adults (glutamic acid decarboxylase antibody positive), 759 cases of Type 2 diabetes (glutamic acid decarboxylase antibody negative), together with 990 control subjects without diabetes, randomly selected from the population, after inspection of the returned questionnaire, researchers found that coffee intake may be associated with an increased risk of high glutamic acid decarboxylase antibody latent autoimmune diabetes in adults.

The relative odd ratio of these populations was 1.11 compared to non-drinkers.
The risk of disease development increased by 15.2% (P = 0.0268) for every additional cup intake.

Dr. Löfvenborg JE, the lead author said, "Coffee may be associated with the development of autoimmunity and possibly an increased risk of more Type 1-like latent autoimmune diabetes in adults".

More importantly, in the review of the association between coffee intake, its influence on the immune system, and the insurgence of the most relevant autoimmune diseases conducted by the joint study led by Tel-Aviv University coffee intake showed a selective both in increased(rheumatoid arthritis (RA) and type 1 diabetes mellitus (T1DM)) and decreased(multiple sclerosis, primary sclerosing cholangitis, and ulcerative colitis) risk of some autoimmune diseases.

Particularly in type 1 diabetes, Dr. Sharif K, the lead author said, "Coffee intake led to a decrease in insulin sensitivity in T1DM" and " coffee consumption was shown to influence disease course and management options".

Remarkably, in the study of some diabetic children younger than 15 years, and diagnosed from September 1986 to the end of April 1989, with 600 newly diagnosed diabetic children and 536 randomly selected population-based children, researchers postulated that the risk for type 1 diabetes was increased in the children who consumed at least 2 cups of coffee daily compared to other groups. even after adjusting to other odd factors.


The findings suggested that coffee intake daily and regular may have a significant impact on the increased development of type 1 diabetes in children and adults population regardless amount of cup intake. therefore, people with a family history of type 1 diabetes should reduce their intake of fewer than 2 cups of coffee per day.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Coffee consumption and the risk of latent autoimmune diabetes in adults--results from a Swedish case-control study by Löfvenborg JE1, Andersson T, Carlsson PO, Dorkhan M, Groop L, Martinell M, Rasouli B, Storm P, Tuomi T, Carlsson S.(PubMed)
(2) Coffee and autoimmunity: More than a mere hot beverage! by Sharif K1, Watad A1, Bragazzi NL2, Adawi M3, Amital H1, Shoenfeld Y4.(PubMed)
(3) Is children's or parents' coffee or tea consumption associated with the risk for type 1 diabetes mellitus in children? Childhood Diabetes in Finland Study Group by Virtanen SM1, Räsänen L, Aro A, Ylönen K, Lounamaa R, Akerblom HK, Tuomilehto J.(PubMed)

#Herbal #Bilberry Inhibits the Early Parameters Associated with the Onset of #GastricUlcer, According to Studies

By Kyle J. Norton

Gastric, stomach ulcer is an oval sore found on the lining of the stomach.
A gastric ulcer is one of the most common types of peptic ulcer disease which affects both the stomach and small intestines.

According to epidemiological studies, gastric ulcer is caused either by the infection of the bacterium Helicobacter pylori (H. pylori) or long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin.

The most common symptoms are a burning sensation or pain in the stomach. Most patients with gastric ulcers have pain that intensifies on an empty stomach, depending on the severity of the condition.

Some patients with gastric ulcers also experience persistent dull pain in the stomach, unintended weight loss, nausea or vomiting and bloating, and acid reflux.

If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility of a gastric ulcer.

Conventionally, most cases of gastric ulcer can be treated successfully depending on the cause, including medicine or surgery if the medicine failed.

Out of many risk factors that cause a gastric ulcer, some researchers suggested there is a correlation between obesity and gastritis as well as gastric ulcers.

Dr. Nadia B. Pietrzykowska said, "Excess body weight has been linked to various abdominal ailments. These may include abdominal pain, bloating, vomiting, heartburn, diarrhea, or constipation".

And, "Scientific studies are also increasingly reporting a correlation between obesity and gastritis as well as gastric ulcers. A recent, large study that specifically focused on analyzing gastric and duodenal ulcers confirmed that excess weight predisposed individuals to gastric ulcers when compared to their normal-weight counterparts".

Bilberry is a species of low-growing shrub in the genus Vaccinium, belongings to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.

In the testing of the effect of Vaccinium myrtillus L. Anthocyanoside (VMA) used as a folk medicine to treat diseases related to gastric ulcers in northern Europe, researchers investigated the protective effects of VMA on gastric mucosal damage in a murine gastric ulcer model.

During the experiment, oral administration of VMA (10, 30, and 100 mg/kg) significantly protected gastric mucosa against HCl/ethanol-induced gastric ulcers.

VMA protected the stomach by inhibiting lipid peroxide levels in a concentration-dependent manner and exhibiting high scavenging activity against the superoxide anion radical (·O(2) (-) ) and the hydroxyl radical (·OH).

The antioxidant activity in VMA was found to be attributed to the presence of anthocyanidins and delphinidin.

Based on the findings, Dr. Ogawa K, the lead scientist said, "These findings indicate that the protective effects of VMA on HCl/ethanol-induced gastric mucosal injury may be partially due to the antiperoxidative effects of anthocyanidins".

In order to provide more information about VMA gastric protective effects, researchers examined the antiulcer effects of 3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl)-1-benzopyrylium chloride (IdB 1027,
an anthocyanidin from Vaccinium myrtillus) in various experimental models.

Orally, IdB 1027 inhibited all parameters associated with the onset of gastric ulcerations including anti-inflammatory drugs, ethanol, reserpine, histamine, and duodenal ulceration induced by mercaptamine.

Furthermore, IdB 1027 also protected the stomach against chronic gastric ulcers induced by acetic acid.

Moreover, IdB 1027 in the rat model did not affect gastric secretion in pylorus-ligated rats and increased gastric mucus in normal animals both in the absence and in the presence of indomethacin treatment.

In other words, IdB 1027 possessed a promising antiulcer activity, probably by potentiating the defensive barriers of the gastrointestinal mucosa.

Taken altogether, bilberry may be considered a functional remedy for the prevention and treatment of gastric ulcers, pending the validation of a larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) The protective effect and action mechanism of Vaccinium myrtillus L. on gastric ulcer in mice by Ogawa K1, Oyagi A, Tanaka J, Kobayashi S, Hara H. (PubMed)
(2) Antiulcer activity of an anthocyanidin from Vaccinium myrtillus by Magistretti MJ1, Conti M, Cristoni A. (PubMed)
(3) Obesity and Gastric Ulcers by Dr. Nadia B. Pietrzykowska. (OMC community)

#Curcumin Isolated from #Healthyfood #Turmeric May Be Consider A Potential Adjunctive Chemotherapy for #LungCancer

By Kyle J. Norton

The lung located near the backbone on either side of the heart is a vital organ that inhales oxygen from the air and then transports them to the bloodstream to nourish the body cells' needs and exhales carbon dioxide from the bloodstream.

Lung cancer is a chronic condition caused by the alternation of cells' DNA that starts in the cells on the surface of the inner lining of the lung tissue. The most common form of primary lung cancer is derived from epithelial cells.

According to the statistics, lung cancer is the leading cause of cancer deaths in the US. 1 in 16 people in the US will be diagnosed with lung cancer in their lifetime. Every year approximately over 220,000 people in the US are diagnosed with lung cancer this year.

Believe it or not, 60% to 65% of all new lung cancer diagnoses are among people who have never smoked or are former smokers.

Depending on the types and aggressiveness of cancer cells originated lung cancer can be classified into
* Non-small cell lung cancer
Non-small cell lung cancer is the most common type of lung cancer that usually grows and spreads methodically and predictably, including
* Squamous-cell carcinoma is often found in an outer area of the lung,

* Large-cell carcinoma is found in the center of the lung by an air tube.

* Adenocarcinoma is found in any part of the lung.

* Small cell lung cancer
Small cell lung cancer is a fast-growing type of lung cancer, that spread quickly to distant parts of the body in a relatively early stage, including
* Small cell carcinoma in which the cells are small, round, and resemble oats.

* Mixed small cell/large cell carcinoma in which a malignant tumor is found in combining of components of small cell lung carcinoma with large cell lung carcinoma.

* Combined small cell carcinoma, a malignant tumor is found by combining a component of small cell lung carcinoma with components of non-small cell lung carcinoma.

The most common symptoms of lung cancer are shortness of breath, cough up blood, pain, fluid in the chest, wheezing, and hoarseness accompanied by general symptoms shared by other types of cancer.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential compound for the treatment of lung cancer, researchers examined curcumin's (diferuloylmethane) anticancer properties.

According to the tested assays,* Curcumin can be an effective adjunct in treating solid organ tumors by activation of tumors' suppressive genes such as p53, DNA protective gene, and gene associated with cell growth and apoptosis
* Curcumin protects the lung cell integrity against the pathway associated with the pro0duction of proinflammatory cytokines.

* Curcumin stimulates the transcription factors associated with growth inhibition and apoptosis in tumor cells.

These results strongly suggested that curcumin can be adjunctive chemotherapy to augment currently available treatment protocols, that decreased side effects and toxicity without compromising therapeutic efficacy.

Dr. the lead scientists, after taking into account co and confounder wrote, " Curcumin is one such potential candidate, and this review presents an overview of the current in vitro and in vivo studies of curcumin in lung cancer"

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of lung cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin and lung cancer--a review by Mehta HJ1, Patel V, Sadikot RT. (PubMed)
(2) Curcumin and Lung Cancer: the Role of microRNAs by Lelli D1, Pedone C1, Majeed M2, Sahebkar A. (PubMed)
(3) Lung Cancer by Kyle J. Norton

#Healthyfood #Blackbeans Are Associated with A Reduced Risk of #ColonCancer, According to Studies

By Kyle J. Norton

Black beans may have a profound effect on reducing and treatment of colon cancer, some scientists suggested.
The colon also known as the large bowel or large intestine, is part of the digestive system in our body.

Colon cancer is a chronic condition caused by cell growth irregularly and disorderly in the colon due to the alternation of DNA.

Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. At this stage, patients may not experience any symptoms.

After penetrating deeper into the colon layer, the cancer cells may travel a distance away to infect other healthy tissue and organs through fluids and blood circulation.

At this stage, the increased size of the tumor may suppress the nearby tissue, organs, or nerve cells causing localized symptoms and severe pain.

The most common colon cancer metastasis is in the lungs and liver.

According to epidemiological studies, the most common risk factors of colon cancer are older

age, ethnicity, personal and family history of colorectal cancer or polyps, and inflammatory intestinal conditions.

Particularly, people who follow a low-fiber, high-fat diet or have a sedentary lifestyle. are associated with a substantial risk for the onset of the disease.


Dr. Y J Cong, the lead author in the concerns of the sedentary behavior in risk of colon cancer in modern society, launched an investigation to examine the association of sedentary behavior with colon and rectal cancer.


The search of the databases of PubMed, Embase, and Google Scholar databases up to May 2013 to identify cohort and case-control studies that evaluated the association between sedentary behavior and colon or rectal cancer identified 23 studies with 63 reports including 4 324 462 participants.

After assessing the results of all the studies, the doctor team wrote. "Sedentary behavior is associated with an increased risk of colon cancer. Subgroup analyses suggest a positive association between sedentary behavior and risk of rectal cancer in cohort studies".

Black bean is a Small roughly ovoid legume with glossy black shells, genus Phaseolus, belonging to the family Fabaceae.

The bean can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was the first domesticated growth in South America.

The major chemical compounds of black beans include anthocyanin, (-)-epicatechin, delphinidin, petunidin, flavonols, and malvidin.

In finding a natural whole food for the treatment of colon cancer, researchers at the Tecnológico de Monterrey-Campus Monterrey conducted an investigation to examine the black bean antioxidant capacity and antiproliferative activity against cancer cell lines.

Flavonoids extracted from seed coats exerted a potential effect against colon cancer cell line'

The extracts obtained from seed coats after 3 and 5 germination days inhibited all cancer cell line proliferation, including the tested colon cancer with no cytotoxicity against control cells.

Further analysis also suggested that flavonols and group B saponins isolated from the seed coat were more related to hepatic and colon cancers.

These results indicated that not all chemical compounds found in black beans have a potential effect in the inhibition of colon cancer. However, the intake of the black bean as a whole food may have significant effects in reducing the risk of colon cancer.

Additionally, in finding evidence to suggest an inverse relationship between bean consumption and colon cancer, researchers at the Food Science program at Michigan State University conducted a study to determine whether consumption of black beans and/or navy beans would reduce colon carcinogenesis in rats.

Selected rat groups were fed a modified AIN-93G diet (control) or diets containing 75% black beans or 75% navy beans for 4 wk, and then colon cancer was initiated by the administration of two injections of azoxymethane 1 wk apart.

At 31 wk after the second injection, the incidence of colon adenocarcinomas was significantly lower in rats fed the black bean (9%) than in rats fed the control diet (36%).

Total tumor multiplicity was also significantly lower in rats fed the black bean diet than in rats fed the control diet.

After taking into account co and confounders, Dr. Hangen L, the lead author said, "The 44-75% reduction in colon carcinogenesis in rats fed beans was attributed to 1) more controlled appetites, leading to significantly less body fat, and 2) much greater concentrations of butyrate in the distal colon".

These results suggested black beans only have a potential effect in lowering the risk of colon cancer. but also stop cell multiplicity in the case of colon cancer.

However, further data collection large example size and multi-center studies performed with human consumption of whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of black bean anti-colon cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.



References
(1) Differential accumulation of polyphenolics in black bean genotypes grown in four environments.
Marles MA, Balasubramanian P, Bett KE. (PubMed)
(2) Evaluation of the antioxidant and antiproliferative activities of extracted saponins and flavonols from germinated black beans (Phaseolus vulgaris L.).
Guajardo-Flores D, Serna-Saldívar SO, Gutiérrez-Uribe JA(PubMed)
(3) Consumption of black beans and navy beans (Phaseolus vulgaris) reduced azoxymethane-induced colon cancer in rats. by Hangen L, Bennink MR. (PubMed)
(4) Association of sedentary behavior with colon and rectal cancer: a meta-analysis of observational studies by bY J Cong,1 Y Gan,1 HL Sun,1 J Deng,1 S Y Cao,1 X Xu,1,2 and Z X Lu. (PubMed)

#Healthyfood #Greentea In Inhibtion of the #ProinflammatryCytokines Against Symptoms and Progression of #PolymyalgiaArthritis (Rheumatica)

By Kyle J. Norton

Green tea may have a therapeutic and positive effect in reducing symptoms, risk, progression, and treatment of polymyalgia arthritis (rheumatism), some scientists suggested.

Green tea is a precious drink that processed a number of health benefits and is known to almost everyone in Asia and the Western world.

Polymyalgia Rheumatica is an inflammatory disease with muscle pain and stiffness, especially in the shoulders, affecting mostly older adults beyond the age of 65.

In an animal study of inflammatory diseases induced by injection of LPS, the application of green tea bioactive polyphenols EGCG improved the antioxidant status of the host and decreased the production of inflammatory factors, including PMR through its antioxidant properties.

Further analysis suggested that application of EGCG reduced symptoms of inflammation such as pain, tension, stiffness, and swelling of the infectious site without affecting the function of the immune system in protection against microorganisms invasion through inhibiting over-expression of tumor necrosis alpha(TNF-α) involved in the systematic inflammatory response to the acute phase of infection.

The bioactive compound also inhibited reactive oxygen species (ROS) in stimulated production of inflammatory cytokines through free radicals chain reactions in facilitated inflammation and precipitated skeletal muscle dysfunction and degradation by infiltrating immune cells to induce direct injury to muscle tissue or activating catabolic signaling.

In fact, the overproduction of ROS increased the continuous expression of mitochondria, NAD(P)H oxidases, xanthine oxidoreductases, and nitric oxide synthases causing an imbalance of the free radicals and antioxidant ratio, in orchestrated oxidative stress to muscle cells.

The further evaluation suggested that green tea EGCG reduced the expression of interleukin 6 (IL-6), with function in response to infections and tissue injuries.

Long-term overproduction of IL 6 due to the duo factors as a pro and anti-inflammatory protein may increase high-level concentrations of serum amyloid A (SAA), which has been found to induce serious complications of several chronic inflammatory diseases through generated and deposited amyloid A amyloidosis into the extracellular space in an abnormal, insoluble, fibrillar form,

Moreover, EGCG also attenuated levels of nuclear factor kappa B (NF-κB) in regulated innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses through activation of tumor necrosis factor-alpha (TNF-α) in promoted muscle wasting, leading to muscle atrophy in the induction of pain and stiffness and swelling.

Importantly, the application of green tea EGCG enhanced the natural antioxidant enzymes in the host such as glutathione, an antioxidant enzyme produced naturally found in every cell and tissue of the body.

These actions together with antioxidants initiated by injection of green tea EGCG stimulated cell regeneration, preserved the muscle cells and tissues, and prevented muscle tension to precipitate polymyalgia arthritis.

A deficiency of glutathione levels was found to associate with the early development of Polymyalgia Arthritis in facilitated symptoms of pain, stiffness, achiness, fatigue, and fever.

Differentiation of the above was supported by conventional medicine corticosteroids, a powerful anti-inflammatory drug with the function to target pro-inflammation cytokines in relieving stiffness and pain in patients with polymyalgia arthritis.

Taken together, Green tea and its bioactive polyphenols EGCG may be considered a functional food for alleviating symptoms, risk, progression, and treatment of polymyalgia arthritis (Rheumatica). However, ingestion of green tea supplements should be taken with extreme care as acute liver toxicity has been reported in several medical literature.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Epigallocatechin-3-gallate attenuates lipopolysaccharide-induced mastitis in rats via suppressing MAPK-mediated inflammatory responses and oxidative stress by Chen J1, Xu J1, Li J1, Du L1, Chen T2, Liu P1, Peng S1, Wang M1, Song H3.(PubMed)
(2) [Anti-inflammatory effects of tea-flavonoids].[Article in German] by Hoensch H1, Oertel R.(PubMed)
(3) Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]. by Singh R1, Akhtar N, Haqqi TM.(PubMed)

#Healthfood #Tomatoes Inhibit #ProinflammatoryCytokines Associated with Aβ-induced learning and Memory Deficits in Neurological Disorders, Researchers Say

By Kyle J. Norton

Neurological disorders are class of diseases associated with the brain, the spinal cord including the nerves that connect them.

The most common diseases of the neurological disorder are dementia, including ALS. PD, Alzheimer's disease, birth defects of the brain and spinal cord, brain injury, and tumors.

Back pain associated with related nerve damage is one of the common complaints in the US that send many patients to seek help from their doctor. Believe it or not, 80% of the US population will experience back pain at some time in their lives.


There is no single cause of neuro-dysfunction. Lifestyle, infections, genetics, and nutrition-related disease, environment, and physical injuries have been found to be some major prevalent factors that induce the onset of neurological abnormalities.

Furthermore, neurological disorders have been found to facilitate psychological symptoms such as anxiety and depression and physical symptoms, depending totally on the neurons affected, including partial or complete paralysis muscle weakness seen in post-stroke patients, difficulty reading and writing, and poor cognitive abilities such as patients with dementia.

According to the American Addiction Center, if you experience some of the below symptoms persistently, inclduing headaches, blurry vision, persistent fatigue, changes in behavior, numbness in the legs or arms, changes in coordination or balance weakness, slurred speech and tremors, you should seek help from the professionals immediately, as these may be the first signs of neurological disorders.

Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to find a natural ingredient for the treatment of neurological inflammatory disease, researchers examined phytochemical lycopene isolated from tomatoes against experimental Parkinson's disease (PD).

The study included PD mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oral administration of different doses (5, 10, and 20 mg/kg/day).

All doses showed a strong effect in protecting against MPTP-induced depletion of striatal dopamine (DA) and its metabolites in a dose-dependent manner.

Application of all doses also attenuated MPTP-induced oxidative stress and motor abnormalities in mice treated with MPTP.

Furthermore, according to the western blot assay, lycopene protected the neurons against MPTP-induced apoptosis through its antioxidant and antiapoptotic properties.

In other words, lycopene in different doses exerted a PD protective activity by restoring the neurochemicals, and neuron apoptosis caused by overexpression of free radicals.

Based on the findings, researchers said, " lycopene reverses neurochemical deficits, oxidative stress, apoptosis and physiological abnormalities in PD mice and offers promise strategy in the treatment of this neurodegenerative disease".

Moreover, in Alzheimer's disease (AD), associated with neuroinflammation characterized by glial activation and release of proinflammatory mediators, researchers examined the efficacy of lycopene against β-Amyloid1-42 (Aβ1-42)-induced learning and memory impairment in an animal model.

In selected induced Aβ1-42 bilaterally followed by treatment with lycopene or rivastigmine for 14 days, lycopene remediated Aβ-induced learning and memory deficits in a dose-dependent manner.

Additionally, lycopene treated group showed to ameliorate the side effects of Aβ1-42-induced mitochondrial dysfunction along with a surge of proinflammatory cytokines (TNF-α, TGF-β, and IL-1β) and protein associated with inflammatory signaling and neuron apoptosis.

Dr. Sachdeva AK, the lead scientist after taking other factors into account, wrote, "The amelioration of Aβ1-42-induced spatial learning and memory impairment by lycopene could be linked, at least in part, to the inhibition of NF-κB activity and the down-regulation of expression of neuroinflammatory cytokines, suggesting that lycopene may be a potential candidate for AD treatment".

Taken altogether, tomatoes processed with the abundantly bioactive ingredient lycopene may be considered supplements for the prevention and treatment of angiotensin caused by oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Neuroprotective effect of lycopene against MPTP induced experimental Parkinson's disease in mice by Prema A1, Janakiraman U1, Manivasagam T2, Thenmozhi AJ. (PubMed)
(2) Lycopene abrogates Aβ(1-42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer's disease by Sachdeva AK1, Chopra K. (PubMed)
(3) Neurological Problem Symptoms, Causes, and Effects by the American Addiction Center