By Kyle J. Norton
Black beans may have a profound effect on reducing and treatment of colon cancer, some scientists suggested.
The colon also known as the large bowel or large intestine, is part of the digestive system in our body.
Colon cancer is a chronic condition caused by cell growth irregularly and disorderly in the colon due to the alternation of DNA.
Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. At this stage, patients may not experience any symptoms.
After penetrating deeper into the colon layer, the cancer cells may travel a distance away to infect other healthy tissue and organs through fluids and blood circulation.
At this stage, the increased size of the tumor may suppress the nearby tissue, organs, or nerve cells causing localized symptoms and severe pain.
The most common colon cancer metastasis is in the lungs and liver.
According to epidemiological studies, the most common risk factors of colon cancer are older
age, ethnicity, personal and family history of colorectal cancer or polyps, and inflammatory intestinal conditions.
Particularly, people who follow a low-fiber, high-fat diet or have a sedentary lifestyle. are associated with a substantial risk for the onset of the disease.
Dr. Y J Cong, the lead author in the concerns of the sedentary behavior in risk of colon cancer in modern society, launched an investigation to examine the association of sedentary behavior with colon and rectal cancer.
The search of the databases of PubMed, Embase, and Google Scholar databases up to May 2013 to identify cohort and case-control studies that evaluated the association between sedentary behavior and colon or rectal cancer identified 23 studies with 63 reports including 4 324 462 participants.
After assessing the results of all the studies, the doctor team wrote. "Sedentary behavior is associated with an increased risk of colon cancer. Subgroup analyses suggest a positive association between sedentary behavior and risk of rectal cancer in cohort studies".
Black bean is a Small roughly ovoid legume with glossy black shells, genus Phaseolus, belonging to the family Fabaceae.
The bean can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was the first domesticated growth in South America.
The major chemical compounds of black beans include anthocyanin, (-)-epicatechin, delphinidin, petunidin, flavonols, and malvidin.
In finding a natural whole food for the treatment of colon cancer, researchers at the Tecnológico de Monterrey-Campus Monterrey conducted an investigation to examine the black bean antioxidant capacity and antiproliferative activity against cancer cell lines.
Flavonoids extracted from seed coats exerted a potential effect against colon cancer cell line'
The extracts obtained from seed coats after 3 and 5 germination days inhibited all cancer cell line proliferation, including the tested colon cancer with no cytotoxicity against control cells.
Further analysis also suggested that flavonols and group B saponins isolated from the seed coat were more related to hepatic and colon cancers.
These results indicated that not all chemical compounds found in black beans have a potential effect in the inhibition of colon cancer. However, the intake of the black bean as a whole food may have significant effects in reducing the risk of colon cancer.
Additionally, in finding evidence to suggest an inverse relationship between bean consumption and colon cancer, researchers at the Food Science program at Michigan State University conducted a study to determine whether consumption of black beans and/or navy beans would reduce colon carcinogenesis in rats.
Selected rat groups were fed a modified AIN-93G diet (control) or diets containing 75% black beans or 75% navy beans for 4 wk, and then colon cancer was initiated by the administration of two injections of azoxymethane 1 wk apart.
At 31 wk after the second injection, the incidence of colon adenocarcinomas was significantly lower in rats fed the black bean (9%) than in rats fed the control diet (36%).
Total tumor multiplicity was also significantly lower in rats fed the black bean diet than in rats fed the control diet.
After taking into account co and confounders, Dr. Hangen L, the lead author said, "The 44-75% reduction in colon carcinogenesis in rats fed beans was attributed to 1) more controlled appetites, leading to significantly less body fat, and 2) much greater concentrations of butyrate in the distal colon".
These results suggested black beans only have a potential effect in lowering the risk of colon cancer. but also stop cell multiplicity in the case of colon cancer.
However, further data collection large example size and multi-center studies performed with human consumption of whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of black bean anti-colon cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Differential accumulation of polyphenolics in black bean genotypes grown in four environments.
Marles MA, Balasubramanian P, Bett KE. (PubMed)
(2) Evaluation of the antioxidant and antiproliferative activities of extracted saponins and flavonols from germinated black beans (Phaseolus vulgaris L.).
Guajardo-Flores D, Serna-Saldívar SO, Gutiérrez-Uribe JA(PubMed)
(3) Consumption of black beans and navy beans (Phaseolus vulgaris) reduced azoxymethane-induced colon cancer in rats. by Hangen L, Bennink MR. (PubMed)
(4) Association of sedentary behavior with colon and rectal cancer: a meta-analysis of observational studies by bY J Cong,1 Y Gan,1 HL Sun,1 J Deng,1 S Y Cao,1 X Xu,1,2 and Z X Lu. (PubMed)
Monday, 12 June 2023
#Healthyfood #Greentea In Inhibtion of the #ProinflammatryCytokines Against Symptoms and Progression of #PolymyalgiaArthritis (Rheumatica)
By Kyle J. Norton
Green tea may have a therapeutic and positive effect in reducing symptoms, risk, progression, and treatment of polymyalgia arthritis (rheumatism), some scientists suggested.
Green tea is a precious drink that processed a number of health benefits and is known to almost everyone in Asia and the Western world.
Polymyalgia Rheumatica is an inflammatory disease with muscle pain and stiffness, especially in the shoulders, affecting mostly older adults beyond the age of 65.
In an animal study of inflammatory diseases induced by injection of LPS, the application of green tea bioactive polyphenols EGCG improved the antioxidant status of the host and decreased the production of inflammatory factors, including PMR through its antioxidant properties.
Further analysis suggested that application of EGCG reduced symptoms of inflammation such as pain, tension, stiffness, and swelling of the infectious site without affecting the function of the immune system in protection against microorganisms invasion through inhibiting over-expression of tumor necrosis alpha(TNF-α) involved in the systematic inflammatory response to the acute phase of infection.
The bioactive compound also inhibited reactive oxygen species (ROS) in stimulated production of inflammatory cytokines through free radicals chain reactions in facilitated inflammation and precipitated skeletal muscle dysfunction and degradation by infiltrating immune cells to induce direct injury to muscle tissue or activating catabolic signaling.
In fact, the overproduction of ROS increased the continuous expression of mitochondria, NAD(P)H oxidases, xanthine oxidoreductases, and nitric oxide synthases causing an imbalance of the free radicals and antioxidant ratio, in orchestrated oxidative stress to muscle cells.
The further evaluation suggested that green tea EGCG reduced the expression of interleukin 6 (IL-6), with function in response to infections and tissue injuries.
Long-term overproduction of IL 6 due to the duo factors as a pro and anti-inflammatory protein may increase high-level concentrations of serum amyloid A (SAA), which has been found to induce serious complications of several chronic inflammatory diseases through generated and deposited amyloid A amyloidosis into the extracellular space in an abnormal, insoluble, fibrillar form,
Moreover, EGCG also attenuated levels of nuclear factor kappa B (NF-κB) in regulated innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses through activation of tumor necrosis factor-alpha (TNF-α) in promoted muscle wasting, leading to muscle atrophy in the induction of pain and stiffness and swelling.
Importantly, the application of green tea EGCG enhanced the natural antioxidant enzymes in the host such as glutathione, an antioxidant enzyme produced naturally found in every cell and tissue of the body.
These actions together with antioxidants initiated by injection of green tea EGCG stimulated cell regeneration, preserved the muscle cells and tissues, and prevented muscle tension to precipitate polymyalgia arthritis.
A deficiency of glutathione levels was found to associate with the early development of Polymyalgia Arthritis in facilitated symptoms of pain, stiffness, achiness, fatigue, and fever.
Differentiation of the above was supported by conventional medicine corticosteroids, a powerful anti-inflammatory drug with the function to target pro-inflammation cytokines in relieving stiffness and pain in patients with polymyalgia arthritis.
Taken together, Green tea and its bioactive polyphenols EGCG may be considered a functional food for alleviating symptoms, risk, progression, and treatment of polymyalgia arthritis (Rheumatica). However, ingestion of green tea supplements should be taken with extreme care as acute liver toxicity has been reported in several medical literature.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate attenuates lipopolysaccharide-induced mastitis in rats via suppressing MAPK-mediated inflammatory responses and oxidative stress by Chen J1, Xu J1, Li J1, Du L1, Chen T2, Liu P1, Peng S1, Wang M1, Song H3.(PubMed)
(2) [Anti-inflammatory effects of tea-flavonoids].[Article in German] by Hoensch H1, Oertel R.(PubMed)
(3) Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]. by Singh R1, Akhtar N, Haqqi TM.(PubMed)
Green tea may have a therapeutic and positive effect in reducing symptoms, risk, progression, and treatment of polymyalgia arthritis (rheumatism), some scientists suggested.
Green tea is a precious drink that processed a number of health benefits and is known to almost everyone in Asia and the Western world.
Polymyalgia Rheumatica is an inflammatory disease with muscle pain and stiffness, especially in the shoulders, affecting mostly older adults beyond the age of 65.
In an animal study of inflammatory diseases induced by injection of LPS, the application of green tea bioactive polyphenols EGCG improved the antioxidant status of the host and decreased the production of inflammatory factors, including PMR through its antioxidant properties.
Further analysis suggested that application of EGCG reduced symptoms of inflammation such as pain, tension, stiffness, and swelling of the infectious site without affecting the function of the immune system in protection against microorganisms invasion through inhibiting over-expression of tumor necrosis alpha(TNF-α) involved in the systematic inflammatory response to the acute phase of infection.
The bioactive compound also inhibited reactive oxygen species (ROS) in stimulated production of inflammatory cytokines through free radicals chain reactions in facilitated inflammation and precipitated skeletal muscle dysfunction and degradation by infiltrating immune cells to induce direct injury to muscle tissue or activating catabolic signaling.
In fact, the overproduction of ROS increased the continuous expression of mitochondria, NAD(P)H oxidases, xanthine oxidoreductases, and nitric oxide synthases causing an imbalance of the free radicals and antioxidant ratio, in orchestrated oxidative stress to muscle cells.
The further evaluation suggested that green tea EGCG reduced the expression of interleukin 6 (IL-6), with function in response to infections and tissue injuries.
Long-term overproduction of IL 6 due to the duo factors as a pro and anti-inflammatory protein may increase high-level concentrations of serum amyloid A (SAA), which has been found to induce serious complications of several chronic inflammatory diseases through generated and deposited amyloid A amyloidosis into the extracellular space in an abnormal, insoluble, fibrillar form,
Moreover, EGCG also attenuated levels of nuclear factor kappa B (NF-κB) in regulated innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses through activation of tumor necrosis factor-alpha (TNF-α) in promoted muscle wasting, leading to muscle atrophy in the induction of pain and stiffness and swelling.
Importantly, the application of green tea EGCG enhanced the natural antioxidant enzymes in the host such as glutathione, an antioxidant enzyme produced naturally found in every cell and tissue of the body.
These actions together with antioxidants initiated by injection of green tea EGCG stimulated cell regeneration, preserved the muscle cells and tissues, and prevented muscle tension to precipitate polymyalgia arthritis.
A deficiency of glutathione levels was found to associate with the early development of Polymyalgia Arthritis in facilitated symptoms of pain, stiffness, achiness, fatigue, and fever.
Differentiation of the above was supported by conventional medicine corticosteroids, a powerful anti-inflammatory drug with the function to target pro-inflammation cytokines in relieving stiffness and pain in patients with polymyalgia arthritis.
Taken together, Green tea and its bioactive polyphenols EGCG may be considered a functional food for alleviating symptoms, risk, progression, and treatment of polymyalgia arthritis (Rheumatica). However, ingestion of green tea supplements should be taken with extreme care as acute liver toxicity has been reported in several medical literature.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate attenuates lipopolysaccharide-induced mastitis in rats via suppressing MAPK-mediated inflammatory responses and oxidative stress by Chen J1, Xu J1, Li J1, Du L1, Chen T2, Liu P1, Peng S1, Wang M1, Song H3.(PubMed)
(2) [Anti-inflammatory effects of tea-flavonoids].[Article in German] by Hoensch H1, Oertel R.(PubMed)
(3) Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]. by Singh R1, Akhtar N, Haqqi TM.(PubMed)
#Healthfood #Tomatoes Inhibit #ProinflammatoryCytokines Associated with Aβ-induced learning and Memory Deficits in Neurological Disorders, Researchers Say
By Kyle J. Norton
Neurological disorders are class of diseases associated with the brain, the spinal cord including the nerves that connect them.
The most common diseases of the neurological disorder are dementia, including ALS. PD, Alzheimer's disease, birth defects of the brain and spinal cord, brain injury, and tumors.
Back pain associated with related nerve damage is one of the common complaints in the US that send many patients to seek help from their doctor. Believe it or not, 80% of the US population will experience back pain at some time in their lives.
There is no single cause of neuro-dysfunction. Lifestyle, infections, genetics, and nutrition-related disease, environment, and physical injuries have been found to be some major prevalent factors that induce the onset of neurological abnormalities.
Furthermore, neurological disorders have been found to facilitate psychological symptoms such as anxiety and depression and physical symptoms, depending totally on the neurons affected, including partial or complete paralysis muscle weakness seen in post-stroke patients, difficulty reading and writing, and poor cognitive abilities such as patients with dementia.
According to the American Addiction Center, if you experience some of the below symptoms persistently, inclduing headaches, blurry vision, persistent fatigue, changes in behavior, numbness in the legs or arms, changes in coordination or balance weakness, slurred speech and tremors, you should seek help from the professionals immediately, as these may be the first signs of neurological disorders.
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a natural ingredient for the treatment of neurological inflammatory disease, researchers examined phytochemical lycopene isolated from tomatoes against experimental Parkinson's disease (PD).
The study included PD mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oral administration of different doses (5, 10, and 20 mg/kg/day).
All doses showed a strong effect in protecting against MPTP-induced depletion of striatal dopamine (DA) and its metabolites in a dose-dependent manner.
Application of all doses also attenuated MPTP-induced oxidative stress and motor abnormalities in mice treated with MPTP.
Furthermore, according to the western blot assay, lycopene protected the neurons against MPTP-induced apoptosis through its antioxidant and antiapoptotic properties.
In other words, lycopene in different doses exerted a PD protective activity by restoring the neurochemicals, and neuron apoptosis caused by overexpression of free radicals.
Based on the findings, researchers said, " lycopene reverses neurochemical deficits, oxidative stress, apoptosis and physiological abnormalities in PD mice and offers promise strategy in the treatment of this neurodegenerative disease".
Moreover, in Alzheimer's disease (AD), associated with neuroinflammation characterized by glial activation and release of proinflammatory mediators, researchers examined the efficacy of lycopene against β-Amyloid1-42 (Aβ1-42)-induced learning and memory impairment in an animal model.
In selected induced Aβ1-42 bilaterally followed by treatment with lycopene or rivastigmine for 14 days, lycopene remediated Aβ-induced learning and memory deficits in a dose-dependent manner.
Additionally, lycopene treated group showed to ameliorate the side effects of Aβ1-42-induced mitochondrial dysfunction along with a surge of proinflammatory cytokines (TNF-α, TGF-β, and IL-1β) and protein associated with inflammatory signaling and neuron apoptosis.
Dr. Sachdeva AK, the lead scientist after taking other factors into account, wrote, "The amelioration of Aβ1-42-induced spatial learning and memory impairment by lycopene could be linked, at least in part, to the inhibition of NF-κB activity and the down-regulation of expression of neuroinflammatory cytokines, suggesting that lycopene may be a potential candidate for AD treatment".
Taken altogether, tomatoes processed with the abundantly bioactive ingredient lycopene may be considered supplements for the prevention and treatment of angiotensin caused by oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective effect of lycopene against MPTP induced experimental Parkinson's disease in mice by Prema A1, Janakiraman U1, Manivasagam T2, Thenmozhi AJ. (PubMed)
(2) Lycopene abrogates Aβ(1-42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer's disease by Sachdeva AK1, Chopra K. (PubMed)
(3) Neurological Problem Symptoms, Causes, and Effects by the American Addiction Center
Neurological disorders are class of diseases associated with the brain, the spinal cord including the nerves that connect them.
The most common diseases of the neurological disorder are dementia, including ALS. PD, Alzheimer's disease, birth defects of the brain and spinal cord, brain injury, and tumors.
Back pain associated with related nerve damage is one of the common complaints in the US that send many patients to seek help from their doctor. Believe it or not, 80% of the US population will experience back pain at some time in their lives.
There is no single cause of neuro-dysfunction. Lifestyle, infections, genetics, and nutrition-related disease, environment, and physical injuries have been found to be some major prevalent factors that induce the onset of neurological abnormalities.
Furthermore, neurological disorders have been found to facilitate psychological symptoms such as anxiety and depression and physical symptoms, depending totally on the neurons affected, including partial or complete paralysis muscle weakness seen in post-stroke patients, difficulty reading and writing, and poor cognitive abilities such as patients with dementia.
According to the American Addiction Center, if you experience some of the below symptoms persistently, inclduing headaches, blurry vision, persistent fatigue, changes in behavior, numbness in the legs or arms, changes in coordination or balance weakness, slurred speech and tremors, you should seek help from the professionals immediately, as these may be the first signs of neurological disorders.
Tomato is a red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a natural ingredient for the treatment of neurological inflammatory disease, researchers examined phytochemical lycopene isolated from tomatoes against experimental Parkinson's disease (PD).
The study included PD mice induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oral administration of different doses (5, 10, and 20 mg/kg/day).
All doses showed a strong effect in protecting against MPTP-induced depletion of striatal dopamine (DA) and its metabolites in a dose-dependent manner.
Application of all doses also attenuated MPTP-induced oxidative stress and motor abnormalities in mice treated with MPTP.
Furthermore, according to the western blot assay, lycopene protected the neurons against MPTP-induced apoptosis through its antioxidant and antiapoptotic properties.
In other words, lycopene in different doses exerted a PD protective activity by restoring the neurochemicals, and neuron apoptosis caused by overexpression of free radicals.
Based on the findings, researchers said, " lycopene reverses neurochemical deficits, oxidative stress, apoptosis and physiological abnormalities in PD mice and offers promise strategy in the treatment of this neurodegenerative disease".
Moreover, in Alzheimer's disease (AD), associated with neuroinflammation characterized by glial activation and release of proinflammatory mediators, researchers examined the efficacy of lycopene against β-Amyloid1-42 (Aβ1-42)-induced learning and memory impairment in an animal model.
In selected induced Aβ1-42 bilaterally followed by treatment with lycopene or rivastigmine for 14 days, lycopene remediated Aβ-induced learning and memory deficits in a dose-dependent manner.
Additionally, lycopene treated group showed to ameliorate the side effects of Aβ1-42-induced mitochondrial dysfunction along with a surge of proinflammatory cytokines (TNF-α, TGF-β, and IL-1β) and protein associated with inflammatory signaling and neuron apoptosis.
Dr. Sachdeva AK, the lead scientist after taking other factors into account, wrote, "The amelioration of Aβ1-42-induced spatial learning and memory impairment by lycopene could be linked, at least in part, to the inhibition of NF-κB activity and the down-regulation of expression of neuroinflammatory cytokines, suggesting that lycopene may be a potential candidate for AD treatment".
Taken altogether, tomatoes processed with the abundantly bioactive ingredient lycopene may be considered supplements for the prevention and treatment of angiotensin caused by oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective effect of lycopene against MPTP induced experimental Parkinson's disease in mice by Prema A1, Janakiraman U1, Manivasagam T2, Thenmozhi AJ. (PubMed)
(2) Lycopene abrogates Aβ(1-42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer's disease by Sachdeva AK1, Chopra K. (PubMed)
(3) Neurological Problem Symptoms, Causes, and Effects by the American Addiction Center
#Healthyfood #Lentils' #Lectin, May Be Considered a Target for the treatment of #CervicalCancer, Researchers Say
By Kyle J. Norton
Protein-binding lectin (including lectin isolated from lentils) may have a positive and profound effect on the treatment of cancers and be used as a new type of potential biomarker and therapeutic target in the treatment of cervical cancer, some scientists suggested.
Lentil a type of pulse and tiny legume that can be cooked quickly and rich in protein and fiber is a bushy annual plant of the genus Lens in the Fabaceae family, native to the Middle East.
Lectins are carbohydrate-binding proteins with the function to specifically interact with other carbohydrate moieties.
The investigation of the effect of protein-binding lectin for the treatment of cancers and as potential biomarkers and therapeutic targets in the treatment of cervical cancer was depending on the expression of certain mechanisms in some aspects.
In the study of the effect of Frutalin, α-D-galactose-binding lectin, isolated from Pichia pastoris and native frutalin on cervical cancer cell line HeLa measured by confocal microscopy, researchers found that Frutalin expressed a significant magnitude in the induction of cytotoxicity on cell growth and cell apoptosis in tested HeLa cell line through targeting HeLa cell's nucleus.
Additionally, in other studies to evaluate the association of specific mbl-2 alleles(mannose-binding lectin (MBL)) and susceptibility to HPV infection of 150 patients with HPV and 277 control subjects with no HPV, scientists suggested that there is a potential linking of expression of mannose-binding lectin (MBL) in high-risk HPV in the induction of cervical cancer, but patients with the mbl-2 alternative phenotypes gene represented a least significant risk for the group with HPV, even though, the frequency of high-producer mbl-2 genotypes was found higher in patients with HPV than in control.
Mannose-binding lectin (MBL), is a serum lectin with the function of signaling innate immunity in mediated phagocytosis via the lectin pathway.
Furthermore, the study to find a new type of potential biomarkers and therapeutic targets for the treatment of cervical cancer by evaluating Galectin-1, -3, and -9, the proteins bind β-galactoside sugars via lectin pathway indicated that galectin expression was found to associate to tumor cells, tumor epithelium infiltrating immune cells and stromal cells in squamous cervical cancer.
Indeed, tested tumor cells, fibroblasts, macrophages, and T cells all expressed the presence of galectins in different scores.
Galectin-1 and -9 were both expressed by tumor cells in 11% of samples, while 84% expressed galectin-3.
Moreover, the Strong galectin-1 expression by tumor cells as an independent predictor was found to associate with poor survival and correlated with increased tumor invasion compared to weak and positive tumor cell galectin-3 expression is correlated with increased and decreased tumor invasion and tumor cell expression of galectin-9 showed a trend toward improved survival.
The in-depth evaluation also found that tumor CD163+ macrophages associated with the progression and prognostication of cervical cancers were the predominant immune cell types found in expressing galectin-1, -3, and -9. More precisely, Galectin-1 and -3 were expressed by a minor population of T cells and Galectin-1 was mainly expressed by fibroblasts in the tumor stroma.
After taking into account other confounders, researchers concluded that Galectin-1 expression might be used as a marker to target more aggressive Anti-cervical cancer treatment.
Taken together, protein-binding lectins may have a potential effect on the induction of cells apoptosis and proliferation in cervical cancer
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer by Punt S1, Thijssen VL2, Vrolijk J3, de Kroon CD4, Gorter A1, Jordanova ES5.(PubMed)
(2) Mannose-binding lectin in high-risk human papillomavirus infection by Tsai CC1, Lin TM, You HL, Eng HL. (PubMed)
(3) Cytotoxic Effects of Native and Recombinant Frutalin, a Plant Galactose-Binding Lectin, on HeLa Cervical Cancer Cells by Carla Oliveira, Ana Nicolau, José A. Teixeira, and Lucília Domingues(PMC)
Protein-binding lectin (including lectin isolated from lentils) may have a positive and profound effect on the treatment of cancers and be used as a new type of potential biomarker and therapeutic target in the treatment of cervical cancer, some scientists suggested.
Lentil a type of pulse and tiny legume that can be cooked quickly and rich in protein and fiber is a bushy annual plant of the genus Lens in the Fabaceae family, native to the Middle East.
Lectins are carbohydrate-binding proteins with the function to specifically interact with other carbohydrate moieties.
The investigation of the effect of protein-binding lectin for the treatment of cancers and as potential biomarkers and therapeutic targets in the treatment of cervical cancer was depending on the expression of certain mechanisms in some aspects.
In the study of the effect of Frutalin, α-D-galactose-binding lectin, isolated from Pichia pastoris and native frutalin on cervical cancer cell line HeLa measured by confocal microscopy, researchers found that Frutalin expressed a significant magnitude in the induction of cytotoxicity on cell growth and cell apoptosis in tested HeLa cell line through targeting HeLa cell's nucleus.
Additionally, in other studies to evaluate the association of specific mbl-2 alleles(mannose-binding lectin (MBL)) and susceptibility to HPV infection of 150 patients with HPV and 277 control subjects with no HPV, scientists suggested that there is a potential linking of expression of mannose-binding lectin (MBL) in high-risk HPV in the induction of cervical cancer, but patients with the mbl-2 alternative phenotypes gene represented a least significant risk for the group with HPV, even though, the frequency of high-producer mbl-2 genotypes was found higher in patients with HPV than in control.
Mannose-binding lectin (MBL), is a serum lectin with the function of signaling innate immunity in mediated phagocytosis via the lectin pathway.
Furthermore, the study to find a new type of potential biomarkers and therapeutic targets for the treatment of cervical cancer by evaluating Galectin-1, -3, and -9, the proteins bind β-galactoside sugars via lectin pathway indicated that galectin expression was found to associate to tumor cells, tumor epithelium infiltrating immune cells and stromal cells in squamous cervical cancer.
Indeed, tested tumor cells, fibroblasts, macrophages, and T cells all expressed the presence of galectins in different scores.
Galectin-1 and -9 were both expressed by tumor cells in 11% of samples, while 84% expressed galectin-3.
Moreover, the Strong galectin-1 expression by tumor cells as an independent predictor was found to associate with poor survival and correlated with increased tumor invasion compared to weak and positive tumor cell galectin-3 expression is correlated with increased and decreased tumor invasion and tumor cell expression of galectin-9 showed a trend toward improved survival.
The in-depth evaluation also found that tumor CD163+ macrophages associated with the progression and prognostication of cervical cancers were the predominant immune cell types found in expressing galectin-1, -3, and -9. More precisely, Galectin-1 and -3 were expressed by a minor population of T cells and Galectin-1 was mainly expressed by fibroblasts in the tumor stroma.
After taking into account other confounders, researchers concluded that Galectin-1 expression might be used as a marker to target more aggressive Anti-cervical cancer treatment.
Taken together, protein-binding lectins may have a potential effect on the induction of cells apoptosis and proliferation in cervical cancer
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer by Punt S1, Thijssen VL2, Vrolijk J3, de Kroon CD4, Gorter A1, Jordanova ES5.(PubMed)
(2) Mannose-binding lectin in high-risk human papillomavirus infection by Tsai CC1, Lin TM, You HL, Eng HL. (PubMed)
(3) Cytotoxic Effects of Native and Recombinant Frutalin, a Plant Galactose-Binding Lectin, on HeLa Cervical Cancer Cells by Carla Oliveira, Ana Nicolau, José A. Teixeira, and Lucília Domingues(PMC)
#Healthyfood #Onions are Inversely Associated with the Risk of #StomachCancer, Scientists Show
By Kyle J. Norton
Cancer is a class of chronic diseases associated with irregular cell growth in the tissues of the affected organ.
The stomach located between the esophagus and the small intestine is a muscular, hollow, and important organ of the digestive tract.
Stomach cancer is a medical condition characterized by abnormal growth of the mucus-producing cells of the inside lining of the stomach.
Depending on the location of the cancer that starts the malignancy, stomach cancer can be classified into
* Adenocarcinoma arose from the glands in the mucosa, including
** Superficial spreading
It is an early stage of cancer and tends to be less aggressive.
** Polyploid
Cancer grows in a pattern like a polyp and is less aggressive.
** Infiltrating
If cancer grows in infiltrating pattern into the stomach wall and is more aggressive.
** Linitis plastica
Cancer grows diffusivity throughout the whole wall of the stomach.
Adenocarcinoma is the most common type of stomach cancer.
* Lymphomas
Cancer of the lymphocytes originating from the stomach behaves much like lymphomas of the other parts of the body but adenocarcinoma
* Sarcomas
The cancer originated from the connected tissue of the stomach and behaves much like sarcomas of the other parts of the body but adenocarcinoma.
Most patients with stomach cancer in the early stage are asymptomatic. However, at the later stage, patients may experience symptoms of pain and/or discomfort in the stomach area, mild ache in the upper part of the body, difficulty swallowing, feeling full or bloated after a small mealy, and vomiting blood or having blood in the stool accompanied by general symptoms shared by other types of cancer, including unintentional weight loss, loss of energy, tiredness, nausea, and vomiting and loss of appetite.
If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
In finding a potential compound for the treatment of stomach cancer, researchers examined the chemopreventive effects of Allium vegetables (onions, garlic, shallots, leeks, chives, and so forth) on gastric cancer risk.
The study includes the research of MEDLINE studies of Allium vegetable consumption and gastric cancer published in any language, from January 1, 1966, to September 1, 2010.
19 case-control and 2 cohort studies, of 543,220 subjects. were selected in the analysis. Onion and other allium vegetable consumption in large amounts reduced the risk for gastric cancer with an odds ratio of 0.54 in the comparison of the highest and lowest consumption groups.
More precisely, an increment of 20 g/day of Allium vegetables consumed (approximately the average weight of 1 garlic bulb) showed a summary odds ratio of 0.91 based on case-control studies from the dose-response meta-analysis.
These results strongly suggested that regular consumption of onion has an inverse association with the risk of stomach cancer in a dose-dependent manner.
In other words, the risk of stomach cancer was reduced proportionally to the amount of onion intake regularly.
Taken altogether, onion used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of stomach cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Stomach Cancer/Gastric Cancer by Kyle J. Norton
Cancer is a class of chronic diseases associated with irregular cell growth in the tissues of the affected organ.
The stomach located between the esophagus and the small intestine is a muscular, hollow, and important organ of the digestive tract.
Stomach cancer is a medical condition characterized by abnormal growth of the mucus-producing cells of the inside lining of the stomach.
Depending on the location of the cancer that starts the malignancy, stomach cancer can be classified into
* Adenocarcinoma arose from the glands in the mucosa, including
** Superficial spreading
It is an early stage of cancer and tends to be less aggressive.
** Polyploid
Cancer grows in a pattern like a polyp and is less aggressive.
** Infiltrating
If cancer grows in infiltrating pattern into the stomach wall and is more aggressive.
** Linitis plastica
Cancer grows diffusivity throughout the whole wall of the stomach.
Adenocarcinoma is the most common type of stomach cancer.
* Lymphomas
Cancer of the lymphocytes originating from the stomach behaves much like lymphomas of the other parts of the body but adenocarcinoma
* Sarcomas
The cancer originated from the connected tissue of the stomach and behaves much like sarcomas of the other parts of the body but adenocarcinoma.
Most patients with stomach cancer in the early stage are asymptomatic. However, at the later stage, patients may experience symptoms of pain and/or discomfort in the stomach area, mild ache in the upper part of the body, difficulty swallowing, feeling full or bloated after a small mealy, and vomiting blood or having blood in the stool accompanied by general symptoms shared by other types of cancer, including unintentional weight loss, loss of energy, tiredness, nausea, and vomiting and loss of appetite.
If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
In finding a potential compound for the treatment of stomach cancer, researchers examined the chemopreventive effects of Allium vegetables (onions, garlic, shallots, leeks, chives, and so forth) on gastric cancer risk.
The study includes the research of MEDLINE studies of Allium vegetable consumption and gastric cancer published in any language, from January 1, 1966, to September 1, 2010.
19 case-control and 2 cohort studies, of 543,220 subjects. were selected in the analysis. Onion and other allium vegetable consumption in large amounts reduced the risk for gastric cancer with an odds ratio of 0.54 in the comparison of the highest and lowest consumption groups.
More precisely, an increment of 20 g/day of Allium vegetables consumed (approximately the average weight of 1 garlic bulb) showed a summary odds ratio of 0.91 based on case-control studies from the dose-response meta-analysis.
These results strongly suggested that regular consumption of onion has an inverse association with the risk of stomach cancer in a dose-dependent manner.
In other words, the risk of stomach cancer was reduced proportionally to the amount of onion intake regularly.
Taken altogether, onion used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of stomach cancer, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Stomach Cancer/Gastric Cancer by Kyle J. Norton
#NavyBean Promotes the Healthy Gut Bacterial Metabolism Through its #Prebiotic and #Probiotic Activities, Researchers Say
By Kyle J. Norton
Gut microbiota is a community of microbes living in the gastrointestinal tract, including at least 1000 different species of known bacteria with more than 3 million genes.
Normally, the ratio of good and bad microbes in the gut is balanced. However, people who have a psychological condition such as anxiety, and depression, and are under constant stress and long-term use of antibiotics, particularly your diet may have a negative impact on the ratio.
In other words, the risk factors that alter the ratio of the microbes in the gut may lead to inflammation, oxidative stress, and blood sugar imbalances.
The impact of gut microbes can also have a strong influence on what the human host is able to extract from its diet, both nutritionally and energetically.
Epidemiological studies suggested overweight and obese people show dysbiosis characterized by a lower diversity. In other words, imbalanced gut microbiota dysbiosis promotes diet-induced obesity and metabolic complications.
Some researchers suggested that we can optimize our health by manipulating the gut microbiota through diet by increasing the intake of prebiotic and probiotic foods.
However, the benefits may totally depend on their effect on the resident community which is different individually.
Dr. Hall A, the lead scientist in the study of microbial metabolism in the mammalian gut, wrote, "Microbial dysbiosis, however, has been implicated in a number of human disorders, including obesity and inflammation. This dichotomy highlights the need to understand the factors that determine the composition and metabolic output of our resident and transient microbes".
And, " Throughout the human lifespan, we know that diet plays a major role in shaping gut microbial communities, as well as directing the types and amounts of metabolites produced. Understanding the factors that affect microbial metabolic output within the host may help identify the roles of microbes in health, as well as new targets for treatment in disease".
The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.
In finding a natural compound for the improvement of gut microbiota, researchers examined the effects of heat-stabilized rice bran (SRB) and cooked navy bean powder (NBP) phytochemicals on colonic microbiota and intestinal health.
The experiment included a total of 29 overweight/obese volunteers with a prior history of colorectal cancer who consumed a study-provided meal and snack daily including eating SRB (30 g/day) or cooked navy bean powder (35 g/day) on gut microbiota and metabolites for 28 days.
Based on the tested assays,* SRB or NBP showed increased gut bacterial diversity and altered gut microbial composition at 28 days compared to baseline in favor of the "good" bacteria.
* Supplementation with SRB or NBP increased total dietary fiber intake similarly, compared to the decrease in rice bran intake.
* More precisely, the Firmicutes: Bacteroidetes ratio is increased and SCFA (propionate and acetate) associated with chronic inflammatory disease in the stool is decreased after 14 days but not at 28 days.
The results strongly suggested that the efficacy of cooked navy bean in the re-balanced the gut microbiomes in favor of the good bacteria may be attributed to fiber contents in the interaction with
phytochemicals in the bean.
Dr. Sheflin AM, the lead scientist said, " modulation of gut microbiota and fermentation byproducts by SRB and suggest that foods with similar ability to increase dietary fiber intake may not have equal effects on gut microbiota and microbial metabolism".
Taken altogether, the cooked-navy bean may be considered a remedy for the improvement of gut microbiota, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary supplementation with rice bran or navy bean alters gut bacterial metabolism in colorectal cancer survivors by Sheflin AM1, Borresen EC2, Kirkwood JS3, Boot CM4, Whitney AK1, Lu S1, Brown RJ5, Broeckling CD3, Ryan EP2, Weir TL. (PubMed)
(2) Microbial Metabolism in the Mammalian Gut: Molecular Mechanisms and Clinical Implications.
Hall A, and Versalovic J. (PubMed)
Gut microbiota is a community of microbes living in the gastrointestinal tract, including at least 1000 different species of known bacteria with more than 3 million genes.
Normally, the ratio of good and bad microbes in the gut is balanced. However, people who have a psychological condition such as anxiety, and depression, and are under constant stress and long-term use of antibiotics, particularly your diet may have a negative impact on the ratio.
In other words, the risk factors that alter the ratio of the microbes in the gut may lead to inflammation, oxidative stress, and blood sugar imbalances.
The impact of gut microbes can also have a strong influence on what the human host is able to extract from its diet, both nutritionally and energetically.
Epidemiological studies suggested overweight and obese people show dysbiosis characterized by a lower diversity. In other words, imbalanced gut microbiota dysbiosis promotes diet-induced obesity and metabolic complications.
Some researchers suggested that we can optimize our health by manipulating the gut microbiota through diet by increasing the intake of prebiotic and probiotic foods.
However, the benefits may totally depend on their effect on the resident community which is different individually.
Dr. Hall A, the lead scientist in the study of microbial metabolism in the mammalian gut, wrote, "Microbial dysbiosis, however, has been implicated in a number of human disorders, including obesity and inflammation. This dichotomy highlights the need to understand the factors that determine the composition and metabolic output of our resident and transient microbes".
And, " Throughout the human lifespan, we know that diet plays a major role in shaping gut microbial communities, as well as directing the types and amounts of metabolites produced. Understanding the factors that affect microbial metabolic output within the host may help identify the roles of microbes in health, as well as new targets for treatment in disease".
The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.
In finding a natural compound for the improvement of gut microbiota, researchers examined the effects of heat-stabilized rice bran (SRB) and cooked navy bean powder (NBP) phytochemicals on colonic microbiota and intestinal health.
The experiment included a total of 29 overweight/obese volunteers with a prior history of colorectal cancer who consumed a study-provided meal and snack daily including eating SRB (30 g/day) or cooked navy bean powder (35 g/day) on gut microbiota and metabolites for 28 days.
Based on the tested assays,* SRB or NBP showed increased gut bacterial diversity and altered gut microbial composition at 28 days compared to baseline in favor of the "good" bacteria.
* Supplementation with SRB or NBP increased total dietary fiber intake similarly, compared to the decrease in rice bran intake.
* More precisely, the Firmicutes: Bacteroidetes ratio is increased and SCFA (propionate and acetate) associated with chronic inflammatory disease in the stool is decreased after 14 days but not at 28 days.
The results strongly suggested that the efficacy of cooked navy bean in the re-balanced the gut microbiomes in favor of the good bacteria may be attributed to fiber contents in the interaction with
phytochemicals in the bean.
Dr. Sheflin AM, the lead scientist said, " modulation of gut microbiota and fermentation byproducts by SRB and suggest that foods with similar ability to increase dietary fiber intake may not have equal effects on gut microbiota and microbial metabolism".
Taken altogether, the cooked-navy bean may be considered a remedy for the improvement of gut microbiota, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary supplementation with rice bran or navy bean alters gut bacterial metabolism in colorectal cancer survivors by Sheflin AM1, Borresen EC2, Kirkwood JS3, Boot CM4, Whitney AK1, Lu S1, Brown RJ5, Broeckling CD3, Ryan EP2, Weir TL. (PubMed)
(2) Microbial Metabolism in the Mammalian Gut: Molecular Mechanisms and Clinical Implications.
Hall A, and Versalovic J. (PubMed)
#Antioxidant Quercetin Found in #GreenTea inhibits the ProinflammatoryCytokies Against the Risk of #IntestinalIschemia
By Kyle J. Norton
Green tea may have a therapeutic and positive effect in reduced risk and treatment of intestinal ischemia, some scientists suggested.
Intestinal ischemia is a serious medical condition characterized by reduced blood flow to the
intestines.
In the evaluated 3 groups of male rats randomly assigned to Group I (ischemia-reperfusion, I/R) underwent I/R of the intestine (30 min of ischemia followed by 1 h of reperfusion). Group II (green tea + I/R) was given green tea for 2 wk before inducing I/R. In Group III (control) with sham I/R, researchers found that the injection of the green tea group showed an impressive restoration of intestinal mucosa compared to the ischemia-reperfusion (I/R) group.
In observation of cellular antioxidant profile (superoxide dismutase and catalase), the green tea group expressed a significant improvement of antioxidants similar to those of group III and in compared to group II.
The expressions of cellular proliferation markers (proliferating cell nuclear antigen and Ki-67) in regulated intestinal cell division and proliferation were also increased by green tea application.
The above illustration indicated that long term intake of green tea injection may exhibit strong protection against the intestinal mucosa from injury.
Further differentiation of the effect of Quercetin, the bioactive substance of tea against experimental ischemia-reperfusion (IR) injury of the small intestine in rats, found that quercetin administrated intraperitoneally 30min before 1h ischemia of superior mesenteric artery with following reperfusion periods lasting 1, 4 and 24h significant decreases cyclooxygenase-2 (COX-2) enzyme in the epithelial lining of the intestinal villi in expression of normal cell apoptosis only during 24h of reperfusion in a late phase of IR injury in comparison with the control group.
According to the observation of the morphology of COX-2 positive cells, COX-2 positivity was found particularly in goblet cells with a function in secreting the main component of mucus.of the intestinal villi epithelium and enteroendocrine cells found in the wall of the gut that secrete hormones that regulate glucose levels, food intake, and stomach emptying respectively, in the glandular epithelium in the group I mice in compared to significantly lesser levels in green tea group.
Dr. Tóth Š, the lead authors at the joint study said," Quercetin application attenuated mucosal damage from IR injury by inhibiting neutrophil infiltration which was demonstrated by a lower number of myeloperoxidase positive cells in the lamina propria".
In another similar study with male-specific pathogen-free (SPF) Charles River Wistar rats were used in the experiment with quercetin administered intraperitoneally 30min before 1h ischemia of superior mesenteric artery with following 24h lasting reperfusion period., researchers at the joint study lead by the Pavol Jozef Safarik University, also indicated that application of quercetin increases the production of anti-inflammatory cytokine IL10 observed by analysis of the blood sample and jejunal tissue and in the number of CD68-positive cells in the lamina propria mucosae (p<0.001) in initiation of production of new blood vessels growth and inflammatory cytokines in compared to control group.
Dr. Curgali K, the lead authors, after taking into account of other con-founders, said, "The preventive application of quercetin before induction of jejunal IRI stimulates faster jejunal mucosa restoration and it seems to have immunomodulatory and anti-inflammatory effects" and "CD68-positive macrophages could have crucial role in this process since they work as both growth factor and cytokine producers".
Taken together, green tea with abundant bioactive phytochemicals such as quercetin may be considered a functional food with reduced risk and prevented the onset of intestinal ischemia. People with a high risk of the development of intestinal ischemia may consider adding 1 or 2 cups of green tea to their daily diet.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of green tea on intestinal ischemia-reperfusion injury by Abdeen SM1, Mathew TC, Dashti HM, Asfar S.(PubMed)
(2) Quercetin attenuates the ischemia reperfusion induced COX-2 and MPO expression in the small intestine mucosa by Tóth Š1, Jonecová Z1, Čurgali K1, Maretta M2, Šoltés J1, Švaňa M1, Kalpadikis T1, Caprnda M3, Adamek M4, Rodrigo L5, Kruzliak P6.(PubMed)
(3) Quercetin protects jejunal mucosa from experimental intestinal ischemia-reperfusion injury by activation of CD68 positive cells by Curgali K1, Toth S1, Jonecova Z1, Maretta M2, Kalpakidis T1, Petriskova I1, Kusnier M1, Soltes J1, Svana M1, Caprnda M3, Delev D4, Rodrigo L5, Mechirova E1, Kruzliak P6.(PubMed)
Green tea may have a therapeutic and positive effect in reduced risk and treatment of intestinal ischemia, some scientists suggested.
Intestinal ischemia is a serious medical condition characterized by reduced blood flow to the
intestines.
In the evaluated 3 groups of male rats randomly assigned to Group I (ischemia-reperfusion, I/R) underwent I/R of the intestine (30 min of ischemia followed by 1 h of reperfusion). Group II (green tea + I/R) was given green tea for 2 wk before inducing I/R. In Group III (control) with sham I/R, researchers found that the injection of the green tea group showed an impressive restoration of intestinal mucosa compared to the ischemia-reperfusion (I/R) group.
In observation of cellular antioxidant profile (superoxide dismutase and catalase), the green tea group expressed a significant improvement of antioxidants similar to those of group III and in compared to group II.
The expressions of cellular proliferation markers (proliferating cell nuclear antigen and Ki-67) in regulated intestinal cell division and proliferation were also increased by green tea application.
The above illustration indicated that long term intake of green tea injection may exhibit strong protection against the intestinal mucosa from injury.
Further differentiation of the effect of Quercetin, the bioactive substance of tea against experimental ischemia-reperfusion (IR) injury of the small intestine in rats, found that quercetin administrated intraperitoneally 30min before 1h ischemia of superior mesenteric artery with following reperfusion periods lasting 1, 4 and 24h significant decreases cyclooxygenase-2 (COX-2) enzyme in the epithelial lining of the intestinal villi in expression of normal cell apoptosis only during 24h of reperfusion in a late phase of IR injury in comparison with the control group.
According to the observation of the morphology of COX-2 positive cells, COX-2 positivity was found particularly in goblet cells with a function in secreting the main component of mucus.of the intestinal villi epithelium and enteroendocrine cells found in the wall of the gut that secrete hormones that regulate glucose levels, food intake, and stomach emptying respectively, in the glandular epithelium in the group I mice in compared to significantly lesser levels in green tea group.
Dr. Tóth Š, the lead authors at the joint study said," Quercetin application attenuated mucosal damage from IR injury by inhibiting neutrophil infiltration which was demonstrated by a lower number of myeloperoxidase positive cells in the lamina propria".
In another similar study with male-specific pathogen-free (SPF) Charles River Wistar rats were used in the experiment with quercetin administered intraperitoneally 30min before 1h ischemia of superior mesenteric artery with following 24h lasting reperfusion period., researchers at the joint study lead by the Pavol Jozef Safarik University, also indicated that application of quercetin increases the production of anti-inflammatory cytokine IL10 observed by analysis of the blood sample and jejunal tissue and in the number of CD68-positive cells in the lamina propria mucosae (p<0.001) in initiation of production of new blood vessels growth and inflammatory cytokines in compared to control group.
Dr. Curgali K, the lead authors, after taking into account of other con-founders, said, "The preventive application of quercetin before induction of jejunal IRI stimulates faster jejunal mucosa restoration and it seems to have immunomodulatory and anti-inflammatory effects" and "CD68-positive macrophages could have crucial role in this process since they work as both growth factor and cytokine producers".
Taken together, green tea with abundant bioactive phytochemicals such as quercetin may be considered a functional food with reduced risk and prevented the onset of intestinal ischemia. People with a high risk of the development of intestinal ischemia may consider adding 1 or 2 cups of green tea to their daily diet.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effects of green tea on intestinal ischemia-reperfusion injury by Abdeen SM1, Mathew TC, Dashti HM, Asfar S.(PubMed)
(2) Quercetin attenuates the ischemia reperfusion induced COX-2 and MPO expression in the small intestine mucosa by Tóth Š1, Jonecová Z1, Čurgali K1, Maretta M2, Šoltés J1, Švaňa M1, Kalpadikis T1, Caprnda M3, Adamek M4, Rodrigo L5, Kruzliak P6.(PubMed)
(3) Quercetin protects jejunal mucosa from experimental intestinal ischemia-reperfusion injury by activation of CD68 positive cells by Curgali K1, Toth S1, Jonecova Z1, Maretta M2, Kalpakidis T1, Petriskova I1, Kusnier M1, Soltes J1, Svana M1, Caprnda M3, Delev D4, Rodrigo L5, Mechirova E1, Kruzliak P6.(PubMed)
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