#Healthyfood #Greentea #Polyphenols Exhibit The Anti-Inflammatory Activities Against the Onset of #Colitis, Scientists Say

By Kyle J. Norton

Green tea may have a therapeutic and profound effect on reduced risk and treatment of colitis, some scientists suggested.

Green tea, a precious drink processes a numbers of health benefits known to almost everyone in Asia and the Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Colitis is a medical condition characterized by inflammation of the inner lining of the colon as a result of infection, inflammation caused by other bowel diseases.

In the comparison of the effects of green tea extract epigallocatechin-3-gallate, EGCG and
Piper nigrum (L.) alkaloid piperine in mice colitis induced by oral administration of dextran sodium sulfate randomly assigned to a daily oral administration of 6.9 mg/kg body weight EGCG or Piper nigrum (L.) piperine (2.9 mg/kg body weight) or the combination of the both with piperine used in the combination to enhance the bioavailability of EGCG and untreated controls, researchers at the Münster University Hospital showed that mice group treated with the combination demonstrated a significant effect in reduced weight loss and improved overall survival in compared to non treatment group through inducing lesser histological damages to the colon and reduction of tissue concentrations of malondialdehyde, an indication of decreased oxidative stress.

According to neutrophils accumulation assay, the application of green tea EGCG and piperine displayed a strong activity in reduced ROS expression in the induction of lipid peroxidation through activation of overexpression of antioxidant enzymes such as superoxide dismutase(SOD) and glutathione peroxidase(GPO).

Further examining also found that the combined ingredients induced an also reduced the production of proinflammatory cytokines.


Dr. Brückner M, after taking into account of other con-founders suggested, "the concept of anti-inflammatory properties of EGCG being generally beneficial in the DSS-model of colitis".

Interestingly, in dextran sulfate sodium (DSS)-induced mouse model of colitis, application of green tea EGCG (3.2 mg/g) as a source of drinking fluid for 3 days exerted a significant effect in ameliorated of colon shortening and spleen enlargement caused by injection of DSS and modulated the production of levels inflammatory cytokines of of interleukin 1 beta (IL-1β) and
Interleukin 6 (IL-6), which plays an important role in the regulation of immune and inflammatory responses to acute and chronic infections.

Furthermore, green tea oral administration also decreased levels of tumor necrosis factor-α, a cell-signaling protein in activated systemic inflammation and pro-inflammatory cytokines in the acute phase of reaction and inhibited ROS expression colonic lipid peroxides through antioxidant activity.


Moreover, the bioactive polyphenol EGCG also improved the small intestinal function in reduced leaky gut, associated with the risk of increasing the number of harmful compounds entering the bloodstream.

Further analysis of green tea efficacy in the treatment of colitis, researchers discovered that green tea EGCG also induced weight loss through the binding on the surface of the small intestine in decreased protein and lipid digestion.

In additional evaluation of green tea polyphenols (GrTP, EGCG) and sulfasalazine activity in colitis induced by injection of Dextran sodium sulfate (DSS) to cause deficiency of IL-10 in BALB/c mice, researchers at the University of Kentucky, postulated that the combined administration significantly ameliorates colonic damage and histological scores in a similar manner (GrTP vs. DSS p < 0.05; EGCG, sulfasalazine vs. DSS p < 0.01) and decrease expression of the inflammatory markers TNFα (3-fold), IL-6 (14-fold) as mentioned above.


Importantly, treated mice with both green tea polyphenols (GrTP, EGCG) and sulfasalazine also expressed a huge improvement in antioxidant capacity in inhibition of ROS in an initiated chain reaction to facilitate plagues formation and inflammation, observed by the activity of bio maker lectin levels.

The information findings insisted that green tea with abundantly selective bioactive polyphenols may be considered a functional food for the prevention and treatment of colitis. However, the intake of green tea supplements should be taken with exceptional care as acute liver toxicity was reported in a number of cases.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis by Brückner M1, Westphal S, Domschke W, Kucharzik T, Lügering A.(PubMed)
(2) (-)-Epigallocatechin-3-gallate decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion and exacerbates weight loss by Bitzer ZT1, Elias RJ1, Vijay-Kumar M2, Lambert JD3,4.(PubMed)
(3) Green Tea Polyphenols and Sulfasalazine have Parallel Anti-Inflammatory Properties in ColitisModels by Oz HS1, Chen T, de Villiers WJ.(PubMed)

#Healthyfood #Cucumber's #Cucurbitacin B (CuB) Enhances the Healthy #GutMicrobiota in Vivos, According to Studies

By Kyle J. Norton

Gut Microbiota is a community of microorganisms living in our gut. Under normal conditions, the ratio of the gut microbiome composition is balanced.
However, the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle may alternate the ratio by increasing the growth of "bad" bacteria, leading to the development of chronic diseases such as inflammatory bowel disease, obesity, cancer, and autism.

In other words, imbalance of the gut microbiota may have a strong and negative impact on immunity, digestive, fat, and carbohydrate metabolism, and the central nervous system
* In immunity, a balanced of the gut microbes showed to stimulate the immune function against inflammatory immune disorders.

* In the digestive system, balanced gut microbes protect the gut against gastrointestinal diseases and non-gastrointestinal diseases caused by the overexpression of bad bacteria.

* In carbohydrate metabolism, gut microbes influence the nutrient extraction from the diet, thus reducing the risk of obesity and obesity complication.

* Neurologically, gut microbiota can control brain insulin signaling and metabolite levels that play a critical role in neurobehaviors.

Out of many prevalent factors that cause the onset of the unbalanced ratio of gut microbiota, some researchers suggested that the Western diet may have negatively influenced to induce overgrowth of bad microorganisms in the gut.

Dr. Marit K. Zinöcker, the lead scientist wrote, "Western diet promotes inflammation that arises from both structural and behavioral changes in the resident microbiome"

And, "The environment created in the gut by ultra-processed foods, a hallmark of the Western diet, is an evolutionarily unique selection ground for microbes that can promote diverse forms of inflammatory disease".


The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound that enhances the gut microbiome composition, researchers compared the effects of carrot, cucumber, and broccoli seed flour extracts with 50% acetone on gut microbiota modulating capacity.

In vitro, all three seed flour extracts enhanced the total number of gut bacteria and altered the abundance of specific bacterial phylum or genus.

In other words, cucumber showed a potential effect to improve the ratio of gut microbiota in the flavor of the "good" bacteria, similar to those of carrot and broccoli.

In J774A.1 cells, cucumber also exerted a similar activity by protecting the microbiota that exhibits anti-inflammatory activity by suppressing LPS-induced production of pro-inflammatory cytokines, such as IL-1β and COX-2 mRNA expressions.

Furthermore, in the obesity-induced progression of metabolic disorders, especially type 2 diabetes (T2DM), cucumber not only improved IR in obese mice and relieved inflammation in adipose tissue and blood but also enhanced the microbiota composition ratios.

More precisely, cucumber improved the ratio of gut microbiome composition by promoting IR and reducing inflammation.

Taken altogether, cucumber may be used for the improvement of gut microbiota, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chemical Compositions of Cold-Pressed Broccoli, Carrot, and Cucumber Seed Flours and Their in Vitro Gut Microbiota Modulatory, Anti-inflammatory, and Free Radical Scavenging Properties by Choe U1, Li Y1,2, Gao B2, Yu L1, Wang TTY, Sun J, Chen P, Liu J3, Yu L. (PubMed)
(2) Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the GutMicrobiome in Lepob/Lepob Mice by Lee D1, Yoo JH1, Lee BC. (PubMed)
(3) The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease by Marit K. Zinöcker1,* and Inge A. Lindseth. (PMC)

#Healthyfood #CranberryJuices Improve Symptoms and Quality of Life in Patients with Rheumatoid Arthritis, According to Clinical Trial

By Kyle J. Norton

Rheumatoid Arthritis is a chronic disorder characterized by inflammation of the flexible (synovial) joints and tissues and organs in the body.
The disease affects more women than men and generally occurs after the age of 40, causing the diminished quality of life of many elders.

According to the statistics provided by the CDC, musculoskeletal disorders (MSDs) affect over 52 million adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.

Rheumatoid arthritis was found to induce bone loss through elevating bone resorption without increasing bone formation.

Patients with rheumatoid arthritis (RA) often associate to valgus deformities of the feet and deformities of gait due to body function due to an effort to support the collapsing longitudinal arch of the foot.

Long-term bone damage and the prolonged onset of the disease can induce deformities of the hand and wrist and small peripheral joints (such as fingers and wrist) due to chronic inflammation.

The effects of muscle strength in patients with RA may contribute to the prevalence of functional limitations physically that can affect daily living and quality of life.

Furthermore, rheumatoid nodules, lumps on the skin, closed to the joint have been found to affect the joints of patients with RA.

Moreover, morning stiffness, a marker of inflammatory activity that reflects functional disability and pain is a very common symptom of patients in the early stage of rheumatoid arthritis.


In finding a potential compound for the treatment of inflammatory disease, researchers examined the effect of cranberry juice consumption on several inflammatory biomarkers and on the disease activity of patients with RA.

The prospective study included 41 women diagnosed with RA.randomly divided into a control group (n = 18) that maintained their usual diet and the cranberry group (n = 23) received 500 mL/d of low-calorie cranberry juice.

Compared to baseline values, the cranberry group showed a decrease in the values of Disease Activity Score 28 (DAS28) (P = 0.048) and anti-cyclic citrullinated peptide (anti-CCP), the antibody present in most rheumatoid arthritis patients (P = 0.034) after 90 d of treatment without affecting the inflammatory biomarkers.

The results strongly suggested that cranberry juice improves rheumatoid arthritis symptoms and decreases the disease activity that benefits RA patients.

Taken altogether, cranberry may be considered a remedy for the improvement of rheumatoid arthritis, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cranberry juice decreases disease activity in women with rheumatoid arthritis by Thimóteo NSB1, Iryioda TMV1, Alfieri DF1, Rego BEF1, Scavuzzi BM1, Fatel E2, Lozovoy MAB3, Simão ANC3, Dichi I. (PubMed)

#Healthyfood #Chickpeas #Isoflavones Kill #BreastCancer Cells, According to Studies

By Kyle J. Norton
Scientists may have found an ingredient from Chickpeas with a substantial and potential impact on breast cancer risk, some studies suggested.

Isoflavones are phytoestrogens derived from a plant with magnificent estrogenic properties.
Garbanzo beans also known as chickpea are an edible legume of genus Cicer and the family Fabaceae, high in protein and minerals. It is one of the earliest cultivated vegetables, native to the Middle East.

The investigation of the effects of isoflavones extracted from chickpeas in ameliorated risk and treatment of breast cancer was found to associate with a number of aspects and mechanisms.

Indeed, injection of isoflavones isolated from seeds and sprouts of chickpeas displayed a significant effect in inhibition of human breast cancer cell lines SKBr3 and Michigan Cancer Foundation-7 (MCF-7) at a dose of ICS at 10-60 µg/mL.

According to the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays, the phytochemicals significantly restrained the proliferation of both cell lines in a time-dependent and dose-dependent fashion.


Additionally, observation based on results from Wright-Giemsa staining as well as annexin V-fluorescein isothiocyanate and propidium iodide (Annexin V/PI) staining, the inhibition of the phytoestrogen administration also can be seed through increased cytolysis and physical body of cells death.
Cytoclasis is the presence of destruction of cells by fragmentation

Quantitative Annexin V/PI assays further showed that an increased dose of isoflavones application resulted in an increased number of apoptotic cells.
In fact, the effect of ICS in promoted apoptosis of both cancer cell lines may also be a result of activation of the expression of gene Bcl-2-associated X protein in induced cell death and decreased gene Bcl-2-in expression of anti-apoptotic activity, observed by the semiquantitative reverse transcription PCR.

The bcl-2 family protein is a modulator responsible for the regulation of cell apoptosis.

Further Western blot analysis also found that ICS injection also expressed a significantly restricted proliferation of cancer cell lines SKBr3 and MCF-7 through the increased expression of caspase 7, caspase 9 in regulated cell apoptosis and tumor suppressors P53, and mediator of cell cycle arrest P21 in a dose-dependent manner.

Interestingly, in flow cytometry assays using the fluorescent probe 3,3'-dihexyloxacarbocyanine iodide showed a dose-dependent in decreased mitochondrial membrane potential following ICS treatment.

Treatment using ICS also increased reactive oxygen species production that can be deadly to cancer cells through elevating toxicity without harming nearby healthy cells.

Decreased mitochondrial membrane potential may deplete cell energy which plays an important role in cancer cells' survival and proliferation.

Truly, the effect of isoflavones in target breast cancer would vary from being antiestrogenic to weakly estrogenic depending on the high or low endogenous estrogen levels in patients.

Furthermore, in comparison to the soybean-derived protease inhibitor Bowman-Birk inhibitor (BBI), is currently showing great promise as a novel cancer chemopreventive agent and 7 protease inhibitor concentrates (PIC) isolated from various leguminous sources (including soybean)to evaluate the effects of PIC on the proliferation of breast cancer cell line MDA-MB-231, application of chickpea PIC demonstrated a significantly inhibited viability of the cancer cell line at concentration doses of 25-400 μg/ml.

Protease inhibitors are a class of antiviral medicine with the function of binding to viral proteases to prevent replication.

Finally, although epidemiological studies suggest that isoflavones can decrease breast cancer risk and increase survival of breast cancer patients but the University of Houston has raised several questions about the results by stating, "the effects of isoflavones on mammary gland stem cells during different periods of life need to be defined to identify windows of time in which isoflavones can have positive or negative effects on cancer prevention. Investigations of the effect of isoflavones on breast cancer stem cells would increase our knowledge of whether isoflavones are beneficial or not to cancer patients. Lastly, the possibility that isoflavones have different effects on breast cancer risks between different ethnic groups with different genetic backgrounds needs to be taken into account".

Taken together, chickpeas phytochemicals may have a potential effect in reducing the risk and treatment of breast cancer, but a complex and large sample size with different ethnic groups with different genetic backgrounds study is necessary to reaffirm this viability.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources

(1) Isoflavones extracted from chickpea Cicer arietinum L. sprouts induce mitochondria-dependent apoptosis in human breast cancer cells by Chen H1, Ma HR, Gao YH, Zhang X, Habasi M, Hu R, Aisa HA.(PubMed)
(2) Chickpea (Cicer arietinum) and other plant-derived protease inhibitor concentrates inhibit breast and prostate cancer cell proliferation in vitro by Magee PJ1, Owusu-Apenten R, McCann MJ, Gill CI, Rowland IR.(PubMed)
(3) Does consuming isoflavones reduce or increase breast cancer risk? byBondesson M1, Gustafsson JA.(PubMed)

#Healthyfood #CookedTomato's #Lycopene Protects Protein, Lipid and Cell Damage Caused by Overexpression of #OxidativeStress, According to Studies

By Kyle J. Norton

Oxidative stress is a condition characterized by overexpression of free radicals in the body.

In other words, oxidative stress is a result of the imbalance of the ratio of free radicals and antioxidants caused by abundant free radicals and low levels of antioxidant enzymes produced by the body.

A free radical is an unstable atom with a single electron on the outermost ring. Given its nature, free radical readily donates or intercepts an electron from another atom, leading to a chain of the free radical cascade that cannot be stopped until all single electron is paired or inhibited by antioxidants.

The antioxidant is a stable atom with a function to inhibit oxidation and comes either from dietary sources or produced by the body.

In contrast to general belief, a free radical is also needed in moderated amounts for the function of the heart muscle to pump blood such as NO for vasodilation and increasing blood flow.

According to studies, in cancer, oxidative stress has been found to induce cytotoxicity used in chemotherapy for the treatment of cancer by killing cancer cells.

However, in a healthy person, oxidative stress is harmful because it not only induces cells' lipid and protein oxidation but also causes the change of cell DNA, leading to diseases associated with oxidative stress including cancer, diabetes, and cardiovascular disease.

Ozone, certain pesticides, and cleaners, cigarette smoke, radiation, and pollution are some of the risk factors associated with the increased risk of oxidative stress.

Based on the oxidative stress theory of aging oxidative stress, oxidative stress is also the main culprit contributing to aging in humans.

Dr. Ilaria Liguori, the lead scientist said, "Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages".

Tomato is red, edible fruit, genus Solanum, and belongs to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to find a potential compound for the treatment of diseases associated with oxidative stress researchers examined the efficacy of lycopene a carotenoid commonly found in tomatoes and tomato products.


A total of 23 healthy postmenopausal women, 50-60 years old, were provided blood samples at baseline and following a one-month lycopene-depletion period according to the St. Michael's Hospital, Toronto, ON, Canada. PARTICIPANTS AND STUDY DESIGN.
Compared to the blood sample before and after experiment samples, a one-month lycopene-depletion period diet showed a significantly decreased antioxidant profile including serum lycopene, lutein/zeaxanthin, and glutathione peroxidase (GPx).

Furthermore, the diet also depressed levels of antioxidant enzymes superoxide dismutase (SOD), and catalase (CAT), significantly in the participants while increasing levels of lipid and protein oxidation.
In other words, tomatoes restrictive diet increased the risk of diseases associated with oxidative stress in postmenopausal women due to the increase of ROS and depletion of antioxidants in the tissues.


In order to reveal more information about the tomato effect against oxidative stress, researchers conducted a study to determine whether lycopene would act as an antioxidant to decrease oxidative stress parameters.
The study included a total of 60 postmenopausal women, 50-60 years old, following a 1-month washout without lycopene consumption,.


After a month, the participants were randomly divided into groups with 15 members each consuming either : (1) regular tomato juice, (2) lycopene-rich tomato juice, (3) tomato Lyc-O-Mato lycopene capsules, or (4) placebo capsules, twice daily for total lycopene intakes of 30, 70, 30, and 0 mg/day respectively for 4 months.


According to the tested assays, for 4 months significantly increased serum lycopene compared to placebo.

Moreover, the total serum antioxidant capacity (TAC) and decreasing lipid and protein peroxidation were found to increase substantially in the groups treated with consumed juice or lycopene capsules compared to the placebo group.

Taken altogether, tomatoes and their major bioactive compound lycopene may be considered remedies for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausalwomen by Mackinnon ES1, Rao AV, Rao LG. (PubMed)
(2) Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women by Mackinnon ES1, Rao AV, Josse RG, Rao LG. (PubMed)
(3) Oxidative stress, aging, and diseases by Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6Domenico Bonaduce,1 and Pasquale Abete. (PMC)

#BlackBean's Flavonoids Exhibit Antioxidant and Antiproliferative Activities Against #BreastCancer Cells in Vitro, According to Studies

By Kyle J. Norton

Intake of a portion of black bean regularly may reduce the risk of early-onset and treatment of breast cancer, a renowned institute study suggested.
Breast cancer (malignant breast neoplasm) is a condition of abnormal cell growth in the breast area.

Breast cancer in most cases starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. but in rare instances, breast cancer may arise from other areas of the breast.


Black beans, small roughly ovoid legumes with glossy black shells, genus Phaseolus, and belongings to the family Fabaceae can buy in most grocery stores all around the year in dried and canned forms. It is believed that black bean was the first domesticated growth in South America.

In the study of water-soluble condensed tannins isolated from black beans against Hs578T breast cancer cells, the preparation at 0.24-24 microM in dose-dependent induced cancer cell death by apoptosis but did not affect the growth of normal cells, as shown by observation assay.
The efficacy of water-soluble black bean condensed tannins at 24 microM in suppressing the breast cancer cells may be attributed to the phytochemicals in reduced coagulation of remaining blood in stimulated cancer cell migration and regulated the growth of breast tumor in the formation of new blood vessels.


Furthermore, according to the National Taiwan University, fermentation products of soybean, black bean, and green bean mixture (BN999) showed a significant effect in inhibiting the growth of human breast cancer AU565 cells in increased expression of multiple apoptotic regulators in induced apoptosis.
The fermentation product also exerted an impressive activity in induced apoptosis in various human cancer cells but not in normal human cells, Dr, Chia JS, the lead author insisted.

More importantly, Dr. Dong M, the lead researcher at Cornell University, in the finding of major phytochemicals of black bean which may have a powerful effect in the treatment of breast cancer suggested, that out of newly found flavonoids, only 6 (5, 7, 8, 9, 11, 19, 20) of them showed potent antioxidant and antiproliferative activities. against MCF-7 human breast cancer cells.

Taking together, there is no doubt that black beans may process significant anti-breast cancer properties and can be considered as a functional food for reduced risk and treatment of breast cancer.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.

Sources
(1) Inhibition of Caco-2 colon, MCF-7, and Hs578T breast, and DU 145 prostatic cancer cell proliferation by water-soluble black bean condensed tannins by Bawadi HA1, Bansode RR, Trappey A 2nd, Truax RE, Losso JN.(PubMed)
(2) Fermentation product of soybean, black bean, and green bean mixture induces apoptosis in a wide variety of cancer cells by Chia JS1, Du JL, Wu MS, Hsu WB, Chiang CP, Sun A, Lu JJ, Wang WB.(PubMed)
(3) Phytochemicals of black bean seed coats: isolation, structure elucidation, and their antiproliferative and antioxidative activities by Dong M1, He X, Liu RH. (PubMed)

#Healthyfood #Beetroot, Reduces the Risk of #CardiovascularDisease by improving the Vascular and Endothelial Functions, Studies Show

By Kyle J. Norton

Beetroot rich in inorganic nitrate may be used as dietary supplementation or functional food to improve endothelial function via reduced expression of harmful free radicals, a respectable institute study illustrated.

The endothelium is a thin membrane that lined the inside of the heart and blood vessels with function in controlling vascular relaxation and contraction, as well as enzymes that control blood clotting, immune function, and platelet adhesion.

Endothelial dysfunction, due to the inability of the arteries to dilate fully, may exhibit high blood pressure, diabetes, and high cholesterol.... promoting stroke and heart attacks.

Beet, best known as the beetroot or garden beet, belonging to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.


A total of 20 healthy overweight and slightly obese men with a BMI between 28 and 35 kg/m(2) received in random order a mixed meal of 56.6 g of fat with beetroot juice or a control drink, oral administration of beetroot juice (140 mL) with approximately 500 mg dietary nitrate group, showed a significant improvement of postprandial endothelial function in compared control.

The efficacy of beet juice in attenuated postprandial impairment of flow-mediated dilation (FMD) following a mixed meal, is probably due to the expression of increased plasma NO concentrations in the bloodstream, according to the Maastricht University Medical Center.

Furthermore, beetroots with biological activity provided a natural source of nitric oxide (NO) in reduced risk of endothelium dysfunction inducing the imbalance between vasodilation and vasoconstriction of arterial vessels.

The study also suggested that phytochemical betalain isolated from beetroot may also hold a significant effect in maintaining healthy endothelium function, acting simultaneously with increasing levels of nitric oxide (NO).

More importantly, the review database of literature from MEDLINE, EMBASE, and Scopus databases from inception until November 2014, 9 crossover trials and three parallel trials met inclusion criteria, including a total of 246 participants with 10-64 participants per study, also indicated the efficacy of inorganic nitrate and beetroot consumption in reduced risk of cardiovascular disease by improved vascular function. But the effect on endothelial function was significantly associated with the dose depended of inorganic nitrate, found abundantly in the vegetable

The evidence indicated that beetroot may be considered a promising therapeutic treatment in ameliorating the risk of cardiovascular disease through the improvement of vascular and endothelial functions.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
(1) Beetroot juice improves in overweight and slightly obese men postprandial endothelial function after consumption of a mixed meal by Joris PJ1, Mensink RP. (PubMed)
(2) The potential benefits of red beetroot supplementation in health and disease by Clifford T1, H Watson G2,3, West DJ4, Stevenson EJ5.(PubMed)
(3) Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysis by Lara J1, Ashor AW2,3, Oggioni C2, Ahluwalia A4, Mathers JC2, Siervo M2. (PubMed)