By Kyle J. Norton
Inflammation is a natural defense of the immune system that protects the body against the insult from foreign invasion.
Acute inflammation occurs quickly that lasts a few days or weeks. Most cases of acute inflammation-induced tissue damage are healed themselves after all pathogens are killed off.
However, if the immune system can not completely eradicate all invaders in the acute phase of infection, it will compromise, leading to chronic low-grade inflammation, a major cause of cardiovascular disease, arthritis, and diabetes.
Chronic inflammation is a low-grade inflammation caused by the inability of the immune system to eliminate the invasive pathogens that occurred in the acute phase of infection.
Any inflammation that lasts more than 8 weeks is considered chronic inflammation.
Believe it or not, worldwide, 3 of 5 death are results from chronic inflammatory diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity, and diabetes.
In the US, chronic inflammatory diseases affect more than 50 million Americans each year.
Anti-inflammation is a process that inhibits the pro-inflammatory cytokines without affecting the immune system's activity against pathogens.
Diseases associated with low-grade inflammation include diabetes and cardiovascular.
Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.
On finding a potential compound for the treatment of diseases associated with inflammation, researchers examined the anti-inflammatory effect of Tussilagone (FTF), isolated from the flower of buds of Tussilago farfara (Compositae).
The study included compounds 1-4 chlorogenic acid (1), 3,5-dicaffeoylquinic acid (2), 3,4-dicaffeoylquinic acid (3), and 4,5-dicaffeoylquinic acid (4) isolated from ETE and their mixture was determined by spectral analysis given to mice orally in a ratio of 5:28:41:26 as in EtE) at doses of 10 and 20 mg/kg once daily for 3 days. All mixtures showed a significant antitussive effect by exhibiting anti-inflammatory effects against cough frequency by 61.7%.
Compared to other compounds, compound 2 was the most potent to enhance the phenol red secretion by 35.7% in alleviating inflammation.
Compound 4 showed the strongest effect to inhibit leukocytosis by 49.7%.
Based on the findings, researchers said, "The caffeoylquinic acids and their mixture, exhibiting significant antitussive, expectorant, and anti-inflammatory effects, could be considered as the main effective ingredients of FTF, and they may act in a collective and synergistic way".
Taken altogether, coltsfoot may be considered a remedy for the treatment of disease associated with inflammatory disease, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antitussive, expectorant, and anti-inflammatory activities of four caffeoylquinic acids isolated from Tussilago farfara by Wu QZ1, Zhao DX1, Xiang J1, Zhang M1, Zhang CF1, Xu XH. (PubMed)
Thursday, 8 June 2023
Low Levels of #Lycopene Are Associated with 3-Fold Risk of #Strokes, Researchers Suggest
By Kyle J. Norton
Stroke is a medical condition caused by reduced blood flow to the brain, leading to the death of brain cells due to lack of oxygen or bleeding.
In other words, a stroke can be classified into a type of blocking artery (ischemic stroke) or the leaking or bursting of a blood vessel (hemorrhagic stroke).
A mini-stroke is a temporary disruption of blood flow to the brain that resolves in a short time without causing permanent damage to the brain.
The most common symptoms of a mini-stroke may include dysphasia, dysarthria, or physical difficulty when speaking, vision changes, confusion, balance issues, and tingling.
A blood clot is the most common cause of mini-stroke involved in high blood pressure, atherosclerosis, or narrowed arteries caused by plaque buildup, diabetes, and high blood cholesterol
However, the most common symptoms of stroke include paralysis or numbness of the face, arm or leg, problems in vision, speaking, walking, and persistent headache.
The most common prevalent factors found in post-stroke patients are diabetes. heart diseases, long-term use of tobacco, the increase in age, and ethnicity.
In examining the post-stroke patients, a poor diet pattern with a high in saturated and trans fat, red meat, and processed foods has been found in the high percentage, compared to the traditional diet.
Dr. Mehdi Foroughi, the lead scientist in the study of poor diet in the risk of stroke wrote, " Stroke is one of the leading causes of death and certainly the major cause of disability in the world. Diet and nutrients have an effective role in the prevention and control of the risk of stroke".
And, "Adherence to the Mediterranean diet or DASH diet and increasing the consumption of antioxidants, vitamins, potassium, calcium food sources, vegetables, fruits, and whole grains intake can lower the risk of stroke. A healthy diet is effective in reducing the risk of stroke".
Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas.
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
In finding a natural compound for the prevention of stroke, researchers examined the association of lycopene with the risk of stroke.
According to the results of 725 men aged 46-64 years examined in 1991-3 in the Kuopio Ischaemic Heart Disease Risk Factor Study with 41 subjects had either a fatal or a non-fatal acute coronary event or a stroke by December 1997, researchers found that men in the lowest quarter of serum lycopene levels had a 3.3-fold risk of stroke.
In other words, low levels of lycopene over a long period of time were associated with an increased risk of atherosclerotic vascular events in middle-aged men previously free of CHD and stroke.
Furthermore, the study that screens the PubMed database through October 2013 including 116,127 participants, also suggested that lycopene decreased stroke risk by 19.3%m after adjusting for confounding factors.
However, the circulating lycopene was associated with a statistically significant decrease in stroke risk compared to those of dietary lycopene.
Additionally, men are more benefits in reducing the risk of stroke with the circulating lycopene compared to women.
Taken altogether, lycopene found in tomatoes may be considered supplements for the prevention of stroke, particularly in men, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study by Rissanen TH1, Voutilainen S, Nyyssönen K, Lakka TA, Sivenius J, Salonen R, Kaplan GA, Salonen JT. (PubMed)
(2) Dietary and circulating lycopene and stroke risk: a meta-analysis of prospective studies by Li X1, Xu J. (PubMed).
Stroke is a medical condition caused by reduced blood flow to the brain, leading to the death of brain cells due to lack of oxygen or bleeding.
In other words, a stroke can be classified into a type of blocking artery (ischemic stroke) or the leaking or bursting of a blood vessel (hemorrhagic stroke).
A mini-stroke is a temporary disruption of blood flow to the brain that resolves in a short time without causing permanent damage to the brain.
The most common symptoms of a mini-stroke may include dysphasia, dysarthria, or physical difficulty when speaking, vision changes, confusion, balance issues, and tingling.
A blood clot is the most common cause of mini-stroke involved in high blood pressure, atherosclerosis, or narrowed arteries caused by plaque buildup, diabetes, and high blood cholesterol
However, the most common symptoms of stroke include paralysis or numbness of the face, arm or leg, problems in vision, speaking, walking, and persistent headache.
The most common prevalent factors found in post-stroke patients are diabetes. heart diseases, long-term use of tobacco, the increase in age, and ethnicity.
In examining the post-stroke patients, a poor diet pattern with a high in saturated and trans fat, red meat, and processed foods has been found in the high percentage, compared to the traditional diet.
Dr. Mehdi Foroughi, the lead scientist in the study of poor diet in the risk of stroke wrote, " Stroke is one of the leading causes of death and certainly the major cause of disability in the world. Diet and nutrients have an effective role in the prevention and control of the risk of stroke".
And, "Adherence to the Mediterranean diet or DASH diet and increasing the consumption of antioxidants, vitamins, potassium, calcium food sources, vegetables, fruits, and whole grains intake can lower the risk of stroke. A healthy diet is effective in reducing the risk of stroke".
Lycopene is a phytochemical found in tomatoes in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas.
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
In finding a natural compound for the prevention of stroke, researchers examined the association of lycopene with the risk of stroke.
According to the results of 725 men aged 46-64 years examined in 1991-3 in the Kuopio Ischaemic Heart Disease Risk Factor Study with 41 subjects had either a fatal or a non-fatal acute coronary event or a stroke by December 1997, researchers found that men in the lowest quarter of serum lycopene levels had a 3.3-fold risk of stroke.
In other words, low levels of lycopene over a long period of time were associated with an increased risk of atherosclerotic vascular events in middle-aged men previously free of CHD and stroke.
Furthermore, the study that screens the PubMed database through October 2013 including 116,127 participants, also suggested that lycopene decreased stroke risk by 19.3%m after adjusting for confounding factors.
However, the circulating lycopene was associated with a statistically significant decrease in stroke risk compared to those of dietary lycopene.
Additionally, men are more benefits in reducing the risk of stroke with the circulating lycopene compared to women.
Taken altogether, lycopene found in tomatoes may be considered supplements for the prevention of stroke, particularly in men, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study by Rissanen TH1, Voutilainen S, Nyyssönen K, Lakka TA, Sivenius J, Salonen R, Kaplan GA, Salonen JT. (PubMed)
(2) Dietary and circulating lycopene and stroke risk: a meta-analysis of prospective studies by Li X1, Xu J. (PubMed).
#Antioxidant #Betaxanthins Process Anti-Proliferative Activities Against #Cancers, Researchers Suggest
By Kyle J. Norton
Cancer is a group of chronic and medical diseases associated with the growth of irregular cells caused by DNA alternation.
Most cases of that start in the cells of the inner lining of a tissue or organ before penetrating into deeper layers to form a tumor.
At the advanced stage, the invasive cells may travel a distance away from the primary site to infect other healthy tissue of the organs, through lymph and blood, leading to secondary metastasis.
Some cancers can be slow-growth including prostate and colon cancer. Primary cancer at stage 0 and 1 may not induce any symptoms. However, at the later stage, a larger size tumor can induce specific symptoms depending on the affected organ accompanied by some general symptoms found in all types of cancer.
According to the statistics, in Canada, lung, colorectal, breast, and prostate cancers accounted for about half of all cancer diagnoses and deaths. Approximately, 1 in 2 Canadians will develop cancer in their lifetimes and 1 in 4 will die of the disease.
Most cancers diagnosed in the very early stage have a 5 years survival rate close to 100%. Therefore, People who are at a higher risk of cancer onset should have an annual examination to catch cancer in the early stage.
The causes of cancer are unknown. age, family, genetic preposition, alcohol, cancer-causing Substances, chronic inflammation, hormones, immunosuppression, are some of the common prevalent factors found in cancer patients./
Some researchers suggested, the widespread obesity in the Western world due to the promotion of a high-fat diet over the past few decades are correlated to the incidences of cancer onset,
The IFL science in the article "Scientists Discover How High-Fat Diets Can Cause Cancer" wrote, "in the mice on a high-fat diet, activation of PPAR-delta in intestinal progenitor cells – daughters of stem cells that are along the road of specialization – caused them to behave like stem cells, increasing their lifespan and endowing them the ability to form mini-intestines in a dish. Importantly, when the team deleted a gene in these cells that are often mutated in colon cancer, the cells obtained the capacity to form tumors".
Conventionally, the treatment of cancers completely depends on the types and grades of cancer. Some people with cancer at an early stage may only need one treatment. But most people with cancer in the later stage have a combination of treatments, including surgery with chemotherapy and/or radiation therapy.
Betaxanthins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.
With an aim to find a potent ingredient for the treatment of invasive tumors, researchers examined the anti-cancer effects of C-glycosyl flavonoids from Beta vulgaris Cicla and betalains from Beta vulgaris rubra.
In other words, the study was to compare the anti-cancer activity of chemical compounds among green beet (Beta vulgaris var. cicla L, apigenin, vitexin, vitexin-2-O-xyloside, and vitexin-2-O-rhamnoside, .) and red beetroot (B. vulgaris var. Rubra L., betaxanthins, and betacyanins).
All tested compounds showed significant antioxidant activity, anti-inflammatory, and antiproliferative activities during the course of the experiment.
A combination of Vitexin-2-O-xyloside, betaxanthins, and betacyanins exerted antiproliferative activity against breast, liver, colon, and bladder cancer cell lines, in vitro.
Furthermore, all phytochemicals demonstrated anti-cancer efficacy by inhibiting the proteins associated with pro-survivals and genes involved in the inhibition of apoptosis.
Moreover, the genes that promote controlling angiogenesis, and hypoxia-inducible factor 1A associated with metastasis were also inhibited by the injection of all these compounds.
Additionally, Vitexin-2-O-xyloside, betaxanthins, and betacyanins are used in combination with conventional anticancer drugs not only to reduce drug toxicity but also to overcome the multidrug resistance of cancer cells.
Based on the findings, researchers said, "enable these dietary phytochemicals to block the proliferation of tumor cells and inhibit their pro-survival pathways.".
Taken altogether, betaxanthins used alone or combined with other phytochemicals may be considered remedies for cancer prevention and treatment, pending confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer, and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES. (PubMed)
(2) Scientists Discover How High-Fat Diets Can Cause Cancer by IFL science
Cancer is a group of chronic and medical diseases associated with the growth of irregular cells caused by DNA alternation.
Most cases of that start in the cells of the inner lining of a tissue or organ before penetrating into deeper layers to form a tumor.
At the advanced stage, the invasive cells may travel a distance away from the primary site to infect other healthy tissue of the organs, through lymph and blood, leading to secondary metastasis.
Some cancers can be slow-growth including prostate and colon cancer. Primary cancer at stage 0 and 1 may not induce any symptoms. However, at the later stage, a larger size tumor can induce specific symptoms depending on the affected organ accompanied by some general symptoms found in all types of cancer.
According to the statistics, in Canada, lung, colorectal, breast, and prostate cancers accounted for about half of all cancer diagnoses and deaths. Approximately, 1 in 2 Canadians will develop cancer in their lifetimes and 1 in 4 will die of the disease.
Most cancers diagnosed in the very early stage have a 5 years survival rate close to 100%. Therefore, People who are at a higher risk of cancer onset should have an annual examination to catch cancer in the early stage.
The causes of cancer are unknown. age, family, genetic preposition, alcohol, cancer-causing Substances, chronic inflammation, hormones, immunosuppression, are some of the common prevalent factors found in cancer patients./
Some researchers suggested, the widespread obesity in the Western world due to the promotion of a high-fat diet over the past few decades are correlated to the incidences of cancer onset,
The IFL science in the article "Scientists Discover How High-Fat Diets Can Cause Cancer" wrote, "in the mice on a high-fat diet, activation of PPAR-delta in intestinal progenitor cells – daughters of stem cells that are along the road of specialization – caused them to behave like stem cells, increasing their lifespan and endowing them the ability to form mini-intestines in a dish. Importantly, when the team deleted a gene in these cells that are often mutated in colon cancer, the cells obtained the capacity to form tumors".
Conventionally, the treatment of cancers completely depends on the types and grades of cancer. Some people with cancer at an early stage may only need one treatment. But most people with cancer in the later stage have a combination of treatments, including surgery with chemotherapy and/or radiation therapy.
Betaxanthins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.
With an aim to find a potent ingredient for the treatment of invasive tumors, researchers examined the anti-cancer effects of C-glycosyl flavonoids from Beta vulgaris Cicla and betalains from Beta vulgaris rubra.
In other words, the study was to compare the anti-cancer activity of chemical compounds among green beet (Beta vulgaris var. cicla L, apigenin, vitexin, vitexin-2-O-xyloside, and vitexin-2-O-rhamnoside, .) and red beetroot (B. vulgaris var. Rubra L., betaxanthins, and betacyanins).
All tested compounds showed significant antioxidant activity, anti-inflammatory, and antiproliferative activities during the course of the experiment.
A combination of Vitexin-2-O-xyloside, betaxanthins, and betacyanins exerted antiproliferative activity against breast, liver, colon, and bladder cancer cell lines, in vitro.
Furthermore, all phytochemicals demonstrated anti-cancer efficacy by inhibiting the proteins associated with pro-survivals and genes involved in the inhibition of apoptosis.
Moreover, the genes that promote controlling angiogenesis, and hypoxia-inducible factor 1A associated with metastasis were also inhibited by the injection of all these compounds.
Additionally, Vitexin-2-O-xyloside, betaxanthins, and betacyanins are used in combination with conventional anticancer drugs not only to reduce drug toxicity but also to overcome the multidrug resistance of cancer cells.
Based on the findings, researchers said, "enable these dietary phytochemicals to block the proliferation of tumor cells and inhibit their pro-survival pathways.".
Taken altogether, betaxanthins used alone or combined with other phytochemicals may be considered remedies for cancer prevention and treatment, pending confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) C-Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer, and Antiinflammatory Activities-A Review by Ninfali P1, Antonini E1, Frati A1, Scarpa ES. (PubMed)
(2) Scientists Discover How High-Fat Diets Can Cause Cancer by IFL science
#Bromelain Inhibits the Risk of #Oxidativestress, According to Studies
By Kyle J. Norton
Antioxidants are stable molecules that play an essential role in inhibiting oxidation caused by free radicals.
Free radicals are unstable and highly reactive molecules with a single electron in the outermost ring. Therefore, in order to maintain stability, free radicals either donate or intercept an electron from other stable molecules, leading to a chain of reaction that can not be stopped until all single electron in the outermost ring is paired or inhibited by antioxidants.
Overexpression of free radicals and reduced production of antioxidant enzymes by the body induce oxidative stress. Over time, oxidative stress can cause protein, lipid, and cell damage, leading to chronic diseases, including cardiovascular disease and diabetes.
There are 2 types of antioxidants. antioxidants enzymes produced by the liver and the dietary sources, including
* Antioxidant enzymes from dietary protein and minerals, including superoxide dismutase (SOD), glutathione peroxidase, glutathione reductase, and catalases.
* Antioxidant vitamins found in supplements or daily intake of food. such as vitamins A, C, E, folic acid, and beta-carotene. Most antioxidant vitamin process a free radical scavenging activity.
In other words, they gobble up free radicals before they can cause a chain of reaction.
* Antioxidant phytochemicals are found mainly in the plant's second metabolites including fruits and vegetables, carotenoids, flavonoids, allyl sulfides, and polyphenols.
Believe it or not, in a healthy individual, antioxidants produced by the liver are more than enough to balance the production of free radicals. However, in people with a weakened immune system, the intake of antioxidants from dietary sources and supplements may be necessary.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential ingredient for the treatment of disease associated with oxidative stress, researchers evaluated the ameliorative efficacy of bacoside A and bromelain on oxidative stress biomarkers in the serum of dichlorvos-intoxicated mice.
The experiment included mice that were allocated into six groups. The first group received saline as a vehicle; a second group was administered dichlorvos (40 mg/kg b.w.); the third group was administered bromelain (70 mg/kg b.w.), the fourth group received a dose of bacoside A (5 mg/kg b.w.), the fifth group was given concomitant exposure of bacoside A and bromelain both and mice of the sixth group were exposed to bacoside A, bromelain and dichlorvos for 21 days consecutively
The group treated with dichlorvos showed a significant increase in oxidative stress biomarkers thiobarbituric acid reactive substances (TBARS) and protein carbonyl content (PCC)
The results suggested that dichlorvos stimulates the production of free radicals in mice.
Bromelain and dichlorvos treated group showed a strong effect in the inhibition of the free radical expression induced by dichlorvos.
Furthermore, co-administration of bromelain and bacoside A in dichlorvos-exposed mice also displayed a significant effect in reversing the level of CAT, SOD, GPx, and GSH (p < 0.05) which was decreased due to the dichlorvos administration.
Based on the findings, researchers said, "Findings of research conclude that concomitant exposure of bacoside A and bromelain was much effective in combating oxidative stress induced by dichlorvos".
Taken altogether, bromelain may be considered a supplement for preventing and treating diseases associated with oxidative stress, pending confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bacoside A and bromelain relieve dichlorvos induced changes in oxidative responses in mice serum by Agarwal S1, Chaudhary B2, Bist R. (PubMed)
Antioxidants are stable molecules that play an essential role in inhibiting oxidation caused by free radicals.
Free radicals are unstable and highly reactive molecules with a single electron in the outermost ring. Therefore, in order to maintain stability, free radicals either donate or intercept an electron from other stable molecules, leading to a chain of reaction that can not be stopped until all single electron in the outermost ring is paired or inhibited by antioxidants.
Overexpression of free radicals and reduced production of antioxidant enzymes by the body induce oxidative stress. Over time, oxidative stress can cause protein, lipid, and cell damage, leading to chronic diseases, including cardiovascular disease and diabetes.
There are 2 types of antioxidants. antioxidants enzymes produced by the liver and the dietary sources, including
* Antioxidant enzymes from dietary protein and minerals, including superoxide dismutase (SOD), glutathione peroxidase, glutathione reductase, and catalases.
* Antioxidant vitamins found in supplements or daily intake of food. such as vitamins A, C, E, folic acid, and beta-carotene. Most antioxidant vitamin process a free radical scavenging activity.
In other words, they gobble up free radicals before they can cause a chain of reaction.
* Antioxidant phytochemicals are found mainly in the plant's second metabolites including fruits and vegetables, carotenoids, flavonoids, allyl sulfides, and polyphenols.
Believe it or not, in a healthy individual, antioxidants produced by the liver are more than enough to balance the production of free radicals. However, in people with a weakened immune system, the intake of antioxidants from dietary sources and supplements may be necessary.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential ingredient for the treatment of disease associated with oxidative stress, researchers evaluated the ameliorative efficacy of bacoside A and bromelain on oxidative stress biomarkers in the serum of dichlorvos-intoxicated mice.
The experiment included mice that were allocated into six groups. The first group received saline as a vehicle; a second group was administered dichlorvos (40 mg/kg b.w.); the third group was administered bromelain (70 mg/kg b.w.), the fourth group received a dose of bacoside A (5 mg/kg b.w.), the fifth group was given concomitant exposure of bacoside A and bromelain both and mice of the sixth group were exposed to bacoside A, bromelain and dichlorvos for 21 days consecutively
The group treated with dichlorvos showed a significant increase in oxidative stress biomarkers thiobarbituric acid reactive substances (TBARS) and protein carbonyl content (PCC)
The results suggested that dichlorvos stimulates the production of free radicals in mice.
Bromelain and dichlorvos treated group showed a strong effect in the inhibition of the free radical expression induced by dichlorvos.
Furthermore, co-administration of bromelain and bacoside A in dichlorvos-exposed mice also displayed a significant effect in reversing the level of CAT, SOD, GPx, and GSH (p < 0.05) which was decreased due to the dichlorvos administration.
Based on the findings, researchers said, "Findings of research conclude that concomitant exposure of bacoside A and bromelain was much effective in combating oxidative stress induced by dichlorvos".
Taken altogether, bromelain may be considered a supplement for preventing and treating diseases associated with oxidative stress, pending confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bacoside A and bromelain relieve dichlorvos induced changes in oxidative responses in mice serum by Agarwal S1, Chaudhary B2, Bist R. (PubMed)
#Herbal #Arnica Speeds Up Bruise Healing and Decreases Bruising and Muscle Pain , Scientists Reveal
By Kyle J. Norton
Herbal Arnica may process the property of speeding bruise healing without inducing adverse effects, some studies suggested.
A bruise is a condition characterized by black and blue marks on the skin due to trauma, caused by an object or force that strikes the body, leading to damage to capillaries and sometimes venules that allow blood to seep, hemorrhage, or extravasate into the surrounding interstitial tissues.
A bruise can also be induced by surgery caused by instruments that pierce into the deep layer of the skin to create an opening.
Most Bruising resolves itself in a few days or weeks.
Some bruises may cause pain but the pain usually goes away when the color of the area fades away.
Bruising, also known as a contusion, is defined as a condition of
Some researchers suggested that
The most common causes of bruising are sport related.
Sports physical activities can sometimes cause broken bones, strains and sprains, dislocations, torn tendons,..... and muscle swelling. Overuse of body muscles in sports is one of the risk factors that can cause, inducing bruising.
Ice and heat therapies by Appling ice or heat immediately after the injury to reduce blood flow around the area. were found to be effective in preventing bruising.
Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia.
The herb has been used in traditional medicine for centuries to treat strains, sprains, and bruises.
In the assessment of the comparative utility of topical formulations in hastening the resolution of skin bruising, researchers at Northwestern University conducted a double (patient and rater) blinded randomized controlled trial with numbers of healthy volunteers, age range 21-65 years.
After four standard bruises of 7 mm diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using a 595-nm pulsed-dye laser (Vbeam; Candela Corp., Wayland, MA, U.S.A.). On each subject, each bruising area was injected with one topical agent, including 5% vitamin K, 1% vitamin K, and 0·3% retinol, 20% arnica, or white petrolatum, twice a day for 2 weeks.
At the end of the 2 weeks experiment, researchers found that
* All four treatment scores a significant improvement in the change in the rater bruising score.
* The mean improvement associated with 20% arnica was greater than with white petrolatum (P=0·003), and the mixture of 1% vitamin K and 0·3% retinol.
* However, 5% vitamin K cream processes the highest bruise healing score compared to other applications.
These results suggested that topical 20% Arnica ointment may be able to reduce bruising more effectively than placebo and more effectively than low-concentration vitamin K formulations, such as 1% vitamin K with 0·3% retinol.
In a double-blind, placebo-controlled, randomized trial with three parallel arms to reaffirm Arnica efficacy in the control of bruising, reducing swelling, and promoting recovery after local trauma, 64 adults undergoing elective surgery for carpal tunnel syndrome were randomized to take three tablets daily of homeopathic Arnica 30C or 6C or placebo for seven days before surgery and fourteen days after surgery.
According to the summary of the experiment's final report, researchers showed
* There were no group differences in the primary outcome measures of pain (P=0.79) and bruising (P=0.45) on day four.
* Swelling and use of analgesic medication also did not differ between arnica and placebo groups.
* Adverse events were reported by 2 patients in the Arnica 6C group, 3 in the placebo group, and 4 in the Arnica 30C group.
These results strongly indicated that Arnica does not process analgesic properties.
Moreover, in the study to assess Arnica's decreases bruising and muscle pain efficacy, the Memorial Family Medicine Residency Program conducted a randomized, double-blind, placebo-controlled trial including 53 subjects.
Measurement of ankle range of motion and muscle tenderness were also recorded during Leg pain induced by calf raises.
Then, each participant received 2 tubes of cream, 1 with active Arnica and 1 with placebo.
The creams were applied to the lower legs immediately after the exercise, and again at 24 and 48 hours post-exercise according to the "RIGHT" or "LEFT" labels.
At 48 hours post-exercise, subjects had their ankle range of motion and muscle tenderness measured.
Subjects used the analog scale to rate pain in each leg at baseline, 24 hours, 48 hours, and 72 hours.
On the final day of the study, by analyzing the reports returned by participants, scientists found that
* No significant differences in pain scores were seen before exercise.
* Pain scores on legs treated with Arnica were higher than scores on those receiving placebo 24 hours after exercise respectively.
* Pain scores on day 3 and day 4 were not significantly different.
* There was no difference in muscle tenderness.
* Ankle range of motion did not differ significantly on either day 1 or day 3.
Dr. Adkison JD, the lead author suggested, Arnica may increase pain in the affected area within 48 hours immediately after application.
Taking all together, herbal Arnica may be used as a therapeutic treatment for speeding up bruise healing however, patients should be aware that topical application of herbal Arnica does not process analgesic properties. In some cases, it may increase pain in the affected area.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
2. Accelerated resolution of laser-induced bruising with topical 20% arnica: a rater-blinded randomized controlled trial. by Leu S, Havey J, White LE, Martin N, Yoo SS, Rademaker AW, Alam M.(PubMed)
3. Homeopathic arnica for prevention of pain and bruising: randomized placebo-controlled trial in hand surgery. by Stevinson C, Devaraj VS, Fountain-Barber A, Hawkins S, Ernst E.(Pubmed)
4. The effect of topical arnica on muscle pain" by Adkison JD, Bauer DW, Chang T., (PubMed).
5. Cosmetics and herbal remedies with Compositae plant extracts - are they tolerated by Compositae-allergic patients?" by Paulsen E, Chistensen LP, Andersen KE., (PubMed)
6. Contact allergy to Compositae plants in patients with atopic dermatitis. [Article in English, Serbian]" by Jovanović M, Poljacki M, Duran V, Vujanović L, Sente R, Stojanović S., (PubMed)
Herbal Arnica may process the property of speeding bruise healing without inducing adverse effects, some studies suggested.
A bruise is a condition characterized by black and blue marks on the skin due to trauma, caused by an object or force that strikes the body, leading to damage to capillaries and sometimes venules that allow blood to seep, hemorrhage, or extravasate into the surrounding interstitial tissues.
A bruise can also be induced by surgery caused by instruments that pierce into the deep layer of the skin to create an opening.
Most Bruising resolves itself in a few days or weeks.
Some bruises may cause pain but the pain usually goes away when the color of the area fades away.
Bruising, also known as a contusion, is defined as a condition of
Some researchers suggested that
The most common causes of bruising are sport related.
Sports physical activities can sometimes cause broken bones, strains and sprains, dislocations, torn tendons,..... and muscle swelling. Overuse of body muscles in sports is one of the risk factors that can cause, inducing bruising.
Ice and heat therapies by Appling ice or heat immediately after the injury to reduce blood flow around the area. were found to be effective in preventing bruising.
Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia.
The herb has been used in traditional medicine for centuries to treat strains, sprains, and bruises.
In the assessment of the comparative utility of topical formulations in hastening the resolution of skin bruising, researchers at Northwestern University conducted a double (patient and rater) blinded randomized controlled trial with numbers of healthy volunteers, age range 21-65 years.
After four standard bruises of 7 mm diameter each were created on the bilateral upper inner arms, 5 cm apart, two per arm, using a 595-nm pulsed-dye laser (Vbeam; Candela Corp., Wayland, MA, U.S.A.). On each subject, each bruising area was injected with one topical agent, including 5% vitamin K, 1% vitamin K, and 0·3% retinol, 20% arnica, or white petrolatum, twice a day for 2 weeks.
At the end of the 2 weeks experiment, researchers found that
* All four treatment scores a significant improvement in the change in the rater bruising score.
* The mean improvement associated with 20% arnica was greater than with white petrolatum (P=0·003), and the mixture of 1% vitamin K and 0·3% retinol.
* However, 5% vitamin K cream processes the highest bruise healing score compared to other applications.
These results suggested that topical 20% Arnica ointment may be able to reduce bruising more effectively than placebo and more effectively than low-concentration vitamin K formulations, such as 1% vitamin K with 0·3% retinol.
In a double-blind, placebo-controlled, randomized trial with three parallel arms to reaffirm Arnica efficacy in the control of bruising, reducing swelling, and promoting recovery after local trauma, 64 adults undergoing elective surgery for carpal tunnel syndrome were randomized to take three tablets daily of homeopathic Arnica 30C or 6C or placebo for seven days before surgery and fourteen days after surgery.
According to the summary of the experiment's final report, researchers showed
* There were no group differences in the primary outcome measures of pain (P=0.79) and bruising (P=0.45) on day four.
* Swelling and use of analgesic medication also did not differ between arnica and placebo groups.
* Adverse events were reported by 2 patients in the Arnica 6C group, 3 in the placebo group, and 4 in the Arnica 30C group.
These results strongly indicated that Arnica does not process analgesic properties.
Moreover, in the study to assess Arnica's decreases bruising and muscle pain efficacy, the Memorial Family Medicine Residency Program conducted a randomized, double-blind, placebo-controlled trial including 53 subjects.
Measurement of ankle range of motion and muscle tenderness were also recorded during Leg pain induced by calf raises.
Then, each participant received 2 tubes of cream, 1 with active Arnica and 1 with placebo.
The creams were applied to the lower legs immediately after the exercise, and again at 24 and 48 hours post-exercise according to the "RIGHT" or "LEFT" labels.
At 48 hours post-exercise, subjects had their ankle range of motion and muscle tenderness measured.
Subjects used the analog scale to rate pain in each leg at baseline, 24 hours, 48 hours, and 72 hours.
On the final day of the study, by analyzing the reports returned by participants, scientists found that
* No significant differences in pain scores were seen before exercise.
* Pain scores on legs treated with Arnica were higher than scores on those receiving placebo 24 hours after exercise respectively.
* Pain scores on day 3 and day 4 were not significantly different.
* There was no difference in muscle tenderness.
* Ankle range of motion did not differ significantly on either day 1 or day 3.
Dr. Adkison JD, the lead author suggested, Arnica may increase pain in the affected area within 48 hours immediately after application.
Taking all together, herbal Arnica may be used as a therapeutic treatment for speeding up bruise healing however, patients should be aware that topical application of herbal Arnica does not process analgesic properties. In some cases, it may increase pain in the affected area.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
2. Accelerated resolution of laser-induced bruising with topical 20% arnica: a rater-blinded randomized controlled trial. by Leu S, Havey J, White LE, Martin N, Yoo SS, Rademaker AW, Alam M.(PubMed)
3. Homeopathic arnica for prevention of pain and bruising: randomized placebo-controlled trial in hand surgery. by Stevinson C, Devaraj VS, Fountain-Barber A, Hawkins S, Ernst E.(Pubmed)
4. The effect of topical arnica on muscle pain" by Adkison JD, Bauer DW, Chang T., (PubMed).
5. Cosmetics and herbal remedies with Compositae plant extracts - are they tolerated by Compositae-allergic patients?" by Paulsen E, Chistensen LP, Andersen KE., (PubMed)
6. Contact allergy to Compositae plants in patients with atopic dermatitis. [Article in English, Serbian]" by Jovanović M, Poljacki M, Duran V, Vujanović L, Sente R, Stojanović S., (PubMed)
#Antioxidant #Polyphenols Found in #GreenTea Suppress the Onset and Progression of Osteoporosis in Vivos, According to Studies
By Kyle J. Norton
Green tea may have a therapeutic and positive effect in reducing the onset, progression, and treatment of osteoporosis, some scientists suggested.
Osteoporosis is a chronic condition characterized by progression in the reduction of bone mass and deterioration of bone tissue and considered a major health problem in both elderly men and women.
The diseases also affect all bone in the body, including the bones of the spine, hip, and wrist
Scientists as of today do not know the exact causes of osteoporosis. However, they do know that certain factors are associated with the onset and progression of the disease.
Osteoporosis is a common disease among the elderly, probably due to the aging effect that induces nutrition deficiency such as
* Vitamin D insufficiency and reduced calcium absorption,
* Reduced hormone production, the drop of estrogen levels after menopause, can speeds up bone loss.
* Reduced production of bone mass and increased bone reabsorption.
These results suggested that osteoporosis can make the bone more fragile and easier to break. In the elderly, osteoporosis can be dangerous, as fractures can cause prolonged immobility, and required a longer healing process.
Some researchers suggested that fractures in the older population are the most common cause of blood clots or pneumonia, both of which can have fatal consequences.
Long-term use of certain medicines, such as anti-seizure drug Glucocorticoids and medical conditions such as kidney disease, Cushing's syndrome, and an overactive thyroid or parathyroid, can also increase the risk of osteoporosis.
Dr. Stephen P Tuck, the lead author of the study Osteoporosis in men said, "The incidence of osteoporotic fractures in elderly men, just as in aged women, increases exponentially with age; the rise in men, however, is some 5–10 years later than in women. Up to 50% of male osteoporosis have no identifiable etiology; however elderly males have a much higher likelihood of having an identifiable secondary cause than younger men".
Truly, both males and females share the same conditions of the onset of osteoporosis, but the onset of the disease in men is about 10 years later, compared to a woman of the same age.
Interestingly, in the observation of hip fracture in the aging population, Dr. Eric Orwoll, a physician-researcher who studies osteoporosis at Oregon Health and Science University wrote, “A third of all hip fractures occur in men, yet the problem of osteoporosis in men is frequently downplayed or ignored.”
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
In the study to evaluate the effects of ingestion of green tea and green tea bioactive compounds in mitigating bone loss and risk of osteoporotic fractures in both elderly women and men, researchers found that the applications exert significant activities in reducing the onset of osteoporosis, through their antioxidants and initiation of the production of natural antioxidant in the body such as glutathione and enzymes (e.g., catalase and superoxide dismutase) in inhibiting the levels of ROS that facilitate the chain reaction.
Truly, the overexpression of free radicals has been associated with the change in the balance between the activities of osteoblasts and osteoclasts, leading to osteoclasts destroying the calcified tissue and inducing bone remodeling.
These results demonstrated that green tea and its bioactive components exhibit a significant decrease in the risk of fracture by improving bone mineral density and preventing free radicals in damage the bone-forming osteoblasts while suppressing osteoclastic activities.
Moreover, in the review of the effect of green tea and its bioactive components on bone health, researchers indicated that the ingestions display an impressive osteoprotective impact on bone mass and microarchitecture in various bone loss models associated with aging, sex hormone deficiency, and chronic inflammation.
The implication of reduced onset and progression of osteoporosis in the aging population due to sex hormone deficiency may be attributed to green tea and its bioactive compound in increasing the levels of osteocalcin, a bone formation marker, decreasing serum of tartrate-resistant acid phosphatase (TRAP), a bone resorption marker and improving the body in the absorption of calcium.
In fact, the serum levels of osteocalcin (OC) and tartrate-resistant acid phosphatase (TRAP) are considered effective measurements in the rate of bone turn over in patients with osteoporosis.
Interestingly, application of green tea and its bioactive compound also is found to modulate the expression of proinflammatory cytokines in the regulation of osteoblasts and osteoclasts, through inhibiting the production of C-reactive protein (CRP) in the liver in initiating inflammation and reducing levels of interleukin-1 and 6(IL-1-6) and tumor necrosis factor-alpha (TNF-α), the sensitive markers of systemic inflammation.
This differentiation was supported by the study in the evaluation of the efficacy of green tea polyphenols (GTPs) at mitigating bone loss and microstructure deterioration along with related mechanisms in 40 androgen-deficient aged male rats, a model of male osteoporosis, randomly assigned to received A 2 (sham vs. orchidectomy) × 2 (no GTP and 0.5% GTP in drinking water) for 16 weeks.
At the end of the experiment, researchers found that rats treated with GTP demonstrate increased serum osteocalcin concentrations, bone mineral density, and trabecular volume, number, and strength of femur; trabecular volume and thickness and bone formation in both the proximal tibia and periosteal tibial shaft, and decreased eroded surface in the proximal tibia and endocortical tibial shaft; and increased liver glutathione peroxidase activity.
The findings indicated a strong implication of green tea polyphenols in decreasing cortical and trabecular bone loss and increasing both bone density by stimulating the overexpression of bone formation and reducing bone resorption via antioxidant capacity.
Taken together, green tea and its bioactive polyphenols may be considered functional foods in ameliorating early-onset, progression and combined with standard medicine for the treatment of osteoporosis.
However, the intake of green tea supplements should be taken with extreme care due to recent reports of acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea and bone metabolism by Shen CL1, Yeh JK, Cao JJ, Wang JS. (PubMed)
(2) Green tea and bone health: Evidence from laboratory studies by Shen CL1, Yeh JK, Cao JJ, Chyu MC, Wang JS. (PubMed)
(3) Supplementation with green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats by Shen CL1, Cao JJ, Dagda RY, Tenner TE Jr, Chyu MC, Yeh JK. (PubMed)
(4) Osteoporosis in the aging male: Treatment option by Stephen P Tuck1 and Harish K Datta. (PubMed)
Green tea may have a therapeutic and positive effect in reducing the onset, progression, and treatment of osteoporosis, some scientists suggested.
Osteoporosis is a chronic condition characterized by progression in the reduction of bone mass and deterioration of bone tissue and considered a major health problem in both elderly men and women.
The diseases also affect all bone in the body, including the bones of the spine, hip, and wrist
Scientists as of today do not know the exact causes of osteoporosis. However, they do know that certain factors are associated with the onset and progression of the disease.
Osteoporosis is a common disease among the elderly, probably due to the aging effect that induces nutrition deficiency such as
* Vitamin D insufficiency and reduced calcium absorption,
* Reduced hormone production, the drop of estrogen levels after menopause, can speeds up bone loss.
* Reduced production of bone mass and increased bone reabsorption.
These results suggested that osteoporosis can make the bone more fragile and easier to break. In the elderly, osteoporosis can be dangerous, as fractures can cause prolonged immobility, and required a longer healing process.
Some researchers suggested that fractures in the older population are the most common cause of blood clots or pneumonia, both of which can have fatal consequences.
Long-term use of certain medicines, such as anti-seizure drug Glucocorticoids and medical conditions such as kidney disease, Cushing's syndrome, and an overactive thyroid or parathyroid, can also increase the risk of osteoporosis.
Dr. Stephen P Tuck, the lead author of the study Osteoporosis in men said, "The incidence of osteoporotic fractures in elderly men, just as in aged women, increases exponentially with age; the rise in men, however, is some 5–10 years later than in women. Up to 50% of male osteoporosis have no identifiable etiology; however elderly males have a much higher likelihood of having an identifiable secondary cause than younger men".
Truly, both males and females share the same conditions of the onset of osteoporosis, but the onset of the disease in men is about 10 years later, compared to a woman of the same age.
Interestingly, in the observation of hip fracture in the aging population, Dr. Eric Orwoll, a physician-researcher who studies osteoporosis at Oregon Health and Science University wrote, “A third of all hip fractures occur in men, yet the problem of osteoporosis in men is frequently downplayed or ignored.”
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
In the study to evaluate the effects of ingestion of green tea and green tea bioactive compounds in mitigating bone loss and risk of osteoporotic fractures in both elderly women and men, researchers found that the applications exert significant activities in reducing the onset of osteoporosis, through their antioxidants and initiation of the production of natural antioxidant in the body such as glutathione and enzymes (e.g., catalase and superoxide dismutase) in inhibiting the levels of ROS that facilitate the chain reaction.
Truly, the overexpression of free radicals has been associated with the change in the balance between the activities of osteoblasts and osteoclasts, leading to osteoclasts destroying the calcified tissue and inducing bone remodeling.
These results demonstrated that green tea and its bioactive components exhibit a significant decrease in the risk of fracture by improving bone mineral density and preventing free radicals in damage the bone-forming osteoblasts while suppressing osteoclastic activities.
Moreover, in the review of the effect of green tea and its bioactive components on bone health, researchers indicated that the ingestions display an impressive osteoprotective impact on bone mass and microarchitecture in various bone loss models associated with aging, sex hormone deficiency, and chronic inflammation.
The implication of reduced onset and progression of osteoporosis in the aging population due to sex hormone deficiency may be attributed to green tea and its bioactive compound in increasing the levels of osteocalcin, a bone formation marker, decreasing serum of tartrate-resistant acid phosphatase (TRAP), a bone resorption marker and improving the body in the absorption of calcium.
In fact, the serum levels of osteocalcin (OC) and tartrate-resistant acid phosphatase (TRAP) are considered effective measurements in the rate of bone turn over in patients with osteoporosis.
Interestingly, application of green tea and its bioactive compound also is found to modulate the expression of proinflammatory cytokines in the regulation of osteoblasts and osteoclasts, through inhibiting the production of C-reactive protein (CRP) in the liver in initiating inflammation and reducing levels of interleukin-1 and 6(IL-1-6) and tumor necrosis factor-alpha (TNF-α), the sensitive markers of systemic inflammation.
This differentiation was supported by the study in the evaluation of the efficacy of green tea polyphenols (GTPs) at mitigating bone loss and microstructure deterioration along with related mechanisms in 40 androgen-deficient aged male rats, a model of male osteoporosis, randomly assigned to received A 2 (sham vs. orchidectomy) × 2 (no GTP and 0.5% GTP in drinking water) for 16 weeks.
At the end of the experiment, researchers found that rats treated with GTP demonstrate increased serum osteocalcin concentrations, bone mineral density, and trabecular volume, number, and strength of femur; trabecular volume and thickness and bone formation in both the proximal tibia and periosteal tibial shaft, and decreased eroded surface in the proximal tibia and endocortical tibial shaft; and increased liver glutathione peroxidase activity.
The findings indicated a strong implication of green tea polyphenols in decreasing cortical and trabecular bone loss and increasing both bone density by stimulating the overexpression of bone formation and reducing bone resorption via antioxidant capacity.
Taken together, green tea and its bioactive polyphenols may be considered functional foods in ameliorating early-onset, progression and combined with standard medicine for the treatment of osteoporosis.
However, the intake of green tea supplements should be taken with extreme care due to recent reports of acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea and bone metabolism by Shen CL1, Yeh JK, Cao JJ, Wang JS. (PubMed)
(2) Green tea and bone health: Evidence from laboratory studies by Shen CL1, Yeh JK, Cao JJ, Chyu MC, Wang JS. (PubMed)
(3) Supplementation with green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats by Shen CL1, Cao JJ, Dagda RY, Tenner TE Jr, Chyu MC, Yeh JK. (PubMed)
(4) Osteoporosis in the aging male: Treatment option by Stephen P Tuck1 and Harish K Datta. (PubMed)
#Antioxidant #Andrographolide (AN) Found in #Andrographis Protects the Liver Against Damage and Injury, Studies Show
By Kyle J. Norton
Scientists may have found a herbal medicine which processes strong liver-protective effects, some studies suggested.
The hepatoprotective effect is the action of the prevention of the liver against liver damage or toxicity.
There is no single cause of liver diseases. Researchers suggested that virus such as hepatitis A, B, C, long-term excessive alcohol drinking and genetic mutation inherited from the parents is the major risk factors associated with the early onset of the diseases.
Some researchers suggested overweight and obesity and congenital diseases such as Hemochromatosis and Wilson’s disease also are the prevalent risk factors of liver damage and diseases.
Liver damage and disease can also be caused by long-term intake of certain medications, such as paracetamol and Illegal drugs such as cocaine.
In the article on liver diseases, the 24 health also include autoimmune diseases that cause inflammation to the liver.
Sadly, according to the statistic, the mortality rate infected by viral hepatitis have increased by 63% from 890,000 in 1990 to 1.45 million in 2013, according to a review of data collected in 183 countries.
Symptoms of liver diseases include persistent jaundice and gastrointestinal discomforts, abdominal pain, and swelling, leg and ankles swelling, itching, and pale color of stool.
Please check with your doctor to rule out the liver disease and damage possibility, if you are experiencing some of the above symptoms.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.
The herb has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
As of today, despite enormous advances in modern medicine, conventional medicine can only focus to reduce symptoms of liver diseases. There is no completely effective medicine that can stimulate hepatic function, offer complete protection of the organ, or help to regenerate hepatic cells.
In the finding of a natural hepatoprotective agent that can help to relieve the pressure of conventional medicine in patients with liver damage or diseases, researchers at the Vinayaka Missions University conducted a study to evaluate the liver protective activity of herbal Andrographis in liver injury in rats.
After subcutaneous injection of 50% v/v carbon tetrachloride in liquid paraffin at a dose of 3 mL/kg on alternate days for a period of 4 weeks to induce chronic liver damage, the Male Wistar rats were treated with methanol and aqueous extracts of herbal Andrographis orally at a dose of 845 mg/kg/day.
At the end of the experiment, researchers found that* Herbal Andrographis extracts demonstrate clinically significant activity in comparison to a standard drug.
* Hepatic steatosis, hydropic degeneration, and necrosis caused by the injection of the carbon tetrachloride completely disappeared in the standard and extract-treated groups.
Further analysis also discovered herbal Andrographis extracts exhibited hepatoprotective action against carbon tetrachloride-induced liver injury.
Dr. Sangameswaran B, the lead author of the final report wrote, "The present investigation established pharmacological evidence to support the folklore claim that it is used traditionally as a hepatoprotective agent".
In an additional investigation of the liver protective effect of Andrographolide (AN), a major bioactive compound isolated from herbal Andrographis, researchers at the Dr. Hari Singh Gour Central University, formulate AN herbosomes (ANH) through complexation with naturally occurring soya-phosphatidylcholine (SPC) for enhancing absorption with carbon tetrachloride inducing hepatotoxicity rat model and compared.
The ANH showed a significant liver protective effect compared to the standard drug (Silymarin).
Application of ANH in an animal model has better bioavailability than those of AN observed by the statistics in vitro absorption and hence improved hepatoprotection as compared to plain AN at an equivalent dose.
Taken together, herbal Andrographis and its bioactive ingredient Andrographolide (AN)may be considered an adjunct therapy in aiding conventional medicine in providing extra protection of the liver and treatment of liver damage and diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats.
Tatiya AU, Surana SJ, Sutar MP, Gamit NH. (PubMed)
(2) Hepatoprotective effect of leaf extracts of Andrographis lineata nees on liver damage caused by carbon tetrachloride in rats. by Sangameswaran B, Reddy TC, Jayakar B.(PubMed)
(3) Enhancement of absorption and hepatoprotective potential through soya-phosphatidylcholine-andrographolide vesicular system. by Jain PK, Khurana N, Pounikar Y, Gajbhiye A, Kharya MD. (PubMed)
Scientists may have found a herbal medicine which processes strong liver-protective effects, some studies suggested.
The hepatoprotective effect is the action of the prevention of the liver against liver damage or toxicity.
There is no single cause of liver diseases. Researchers suggested that virus such as hepatitis A, B, C, long-term excessive alcohol drinking and genetic mutation inherited from the parents is the major risk factors associated with the early onset of the diseases.
Some researchers suggested overweight and obesity and congenital diseases such as Hemochromatosis and Wilson’s disease also are the prevalent risk factors of liver damage and diseases.
Liver damage and disease can also be caused by long-term intake of certain medications, such as paracetamol and Illegal drugs such as cocaine.
In the article on liver diseases, the 24 health also include autoimmune diseases that cause inflammation to the liver.
Sadly, according to the statistic, the mortality rate infected by viral hepatitis have increased by 63% from 890,000 in 1990 to 1.45 million in 2013, according to a review of data collected in 183 countries.
Symptoms of liver diseases include persistent jaundice and gastrointestinal discomforts, abdominal pain, and swelling, leg and ankles swelling, itching, and pale color of stool.
Please check with your doctor to rule out the liver disease and damage possibility, if you are experiencing some of the above symptoms.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.
The herb has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
As of today, despite enormous advances in modern medicine, conventional medicine can only focus to reduce symptoms of liver diseases. There is no completely effective medicine that can stimulate hepatic function, offer complete protection of the organ, or help to regenerate hepatic cells.
In the finding of a natural hepatoprotective agent that can help to relieve the pressure of conventional medicine in patients with liver damage or diseases, researchers at the Vinayaka Missions University conducted a study to evaluate the liver protective activity of herbal Andrographis in liver injury in rats.
After subcutaneous injection of 50% v/v carbon tetrachloride in liquid paraffin at a dose of 3 mL/kg on alternate days for a period of 4 weeks to induce chronic liver damage, the Male Wistar rats were treated with methanol and aqueous extracts of herbal Andrographis orally at a dose of 845 mg/kg/day.
At the end of the experiment, researchers found that* Herbal Andrographis extracts demonstrate clinically significant activity in comparison to a standard drug.
* Hepatic steatosis, hydropic degeneration, and necrosis caused by the injection of the carbon tetrachloride completely disappeared in the standard and extract-treated groups.
Further analysis also discovered herbal Andrographis extracts exhibited hepatoprotective action against carbon tetrachloride-induced liver injury.
Dr. Sangameswaran B, the lead author of the final report wrote, "The present investigation established pharmacological evidence to support the folklore claim that it is used traditionally as a hepatoprotective agent".
In an additional investigation of the liver protective effect of Andrographolide (AN), a major bioactive compound isolated from herbal Andrographis, researchers at the Dr. Hari Singh Gour Central University, formulate AN herbosomes (ANH) through complexation with naturally occurring soya-phosphatidylcholine (SPC) for enhancing absorption with carbon tetrachloride inducing hepatotoxicity rat model and compared.
The ANH showed a significant liver protective effect compared to the standard drug (Silymarin).
Application of ANH in an animal model has better bioavailability than those of AN observed by the statistics in vitro absorption and hence improved hepatoprotection as compared to plain AN at an equivalent dose.
Taken together, herbal Andrographis and its bioactive ingredient Andrographolide (AN)may be considered an adjunct therapy in aiding conventional medicine in providing extra protection of the liver and treatment of liver damage and diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats.
Tatiya AU, Surana SJ, Sutar MP, Gamit NH. (PubMed)
(2) Hepatoprotective effect of leaf extracts of Andrographis lineata nees on liver damage caused by carbon tetrachloride in rats. by Sangameswaran B, Reddy TC, Jayakar B.(PubMed)
(3) Enhancement of absorption and hepatoprotective potential through soya-phosphatidylcholine-andrographolide vesicular system. by Jain PK, Khurana N, Pounikar Y, Gajbhiye A, Kharya MD. (PubMed)
Subscribe to:
Posts (Atom)