By Kyle J. Norton
Herbal Arctostaphylos uva-ursi may have a potential in the prevention and treatment of bladder cancer, some scientists suggested.
Bladder cancer is a medical and chronic condition characterized by cell growth uncontrollably and disorderly in the tissue of the bladder.
Most bladder cancer starts first on the surface of the inner lining tissue of the bladder. As the cancer progress to the advanced stage, the malignant cells can infect other healthy tissue through the circulation of blood and fluid.
Bladder cancer that spreads to other parts of the body is known as metastatic bladder cancer.
According to the statistic, every year, approximately, over 80,000 adults, including 62,380 men and 18,810 women in the United States are diagnosed with bladder cancer, causing the deaths of 12,520 men and 4,720 women.
The 5-year relative survival rate of all stages of bladder cancer is about 77%. However, the 5-year relative survival rate for people diagnosed with stage 0 of bladder cancer is about 98%,
The statistic strongly suggested, if bladder cancer is diagnosed in the early stage, it is treatable.
The exact causes of bladder cancer are unknown. However, the age of 50 and over, men, smoking, and long-term exposure to harmful chemicals are associated with an increased risk of the disease,
Some researchers suggested certain medical conditions such as diabetes, previous treatment of radiotherapy and chemotherapy, and early menopause are also some of the prevalent risk factors that may increase the early onset of bladder cancer.
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.
The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infections, kidney stones, pelvic pain, etc.
The Ingredients
It contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
In the reaffirm of traditional medicine use of herbal Arctostaphylos uva-ursi for the treatment of various types of cancer, researchers at the Chung-Ang University College of Medicine launched an investigation to examine the effects of Arbutin, glycosylated hydroquinone extracted from the bearberry plant (Arctostaphylos species) on TCCSUP human bladder carcinoma cell.
At the dose at concentrations of < 500 microg/ml, Arbutin did not exhibit any cytotoxic effects in TCCSUP cells.
In different concentrations that are higher than 500microg/ml, Arbutin significantly decreased TCCSUP cell proliferation in a time-dependent manner.
According to the cell cycle analysis, arbutin strongly disrupted the cell cycle also in a time-dependent manner.
Furthermore, arbutin led to the inactivation of the extracellular signal-regulated kinase (ERK), which is known to critically regulate cell proliferation.
The in-depth analysis also found that arbutin markedly increases the expression of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1)which is considered a key mediator of p53-dependent cell cycle arrest.
Where p53, also known as TP53, is a protein that processes a function in regulating the cell cycle division and hence functions as a tumor suppression.
Dr. Li H, the lead author, after taking into account co and confounders, said, "Arbutin inhibits TCCSUP cell proliferation via ERK inactivation and p21 up-regulation".
Abnormal activation of ERK was found in human cancer due to DNA mutation. The combination of ERK pathway inhibitors (cytostatic agents) and conventional anticancer drugs (cytotoxic agents) is an excellent basis for scientists to develop new chemotherapeutic strategies against cancer.
Taken altogether, herbal Arctostaphylos uva-ursi containing a high volume of Arbutin may be considered a functional herb for the prevention and combined with conventional medicine for the treatment of bladder cancer,
However, further data collection large example size and multi-center studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of herbal Arctostaphylos uva-ursi anti-bladder cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Arbutin inhibits TCCSUP human bladder cancer cell proliferation via up-regulation of p21 By Li H, Jeong YM, Kim SY, Kim MK, Kim DS.(PubMed)
Thursday, 8 June 2023
#Healthyfood #CranberryPhytochemicalExtracts Inhibits #BreastCancer Cells in Vitro, Researchers Say
By Kyle J. Norton
The women's breasts are made of tissues that produce milk (glandular tissue) and fat. The size of a woman's breast is totally depending on the amount of fat in the breast.
Cancer is a class of medical conditions associated with cell growth uncontrollably in the specific tissue of the gland and organ.
Breast cancer is a medical condition caused by cell growth irregularly due to the alternation of cell DNA that often begins in the cells on the surface of the inner lining of the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the advanced stage after colonizing the deeper layer tissues to form a tumor through proliferation, invasive cancer cells can travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.
The most common secondary cancers spread by primary breast cancer are bone, liver, lung, and brain cancer.
According to the statistics, in the US, approximately 268,600 new cases of invasive breast cancer will be diagnosed in 2019, along with 62,930 new cases of non-invasive (in situ) breast cancer.
The lifetime risk of getting invasive breast cancer in the North America of a woman is 1/8.
The 5 years survival rate of breast cancer diagnosed in the localized stage is 100%.
The exact causes of breast cancer are not identified. Epidemiologically, aging, genetic proposition, female gender, family history, history of pregnancy, dense breast tissue, and smoking are some of the most prevalent factors that are found in patients with the disease.
However, some researchers the investigated the risk of breast cancer in obese patients suggested that the promotion of a high-fat diet that causes increased incidences of obesity in the US may have a strongly negative impact to induce the onset of breast cancer in women.
Dr. Manuel Picon‐Ruiz, the lead scientist wrote, "Recent decades have seen an unprecedented rise in obesity, and the health impact thereof is increasingly evident. In 2014, worldwide, more than 1.9 billion adults were overweight (body mass index [BMI], 25‐29.9 kg/m2), and of these, over 600 million were obese (BMI ≥30 kg/m2)".
And, "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of cancer, researchers examined the effect of the efficacy of cranberry phytochemical extracts significantly inhibited human breast cancer MCF-7 cell.
According to the tested differentiation, at doses of 5 to 30mg/mL, cranberry phytochemical extracts induced apoptosis in MCF-7 cells in a dose-dependent manner, after exposure for 4h.
Compared to the control group, cranberry phytochemical extracts at a dose of 50mg/mL exhibited an additional 25% higher ratio of apoptotic cells to total cells.
Furthermore, at doses from 10 to 50mg/mL cranberry phytochemical extracts exerted significantly arrested MCF-7 cells at G0/G1 phase.
Moreover, A constantly increasing pattern of the G1/S index was observed in the cranberry extract treatment group compared to the decrease of the G1/S ratio of the control group between 10 and 24h treatment.
Additionally, according to the cell cycle division analysis, cranberry extracts induced cell cycle arrest in the G1/S in MCF-7 cells was approximately 6 times higher than that of the control group.
Based on the findings, researchers after taking other factors into account said," These results suggest that cranberry phytochemical extracts possess the ability to suppress the proliferation of human breast cancer MCF-7 cells, and this suppression is at least partly attributed to both the initiation of apoptosis and the G1 phase arrest".
Taken altogether, cranberry may be considered a remedy for preventing and treating breast cancer, pending confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry phytochemical extracts induce cell cycle arrest and apoptosis in human MCF-7 breast cancer cells by Sun J1, Hai Liu R. (PubMed)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., 1 Cynthia Morata‐Tarifa, Ph.D., 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, Ph.D. (PMC)
The women's breasts are made of tissues that produce milk (glandular tissue) and fat. The size of a woman's breast is totally depending on the amount of fat in the breast.
Cancer is a class of medical conditions associated with cell growth uncontrollably in the specific tissue of the gland and organ.
Breast cancer is a medical condition caused by cell growth irregularly due to the alternation of cell DNA that often begins in the cells on the surface of the inner lining of the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the advanced stage after colonizing the deeper layer tissues to form a tumor through proliferation, invasive cancer cells can travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.
The most common secondary cancers spread by primary breast cancer are bone, liver, lung, and brain cancer.
According to the statistics, in the US, approximately 268,600 new cases of invasive breast cancer will be diagnosed in 2019, along with 62,930 new cases of non-invasive (in situ) breast cancer.
The lifetime risk of getting invasive breast cancer in the North America of a woman is 1/8.
The 5 years survival rate of breast cancer diagnosed in the localized stage is 100%.
The exact causes of breast cancer are not identified. Epidemiologically, aging, genetic proposition, female gender, family history, history of pregnancy, dense breast tissue, and smoking are some of the most prevalent factors that are found in patients with the disease.
However, some researchers the investigated the risk of breast cancer in obese patients suggested that the promotion of a high-fat diet that causes increased incidences of obesity in the US may have a strongly negative impact to induce the onset of breast cancer in women.
Dr. Manuel Picon‐Ruiz, the lead scientist wrote, "Recent decades have seen an unprecedented rise in obesity, and the health impact thereof is increasingly evident. In 2014, worldwide, more than 1.9 billion adults were overweight (body mass index [BMI], 25‐29.9 kg/m2), and of these, over 600 million were obese (BMI ≥30 kg/m2)".
And, "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
On finding a potential compound for the treatment of cancer, researchers examined the effect of the efficacy of cranberry phytochemical extracts significantly inhibited human breast cancer MCF-7 cell.
According to the tested differentiation, at doses of 5 to 30mg/mL, cranberry phytochemical extracts induced apoptosis in MCF-7 cells in a dose-dependent manner, after exposure for 4h.
Compared to the control group, cranberry phytochemical extracts at a dose of 50mg/mL exhibited an additional 25% higher ratio of apoptotic cells to total cells.
Furthermore, at doses from 10 to 50mg/mL cranberry phytochemical extracts exerted significantly arrested MCF-7 cells at G0/G1 phase.
Moreover, A constantly increasing pattern of the G1/S index was observed in the cranberry extract treatment group compared to the decrease of the G1/S ratio of the control group between 10 and 24h treatment.
Additionally, according to the cell cycle division analysis, cranberry extracts induced cell cycle arrest in the G1/S in MCF-7 cells was approximately 6 times higher than that of the control group.
Based on the findings, researchers after taking other factors into account said," These results suggest that cranberry phytochemical extracts possess the ability to suppress the proliferation of human breast cancer MCF-7 cells, and this suppression is at least partly attributed to both the initiation of apoptosis and the G1 phase arrest".
Taken altogether, cranberry may be considered a remedy for preventing and treating breast cancer, pending confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cranberry phytochemical extracts induce cell cycle arrest and apoptosis in human MCF-7 breast cancer cells by Sun J1, Hai Liu R. (PubMed)
(2) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., 1 Cynthia Morata‐Tarifa, Ph.D., 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, Ph.D. (PMC)
#Herbal #Anise Kills #BreastCancer Cells in Vitro, Scientists Suggest
By Kyle J. Norton
The ability to cure breast cancer with a natural plant without inducing adverse effects is the dream that many scientists would hope to see in their lifetime. However, as of today, the hope is still a long way from reality.
Some studies suggested that herbal Anise may process a significant effect on the reduction of risk and treatment of breast cancer with no side effects.
Breast cancer is a medical and chronic condition characterized by abnormal cell growth in the breast tissues. Mose cases breast cancer begins with the alternation of DNA in the cells in the inner lining of the breast. After colonizing the entire breast in the adance stage, malignant cancers can travel a distance away to infect other healthy cells and tissue.
The exact causes of breast cancer are unknown. researchers have tried hard but still could not answer the question, of why people with the same healthy condition and genetic similarity in the same family, are susceptible to the onset of the disease, while other female siblings do not.
Some researchers suggested the risk factors associated with breast cancer should be divided into preventable and unpreventable.
The preventable risk factors are conditions that can be changed through diet and lifestyle and choice, such as physical inactivity, obesity or overweight, poor diet, chest radiation, excessive alcohol drinking, and use of hormone therapy.
Unpreventable risk factors are conditions that cannot be changed including genetic opposition, age, dense breast tissue, early menstruation, late menopause, race, and gender.
However, regardless of preventable and unpreventable risk factors associated with the onset of the disease, the risk of breast cancer is lower in women who follow a long-term healthy diet and lifestyle.
According to the National Breast cancer foundation, in all women with breast cancer, 60-70% of them have no connection to these risk factors at all, and some women with these risk factors will never develop cancer.
In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Dr. Ji Hyun Kim, the lead author in the study led by the National Cancer Center, "Dietary Factors and Female Breast Cancer Risk: A Prospective Cohort Study", said, "Grilled meat and high-cholesterol food intake and irregular eating habits may be associated with a higher risk of breast cancer".
These results indicated women who follow the Western diet with high in saturated and trans fat, red meats, processed foods are associated with substantially increased risk of breast cancer compared to women, following the traditional diet pattern.
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to Egypt and the Mediterranean region.
The popular herb has been used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, antispasmodic, carminative, digestive, expectorant, stimulant, and tonic agent to treat head-lice and mites, increase blood pressure, prevent formation of gas in the gastrointestinal tract and menstrual cramps, etc.
Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there are also rare cases that breast cancer starts in other areas of the breast.
In the concerns that genomic instability, accumulative mutations, and subsequent changes in intracellular signaling cascades may influence the development of human breast cancers, researchers at The University of Mississippi launched an investigation of the transcriptional activity of NF-kappaB measured by cell-based reporter gene assay
On epoxypseudoisoeugenol-2-methyl butyrate (EPB), a phenylpropanoid isolated from the herbal Anise exerts a significant effect in the inhibition of cell growth, cell cycle progression and apoptosis in MCF-7 (estrogen-dependent) and BT-549 (estrogen-independent) breast cancer cells, through de-activating the NF-kappaB which plays an important role in the control of transcription of DNA, cytokine production and cell survival.
EPB was also found to block the proliferation of both MCF-7 and BT-549 cells in a concentration- and time-dependent manner.
The further analysis suggested that EPB induced apoptosis by cell cycle arrest in G(1)/G(0) phase in both MCF-7 and BT 549 cells.
Dr.Ma G, the lead scientist in the final report said, "In vitro, results indicated that EPB has potential for use against both hormone-dependent and hormone-independent breast cancers and its effects seem to be mediated by inhibiting the NF-kappaB activity".
In an attempt to find food components potentially acting as selective estrogen receptor modulators SERMs for treatment of breast cancer with no side effects, the University of Athens submitted four plant aqueous extracts derived from Greek flora (Sideritis Euboea, Sideritis clandestina, Matricaria chamomilla, and Pimpinella anisum) in a series of in vitro biological assays to examine their SERM profile.
All plant extracts including Anise at a concentration range 10-100 microg/mL demonstrated a potency as of SERMs in stimulating osteoblastic cell differentiation and antiestrogenic effect on breast cancer cells without proliferative effects on cervical adenocarcinoma cells.
Additionally, the antiestrogenic effect of the plant extracts was reduced under the presence of estradiol on MCF-7 cells, which suggests the extracts may process a potential estrogen receptor-related mechanism.
Taken altogether, herbal Anise may be considered a functional food for the prevention and an adjunct therapy combined with conventional medicine for the treatment of breast cancer, pending the further confirmation of large sample size and multi-center studies.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Inhibition of NF-kappaB-mediated transcription and induction of apoptosis in human breast cancer cells by epoxypseudoisoeugenol-2-methyl butyrate by Ma G, Tabanca N, Husnu Can Baser K, Kirimer N, Pasco DS, Khan IA, Khan SI. (PubMed)
(2) Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties by Kassi E, Papoutsi Z, Fokialakis N, Messari I, Mitakou S, Moutsatsou P.(PubMed)
(3) Dietary Factors and Female Breast Cancer Risk: A Prospective Cohort Study by Ji Hyun Kim,1 Jeonghee Lee,2 So-Youn Jung,3 and Jeongseon Kim. (PMC)
The ability to cure breast cancer with a natural plant without inducing adverse effects is the dream that many scientists would hope to see in their lifetime. However, as of today, the hope is still a long way from reality.
Some studies suggested that herbal Anise may process a significant effect on the reduction of risk and treatment of breast cancer with no side effects.
Breast cancer is a medical and chronic condition characterized by abnormal cell growth in the breast tissues. Mose cases breast cancer begins with the alternation of DNA in the cells in the inner lining of the breast. After colonizing the entire breast in the adance stage, malignant cancers can travel a distance away to infect other healthy cells and tissue.
The exact causes of breast cancer are unknown. researchers have tried hard but still could not answer the question, of why people with the same healthy condition and genetic similarity in the same family, are susceptible to the onset of the disease, while other female siblings do not.
Some researchers suggested the risk factors associated with breast cancer should be divided into preventable and unpreventable.
The preventable risk factors are conditions that can be changed through diet and lifestyle and choice, such as physical inactivity, obesity or overweight, poor diet, chest radiation, excessive alcohol drinking, and use of hormone therapy.
Unpreventable risk factors are conditions that cannot be changed including genetic opposition, age, dense breast tissue, early menstruation, late menopause, race, and gender.
However, regardless of preventable and unpreventable risk factors associated with the onset of the disease, the risk of breast cancer is lower in women who follow a long-term healthy diet and lifestyle.
According to the National Breast cancer foundation, in all women with breast cancer, 60-70% of them have no connection to these risk factors at all, and some women with these risk factors will never develop cancer.
In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Dr. Ji Hyun Kim, the lead author in the study led by the National Cancer Center, "Dietary Factors and Female Breast Cancer Risk: A Prospective Cohort Study", said, "Grilled meat and high-cholesterol food intake and irregular eating habits may be associated with a higher risk of breast cancer".
These results indicated women who follow the Western diet with high in saturated and trans fat, red meats, processed foods are associated with substantially increased risk of breast cancer compared to women, following the traditional diet pattern.
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to Egypt and the Mediterranean region.
The popular herb has been used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, antispasmodic, carminative, digestive, expectorant, stimulant, and tonic agent to treat head-lice and mites, increase blood pressure, prevent formation of gas in the gastrointestinal tract and menstrual cramps, etc.
Breast cancer (malignant breast neoplasm) is cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there are also rare cases that breast cancer starts in other areas of the breast.
In the concerns that genomic instability, accumulative mutations, and subsequent changes in intracellular signaling cascades may influence the development of human breast cancers, researchers at The University of Mississippi launched an investigation of the transcriptional activity of NF-kappaB measured by cell-based reporter gene assay
On epoxypseudoisoeugenol-2-methyl butyrate (EPB), a phenylpropanoid isolated from the herbal Anise exerts a significant effect in the inhibition of cell growth, cell cycle progression and apoptosis in MCF-7 (estrogen-dependent) and BT-549 (estrogen-independent) breast cancer cells, through de-activating the NF-kappaB which plays an important role in the control of transcription of DNA, cytokine production and cell survival.
EPB was also found to block the proliferation of both MCF-7 and BT-549 cells in a concentration- and time-dependent manner.
The further analysis suggested that EPB induced apoptosis by cell cycle arrest in G(1)/G(0) phase in both MCF-7 and BT 549 cells.
Dr.Ma G, the lead scientist in the final report said, "In vitro, results indicated that EPB has potential for use against both hormone-dependent and hormone-independent breast cancers and its effects seem to be mediated by inhibiting the NF-kappaB activity".
In an attempt to find food components potentially acting as selective estrogen receptor modulators SERMs for treatment of breast cancer with no side effects, the University of Athens submitted four plant aqueous extracts derived from Greek flora (Sideritis Euboea, Sideritis clandestina, Matricaria chamomilla, and Pimpinella anisum) in a series of in vitro biological assays to examine their SERM profile.
All plant extracts including Anise at a concentration range 10-100 microg/mL demonstrated a potency as of SERMs in stimulating osteoblastic cell differentiation and antiestrogenic effect on breast cancer cells without proliferative effects on cervical adenocarcinoma cells.
Additionally, the antiestrogenic effect of the plant extracts was reduced under the presence of estradiol on MCF-7 cells, which suggests the extracts may process a potential estrogen receptor-related mechanism.
Taken altogether, herbal Anise may be considered a functional food for the prevention and an adjunct therapy combined with conventional medicine for the treatment of breast cancer, pending the further confirmation of large sample size and multi-center studies.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Inhibition of NF-kappaB-mediated transcription and induction of apoptosis in human breast cancer cells by epoxypseudoisoeugenol-2-methyl butyrate by Ma G, Tabanca N, Husnu Can Baser K, Kirimer N, Pasco DS, Khan IA, Khan SI. (PubMed)
(2) Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties by Kassi E, Papoutsi Z, Fokialakis N, Messari I, Mitakou S, Moutsatsou P.(PubMed)
(3) Dietary Factors and Female Breast Cancer Risk: A Prospective Cohort Study by Ji Hyun Kim,1 Jeonghee Lee,2 So-Youn Jung,3 and Jeongseon Kim. (PMC)
The Drugs interaction of #Greentea, #Greenteaextract (#GTE), and (-)-epigallocatechin-3-gallate (#EGCG), Scientists Find
By Kyle J. Norton
Green may have processed a drug interaction property that inhibits the effect of conventional medicine, some scientists suggested.
Drug interactions are the greatest concern of some scientists, particularly in the pharmaceutical community as these effects can potentially reduce the desired effects for the treatment of certain diseases.
Intake of some drugs together, can reduce the absorption or increase the metabolism or elimination of other drug's treatment potential.
Some drugs interaction can cause an allergic reaction from skin rash and itching to a life-threatening anaphylactic reaction.
If you are taking some drugs for the treatment of certain diseases, please make sure that you know some may interact with others.
The Havard Health in the article "7 things you can do to avoid drug interactions"(4) suggested that you
1. Know why you are taking each medication
2. Know how to take the drug
3. Fill all your prescriptions at the same pharmacy
4. Are suspicious of supplements
5. Go easy on grapefruit juice
6. Limit intake of alcohol
7. Talk to your pharmacist
Green tea is a precious drink that processed the number of health benefits known to almost everyone in Asia and the Western world.
In the review summarizes published in vitro, animal, and clinical studies investigating the effects of green tea (Camellia sinensis) extract and associated catechins on drug-metabolizing enzymes and drug transporters, researchers at the Prince Sattam Bin Abdulaziz University, Al-Kharj suggested that
* Green tea extract and its main catechin, (-)-epigallocatechin-3-gallate, to varying degrees, inhibit the activity of the cytochrome P450 superfamily of enzymes of CYP1A1, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2D6, and CYP3A4. UGT1A1 and UGT1A4 but not the major cytochrome P450 enzyme, in vitro
Where cytochrome P450 enzymes have a unique function in metabolizing potentially toxic compounds, including drugs and products of endogenous metabolism.
* In A clinical study, the organic anion transporting polypeptide 1A1 transporter with the potential role of liver transporters and bile acids is also inhibited by (-)-epigallocatechin-3-gallate while P-glycoprotein, the multidrug resistance protein 1 (MDR1) is unaffected
These results suggested that patients should be cautious that the consumption of significant amounts of green tea beverages or green tea extract may interact with the substrates of organic anion transporting polypeptide as mentioned above.
Further to investigate the effects of green tea extract (GTE) and (-)-epigallocatechin-3-gallate (EGCG) on the pharmacokinetics of a non-selective hydrophilic β-blocker nadolol, which is reported to be a substrate for several drug transporters and is not metabolized by cytochrome P450 enzymes launched a study o the. male Sprague-Dawley rats.
The tested animals were given GTE (400 mg/kg), EGCG (150 mg/kg), or saline (control) by oral gavage, 30 min before a single intragastric administration of 10 mg/kg nadolol.
At the end of the experiment, researchers showed that
* Pretreatment with GTE resulted in marked reductions in the maximum concentration (Cmax) and area under the time-plasma concentration curve (AUC) of nadolol by 85% and 74%, respectively, compared with the control.
* EGCG alone significantly reduced the Cmax and AUC of nadolol.
* The amounts of nadolol excreted into the urine were decreased by pretreatments with GTE and EGCG, while the terminal half-life of nadolol was not different among groups.
These results suggest that the coadministration with green tea catechins, particularly EGCG, causes a significant alteration in the pharmacokinetics of nadolol, possibly through the inhibition of its intestinal absorption mediated by uptake transporters.
Taken all together, green tea, green tea extract (GTE), and (-)-epigallocatechin-3-gallate (EGCG) can interact with the drug-metabolizing enzymes and drug transporters including nadolol.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of green tea extract and (-)-epigallocatechin-3-gallate on pharmacokinetics of nadolol in rats by Misaka S1, Miyazaki N, Fukushima T, Yamada S, Kimura J.(PubMed)
(2) An Appraisal of Drug-Drug Interactions with Green Tea Albassam AA1, Markowitz JS2.(PubMed)
(3) Effects of green tea extract on the pharmacokinetics of quetiapine in rats by Ezzeldin E1, Asiri YA2, Iqbal M1. (PubMed)
(4) 7 things you can do to avoid drug interactions by Harvard Health
Green may have processed a drug interaction property that inhibits the effect of conventional medicine, some scientists suggested.
Drug interactions are the greatest concern of some scientists, particularly in the pharmaceutical community as these effects can potentially reduce the desired effects for the treatment of certain diseases.
Intake of some drugs together, can reduce the absorption or increase the metabolism or elimination of other drug's treatment potential.
Some drugs interaction can cause an allergic reaction from skin rash and itching to a life-threatening anaphylactic reaction.
If you are taking some drugs for the treatment of certain diseases, please make sure that you know some may interact with others.
The Havard Health in the article "7 things you can do to avoid drug interactions"(4) suggested that you
1. Know why you are taking each medication
2. Know how to take the drug
3. Fill all your prescriptions at the same pharmacy
4. Are suspicious of supplements
5. Go easy on grapefruit juice
6. Limit intake of alcohol
7. Talk to your pharmacist
Green tea is a precious drink that processed the number of health benefits known to almost everyone in Asia and the Western world.
In the review summarizes published in vitro, animal, and clinical studies investigating the effects of green tea (Camellia sinensis) extract and associated catechins on drug-metabolizing enzymes and drug transporters, researchers at the Prince Sattam Bin Abdulaziz University, Al-Kharj suggested that
* Green tea extract and its main catechin, (-)-epigallocatechin-3-gallate, to varying degrees, inhibit the activity of the cytochrome P450 superfamily of enzymes of CYP1A1, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2D6, and CYP3A4. UGT1A1 and UGT1A4 but not the major cytochrome P450 enzyme, in vitro
Where cytochrome P450 enzymes have a unique function in metabolizing potentially toxic compounds, including drugs and products of endogenous metabolism.
* In A clinical study, the organic anion transporting polypeptide 1A1 transporter with the potential role of liver transporters and bile acids is also inhibited by (-)-epigallocatechin-3-gallate while P-glycoprotein, the multidrug resistance protein 1 (MDR1) is unaffected
These results suggested that patients should be cautious that the consumption of significant amounts of green tea beverages or green tea extract may interact with the substrates of organic anion transporting polypeptide as mentioned above.
Further to investigate the effects of green tea extract (GTE) and (-)-epigallocatechin-3-gallate (EGCG) on the pharmacokinetics of a non-selective hydrophilic β-blocker nadolol, which is reported to be a substrate for several drug transporters and is not metabolized by cytochrome P450 enzymes launched a study o the. male Sprague-Dawley rats.
The tested animals were given GTE (400 mg/kg), EGCG (150 mg/kg), or saline (control) by oral gavage, 30 min before a single intragastric administration of 10 mg/kg nadolol.
At the end of the experiment, researchers showed that
* Pretreatment with GTE resulted in marked reductions in the maximum concentration (Cmax) and area under the time-plasma concentration curve (AUC) of nadolol by 85% and 74%, respectively, compared with the control.
* EGCG alone significantly reduced the Cmax and AUC of nadolol.
* The amounts of nadolol excreted into the urine were decreased by pretreatments with GTE and EGCG, while the terminal half-life of nadolol was not different among groups.
These results suggest that the coadministration with green tea catechins, particularly EGCG, causes a significant alteration in the pharmacokinetics of nadolol, possibly through the inhibition of its intestinal absorption mediated by uptake transporters.
Taken all together, green tea, green tea extract (GTE), and (-)-epigallocatechin-3-gallate (EGCG) can interact with the drug-metabolizing enzymes and drug transporters including nadolol.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of green tea extract and (-)-epigallocatechin-3-gallate on pharmacokinetics of nadolol in rats by Misaka S1, Miyazaki N, Fukushima T, Yamada S, Kimura J.(PubMed)
(2) An Appraisal of Drug-Drug Interactions with Green Tea Albassam AA1, Markowitz JS2.(PubMed)
(3) Effects of green tea extract on the pharmacokinetics of quetiapine in rats by Ezzeldin E1, Asiri YA2, Iqbal M1. (PubMed)
(4) 7 things you can do to avoid drug interactions by Harvard Health
#Healthyfood #RedCabbage Protects the #HeartMuscles Against the Development of #HeartDiseases, According to Studies
By Kyle J. Norton
Cardioprotection is a process including the use of substances associated with the preservation of the function and viability of cardiac muscle tissue by the reintroduction of oxygenic blood flow back to the tissues.
Cardiovascular disease (CVD) is a group of conditions caused by the underlying damage of blood vessels and the heart.
More precisely, CVD can be coronary artery diseases (CAD) such as angina, myocardial infarction (commonly known as a heart attack), or stroke, depending on the location of the blockage or disruption,
According to the statistics provided by the American Heart Association, approximately 84 million people in the US live with some form of cardiovascular disease. The condition has also been found to cause the death of about 2,200 people a day.
The exact causes of CVD are not identified. however, the most prevalent factors that cause CVD are aging, family history, unhealthy diet, lack of exercise, being overweight, and smoking.
Believe it or not, most patients who suffered from CVD are also associated with atherosclerosis, a condition caused by long-term plaque build-up on artery walls, that leads to narrow arteries and reduce blood flow through the arteries to the heart.
Metabolic factors including hyperglycemia, hyperlipidemia, and hyperkalemia are the most common syndromes that have been found to promote CVD.
Where hyperglycemia, hyperlipidemia, and hyperkalemia are conditions of abnormally high levels of sugar, cholesterol, and potassium levels in the bloodstream, respectively.
Dr. Gumbiner B, the lead scientist wrote, "Risk factors for cardiovascular disease (CVD) appear to cluster in individuals, possibly because of a single, underlying metabolic disorder".
And, " Abnormal metabolic risk factors were defined as (1) an abnormal glucose value (fasting blood sugar greater than 115 mg/dl); (2) abnormal lipids (high-density lipoprotein cholesterol under 35 mg/dl in men or under 45 mg/dl in women; or low-density lipoproteins of 160 or greater; or triglycerides greater than 250 mg/dl), and (3) hypertension (blood pressure systolic above 160 mmHg; or diastolic above 90 mmHg)".
Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.
On findings of natural whole food for the prevention of cardiovascular disease, researchers examined the effects of Brassica vegetables such as red cabbage on the alleviation of experimentally induced myocardial infarction.
H2O2-induced rat neonatal cardiomyoblasts (H9c2 cells) treatment associated with cytotoxicity (48-50%) and apoptosis (57.3%), were reduced by the application of anthocyanin-rich red cabbage extract (ARCE).
Furthermore, in an isoproterenol (ISO) induced rodent model of myocardial infarction, pretreated ARCE for 30 days recorded a significant increase of heart body weight ratio as compared to the ISO-treated group.
ARCE pretreatment also prevents the effect of ISO on the induction of the depletion of enzymatic antioxidants and apoptosis.
Moreover, ISO-induced infracted areas (10%) and derangement of the myocardium were also inhibited by the pretreatment of ARCE.
Additionally, ISO-induced heart cell membrane damage and heart calcium imbalance were also attenuated by the pretreatment of ARCE.
In other words, ARCE protected heart integrity against the isoproterenol (ISO) induced damage to the heart muscle.
Based on the results, researchers wrote, "Overall this study elucidates the mechanism of ARCE mediated prevention of experimentally induced myocardial damage".
Taken altogether, red cabbage may process cardioprotective activity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anthocyanin-rich extract of Brassica oleracea L. alleviates experimentally induced myocardial infarction by Jana S1, Patel D1,2, Patel S1, Upadhyay K1, Thadani J1, Mandal R3, Das S3, Devkar R. (PubMed)
(2) Metabolic risk factors for cardiovascular disease in a working population: a retrospective cohort study by Gumbiner B1, Andresen EM, Hearne FT, Michaelson TE, Bryson M, Lednar WM, Cass R. (PubMed)
Cardioprotection is a process including the use of substances associated with the preservation of the function and viability of cardiac muscle tissue by the reintroduction of oxygenic blood flow back to the tissues.
Cardiovascular disease (CVD) is a group of conditions caused by the underlying damage of blood vessels and the heart.
More precisely, CVD can be coronary artery diseases (CAD) such as angina, myocardial infarction (commonly known as a heart attack), or stroke, depending on the location of the blockage or disruption,
According to the statistics provided by the American Heart Association, approximately 84 million people in the US live with some form of cardiovascular disease. The condition has also been found to cause the death of about 2,200 people a day.
The exact causes of CVD are not identified. however, the most prevalent factors that cause CVD are aging, family history, unhealthy diet, lack of exercise, being overweight, and smoking.
Believe it or not, most patients who suffered from CVD are also associated with atherosclerosis, a condition caused by long-term plaque build-up on artery walls, that leads to narrow arteries and reduce blood flow through the arteries to the heart.
Metabolic factors including hyperglycemia, hyperlipidemia, and hyperkalemia are the most common syndromes that have been found to promote CVD.
Where hyperglycemia, hyperlipidemia, and hyperkalemia are conditions of abnormally high levels of sugar, cholesterol, and potassium levels in the bloodstream, respectively.
Dr. Gumbiner B, the lead scientist wrote, "Risk factors for cardiovascular disease (CVD) appear to cluster in individuals, possibly because of a single, underlying metabolic disorder".
And, " Abnormal metabolic risk factors were defined as (1) an abnormal glucose value (fasting blood sugar greater than 115 mg/dl); (2) abnormal lipids (high-density lipoprotein cholesterol under 35 mg/dl in men or under 45 mg/dl in women; or low-density lipoproteins of 160 or greater; or triglycerides greater than 250 mg/dl), and (3) hypertension (blood pressure systolic above 160 mmHg; or diastolic above 90 mmHg)".
Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem with a crowded mass of leaves, usually green but in some varieties, it may be red or purplish.
On findings of natural whole food for the prevention of cardiovascular disease, researchers examined the effects of Brassica vegetables such as red cabbage on the alleviation of experimentally induced myocardial infarction.
H2O2-induced rat neonatal cardiomyoblasts (H9c2 cells) treatment associated with cytotoxicity (48-50%) and apoptosis (57.3%), were reduced by the application of anthocyanin-rich red cabbage extract (ARCE).
Furthermore, in an isoproterenol (ISO) induced rodent model of myocardial infarction, pretreated ARCE for 30 days recorded a significant increase of heart body weight ratio as compared to the ISO-treated group.
ARCE pretreatment also prevents the effect of ISO on the induction of the depletion of enzymatic antioxidants and apoptosis.
Moreover, ISO-induced infracted areas (10%) and derangement of the myocardium were also inhibited by the pretreatment of ARCE.
Additionally, ISO-induced heart cell membrane damage and heart calcium imbalance were also attenuated by the pretreatment of ARCE.
In other words, ARCE protected heart integrity against the isoproterenol (ISO) induced damage to the heart muscle.
Based on the results, researchers wrote, "Overall this study elucidates the mechanism of ARCE mediated prevention of experimentally induced myocardial damage".
Taken altogether, red cabbage may process cardioprotective activity, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anthocyanin-rich extract of Brassica oleracea L. alleviates experimentally induced myocardial infarction by Jana S1, Patel D1,2, Patel S1, Upadhyay K1, Thadani J1, Mandal R3, Das S3, Devkar R. (PubMed)
(2) Metabolic risk factors for cardiovascular disease in a working population: a retrospective cohort study by Gumbiner B1, Andresen EM, Hearne FT, Michaelson TE, Bryson M, Lednar WM, Cass R. (PubMed)
#Healthyfood #Celery Protects the Liver Against the Onset of Liver Diseases, Scientists Say
By Kyle J. Norton
Scientists may have found whole food for the prevention and treatment of liver disease without inducing any side effects, according to some studies.
Liver disease is a medical and chronic condition characterized by impeding the function of the liver.
There is no single cause of liver disease. However, certain conditions such as hepatitis virus, liver scars, and long-term intake of certain medications such as Vicodin, Norco, and statins, are associated with the onset of the disease.
The liver, one of the main organs in the human plays a critical role in the metabolism of protein such as changing amino acids in foods so that they can be absorbed to produce energy or make carbohydrates or fats, blood clotting to cholesterol, glucose, and iron metabolism.
Epidemiological studies suggested that the most common cause of liver disease in the Western world may result from excessive alcohol drinking.
According to the statistic provided on Alcohol Consumption, by Hannah Ritchie and Max Roser, the US adult drink averages around 8 to 9 liters per year.
And, the article by Linda Carroll, "(Researchers found that between 1999 and 2016, annual deaths due to cirrhosis increased by 65 percent, from 20,661 to 34,174" and "Overall, deaths due to liver cancer more than doubled, increasing from 5,112 to 11,073 annually".
These results clearly support that increased alcohol drinking in US adults is a culprit which contributes to the risk and onset of liver disease.
Sadly to find out that over nearly a decade, deaths from liver disease have been rising rapidly in the U.S., according to the article.
Celery is a species of Apium graveolens, belongings to the family Apiaceae. It is cultivated all around the globe as a vegetable. Celery can grow to 1/2 m tall with stalks (leaf on the top) arranged in a conical shape joined at a common base.
In the concern of acetaminophen (APAP)-induced liver damage, one of the most common problems among the population, researchers at the Rajalakshmi Engineering College examined the hepatoprotective effect of celery leaves on APAP-induced toxicity in freshwater fish.
The study included fish divided into four experimental groups of 6 fish each. Group 1 served as control. Group 2 fish were exposed to APAP (500 mg/kg) for 24 h. Groups 3 and 4 fish were exposed to APAP + celery leaf powder (CE) (500 mg/kg) and CE for 24 h, respectively.
Fish treated with APAP showed significant liver damage through the observation of the elevated levels of both circulating and tissue hepatotoxic markers (AST, ALT, and ALP), reduced hepatic glycogen and lipid contents (TG and cholesterol), reduced hepatic ions (Na(+), K(+) and Ca(2+)) and abnormal liver histology.
APAP treatment group also exerted an increased lipid peroxidation marker (TBARS, LHP, and PCO), an indication of oxidative stress and reduced levels of antioxidant enzymes (SOD, CAT, GPx, and GST) and non-enzymatic (GSH) antioxidants.
Furthermore, cellular thiol levels (T-SH, P-SH, and NP-SH)were also reduced in the APAP treatment group, an indication of a reduction-oxidation (redox) state against ROS.
These abnormalities associated with APAP exposure were reversed by the treatment with CE.
Additional differentiation suggested that the celery hepatoprotective effect was attributed to the presence of flavonoids such as rutein, quercetin, and luteolin.
Interestingly, the Panjab University in the study to reconfirm the traditional use of celery for the treatment of liver ailment, examine the celery antihepatotoxic effect of methanolic extracts of the seeds on rat liver damage induced by a single dose of paracetamol (3 g/kg p.o.) or thioacetamide (100 mg/kg, s.c.).
Application of the methanolic extract of the seeds demonstrated the liver protective effect by restoring liver damage caused by the injection of paracetamol (3 g/kg p.o.) or thioacetamide (100 mg/kg, s.c.), according to the monitoring of several liver function tests.
In support of the above results, Helwan University, in the study of the composition of Celery, chicory leaves, and barley grains, suggested that positive effects in decreasing the elevation of liver enzymes (aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase) and blood lipids in rat cholesterol-enriched diet.
Taken altogether, celery may be considered a functional food for the prevention and treatment of liver disease with side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(1) Hepatoprotective action of celery (Apium graveolens) leaves in acetaminophen-fed freshwater fish (Pangasius sutchi) by Shivashri C1, Rajarajeshwari T, Rajasekar P.(PubMed)
(2) Hepatoprotective activity of Apium graveolens and Hygrophila auriculata against paracetamol and thioacetamide intoxication in rats by Singh A1, Handa SS.(PubMed)
(3) Hepatoprotective effect of feeding celery leaves mixed with chicory leaves and barley grains to hypercholesterolemic rats by Abd El-Mageed NM. (PubMed)
(4) Alcohol-related liver failure deaths rising among U.S. young adults by Linda Carroll. (Reuter)
Scientists may have found whole food for the prevention and treatment of liver disease without inducing any side effects, according to some studies.
Liver disease is a medical and chronic condition characterized by impeding the function of the liver.
There is no single cause of liver disease. However, certain conditions such as hepatitis virus, liver scars, and long-term intake of certain medications such as Vicodin, Norco, and statins, are associated with the onset of the disease.
The liver, one of the main organs in the human plays a critical role in the metabolism of protein such as changing amino acids in foods so that they can be absorbed to produce energy or make carbohydrates or fats, blood clotting to cholesterol, glucose, and iron metabolism.
Epidemiological studies suggested that the most common cause of liver disease in the Western world may result from excessive alcohol drinking.
According to the statistic provided on Alcohol Consumption, by Hannah Ritchie and Max Roser, the US adult drink averages around 8 to 9 liters per year.
And, the article by Linda Carroll, "(Researchers found that between 1999 and 2016, annual deaths due to cirrhosis increased by 65 percent, from 20,661 to 34,174" and "Overall, deaths due to liver cancer more than doubled, increasing from 5,112 to 11,073 annually".
These results clearly support that increased alcohol drinking in US adults is a culprit which contributes to the risk and onset of liver disease.
Sadly to find out that over nearly a decade, deaths from liver disease have been rising rapidly in the U.S., according to the article.
Celery is a species of Apium graveolens, belongings to the family Apiaceae. It is cultivated all around the globe as a vegetable. Celery can grow to 1/2 m tall with stalks (leaf on the top) arranged in a conical shape joined at a common base.
In the concern of acetaminophen (APAP)-induced liver damage, one of the most common problems among the population, researchers at the Rajalakshmi Engineering College examined the hepatoprotective effect of celery leaves on APAP-induced toxicity in freshwater fish.
The study included fish divided into four experimental groups of 6 fish each. Group 1 served as control. Group 2 fish were exposed to APAP (500 mg/kg) for 24 h. Groups 3 and 4 fish were exposed to APAP + celery leaf powder (CE) (500 mg/kg) and CE for 24 h, respectively.
Fish treated with APAP showed significant liver damage through the observation of the elevated levels of both circulating and tissue hepatotoxic markers (AST, ALT, and ALP), reduced hepatic glycogen and lipid contents (TG and cholesterol), reduced hepatic ions (Na(+), K(+) and Ca(2+)) and abnormal liver histology.
APAP treatment group also exerted an increased lipid peroxidation marker (TBARS, LHP, and PCO), an indication of oxidative stress and reduced levels of antioxidant enzymes (SOD, CAT, GPx, and GST) and non-enzymatic (GSH) antioxidants.
Furthermore, cellular thiol levels (T-SH, P-SH, and NP-SH)were also reduced in the APAP treatment group, an indication of a reduction-oxidation (redox) state against ROS.
These abnormalities associated with APAP exposure were reversed by the treatment with CE.
Additional differentiation suggested that the celery hepatoprotective effect was attributed to the presence of flavonoids such as rutein, quercetin, and luteolin.
Interestingly, the Panjab University in the study to reconfirm the traditional use of celery for the treatment of liver ailment, examine the celery antihepatotoxic effect of methanolic extracts of the seeds on rat liver damage induced by a single dose of paracetamol (3 g/kg p.o.) or thioacetamide (100 mg/kg, s.c.).
Application of the methanolic extract of the seeds demonstrated the liver protective effect by restoring liver damage caused by the injection of paracetamol (3 g/kg p.o.) or thioacetamide (100 mg/kg, s.c.), according to the monitoring of several liver function tests.
In support of the above results, Helwan University, in the study of the composition of Celery, chicory leaves, and barley grains, suggested that positive effects in decreasing the elevation of liver enzymes (aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase) and blood lipids in rat cholesterol-enriched diet.
Taken altogether, celery may be considered a functional food for the prevention and treatment of liver disease with side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(1) Hepatoprotective action of celery (Apium graveolens) leaves in acetaminophen-fed freshwater fish (Pangasius sutchi) by Shivashri C1, Rajarajeshwari T, Rajasekar P.(PubMed)
(2) Hepatoprotective activity of Apium graveolens and Hygrophila auriculata against paracetamol and thioacetamide intoxication in rats by Singh A1, Handa SS.(PubMed)
(3) Hepatoprotective effect of feeding celery leaves mixed with chicory leaves and barley grains to hypercholesterolemic rats by Abd El-Mageed NM. (PubMed)
(4) Alcohol-related liver failure deaths rising among U.S. young adults by Linda Carroll. (Reuter)
#Healthyfood #Onion In the Promotion of Healthy Gut Microbiota, According to Studies
By Kyle J. Norton
Gut microbiota is a community of microbes living in the gastrointestinal tract, including at least 1000 different species of known bacteria with more than 3 million genes.
In a healthy individual, the ratio of good and bad microbes in the gut is balanced. However, people who have a psychological condition such as anxiety, and depression, and are under constant stress and long-term use of antibiotics, particularly your diet may have a negative impact on the ratio.
More precisely, under normal conditions, gut microbiota plays a critical role in overall health,
* Gut microbiota improves the absorption of dietary nutrients in the digestive system
* Gut microbiota protects the body against xenobiotics and drug toxicity by facilitating excretion.
* Gut microbiota also maintains the structural integrity of the gut mucosal barrier by enhancing the epithelial cells that protect the intestine against invasive pathogens and ensure the function of intestinal in nutrient adsorption.
* Gut microbiota interacts with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
However, imbalanced the ratio of gut microbiota may have a negative impact on human health and diseases.
Epidemiological studies suggested imbalanced gut microbiota dysbiosis found in overweight and obese has been found to promote diet-induced obesity and metabolic complications.
Dr. Karina Al-Ass wrote, "Obesity is a worldwide epidemiologic syndrome characterized by fat mass accumulation, mainly visceral fat. Current thinking considers the potential role of gut microbiota on the development of obesity and its related comorbidities"
And " Gut microbiota can influence energy extraction from food, lipid metabolism, immune response, and endocrine functions and its profile has shown to differ between obese and lean subjects".
A recent joint study led by the Tianjin Medical University, General Hospital, an onion supplement may be potent to improve gut microflora and intestinal histomorphology on an animal model.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
The study included a total of 300 12-day-old broiler chicks (Ross) that were randomly divided into four groups as A served as the control without any supplementation, and B, C, and D received supplemented with onion powder at the rate of 1.5, 2 and 2.5g/kg of feed respectively.
Based on the tested results,* Supplementation of onion exerted a significantly (P<0.05) increased weight gain and feed consumption compared to the control.
* Furthermore, supplementation of onion significantly inhibited the population of E. coli and increased significantly Lactobacillus and Streptococcus species.
In other words, onion supplement promotes colon health by improving the ratio of gut microbiota.
* More importantly, injection of onion supplement also significantly increases the morphometry of length, width, crypt depth, and surface area of the villus in the duodenum, jejunum, and ileum of the small intestine associated with colon health optimization.
Based on the findings, researchers said, "Onion supplementation in broiler produced a positive effect on performance, gut microflora, and intestinal histomorphology".
Taken altogether, onion processed with a higher amount of onionin A (ONA) may be considered a remedy for the promotion of colon health, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of Quercetin Monoglycosides on Oxidative Stress and Gut MicrobiotaDiversity in Mice with Dextran Sodium Sulphate-Induced Colitis by Hong Z1, Piao M. (PubMed)
(2) In vivo effects of Allium cepa L. on the selected gut microflora and intestinal histomorphology in broiler by Ur Rahman S1, Khan S1, Chand N1, Sadique U2, Khan RU. (PubMed)
(3) Gut microbiota and obesity by Karina Al-Assal, Ana Cristina Martinez, Raquel SusanaTorrinhas, Camila Cardinelli, Dan Waitzberg. (Science Direct)
Gut microbiota is a community of microbes living in the gastrointestinal tract, including at least 1000 different species of known bacteria with more than 3 million genes.
In a healthy individual, the ratio of good and bad microbes in the gut is balanced. However, people who have a psychological condition such as anxiety, and depression, and are under constant stress and long-term use of antibiotics, particularly your diet may have a negative impact on the ratio.
More precisely, under normal conditions, gut microbiota plays a critical role in overall health,
* Gut microbiota improves the absorption of dietary nutrients in the digestive system
* Gut microbiota protects the body against xenobiotics and drug toxicity by facilitating excretion.
* Gut microbiota also maintains the structural integrity of the gut mucosal barrier by enhancing the epithelial cells that protect the intestine against invasive pathogens and ensure the function of intestinal in nutrient adsorption.
* Gut microbiota interacts with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
However, imbalanced the ratio of gut microbiota may have a negative impact on human health and diseases.
Epidemiological studies suggested imbalanced gut microbiota dysbiosis found in overweight and obese has been found to promote diet-induced obesity and metabolic complications.
Dr. Karina Al-Ass wrote, "Obesity is a worldwide epidemiologic syndrome characterized by fat mass accumulation, mainly visceral fat. Current thinking considers the potential role of gut microbiota on the development of obesity and its related comorbidities"
And " Gut microbiota can influence energy extraction from food, lipid metabolism, immune response, and endocrine functions and its profile has shown to differ between obese and lean subjects".
A recent joint study led by the Tianjin Medical University, General Hospital, an onion supplement may be potent to improve gut microflora and intestinal histomorphology on an animal model.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation to garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
The study included a total of 300 12-day-old broiler chicks (Ross) that were randomly divided into four groups as A served as the control without any supplementation, and B, C, and D received supplemented with onion powder at the rate of 1.5, 2 and 2.5g/kg of feed respectively.
Based on the tested results,* Supplementation of onion exerted a significantly (P<0.05) increased weight gain and feed consumption compared to the control.
* Furthermore, supplementation of onion significantly inhibited the population of E. coli and increased significantly Lactobacillus and Streptococcus species.
In other words, onion supplement promotes colon health by improving the ratio of gut microbiota.
* More importantly, injection of onion supplement also significantly increases the morphometry of length, width, crypt depth, and surface area of the villus in the duodenum, jejunum, and ileum of the small intestine associated with colon health optimization.
Based on the findings, researchers said, "Onion supplementation in broiler produced a positive effect on performance, gut microflora, and intestinal histomorphology".
Taken altogether, onion processed with a higher amount of onionin A (ONA) may be considered a remedy for the promotion of colon health, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of Quercetin Monoglycosides on Oxidative Stress and Gut MicrobiotaDiversity in Mice with Dextran Sodium Sulphate-Induced Colitis by Hong Z1, Piao M. (PubMed)
(2) In vivo effects of Allium cepa L. on the selected gut microflora and intestinal histomorphology in broiler by Ur Rahman S1, Khan S1, Chand N1, Sadique U2, Khan RU. (PubMed)
(3) Gut microbiota and obesity by Karina Al-Assal, Ana Cristina Martinez, Raquel SusanaTorrinhas, Camila Cardinelli, Dan Waitzberg. (Science Direct)
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