By Kyle J. Norton
\Neuroprotection is an action involved in the use of a natural substance to protect the integrity of neurons against damage or death.
In other words, neuroprotection is the process to protect the brain functioning.
Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.
The most common disease associated with neurodegenerative diseases is dementia, a cluster of conditions including Parkinson’s, Alzheimer’s, and Huntington’s disease, leading to a negative influence on the body's functioning, including balance, movement, talking, breathing, and heart function.
There is no single cause of the progressive death of brain neurons. Epidemiologically, genetic preposition, and medical conditions, such as alcoholism, brain cancer, or a stroke in the brain are some of the most common prevalent factors found in patients with neurological diseases
A prolonged period of toxins and toxic chemicals accumulated that affects brain function also have a strong impact to induce the onset of the disease.
Symptoms of neurotoxicity are totally depending on the degree of toxicity. Some symptoms may take some time to develop. However, in most cases, symptoms may appear immediately after exposure.
Depending on the area and location of neuron damage, weakness or numbness, loss of memory, vision, headache change of cognitive and behavioral and sexual dysfunction are the most common symptoms found in people with neurotoxicity.
According to the WHO, neurological disorders, ranging from epilepsy to Alzheimer's disease, from stroke to headache, affect up to one billion people worldwide.
In older adults, the increase in age has been found to affect the progressive onset of neurodegenerative diseases.
Dr. Hung CW and colleagues wrote, " In the human body, it is estimated that cell division and metabolism occur exuberantly until about 25 years of age. Beyond this age, subsidiary products of metabolism and cell damage accumulate, and the phenotypes of aging appear, causing disease formation".
And, " Among these age-related diseases, neurodegenerative diseases have drawn a lot of attention due to their irreversibility, lack of effective treatment, and accompanied social and economical burdens".
Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie had large flower heads, usually green in color and the mass of flower heads is surrounded by leaves that evolved from a wild cabbage plant on the continent of Europe.
On finding a potent compound for the protection against brain disease, researchers examined the neuroprotective effect of broccoli sprouts on SH-SY5Y cells.
According to the results of the SH-SY5Y cells used in the study were treated with the fragment Aβ 25-35 by two crude juices of broccoli sprouts containing different amounts of phenolic compounds, researchers found that Aβ-induced cytotoxicity and apoptotic cell death were inhibited by the administration of both juices.
In other words, both juices protected the integrity of the neurons and inhibited the nuclear chromatin condensation and apoptotic body formation induced by Aβ injection.
The efficacy of broccoli sprout juice against the neuro-toxicity was attributed to the modulation of the mitochondrial function and the HSP70 gene transcription and expression that dissociate cytotoxic stress in the neurons.
Furthermore, oxidative stress in the brain tissues was also ameliorated by the juices by increasing the host levels of antioxidant enzymes such as heme oxygenase-1, thioredoxin, and thioredoxin reductase.
More precisely, broccoli sprout juice protected the neuron against toxicity by dissociating cytotoxic and oxidative stress.
In the comparison of the neuroprotection of 2 juices, researchers said, "Although the effects of the two juices were similar, the juice enriched in phenolic compounds showed greater efficacy in inducing the activation of the Nrf2 signaling pathway (involved in systematic inflammatory response)".
Taken altogether, broccoli sprouts may be considered a functional food for the promotion of brain health, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective Effect of Brassica oleracea Sprouts Crude Juice in a Cellular Model of Alzheimer's Disease by Masci A1, Mattioli R2, Costantino P2, Baima S3, Morelli G3, Punzi P4, Giordano C5, Pinto A1, Donini LM1, d'Erme M6, Mosca L. (PubMed)
(2) Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in Vitro and in Vivo Models of Parkinson's Disease by Morroni F1, Sita G1, Djemil A2, D'Amico M3, Pruccoli L3, Cantelli-Forti G3, Hrelia P1, Tarozzi A. (PubMed)
(3) Ageing and neurodegenerative diseases by Hung CW1, Chen YC, Hsieh WL, Chiou SH, Kao
CL. (PubMed)
Thursday, 8 June 2023
#Antioxidant 3,3'-#Diindolylmethane Shows a Significant Effect on #Melanoma, According to Studies
By Kyle J. Norton
3,3'-Diindolylmethane may be the next bioactive compound for the treatment of melanoma with no side effects, according to studies.
Melanoma is skin cancer caused by the alternation of melanocyte DNA in the skin pigment, leading to the formation of moles that change the color, size, or shape of the skin.
Most cases of melanoma start in the melanocytes or pigment-producing cells in the outer layer of the skin. However, at a later stage, the cancer cells can travel through the circulation of blood and fluids to infect other healthy cells and tissue, leading to secondary metastasis.
The liver, lungs, bones, and brain are most often affected by melanoma metastases.
According to statistics, the risk of melanoma is largely depended on race. the lifetime risk of getting melanoma is about 2.5% (1 in 40) for whites, 0.1% (1 in 1,000) for blacks, and 0.5% (1 in 200) for Hispanics.
The 5 years survival rate of melanoma is close to 100% if the disease is diagnosed in the localized stages.
In the US, every year, approximately 96,480 new melanomas are diagnosed, leading to the death of 7,000 people.
In North America, most cases of melanoma are associated with UVB exposure, causing the alteration of the cell DNA.
Dr. S A Oliveria, the lead scientist said, "Sun-sensitive phenotypes and reported sunburn were associated with an increased risk of melanoma" and "intense sun exposure is causal for melanoma in those prone to sunburn".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding a natural compound for the treatment of melanoma compared the effects of
kaempferol (Kem), genistein (Gen), and 3'3-diindolylmethane (DIM) on melanoma cell viability.
Treatment of A375SM melanoma cells with the tested phytochemicals resulted in the inhibition of cell growth.
DIM exerted strong inhibition against the A375SM melanoma cells by increasing the tumor-suppressive gene expression, p21, and decreasing the gene expression associated with the cancer cell proliferation and survival.
Injection of DIM and other tested phytochemicals also induced the expression of pro-apoptotic pathways against the tested cancer cell line and deactivated the anti-apoptotic pathways.
Furthermore, DIM and tested phytochemicals also enhanced the activity of ROS in the induction of cytotoxicity without causing harm to healthy cells.
Dr. Heo JR and colleagues said, "These results indicate that phytochemicals (kaempferol (Kem), genistein (Gen), and 3'3-diindolylmethane (DIM)) are potentially useful in treatments for melanoma due to their ability to inhibit melanoma cell growth and division".
Taken altogether, 3,3'-Diindolylmethane may be considered a supplement for the prevention and combined with primary medicine for the treatment of melanoma, pending the confirmation of a large sample size and multicenter human study.
Injection of DIM in a form of a supplement should be taken with exceptional care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phytochemical-induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis and differentiation in malignant melanoma cells by Heo JR1, Lee GA1, Kim GS1, Hwang KA1, Choi KC. (PubMed)
(2) Novel 3,3'-diindolylmethane derivatives: synthesis and cytotoxicity, structural characterization in solid state by Maciejewska D1, Rasztawicka M, Wolska I, Anuszewska E, Gruber B. (PubMed)
(3) Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate by Julia A Newton-Bishop, Yu-Mei Chang, Faye Elliott, May Chan, Susan Leake, Birute Karpavicius, Sue Haynes, Elaine Fitzgibbon, Kairen Kukalizch, Juliette Randerson-Moor, David E Elder,* D Timothy Bishop, and Jennifer H Barrett. (PMC)
3,3'-Diindolylmethane may be the next bioactive compound for the treatment of melanoma with no side effects, according to studies.
Melanoma is skin cancer caused by the alternation of melanocyte DNA in the skin pigment, leading to the formation of moles that change the color, size, or shape of the skin.
Most cases of melanoma start in the melanocytes or pigment-producing cells in the outer layer of the skin. However, at a later stage, the cancer cells can travel through the circulation of blood and fluids to infect other healthy cells and tissue, leading to secondary metastasis.
The liver, lungs, bones, and brain are most often affected by melanoma metastases.
According to statistics, the risk of melanoma is largely depended on race. the lifetime risk of getting melanoma is about 2.5% (1 in 40) for whites, 0.1% (1 in 1,000) for blacks, and 0.5% (1 in 200) for Hispanics.
The 5 years survival rate of melanoma is close to 100% if the disease is diagnosed in the localized stages.
In the US, every year, approximately 96,480 new melanomas are diagnosed, leading to the death of 7,000 people.
In North America, most cases of melanoma are associated with UVB exposure, causing the alteration of the cell DNA.
Dr. S A Oliveria, the lead scientist said, "Sun-sensitive phenotypes and reported sunburn were associated with an increased risk of melanoma" and "intense sun exposure is causal for melanoma in those prone to sunburn".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding a natural compound for the treatment of melanoma compared the effects of
kaempferol (Kem), genistein (Gen), and 3'3-diindolylmethane (DIM) on melanoma cell viability.
Treatment of A375SM melanoma cells with the tested phytochemicals resulted in the inhibition of cell growth.
DIM exerted strong inhibition against the A375SM melanoma cells by increasing the tumor-suppressive gene expression, p21, and decreasing the gene expression associated with the cancer cell proliferation and survival.
Injection of DIM and other tested phytochemicals also induced the expression of pro-apoptotic pathways against the tested cancer cell line and deactivated the anti-apoptotic pathways.
Furthermore, DIM and tested phytochemicals also enhanced the activity of ROS in the induction of cytotoxicity without causing harm to healthy cells.
Dr. Heo JR and colleagues said, "These results indicate that phytochemicals (kaempferol (Kem), genistein (Gen), and 3'3-diindolylmethane (DIM)) are potentially useful in treatments for melanoma due to their ability to inhibit melanoma cell growth and division".
Taken altogether, 3,3'-Diindolylmethane may be considered a supplement for the prevention and combined with primary medicine for the treatment of melanoma, pending the confirmation of a large sample size and multicenter human study.
Injection of DIM in a form of a supplement should be taken with exceptional care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phytochemical-induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis and differentiation in malignant melanoma cells by Heo JR1, Lee GA1, Kim GS1, Hwang KA1, Choi KC. (PubMed)
(2) Novel 3,3'-diindolylmethane derivatives: synthesis and cytotoxicity, structural characterization in solid state by Maciejewska D1, Rasztawicka M, Wolska I, Anuszewska E, Gruber B. (PubMed)
(3) Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate by Julia A Newton-Bishop, Yu-Mei Chang, Faye Elliott, May Chan, Susan Leake, Birute Karpavicius, Sue Haynes, Elaine Fitzgibbon, Kairen Kukalizch, Juliette Randerson-Moor, David E Elder,* D Timothy Bishop, and Jennifer H Barrett. (PMC)
#Alliin Found in #Garlic or #Onion, Inhibits the Parameters Associated with the Onset of Diabetes in Vivos, Researchers Suggest
By Kyle J. Norton
Diabetes is a chronic medical condition associated with the insufficiency of insulin in the bloodstream. In other words, it is the condition as a result of the body can not use insulin properly or produce enough insulin.
The condition is either caused by beta cells of the pancreas died-off or the insulin receptor sites clogged-up by fat or cholesterol.
Type I diabetes is a genetic preposition involved in the abnormal function of the immune system which mistakenly destroys the beta cells in the pancreas.
Most common symptoms of diabetes are associated with abnormally high blood sugar, leading to symptoms of unusual thirst frequent urination, weight change (gain or loss), extreme fatigue or lack of energy
In serious cases, untreated hyperglycemia in some patients may also cause symptoms of blurred vision or recurring infections due to cuts and bruises and erectile dysfunction.
According to the statistics provided by the World Health Organization, worldwide, the numbers of people with diabetes have risen at an alarming rate from 108 million in 1980 to 422 million in 2014.
The global prevalence of diabetes reached 8.5% among adults over 18 years of age in 2014, compared to only 4.7% in 1980.
The most common risk factors associated with the onset of diabetes in the US are family history, ethnicity, gender, insulin resistance, gestational diabetes, obesity, impaired glucose tolerance, women with PCOs, and aging.
However, some researchers in the concerned of the rise of diabetes over the past few decades accompanied by the widespread obesity in the US suggested that the promotion of the Western diet may have a strong effect on the induction of the condition in a population with a higher genetic risk score (GRS)
Dr. Lu Qi,, the lead scientist wrote, "A widely held hypothesis is that interactions between genetic predisposition and Western-type lifestyle contribute to the epidemic of type 2 diabetes (T2D)".
And, "intakes of processed meat, red meat, and heme iron, which characterized the Western dietary pattern, showed significant interactions with GRS in relation to diabetes risk (P for interaction = 0.029, 0.02, and 0.0004, respectively). The diet-diabetes associations were more evident among men with a high GRS (≥12) than in those with a low GRS".
In other words, if you have a high GRS accompanied by the Western diet, your risk of type II diabetes is substantially higher compared to those who have a low GRS.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find potential and natural compounds for the treatment of diabetes, researchers evaluated the preventive effect of alliin against metabolic risk factors an animal model.
The study included diet-induced obese (DIO) mice treated with drinking water with or without alliin (0.1 mg/ml) for 8 weeks.
According to the tested assays, alliin had no significant effect on the body weight, adiposity or energy balance, however, alliin treated group showed enhanced glucose homeostasis, increased insulin sensitivity, and improved lipid profile compared to control.
Further analysis of the results, researchers found that the efficacy of alliin was attributed to the modulation of the intestinal microbiota composition, typically decreased Lachnospiraceae and increased Ruminococcaceae.
Based on the findings, researchers said, "Alliin has nutraceutical or even medicinal potential in the prevention of diabetes and lipid metabolic disorders".
Furthermore, in the normal and alloxan-induced diabetic rats for five weeks, researchers compared the production and therapeutic efficiency of alliin extracted from garlic leaves of plants grown under ex-situ and in situ conditions.
According to the tested assays, serum glucose, triglycerides, total lipids, total cholesterol, low-density lipoprotein (LDL)-, and very-low-density lipoprotein (VLDL)-cholesterol in diabetic rats treated with alliin produced from in situ grown plants noted significant reduction of ~54%, 15%, 14%, 20%, 24%, and 15%, while 35%, 14%, 10%, 12%, 17%, and 11% reduction was noted in diabetic rats treated with alliin without affecting the levels of high-density lipoprotein (HDL)-cholesterol compared to other groups.
Leaf extract from plants also restored the normal levels of serum enzyme levels of alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase which were elevated in diabetic rats.
Taken altogether, alliin may be considered a supplement for the prevention and treatment of diabetes, pending the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice by Zhai B1, Zhang C1, Sheng Y1, Zhao C2, He X1,3, Xu W1,3, Huang K1,3, Luo Y. (PubMed)
(2) Alliin obtained from leaf extract of garlic grown under in situ conditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats by Nasim SA1, Dhir B, Kapoor R, Fatima S, Mahmooduzzafar, Mujib A. (PubMed)
(3) Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men by Lu Qi, Marilyn C Cornelis, Cuilin Zhang, Rob M van Dam, and Frank B Hu. (PMC)
Diabetes is a chronic medical condition associated with the insufficiency of insulin in the bloodstream. In other words, it is the condition as a result of the body can not use insulin properly or produce enough insulin.
The condition is either caused by beta cells of the pancreas died-off or the insulin receptor sites clogged-up by fat or cholesterol.
Type I diabetes is a genetic preposition involved in the abnormal function of the immune system which mistakenly destroys the beta cells in the pancreas.
Most common symptoms of diabetes are associated with abnormally high blood sugar, leading to symptoms of unusual thirst frequent urination, weight change (gain or loss), extreme fatigue or lack of energy
In serious cases, untreated hyperglycemia in some patients may also cause symptoms of blurred vision or recurring infections due to cuts and bruises and erectile dysfunction.
According to the statistics provided by the World Health Organization, worldwide, the numbers of people with diabetes have risen at an alarming rate from 108 million in 1980 to 422 million in 2014.
The global prevalence of diabetes reached 8.5% among adults over 18 years of age in 2014, compared to only 4.7% in 1980.
The most common risk factors associated with the onset of diabetes in the US are family history, ethnicity, gender, insulin resistance, gestational diabetes, obesity, impaired glucose tolerance, women with PCOs, and aging.
However, some researchers in the concerned of the rise of diabetes over the past few decades accompanied by the widespread obesity in the US suggested that the promotion of the Western diet may have a strong effect on the induction of the condition in a population with a higher genetic risk score (GRS)
Dr. Lu Qi,, the lead scientist wrote, "A widely held hypothesis is that interactions between genetic predisposition and Western-type lifestyle contribute to the epidemic of type 2 diabetes (T2D)".
And, "intakes of processed meat, red meat, and heme iron, which characterized the Western dietary pattern, showed significant interactions with GRS in relation to diabetes risk (P for interaction = 0.029, 0.02, and 0.0004, respectively). The diet-diabetes associations were more evident among men with a high GRS (≥12) than in those with a low GRS".
In other words, if you have a high GRS accompanied by the Western diet, your risk of type II diabetes is substantially higher compared to those who have a low GRS.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find potential and natural compounds for the treatment of diabetes, researchers evaluated the preventive effect of alliin against metabolic risk factors an animal model.
The study included diet-induced obese (DIO) mice treated with drinking water with or without alliin (0.1 mg/ml) for 8 weeks.
According to the tested assays, alliin had no significant effect on the body weight, adiposity or energy balance, however, alliin treated group showed enhanced glucose homeostasis, increased insulin sensitivity, and improved lipid profile compared to control.
Further analysis of the results, researchers found that the efficacy of alliin was attributed to the modulation of the intestinal microbiota composition, typically decreased Lachnospiraceae and increased Ruminococcaceae.
Based on the findings, researchers said, "Alliin has nutraceutical or even medicinal potential in the prevention of diabetes and lipid metabolic disorders".
Furthermore, in the normal and alloxan-induced diabetic rats for five weeks, researchers compared the production and therapeutic efficiency of alliin extracted from garlic leaves of plants grown under ex-situ and in situ conditions.
According to the tested assays, serum glucose, triglycerides, total lipids, total cholesterol, low-density lipoprotein (LDL)-, and very-low-density lipoprotein (VLDL)-cholesterol in diabetic rats treated with alliin produced from in situ grown plants noted significant reduction of ~54%, 15%, 14%, 20%, 24%, and 15%, while 35%, 14%, 10%, 12%, 17%, and 11% reduction was noted in diabetic rats treated with alliin without affecting the levels of high-density lipoprotein (HDL)-cholesterol compared to other groups.
Leaf extract from plants also restored the normal levels of serum enzyme levels of alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase which were elevated in diabetic rats.
Taken altogether, alliin may be considered a supplement for the prevention and treatment of diabetes, pending the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hypoglycemic and hypolipidemic effect of S-allyl-cysteine sulfoxide (alliin) in DIO mice by Zhai B1, Zhang C1, Sheng Y1, Zhao C2, He X1,3, Xu W1,3, Huang K1,3, Luo Y. (PubMed)
(2) Alliin obtained from leaf extract of garlic grown under in situ conditions possess higher therapeutic potency as analyzed in alloxan-induced diabetic rats by Nasim SA1, Dhir B, Kapoor R, Fatima S, Mahmooduzzafar, Mujib A. (PubMed)
(3) Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men by Lu Qi, Marilyn C Cornelis, Cuilin Zhang, Rob M van Dam, and Frank B Hu. (PMC)
#Healthyfood #Asparagus, Protects the Neurons Against the Development of #Depression, Scientists Say
By Kyle J. Norton
Asparagus racemosus(AR)may be beneficiary for patients with depression, a recent study conducted by Bahamas Hindu University suggested.
In an oral administration of ethanolic extract of roots of AR (MAR) of the doses of 100, 200, and 400 mg/kg daily for 7 days and then subjected to forced swim test(FST), the extract decreased immobility in FST and increased avoidance response in learned helplessness test (LH), indicating antidepressant activity.
Dr. said, " MAR has significant antidepressant activity and this effect is probably mediated through the serotonergic and the noradrenergic systems(involved neurotransmitter release in the nervous system) and augmentation of antioxidant defenses"
Asparagus is a flowering plant belonging to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, northwest Germany, northern Africa, and western Asia, used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties.
Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness. Over 30 million Americans suffer from depression and the amount is increasing at an alarming rate.
Another extract, such as Extracts of Asparagus cochinchinensis (AC) also expressed anti-depressive effects, through inhibited oxidative stress cause of neuro cell damage and improved cell signal repose and signal transmission.
Some researchers suggested that the antidepressant activity of Asparagus racemosus (AR) may also be mediated by the neurotransmitters system, and cognitive activities possibly through the cholinergic system involved neuromuscular junctions, preganglionic neurons of the sympathetic nervous system...
Furthermore, the study also showed that AR may be used as food and have potential drug-drug, drug-food, and food-food interactions with drugs and foods, sharing the cholinergic and monoaminergic pathways in sending messages between neuro cells, induced protective activities against the development of depression.
The efficacy of Asparagus in ameliorating depression through neuroprotective effect by inhibiting free radical causes of neuron cell damage and improved cell signal response and signal transmitting may require further multi and lager size studies to confirm its validity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Antidepressant activity of Asparagus racemosus in rodent models by Singh GK1, Garabadu D, Muruganandam AV, Joshi VK, Krishnamurthy S.(PubMed)
(2) The neuroprotective effects and possible mechanism of action of a methanol extract from Asparagus cochinchinensis: In vitro and in vivo studies by Jalsrai A1, Numakawa T2, Kunugi H2, Dieterich DC3, Becker A4.(PubMed)
(3) Asparagus racemosus competitively inhibits in vitro the acetylcholine and monoamine metabolizing enzymes by Meena J1, Ojha R, Muruganandam AV, Krishnamurthy S.(PubMed)
(4) Behavioural and neurochemical evaluation of Perment an herbal formulation in chronic unpredictable mild stress induced depressive model by Ramanathan M1, Balaji B, Justin A.(PubMed)
Asparagus racemosus(AR)may be beneficiary for patients with depression, a recent study conducted by Bahamas Hindu University suggested.
In an oral administration of ethanolic extract of roots of AR (MAR) of the doses of 100, 200, and 400 mg/kg daily for 7 days and then subjected to forced swim test(FST), the extract decreased immobility in FST and increased avoidance response in learned helplessness test (LH), indicating antidepressant activity.
Dr. said, " MAR has significant antidepressant activity and this effect is probably mediated through the serotonergic and the noradrenergic systems(involved neurotransmitter release in the nervous system) and augmentation of antioxidant defenses"
Asparagus is a flowering plant belonging to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, northwest Germany, northern Africa, and western Asia, used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties.
Depression is a normal response as part of our daily lives such as the loss of s job, the death of a loved one, and illness. Over 30 million Americans suffer from depression and the amount is increasing at an alarming rate.
Another extract, such as Extracts of Asparagus cochinchinensis (AC) also expressed anti-depressive effects, through inhibited oxidative stress cause of neuro cell damage and improved cell signal repose and signal transmission.
Some researchers suggested that the antidepressant activity of Asparagus racemosus (AR) may also be mediated by the neurotransmitters system, and cognitive activities possibly through the cholinergic system involved neuromuscular junctions, preganglionic neurons of the sympathetic nervous system...
Furthermore, the study also showed that AR may be used as food and have potential drug-drug, drug-food, and food-food interactions with drugs and foods, sharing the cholinergic and monoaminergic pathways in sending messages between neuro cells, induced protective activities against the development of depression.
The efficacy of Asparagus in ameliorating depression through neuroprotective effect by inhibiting free radical causes of neuron cell damage and improved cell signal response and signal transmitting may require further multi and lager size studies to confirm its validity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Antidepressant activity of Asparagus racemosus in rodent models by Singh GK1, Garabadu D, Muruganandam AV, Joshi VK, Krishnamurthy S.(PubMed)
(2) The neuroprotective effects and possible mechanism of action of a methanol extract from Asparagus cochinchinensis: In vitro and in vivo studies by Jalsrai A1, Numakawa T2, Kunugi H2, Dieterich DC3, Becker A4.(PubMed)
(3) Asparagus racemosus competitively inhibits in vitro the acetylcholine and monoamine metabolizing enzymes by Meena J1, Ojha R, Muruganandam AV, Krishnamurthy S.(PubMed)
(4) Behavioural and neurochemical evaluation of Perment an herbal formulation in chronic unpredictable mild stress induced depressive model by Ramanathan M1, Balaji B, Justin A.(PubMed)
#Healthyfood #NavyBean Inhibits the Risk of Large Intestines' Colitis Through Antiinflammatory Actvities, Researchers Say
By Kyle J. Norton
Colitis is medical a condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.
Depending on the causes, colitis can be classified into microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis, particularly in those associated with inflammatory bowel disease (IBD), such as ulcerative colitis (UC).
* Inflammatory bowel disease (IBD) is the inflammation of chronic inflammation of the digestive tract associated with symptoms of severe diarrhea, abdominal pain, fatigue, and weight loss.
* Microscopic colitis is a disease involved in the inflammation of the colon or large intestine, associated with symptoms of watery diarrhea and cramping. Microscopic colitis is much less severe than other types of inflammatory bowel disease.
* Ischemic colitis is an inflammation of the large intestine caused by the injury-induced inadequate blood supply to the colon, leading to pain on the left side of the abdomen.
* Segmental colitis associated with diverticula is an inflammation that affects colonic luminal mucosa in segments due to diverticulosis, causing symptoms of bloody stools, sometimes accompanied by abdominal pain, cramping discomfort, or diarrhea.
* Radiation colitis is an inflammation of the large intestines in patients with radiation therapy, leading to symptoms of diarrhea, nausea, vomiting and stomach cramps.
* Diversion colitis is an inflammation of the large intestines as a complication of ileostomy or colostomy. Most cases of diversion colitis often occur within the year following the surgery.
* Eosinophilic colitis is a rare disease associated with a type of white blood cell, due to injury and inflammation to the large intestine.
* Behcet's colitis is chronic immune-mediated, inflammatory disorders that only affect the intestines but also the joints, skin, eyes, and biliary tracts.
The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.
On finding a natural compound for the protection of digestive function, researchers examined the black and navy beans' effects within the colon that improve gut health and mitigate the severity of colitis-associated inflammatory pathology.
The study included C57Bl/6 mice pre-fed isocaloric 20% cooked navy bean (NB) or black bean (BB) diets for 3 weeks then switched to control basal diet (BD) 24 h prior to colitis induction via 5-day exposure to dextran sodium sulfate (2% w/v in drinking water)+3 days of freshwater.
According to the observation of the inflammatory transcription factors, such as NFκB, and STAT3, black and navy beans pre-fed showed a significant effect on the reduced severity of the acute colitis phenotype.
The levels of inflammatory mediators levels in the colon such as IL-1β, IL-6, IL-18, and MCP-1 were also lowered in the black and navy bean pre-fed groups compared to control.
Furthermore, the levels of biomarkers that enhanced wound repair responses were increased by bean prefeeding groups.
Moreover, black and navy beans pre-fed group not only also normalized the colonic epithelial function but also promoted epithelial barrier integrity, defense and/or restitution and wound closure compared to the control.
Based on the findings, Dr. Monk JM, the lead scientist wrote, "Collectively, bean supplementation prior to colitis induction (i.e., mimicking disease relapse) primes the colonic microenvironment to attenuate the severity of the colitis inflammatory phenotype and maintain aspects of epithelial barrier function".
Taken altogether, the navy bean may be considered a remedy for the prevention and treatment of colitis, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Navy and black bean supplementation attenuates colitis-associated inflammation and colonic epithelial damage by Monk JM1, Wu W2, Hutchinson AL3, Pauls P4, Robinson LE3, Power KA. (PMC)
(2) Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis by Zhang C1, Monk JM1, Lu JT1, Zarepoor L1, Wu W1, Liu R1, Pauls KP2, Wood GA3, Robinson L4, Tsao R1, Power KA. (PubMed)
Colitis is medical a condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.
Depending on the causes, colitis can be classified into microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis, particularly in those associated with inflammatory bowel disease (IBD), such as ulcerative colitis (UC).
* Inflammatory bowel disease (IBD) is the inflammation of chronic inflammation of the digestive tract associated with symptoms of severe diarrhea, abdominal pain, fatigue, and weight loss.
* Microscopic colitis is a disease involved in the inflammation of the colon or large intestine, associated with symptoms of watery diarrhea and cramping. Microscopic colitis is much less severe than other types of inflammatory bowel disease.
* Ischemic colitis is an inflammation of the large intestine caused by the injury-induced inadequate blood supply to the colon, leading to pain on the left side of the abdomen.
* Segmental colitis associated with diverticula is an inflammation that affects colonic luminal mucosa in segments due to diverticulosis, causing symptoms of bloody stools, sometimes accompanied by abdominal pain, cramping discomfort, or diarrhea.
* Radiation colitis is an inflammation of the large intestines in patients with radiation therapy, leading to symptoms of diarrhea, nausea, vomiting and stomach cramps.
* Diversion colitis is an inflammation of the large intestines as a complication of ileostomy or colostomy. Most cases of diversion colitis often occur within the year following the surgery.
* Eosinophilic colitis is a rare disease associated with a type of white blood cell, due to injury and inflammation to the large intestine.
* Behcet's colitis is chronic immune-mediated, inflammatory disorders that only affect the intestines but also the joints, skin, eyes, and biliary tracts.
The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.
On finding a natural compound for the protection of digestive function, researchers examined the black and navy beans' effects within the colon that improve gut health and mitigate the severity of colitis-associated inflammatory pathology.
The study included C57Bl/6 mice pre-fed isocaloric 20% cooked navy bean (NB) or black bean (BB) diets for 3 weeks then switched to control basal diet (BD) 24 h prior to colitis induction via 5-day exposure to dextran sodium sulfate (2% w/v in drinking water)+3 days of freshwater.
According to the observation of the inflammatory transcription factors, such as NFκB, and STAT3, black and navy beans pre-fed showed a significant effect on the reduced severity of the acute colitis phenotype.
The levels of inflammatory mediators levels in the colon such as IL-1β, IL-6, IL-18, and MCP-1 were also lowered in the black and navy bean pre-fed groups compared to control.
Furthermore, the levels of biomarkers that enhanced wound repair responses were increased by bean prefeeding groups.
Moreover, black and navy beans pre-fed group not only also normalized the colonic epithelial function but also promoted epithelial barrier integrity, defense and/or restitution and wound closure compared to the control.
Based on the findings, Dr. Monk JM, the lead scientist wrote, "Collectively, bean supplementation prior to colitis induction (i.e., mimicking disease relapse) primes the colonic microenvironment to attenuate the severity of the colitis inflammatory phenotype and maintain aspects of epithelial barrier function".
Taken altogether, the navy bean may be considered a remedy for the prevention and treatment of colitis, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Navy and black bean supplementation attenuates colitis-associated inflammation and colonic epithelial damage by Monk JM1, Wu W2, Hutchinson AL3, Pauls P4, Robinson LE3, Power KA. (PMC)
(2) Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis by Zhang C1, Monk JM1, Lu JT1, Zarepoor L1, Wu W1, Liu R1, Pauls KP2, Wood GA3, Robinson L4, Tsao R1, Power KA. (PubMed)
#Healthyfood #Lentils Improve the Parameters Associated with Reducing the Risk of #Hypertension
By Kyle J. Norton
Intake of lentils regularly and daily may have a profound and therapeutic effect in reduced risk and treatment of high blood pressure, some scientists postulated.
Lentil, a type of pulse and tiny legume that can be cooked quickly and is rich in protein and fiber is a bushy annual plant of genus Lens belongings to the Fabaceae family, native to the Middle East.
Hypertension is a chronic medical condition characterized by abnormally high blood pressure.
The study to evaluate the lentil intake activity and risk of hypertension in spontaneously hypertensive rats (SHRs) model by feeding a semi-purified diet prepared with powder (30 %, w/w) from cooked whole pulses or a pulse-free control diet (n = 8/group) for 4 weeks showed that urine samples collected from rats fed with lentil pulse group reveal 27 different metabolites in compared only 7 in control diet rat group.
According to the differentiated assays, metabolites citrulline found in the pulse group exerted a significant effect on blood pressure regulation via the production of the vasodilator nitric oxide (NO) whose bioavailability, is an important risk factor for reduced hypertension through arterial dilation by relaxing narrowed blood vessels and increasing oxygen and blood flow.
Further analysis, also discovered that several arginine-related compounds of NO synthase substrates and NO synthase arginine-based inhibitors with the same function in reduced high blood pressure expression were also detected in lentils but not in rat fed with a control diet or other pulse powders.
Dr. Hanson M, the lead author, after taking into account other confounders said, "Consumption of lentils increases the availability of arginine and several related compounds that could potentially elevate the production of NO and contribute to the blood-pressure-lowering effects of lentil-rich diets".
Additionally, examination of the effect of lentils on arterial function in relation to arterial stiffness, lipid biochemistry, and activation of select aortic proteins on 17-week-old male SHRs randomly assigned to groups (n=10/group) fed (a) 30% w/w green lentils, (b) 30% red lentils, (c) 30% mixed lentils (red and green) or (d) no lentils for 8 weeks with normotensive Wistar Kyoto (WKY) groups (n=10/group) received either the mixed lentil or no lentil diet found that group fed with red lentils expressed the greatest effect in lowering low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in compared to WKY mixed lentil groups compared to their controls.
The lentil diets group exhibited a reduced median lumen ratio in SHRs which is one of the indications for detecting hypertension in compared control-fed SHRs but not on WKYs and the red and green lentils reduced arterial stiffness of SHRs but not WKYs.
SHR lentil groups also suppressed the aortic p38 mitogen-activated protein kinase (p38MAPK) phosphorylation function in regulated vasoconstriction, thus inducing vaso-relaxation and attenuating hypertension.
Taken together, lentils with different colors may be considered a functional food in reduced risk and treatment of high blood pressure without inducing any intolerant side effects. People with a high risk of hypertension may consider adding a portion of lentils into their diet for preventive measures.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Lentil-based diets attenuate hypertension and large-artery remodeling in spontaneously hypertensive rats by Hanson MG1, Zahradka P1, Taylor CG1. (PubMed)
(2) Lentil consumption reduces resistance artery remodeling and restores arterial compliance in the spontaneously hypertensive rats by Hanson MG1, Taylor CG2, Wu Y3, Anderson HD4, Zahradka P5. (PubMed)
(3) Identification of urinary metabolites with potential blood pressure-lowering effects in lentil-fed spontaneously hypertensive rats by Hanson M1,2, Zahradka P1,3,2, Taylor CG1,3,2, Aliani M4,5.(PubMed)
Intake of lentils regularly and daily may have a profound and therapeutic effect in reduced risk and treatment of high blood pressure, some scientists postulated.
Lentil, a type of pulse and tiny legume that can be cooked quickly and is rich in protein and fiber is a bushy annual plant of genus Lens belongings to the Fabaceae family, native to the Middle East.
Hypertension is a chronic medical condition characterized by abnormally high blood pressure.
The study to evaluate the lentil intake activity and risk of hypertension in spontaneously hypertensive rats (SHRs) model by feeding a semi-purified diet prepared with powder (30 %, w/w) from cooked whole pulses or a pulse-free control diet (n = 8/group) for 4 weeks showed that urine samples collected from rats fed with lentil pulse group reveal 27 different metabolites in compared only 7 in control diet rat group.
According to the differentiated assays, metabolites citrulline found in the pulse group exerted a significant effect on blood pressure regulation via the production of the vasodilator nitric oxide (NO) whose bioavailability, is an important risk factor for reduced hypertension through arterial dilation by relaxing narrowed blood vessels and increasing oxygen and blood flow.
Further analysis, also discovered that several arginine-related compounds of NO synthase substrates and NO synthase arginine-based inhibitors with the same function in reduced high blood pressure expression were also detected in lentils but not in rat fed with a control diet or other pulse powders.
Dr. Hanson M, the lead author, after taking into account other confounders said, "Consumption of lentils increases the availability of arginine and several related compounds that could potentially elevate the production of NO and contribute to the blood-pressure-lowering effects of lentil-rich diets".
Additionally, examination of the effect of lentils on arterial function in relation to arterial stiffness, lipid biochemistry, and activation of select aortic proteins on 17-week-old male SHRs randomly assigned to groups (n=10/group) fed (a) 30% w/w green lentils, (b) 30% red lentils, (c) 30% mixed lentils (red and green) or (d) no lentils for 8 weeks with normotensive Wistar Kyoto (WKY) groups (n=10/group) received either the mixed lentil or no lentil diet found that group fed with red lentils expressed the greatest effect in lowering low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in compared to WKY mixed lentil groups compared to their controls.
The lentil diets group exhibited a reduced median lumen ratio in SHRs which is one of the indications for detecting hypertension in compared control-fed SHRs but not on WKYs and the red and green lentils reduced arterial stiffness of SHRs but not WKYs.
SHR lentil groups also suppressed the aortic p38 mitogen-activated protein kinase (p38MAPK) phosphorylation function in regulated vasoconstriction, thus inducing vaso-relaxation and attenuating hypertension.
Taken together, lentils with different colors may be considered a functional food in reduced risk and treatment of high blood pressure without inducing any intolerant side effects. People with a high risk of hypertension may consider adding a portion of lentils into their diet for preventive measures.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Lentil-based diets attenuate hypertension and large-artery remodeling in spontaneously hypertensive rats by Hanson MG1, Zahradka P1, Taylor CG1. (PubMed)
(2) Lentil consumption reduces resistance artery remodeling and restores arterial compliance in the spontaneously hypertensive rats by Hanson MG1, Taylor CG2, Wu Y3, Anderson HD4, Zahradka P5. (PubMed)
(3) Identification of urinary metabolites with potential blood pressure-lowering effects in lentil-fed spontaneously hypertensive rats by Hanson M1,2, Zahradka P1,3,2, Taylor CG1,3,2, Aliani M4,5.(PubMed)
#Antioxidant #Curcumin Found in #Turmeric Protects the Neurons Against Memory Deficit, Researchers Find
By Kyle J. Norton
Memory impairment is a condition associated with a slow decline in memory, thinking, and reasoning skills. Over time, the condition can worsen enough to affect the quality of life and daily activity.
Memory loss frequently is an early sign of memory deficit. Many factors can cause memory change. However, memory impairment in the elderly in most cases is associated with a gradual loss and death of neurons such as Alzheimer's disease.
Some memory changes can be resolved on their own or cured by medical treatment if the underlining cause is found. However, loss or gradual loss of neuron capacity cannot be revered such as dementia.
According to statistics, in the US, approximately 5.7 million people are living with dementia. The most common form of dementia is Alzheimer's disease, affecting 5.5 million people of all ages.
The most common risk factor associated with memory deficit is increasing age, smoking the genetic preposition of APOE-e4, also linked to Alzheimer's disease, obesity, and medical conditions such as diabetes, high blood pressure and depression, and physical inactivity.
Out of many risk factors, aging may be one of the major culprits that cause memory deficits in large numbers of older adults, leading to irreversible memory impairment such as AD and PD.
Dr. Gary W Small, said, "Memory changes cause concern to many patients as they grow older.". However, there are some factors that can decrease the progression of the condition, including stress reduction, physical and mental activity, healthy diet, and lifestyle choice.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
On findings a potential compound that processes anti-neuro-degeneration, researchers examined the effects of curcumin on the early stage amnesia of AD related to memory retrieval deficit.
Selected Male NMRI mice (20-25 g body weight) included in the study were treated with 50 or 100 mg/kg/po curcumin or its vehicle for 10 days. During the experiment, the animals were trained in passive avoidance apparatus ar days 10 and 30 min. before the retention test that performs after 24 hours of curcumin or its vehicle application, scopolamine (1 mg/kg/i.p.) or its vehicle was administrated.
According to the tested analysis, curcumin treatment at 50 and 100 mg/kg doses not only inhibited the activity of scopolamine in the induction of memory retrieval deficit but also restored Akt and GSK dephosphorylation associated with neuroprotection against scopolamine.
In other words, curcumin at the tested concentration effectively protect the Akt and GSK pathways which play a critical role in enhancing cell survival by stimulating cell proliferation and inhibiting apoptosis caused by scopolamine in the brain.
After taking others into account, Dr. Lv KJ, wrote in the final report, "Pre-test scopolamine administration disrupts memory retrieval along with the diminished Akt and GSK-3β phosphorylation in the hippocampus while curcumin administration prevented those changes."
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of memory retrieval deficit, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Turmeric (Curcuma longa L.) extract may prevent the deterioration of spatial memory and the deficit of the estimated total number of hippocampal pyramidal cells of trimethyl tin-exposed rats by Yuliani S1, Mustofa2, Partadiredja G. (PubMed)
(2) Curcumin ameliorates scopolamine-induced mice memory retrieval deficit and restores hippocampal p-Akt and p-GSK-3β by SoukhakLari R1, Moezi L2, Pirsalami F3, Ashjazadeh N4, Moosavi M. (PubMed)
(3) What we need to know about age related memory loss by Gary W Small, Parlow-Solomon professor on aging. (PMC)
Memory impairment is a condition associated with a slow decline in memory, thinking, and reasoning skills. Over time, the condition can worsen enough to affect the quality of life and daily activity.
Memory loss frequently is an early sign of memory deficit. Many factors can cause memory change. However, memory impairment in the elderly in most cases is associated with a gradual loss and death of neurons such as Alzheimer's disease.
Some memory changes can be resolved on their own or cured by medical treatment if the underlining cause is found. However, loss or gradual loss of neuron capacity cannot be revered such as dementia.
According to statistics, in the US, approximately 5.7 million people are living with dementia. The most common form of dementia is Alzheimer's disease, affecting 5.5 million people of all ages.
The most common risk factor associated with memory deficit is increasing age, smoking the genetic preposition of APOE-e4, also linked to Alzheimer's disease, obesity, and medical conditions such as diabetes, high blood pressure and depression, and physical inactivity.
Out of many risk factors, aging may be one of the major culprits that cause memory deficits in large numbers of older adults, leading to irreversible memory impairment such as AD and PD.
Dr. Gary W Small, said, "Memory changes cause concern to many patients as they grow older.". However, there are some factors that can decrease the progression of the condition, including stress reduction, physical and mental activity, healthy diet, and lifestyle choice.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
On findings a potential compound that processes anti-neuro-degeneration, researchers examined the effects of curcumin on the early stage amnesia of AD related to memory retrieval deficit.
Selected Male NMRI mice (20-25 g body weight) included in the study were treated with 50 or 100 mg/kg/po curcumin or its vehicle for 10 days. During the experiment, the animals were trained in passive avoidance apparatus ar days 10 and 30 min. before the retention test that performs after 24 hours of curcumin or its vehicle application, scopolamine (1 mg/kg/i.p.) or its vehicle was administrated.
According to the tested analysis, curcumin treatment at 50 and 100 mg/kg doses not only inhibited the activity of scopolamine in the induction of memory retrieval deficit but also restored Akt and GSK dephosphorylation associated with neuroprotection against scopolamine.
In other words, curcumin at the tested concentration effectively protect the Akt and GSK pathways which play a critical role in enhancing cell survival by stimulating cell proliferation and inhibiting apoptosis caused by scopolamine in the brain.
After taking others into account, Dr. Lv KJ, wrote in the final report, "Pre-test scopolamine administration disrupts memory retrieval along with the diminished Akt and GSK-3β phosphorylation in the hippocampus while curcumin administration prevented those changes."
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of memory retrieval deficit, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Turmeric (Curcuma longa L.) extract may prevent the deterioration of spatial memory and the deficit of the estimated total number of hippocampal pyramidal cells of trimethyl tin-exposed rats by Yuliani S1, Mustofa2, Partadiredja G. (PubMed)
(2) Curcumin ameliorates scopolamine-induced mice memory retrieval deficit and restores hippocampal p-Akt and p-GSK-3β by SoukhakLari R1, Moezi L2, Pirsalami F3, Ashjazadeh N4, Moosavi M. (PubMed)
(3) What we need to know about age related memory loss by Gary W Small, Parlow-Solomon professor on aging. (PMC)
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