By Kyle J. Norton
Scientists may have found a bioactive ingredient that protects the endocrine system integrity with no side effects, according to studies.
The endocrine system is made up of glands that produce and secrete hormones with the aim to regulate the activity of cells or organs.
In other words, the endocrine system produces hormones to regulate the body's growth, metabolism (the physical and chemical processes of the body), and sexual development and function.
Any disruption of the endocrine system can cause abnormal production of hormones, leading to developmental malformations in the infant and children, interference with the function of the reproductive organ, increased cancer risk; and disturbances in the immune and nervous system function.
The most common cause of endocrine dysfunction is exposure to men-made xenochemiclas. Particularly to those new and without testing men make chemicals introduced to the market every year.
There are many ways that endocrine disruptors can interfere with the endocrine system in hormone production such as mimic or partly mimicking naturally occurring hormones in the body like estrogens such as xanophytochemicals that bind to a receptor within a cell and block the endogenous hormone from binding.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural ingredient that promotes endocrine function, researchers examined the effects of ginger and turmeric on the modulation of hormone production in the body's glands.
According to the differentiation of physiological and therapeutic effects of ginger and turmeric, both exerted a significant activity in some endocrine gland functions and signal pathways by
* Inhibiting the high levels of some hormones such as T4, leptin, or interacting with hormone receptors. In other words, ginger and turmeric normalize the levels of the hormone for the body's needs.
* Inhibiting the production of cytokines/adipokine expression associated with inflammation and oxidative stress.
* Inhibiting the levels of reactive oxygen species (ROS)-generating enzymes against the oxidative stress-induced hormone imbalance.
* Protecting the cell integrity against DNA alternation by promoting pro-apoptotic and inhibiting proliferative genes.
The results strongly suggested that ginger and curcumin exerted strong protection of endocrine functioning by modulating the hormones produced by the glands.
Based on the findings, researchers said, "These multiple mechanisms of protection against inflammation and oxidative damage make ginger and curcumin particularly promising natural agents in fighting the ravages of aging and degenerative diseases".
Taken altogether, turmeric combined with ginger may be considered supplements for preventing and treating endocrine dysfunction, pending confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Physiological and therapeutical roles of ginger and turmeric on endocrine functions by Al-Suhaimi EA1, Al-Riziza NA, Al-Essa RA. (PubMed)
(2) [Effect of 5 warm-hot nature Chinese drugs for promoting blood circulation and removing blood stasis on 5-HT, NE, and endocrine hormones of rats of cold coagulation and blood stasis syndrome].[Article in Chinese] by Wang P1, Fu XJ, Zhou Y, Wang ZG. (PubMed)
Thursday, 8 June 2023
#Herbal #AloeVeraLeafGelExtract Maybe Useful for the Treatment of Type II #Diabetes, Scientist Find
By Kyle J. Norton
Scientists may have found a natural whole food for the treatment of type II diabetes without inducing any side effects, some studies suggested,
Type II diabetes is a chronic acquired medical condition characterized by insufficient insulin entering the bloodstream to regulate glucose.
The disease is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
The exact cause of type II diabetes is unknown. However, some researchers suggested that the condition is most likely caused by genetic mutation and an unhealthy lifestyle.
Other risk factors associated with the early onset of type II diabetes include overweight or obese, age 45 or older, family history, ethnicity, Alaska Native, high blood pressure and cholesterol, and women with polycystic ovary syndrome.
Dr. Waqas Sami, the lead author in the study "Effect of diet on type 2 diabetes mellitus: A review" wrote. "Dietary habits and sedentary lifestyle are the major factors for the rapidly rising incidence of DM among developing countries. In type 2 diabetics, recently, the elevated HbA1c level has also been considered as one of the leading risk factors for developing microvascular and macrovascular complications" and "Improvement in the elevated HbA1c level can be achieved through diet management; thus, the patients could be prevented from developing the diabetes complications. Awareness about diabetes complications and consequent improvement in dietary knowledge, attitude, and practices lead to better control of the disease".
These results suggested changes in diet and lifestyle are the most effective method in the management of type II diabetes.
Medication including Alpha-glucosidase inhibitors. Thiazolidinediones (TZDs) Glucagonlike peptide–1 (GLP-1) agonists. Dipeptidyl peptidase IV (DPP-4) inhibitors used for the treatment of type II diabetes may be effective, however, they are known to induce serious side effects such as low blood sugar, upset stomach, skin rash or itching, and weight gain. kidney complications, upset stomach, tiredness or dizziness,... and metal taste.
If you are currently taking one of the above medicine, please make sure that you discuss the side effects with your doctor and know how to deal with them.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan.
Herbal medicine has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of diseases, including wounds, burn healing, minor skin infections, sebaceous cysts, diabetes, elevated cholesterol, etc.
The Chemical ingredients
The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharides, polysaccharides, salicylic acids, saponins, and sterols.
In the study to examine the clinical effectiveness of aloe vera, a popular herbal remedy in the United Kingdom for the treatment of type II diabetes, researchers at the University of Exeter, launched a review by researching the database of MEDLINE, EMBASE, Biosis, and the Cochrane Library.
Only controlled clinical trials (on any indication) were included in the study.
There were no restrictions on the language of publication. All trials were read and data were extracted in a standardized, pre-defined manner.
After differentiating the 10 selected studies, researchers found that oral administration of aloe vera might be a useful adjunct for lowering blood glucose in diabetic patients as well as for reducing blood lipid levels in patients with hyperlipidemia.
However, the topical application of aloe vera was not an effective preventative for radiation-induced injuries.
Furthermore, Dr. Okyar A and colleagues, in clarifying the controversy over the past 15 years on the hypoglycemic activity of Aloe species, launched an investigation with separate experiments on three main groups of rats, namely, non-diabetic (ND), type I (IDDM) and type II (NIDDM) diabetic rats.
At the end of the experiment, researchers found that
* Application of Aloe vera A. vera leaf pulp and gel extracts was ineffective in lowering the blood sugar level of ND rats.
* A. vera leaf pulp extract showed hypoglycemic activity on IDDM and NIDDM rats, the effect being enhanced for type II diabetes in comparison with glibenclamide.
* On the contrary, A. vera leaf gel extract showed hyperglycaemic activity in NIDDM rats.
These results suggested, pulps of Aloe vera leaves devoid of the gel could be useful in the treatment of non-insulin-dependent diabetes mellitus.
Taken together Aloe Vera may be considered an adjunct therapy for treatment in patients with non-insulin-dependent type 2 diabetes.
However, due to the limitation of the above studies, additional data collection large example size and multi-center studies performed with human consumption of the whole food Aloe vera during the course of the disease will be necessary to complete the picture of Aloe vera anti-diabetes possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Aloe vera: a systematic review of its clinical effectiveness. by Vogler BK, Ernst E.(PubMed)
(2) Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus. by Kim K, Kim H, Kwon J, Lee S, Kong H, Im SA, Lee YH, Lee YR, Oh ST, Jo TH, Park YI, Lee CK, Kim K.(PubMed)
(3) Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models.
Okyar A, Can A, Akev N, Baktir G, Sütlüpinar N.(PubMed)
(4) Effect of diet on type 2 diabetes mellitus: A review by Waqas Sami,1,2 Tahir Ansari,3 Nadeem Shafique Butt,4 and Mohd Rashid Ab Hamid. (PubMed)
Scientists may have found a natural whole food for the treatment of type II diabetes without inducing any side effects, some studies suggested,
Type II diabetes is a chronic acquired medical condition characterized by insufficient insulin entering the bloodstream to regulate glucose.
The disease is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol.
In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
The exact cause of type II diabetes is unknown. However, some researchers suggested that the condition is most likely caused by genetic mutation and an unhealthy lifestyle.
Other risk factors associated with the early onset of type II diabetes include overweight or obese, age 45 or older, family history, ethnicity, Alaska Native, high blood pressure and cholesterol, and women with polycystic ovary syndrome.
Dr. Waqas Sami, the lead author in the study "Effect of diet on type 2 diabetes mellitus: A review" wrote. "Dietary habits and sedentary lifestyle are the major factors for the rapidly rising incidence of DM among developing countries. In type 2 diabetics, recently, the elevated HbA1c level has also been considered as one of the leading risk factors for developing microvascular and macrovascular complications" and "Improvement in the elevated HbA1c level can be achieved through diet management; thus, the patients could be prevented from developing the diabetes complications. Awareness about diabetes complications and consequent improvement in dietary knowledge, attitude, and practices lead to better control of the disease".
These results suggested changes in diet and lifestyle are the most effective method in the management of type II diabetes.
Medication including Alpha-glucosidase inhibitors. Thiazolidinediones (TZDs) Glucagonlike peptide–1 (GLP-1) agonists. Dipeptidyl peptidase IV (DPP-4) inhibitors used for the treatment of type II diabetes may be effective, however, they are known to induce serious side effects such as low blood sugar, upset stomach, skin rash or itching, and weight gain. kidney complications, upset stomach, tiredness or dizziness,... and metal taste.
If you are currently taking one of the above medicine, please make sure that you discuss the side effects with your doctor and know how to deal with them.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan.
Herbal medicine has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of diseases, including wounds, burn healing, minor skin infections, sebaceous cysts, diabetes, elevated cholesterol, etc.
The Chemical ingredients
The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharides, polysaccharides, salicylic acids, saponins, and sterols.
In the study to examine the clinical effectiveness of aloe vera, a popular herbal remedy in the United Kingdom for the treatment of type II diabetes, researchers at the University of Exeter, launched a review by researching the database of MEDLINE, EMBASE, Biosis, and the Cochrane Library.
Only controlled clinical trials (on any indication) were included in the study.
There were no restrictions on the language of publication. All trials were read and data were extracted in a standardized, pre-defined manner.
After differentiating the 10 selected studies, researchers found that oral administration of aloe vera might be a useful adjunct for lowering blood glucose in diabetic patients as well as for reducing blood lipid levels in patients with hyperlipidemia.
However, the topical application of aloe vera was not an effective preventative for radiation-induced injuries.
Furthermore, Dr. Okyar A and colleagues, in clarifying the controversy over the past 15 years on the hypoglycemic activity of Aloe species, launched an investigation with separate experiments on three main groups of rats, namely, non-diabetic (ND), type I (IDDM) and type II (NIDDM) diabetic rats.
At the end of the experiment, researchers found that
* Application of Aloe vera A. vera leaf pulp and gel extracts was ineffective in lowering the blood sugar level of ND rats.
* A. vera leaf pulp extract showed hypoglycemic activity on IDDM and NIDDM rats, the effect being enhanced for type II diabetes in comparison with glibenclamide.
* On the contrary, A. vera leaf gel extract showed hyperglycaemic activity in NIDDM rats.
These results suggested, pulps of Aloe vera leaves devoid of the gel could be useful in the treatment of non-insulin-dependent diabetes mellitus.
Taken together Aloe Vera may be considered an adjunct therapy for treatment in patients with non-insulin-dependent type 2 diabetes.
However, due to the limitation of the above studies, additional data collection large example size and multi-center studies performed with human consumption of the whole food Aloe vera during the course of the disease will be necessary to complete the picture of Aloe vera anti-diabetes possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Aloe vera: a systematic review of its clinical effectiveness. by Vogler BK, Ernst E.(PubMed)
(2) Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus. by Kim K, Kim H, Kwon J, Lee S, Kong H, Im SA, Lee YH, Lee YR, Oh ST, Jo TH, Park YI, Lee CK, Kim K.(PubMed)
(3) Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models.
Okyar A, Can A, Akev N, Baktir G, Sütlüpinar N.(PubMed)
(4) Effect of diet on type 2 diabetes mellitus: A review by Waqas Sami,1,2 Tahir Ansari,3 Nadeem Shafique Butt,4 and Mohd Rashid Ab Hamid. (PubMed)
#Lentils Inhibit the Risk of Acute and Chronic #InflammatoryDiseases Through Its Antioxidant Activities, Scientists Say
By Kyle J. Norton
Lentils may have a potential effect in inhibiting free radicals expression in reduced risk and treatment of acute and chronic inflammatory diseases, some researchers opinionated.
Lentil is a type of pulse and tiny legume that can be cooked quickly and is rich in protein and fiber is a bushy annual plant of genus Lens to the Fabaceae family, native to the Middle East.
Antioxidants are types of chemical compounds that inhibited the expression of reactive oxygen and nitrogen species to protect the body against oxidative damage.
Reactive oxygen species (ROS) are key signaling molecules played an important role in the generation by polymorphonuclear neutrophils (PMNs) to induce the progression of inflammatory disorders and cytotoxicity in tumor cells. Overexpression of ROS and decreased antioxidant persistence also may cause endothelial dysfunction and tissue injury in the inflammatory sites.
According to the investigation of lentil (Morton) extract protective effect on cardiac hypertrophy, one of the most significant sequelae of cardiovascular diseases suggested that high phenolic compounds (43.4 mg of GAE/g), including thirteen phenolic acid and two flavonoids found in the acetone/water/acetic acid lentil extract, express a significant effect in attenuated Ang II-induced rat in an elevated contraction of blood vessels to cause hypertension and human cardiomyocytes hypertrophy, the loss of contractile mass from prior infarction through activated antioxidant activities in decreased intracellular ROS levels.
ROS elevation and decreased levels of antioxidants have been shown to increase oxidative stress in stimulated lipid peroxidation in the induction of endothelial cell damage and promoted lipid accumulated in the inner wall of arteries, through their effects on inflammation, disturbed blood flow, and arterial wall remodeling.
Lentil's antioxidant properties in the experiment of measurement of injection effects of 2,2-diphenyl-1-picrylhydrazyl (DPPH) in reduced antioxidant power in oxygen radical absorbing capacity, in vitro containing different groups of phenolic compounds also exerted the ability to inhibit the formation of reactive oxygen species, superoxide anion through chelating metal ions or inhibiting ROS -related enzyme expressions.
Furthermore, the analysis of free radical scavenging activities of methanolic extracts of the seed coat and the cotyledon of two varieties of lentils (Lens culinaris L.) and two varieties of dark peas (Pisum sativum L.), suggested that the deed coat of lentils scored a huge antioxidant capacities
compared to the cotyledon in lentils and peas through the significantly higher levels of phenolic compounds with flavonoid structure.
More interestingly, the evaluation of phenolic extracts from 20 Canadian lentil cultivars (Lens culinaris) for total phenolic contents and composition, antioxidant activities (DPPH, FRAP, ORAC), and inhibitory properties against α-glucosidase and pancreatic lipase suggested that phenolic compounds identified including the majority being flavonoids, kaempferol glycosides, catechin/epicatechin glucosides, and procyanidins not only demonstrate significantly antioxidant activities but also express a strong inhibition of α-glucosidase and lipase activities associated with glucose and lipid metabolism in the intestine.
Dr. Florinda Fratiannia, in the study of phenolic contents and antioxidant activities of grass pea (Lathyrus sativus), lentil (Lens culinaris), and chickpea (Cicer arietinum) cultivars from the Campania region of Southern Italy, postulated, "Lentils (cv Colliano and San Gerardo) demonstrated the highest antioxidant activity, (EC50 not higher than 2.3 mg/g), confirming that lentils are an excellent antioxidant food" and " these legumes can be considered therapeutic functional foods due to their significant content of functional proteins and carbohydrates and their extraordinary reserve of secondary metabolites and bioactive constituents that are beneficial for managing and preventing several chronic illnesses in humans".
People who are susceptible or at higher risk of infection may want to add some portions of lentils into
their diet to ameliorate ROS precipitation of inflammation.
The information findings suggested that lentils with huge numbers of phytochemicals may be considered as a functional food in stimulating antioxidant expression through the immune system in fighting against foreign invasion and preventing ROS overproduction in the induction of acute and chronic inflammatory diseases.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Assessment of in vitro antioxidant capacity of the seed coat and the cotyledon of legumes in relation to their phenolic content by M.DueñasT.HernándezI.Estrella(Science direct)
(2) Polyphenol composition and antioxidant activity of different grass pea (Lathyrus sativus), lentils (Lens culinaris), and chickpea (Cicer arietinum) ecotypes of the Campania region (Southern Italy)
Florinda Fratiannia, Federica Cardinalea, Autilia Cozzolinoa, Tiziana Granesea, Donatella Albaneseb, Marisa Di Matteob, Massimo Zaccardellic, Raffaele Coppolaa, Filomena Nazzaroa(Science direct)(3) Phenolic profiles of 20 Canadian lentil cultivars and their contribution to antioxidant activity and inhibitory effects on α-glucosidase and pancreatic lipase by Zhang B1, Deng Z2, Ramdath DD3, Tang Y4, Chen PX5, Liu R3, Liu Q3, Tsao R6.(PubMed)
(4) Review Polyphenol-Rich Lentils and Their Health Promoting Effects Kumar Ganesan ID and Baojun Xu (The International journal of molecular sciences)
(5) Morton lentil extract attenuated angiotensin II-induced cardiomyocyte hypertrophy via inhibition of intracellular reactive oxygen species levels in vitro by Yao FR1, Sun CW, Chang SK.(PubMed)
Lentils may have a potential effect in inhibiting free radicals expression in reduced risk and treatment of acute and chronic inflammatory diseases, some researchers opinionated.
Lentil is a type of pulse and tiny legume that can be cooked quickly and is rich in protein and fiber is a bushy annual plant of genus Lens to the Fabaceae family, native to the Middle East.
Antioxidants are types of chemical compounds that inhibited the expression of reactive oxygen and nitrogen species to protect the body against oxidative damage.
Reactive oxygen species (ROS) are key signaling molecules played an important role in the generation by polymorphonuclear neutrophils (PMNs) to induce the progression of inflammatory disorders and cytotoxicity in tumor cells. Overexpression of ROS and decreased antioxidant persistence also may cause endothelial dysfunction and tissue injury in the inflammatory sites.
According to the investigation of lentil (Morton) extract protective effect on cardiac hypertrophy, one of the most significant sequelae of cardiovascular diseases suggested that high phenolic compounds (43.4 mg of GAE/g), including thirteen phenolic acid and two flavonoids found in the acetone/water/acetic acid lentil extract, express a significant effect in attenuated Ang II-induced rat in an elevated contraction of blood vessels to cause hypertension and human cardiomyocytes hypertrophy, the loss of contractile mass from prior infarction through activated antioxidant activities in decreased intracellular ROS levels.
ROS elevation and decreased levels of antioxidants have been shown to increase oxidative stress in stimulated lipid peroxidation in the induction of endothelial cell damage and promoted lipid accumulated in the inner wall of arteries, through their effects on inflammation, disturbed blood flow, and arterial wall remodeling.
Lentil's antioxidant properties in the experiment of measurement of injection effects of 2,2-diphenyl-1-picrylhydrazyl (DPPH) in reduced antioxidant power in oxygen radical absorbing capacity, in vitro containing different groups of phenolic compounds also exerted the ability to inhibit the formation of reactive oxygen species, superoxide anion through chelating metal ions or inhibiting ROS -related enzyme expressions.
Furthermore, the analysis of free radical scavenging activities of methanolic extracts of the seed coat and the cotyledon of two varieties of lentils (Lens culinaris L.) and two varieties of dark peas (Pisum sativum L.), suggested that the deed coat of lentils scored a huge antioxidant capacities
compared to the cotyledon in lentils and peas through the significantly higher levels of phenolic compounds with flavonoid structure.
More interestingly, the evaluation of phenolic extracts from 20 Canadian lentil cultivars (Lens culinaris) for total phenolic contents and composition, antioxidant activities (DPPH, FRAP, ORAC), and inhibitory properties against α-glucosidase and pancreatic lipase suggested that phenolic compounds identified including the majority being flavonoids, kaempferol glycosides, catechin/epicatechin glucosides, and procyanidins not only demonstrate significantly antioxidant activities but also express a strong inhibition of α-glucosidase and lipase activities associated with glucose and lipid metabolism in the intestine.
Dr. Florinda Fratiannia, in the study of phenolic contents and antioxidant activities of grass pea (Lathyrus sativus), lentil (Lens culinaris), and chickpea (Cicer arietinum) cultivars from the Campania region of Southern Italy, postulated, "Lentils (cv Colliano and San Gerardo) demonstrated the highest antioxidant activity, (EC50 not higher than 2.3 mg/g), confirming that lentils are an excellent antioxidant food" and " these legumes can be considered therapeutic functional foods due to their significant content of functional proteins and carbohydrates and their extraordinary reserve of secondary metabolites and bioactive constituents that are beneficial for managing and preventing several chronic illnesses in humans".
People who are susceptible or at higher risk of infection may want to add some portions of lentils into
their diet to ameliorate ROS precipitation of inflammation.
The information findings suggested that lentils with huge numbers of phytochemicals may be considered as a functional food in stimulating antioxidant expression through the immune system in fighting against foreign invasion and preventing ROS overproduction in the induction of acute and chronic inflammatory diseases.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Assessment of in vitro antioxidant capacity of the seed coat and the cotyledon of legumes in relation to their phenolic content by M.DueñasT.HernándezI.Estrella(Science direct)
(2) Polyphenol composition and antioxidant activity of different grass pea (Lathyrus sativus), lentils (Lens culinaris), and chickpea (Cicer arietinum) ecotypes of the Campania region (Southern Italy)
Florinda Fratiannia, Federica Cardinalea, Autilia Cozzolinoa, Tiziana Granesea, Donatella Albaneseb, Marisa Di Matteob, Massimo Zaccardellic, Raffaele Coppolaa, Filomena Nazzaroa(Science direct)(3) Phenolic profiles of 20 Canadian lentil cultivars and their contribution to antioxidant activity and inhibitory effects on α-glucosidase and pancreatic lipase by Zhang B1, Deng Z2, Ramdath DD3, Tang Y4, Chen PX5, Liu R3, Liu Q3, Tsao R6.(PubMed)
(4) Review Polyphenol-Rich Lentils and Their Health Promoting Effects Kumar Ganesan ID and Baojun Xu (The International journal of molecular sciences)
(5) Morton lentil extract attenuated angiotensin II-induced cardiomyocyte hypertrophy via inhibition of intracellular reactive oxygen species levels in vitro by Yao FR1, Sun CW, Chang SK.(PubMed)
#Phytochemical 3,3'-#Diindolylmethane and #Curcumin Process Anti #ColonCancer Activities, According to Researchers
By Kyle J. Norton
3,3'-Diindolylmethane or DIM may have a profound and positive effect in reducing the risk and treatment of colon cancer, according to studies.
Colon cancer is a chronic condition caused by irregular cell growth in the tissue of the colon.
Most cases of colon cancer start in the cells on the surface of the inner lining of the colon tissue. It is one of most slow-growing cancer that takes years to develop. Therefore, most patients in the early stage of cancer do not experience any symptoms.
However, at the advanced stage, cancer can cause severe rectal bleeding and persistent abdominal pain due to the larger size tumor that has pressed on the nearby nerve cells and blood vessels.
According to the statistics, the risk of CRC increases with age; the median age at diagnosis for colon cancer is 68 in men and 72 in women.
The data of colon provided by CDC showed that every year, 97,000 new cases of colon cancer are diagnosed.
Besides sharing the common symptoms with other types of cancer such as unintended weight loss, loss of appetite, persistent fatigue, and tiredness, patients with colon cancer may also experience symptoms of change of bowel movement, rectal bleeding and persistent abdominal discomforts, such as cramps, gas or pain.
If you experience some of the above symptoms, please make sure you check with your doctor to rule out the possibility.
Although there are many risk factors involved in the onset of colon cancer, some researchers suggested aging may be one of the most prevalent risks.
Donna Myers on the examination of the time that needed for a polyp or growth of tissue in the lining to cancer and the percentage of colon cancer cases in people age 50 or older, said, " By the time colorectal cancer is diagnosed, it has often been growing for several years, first as a non-cancerous polyp and later as cancer. Research indicates that by age 50, one out of four people has polyps".
The results strongly suggested that if you are at the age of 50 and have a higher risk of colon cancer, you may want to have a colonoscopy done every 3 years.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding the natural compounds for the treatment of colon cancer examined the two anti-cancer agents (doxycycline or 3,3'-diindolylmethane) on HCT-116 and HT-29 colon cancer cell lines.
Injection of the 2 compounds resulted in profound changes in the intracellular content of several lncRNAs (by up to 100 times secreted by tumors into the bloodstream.
The results strongly suggested that by examining the levels of lncRNAs colon cancer expression can be monitored through tumor relapse and metastasis.
In order to reveal more information about 3the Sulindac (SU; 320 ppm) effect on colon cancer, researchers examined two natural compounds, 3,3'-diindolylmethane (DIM; 250 ppm) and curcumin (CUR; 2000 ppm), with or without lower doses of SU could affect carcinogenesis.
Colon tumors were significantly reduced by SU 320 ppm (62 % reduction over Controls), by DIM and CUR without or with SU 80 and 160 ppm (50, 53 and 58 % reduction, respectively) but not by SU 80 ppm alone.
Furthermore, total tumors (colon and small intestine) were found to reduce substantially by SU (80 and 320 ppm) and by DIM and CUR.
Apoptosis in the normal mucosa was significantly increased by SU 320 ppm and slightly increased by DIM and CUR with or without SU.
The combination of SU with DIM or Cur also caused a slight reduction in Survivin-Birc5 expression observed with all the treatments compared to controls.
Where Survivin-Birc5 protein is found to inhibit caspases associated with the blocking of cancer cell death. The protein is highly expressed in most cancers associated with poor clinical outcomes.
The results strongly reaffirmed the anti-colon cancer activity of DIM and CUR combination.
Taken altogether, DIM used alone or combined with another bioactive compound may be considered a supplement for the prevention and combined with primary medicine for the treatment of colon cancer, pending the confirmation of a larger sample size and multicenter human study.
Intake of DIM as o form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Treatment with anti-cancer agents results in profound changes in lncRNA expression in colon cancer cells].[Article in Russian] by Zinovieva OL1, Grineva EN1, Prokofjeva MM1, Karpov DS1, Krasnov GS1, Prassolov VS1, Mashkova TD1, Lisitsyn NA. (PubMed)
(2) Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis by Femia AP1, Soares PV2, Luceri C3, Lodovici M4, Giannini A5, Caderni G. (PubMed)
(3) The Link Between Age and Colorectal Cancer Risk by Donna Myers
3,3'-Diindolylmethane or DIM may have a profound and positive effect in reducing the risk and treatment of colon cancer, according to studies.
Colon cancer is a chronic condition caused by irregular cell growth in the tissue of the colon.
Most cases of colon cancer start in the cells on the surface of the inner lining of the colon tissue. It is one of most slow-growing cancer that takes years to develop. Therefore, most patients in the early stage of cancer do not experience any symptoms.
However, at the advanced stage, cancer can cause severe rectal bleeding and persistent abdominal pain due to the larger size tumor that has pressed on the nearby nerve cells and blood vessels.
According to the statistics, the risk of CRC increases with age; the median age at diagnosis for colon cancer is 68 in men and 72 in women.
The data of colon provided by CDC showed that every year, 97,000 new cases of colon cancer are diagnosed.
Besides sharing the common symptoms with other types of cancer such as unintended weight loss, loss of appetite, persistent fatigue, and tiredness, patients with colon cancer may also experience symptoms of change of bowel movement, rectal bleeding and persistent abdominal discomforts, such as cramps, gas or pain.
If you experience some of the above symptoms, please make sure you check with your doctor to rule out the possibility.
Although there are many risk factors involved in the onset of colon cancer, some researchers suggested aging may be one of the most prevalent risks.
Donna Myers on the examination of the time that needed for a polyp or growth of tissue in the lining to cancer and the percentage of colon cancer cases in people age 50 or older, said, " By the time colorectal cancer is diagnosed, it has often been growing for several years, first as a non-cancerous polyp and later as cancer. Research indicates that by age 50, one out of four people has polyps".
The results strongly suggested that if you are at the age of 50 and have a higher risk of colon cancer, you may want to have a colonoscopy done every 3 years.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding the natural compounds for the treatment of colon cancer examined the two anti-cancer agents (doxycycline or 3,3'-diindolylmethane) on HCT-116 and HT-29 colon cancer cell lines.
Injection of the 2 compounds resulted in profound changes in the intracellular content of several lncRNAs (by up to 100 times secreted by tumors into the bloodstream.
The results strongly suggested that by examining the levels of lncRNAs colon cancer expression can be monitored through tumor relapse and metastasis.
In order to reveal more information about 3the Sulindac (SU; 320 ppm) effect on colon cancer, researchers examined two natural compounds, 3,3'-diindolylmethane (DIM; 250 ppm) and curcumin (CUR; 2000 ppm), with or without lower doses of SU could affect carcinogenesis.
Colon tumors were significantly reduced by SU 320 ppm (62 % reduction over Controls), by DIM and CUR without or with SU 80 and 160 ppm (50, 53 and 58 % reduction, respectively) but not by SU 80 ppm alone.
Furthermore, total tumors (colon and small intestine) were found to reduce substantially by SU (80 and 320 ppm) and by DIM and CUR.
Apoptosis in the normal mucosa was significantly increased by SU 320 ppm and slightly increased by DIM and CUR with or without SU.
The combination of SU with DIM or Cur also caused a slight reduction in Survivin-Birc5 expression observed with all the treatments compared to controls.
Where Survivin-Birc5 protein is found to inhibit caspases associated with the blocking of cancer cell death. The protein is highly expressed in most cancers associated with poor clinical outcomes.
The results strongly reaffirmed the anti-colon cancer activity of DIM and CUR combination.
Taken altogether, DIM used alone or combined with another bioactive compound may be considered a supplement for the prevention and combined with primary medicine for the treatment of colon cancer, pending the confirmation of a larger sample size and multicenter human study.
Intake of DIM as o form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Treatment with anti-cancer agents results in profound changes in lncRNA expression in colon cancer cells].[Article in Russian] by Zinovieva OL1, Grineva EN1, Prokofjeva MM1, Karpov DS1, Krasnov GS1, Prassolov VS1, Mashkova TD1, Lisitsyn NA. (PubMed)
(2) Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis by Femia AP1, Soares PV2, Luceri C3, Lodovici M4, Giannini A5, Caderni G. (PubMed)
(3) The Link Between Age and Colorectal Cancer Risk by Donna Myers
#Healthyfood #Broccoli Extracts Inhibit #Hyperglycemia in #Diabetes, According to Studies
By Kyle J. Norton
Type I diabetes is also known as juvenile diabetes or insulin-dependent diabetes associated with not enough or no insulin produced by the pancreas due to the die-off or gradual die-off of the insulin-producing beta cells\
The exact causes of type I diabetes are not identified. However, the condition is a result of the body's own immune system mistakenly that destroys the insulin-producing cells in the pancreas.
Type II diabetes is a chronic acquired medical condition characterized by insufficient insulin entering the bloodstream to regulate glucose.
The disease is either caused by cells in the pancreas die-off or receptor sites clog-up by fat and cholesterol.
In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
The exact cause of type II diabetes is also unknown. However, some researchers suggested that the condition is most likely caused by genetic mutation and an unhealthy lifestyle.
Untreated and unmanageable type I and II diabetes may induce complications of cardiovascular disease, nerve damage (neuropathy), kidney damage (nephropathy), and eye damage (retinopathy). foot damage and skin conditions.
Medication used for the treatment of diabetes is focused on alleviating the symptoms and improving quality of life, particularly, in type II diabetes in slowing down the progression of the disease.
Dr. Waqas Sami, the lead author in the study "Effect of diet on type 2 diabetes mellitus: A review" wrote. "Dietary habits and sedentary lifestyle are the major factors for the rapidly rising incidence of DM among developing countries. In type 2 diabetics, recently, the elevated HbA1c level has also been considered as one of the leading risk factors for developing microvascular and macrovascular complications".
And, "Improvement in the elevated HbA1c level can be achieved through diet management; thus, the patients could be prevented from developing diabetes complications. Awareness about diabetes complications and consequent improvement in dietary knowledge, attitude, and practices lead to better control of the disease".
These results suggested changes in diet and lifestyle are the most effective method in the management of type II diabetes.
Other risk factors associated with the early onset of type II diabetes include overweight or obese, age 45 or older, family history, ethnicity, Alaska Native, high blood pressure and cholesterol, and women with polycystic ovary syndrome
Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower head surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
With an aim to find a potential whole food for the treatment of diabetes, researchers examined the effect of broccoli on type 2 diabetes.
The study included SD rats induced with type 2 diabetes mellitus (T2DM) by a high-fat diet and injecting a low dose (35 mg/kg) of streptozocin were pretreated by treated broccoli extracts at a dose of 200, 400, and 800 mg/kg body weight for 28 days.
According to the tested assays at the 28-day, broccoli extracts showed an improvement in body weight, water, and food intake compared to diabetic control rats.
Compared to the doses viz., 200, 400, and 800 mg/kg body weight demonstrated a significant attenuation in the blood glucose at 180 min in Streptozotocin (STZ) induced diabetic rats, also compared to control.
Based on the findings, researchers wrote in the final report, "The study demonstrated that ethanolic extract of Brassica oleracea extract has potential antidiabetic activities. Thus Brassica oleracea as a vegetable or its extract can be useful to control hyperglycemia".
Taken altogether, broccoli may be considered a functional food for the prevention and treatment of type 2 diabetes, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antidiabetic Potential of Brassica Oleracea Var. Italica in Type 2 Diabetic Sprague Dawley (SD) Rats by Mashood Ahmad Shah, Moklesur Rahman Sarker, and Mohammad GOUSUDDIN Inamdar. (Reseach Gate)
(2) Effect of diet on type 2 diabetes mellitus: A review by Waqas Sami,1,2 Tahir Ansari,3 Nadeem Shafique Butt,4 and Mohd Rashid Ab Hamid. (PubMed)
Type I diabetes is also known as juvenile diabetes or insulin-dependent diabetes associated with not enough or no insulin produced by the pancreas due to the die-off or gradual die-off of the insulin-producing beta cells\
The exact causes of type I diabetes are not identified. However, the condition is a result of the body's own immune system mistakenly that destroys the insulin-producing cells in the pancreas.
Type II diabetes is a chronic acquired medical condition characterized by insufficient insulin entering the bloodstream to regulate glucose.
The disease is either caused by cells in the pancreas die-off or receptor sites clog-up by fat and cholesterol.
In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
The exact cause of type II diabetes is also unknown. However, some researchers suggested that the condition is most likely caused by genetic mutation and an unhealthy lifestyle.
Untreated and unmanageable type I and II diabetes may induce complications of cardiovascular disease, nerve damage (neuropathy), kidney damage (nephropathy), and eye damage (retinopathy). foot damage and skin conditions.
Medication used for the treatment of diabetes is focused on alleviating the symptoms and improving quality of life, particularly, in type II diabetes in slowing down the progression of the disease.
Dr. Waqas Sami, the lead author in the study "Effect of diet on type 2 diabetes mellitus: A review" wrote. "Dietary habits and sedentary lifestyle are the major factors for the rapidly rising incidence of DM among developing countries. In type 2 diabetics, recently, the elevated HbA1c level has also been considered as one of the leading risk factors for developing microvascular and macrovascular complications".
And, "Improvement in the elevated HbA1c level can be achieved through diet management; thus, the patients could be prevented from developing diabetes complications. Awareness about diabetes complications and consequent improvement in dietary knowledge, attitude, and practices lead to better control of the disease".
These results suggested changes in diet and lifestyle are the most effective method in the management of type II diabetes.
Other risk factors associated with the early onset of type II diabetes include overweight or obese, age 45 or older, family history, ethnicity, Alaska Native, high blood pressure and cholesterol, and women with polycystic ovary syndrome
Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower head surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.
With an aim to find a potential whole food for the treatment of diabetes, researchers examined the effect of broccoli on type 2 diabetes.
The study included SD rats induced with type 2 diabetes mellitus (T2DM) by a high-fat diet and injecting a low dose (35 mg/kg) of streptozocin were pretreated by treated broccoli extracts at a dose of 200, 400, and 800 mg/kg body weight for 28 days.
According to the tested assays at the 28-day, broccoli extracts showed an improvement in body weight, water, and food intake compared to diabetic control rats.
Compared to the doses viz., 200, 400, and 800 mg/kg body weight demonstrated a significant attenuation in the blood glucose at 180 min in Streptozotocin (STZ) induced diabetic rats, also compared to control.
Based on the findings, researchers wrote in the final report, "The study demonstrated that ethanolic extract of Brassica oleracea extract has potential antidiabetic activities. Thus Brassica oleracea as a vegetable or its extract can be useful to control hyperglycemia".
Taken altogether, broccoli may be considered a functional food for the prevention and treatment of type 2 diabetes, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antidiabetic Potential of Brassica Oleracea Var. Italica in Type 2 Diabetic Sprague Dawley (SD) Rats by Mashood Ahmad Shah, Moklesur Rahman Sarker, and Mohammad GOUSUDDIN Inamdar. (Reseach Gate)
(2) Effect of diet on type 2 diabetes mellitus: A review by Waqas Sami,1,2 Tahir Ansari,3 Nadeem Shafique Butt,4 and Mohd Rashid Ab Hamid. (PubMed)
#Healthyfood #Chickpeas #Isoflavones #Genistein In Inducing the Death of #ProstateCancer Cells, Studies Show
By Kyle J. Norton
Chickpeas with abundant isoflavones genistein may have a therapeutic and profound effect in reduced risk and treatment of prostate cancer, some scientists suggested.
Garbanzo bean also known as chickpea is an edible legume of genus Cicer and the family Fabaceae, high in protein and minerals. It is one of the earliest cultivated vegetables, native to the Middle East.
Prostate cancer is a medical condition characterized by cells growing uncontrollably in the prostate tissues. At the later stage, the cancerous may infect the tissues and organs distance away from the site of origin.
The investigation of the effects of isoflavone genistein isolated from chickpeas in prostate cancer risk was found to associate with various expressions and mechanisms.
Reactive oxygen species ROS was studied intensively for the duo effects in inhibited cancer development and induced cancer cell apoptosis through cytotoxicity.
On one hand, overexpression of ROS with low antioxidant levels may cause cellular damage and induce alternation of DNA transcript being transmitted by mRNA through a complex passage to initiate irregular cell growth, the early stage of cancer development.
On the other hand, overexpression of ROS can cause cytotoxicity to the target cancer site in the induction of cell death and apoptosis.
Isoflavone genistein isolated from chickpeas was found to exert significant antioxidant effects on human cells, thus ameliorated oxidative damage to cellular DNA in the initiation of cancer development.
Injection of isoflavone genistein to normal cells acted as free radical scavengers not only improved the antioxidants status in inhibited the ROS activity in the inauguration and progression of multistage carcinogenesis but also reduced the expression of oxidative stress-response related genes.
Interestingly, such injection also enhanced the overexpression ROS function in causing toxicity to cancer cells without harming the nearby healthy cells, thus increasing cancer cell degradation, subsequently in cell death.
In fact, isoflavone genistein, best known as natural tyrosine kinase inhibitor (TKIs) are a class of chemo-medicine with function is inhibited, or blocked, the enzyme tyrosine kinase in the induction of apoptosis in several different types of cancers, including prostate cancer.
Further analysis of the effect of isoflavone genistein administration also indicated that the phytochemicals induced cancer cell apoptosis by increased expression of Bax protein in suppressed the production of pro-apoptotic activity in the cancerous site.
Additionally, isoflavone genistein also demonstrated a significant effect in stimulated the p21, a potent cyclin-dependent kinase inhibitor (CKI) expression in promoted cancer cell cycle arrest.
Application of the phytochemicals also decreased anti-apoptotic activities of Bcl-2 and BclXL by blocking the release of mitochondrial contents for enhanced cell division.
More importantly, in the regulation of cellular apoptosis, isoflavone genistein also activated the PARP protein and caspases enzyme with functions to programmed cell death.
Moreover, in further evaluation of cancer cell apoptosis due to injection of isoflavone genistein, researchers at the Second Affiliated Hospital of Xi'an Jiaotong University postulated that in the process in induced cancer cell apoptosis, isoflavone genistein also inhibited NF-κB protein in regulated and controlled transcription of DNA, and cell survival in numbers of cancer, examined by the electrophoresis mobility shift assay (EMSA)
In fact, the expression of NF-κB protein in reduced cancer cell proliferation and site expansion was attributed to the activation of hydrogen peroxide H2O2, with the function of cytotoxicity to the tumor and tumor necrosis factor (TNF-α), a cell-signaling protein with function to initiate cellular apoptosis.
Taken together, isoflavones genistein may be effective in reducing the risk and treatment of prostate cancer depending on some factors involving having or not having equol converting bacteria in the intestine, specific polymorphic variation in the region of the associated gene.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Induction of Cancer Cell Death by Isoflavone: The Role of Multiple Signaling Pathways by Yiwei Li, Dejuan Kong, Bin Bao, Aamir Ahmad, and Fazlul H. Sarkar(PMC)
(1) Chickpea (Cicer arietinum) and other plant-derived protease inhibitor concentrates inhibit breast and prostate cancer cell proliferation in vitro by Magee PJ1, Owusu-Apenten R, McCann MJ, Gill CI, Rowland IR. (PubMed)
(2) Protease inhibitors: possible anticarcinogens in edible seeds by Troll W, Wiesner R.(PubMed)
(4) Isoflavones and Prostate Cancer: A Review of Some Critical Issues by Hong-Yi Zhang,1,2 Jie Cui,3 Ye Zhang,2 Zhen-Long Wang,1 Tie Chong,1 and Zi-Ming Wang1(PMC)
(5) Induction of Cancer Cell Death by Isoflavone: The Role of Multiple Signaling Pathways by Yiwei Li, Dejuan Kong, Bin Bao, Aamir Ahmad, and Fazlul H. Sarkar(PMC)
Chickpeas with abundant isoflavones genistein may have a therapeutic and profound effect in reduced risk and treatment of prostate cancer, some scientists suggested.
Garbanzo bean also known as chickpea is an edible legume of genus Cicer and the family Fabaceae, high in protein and minerals. It is one of the earliest cultivated vegetables, native to the Middle East.
Prostate cancer is a medical condition characterized by cells growing uncontrollably in the prostate tissues. At the later stage, the cancerous may infect the tissues and organs distance away from the site of origin.
The investigation of the effects of isoflavone genistein isolated from chickpeas in prostate cancer risk was found to associate with various expressions and mechanisms.
Reactive oxygen species ROS was studied intensively for the duo effects in inhibited cancer development and induced cancer cell apoptosis through cytotoxicity.
On one hand, overexpression of ROS with low antioxidant levels may cause cellular damage and induce alternation of DNA transcript being transmitted by mRNA through a complex passage to initiate irregular cell growth, the early stage of cancer development.
On the other hand, overexpression of ROS can cause cytotoxicity to the target cancer site in the induction of cell death and apoptosis.
Isoflavone genistein isolated from chickpeas was found to exert significant antioxidant effects on human cells, thus ameliorated oxidative damage to cellular DNA in the initiation of cancer development.
Injection of isoflavone genistein to normal cells acted as free radical scavengers not only improved the antioxidants status in inhibited the ROS activity in the inauguration and progression of multistage carcinogenesis but also reduced the expression of oxidative stress-response related genes.
Interestingly, such injection also enhanced the overexpression ROS function in causing toxicity to cancer cells without harming the nearby healthy cells, thus increasing cancer cell degradation, subsequently in cell death.
In fact, isoflavone genistein, best known as natural tyrosine kinase inhibitor (TKIs) are a class of chemo-medicine with function is inhibited, or blocked, the enzyme tyrosine kinase in the induction of apoptosis in several different types of cancers, including prostate cancer.
Further analysis of the effect of isoflavone genistein administration also indicated that the phytochemicals induced cancer cell apoptosis by increased expression of Bax protein in suppressed the production of pro-apoptotic activity in the cancerous site.
Additionally, isoflavone genistein also demonstrated a significant effect in stimulated the p21, a potent cyclin-dependent kinase inhibitor (CKI) expression in promoted cancer cell cycle arrest.
Application of the phytochemicals also decreased anti-apoptotic activities of Bcl-2 and BclXL by blocking the release of mitochondrial contents for enhanced cell division.
More importantly, in the regulation of cellular apoptosis, isoflavone genistein also activated the PARP protein and caspases enzyme with functions to programmed cell death.
Moreover, in further evaluation of cancer cell apoptosis due to injection of isoflavone genistein, researchers at the Second Affiliated Hospital of Xi'an Jiaotong University postulated that in the process in induced cancer cell apoptosis, isoflavone genistein also inhibited NF-κB protein in regulated and controlled transcription of DNA, and cell survival in numbers of cancer, examined by the electrophoresis mobility shift assay (EMSA)
In fact, the expression of NF-κB protein in reduced cancer cell proliferation and site expansion was attributed to the activation of hydrogen peroxide H2O2, with the function of cytotoxicity to the tumor and tumor necrosis factor (TNF-α), a cell-signaling protein with function to initiate cellular apoptosis.
Taken together, isoflavones genistein may be effective in reducing the risk and treatment of prostate cancer depending on some factors involving having or not having equol converting bacteria in the intestine, specific polymorphic variation in the region of the associated gene.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Induction of Cancer Cell Death by Isoflavone: The Role of Multiple Signaling Pathways by Yiwei Li, Dejuan Kong, Bin Bao, Aamir Ahmad, and Fazlul H. Sarkar(PMC)
(1) Chickpea (Cicer arietinum) and other plant-derived protease inhibitor concentrates inhibit breast and prostate cancer cell proliferation in vitro by Magee PJ1, Owusu-Apenten R, McCann MJ, Gill CI, Rowland IR. (PubMed)
(2) Protease inhibitors: possible anticarcinogens in edible seeds by Troll W, Wiesner R.(PubMed)
(4) Isoflavones and Prostate Cancer: A Review of Some Critical Issues by Hong-Yi Zhang,1,2 Jie Cui,3 Ye Zhang,2 Zhen-Long Wang,1 Tie Chong,1 and Zi-Ming Wang1(PMC)
(5) Induction of Cancer Cell Death by Isoflavone: The Role of Multiple Signaling Pathways by Yiwei Li, Dejuan Kong, Bin Bao, Aamir Ahmad, and Fazlul H. Sarkar(PMC)
#Healthyfood #Cucumber, a Natural #FreeRadicalScavenger, According to Studies
By Kyle J. Norton
Free radical scavengers are antioxidants that inhibit free radicals before they can induce a chain of domino reactions that has been found to cause protein, lipid, and cell damage, leading to cell injury and cell death.
Most common free radical scavengers can be either produced by the host or from dietary sources, including catalases, glutathione peroxidase, superoxide dismutase (SOD), and vitamins A, C, and E.
Oxidative stress is imbalanced with the ratio of antioxidants and free radicals. In other words, overexpression of free radicals and low levels of antioxidants in the body can lead to oxidative stress, a major cause of chronic diseases such as cardiovascular disease, diabetes, and cancer.
In a healthy individual, dietary, antioxidant, and antioxidant enzymes produced by the liver are more than enough to counter free radicals produced from all sources.
However, for people with a weakened immune system, intake of antioxidant supplements may be necessary, and in chronic illness patients, antioxidant supplementation at an early stage of illness has been found to improve therapies.
Due to the complexity of treating chronic and critical illness patients, some researchers suggested that
professionals need to understand the mechanism of damage caused by free radicals and free radical scavenger's protective activity for the treatment of varied pathological conditions.
The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural compound that processes anti-free radical overexpression, researchers investigated the aqueous fruit extract of Cucumis sativus L. anti-free radical scavenging activities.
In vitro, aqueous fruit extract at 250 and 500 μg/ml showed a significant effect on the inhibition of free radicals through scavenging activity.
Compared to other chemical compounds, The C. sativus fruit extract showed maximum antioxidant and at 500 μg/ml and 500 mg/kg,
The efficacy of the extracts was attributed to the presence of flavonoids and tannins evidenced by preliminary phytochemical screening.
Additionally, in the comparison of carrot, cucumber, and broccoli seed flours extracted with 50% acetone for their free radical scavenging property researcher found that
* Cucumber showed a strong free radical scavenging property against DPPH radical scavenging capacity, oxygen radical absorbing capacity, and hydroxyl radical (HO•) scavenging capacity secondary to the broccoli seed flour extract.
* in ABTS•+ scavenging capacity of 250 μmol TE/g, carrot showed a better effect compared to cucumber.
Based on the findings, Dr. Choe U, the lead scientist wrote in the final report, "The results might be used to promote the value-added utilization of these vegetable seed flours in improving human health".
Taken altogether, cucumber may be used for the treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Free Radical Scavenging and Analgesic Activities of Cucumis sativus L. Fruit Extract by Kumar D1, Kumar S, Singh J, Narender, Rashmi, Vashistha B, Singh N. (PubMed)
(2) Chemical Compositions of Cold-Pressed Broccoli, Carrot, and Cucumber Seed Flours and Their in Vitro Gut Microbiota Modulatory, Anti-inflammatory, and Free Radical Scavenging Properties by Choe U1, Li Y1,2, Gao B2, Yu L1, Wang TTY, Sun J, Chen P, Liu J3, Yu L. (PubMed)
(3) Free radical scavengers in anaesthesiology and critical care by Milind S Hatwalne. (PMC)
Free radical scavengers are antioxidants that inhibit free radicals before they can induce a chain of domino reactions that has been found to cause protein, lipid, and cell damage, leading to cell injury and cell death.
Most common free radical scavengers can be either produced by the host or from dietary sources, including catalases, glutathione peroxidase, superoxide dismutase (SOD), and vitamins A, C, and E.
Oxidative stress is imbalanced with the ratio of antioxidants and free radicals. In other words, overexpression of free radicals and low levels of antioxidants in the body can lead to oxidative stress, a major cause of chronic diseases such as cardiovascular disease, diabetes, and cancer.
In a healthy individual, dietary, antioxidant, and antioxidant enzymes produced by the liver are more than enough to counter free radicals produced from all sources.
However, for people with a weakened immune system, intake of antioxidant supplements may be necessary, and in chronic illness patients, antioxidant supplementation at an early stage of illness has been found to improve therapies.
Due to the complexity of treating chronic and critical illness patients, some researchers suggested that
professionals need to understand the mechanism of damage caused by free radicals and free radical scavenger's protective activity for the treatment of varied pathological conditions.
The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural compound that processes anti-free radical overexpression, researchers investigated the aqueous fruit extract of Cucumis sativus L. anti-free radical scavenging activities.
In vitro, aqueous fruit extract at 250 and 500 μg/ml showed a significant effect on the inhibition of free radicals through scavenging activity.
Compared to other chemical compounds, The C. sativus fruit extract showed maximum antioxidant and at 500 μg/ml and 500 mg/kg,
The efficacy of the extracts was attributed to the presence of flavonoids and tannins evidenced by preliminary phytochemical screening.
Additionally, in the comparison of carrot, cucumber, and broccoli seed flours extracted with 50% acetone for their free radical scavenging property researcher found that
* Cucumber showed a strong free radical scavenging property against DPPH radical scavenging capacity, oxygen radical absorbing capacity, and hydroxyl radical (HO•) scavenging capacity secondary to the broccoli seed flour extract.
* in ABTS•+ scavenging capacity of 250 μmol TE/g, carrot showed a better effect compared to cucumber.
Based on the findings, Dr. Choe U, the lead scientist wrote in the final report, "The results might be used to promote the value-added utilization of these vegetable seed flours in improving human health".
Taken altogether, cucumber may be used for the treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Free Radical Scavenging and Analgesic Activities of Cucumis sativus L. Fruit Extract by Kumar D1, Kumar S, Singh J, Narender, Rashmi, Vashistha B, Singh N. (PubMed)
(2) Chemical Compositions of Cold-Pressed Broccoli, Carrot, and Cucumber Seed Flours and Their in Vitro Gut Microbiota Modulatory, Anti-inflammatory, and Free Radical Scavenging Properties by Choe U1, Li Y1,2, Gao B2, Yu L1, Wang TTY, Sun J, Chen P, Liu J3, Yu L. (PubMed)
(3) Free radical scavengers in anaesthesiology and critical care by Milind S Hatwalne. (PMC)
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