#Healthyfood #Cranberry Modifies All Parameters Associated with the Onset of Cancers, Studies Show

By Kyle J. Norton

Cancer is a class of diseases characterized by abnormal cell growth that begins in the cells on the surface of the inner lining of the tissue of an organ caused by the alternation of cell DNA with unknown nature.

Under normal circumstances, cell growth is a natural process that happens daily to replace millions of dead cells. In some cases, acceleration of cell growth is necessary to prevent further damage to the body organ, such as cut, injury, etc., but after fulfilling their purposes, the growth of cells is back to a normal rate again through regulated growth inhibitors.

In other words, healthy cell division is limited to a number of cycles. Comapred to normal cells, cells with an alternation of DNA or cancer cells can grow indefinitely.

Unfortunately, skin cells sometimes overgrow while healing, leading to scars on the skin.

At an early, most people with cancer are asymptomatic, however, later, due to the size and the tumor, patients may experience general cancer symptoms such as unintended weight loss, fatigue, gastrointestinal discomfort, and loss of appetite, and localized symptoms such as severe pain and bleeding.


Cancer can be classified by the types of cells that have become malignant.
* Carcinoma
Carcinoma is a malignant tumor found in anywhere of epithelial tissues lining the cavities, surfaces of structures and glands.

* Sarcoma
Sarcoma is a type of cancer that arises from malignantly connective tissue cells that originated from embryonic germ cells or bone, cartilage, and fat tissues and cells.

* Lymphoma and leukemia
Hematopoietic cells are multipotent stem cells that give rise to all types of blood cells, including red blood cells, white blood cells, and platelets that become cancerous.

* Germ cell tumor
Cancer derived from pluripotent cells. In adults, these are most often found in the testicle and ovary but are more common in babies and young children.

* Blastoma
Blastoma is cancer derived from immature "precursor" or embryonic tissue, mostly in children.

The causes of cancer are not identified. However, most prevalent factors associated with the cancer onset include age, family history, long-term exposure to certain cancer-induced chemicals, use of tobacco, and excessive alcohol drinking,..... the list goes on and on, depending on the type of cancer.

Some researchers suggested that the most common risk factor that causes cancer in the Western world may be associated with widespread obesity.

Dr. Karen Basen-Engquist, in the evaluation of obesity risk of cancer, said, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%".And, "High priorities for future research involve additional work on the underlying mechanisms, and trials to examine the effect of lifestyle behavior change and weight loss interventions on cancer and intermediate biomarkers".

The findings strongly indicated the risk of cancer is increased substantially in obese.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

In finding a potential compound for the treatment of invasive tumors, researchers examined the potential effects of cranberry on cancer prevention and treatment.

According to the review of the medical literature by searching the database of PubMed, cranberry and/or its components may act as chemopreventive agents, that diminish the parameters associated with the onset of cancer, including the inhibition of cells oxidation and inflammatory-related processes, in vitro.

Cell proliferation and angiogenesis and metastasis involved in cancer cell invasion were also attenuated by the administration of cranberry's apoptotic activity.

Dr. Mantzorou M, the lead scientist, after taking other factors into account wrote, " Cranberry could be considered as a conglomeration of potential effective anticancer drug-like compounds".

Additionally, in chemical constituents analysis, cranberry showed inhibitory action against cancers of the esophagus, stomach, colon, bladder, prostate, glioblastoma and lymphoma.


The efficacy of anticancer activity was attributed to the chemical compounds that work synergistically to result in cellular death induction via apoptosis, necrosis, and autophagy, reduction of cellular proliferation, the elevation of reactive oxygen species, and modification of cytokine and signal transduction pathways, similar to those of aforementioned study.

Taken altogether, cranberry may be considered a remedy for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cranberries and Cancer: An Update of Preclinical Studies Evaluating the CancerInhibitory Potential of Cranberry and Cranberry Derived Constituents by Weh KM1, Clarke J2,3,4, Kresty LA. (PubMed)
(2)Cranberry as a Promising Natural Source of Potential Nutraceuticals with Anticancer Activity by Mantzorou M1, Zarros A2, Theocharis S3, Pavlidou E1, Giaginis C. (PubMed)
(3) Obesity and Cancer Risk: Recent Review and Evidence by Karen

#Phytochemical 3,3'-Diindolylmethane Processes #AntiMalignantMesothelioma Activities, Scientists Show

By Kyle J. Norton

The bioactive compound 3,3'-Diindolylmethane or DIM may process strong and positive effects against the risk and progression of mesothelioma, according to studies.
Mesothelioma is a medical condition characterized by irregular cell growth in the thin layer of tissue that covers the internal organs, due to cell DNA alternation.

However, according to epidemiological studies, the most common area affected is the lining of the lungs and chest wall.

Most cases of mesothelioma start in the cell on the surface of the layered tissue. At the later stage, the cells of the larger size of tumor can cause secondary tumors to develop in nearby organs and distant locations through the circulation of blood and fluids, leading to secondary metastasis.

The most common symptoms of mesothelioma are persistent dry cough or wheezing, shortness of breath, pain in the chest or abdomen, fatigue, and weakness.

In severe cases, patients may also experience symptoms of respiratory complications such as pleural effusion (fluid around the lungs).

If you experience some of the above symptoms, please check with your doctor to rule out the possibility.

The most common causes of mesothelioma are due to long-term exposure to asbestos as the disease is found in 80% of the patients. However, suggested that genetic preposition may also be the prevalent risk factor of the disease.


Dr. Ombretta Melaiu, the lead scientist in the investigation of the genetic susceptibility in the development of malignant pleural mesothelioma (MPM), wrote, "Among asbestos-exposed workers, several studies reported familial cases of MPM, suggesting that heredity could be important in the tumor development,.... the risk of developing MPM is increased of a limited extent among people exposed to asbestos with a positive history of familial cancers".

And, "In families and in animal models, mutations within BAP1 are strongly predisposing to develop MPM".

The results clearly suggested that if you carry the mutation gene BAP1, you are at a higher risk of MPM and other types of cancer.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.

Scientists concerned about malignant mesothelioma (MM), a very aggressive, lethal cancer, and its incidence is increasing worldwide examined the dietary phytochemicals which may process the potential for the treatment of MM with no side effect.

The study included several bioactive ingredients such as curcumin, epigallocatechin gallate, quercetin, genistein, pterostilbene, resveratrol, capsaicin, ellagic acid, benzyl isothiocyanate, phenethyl isothiocyanate, sulforaphane, indole-3-carbinol, 3,3'-diindolylmethane (DIM), diallyl disulfide, betulinic acid, and oleanolic acid.

DIM was found to process the anti-MM activity by boosting the function of microRNA in the regulation of the activities of the genes.


Where MicroRNAs (miRNAs) are a class of small noncoding RNAs of ∼22nt in length involved in the regulation of gene expression against the incidence of cancer. Increased expression of microRNAs is associated with numerous types of cancer.

Overexpression of miR-132 in vivo was associated with the severity of cancer patients.

Injection of DIM exerted anti mesothelioma potentials, through the expression of microRNA regulatory activities.was attributed to the suppression of macrophage infiltration and pro-inflammatory cytokines.

In other words, DIM modulated the immune response against the onset and progression of mesothelioma caused by the production of oxidative stress due to the overexpression of inflammatory cytokines in the initiation of the disease.

Dr. Sayeed MA the lead scientist wrote in the final report, "In addition to microRNA regulatory activities, curcumin, epigallocatechin gallate, quercetin, genistein, resveratrol, phenethyl isothiocyanate, and sulforaphane have anti-mesothelioma potentials, and pterostilbene, capsaicin, ellagic acid, benzyl isothiocyanate, indole-3-carbinol, 3,3'-diindolylmethane, diallyl disulfide, betulinic acid, and oleanolic acid have potentials to inhibit cancer by regulating the expression of various genes which are also known to be aberrant in MM".

Taken altogether, DIM may be considered a supplement for the prevention and combined with primary therapy for the treatment of MM, pending the confirmation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Regulation of microRNA using promising dietary phytochemicals: Possible preventive and treatment option of malignant mesothelioma by Sayeed MA1, Bracci M2, Lucarini G2, Lazzarini R2, Di Primio R2, Santarelli L. (PubMed)
(2) The genetic susceptibility in the development of malignant pleural mesothelioma by Ombretta Melaiu, Federica Gemignani, and Stefano Landi. (PMC)

#Antioxidant #Alliin Found in Garlics and Onions Suppresses the Onset of Hypercholesterolemia in Vivos, Researchers Say

By Kyle J. Norton

Hypercholesterolemia is a chronic condition associated with abnormally high blood cholesterol in the blood
In other words, hypercholesterolemia is a result of overexpression of low-density lipoprotein compared to low levels of high-density lipoprotein.

Low-density cholesterol also known as bad cholesterol produced by the liver or dietary saturated and trans fat in moderate amounts plays a critical role in building a strong cell wall, production of steroid hormones and vitamin D, and aiding the gastrointestinal tract in the absorption of nutrients.

However, high levels of bad cholesterol have been found to induce hypercholesterolemia, a leading cause of heart disease and stroke.

High-density lipoprotein or good cholesterol, on the other hand, returns the amount of excess cholesterol back to the liver for future use.

High-density lipoprotein is also produced by the liver and dietary sources found mostly in nuts and fish.
The healthy ratio of LDL/HDL is any number less than 4.

Although there are many risk factors that cause the onset of hypercholesterolemia, some researchers suggested the introduction of a high-fat diet in North America over the past few decades may accelerate the rise of the condition.

Dr. Cole TG, the lead scientist, in a randomized controlled parallel-designed intervention study to evaluate the effects of a diet with less than 20 g carbohydrates per day (LCHF) on plasma low-density lipoprotein cholesterol (LDL-C) in young and healthy adults wrote, "There was a significant increase in apolipoprotein B, total cholesterol, high-density lipoprotein cholesterol, free fatty acids, uric acid and urea in the LCHF group versus controls".

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

In finding a natural compound for the treatment of hypercholesterolemia, researchers investigated
the effect of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) on the serum cholesterol, and triglyceride in rats fed with a high cholesterol diet.

Rats selected for the study were randomly dived into experimental rats fed with a 2% high cholesterol diet with and without garlic powder for 6 weeks and control rats fed with a normal diet daily.

High cholesterol-fed animals had a significant increase in serum cholesterol compared to the control group of rats fed on a normal diet.

However, in the rat group fed with a high-cholesterol diet mixed with garlic powder, researchers found that there was a significant reduction in their serum cholesterol levels compared to other groups.

Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) also lowered the serum triglyceride levels compared to control and high cholesterol diet group rats without affecting the serum glucose and protein.

The finding clearly suggested that Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) is beneficial in reducing blood cholesterol, and triglycerides levels in hypercholesterolemic rats.
In order to reveal more information about alliin anti-high blood cholesterol activity, researchers evaluated the capacity of Allium ursinum (wild garlic) leaf lyophilisate (WGLL; alliin content: 0.261%) to mitigate cardiovascular damage in hypercholesterolemic rabbits.

The selected New Zealand rabbits were divided into three groups: (i) cholesterol-free rabbit chow (control); (ii) rabbit chow containing 2% cholesterol (hypercholesterolemic, HC); (iii) rabbit chow containing 2% cholesterol + 2% WGLL (hypercholesterolemic treated, HCT); for eight weeks.

During the study, the WGLLtreated group showed a decrease in aortic atherosclerotic plaque coverage, plasma ApoB, a protein in atherogenic lipoprotein particles associated with heart disease associated with reduced blood cholesterol.

Furthermore, the activity of LDH and CK (creatine kinase) in plasma is also found to be lower compared to other treatment groups.

The plasma LDL was also significantly reduced in the WGLL-treated group.

Taken altogether, alliin may be considered supplements for the prevention and treatment of hypercholesterolemia, pending the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-Atherogenic Properties of Allium ursinum Liophylisate: Impact on Lipoprotein Homeostasis and Cardiac Biomarkers in Hypercholesterolemic Rabbits by Bombicz M1,2, Priksz D3,4, Varga B5,6, Gesztelyi R7, Kertesz A8, Lengyel P9, Balogh P10, Csupor D11, Hohmann J12, Bhattoa HP13, Haines DD14, Juhasz B. (PubMed)
(2) Effect of garlic on lipid profile and psychopathologic parameters in people with mild to moderate hypercholesterolemia by Peleg A1, Hershcovici T, Lipa R, Anbar R, Redler M, Beigel Y. (PubMed)
(3) Effect of low carbohydrate high fat diet on LDL cholesterol and gene expression in normal-weight, young adults: A randomized controlled study by Retterstøl K1, Svendsen M2, Narverud I3, Holven KB. (PubMed)

#Antioxidant #Isothiocyanates in the Inhibition of #Cancer Initiation, According to Studies

By Kyle J. Norton

Dithiolthione, a phytochemical found abundantly in cruciferous vegetables may be the next target for the development of chemo medicine for the treatment of cancer without inducing any side effects, some studies suggested.
Cancers are a class of chronic and medical conditions characterized by cell growth disorderly and uncontrollably that starts on the inner lining of the tissue of an organ due to the alternation of cell DNA.

At the advanced stage, most cancer cells can travel a distance away from the original site to infect other healthy tissue and organs through blood and fluid circulation.

The causes of cancer are unknown. Epidemiological studies suggested that depending on the type of cancer, the most common risk factors are aging, tobacco, sun exposure, radiation exposure, chemicals toxins, viruses and bacteria, change of hormones, family history, excessive alcohol drinking, poor diet, lack of physical activity and overweight or obesity.

However, most people with some of the above risk factors have never developed cancer.

A genetic preposition and acquired genetic mutation are the most risk factors that can precisely predict the percentage of prevalent risk of the onset of the disease.

Mutation of gene TP53 and PTEN. which produces a protein that suppresses the growth of tumors, genetic mutation of BRCA1 and BRCA2 genes is associated with a higher risk of cancer.

In acquiring genetic mutation, some researchers suggested that the result of errors in the cell cycle division caused by long-term exposure to carcinogenic substances such as tobacco smoke and occupations which are required chemical exposure that also damages the cell's DNA are also some prevalent factors associated with the increased risk of cancers.

The US National Library of Medine wrote "For example, certain mutations in the BRCA1 or BRCA2 genes greatly increase a person's risk of developing breast cancer and ovarian cancer. Variations in other genes, such as BARD1 and BRIP1, also increase breast cancer risk, but the contribution of these genetic changes to a person's overall risk appears to be much smaller".


Furthermore, on the other front of acquired genetic mutation, Dr. Michael R. Stratton, the lead author in the study "The cancer genome" said, "The cancer cell may have acquired, from exogenous sources, completely new DNA sequences, notably those of viruses such as human papillomavirus, Epstein Barr virus, hepatitis B virus, human T lymphotropic virus 1 and human herpesvirus 8, each of which is known to contribute to the genesis of one or more type of cancer".

Some researchers proposed that cancer may be a result of weakened immunity, Dr. Louise M.E. Janssen, the lead scientist in the study "The immune system in cancer metastasis: friend or foe?" said, "The primary tumor induces an immune response, which may not be sufficient to destroy the primary tumor, but prevents the growth of a secondary tumor or metastases. Since that time, many different immune cells have been shown to play a role in both inhibiting and promoting metastatic disease".

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

In the concerns of chemo drug side effects in the treatment of invasive cancers, researchers in the cancer team at the Shanghai Jiaotong University School of Medicine conducted an experiment to test the association between urinary levels of isothiocyanates (ITCs) and the risk of pancreatic cancer in urban Shanghai.

The case-control study has been conducted in urban Shanghai from December 2006 to December 2008) through a newly established "instant case reporting" system.

Intake of cruciferous vegetable intake and ITC consumption, urinary ITC levels (median (P25, P75)) was 95.0 (66.9, 135.8) g/d, 11.0 (7.1, 16.0) µmol/d, 0.95 (0.12, 2.92) µmol/g Cr respectively in treatment cases, all lower than those of controls, separately 107.4 (80.1, 154.1) g/d, 12.3 (8.0, 18.0) µmol/d, 1.78 (0.53, 5.28) µmol/g Cr with statistically significant differences of 3.75.

The urinary levels of ITCs in all cases were found to have a correlation with cruciferous vegetable consumption and dietary ITC exposure.

Further analysis suggested that there is an inverse association between urinary ITCs and the risk of pancreatic cancer after adjusting for possible confounding factors such as age, sex, history of diabetes, and pancreatitis.

Dr. the lead author said, " High levels of cruciferous vegetables or ITC consumption were associated with a reduced risk of pancreatic cancer (all P trend <0.05)".

Moreover, in the study to test the combination of Thiazolo and isothiocyanates antiproliferative activity in a panel of 8 cancer cell lines, including lung (NCI-H322 and A549), epidermal (A431), glioblastoma (T98G), pancreatic (MIAPaCa-2), prostate (PC-3), human leukemia (HL-60) and breast (T47D) cells, researchers found that

* The application compound showed the induction of apoptosis in A549 cells at 10 μM, as indicated by the increase in the sub-G1 population.

* The compounds also induced apoptosis in HL-60 cells at 20 μM. The effect of compound 4a on mitochondrial potential loss in HL-60 cells. was also studied.ct

These results suggested that Thiazolo under the influence of isothiocyanates demonstrated potency in the inhibition of all cancer cell lines in a concentration and dose-dependent manner without inducing any side effects.

More importantly, Dr.de Figueiredo SM, the lead scientist at the Campus Morro do Cruzeiro in the study "The anti-oxidant properties of isothiocyanates: a review" revealed that ITCs induce Phase II enzymes related to detoxification processes of chemical carcinogens to prevent the start of carcinogenesis and exhibit antitumor activity at post-initiation phase.

Additionally, the lead researcher also suggested that ITCs inhibit the cell viability of human cervical cancer cells, human pancreatic cancer cells, human hepatocellular carcinoma cells, and human ovarian cancer cells, and have anti-inflammatory properties in the treatment of human T-cell leukemia cells probably through improving antioxidant status.

Taken altogether, Phytochemical Isothiocyanates found abundantly in cruciferous vegetables may be considered a bioactive functional ingredient for the prevention and treatment of cancers, depending on the large sample size and multi-center in the human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) [A case-control study on the association between urinary levels of isothiocyanates and the risk of pancreatic cancer].[Article in Chinese] by Wang J1, Han L, Zhang W, Wang J, Ni Q, Shen M, Gao Y2.(PubMed)
(2) Synthesis, antiproliferative and apoptosis-inducing activity of thiazolo[5,4-d]pyrimidines by Singh B1, Guru SK, Kour S, Jain SK, Sharma R, Sharma PR, Singh SK, Bhushan S, Bharate SB, Vishwakarma RA.(PubMed)
(3) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB.(PubMed)
(4) The immune system in cancer metastasis: friend or foe? by Janssen LME1, Ramsay EE2, Logsdon CD2, Overwijk WW. (PubMed)

#Cucurbitacins (CuB) Processes Antioxidant and ted withCytotoxic Activity Against Diseases Caused by Oxidativestress, Researchers Say

By Kyle J. Norton

Antioxidants are atoms that inhibit oxidation.
Cytotoxicity is an action that kills cancer cells by inducing toxins in the cells.

Antioxidant activity is an action in which the stable atoms inhibit the expression of free radicals including antioxidants with free radical scavenging properties.

In other words, an antioxidant produced by the host or from a dietary source balances the levels of free radicals produced by cellular metabolism and from outside of our body.

In a healthy individual, antioxidant enzymes produced by the body are good enough to counter the expression of free radicals. However, in people with a weakened immune system such as the elderly, the intake of antioxidant supplements may be necessary.

Free radicals are unstable atoms with a single electron in the outer ring. Therefore, in order to remain stable. free radicals are ready to donate or intercept an electron from other atoms, leading to a chain of oxidative reactions that can not be stopped until all electrons are paired or inhibited by antioxidants.

Oxidative stress is an imbalanced ratio of free radicals and antioxidants in the body. It is caused by either overexpression of free radicals or depletion of antioxidants in the body.

Believe it or not. overexpression of free radicals for a long period of time or oxidative stress can cause cell and lipid damage, leading to the alteration of cell DNA.

Diseases associated with oxidative stress include atherosclerosis, cancer, diabetes, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation,... and stroke.

The risk of oxidative stress can be reduced by lifestyle change and moderate exercise.

Dr. Tameko Kihira, the lead scientist in the correlation of lifestyle and oxidative stress in patients with amyotrophic lateral sclerosis (ALS) wrote, "Recent lifestyle changes among the K residents, including a decrease in the Japanese pickle consumption, increase in fresh vegetable consumption and decrease in farm work, were evaluated in this study. Low consumption of Japanese pickles, high consumption of fresh vegetables, rare farm work, and low levels of 8-OHdG/creatinine were all associated with high scores in the cognitive function tests. Frequent farm work and consumption of Japanese pickles were associated with high contents of transition metals, such as Mn, Al, and V, in the scalp hair".

The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

On finding a natural and potential ingredient for the treatment of diseases associated with oxidative stress, researchers investigated the effect of Cucurbitacins (CuB), a major bioactive compound found in cucumber.

According to the antioxidative analysis, Cucurbitacins (CuB), not only showed significant scavenging free-radicals activity such as hydroxyl radical, superoxide anions, and singlet oxygen but also inhibited lipid peroxidation and oxidation.

In other words, CuB protected cells' integrity by inhibiting the free radical expression before they can induce a chain of reaction to cause oxidative stress to the tissues and organs.

Furthermore, Cub also processes anti-inflammatory and analgesic properties by modulating the immune response against the production of proinflammatory cytokines in facilitating cellular and lipid damage and DNA alternation.
In the growth of four NSCLC cells (H1299, A549, HCC-827, and H661) Cucurbitacin B (CuB) inhibited cancer cell proliferation by altering the actin cytoskeletal assembly in the cell by cell cycle arrest and mitochondrial apoptosis.

Cucurbitacin B (CuB) inhibited the antioxidant activity produced by the cancer cells by significantly decreasing levels of protein thiols and GSH/GSSG ratio.

In other words, CuB causes cancer cell apoptosis by inducing cytotoxicity by disrupting the cancer cellular redox balance.

The results strongly suggested that on the one hand, CuB killed cancer cells through its cytotoxic by inducing overexpression of free radicals, and on the other hand CuB protected the healthy cells against cytotoxic damage through its antioxidant property.

Taken altogether, cucumber-processed abundantly bioactive compound CuB may be used for the treatment of diseases associated with oxidative stress and cancer, pending the confirmation of the larger sample size and multicenter human study.


Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Search for a novel antioxidant, anti- inflammatory/analgesic or anti-proliferative drug: Cucurbitacins hold the ace by Adebowale Bernard Saba, and Olayinka Oridupa. (Research Gate)
(2) Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets by Kausar H1, Munagala R, Bansal SS, Aqil F, Vadhanam MV, Gupta RC. (PubMed)
(3) Lifestyle Changes and Oxidative Stress in a High-incidence Area of Amyotrophic Lateral Sclerosis in the Southwestern Kii Peninsula, Japan by Tameko Kihira,1 Kazushi Okamoto,2 Iori Sakurai,1 Yuya Arakawa,1 Ikuro Wakayama,1Koichi Takamiya,3 Ryo Okumura,3 Yuhto Iinuma,3 Keiko Iwai,4 Yasumasa Kokubo,5 andSohei Yoshida. (PMC)

#Healthyfood #RedCabbages Protect the Skin Against Contact #Dermatitis by Inhibiting the Expression of Pro-Inflammatory Cytokines

By Kyle J. Norton

Contact dermatitis is a skin condition with symptoms of a red, itchy rash caused by direct contact with a substance or an immune overreaction against contact allergens.

The skin is the largest organ of the body containing 3 layers including the epidermis, the dermis, and the hypodermis. The skin also is the third detoxed organ combined with the liver and kidney to cleanse the body's toxins.

Many chemicals and nonchemical substances have been found to induce such abnormal reactions, including cosmetics, fragrances, jewelry, and plants.

Most cases of contact dermatitis are nonlife-threatening, however, the condition can induce certain discomforts, particularly in people with an allergic reaction and medical conditions.

The skin condition caused by an allergic reaction can be healed within a week or 2. Contact dermatitis can be preventable if the cause is identified.

Most common symptoms of contact dermatitis red, itchy rash on the skin. Some people may also experience more serious symptoms including crusting swelling, burning, or tenderness skin.

Some researchers suggested contact dermatitis may be associated with the inflammatory skin condition caused by the production of pro-inflammatory and toxic factors that activated the skin's innate immunity, such as irritant contact dermatitis and allergic contact dermatitis.


Dr. Freudenberg MA, the lead scientist at the Max-Planck-Institute for Immunobiology, wrote, "Although DC and effector T cells play a protagonistic role in the sensitization and elicitation phase of ACD, respectively, other cell types including keratinocytes, NK cells, mast cells, and B cells contribute to the pathogenesis of the disease"

And, ": In this review, the authors summarize recent findings that identify stress responses and innate immune pathways triggered by contact allergens and review recent data regarding the adaptive T cell response".

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem that is crowded with a mass of leaves, usually green but in some varieties, it may be red or purplish.

With an aim to find a potential compound for the promotion of skin health, researchers investigated the anti-inflammatory effects of methanol extract of B. oleracea var. capitata L. (MEBO) in mice with contact dermatitis (CD) including ear swelling, erythema, and histopathological changes.
According to the results obtained from the tested analysis, topical treatment with MEBO showed significant inhibition of ear swelling and erythema.

Furthermore, MEBO also significantly inhibited epidermal hyperplasia associated with the overdevelopment of a number of cells in the epidermis and immune cell infiltration in the induction of inflammation.

Compared to the control, the levels of pro-inflammatory cytokines such as tumor necrosis factor-alpha, interferon-gamma, interleukin-6, and monocyte chemotactic protein-1 in MEBO-treated mice were significantly lower also compared to those in controls.

However, there is no body weight gain or spleen body weight ratio in the treatment group.

Based on the findings, researchers said, "These results indicate that cabbage can be used for the treatment of skin inflammation and that its anti-inflammatory activity is closely related to the inhibition of Th1 skewing reactions (associated with pathogenicity or protection from disease)".

Taken altogether, red cabbage may be considered a functional food for the treatment of contact dermatitis, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Influences of Orally Taken Carotenoid-Rich Curly Kale Extract on Collagen I/Elastin Index of the Skin by Meinke MC1, Nowbary CK2, Schanzer S3, Vollert H4, Lademann J5, Darvin ME. (PubMed)
(1) Innate and adaptive immune responses in contact dermatitis: analogy with infections by Freudenberg MA1, Esser PR, Jakob T, Galanos C, Martin SF. (PubMed)

#Healthyfood #CucumberLeaves and It's #Cucurbitacins (CuB) Exerts Neuro-Protective Activities Through Mediated Neuronal Injury

By Kyle J. Norton

The neuroprotective effect is the process that preserves the neuronal structure and/or function, In other words, it is the action that protects the integrity and viability of the neurons against pathogens associated with the loss and death of neurons in the brain.
Neurodegenerative diseases are a class of diseases that involve the loss of neurons over time, leading to multiple neurological disorders including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and ALS, affecting mostly in older adults over the age of 50.

According to the statistics provided by the Harvard Neurodicover Center, as of today, 5 million Americans are living with Alzheimer's disease; 1 million from Parkinson's; 400,000 from multiple sclerosis (MS); 30,000 from amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), and 30,000 from Huntington's disease.

Believe it or not, by 2030, 1 in 5 people living in the US are over the age of 65.

Neurological disorders are a class of diseases associated with reduced function of the brain, particularly in the autonomic nervous systems.

There is no single cause of the neurological disorder. Certain risk factors such as unhealthy lifestyle with physical inactivity, infections, genetic preposition, and physical injury have been found in patients with the condition.

The most common symptoms of the neurological disorder include muscle weakness, loss of sensation reduced reading and writing skills, poor cognitive abilities, and decreased alertness, depending on the location of the neurons that have been affected

In severe cases, patients with a neurological disorder may experience symptoms of depression and anxiety and partial or complete paralysis.


Out of many aforementioned factors associated with neurological disorders, some researchers suggested the increase in age may be one of the major risks that affect millions of older Americans.

Dr. Khan ZU, the lead scientist wrote, "Memory is central to our ability to perform daily life activities and correctly function in society. Improvements in public health and medical treatment for a variety of diseases have resulted in longer life spans; however, age-related memory impairments have been significant sources of morbidity".

And, "Loss in memory function is not only associated with the aging population but is also a feature of neurodegenerative diseases such as Alzheimer's disease and other psychiatric and neurological disorders".

The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

In the urgency to find a potential compound with neuroprotective activity, researchers in the science team at the Benha University compared the protective effect of Cucumis melo var. flexuosus (C. Melo var. flexuosus) leaf extract on the brains of diabetic rats.

The study included adult male albino rats divided into 5 groups of 6 rats each assigned to a normal control group and four diabetic groups with diabetes induced by a single intraperitoneal injection of streptozotocin (STZ; 60 mg/kg bw).

On diabetic rats, one group was left untreated and was considered a diabetic control group while the three other groups were treated with C. Melo var. flexuosus leaf extract at the doses of 30, 60, and 120 mg/kg bw for a period of 30 days.

Based on the results of the tested assays, the C. Melo var. flexuosus leaf extract group not only showed a significant effect on lowering blood glucose, and glycated hemoglobin but also protect the neuron against the facilitation of brain tumor necrosis factor-alpha and production of proinflammatory cytokines.

Furthermore, the brain malondialdehyde content associated with the stress marker and caspase-3 activity associated with neuroapoptosis were also reduced significantly by the injection of C. Melo var. flexuosus leaf extract.

Additional differentiation of the effect of C. Melo var. flexuosus leaf extract group, researchers found that the leaf extract protected the brain cells by markedly increasing the levels of plasma dopamine, melatonin, brain vascular endothelial growth factor-A associated with the formation of blood vessels., Brain antioxidants.

In other words, cucumber leaf extract exerted neuroprotective activity by enhancing the levels of antioxidants against oxidative damage in tested diabetics.

In order to reveal more information about cucumber brain-protective effects, researchers examined the anti-neuroinflammatory effects of Cucurbitacins (CuB) on TLR 2/4 agonists (amyloid-β, LTA, and LPS)-induced neuroinflammatory response in microglia.

According to the tested results, in TLR 2/4 agonists-stimulated microglia, pretreatment with Cucurbitacins significantly reduced the pro-inflammatory cytokine (TNF-α, IL-1β, and IL-6) and enzymes involved in angiogenesis and neural development (iNOS) in affected neurons and stimulation of inflammation (COX-2).

Furthermore, Cucurbitacins protected brain cell damage by inhibiting the protein associated with the stress response in the induction of neurons apoptosis and autophagy and in the facilitation of cytokine production.

In other words, Cucurbitacins protected the integrity of the neurons against TLR 2/4 agonists-stimulated microglia involved in oxidative stress-induced cell death and phase II detoxification enzymes activity.

Based on the findings, Dr.Park SY, the lead scientist said, "Cucurbitacins is a potent activator of the Nrf2/ARE pathway and is therapeutically relevant not only to neuroinflammatory responses of microglia but also neuroinflammation mediated neuronal injury".

Taken altogether, cucumber leaf extracts and the bioactive compound Cucurbitacins may process a neuroprotective effect, pending the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources

(1) Neuroprotective effect of Cucumis melo Var. flexuosus leaf extract on the brains of rats with streptozotocin-induced diabetes by Ibrahim DS. (PubMed)
(2) Cucurbitacins attenuate microglial activation and protect from neuroinflammatory injury through Nrf2/ARE activation and STAT/NF-κB inhibition by Park SY1, Kim YH1, Park G2. (PubMed)
(3) Memory deficits in aging and neurological diseases by Khan ZU1, Martín-Montañez E2, Navarro-Lobato I1, Muly EC. (PubMed)