By Kyle J. Norton
Alfalfa is found to express neuroprotective effects against acute and progressive neurodegenerative disorders.
Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, cultivated all over the world as hay for cattle feeding, and used in traditional medicine over thousands of years to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance digestive system, bleeding disorder, kidney and urinary tract infection, etc. North American aboriginal has used Alfalfa seed as food, such as making bread and mush.
Neuroprotection is the action to preserve the neuronal structure and/or function of the brain, particularly in the delay of neurodegenerative diseases and enhanced integrity of neurons.
According to the L.R. Institute of Pharmacy, methanol extract of Medicago sativa (MS) induced neuroprotective effect through antioxidant and anti-inflammatory activities against ischemia and reperfusion-induced cerebral injury in mice as free radicals expression is elevated with deletion of antioxidants, such as glutathione (GSH), superoxide dismutase (SOD) and total tissue sulfhydryl (T-SH) groups.
Indeed, mice treated with Medicago sativa (MS) exhibited significantly scavenged free radicals activity against a stable radical 1,1-diphenyl-2-picrylhydrazyl and O(•-) (2) and also inhibited XD/XO conversion and resultant O(•-) (2) production.
Dr. Bora KS, the lead researcher said, "Treatment with MS enhances the antioxidant defense against BCAO-induced global cerebral ischemia and exhibits neuroprotective activity".
Furthermore, in the review of 117 references compiled from major databases such as Chemical Abstracts, Science Direct, SciFinder, PubMed, Dr. Dukes Phytochemical and Ethnobotany, CIMER, and InteliHealth, M. sativa seems to hold great potential for various biological activities, including heart disease and neuroprotective effects, attributed to some major classes of phytoconstituents, including
saponins, flavonoids, phytoestrogens, coumarins, alkaloids, amino acids, phytosterols, vitamins, digestive enzymes, and terpenes.
With all the available scientific literature indicated above, alfalfa may attract the attention of natural product researchers to focus on the unexplored therapeutic potential of M. sativa, particularly in the neuroprotective area.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) Evaluation of Antioxidant and Cerebroprotective Effect of Medicago sativa Linn. against Ischemia and Reperfusion Insult by Bora KS1, Sharma A.(PubMed)
(2) Phytochemical and pharmacological potential of Medicago sativa: a review by Bora KS1, Sharma A.(PubMed)
Wednesday, 7 June 2023
#Betanin, Isolated from Beetroot Protects the Skin Against the Onset of #Cancer, Scientists Say
By Kyle J. Norton
Skin cancer is a chronic medical condition caused by cell growth irregularly in the inner layer of the skin.
Skin is the largest organ in our body that covers the bone, inner organs, and tissues with the function to protect our body against the invasion of foreign pathogens.
Skin also plays an essential role to eliminate the toxins from our body, if the liver and kidney fail to do so.
Believe it or not, skin cancer accounts for more than half of the cancers diagnosed every year in the US.
As of today, 58 million Americans are living with skin cancer and one in five Americans will develop skin cancer by the age of 70.
Skin cancer is caused by a number of factors. People with fair skin, a history of sunburns, excessive sun exposure, moles, precancerous skin lesions, and a family and personal history of skin cancer are found to an increased risk of the disease.
Some researchers suggested regardless of ethnicity and skin tone, people who live in sunny or high-altitude climates are more likely to develop skin cancer compared to people who do not.
Dr. Abrar A. Qureshi, wrote, " The risk of SCC is independently affected by residence in locations with medium and high UV indices, the gradient of risk is weaker for BCC, and the risk of melanoma does not change significantly across this gradient.
And, "Geographic location and UV radiation have been implicated as risk-modifying factors for melanoma, squamous cell carcinoma (SCC), basal cell carcinoma,...".
Betanin is a Phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In finding a potential compound for the treatment of skin cancer, researchers evaluated betanin, a major compound isolated from beetroot's skin protective effect.
The study included mouse skin tumor promotion with 3430 J/m(2) of ultraviolet light-B (UV-B) was pretreated by oral administration of 0.0025% betanin.
Betanin showed a significant protective effect in the inhibition of skin damage caused by exposure to ultraviolet light-B (UV-B).
Furthermore, at the same dose, betanin also afforded significant protection in the mouse skin cancer model caused by topical application of 390 nmol of (+/-)-(E)-4-methyl-2-[(E)-hydroxyamino]-5-nitro-6-methoxy-3-hexanamide (NOR-1) in 100 micro of acetone and 1.7 nmol of 12-O-tetradecanoylphorbol-13-acetate (TPA).
Based on the findings, suggest that betanin at a very low dose may be considered a regularly consumed natural product colorant and an effective cancer chemopreventive agent in vivo.
Taken altogether, betanin may be considered a supplement for the prevention and treatment of skin cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot by Kapadia GJ1, Azuine MA, Sridhar R, Okuda Y, Tsuruta A, Ichiishi E, Mukainake T, Takasaki M, Konoshima T, Nishino H, Tokuda H. (PubMed)
(2) Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract by Kapadia GJ1, Tokuda H, Konoshima T, Nishino H. (PubMed)
(3) Geographic Variation and Risk of Skin Cancer in US WomenDifferences Between Melanoma, Squamous Cell Carcinoma, and Basal Cell Carcinoma by Abrar A. Qureshi, MD, MPH; Francine Laden, ScD; Graham A. Colditz, MD, DrPH. (JAMA Network)
Skin cancer is a chronic medical condition caused by cell growth irregularly in the inner layer of the skin.
Skin is the largest organ in our body that covers the bone, inner organs, and tissues with the function to protect our body against the invasion of foreign pathogens.
Skin also plays an essential role to eliminate the toxins from our body, if the liver and kidney fail to do so.
Believe it or not, skin cancer accounts for more than half of the cancers diagnosed every year in the US.
As of today, 58 million Americans are living with skin cancer and one in five Americans will develop skin cancer by the age of 70.
Skin cancer is caused by a number of factors. People with fair skin, a history of sunburns, excessive sun exposure, moles, precancerous skin lesions, and a family and personal history of skin cancer are found to an increased risk of the disease.
Some researchers suggested regardless of ethnicity and skin tone, people who live in sunny or high-altitude climates are more likely to develop skin cancer compared to people who do not.
Dr. Abrar A. Qureshi, wrote, " The risk of SCC is independently affected by residence in locations with medium and high UV indices, the gradient of risk is weaker for BCC, and the risk of melanoma does not change significantly across this gradient.
And, "Geographic location and UV radiation have been implicated as risk-modifying factors for melanoma, squamous cell carcinoma (SCC), basal cell carcinoma,...".
Betanin is a Phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In finding a potential compound for the treatment of skin cancer, researchers evaluated betanin, a major compound isolated from beetroot's skin protective effect.
The study included mouse skin tumor promotion with 3430 J/m(2) of ultraviolet light-B (UV-B) was pretreated by oral administration of 0.0025% betanin.
Betanin showed a significant protective effect in the inhibition of skin damage caused by exposure to ultraviolet light-B (UV-B).
Furthermore, at the same dose, betanin also afforded significant protection in the mouse skin cancer model caused by topical application of 390 nmol of (+/-)-(E)-4-methyl-2-[(E)-hydroxyamino]-5-nitro-6-methoxy-3-hexanamide (NOR-1) in 100 micro of acetone and 1.7 nmol of 12-O-tetradecanoylphorbol-13-acetate (TPA).
Based on the findings, suggest that betanin at a very low dose may be considered a regularly consumed natural product colorant and an effective cancer chemopreventive agent in vivo.
Taken altogether, betanin may be considered a supplement for the prevention and treatment of skin cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot by Kapadia GJ1, Azuine MA, Sridhar R, Okuda Y, Tsuruta A, Ichiishi E, Mukainake T, Takasaki M, Konoshima T, Nishino H, Tokuda H. (PubMed)
(2) Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract by Kapadia GJ1, Tokuda H, Konoshima T, Nishino H. (PubMed)
(3) Geographic Variation and Risk of Skin Cancer in US WomenDifferences Between Melanoma, Squamous Cell Carcinoma, and Basal Cell Carcinoma by Abrar A. Qureshi, MD, MPH; Francine Laden, ScD; Graham A. Colditz, MD, DrPH. (JAMA Network)
#Healthyfood #CucumberSeed Processes Anti-Hyperlipidemic Properties In Vivo and Clinical Trial
By Kyle J. Norton
Hyperlipidemia is a medical condition associated with abnormally high levels of lipids, including cholesterol and fat in the bloodstream.
People with hyperlipidemia are symptomatic. However, depending on the amount of lipid accumulated on the arterial wall, some people in the advanced stage may be at substantial risk to heart disease and stroke.
Hyperlipidemia is a condition of the cluster of metabolic syndrome. If untreated, it can lead to atherosclerosis, a condition of hardening and narrowing of the arteries that facilitates the onset of coronary artery disease.
According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.
Conventionally, hyperlipidemia is treatable. Most patients with the condition are treated by prescribed high-cholesterol medicine statins, such as simvastatin, lovastatin, atorvastatin, and rosuvastatin.
However, for people with a high risk of cardiovascular diseases, PCSK9 inhibitors, such as Redpath (evolocumab) may be prescribed.
If you are taking medicine to lower your blood cholesterol, please make sure that you know all the side effects of preventive measures.
Although there are many factors that cause the onset of hyperlipidemia, some researchers suggested the promotion of a high-fat diet over the past few decades may have strong implications in inducing the rise of hyperlipidemia in the US.
Dr. Cole TG,, the lead scientist wrote, " In normals, dietary cholesterol increases LDL production and decreases LDL receptor-related LDL clearance, resulting in elevations in LDL cholesterol levels of approximately 30 mg/dL".
And, " the effects of high fat and high cholesterol diets on the lipoproteins of individuals with diminished LDL receptors, three kinds of diets, including ones high in cholesterol, were fed to four patients with familial hypercholesterolemia, in the expectation that diet effects on apoB- or apoE-containing lipoproteins would be exaggerated".
The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
In a concern of hyperlipidemia associated with increased risk of atherosclerosis, researchers examined the Cucumber (Cucumis sativus) seed effect on how to control this risk factor for the prevention of atherosclerosis.
The randomized double-blind placebo-controlled clinical trial included hyperlipidemic patients randomly assigned to either Cucumis (n=23) used one medicinal capsule or placebo groups (n=24)used one placebo capsule once daily with food for 6 wks.
According to the tested assays, at the end of the experiment, Cucumis seed extract showed a significant reduction of total cholesterol, triglycerides (TG), low-density lipoprotein (LDL-C), and body mass index (BMI) and a significant increase of high-density lipoprotein (HDL-C), compared to the placebo group.
More precisely, the consumption of C. sativus seed extract with a daily dose of 500 mg exerted a maximum effect on the serum lipid profile in adult hyperlipidemic patients.
In other words, cucumber (Cucumis sativus) seed not only reduces the expression of hyperlipidemia but also inhibited the risk of atherosclerosis.
Furthermore, in vivo, researchers in the CVD team at the Sharadchandra Pawar College of Pharmacy evaluated the anti-hyperlipidemic activity of Cucumis melo fruit peel (CMFP) methanolic and aqueous extract in high cholesterol diet-induced hyperlipidemic rats.
Injection of CMFP methanolic and aqueous extract resulted in a significant (P<0.01) reduction in gaining body weight, serum lipid profile like total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) level.
Compared to the hyperlipidemic control group, the treatment group showed a strong effect on the atherogenic index and an increase of the serum high-density lipoprotein cholesterol (HDL-C) levels in 28 days.
Treatment groups also exerted anti-hyperlipidemic activity observed by the increased fecal excretion of bile acids and sterols similar to that of standard drugs.
Once again, the administration of a methanolic extract of CMFP at a dose of 500 mg/kg showed higher antihyperlipidemic activity, compared to other extract doses.
Taken altogether, cucumber may be used for the treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of the Effects of Cucumis sativus Seed Extracts on Serum Lipids in Adult Hyperlipidemic Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial by Soltani R1, Hashemi M2, Farazmand A1, Asghari G3, Heshmat-Ghahdarijani K2, Kharazmkia A4, Ghanadian SM. (PubMed)
(2) The anti-hyperlipidemic activity of Cucumis melo fruit peel extracts in high cholesterol diet induced hyperlipidemia in rats by Bidkar JS1, Ghanwat DD, Bhujbal MD, Dama GY. (PubMed)
(3) Effects of high cholesterol high fat diet on plasma lipoproteins in familial hypercholesterolemia by Cole TG, Pfleger B, Hitchins O, Schonfeld G. (PubMed)
Hyperlipidemia is a medical condition associated with abnormally high levels of lipids, including cholesterol and fat in the bloodstream.
People with hyperlipidemia are symptomatic. However, depending on the amount of lipid accumulated on the arterial wall, some people in the advanced stage may be at substantial risk to heart disease and stroke.
Hyperlipidemia is a condition of the cluster of metabolic syndrome. If untreated, it can lead to atherosclerosis, a condition of hardening and narrowing of the arteries that facilitates the onset of coronary artery disease.
According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL.
Conventionally, hyperlipidemia is treatable. Most patients with the condition are treated by prescribed high-cholesterol medicine statins, such as simvastatin, lovastatin, atorvastatin, and rosuvastatin.
However, for people with a high risk of cardiovascular diseases, PCSK9 inhibitors, such as Redpath (evolocumab) may be prescribed.
If you are taking medicine to lower your blood cholesterol, please make sure that you know all the side effects of preventive measures.
Although there are many factors that cause the onset of hyperlipidemia, some researchers suggested the promotion of a high-fat diet over the past few decades may have strong implications in inducing the rise of hyperlipidemia in the US.
Dr. Cole TG,, the lead scientist wrote, " In normals, dietary cholesterol increases LDL production and decreases LDL receptor-related LDL clearance, resulting in elevations in LDL cholesterol levels of approximately 30 mg/dL".
And, " the effects of high fat and high cholesterol diets on the lipoproteins of individuals with diminished LDL receptors, three kinds of diets, including ones high in cholesterol, were fed to four patients with familial hypercholesterolemia, in the expectation that diet effects on apoB- or apoE-containing lipoproteins would be exaggerated".
The cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
In a concern of hyperlipidemia associated with increased risk of atherosclerosis, researchers examined the Cucumber (Cucumis sativus) seed effect on how to control this risk factor for the prevention of atherosclerosis.
The randomized double-blind placebo-controlled clinical trial included hyperlipidemic patients randomly assigned to either Cucumis (n=23) used one medicinal capsule or placebo groups (n=24)used one placebo capsule once daily with food for 6 wks.
According to the tested assays, at the end of the experiment, Cucumis seed extract showed a significant reduction of total cholesterol, triglycerides (TG), low-density lipoprotein (LDL-C), and body mass index (BMI) and a significant increase of high-density lipoprotein (HDL-C), compared to the placebo group.
More precisely, the consumption of C. sativus seed extract with a daily dose of 500 mg exerted a maximum effect on the serum lipid profile in adult hyperlipidemic patients.
In other words, cucumber (Cucumis sativus) seed not only reduces the expression of hyperlipidemia but also inhibited the risk of atherosclerosis.
Furthermore, in vivo, researchers in the CVD team at the Sharadchandra Pawar College of Pharmacy evaluated the anti-hyperlipidemic activity of Cucumis melo fruit peel (CMFP) methanolic and aqueous extract in high cholesterol diet-induced hyperlipidemic rats.
Injection of CMFP methanolic and aqueous extract resulted in a significant (P<0.01) reduction in gaining body weight, serum lipid profile like total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) level.
Compared to the hyperlipidemic control group, the treatment group showed a strong effect on the atherogenic index and an increase of the serum high-density lipoprotein cholesterol (HDL-C) levels in 28 days.
Treatment groups also exerted anti-hyperlipidemic activity observed by the increased fecal excretion of bile acids and sterols similar to that of standard drugs.
Once again, the administration of a methanolic extract of CMFP at a dose of 500 mg/kg showed higher antihyperlipidemic activity, compared to other extract doses.
Taken altogether, cucumber may be used for the treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Evaluation of the Effects of Cucumis sativus Seed Extracts on Serum Lipids in Adult Hyperlipidemic Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial by Soltani R1, Hashemi M2, Farazmand A1, Asghari G3, Heshmat-Ghahdarijani K2, Kharazmkia A4, Ghanadian SM. (PubMed)
(2) The anti-hyperlipidemic activity of Cucumis melo fruit peel extracts in high cholesterol diet induced hyperlipidemia in rats by Bidkar JS1, Ghanwat DD, Bhujbal MD, Dama GY. (PubMed)
(3) Effects of high cholesterol high fat diet on plasma lipoproteins in familial hypercholesterolemia by Cole TG, Pfleger B, Hitchins O, Schonfeld G. (PubMed)
#Phytochemical 3,3'-Diindolylmethane Inhibits #ColorectalCancer Through Some Unknown Mechanisms, Researchers Find
By Kyle J. Norton
3,3'-Diindolylmethane or DIM may be used as a bioactive compound for the treatment of colorectal cancer with no side effects, according to studies.
Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells' DNA.
According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.
The lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
Approximately, 140,000 cases of colorectal cancer were diagnosed in the US in 2018. Cancer also causes the death of over 50, 000 people, representing 8.3% of total cancer death.
Being overweight or obese. smoking, physical inactivity, excessive alcohol drinking, increased in age, family and personal history, and genetic preposition are some of the prevalent risks of the disease.
Some researchers suggested that an unhealthy diet such as the promotion of the Western diet over the past few decades may be one of the major causes of colorectal cancer.
Dr. Alan Moss, the lead scientist in the evaluation of the association between diet and colorectal cancer risk, wrote, "Studies that examined dietary factors and various cancers showed that one of the strongest associations is between CRC and meat consumption"
And "Recently, global publicity was generated by the World Health Organization International Agency for Research on Cancer consensus statement regarding the increased risk of CRC with consumption of processed or red meat.4 The 2015 statement notes that processed meat is carcinogenic to humans and lists processed meat as a group 1 substance. Processed meats result from salting, smoking, fermenting, or curing the meat, and common examples include ham, bacon, and sausage".
The results clearly suggested that by changing your diet pattern from the Western diet to a traditional diet with high fruits and vegetables, your risk of colorectal can be reduced substantially.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.
Researchers concerned about the slow growth of colorectal cancer and the prognosis in colorectal cancer patients examined the effects of 3,3'-Diindolylmethane (DIM) on cyclin D1, which was aberrantly overexpressed in colorectal cancer cells and tumors.
Where cyclin D1 is a protein needed for cellular proliferation in the G1 phase of the cell cycle.
Injection of DIM inhibited the cyclin D1 expression in colorectal cancer cells (CRC), without affecting the PPARĪ³ expression and protease activity in regulating the process of cell differentiation.
Moreover, DIM inhibition of the cell cycle in the G1 phase of colorectal cancer cells (CRC) without alternating the cyclin D1 mRNA expression. The results suggested DIM modulated cyclin D1 expression at the translational level through some unknown mechanisms.
Dr. Zhang X and colleagues wrote in the final report, "The present study demonstrates that DIM downregulates cyclin D1 through triggering ER stress in human colorectal cancer cells".
In other words, DIM-induced cell cycle arrest of the colorectal cancer cells by modulating the G1 phase of the cell cycle.
Additionally, in order to reveal more information about the DIM anti-colorectal cancer activity, researchers elucidated the molecular mechanism of ATF3 induction by DIM in human CRC cells.
The DIM treatment induced apoptosis and induced ATF3 gene expression at protein and messenger RNA levels, involving the DNA repair of the damaged cells.
However, in colorectal cancer cells, deletion and point mutation of the ATF binding site (-23 to -16) abolished ATF3 promoter activation by DIM, leading to overexpression of ATF4 associated with the promotion of metabolic homeostasis and cancer cell survival
In other words, DIM stimulates ATF3 expression inducing apoptosis in human colorectal cells by inhibiting the ATF4-mediated pathway.
Taken altogether, 3,3'-Diindolylmethane derived from I3C may be considered a supplement for the prevention and combined with primary therapy for the treatment of colorectal cancer, pending the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells by Zhang X1, Sukamporn P2, Zhang S3, Min KW4, Baek SJ. (PubMed)
(2) 3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells by Lee SH1, Min KW, Zhang X, Baek SJ. (PubMed)
(3) The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations
Alan Moss, and Kumanan Nalankilli. (Gastroenterology)
3,3'-Diindolylmethane or DIM may be used as a bioactive compound for the treatment of colorectal cancer with no side effects, according to studies.
Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells' DNA.
According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.
The lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
Approximately, 140,000 cases of colorectal cancer were diagnosed in the US in 2018. Cancer also causes the death of over 50, 000 people, representing 8.3% of total cancer death.
Being overweight or obese. smoking, physical inactivity, excessive alcohol drinking, increased in age, family and personal history, and genetic preposition are some of the prevalent risks of the disease.
Some researchers suggested that an unhealthy diet such as the promotion of the Western diet over the past few decades may be one of the major causes of colorectal cancer.
Dr. Alan Moss, the lead scientist in the evaluation of the association between diet and colorectal cancer risk, wrote, "Studies that examined dietary factors and various cancers showed that one of the strongest associations is between CRC and meat consumption"
And "Recently, global publicity was generated by the World Health Organization International Agency for Research on Cancer consensus statement regarding the increased risk of CRC with consumption of processed or red meat.4 The 2015 statement notes that processed meat is carcinogenic to humans and lists processed meat as a group 1 substance. Processed meats result from salting, smoking, fermenting, or curing the meat, and common examples include ham, bacon, and sausage".
The results clearly suggested that by changing your diet pattern from the Western diet to a traditional diet with high fruits and vegetables, your risk of colorectal can be reduced substantially.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.
Researchers concerned about the slow growth of colorectal cancer and the prognosis in colorectal cancer patients examined the effects of 3,3'-Diindolylmethane (DIM) on cyclin D1, which was aberrantly overexpressed in colorectal cancer cells and tumors.
Where cyclin D1 is a protein needed for cellular proliferation in the G1 phase of the cell cycle.
Injection of DIM inhibited the cyclin D1 expression in colorectal cancer cells (CRC), without affecting the PPARĪ³ expression and protease activity in regulating the process of cell differentiation.
Moreover, DIM inhibition of the cell cycle in the G1 phase of colorectal cancer cells (CRC) without alternating the cyclin D1 mRNA expression. The results suggested DIM modulated cyclin D1 expression at the translational level through some unknown mechanisms.
Dr. Zhang X and colleagues wrote in the final report, "The present study demonstrates that DIM downregulates cyclin D1 through triggering ER stress in human colorectal cancer cells".
In other words, DIM-induced cell cycle arrest of the colorectal cancer cells by modulating the G1 phase of the cell cycle.
Additionally, in order to reveal more information about the DIM anti-colorectal cancer activity, researchers elucidated the molecular mechanism of ATF3 induction by DIM in human CRC cells.
The DIM treatment induced apoptosis and induced ATF3 gene expression at protein and messenger RNA levels, involving the DNA repair of the damaged cells.
However, in colorectal cancer cells, deletion and point mutation of the ATF binding site (-23 to -16) abolished ATF3 promoter activation by DIM, leading to overexpression of ATF4 associated with the promotion of metabolic homeostasis and cancer cell survival
In other words, DIM stimulates ATF3 expression inducing apoptosis in human colorectal cells by inhibiting the ATF4-mediated pathway.
Taken altogether, 3,3'-Diindolylmethane derived from I3C may be considered a supplement for the prevention and combined with primary therapy for the treatment of colorectal cancer, pending the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells by Zhang X1, Sukamporn P2, Zhang S3, Min KW4, Baek SJ. (PubMed)
(2) 3,3'-diindolylmethane induces activating transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells by Lee SH1, Min KW, Zhang X, Baek SJ. (PubMed)
(3) The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations
Alan Moss, and Kumanan Nalankilli. (Gastroenterology)
#Herbal #Ashwagandha Promotes Healthy Neuron Activity and Brain Function by Inhibiting the OverExpression of Oxidativestress
By Kyle J. Norton
The brain formed part of the central nervous system is the most complex organ made up of more than billions of nerve cells or neurons.
The functions of the brain are associated with the communication of trillions of connections called synapses and many specialized regions.
A neuron or nerve cell made of a cell body (also called soma), dendrites and an axon, is a cell in the nervous system that carries electrical impulses.
Neurons are core components of the brain, spinal cord and peripheral nerves that play an essential role to process and transmit information.
The function of neurons can be classified into 3 types
* The sensory neurons found within the nervous system that convert external stimuli from the organism's environment into internal electrical impulses. In other words, sensory neurons are activated by sensory input from the environment, including physical input of sound, touch, heat, or light.
* The motor neurons transmit information from the spinal cord to skeletal and smooth muscles,. In other words, motor neurons directly control all of the muscle movements.
* The interneurons connect the motor and sensory neurons. In other words, the interneurons transfer signals between sensory and motor neurons.
Believe it or not, there are more than 600 diseases of the central nervous system, including brain tumors, epilepsy, dementia such as Parkinson's disease and Alzheimer's disease, and stroke.
The top 3 neurological diseases include
* Alzheimer's disease (AD) is a neurodegenerative disease in the elderly, associated with the worsening of memory, thinking, and behavior that severe enough to affect language communication, memory, lifelong hobbies, or social life
* Bell's Palsy is a condition caused by sudden weakness or paralysis of facial muscles on one side of the face.
* Cerebral Palsy is a neurological disorder of children affecting a child's movement, motor skills, and muscle tone.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of brain health, researchers examined the effects of Ashwagandha (WA) extracts (alcoholic and water) and their bioactive components for neuroprotective activities against oxidative stress in cultured glioblastoma and neuroblastoma cells.
According to the tested analysis, the extracts and one of the purified components at a low dose protected the glial and neuronal cells from oxidation, an important activity that promotes neuron activity.
Furthermore, glutamate insult induced by oxidative stress was also inhibited by the application of Ashwagandha (WA) extracts (alcoholic and water) and their bioactive components.
Based on the findings, researchers said, "the combinations of extracts and active component were highly potent endorsing the therapeutic merit of the combinational approach".
And, "Ashwagandha leaf-derived bioactive compounds have neuroprotective potential and may serve as a supplement for brain health.s".
Taken altogether, Ashwagandha may be considered a functional herb for the promotion of brain functioning, pending the result of a larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combinations of Ashwagandha leaf extracts protect brain-derived cells against oxidative stress and induce differentiation by Shah N1, Singh R1, Sarangi U1, Saxena N1, Chaudhary A1, Kaur G2, Kaul SC1, Wadhwa R. (PubMed)
(2) Protective role of Ashwagandha leaf extract and its component withanone on scopolamine-induced changes in the brain and brain-derived cells by Konar A1, Shah N, Singh R, Saxena N, Kaul SC, Wadhwa R, Thakur MK. (PubMed)
The brain formed part of the central nervous system is the most complex organ made up of more than billions of nerve cells or neurons.
The functions of the brain are associated with the communication of trillions of connections called synapses and many specialized regions.
A neuron or nerve cell made of a cell body (also called soma), dendrites and an axon, is a cell in the nervous system that carries electrical impulses.
Neurons are core components of the brain, spinal cord and peripheral nerves that play an essential role to process and transmit information.
The function of neurons can be classified into 3 types
* The sensory neurons found within the nervous system that convert external stimuli from the organism's environment into internal electrical impulses. In other words, sensory neurons are activated by sensory input from the environment, including physical input of sound, touch, heat, or light.
* The motor neurons transmit information from the spinal cord to skeletal and smooth muscles,. In other words, motor neurons directly control all of the muscle movements.
* The interneurons connect the motor and sensory neurons. In other words, the interneurons transfer signals between sensory and motor neurons.
Believe it or not, there are more than 600 diseases of the central nervous system, including brain tumors, epilepsy, dementia such as Parkinson's disease and Alzheimer's disease, and stroke.
The top 3 neurological diseases include
* Alzheimer's disease (AD) is a neurodegenerative disease in the elderly, associated with the worsening of memory, thinking, and behavior that severe enough to affect language communication, memory, lifelong hobbies, or social life
* Bell's Palsy is a condition caused by sudden weakness or paralysis of facial muscles on one side of the face.
* Cerebral Palsy is a neurological disorder of children affecting a child's movement, motor skills, and muscle tone.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of brain health, researchers examined the effects of Ashwagandha (WA) extracts (alcoholic and water) and their bioactive components for neuroprotective activities against oxidative stress in cultured glioblastoma and neuroblastoma cells.
According to the tested analysis, the extracts and one of the purified components at a low dose protected the glial and neuronal cells from oxidation, an important activity that promotes neuron activity.
Furthermore, glutamate insult induced by oxidative stress was also inhibited by the application of Ashwagandha (WA) extracts (alcoholic and water) and their bioactive components.
Based on the findings, researchers said, "the combinations of extracts and active component were highly potent endorsing the therapeutic merit of the combinational approach".
And, "Ashwagandha leaf-derived bioactive compounds have neuroprotective potential and may serve as a supplement for brain health.s".
Taken altogether, Ashwagandha may be considered a functional herb for the promotion of brain functioning, pending the result of a larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combinations of Ashwagandha leaf extracts protect brain-derived cells against oxidative stress and induce differentiation by Shah N1, Singh R1, Sarangi U1, Saxena N1, Chaudhary A1, Kaur G2, Kaul SC1, Wadhwa R. (PubMed)
(2) Protective role of Ashwagandha leaf extract and its component withanone on scopolamine-induced changes in the brain and brain-derived cells by Konar A1, Shah N, Singh R, Saxena N, Kaul SC, Wadhwa R, Thakur MK. (PubMed)
#Healthyfood #Celeryextracts Protect the Liver Cells Against the Onset of #LiverCancer in Vivos, Researchers Say
By Kyle J. Norton
Scientists in the cancer research team have found a functional vegetable that may be the next pharmaceutical target to discover chemotherapy for the treatment of liver cancer.
Liver cancer is a medical and chronic condition characterized by cell growth disorderly and uncontrollably that starts on the surface of the inner lining of liver tissue as the result of an alternation of DNA.
At the early stage of liver cancer, most patients do not experience any symptoms. However, as cancer continues to grow, in some stages, it will suppress the nearby nerve cell to facilitate local pain and discomfort.
At the advanced stage, the liver cancerous cell can travel a distance away to infect other healthy tissue and organs through the circulation of blood and fluids.
Researchers do not know why the liver cells of some people are susceptible to DNA alternation, while others do not, even if they have the same health conditions, family history, and similar diet patterns.
Some researchers suggested that people who carry the infectious liver virus are associated with a major risk of liver cancer onset.
Researchers at the cancer program at the joint study led by the Technical University of Munich/Helmholtz Zentrum MĆ¼nchen in the confirmation of hepatitis B and C viruses risk of acute and chronic infections that can lead to liver cirrhosis and hepatocellular carcinoma (HCC) showed that the hepatitis B and C besides contributing to the development of liver cancer, they also cause over 1.3 million deaths per year worldwide.
According to the statistic, liver cancer is the second leading cause of cancer-related death worldwide, with HCC representing approximately 90% of all primary liver cancer cases.
Furthermore, patients who carry hepatitis B, and C are at an increased risk of liver cirrhosis, the early stage of liver cancer.
Moreover, in the reassessment of the relationship between the risk of liver cancer in hepatitis B and C carrier patients, researchers found that the majority of viral-associated HCC patients developed liver cirrhosis before liver cancer onset, however, the hepatitis B virus infection can promote HCC development without the prior end-stage liver disease.
Therefore, if you are a carrier of hepatitis B and C, please make sure that you know how to protect yourself against the risk of liver cancer.
Some researchers suggested the best protection for people who have been recently exposed to the hepatitis B and C virus and are not vaccinated, are usually given the vaccine along with a shot of hepatitis B immune globulin (HBIG) and a combination of antiviral drugs, respectively.
Celery is a species of Apium graveolens, belonging to the family Apiaceae.
The vegetable is cultivated all around the globe as a vegetable. Celery can grow to 1/2 m tall with stalks (leaf on the top) arranged in a conical shape joined at a common base.
Major phytochemicals found in celery include 3-n-butylphthalide, acetylenic, coumarins, phenolic acids, limonene, phthalides, and apigenin.
In the study to reaffirm the liver protective effect of celery seed, researchers launched an investigation to examine the anti-liver cancer activity of a methanolic extract of Apium graveolens seeds (celery seeds) on positive foci of gamma-GT in the liver of Wistar rats.
Application of celery seed extracts demonstrated a liver protective effect in a dose-dependent against toxins-induced hepatocarcinogenesis and gamma-GT positive foci in the rat treatment group.
5 days of pretreatment of celery seeds extracts stimulated the production of antioxidant enzymes in the host such as glutathione (GSH) and detoxifying enzymes such as quinone reductase (QR), glutathione-S-transferase (GST) and serum gamma-glutamyl transpeptidase (GGT) which were suppressed by the injection of toxins.
Dr. Sultana S, the lead author said, "A. graveolens is a potent plant against experimentally induced hepatocarcinogenesis in Wistar rats".
Furthermore, in the study of the liver-protective effects of perillyl alcohol, a monoterpene isolated from the essential oils of lavendin, peppermint, spearmint, cherries, celery seeds, and several other plants, the researchers found that
* Application of perillyl alcohol not only displays a significant activity against liver cancer but also inhibits the progression of pancreatic and mammary tumors.
* Perillyl alcohol actively induces apoptosis in liver tumor cells without affecting normal cells.
* Perillyl alcohol reverts tumor cells back to a differentiated state.
* Further differentiation indicated that Perillyl alcohol exerts the liver protective effect through activating the production of proteins responsible for programming cell death and deactivating the protein with function in pro-cellular survival.
Taken altogether, celery may be considered a functional food for the prevention of liver cancer and an adjunct therapy combined with the primary medicine for the treatment of liver cancer, depending on the large human sample size and multi-center studies.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(2) Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism, and altered hepatic foci development by Sultana S1, Ahmed S, Jahangir T, Sharma S(PubMed)
(3) Perillyl alcohol: applications in oncology by Belanger JT.(PubMed)
(4) Viral hepatitis and liver cancer by Marc Ringehan,1,2,3 Jane A. McKeating,4,5 and Ulrike Protzer. (PMC)
Scientists in the cancer research team have found a functional vegetable that may be the next pharmaceutical target to discover chemotherapy for the treatment of liver cancer.
Liver cancer is a medical and chronic condition characterized by cell growth disorderly and uncontrollably that starts on the surface of the inner lining of liver tissue as the result of an alternation of DNA.
At the early stage of liver cancer, most patients do not experience any symptoms. However, as cancer continues to grow, in some stages, it will suppress the nearby nerve cell to facilitate local pain and discomfort.
At the advanced stage, the liver cancerous cell can travel a distance away to infect other healthy tissue and organs through the circulation of blood and fluids.
Researchers do not know why the liver cells of some people are susceptible to DNA alternation, while others do not, even if they have the same health conditions, family history, and similar diet patterns.
Some researchers suggested that people who carry the infectious liver virus are associated with a major risk of liver cancer onset.
Researchers at the cancer program at the joint study led by the Technical University of Munich/Helmholtz Zentrum MĆ¼nchen in the confirmation of hepatitis B and C viruses risk of acute and chronic infections that can lead to liver cirrhosis and hepatocellular carcinoma (HCC) showed that the hepatitis B and C besides contributing to the development of liver cancer, they also cause over 1.3 million deaths per year worldwide.
According to the statistic, liver cancer is the second leading cause of cancer-related death worldwide, with HCC representing approximately 90% of all primary liver cancer cases.
Furthermore, patients who carry hepatitis B, and C are at an increased risk of liver cirrhosis, the early stage of liver cancer.
Moreover, in the reassessment of the relationship between the risk of liver cancer in hepatitis B and C carrier patients, researchers found that the majority of viral-associated HCC patients developed liver cirrhosis before liver cancer onset, however, the hepatitis B virus infection can promote HCC development without the prior end-stage liver disease.
Therefore, if you are a carrier of hepatitis B and C, please make sure that you know how to protect yourself against the risk of liver cancer.
Some researchers suggested the best protection for people who have been recently exposed to the hepatitis B and C virus and are not vaccinated, are usually given the vaccine along with a shot of hepatitis B immune globulin (HBIG) and a combination of antiviral drugs, respectively.
Celery is a species of Apium graveolens, belonging to the family Apiaceae.
The vegetable is cultivated all around the globe as a vegetable. Celery can grow to 1/2 m tall with stalks (leaf on the top) arranged in a conical shape joined at a common base.
Major phytochemicals found in celery include 3-n-butylphthalide, acetylenic, coumarins, phenolic acids, limonene, phthalides, and apigenin.
In the study to reaffirm the liver protective effect of celery seed, researchers launched an investigation to examine the anti-liver cancer activity of a methanolic extract of Apium graveolens seeds (celery seeds) on positive foci of gamma-GT in the liver of Wistar rats.
Application of celery seed extracts demonstrated a liver protective effect in a dose-dependent against toxins-induced hepatocarcinogenesis and gamma-GT positive foci in the rat treatment group.
5 days of pretreatment of celery seeds extracts stimulated the production of antioxidant enzymes in the host such as glutathione (GSH) and detoxifying enzymes such as quinone reductase (QR), glutathione-S-transferase (GST) and serum gamma-glutamyl transpeptidase (GGT) which were suppressed by the injection of toxins.
Dr. Sultana S, the lead author said, "A. graveolens is a potent plant against experimentally induced hepatocarcinogenesis in Wistar rats".
Furthermore, in the study of the liver-protective effects of perillyl alcohol, a monoterpene isolated from the essential oils of lavendin, peppermint, spearmint, cherries, celery seeds, and several other plants, the researchers found that
* Application of perillyl alcohol not only displays a significant activity against liver cancer but also inhibits the progression of pancreatic and mammary tumors.
* Perillyl alcohol actively induces apoptosis in liver tumor cells without affecting normal cells.
* Perillyl alcohol reverts tumor cells back to a differentiated state.
* Further differentiation indicated that Perillyl alcohol exerts the liver protective effect through activating the production of proteins responsible for programming cell death and deactivating the protein with function in pro-cellular survival.
Taken altogether, celery may be considered a functional food for the prevention of liver cancer and an adjunct therapy combined with the primary medicine for the treatment of liver cancer, depending on the large human sample size and multi-center studies.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(2) Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism, and altered hepatic foci development by Sultana S1, Ahmed S, Jahangir T, Sharma S(PubMed)
(3) Perillyl alcohol: applications in oncology by Belanger JT.(PubMed)
(4) Viral hepatitis and liver cancer by Marc Ringehan,1,2,3 Jane A. McKeating,4,5 and Ulrike Protzer. (PMC)
#Antioxidant #Betanin Inhibits the Risk of #Colitis Caused by Intestinal Mucosal #Inflammation, Researchers Say
By Kyle J. Norton
Colitis is a general term associated with the inflammation of the inner lining of the colon.
The disease can be caused by infection, inflammatory bowel disease (Crohn's disease (CD), ulcerative colitis(CD)), ischemic colitis, allergic reactions, and microscopic colitis.
Most cases of colitis are involved in the damage of the intestinal mucosal barrier, particularly to those of ulcerative colitis.
Epidemiologically, damage and a reduction of gut bacteria by dietary chemicals, such as antibiotics of the protective mucus layer and the underlying tissue by the poorly inactivated digestive proteases have been found to induce both UC and CD.
The intestinal mucosal barrier is the outermost layer of the lining of the intestines which plays an essential role to ensure the adequate containment of undesirable luminal contents within the intestine while preserving the ability to absorb nutrients.
Additionally, the intestinal mucosal barrier also processes various immunological mediators, including cytokines and chemokines stimulated by gut microbiota and host immune responses, thus maintaining a well-balanced relationship between gut microbes and the host immune system.
In other words, the intestinal mucosal barrier protects the colonic integrity by interacting with the gut microbiota and the immune response to prevent the inflammation of the colon that causes the onset of colitis.
Some researchers suggested disruption of the inaction of the immune system and gut microbiota caused by dysfunction of the intestinal mucosal barrier due to trauma, infection, neoplasia, and inflammation has been found to induce colitis in the experimental models.
Dr. K R Gardiner, the lead scientist in the examination of the mucosal barrier dysfunction as a feature of colitis irrespective of etiology or species wrote, "There were significantly increased systemic endotoxin concentrations in rats with acetic acid (7.5 (1.7-119.5) pg/ml), ethanol (13.7 (0-111.2) pg/ml), and hapten-induced (14.4 (5-31.1) pg/ml) colitis compared with saline controls (3.3 (0-13.7) pg/ml).
And, "There were significant correlations between the systemic endotoxin concentration and both the severity of colitis and of illness in acetic acid-induced colitis".
The finding strongly suggested that mucosal barrier dysfunction induces a significant increase in the chemical toxins involved in colitis development.
Betanin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
On finding a natural and bioactive compound with autophagy and anti-inflammation properties against the onset of colitis, researchers examined the effects of phytochemicals isolated from beetroot in an animal model.
The study included mice treated with intrarectal administration of 2,4,6-trinitrobenzenesulfonic acid (TNBS) (3.5 mg·20 g-1 ) induced colitis 2 or 4 days after treatment. Among the treated mice, some mice received trehalose (3% in drinking water 3 weeks before TNBS administration) or a daily administration of rapamycin (1.25 mg·kg-1, i.p.), betanin (1 g·kg-1, i.p.) or betanin + 3-methyladenine (3MA) (10 mg·kg-1, i.p.).
TNBS-treated mice alone showed impaired autophagy associated with body weight loss and intestinal damage.
Administration of trehalose, rapamycin, or betanin not only prevented the impaired autophagic flux induced by TNBS but also reduced the expression of pro-inflammatory cytokines in the intestinal mucosa.
The anti-inflammatory activity of trehalose, rapamycin, or betanin was also observed by a decrease in M1 macrophage markers.
The results suggested that betanin processes pharmacological stimulation of mucosal autophagy in reduced intestinal inflammation and improved murine colitis.
Furthermore, in patients with ulcerative colitis (UC) and Crohn's disease (CD). betanin also protected the colitic cells against oxidative DNA damage and induced apoptosis in neutrophils isolated from blood, through its antioxidant and anti-inflammatory properties.
The finding suggested that in normal intestinal cells, betanin protects the integrity of the cell against intestinal mucosal inflammation in the formation of colitis by inducing autophagy and anti-inflammatory effects.
Taken altogether, betanin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of colitis, pending the confirmation of the larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Stimulation of autophagy prevents intestinal mucosal inflammation and ameliorates murine colitis by Macias-Ceja DC1, CosĆn-Roger J2, Ortiz-MasiĆ” D2,3, Salvador P2, HernĆ”ndez C1,2, Esplugues JV1,2, Calatayud S2, Barrachina MD. (PubMed)
(2) DNA damage and apoptosis in blood neutrophils of inflammatory bowel disease patients and in Caco-2 cells in vitro exposed to betanin by ZieliÅska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Åuczak M4, Baer-Dubowska W. (PubMed)
(3) Colitis and colonic mucosal barrier dysfunction by K R Gardiner, N H Anderson, B J Rowlands, and A Barbul. (PMC)
Colitis is a general term associated with the inflammation of the inner lining of the colon.
The disease can be caused by infection, inflammatory bowel disease (Crohn's disease (CD), ulcerative colitis(CD)), ischemic colitis, allergic reactions, and microscopic colitis.
Most cases of colitis are involved in the damage of the intestinal mucosal barrier, particularly to those of ulcerative colitis.
Epidemiologically, damage and a reduction of gut bacteria by dietary chemicals, such as antibiotics of the protective mucus layer and the underlying tissue by the poorly inactivated digestive proteases have been found to induce both UC and CD.
The intestinal mucosal barrier is the outermost layer of the lining of the intestines which plays an essential role to ensure the adequate containment of undesirable luminal contents within the intestine while preserving the ability to absorb nutrients.
Additionally, the intestinal mucosal barrier also processes various immunological mediators, including cytokines and chemokines stimulated by gut microbiota and host immune responses, thus maintaining a well-balanced relationship between gut microbes and the host immune system.
In other words, the intestinal mucosal barrier protects the colonic integrity by interacting with the gut microbiota and the immune response to prevent the inflammation of the colon that causes the onset of colitis.
Some researchers suggested disruption of the inaction of the immune system and gut microbiota caused by dysfunction of the intestinal mucosal barrier due to trauma, infection, neoplasia, and inflammation has been found to induce colitis in the experimental models.
Dr. K R Gardiner, the lead scientist in the examination of the mucosal barrier dysfunction as a feature of colitis irrespective of etiology or species wrote, "There were significantly increased systemic endotoxin concentrations in rats with acetic acid (7.5 (1.7-119.5) pg/ml), ethanol (13.7 (0-111.2) pg/ml), and hapten-induced (14.4 (5-31.1) pg/ml) colitis compared with saline controls (3.3 (0-13.7) pg/ml).
And, "There were significant correlations between the systemic endotoxin concentration and both the severity of colitis and of illness in acetic acid-induced colitis".
The finding strongly suggested that mucosal barrier dysfunction induces a significant increase in the chemical toxins involved in colitis development.
Betanin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
On finding a natural and bioactive compound with autophagy and anti-inflammation properties against the onset of colitis, researchers examined the effects of phytochemicals isolated from beetroot in an animal model.
The study included mice treated with intrarectal administration of 2,4,6-trinitrobenzenesulfonic acid (TNBS) (3.5 mg·20 g-1 ) induced colitis 2 or 4 days after treatment. Among the treated mice, some mice received trehalose (3% in drinking water 3 weeks before TNBS administration) or a daily administration of rapamycin (1.25 mg·kg-1, i.p.), betanin (1 g·kg-1, i.p.) or betanin + 3-methyladenine (3MA) (10 mg·kg-1, i.p.).
TNBS-treated mice alone showed impaired autophagy associated with body weight loss and intestinal damage.
Administration of trehalose, rapamycin, or betanin not only prevented the impaired autophagic flux induced by TNBS but also reduced the expression of pro-inflammatory cytokines in the intestinal mucosa.
The anti-inflammatory activity of trehalose, rapamycin, or betanin was also observed by a decrease in M1 macrophage markers.
The results suggested that betanin processes pharmacological stimulation of mucosal autophagy in reduced intestinal inflammation and improved murine colitis.
Furthermore, in patients with ulcerative colitis (UC) and Crohn's disease (CD). betanin also protected the colitic cells against oxidative DNA damage and induced apoptosis in neutrophils isolated from blood, through its antioxidant and anti-inflammatory properties.
The finding suggested that in normal intestinal cells, betanin protects the integrity of the cell against intestinal mucosal inflammation in the formation of colitis by inducing autophagy and anti-inflammatory effects.
Taken altogether, betanin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of colitis, pending the confirmation of the larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Stimulation of autophagy prevents intestinal mucosal inflammation and ameliorates murine colitis by Macias-Ceja DC1, CosĆn-Roger J2, Ortiz-MasiĆ” D2,3, Salvador P2, HernĆ”ndez C1,2, Esplugues JV1,2, Calatayud S2, Barrachina MD. (PubMed)
(2) DNA damage and apoptosis in blood neutrophils of inflammatory bowel disease patients and in Caco-2 cells in vitro exposed to betanin by ZieliÅska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Åuczak M4, Baer-Dubowska W. (PubMed)
(3) Colitis and colonic mucosal barrier dysfunction by K R Gardiner, N H Anderson, B J Rowlands, and A Barbul. (PMC)
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