#Herbal #Artichokes Inhibit the Parameters that Cause #NonalcoholicFattyLiverDisease (#NAFLD), Researchers Say

By Kyle J. Norton

Artichoke may be used as a herbal remedy for the treatment of nonalcoholic fatty liver disease with no side effects, according to studies.
Nonalcoholic fatty liver disease is a fatty liver disease caused by fat accumulated in the liver other than those of excessive alcohol drinking.

The disease, in most cases, is asymptomatic, however, it has been seen to slowly progress to end-stage liver disease.

According to the statistics, non-alcoholic fatty liver disease affects over 25% of the US population.

Epidemiological studies suggested that most cases of nonalcoholic fatty liver disease are found in obese and extremely overweight adults. However, people with diabetes, high cholesterol, or high triglycerides are associated with an increased risk of the disease. Indeed, 75% of obese have steatosis and 20% to 35% have nonalcoholic steatohepatitis (NASH).

As of today, there is no effective treatment in patients with NAFLD, change of diet and lifestyle to induce weight loss are the most common nonmedical treatment conventionally for the management of the disease.

Some researchers suggested that the cause of NAFLD may be associated with the promotion of the Western diet over the past few decades.

Dr. Michael D. Roberts, the lead scientist in the evaluation of the Western diet risk in NAFLD, wrote, "...sub-chronic WD feeding appears to increase hepatic steatosis development over a 6-week period but only induces select inflammation-related liver transcripts, mostly acute phase response genes".

And, "diet-induced liver fibrosis and inflammation may either: a) occur much later with more chronic WD rat feeding paradigms, and/or b) may be initiated by other factors that precede eventual perturbations in local and systemic pro-inflammatory signalers with chronic WD feeding".

The results strongly suggested the Western diet pattern has a strong impact on the development of non-alcoholic fatty liver disease.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae, native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.


Scientists on finding a natural ingredient for the treatment of nonalcoholic fatty liver disease examined the artichoke (JA) potential in attenuating lipid disturbances in an animal model.

The study included Wistar of rats fed a control diet, a 60 % fructose-enriched diet (FRU), or an FRU with 10 % JA (n 6-7) for 4 weeks.

After 21 days of the experiment, according to the liver samples collected, the JA treatment group showed a significant improvement in a hepatic TAG accumulation, an indication of a fatty liver.

The expression of fat accumulation in the tested rats was observed by the expression of malic enzyme 1 (Me1), associated with fatty acid synthesis; decorin (Dcn), related to fibrosis altered by the FRU.

Additionally, the injection of the supplement also improved the gene associated with liver inflammation caused by FRU.

Furthermore, in order to reveal more information about artichoke anti-NAFLD, researchers conducted a randomized double-blind placebo-controlled parallel-group trial in ultrasound-diagnosed NAFLD.

100 subjects were randomized to either ALE 600 mg daily or placebo for a 2-month period.

Injection of AlE showed increased hepatic vein flow (p < .001), reduced portal vein diameter (p < .001), and liver size and levels of liver oxidative stress markers.

The ALE-treated group improved liver function by reducing the expression of the levels of bilirubin.

More importantly, ALE supplementation also reduced total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and triglyceride concentrations.

The results showed that artichoke anti-NALFD via several mechanisms, including the inhibition of levels of cholesterol and liver stress markers.

Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of non-alcoholic fatty liver disease, pending the confirmation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Beneficial effects of soluble dietary Jerusalem artichoke (Helianthus tuberosus) in the prevention of the onset of type 2 diabetes and non-alcoholic fatty liver disease in high-fructose diet-fed rats by Chang WC1, Jia H2, Aw W2, Saito K2, Hasegawa S3, Kato H1. (PubMed)
(2) Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial by Panahi Y1, Kianpour P2, Mohtashami R3, Atkin SL4, Butler AE5, Jafari R6, Badeli R7, Sahebkar A. (PubMed)
(3) Western diet-induced hepatic steatosis and alterations in the liver transcriptome in adult Brown-Norway rats by Michael D. Roberts, C. Brooks Mobley, Ryan G. Toedebush, Alexander J. Heese, Conan Zhu,Anna E. Krieger, Clayton L. Cruthirds, Christopher M. Lockwood, John C. Hofheins,Charles E. Wiedmeyer, Heather J. Leidy, Frank W. Booth, and R. Scott Rector/ (PMC)

#Healthyfood #BroccoliSprouts In the Promotion of the Production of #Antioxidantenzymes Against #SickleCellDisease (SCD), According to Studies

By Kyle J. Norton

Anemia is a medical condition associated with a lack of healthy red blood cells or hemoglobin in the blood.
Iron deficiency anemia is one of the most common anemia, caused by poor iron levels in the blood, leading to the reduced delivery of oxygen throughout your body.

A long-term deficiency of folate and vitamin B-12 plays a critical role in the production of healthy red blood cells associated with an increased risk of Amenia.

Also, people with the mutated gene inherited from the parent are at substantial risk of the disease. The Duliajan College study suggested that certain genes have been found to induce anemia.

Sickle cell anemia (SCD), a genetic preposition form of anemia is a condition associated with not enough healthy red blood cells to carry adequate oxygen throughout your body.

The red blood cells in sickle cell anemia patines are rigid and sticky with the shapes of sickles or crescent moons.

Normal red blood cells live for about 120 days compared to sickle cells that die in 10 to 20 days. In other words, the inability of the body to replace the cell that dies rapidly with new blood cells is a cause of sickle cell anemia.

According to the statistics, provided by the CDC, approximately 100,000 Americans are living with SCD. Ethnically, 1 out of every 365 Black or African-American births, 1 out of every 16,300 Hispanic-American births, and 1 in 13 Black or African-American birth are sickle cell trait (SCT) carriers.


Conventionally, except for bone marrow transplants, treatments of sickle cell anemia are to improve quality of life, by relieving symptoms and preventing complications.

Collard Green is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.

With an aim to find a potential ingredient for the treatment of inherited blood disorder, researchers examined the effects of broccoli sprout homogenate (BSH) containing sulforaphane and sulforaphane in the activation of NRF2 on sickle cell disease (SCD).

Nrf2 is a protein that processes the function in the regulation of the expression of antioxidant enzymes against oxidative damage triggered by injury and inflammation.

According to the tested analysis, sulforaphane (SFN) significantly increased the expression of NRF2 associated with the increase of antioxidant enzymes that inhibits oxidative stress such as HMOX1, NQO1, and HBG1 in a dose-dependent manner.

In adults with SCD,
* BSH consumption showed no adverse effects.

* BSH consumption increases the mean relative whole blood mRNA levels NRF2 target HMOX1

* Furthermore, BSH injection increased mean relative mRNA levels of the NRF2 target HBG1, compared to the baseline at the end of treatment, without affecting the levels of HbF protein.


In other words, BSH displays a similar effect compared to that of sulforaphane in the promotion of the production of antioxidant enzymes against sickle cell disease (SCD).

Based on the findings, researchers said, "BSH, in the provided doses, is safe in stable SCD patients and may induce changes in gene expression levels".

Taken altogether, broccoli sprouts processed abundantly SFN may be considered a functional food for the treatment of SCD, pending the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phase 1 Study of a Sulforaphane-Containing Broccoli Sprout Homogenate for Sickle Cell Disease by Doss JF1,2, Jonassaint JC3, Garrett ME4, Ashley-Koch AE4, Telen MJ3, Chi JT. (PubMed)

#Herbal #Turmericextracts Inhibits the Risk of #Uveitis, According to Studies

By Kyle J. Norton

Uveitis is a type of eye inflammation, affecting the middle layer of tissue in the eye wall (uvea).
The condition has been found to onset suddenly and get worse quickly. The most common symptoms of uveitis are eye redness, pain, and blurred vision that can affect one or both eyes.

In some cases, patients with the condition also experience symptoms of light sensitivity, floaters, and decreased vision.

If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.


The exact cause of uveitis is unknown. However, some researchers suggested that people with a compromised immune system associated with inflammatory disease and infected diseases are at an increased risk of uveitis.

Other risk factors, epidemiologically such as eye injury, diseases that affect the eye such as diabetes are also found in patients with uveitis.

Most cases of uveitis are treated by prescription eye drops in combination with anti-inflammatory medications. If all fail, surgery may be necessary.

Untreated uveitis has been found to induce complications of glaucoma, cataracts, optic nerve damage, and retinal detachment.

Out of the prevalent factors of uveitis, some researchers suggested that aging associated with the weakened immune system may be the major factor that causes uveitis.


Dr, Marwan R. Abdulaal, the lead scientist said, "Uveitis is a vision-threatening inflammation of the eye that carries considerable morbidity. It is responsible for 10% of legal blindness in the United States and up to 25% in the developing world".

And. "The aging body has a changing response of the immune system, which might reflect a different pattern of uveitis in the elderly population".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In finding a natural compound for the treatment of uveitis, researchers examined the effect on turmeric administered 4 h after induction of E. coli lipopolysaccharide-induced uveitis in rats.
Compared to the control group, turmeric showed significantly suppressed inflammation with a significantly lower mean clinical grade, histopathological grade, and aqueous humor (AH) protein level, second to the conventional medicine prednisolone.

The turmeric administered for 4 h did not affect proinflammatory cytokines levels of TNF-alpha levels.

However, when the aqueous extract was administered starting 3 days before induction of uveitis, the treatment group not only showed a similar effect on the mean clinical and histopathological grade, as well as AH protein but also reduced TNF-alpha levels, comparable to the treatment group.

Based on the findings, researchers said, "topically applied a standardized aqueous extract of C. longa suppresses endotoxin-induced uveitis in rats by reducing TNF-alpha activity".

In order to reveal more information about turmeric anti-uveitis properties, researchers examined the anterior uveitis induced in rabbits by intravitreal injection of lipopolysaccharide from Escherichia coli after pretreatment with C. longa and B. aristata aqueous extracts.

According to the clinical and histopathologic grading, anterior segment inflammation in the control group was significantly higher compared to both the extract-treated groups.

More precisely, the inflammatory cell count in the control group was 30.75 cells/mL compared to 2.39 and 11.56 cells/mL in the C. longa- and B. aristata-treated groups, respectively.

Similarly, C. longa- and B. aristata-treated groups also exerted strong effects on the protein content and TNF-alpha level as of that in the aforementioned study.

Taken altogether, turmeric may be considered a supplement for the prevention and treatment of uveitis, pending the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Topically applied standardized aqueous extract of Curcuma longa Linn. suppresses endotoxin-induced uveal inflammation in rats by Agarwal R1, Gupta SK, Agarwal P, Srivastava S. (PubMed)
(2) The anti-inflammatory effects of Curcuma longa and Berberis aristata in endotoxin-induced uveitis in rabbits by Gupta SK1, Agarwal R, Srivastava S, Agarwal P, Agrawal SS, Saxena R, Galpalli N. (PubMed)
(3) Uveitis in the Aging Eye: Incidence, Patterns, and Differential Diagnosis by Marwan R. Abdulaal, Bachir H. Abiad, and Rola N. Hamam. (PMC)

#Phytochemical #Allicin Processes FreeRadicalScavenging Activities, Researchers Show

By Kyle J. Norton

Phytochemicals may be the next potential source of new medications for the treatment of diseases with little or no side effects.
Scientists may have found a dietary and bioactive ingredient for the prevention and treatment of diseases associated with oxidative stress.

Allicin is phytochemical containing sulfur in the class of organosulfur compounds, found abundantly in onion and garlic.

Oxidative stress is a condition characterized by the overexpression of free radicals in the host body.

Most cases of oxidative stress are caused by the inability of the host liver in stimulating the production of antioxidant enzymes which play a critical role in inhibiting the free radical expression, causing oxidative stress.

In a healthy individual, the ratio of free radicals and antioxidant enzymes is always balanced.

However, an individual whose antioxidant enzymes were suppressed due to damage to the antioxidant enzymes' productive system or other sources may have a greater risk of the onset of oxidative stress.

Dietary antioxidant intake such as fruits and vegetables may be helpful to keep the free radical in check.

Oxidative stress has been found to cause damage to cell lipids, proteins, and DNA, leading to many chronic diseases, including atherosclerosis, cancer, diabetics, rheumatoid arthritis, post-ischemic perfusion injury, myocardial infarction, cardiovascular diseases, chronic inflammation, and stroke.

The oxidative stress that causes chronic ailment is a result of a chain reaction started by free radical donating or stealing an electron from another atom, leading to a domino effect that can not be stopped until all outer ring electron of free radicals is paired or inhibited by antioxidants.

A free radical is any atom or molecule that has a single unpaired electron in an outer shell and highly reactive to react with another cell.

Most free radicals and other ROS are derived internally either from normal essential metabolic processes in the human body or from external sources such as exposure to X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals.



Antioxidants are biomolecules that inhibited oxidation.
On finding a natural ingredient and whole food for the prevention and treatment of diseases associated with oxidative stress, researchers investigated the effect of allicin (the active ingredient of garlic) contained in the commercial preparation of Garlicin against hydroxyl radicals (.OH) using high-pressure liquid chromatographic (HPLC) method.

Allicin is equivalent in Garlicin (1.8, 3.6, 7.2, 14.4, 21.6, 28.8, and 36 micrograms) produced concentration-dependent decreases in the formation of 2,3-DHBA and 2,5-DHBA, the OH adduct products.

The inhibition of the formation of 2,3-DHBA and 2,5-DHBA with 1.8 micrograms/ml was 32.36% and 43.2% respectively while with 36.0 micrograms/ml, the inhibition was approximately 94.0% and 90.0% respectively.

These results suggested that allicin is highly active against the OH adduct products through its free radical scavenging activity.

Furthermore, Allicin also exerted a significant antioxidant activity by preventing the lipid peroxidation of liver homogenate in a concentration-dependent manner.

Additionally, by examing the antioxidant effects of four main chemical classes, alliin, allyl cysteine, allyl disulfide, and allicin, prepared by chemical synthesis or purification, researchers discovered
* Alliin scavenged superoxide, while allyl cysteine and allyl disulfide did not react with superoxide.

* Allicin suppressed the formation of superoxide by the xanthine/xanthine oxidase system, probably via a thiol exchange mechanism.

* Allicin did not exhibit hydroxyl radical scavenging activity in this study, probably due to some unknown mechanisms.

The finding suggested that allyl disulfide, alliin, allicin, and allyl cysteine exhibit different patterns of antioxidant activities as protective compounds against free radical damage.

Taken altogether, allicin-processed high levels of free radicals scavenging activity may be used for the prevention of the overexpression of ROS in the initiation of oxidative stress.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antioxidant activity of allicin, an active principle in garlic by Prasad K, Laxdal VA, Yu M, Raney BL. (PubMed)
(2) The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide by Chung LY. (PubMed)

#WildCarrots Exhibit the Apoptosis of #SkinCancer in Vivos, Researchers Suggest

By Kyle J. Norton

Carrots may have a profound and substantial effect in reducing the risk, progression, and treatment of skin cancer, some scientists suggested.

Skin cancer is a condition characterized by cell growth disorderly and uncontrollably in skin tissue. At the later stage, the cancerous cells may infect other healthy tissue and organ a distance away from the original site.

Carrot, a root vegetable with orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asia and Europe.

In the investigation of essential oil isolated from wild carrot umbels effect in mice induced skin cancer through injection of 7,12-dimethyl benz(a)anthracene (DMBA), after 20 weeks of administered to animals via gavage (0.02 mL of 100% oil), intraperitoneal (0.3 mL of 2% oil), and topical (0.2 mL of 5, 50, and 100% oil) with half-maximal inhibitory concentration IC50, researchers showed that topical administration of 100% mice group exerted in delay skin cancer appearance and inhibited tumor incidence of 89%.

With the concentration of IC40, topical 50% and 5% treatment inhibited tumor incidence by 83% and 36%, respectively.


Topical ingestion of 100, 50, and 5% oil, also revealed a significant decrease of tumor volume by 99, 91, and 70%, respectively.

Intraperitoneally, treatment mice displayed an inhibited tumor by 43% and decreased tumor volume by 85%, whereas gavage treatment showed minimal effects on both.

These results suggested that intraperitoneal and topical treatment of wild carrot essential oil decreased infiltration and proliferation with an increase in abnormal thickening of the outer layer of the skin.

Further analysis of the wild carrot essential oil anti-cancer effect on human epidermal keratinocytes and the chemopreventive activity of the pentane diethyl ether fraction on DMBA/TPA-induced skin carcinogenesis in mice, scientists in the joint study lead by the Lebanese American University suggested that application of all fractions isolated from the essential oil exhibited significant cytotoxicity, with HaCaT cells being 2.4-3 times less sensitive than HaCaT-ras A5 (benign tumorigenic), and HaCaT-ras II4 (malignant) cells observed by western blot.

In Gas chromatography-mass spectrometry, 2-himacharlen-6-ol. a derivative isolated from pentane/diethyl ether fraction (F2), demonstrated strong inhibition of HaCaT-ras A5 and HaCaT-ras II4 cells through cell cycle arrest in the accumulation of cells of the sub-G1 apoptotic phase and apoptosis in decreased the population of cells in the S and G2/M phases.

These results were attributed to the F2 fraction in enhanced expression of pro-apoptotic (Bax) in induction cellular apoptosis and attenuated expression of anti-apoptotic (Bcl2) proteins in promoted cancer proliferation.

Interestingly, all fractions also decreased the phosphorylation of AKT, (AKT is an essential component of the PI3K (phosphatidylinositol 3-kinase pathway) in monitoring skin cancer cell growth and resistance to apoptosis and ERK(components of mitogen-Activated Protein Kinase (MAPK) signaling pathways) in mediated different anti-proliferative events, such as apoptosis, autophagy, and senescence.

Based on the information fonding, Dr. Shebaby WN, the lead author said, " F2 fraction has remarkable antitumor activity against DMBA/TPA-induced skin carcinogenesis, an effect that may be mediated through inhibition of the MAPK/ERK and PI3K/AKT pathways".

The above differentiation was supported by the joint study led by the University of Surrey in the evaluation of Daucus carota oil extract (DCOE) activity in the inhibition of HaCaT-ras II-4 epidermal squamous cells.

According to the experiment, β-2-himachalen-6-ol isolated from the wild carrot essential oil at dose-dependent decreased in skin cell survival with an IC50 and IC90 of 8 and 30 μg/ml, respectively.

Observation of Flow cytometry analysis also revealed that treatment of β-2-himachalen-6-ol is linearly associated with volume injection, as the dose of 10 μg/ml HC significantly increased the number of cells undergoing late apoptosis (28%), while 25 μg/ml caused a larger cell shift towards late apoptosis (46.6%) and necrosis (39%).

Besides decreasing the phosphorylation of AKT, and ERK as shown in the mentioned above, β-2-himachalen-6-ol also inhibited the significant decrease in protein levels of p53 and Bcl-2 in acting as tumors suppressor, caused by 7,12-Dimethylbenz[a]anthracene (DMBA)/ 12-O-tetradecanoylphorbol-13-acetate (TPA) and increased p21 and Bax function in cell cycle arrest and activation of apoptosis.

Astonishingly, the application of essential oil extract from wild carrot inhibited skin cancer proliferation and induced apoptosis withing harming the nearby healthy cells in tested mice.

Taken together, the essential oil of carrot and its bioactive derivative may be considered as an adjunct therapy in reduced risk, and progression and used a combination with standard medicine for the treatment of skin cancer.

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including world wide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
(1) Chemopreventive effects of wild carrot oil against 7,12-dimethyl benz(a)anthracene-induced squamous cell carcinoma in mice by Zeinab RA1, Mroueh M, Diab-Assaf M, Jurjus A, Wex B, Sakr A, Daher CF(PubMed)
(2) Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer by Shebaby WN1, Mroueh MA2, Boukamp P3,4, Taleb RI1, Bodman-Smith K5, El-Sibai M1, Daher CF(PubMed)
(3) β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo by Daaboul HE1, Daher CF2, Taleb RI2, Boulos J2, Bodman-Smith K1, Boukamp P3,4, Shebaby WN2, Dagher C5, El-Sibai M2, Mroueh MA(PubMed)

#Herbal #Ashwagandha Protects the Neurons Against the Onset of #Alzheimer's and #Parkinson's Diseases, According to Studies

By Kyle J. Norton

The central system is the complex of nerve tissues including the brain and spinal cord with functions to respond to the integrating sensory information.
Neuroinflammation is a process of the immune system's response to harmful pathogens that induced oxidative stress in the brain.

Neuroinflammation is also the inflammation of nervous tissue associated with the immune response in the first phase of infection including infection, traumatic brain injury, toxic metabolites, or autoimmunity.

Neurological disorders are a class of diseases associated with the brain, and the spinal cord including the nerves that connect them.

The most common diseases of the neurological disorder are dementia, including ALS. PD, Alzheimer's disease, birth defects of the brain and spinal cord, brain injury, and tumors.

Back pain associated with related nerve damage is one of the common complaints in the US that send many patients to seek help from their doctor. Believe it or not, 80% of the US population will experience back pain at some time in their lives.

There is no single cause of neuro-dysfunction. Lifestyle, infections, genetics, nutrition-related disease, environment, and physical injuries have been found to be some major prevalent factors that induce the onset of neurological abnormalities.

Furthermore, neurological disorders have been found to facilitate psychological symptoms such as anxiety and depression and physical symptoms, depending totally on the neurons affected, including partial or complete paralysis muscle weakness seen in post-stroke patients, difficulty reading and writing, and poor cognitive abilities such as patients with dementia.

According to the American Addiction Center, if you experience some of the below symptoms persistently, including headaches, blurry vision, persistent fatigue, changes in behavior, numbness in the legs or arms, changes in coordination or balance weakness, slurred speech and tremors, you should seek help from the professionals immediately, as these may be the first signs of neurological disorders.

Neurodegenerative diseases are the most common forms of low-grade chronic neuroinflammation, including Alzheimer's disease, vascular dementia, and dementia with Lewy bodies.

Dr. WEI-WEI CHEN, the lead scientist at the Xuzhou Central Hospital in the investigation of inflammatory cytokines and chronic neuroinflammation wrote, "Accordingly, pro-inflammatory cytokines are important in the pathophysiology of depression and dementia"

And, "These data suggest that the role of neuroinflammation in neurodegeneration must be fully elucidated, since pro-inflammatory agents, which are the causative effects of neuroinflammation, occur widely, particularly in the elderly in whom inflammatory mechanisms are linked to the pathogenesis of functional and mental impairments.".

Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for enhancing brain performance, researchers examined the ashwagandha effects on the neurons.

Epidemiologically, environmental stressors have been found to cause global concerns in modern society, by rapidly increasing the incidence of a variety of pathological conditions including brain tumors, and neurodegenerative & neuropsychiatric disorders.

Ashwagandha used in Indian traditional home medicine showed to process the anti-stress and remedial potential for the treatment of aging and neurodegenerative pathologies, including environmental toxins.

Furthermore, Ashwagandha extracts and their active principles also exerted the underlying molecular mechanism(s) that inhibits brain pathologies through the herb's nootropic potency.

Moreover, in examing the Ashwagandha leaf extracts effects, researchers found that the Ashwagandha inhibited neuroblastoma and glioma cell initiation, and reversal of Alzheimer's and Parkinson's pathologies, protected against environmental neurotoxins, and enhancement of memory.

Taken altogether, Ashwagandha may be considered a functional herb that increases body mass and strength in resistance training, pending the result of a larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Nootropic potential of Ashwagandha leaves: Beyond traditional root extracts by Wadhwa R1, Konar A1, Kaul SC. (PubMed)
(2) Role of neuroinflammation in neurodegenerative diseases (Review) by Chen WW1, Zhang X1, Huang WJ. (PubMed)

#Phytochemical 3,3'-Diindolylmethane Inhibits the Risk of #ProstateCancer, According to Researchers

By Kyle J. Norton

Scientists may have found a plan-based bioactive compound for the treatment of prostate cancer with no side effects, according to studies.
Prostate cancer is a medical condition caused by cell growth disorderly in the tissue of the prostate glands. Prostate cancer is one of the most slow-growing cancers that take years to develop.

The disease often is discovered during the rectum examination annually. Most cases of prostate cancer start in the cells on the surface of the inner lining of prostate tissue.

In the early stage, patients may not experience any symptoms. However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine and semen, disruption of urinary passing, and frequent and urge urinary.

In severe cases, prostate cancer can also cause erectile dysfunction.

According to statistics, 1 man in 9 will be diagnosed with prostate cancer during his lifetime.

Most cases ( about 60%) of prostate cancer are found in older men, particularly in the African-American. The 5-year survival rate of local or regional prostate cancer is nearly 100.


Out of many risk factors, an unhealthy diet may be one of the major risk factors associated with the onset of the disease.

Some researchers in the study of the preventive diet against prostate cancer wrote, " Although the available data are not entirely consistent, possible preventative behavioral factors include increased physical activity, intakes of tomatoes, cruciferous vegetables, and soy. Factors that may enhance prostate cancer risk include frequent consumption of dairy products and, possibly, meat".

" By comparison, alcohol probably exerts no important influence on prostate cancer development. Similarly, dietary supplements are unlikely to protect against the onset of prostate cancer in healthy men".

"Several factors, such as smoking and obesity, show a weak association with prostate cancer incidence but a positive relation with prostate cancer mortality. Other factors, such as fish intake, also appear to be unassociated with incident prostate cancer but show an inverse relation with fatal prostate cancer".

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.

Researchers on finding a natural compound for the treatment of prostate cancer examined the effect of 3,3'-Diindolylmethane (DIM) as tumor inhibitors in multiple malignant tumors on microRNAs (miRNAs).

Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) application showed a significant effect in the inhibition of proliferation and invasion of prostate cancer cells.

Furthermore, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment induced cancer death by inhibiting the expression level of CYP1A1, an enzyme associated with the activation of the compounds with carcinogenic properties.

In other words, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment activated the expression of MAP3K12 in the promotion of cancer cells by targeting the mRNA of miR-150-5p in prostate cancer cells.

Moreover, in order to reveal more information about DIM anti-prostate cancer activity, researchers examine the modulation of the immune system by cancer-protective food bio actives, indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM).

Injection of indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), exerted prostate cell protective effect by the regulation of inflammatory responses in monocytes and macrophages of the immune system.

In other words, I3C and DIM inhibited the lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria in the induction of IL-1β mRNA associated with the immune response to infection and protein in the monocyte form of the white blood cells.


I3C and DIM also exerted anti-inflammatory activity by inhibiting the expression of gene CD84 mRNA in signaling T-cell activation by regulating the proteins associated with the expression of the gene.

Dr. Wang TTY and colleagues after taking into account co and confounders, wrote, "cross-talk between AHR(protein associated with regulating gene expression) and inflammation-mediated pathways, but not CD84-mediated pathways, in monocytes but not macrophages may contribute to the modulation of tumor environments by I3C and DIM in prostate cancer'.

The results strongly suggested that DIM modulated the immune function against the process of prostate cancer development and progression.

Taken altogether, DIM may be considered a supplement for the prevention and combined with primary medicine for the treatment of prostate cancer, pending the confirmation of a larger sample size and multicenter human study.


Intake of DIM in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12 by Yu J1, Feng Y1, Wang Y1, An R. (PubMed)
(2) Elucidating the Role of CD84 and AHR in Modulation of LPS-Induced Cytokines Production by Cruciferous Vegetable-Derived Compounds Indole-3-Carbinol and 3,3'-Diindolylmethane by Wang TTY1, Pham Q2, Kim YS. (PubMed)
(3) Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates by Michael F Leitzmann1 and Sabine Rohrmann. (PMC)