By Kyle J. Norton
Human toxicity is a general term that refers to any substance which causes harm to human health if inhaled, ingested, or absorbed through the skin.
Liver toxicity is a process that causes liver damage by reducing the function of the liver.
Liver oxidative stress caused by a toxic substance such as an overdose of the supplement has been found to constitute most cases of acute liver damage.
The liver is the largest internal organ that not only filters the blood from the digestive system before passing them to other parts of the body but also plays a critical role in the production of cholesterol, a waxy substance that aids digestion, builds cell membranes, and produces vitamin D and steroid hormones.
Liver stress is a condition in which the function of the liver is partly reduced. Hepatic stress can be observed by the levels of liver stress-makers, including transaminases aspartate transaminase (AST) and alanine transaminase (ALT).
Abnormal high levels of transaminases aspartate transaminase (AST) and alanine transaminase (ALT) are early indications of liver damage or injury.
Epidemiologically, drugs that induce liver injury are nonsteroidal anti-inflammatory drugs (NSAIDs), anti-infective drugs (anti-tubercular drugs), anti-cancer drugs, hormonal drugs, immunosuppressive agents, sedative and neuropsychiatric drugs.
Acetaminophen according to study is the most form of medication that implicates drug-induced liver injury
However, antibiotics are the class of drugs that cause liver toxicity most commonly
Conventionally, treatment of liver toxicity is totally depending on the types of inducers, including
* Management of drug-induced liver injury by discontinuing the suspected drug.
* Acetaminophen poisoning is treated by the antidote N-acetylcysteine.
* Glucocorticoids are used for the treatment of immune-mediated drug-induced liver injury.
And,
* Intravenous N- acetylcysteine is used for the treatment of non-acetaminophen-related acute liver failure
Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
On finding a potential compound for the prevention of liver injury, researchers investigated the potential oxidative damage of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in hepatic microsomal fractions in an animal model.
The study included rat liver microsomes that were divided into four groups.
* Group I served as a control and is incubated with vehicle (toluene).
* Groups II and IV incubated with 20 µM lycopene for 1 h before further incubating; and
* Groups III and IV with 15 nM of TCDD for a further 1 h.
Based on the tested analysis, groups treated with TCDD showed a significant increase in liver oxidative stress observed by increasing levels of Hydrogen peroxide (H2O2) production, lipid peroxidation (LPO),
Protein carbonyl content and activities of uridine 5'-diphosphate-glucuronyltransferase (UDPGT) and P450 associated with liver damage also increased substantially in the TCDD treatment groups.
Furthermore, the activity of antioxidant enzymes superoxide dismutase, glutathione peroxidase, catalase, glutathione-S-transferase, and glutathione reductase, and the microsomal thiol content produced by the rat liver microsomes were significantly decreased in the TCDD treatment groups.
Lycopene treatment group IV not only normalized the activities of the enzymes, thiol, and carbonyl content but also significantly reduced LPO and H2O2 production.
These results suggested that TCDD induced liver toxicity by increasing the levels of free radicals and decreasing the antioxidant activity in rat liver microsomes.
Based on the findings, researchers concluded, "TCDD induces significant oxidative stress in liver microsomes as manifested by increased LPO, H2O2 production, protein carbonyl content and activities of UDPGT and P450 and decreased antioxidant enzymes activities and thiol content".
Taken altogether, lycopene found in tomatoes may be considered supplements for the prevention and treatment of liver toxicity, pending the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene: Hepatoprotective and Antioxidant Effects toward Bisphenol A-Induced Toxicity in Female Wistar Rats by Abdel-Rahman HG1, Abdelrazek HMA2, Zeidan DW3, Mohamed RM4, Abdelazim AM. (PubMed)
(2) Ameliorative effect of lycopene against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced rat liver microsomal toxicity: an in vitro study by Aly HA1, El-Shitany NA2, El-Beshbishy HA3, Ashour OM. (PubMed)
(3) Liver Toxicity by Anam Bashir, and Dhruv Mehta. (NCBI)
Wednesday, 7 June 2023
Long-Term intake of #Herbal #Alfalfa May Increase the Risk of #ColonTumors, Researchers Suggest
By Kyle J. Norton
Scientists do not agree that herbal Alfalfa can be used alone or combined with other primary medicine for the treatment of cancer, according to a study.
Cancer is a class of diseases characterized by cell growth irregularly and disorderly in the body tissue.
Most cases of cancer start in the cell on the surface of the inner lining of the tissue of the organ. In the early stage, due to the small size of the tumor, most patients do not experience any symptoms.
However, in the advanced stage, most cancer can cause bleeding and serious pain if the large size has pressed on the blood vessels and nearby nerve cells. In this stage, cancerous cells may travel a distance away from the original site to infect other tissue and organs, leading to secondary metastasis.
Researchers do not know what causes cancer? but epidemiological studies suggested that genetic mutation inherited from the parent and acquired genetic alternation due to smoking, radiation, viruses, and carcinogens, are associated with the onset of the diseases.
Some researchers also strongly indicated that obesity-induced hormones change and, chronic inflammation is a major risk factors involved in the development of cancers in the Western world
Dr. Karen Basen-Engquis, the lead scientist in the cancer team wrote, "The prevalence of overweight and obesity is increasing worldwide, and the evidence base for a link between obesity and cancer is growing. In the United States, approximately 85,000 new cancer cases per year are related to obesity".
And, "Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%. Additionally, studies of patients who have had bariatric surgery for weight loss report reductions in cancer incidence and mortality, particularly for women".
These results clearly suggested reducing weight through diet and exercise or surgery may be the best way for attenuating the risk of cancer onset.
Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, It has been cultivated all over the world as hay for cattle feeding. The leaves, sprouts, and seeds have been used in traditional medicine for thousands of years to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance the digestive system, bleeding disorders, kidney, and urinary tract infections, etc.
North American Aboriginals have used Alfalfa seed as food, such as making bread and mush.
With an aim to find the natural ingredient or herbal remedy, researchers looked into L-Canavanine, a potentially toxic antimetabolite of L-arginine stored by sprouts, and in ten varieties of the seed of alfalfa, against a number of animal-bearing carcinomas and cancer cell lines.
The young plant exerted the strongest anti-cancer effects measured by the stored appreciable canavanine ranged from 1.3 to 2.4%, compared to that of 1.54 of the seed.
Alfalfa seed canavanine content levels were also found in the seeds of other members of the genus Canavalia, which are amongst the more abundant sources of this antimetabolite.
Dr, Watanabe K, and colleagues in the examining anti-colon cancer effect of dietary alfalfa, pectin, and wheat bran in female inbred F344 rats given at 7 weeks of age suggested, a dose of azoxymethane (AOM) of 8 mg/kg body weight/week for 10 weeks or methyl nitrosourea (MNU) intrarectally at a dose rate of 2 mg/rat twice a week for 3 weeks.
Examine the results from the autopsies at 40 weeks and the MNU-treated group 30 weeks after the first injection of the carcinogen, showed no tumors in the colon or other organs of untreated rats fed the various diets.
The animals fed the alfalfa diet and treated with MNU had a higher incidence of colon tumors than did those fed the control diet or the diets containing pectin or wheat bran.
The incidence of MNU-induced colon tumors did not differ between the animals fed the control diet or the diets containing pectin or wheat bran.
The incidence of AOM-induced colon tumors in rats fed diets containing pectin or wheat bran was lower than that in rats fed the control diet or the alfalfa diet.
These results clearly suggested that the effect of fiber in colon carcinogenesis depends on the type of fiber and, possibly, the fiber's mode of action.
Taken altogether, the conflict results indicated that further studies are necessary before herbal Alfalfa can be used for the prevention and combined with other therapy for the treatment of cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The natural abundance of L-canavanine, an active anticancer agent, in alfalfa, medicago sativa (L.). by Rosenthal GA, Nkomo P.(PubMed)
(2) Effect of dietary alfalfa, pectin, and wheat bran on azoxymethane-or methylnitrosourea-induced colon carcinogenesis in F344 rats. by Watanabe K, Reddy BS, Weisburger JH, Kritchevsky D.(PubMed)
(3) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist
and Maria Chang. (PMC)
Scientists do not agree that herbal Alfalfa can be used alone or combined with other primary medicine for the treatment of cancer, according to a study.
Cancer is a class of diseases characterized by cell growth irregularly and disorderly in the body tissue.
Most cases of cancer start in the cell on the surface of the inner lining of the tissue of the organ. In the early stage, due to the small size of the tumor, most patients do not experience any symptoms.
However, in the advanced stage, most cancer can cause bleeding and serious pain if the large size has pressed on the blood vessels and nearby nerve cells. In this stage, cancerous cells may travel a distance away from the original site to infect other tissue and organs, leading to secondary metastasis.
Researchers do not know what causes cancer? but epidemiological studies suggested that genetic mutation inherited from the parent and acquired genetic alternation due to smoking, radiation, viruses, and carcinogens, are associated with the onset of the diseases.
Some researchers also strongly indicated that obesity-induced hormones change and, chronic inflammation is a major risk factors involved in the development of cancers in the Western world
Dr. Karen Basen-Engquis, the lead scientist in the cancer team wrote, "The prevalence of overweight and obesity is increasing worldwide, and the evidence base for a link between obesity and cancer is growing. In the United States, approximately 85,000 new cancer cases per year are related to obesity".
And, "Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%. Additionally, studies of patients who have had bariatric surgery for weight loss report reductions in cancer incidence and mortality, particularly for women".
These results clearly suggested reducing weight through diet and exercise or surgery may be the best way for attenuating the risk of cancer onset.
Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, It has been cultivated all over the world as hay for cattle feeding. The leaves, sprouts, and seeds have been used in traditional medicine for thousands of years to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance the digestive system, bleeding disorders, kidney, and urinary tract infections, etc.
North American Aboriginals have used Alfalfa seed as food, such as making bread and mush.
With an aim to find the natural ingredient or herbal remedy, researchers looked into L-Canavanine, a potentially toxic antimetabolite of L-arginine stored by sprouts, and in ten varieties of the seed of alfalfa, against a number of animal-bearing carcinomas and cancer cell lines.
The young plant exerted the strongest anti-cancer effects measured by the stored appreciable canavanine ranged from 1.3 to 2.4%, compared to that of 1.54 of the seed.
Alfalfa seed canavanine content levels were also found in the seeds of other members of the genus Canavalia, which are amongst the more abundant sources of this antimetabolite.
Dr, Watanabe K, and colleagues in the examining anti-colon cancer effect of dietary alfalfa, pectin, and wheat bran in female inbred F344 rats given at 7 weeks of age suggested, a dose of azoxymethane (AOM) of 8 mg/kg body weight/week for 10 weeks or methyl nitrosourea (MNU) intrarectally at a dose rate of 2 mg/rat twice a week for 3 weeks.
Examine the results from the autopsies at 40 weeks and the MNU-treated group 30 weeks after the first injection of the carcinogen, showed no tumors in the colon or other organs of untreated rats fed the various diets.
The animals fed the alfalfa diet and treated with MNU had a higher incidence of colon tumors than did those fed the control diet or the diets containing pectin or wheat bran.
The incidence of MNU-induced colon tumors did not differ between the animals fed the control diet or the diets containing pectin or wheat bran.
The incidence of AOM-induced colon tumors in rats fed diets containing pectin or wheat bran was lower than that in rats fed the control diet or the alfalfa diet.
These results clearly suggested that the effect of fiber in colon carcinogenesis depends on the type of fiber and, possibly, the fiber's mode of action.
Taken altogether, the conflict results indicated that further studies are necessary before herbal Alfalfa can be used for the prevention and combined with other therapy for the treatment of cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The natural abundance of L-canavanine, an active anticancer agent, in alfalfa, medicago sativa (L.). by Rosenthal GA, Nkomo P.(PubMed)
(2) Effect of dietary alfalfa, pectin, and wheat bran on azoxymethane-or methylnitrosourea-induced colon carcinogenesis in F344 rats. by Watanabe K, Reddy BS, Weisburger JH, Kritchevsky D.(PubMed)
(3) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist
and Maria Chang. (PMC)
#Herbal #Bilberry Balances the Gut Microbiota in the Promotion of #DigestiveHealth, Studies Show
By Kyle J. Norton
Scientists may have found a natural and herbal remedy for the improvement of digestive gut microbiota for health optimization, according to studies.
Gut microbiota or gastrointestinal microbiota, the complex community of microorganisms in our digestive tracts play a critical role in a variety of metabolic functions, including producing vitamins, synthesizing all essential and nonessential amino acids, and carrying out biotransformation of bile.
Gut microbiota protects the intestinal structures and functions by attaching to the gut wall against the entry of pathogenic, enteroinvasive bacteria into the epithelial cells.
From the immune perspective, gut microbiota protects the intestines by alerting the immune response against foreign invasion through specific receptors, leading to an immune system inducing the proinflammatory cytokines.
However, the imbalance of digestive gut microbiota has been found to induce a number of diseases, syndromes, and functional aberrations, including inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), and wider systemic manifestations of diseases such as obesity, and type 2 diabetes.
Imbalanced gut microbiota is found in obese patients, compared to healthy-weight individuals.
Dr. Kyle J. Wolf, the lead scientist in the investigation of the link between obesity and gut microbiota, wrote, "
In recent years it has been definitively shown that microbiota in the gastrointestinal tract is altered in obese individuals".
And, "Normal humans and mice have 60% to 80% Firmicutes (which are primarily nonculturable, butyrate-producing Clostridium cluster XIVa) and 20% Bacteroidetes (Cytophaga-Flavobacterium-Bacteroides). However, the obese mouse model (ob/ob) had a 50% reduction in Bacteroidetes and an increase in Firmicutes. A similar decrease in Bacteroidetes and increase in Firmicutes is also seen when C57BL/6 mice are fed a high-fat (HF) diet".
The results in the mice model study strongly linked the Western diet and the risk of imbalanced gut microbiota in facilitating the onset of obesity.
Bilberry is a species of low-growing shrub in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
Scientists on finding a natural ingredient for the improvement of digestive system functioning in the elderly examined bilberry anthocyanin extract consumption and healthy aging and the effects on intestinal barrier function and digestive enzyme activity.
In the aging rats selected for the study, injection of medium-dose bilberry anthocyanin at 20 mg per kg bw per day) showed to optimize intestinal function.
Analyzing the gut microbiota, consumption of bilberry anthocyanin balanced the levels of bacteria in the intestine by increasing the good bacteria such as Aspergillus oryzae, Lactobacillus, Bacteroides, Clostridiaceae-1, the Bacteroidales-S24-7- and the Lachnospiraceae_NK4A136_group) and decreasing the levels of harmful bacterias, such as Verrucomicrobia and Euryarchaeota.
However. injection of any dose higher than 20 mg per kg displayed the alternation of some intestinally beneficial bacteria in an adverse way.
Furthermore, besides improving the levels of gut microbiota, consumption of bilberry anthocyanin also induced changes in short-chain fatty acids and the intestinal mucosal barrier, correlatedly.
In other words, the injection of the extract consumption also improved the decreased activity of digestive enzymes in breaking down the proteins into amino acids due to aging.
Dr. Li J, the lead scientist wrote, "Bilberry anthocyanin extract consumption is a potential approach for assisting healthy aging".
Moreover, in order to reveal more information about bilberry gut microbiota effects, researchers compared bilberries and cloudberries, the 2 berries on the. intestinal immune responses and gut microbiota.
Injection of bilberry not only reduced the expression of pro-inflammatory cytokines through immunomodulatory activity but also improved the balance of the gut microbiota compared to the cloudberries and control group.
Interestingly, cloudberry inhibited and bilberry exhibited the expression of energy metabolism-related genes in the intestinal mucosa.
Additionally, the microbial profiles of cloudberry-fed mice clustered together and associated with small adenoma size compared to the bilberry group.
The findings suggested that bilberry consumption demonstrated potential digestive health by attenuating of intestinal inflammation, improving microbial profiles, and exhibiting mucosal energy metabolism.
Taken altogether, bilberry processed with a high amount of bioactive compounds may be considered a functional remedy for optimizing bodily health by balancing the levels of gut microbiota.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry anthocyanin extract promotes intestinal barrier function and inhibits digestive enzyme activity by regulating the gut microbiota in aging rats by Li J1, Wu T1, Li N1, Wang X1, Chen G1, Lyu X. (PubMed)
(2) Changes in intestinal immunity, gut microbiota, and expression of energy metabolism-related genes explain adenoma growth in bilberry and cloudberry-fed ApcMin mice by Päivärinta E1, Niku M2, Maukonen J3, Storvik M4, Heiman-Lindh A5, Saarela M6, Pajari AM7, Mutanen M. (PubMed)
(3) Part 1: The Human Gut Microbiome in Health and Disease by Matthew J. Bull, BSc, Ph.D. and Nigel T. Plummer, Ph.D. (PMC)
(4) Gut Microbiota and Obesity by Kyle J. Wolfa and Robin G. Lorenz. (PMC)
Scientists may have found a natural and herbal remedy for the improvement of digestive gut microbiota for health optimization, according to studies.
Gut microbiota or gastrointestinal microbiota, the complex community of microorganisms in our digestive tracts play a critical role in a variety of metabolic functions, including producing vitamins, synthesizing all essential and nonessential amino acids, and carrying out biotransformation of bile.
Gut microbiota protects the intestinal structures and functions by attaching to the gut wall against the entry of pathogenic, enteroinvasive bacteria into the epithelial cells.
From the immune perspective, gut microbiota protects the intestines by alerting the immune response against foreign invasion through specific receptors, leading to an immune system inducing the proinflammatory cytokines.
However, the imbalance of digestive gut microbiota has been found to induce a number of diseases, syndromes, and functional aberrations, including inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), and wider systemic manifestations of diseases such as obesity, and type 2 diabetes.
Imbalanced gut microbiota is found in obese patients, compared to healthy-weight individuals.
Dr. Kyle J. Wolf, the lead scientist in the investigation of the link between obesity and gut microbiota, wrote, "
In recent years it has been definitively shown that microbiota in the gastrointestinal tract is altered in obese individuals".
And, "Normal humans and mice have 60% to 80% Firmicutes (which are primarily nonculturable, butyrate-producing Clostridium cluster XIVa) and 20% Bacteroidetes (Cytophaga-Flavobacterium-Bacteroides). However, the obese mouse model (ob/ob) had a 50% reduction in Bacteroidetes and an increase in Firmicutes. A similar decrease in Bacteroidetes and increase in Firmicutes is also seen when C57BL/6 mice are fed a high-fat (HF) diet".
The results in the mice model study strongly linked the Western diet and the risk of imbalanced gut microbiota in facilitating the onset of obesity.
Bilberry is a species of low-growing shrub in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herb in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, psoriasis, diabetes, etc.
Scientists on finding a natural ingredient for the improvement of digestive system functioning in the elderly examined bilberry anthocyanin extract consumption and healthy aging and the effects on intestinal barrier function and digestive enzyme activity.
In the aging rats selected for the study, injection of medium-dose bilberry anthocyanin at 20 mg per kg bw per day) showed to optimize intestinal function.
Analyzing the gut microbiota, consumption of bilberry anthocyanin balanced the levels of bacteria in the intestine by increasing the good bacteria such as Aspergillus oryzae, Lactobacillus, Bacteroides, Clostridiaceae-1, the Bacteroidales-S24-7- and the Lachnospiraceae_NK4A136_group) and decreasing the levels of harmful bacterias, such as Verrucomicrobia and Euryarchaeota.
However. injection of any dose higher than 20 mg per kg displayed the alternation of some intestinally beneficial bacteria in an adverse way.
Furthermore, besides improving the levels of gut microbiota, consumption of bilberry anthocyanin also induced changes in short-chain fatty acids and the intestinal mucosal barrier, correlatedly.
In other words, the injection of the extract consumption also improved the decreased activity of digestive enzymes in breaking down the proteins into amino acids due to aging.
Dr. Li J, the lead scientist wrote, "Bilberry anthocyanin extract consumption is a potential approach for assisting healthy aging".
Moreover, in order to reveal more information about bilberry gut microbiota effects, researchers compared bilberries and cloudberries, the 2 berries on the. intestinal immune responses and gut microbiota.
Injection of bilberry not only reduced the expression of pro-inflammatory cytokines through immunomodulatory activity but also improved the balance of the gut microbiota compared to the cloudberries and control group.
Interestingly, cloudberry inhibited and bilberry exhibited the expression of energy metabolism-related genes in the intestinal mucosa.
Additionally, the microbial profiles of cloudberry-fed mice clustered together and associated with small adenoma size compared to the bilberry group.
The findings suggested that bilberry consumption demonstrated potential digestive health by attenuating of intestinal inflammation, improving microbial profiles, and exhibiting mucosal energy metabolism.
Taken altogether, bilberry processed with a high amount of bioactive compounds may be considered a functional remedy for optimizing bodily health by balancing the levels of gut microbiota.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry anthocyanin extract promotes intestinal barrier function and inhibits digestive enzyme activity by regulating the gut microbiota in aging rats by Li J1, Wu T1, Li N1, Wang X1, Chen G1, Lyu X. (PubMed)
(2) Changes in intestinal immunity, gut microbiota, and expression of energy metabolism-related genes explain adenoma growth in bilberry and cloudberry-fed ApcMin mice by Päivärinta E1, Niku M2, Maukonen J3, Storvik M4, Heiman-Lindh A5, Saarela M6, Pajari AM7, Mutanen M. (PubMed)
(3) Part 1: The Human Gut Microbiome in Health and Disease by Matthew J. Bull, BSc, Ph.D. and Nigel T. Plummer, Ph.D. (PMC)
(4) Gut Microbiota and Obesity by Kyle J. Wolfa and Robin G. Lorenz. (PMC)
#Herbal #AniseExtracts and #EssentialOils in Reducing the Risk of #NonalcoholicFattyLiverDisease and #Cancer, Researchers Find
By Kyle J. Norton
Anise may have a potential and substantial effect in reduced risk and treatment of nonalcoholic fatty liver disease, some scientists suggested.
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic,...
Nonalcoholic fatty liver disease is a medical condition characterized by fat accumulated in the liver tissue other than excessive consumption of alcohol.
According to statistics, nonalcoholic fatty liver disease is one of the most common causes of liver disease with a prevalence rate of 20%–30% in the Western world.
In the comparison of the effect of anise fruit essential oil and extract and the risk of nonalcoholic fatty liver disease, researchers at the Islamic Azad University conducted an experiment of 60 rats randomly divided into ten groups, six in each group with NAFLD induced by using a choline-deficient diet for 90 days and followed by 30 days of treatment with 25, 50, 100, and 200 mg/kg/day of hydroethanolic extract (AE) as well as 0.125, 0.25, and 0.5 mg/kg/day of essential oil (AO) and found that both applications exerted a significantly reverse activity in increased AE and AO plasma levels of total cholesterol, low-density lipoprotein, and triacylglycerol and decrease in high-density lipoprotein level caused by choline-deficient diet in a dose-dependent manner.
Additional differentiation also found that AE and AO reduced the elevated levels of enzymes aspartate transaminase (AST) and alanine transaminase (ALT) which are considered as an indication of either liver injury or damage caused by the acute inflammation in the experiential subject model.
Observation of injection anise AE and AO also exerted a powerful antioxidant activity in significantly lower overexpression of ROS in an exhibited free radical chain reaction in the induction of oxidative stress to precipitated liver toxicity.
According to the histological findings, researchers concluded that both AE and AO display a substantial effect in reduced macrovesicular steatohepatitis which is the leading cause of liver cancer.
Further analysis also addressed that both anise AE and AO demonstrated a strong effect in ameliorated lipid peroxidation induced by oxidative stress indicated by elevation of plasma level of 8-isoprostane which is correlated to the prevalence of non-alcoholic fatty liver disease (NAFLD).
Elevated 8-Isoprostane values activated by lipid peroxidation induced by injection of a choline-deficient diet are also considered as a biomarker in patients with non-alcoholic liver disease and correlated with body mass index and with total cholesterol in NAFLD but did not significantly relate to sex, age, biochemical data or iron metabolism markers in all liver diseases.
Therefore, people with high body mass index and high levels of total cholesterol levels are susceptible to increase risk of diseases.
Taken together, herbal Anise with abundant bioactive chemical constituents and essential oil may be effective for reduced risk and treatment of nonalcoholic liver disease, but intake of herbal extract should only be prescribed by related field specialists in the prevention of toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Pimpinella anisum L. fruit: Chemical composition and effect on rat model of nonalcoholic fatty liver disease by Asadollahpoor A1, Abdollahi M2, Rahimi R3,(PubMed)
Anise may have a potential and substantial effect in reduced risk and treatment of nonalcoholic fatty liver disease, some scientists suggested.
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic,...
Nonalcoholic fatty liver disease is a medical condition characterized by fat accumulated in the liver tissue other than excessive consumption of alcohol.
According to statistics, nonalcoholic fatty liver disease is one of the most common causes of liver disease with a prevalence rate of 20%–30% in the Western world.
In the comparison of the effect of anise fruit essential oil and extract and the risk of nonalcoholic fatty liver disease, researchers at the Islamic Azad University conducted an experiment of 60 rats randomly divided into ten groups, six in each group with NAFLD induced by using a choline-deficient diet for 90 days and followed by 30 days of treatment with 25, 50, 100, and 200 mg/kg/day of hydroethanolic extract (AE) as well as 0.125, 0.25, and 0.5 mg/kg/day of essential oil (AO) and found that both applications exerted a significantly reverse activity in increased AE and AO plasma levels of total cholesterol, low-density lipoprotein, and triacylglycerol and decrease in high-density lipoprotein level caused by choline-deficient diet in a dose-dependent manner.
Additional differentiation also found that AE and AO reduced the elevated levels of enzymes aspartate transaminase (AST) and alanine transaminase (ALT) which are considered as an indication of either liver injury or damage caused by the acute inflammation in the experiential subject model.
Observation of injection anise AE and AO also exerted a powerful antioxidant activity in significantly lower overexpression of ROS in an exhibited free radical chain reaction in the induction of oxidative stress to precipitated liver toxicity.
According to the histological findings, researchers concluded that both AE and AO display a substantial effect in reduced macrovesicular steatohepatitis which is the leading cause of liver cancer.
Further analysis also addressed that both anise AE and AO demonstrated a strong effect in ameliorated lipid peroxidation induced by oxidative stress indicated by elevation of plasma level of 8-isoprostane which is correlated to the prevalence of non-alcoholic fatty liver disease (NAFLD).
Elevated 8-Isoprostane values activated by lipid peroxidation induced by injection of a choline-deficient diet are also considered as a biomarker in patients with non-alcoholic liver disease and correlated with body mass index and with total cholesterol in NAFLD but did not significantly relate to sex, age, biochemical data or iron metabolism markers in all liver diseases.
Therefore, people with high body mass index and high levels of total cholesterol levels are susceptible to increase risk of diseases.
Taken together, herbal Anise with abundant bioactive chemical constituents and essential oil may be effective for reduced risk and treatment of nonalcoholic liver disease, but intake of herbal extract should only be prescribed by related field specialists in the prevention of toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Pimpinella anisum L. fruit: Chemical composition and effect on rat model of nonalcoholic fatty liver disease by Asadollahpoor A1, Abdollahi M2, Rahimi R3,(PubMed)
#Herbal #Anise in Ameliorating the Menopausal Hot Flash Frequency and Severity in Clinical Trials
By Kyle J. Norton
Anise may have a potential and substantial effect in relief and reduced recurrence of menopausal hot flashes, some scientists suggested.
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....agent.
Hot flashes are the frequent symptoms of menopause induced sudden feelings of warmth in some parts of the body. The symptoms affect approximately 75% of all women in perimenopause in the Western world.
In the investigation of the effect of Pimpinella anisum and symptoms of a hot flash in postmenopausal women, researchers at the Shahid Beheshti Universit conducted a review of medical records at health centers of a sample of 72 women with hot flashes randomly selected according to the predetermined criteria and divided into experimental group received a capsule containing 330 mg Pimpinella anisum 3 times a day and control group received 3 capsules, each containing 330 mg potato starch, over 4 weeks with pre-treatment of frequency and severity of hot flashes taken in 2 weeks before administration indicated that women in anise treatment group exert a significantly reduced frequency and severity of hot flashes from the pre-treatment of 4.21% and 56.21% to 1.06% and 14.44% at the end of the fourth week respectively in compared to the control group.
Further analysis found that women who are in the anise testing group also continue to benefit from the amelioration of the frequency and severity of hot flashes in 4 weeks of follow-up examination.
These results suggested that long term intake of herbal Anise may have a continued efficacy in relief and recurrence of menopausal hot flashes.
Additional illustration of the prevalence of hot flash in menopause women by reviewing the literature published on MEDLINE (1966 to January 2015), Scopus (1996 to January 2015), and Cochrane Central Register of Controlled Trials (The Cochrane Library, issue 1, 2015), researchers at joint study lead by the Mashhad University of Medical Science showed that overall studies approved the herbal effects of Anise in contribution of reduced hot flash occurrence and frequency as well as alleviating the side effects of hot flashes.
Moreover, in the double-blind clinical trial conducted to determine the effects of Anise abstract on hot flashes in women referring to rural and urban health centers of Qazvin province during 2006 by randomly assigned 72 postmenopausal women at different verities selected according to pre-determined criteria and divided into a group of the experimental group took a capsule containing 100 mg Anise 3 times a day and control group received 3 placebo capsules, each containing 330 mg starch over 4 weeks experimental periods, searchers after compared to the frequency of hot flashes and the types of food they took 1 week before administrations found that there is a significant difference in hot flash expression in these 2 groups of women
The Anise group showed a substantial decrease in the frequency and severity of hot flashes from 4.21% and 56.21% before treatment and 1.06% and 14.44% at the end of the fourth week, respectively.
And women in control expressed an insignificant change in hot flash frequency and severity compared to measurement before treatment.
Interestingly, after taking account of other confounders, Dr. Fatemeh Nahidi, the lead author said, "Women can be taught to choose different alleviating methods, preferably".
In other words, by providing enough information, women who suffered from menopause hot flashes should be able to choose different alleviating methods for relief and recurrence of the symptoms.
Women who do not tolerate the side effect of conventional medicine with symptoms of the hot flash may want to add a portion of Anise into their diet, please consult with your herbalist before taking the herbs for preventive measures.
Due to the short term of 4 weeks of study, some researchers suggested that further studies with longer duration of treatment Anise for assessing hot flashes are necessary.
Taken together, herbal Anise may be considered an adjunct therapy used a combination with the standard treatment of hot flashes in women in peri-menopause, menopause, and post-menopause. However, intake of herbal Anise supplements should be taken with extreme care in prevented toxicity.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) The Study on the Effects of Pimpinella anisum on Relief and Recurrence of Menopausal Hot Flashes by Nahidi F1, Kariman N, Simbar M, Mojab F.(PubMed)
(2) The efficacy of Iranian herbal medicines in alleviating hot flashes: A systematic review by Ghazanfarpour M1, Sadeghi R2, Abdolahian S3, Latifnejad Roudsari R4.(PubMed)
(3) Effect of anise extract on hot flush of menopause by Fatemeh Nahidi, M. Taherpour, F. Mojab, Hamid Alavi Majd(Research Gate)
Anise may have a potential and substantial effect in relief and reduced recurrence of menopausal hot flashes, some scientists suggested.
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....agent.
Hot flashes are the frequent symptoms of menopause induced sudden feelings of warmth in some parts of the body. The symptoms affect approximately 75% of all women in perimenopause in the Western world.
In the investigation of the effect of Pimpinella anisum and symptoms of a hot flash in postmenopausal women, researchers at the Shahid Beheshti Universit conducted a review of medical records at health centers of a sample of 72 women with hot flashes randomly selected according to the predetermined criteria and divided into experimental group received a capsule containing 330 mg Pimpinella anisum 3 times a day and control group received 3 capsules, each containing 330 mg potato starch, over 4 weeks with pre-treatment of frequency and severity of hot flashes taken in 2 weeks before administration indicated that women in anise treatment group exert a significantly reduced frequency and severity of hot flashes from the pre-treatment of 4.21% and 56.21% to 1.06% and 14.44% at the end of the fourth week respectively in compared to the control group.
Further analysis found that women who are in the anise testing group also continue to benefit from the amelioration of the frequency and severity of hot flashes in 4 weeks of follow-up examination.
These results suggested that long term intake of herbal Anise may have a continued efficacy in relief and recurrence of menopausal hot flashes.
Additional illustration of the prevalence of hot flash in menopause women by reviewing the literature published on MEDLINE (1966 to January 2015), Scopus (1996 to January 2015), and Cochrane Central Register of Controlled Trials (The Cochrane Library, issue 1, 2015), researchers at joint study lead by the Mashhad University of Medical Science showed that overall studies approved the herbal effects of Anise in contribution of reduced hot flash occurrence and frequency as well as alleviating the side effects of hot flashes.
Moreover, in the double-blind clinical trial conducted to determine the effects of Anise abstract on hot flashes in women referring to rural and urban health centers of Qazvin province during 2006 by randomly assigned 72 postmenopausal women at different verities selected according to pre-determined criteria and divided into a group of the experimental group took a capsule containing 100 mg Anise 3 times a day and control group received 3 placebo capsules, each containing 330 mg starch over 4 weeks experimental periods, searchers after compared to the frequency of hot flashes and the types of food they took 1 week before administrations found that there is a significant difference in hot flash expression in these 2 groups of women
The Anise group showed a substantial decrease in the frequency and severity of hot flashes from 4.21% and 56.21% before treatment and 1.06% and 14.44% at the end of the fourth week, respectively.
And women in control expressed an insignificant change in hot flash frequency and severity compared to measurement before treatment.
Interestingly, after taking account of other confounders, Dr. Fatemeh Nahidi, the lead author said, "Women can be taught to choose different alleviating methods, preferably".
In other words, by providing enough information, women who suffered from menopause hot flashes should be able to choose different alleviating methods for relief and recurrence of the symptoms.
Women who do not tolerate the side effect of conventional medicine with symptoms of the hot flash may want to add a portion of Anise into their diet, please consult with your herbalist before taking the herbs for preventive measures.
Due to the short term of 4 weeks of study, some researchers suggested that further studies with longer duration of treatment Anise for assessing hot flashes are necessary.
Taken together, herbal Anise may be considered an adjunct therapy used a combination with the standard treatment of hot flashes in women in peri-menopause, menopause, and post-menopause. However, intake of herbal Anise supplements should be taken with extreme care in prevented toxicity.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA FOR WOMEN
Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) The Study on the Effects of Pimpinella anisum on Relief and Recurrence of Menopausal Hot Flashes by Nahidi F1, Kariman N, Simbar M, Mojab F.(PubMed)
(2) The efficacy of Iranian herbal medicines in alleviating hot flashes: A systematic review by Ghazanfarpour M1, Sadeghi R2, Abdolahian S3, Latifnejad Roudsari R4.(PubMed)
(3) Effect of anise extract on hot flush of menopause by Fatemeh Nahidi, M. Taherpour, F. Mojab, Hamid Alavi Majd(Research Gate)
#Healthyfood #Cranberry Inhibits #ProInflammatoryCytokines Against the of #Colitis, Researchers Say
By Kyle J. Norton
Colitis is a medical condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.
Most cases of colitis are caused by infection, such as bacteria like C. difficile, viruses, and parasites, and inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis (UC).
However, according to a study by the Catholic University of the Sacred Heart, depending on the causes, colitis can be classified into microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, Behcet's colitis.
The most common symptoms of colitis are abdominal pain and diarrhea, bleeding per rectum, distention with bloody diarrhea, abdominal bloating, and flatulence, and changes in bowel habits.
In severe cases, patients may also experience symptoms of elevated liver enzymes, leukopenia, thrombocytopenia, severe peripheral arthralgias, and chronic watery diarrhea.
Believe it or not, fifty-five percent of patients stated that UC symptoms over the past year had affected their quality of life, while physicians and nurses estimated that 35% to 37% of patients would have a reduced quality of life.
Conventionally, treatments of colitis are total depending on the type and severity of the condition. For example, in patients with inflammatory bowel disease (IBD), Self-care at home through home tele-management, Web-guided therapy, and pain management are the most common approach accompanied by biological therapy, if necessary.
Some researchers suggested the promotion of the Western diet over the past few decades may be the leading cause of colitis in patients with IBD.
Dr. Jimmy K. Limdi wrote, "The parallelism between “westernization” and particularly high dietary intakes of total fat (particularly animal fats, ω-6 polyunsaturated fatty acids (PUFA), milk fats), refined sugars, meat and lower intakes of fruit and vegetables, implicates diet in the great risk of developing IBD".
And, "Diet may influence intestinal inflammation through several biologically plausible mechanisms including dietary antigen presentation, alterations in the gut microbiome, the mucosal immune system and epithelial barrier function among others".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry is cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine for the treatment of wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of IBD, researchers examined the effects of cranberry products on preventing dextran sulfate sodium-induced murine colitis.
According to the tested differentiation, both cranberry extract and dried cranberries-fed groups had significant activity against the disease index.
However, dried cranberries were more effective in preventing colitis compared to that cranberry extract.
Moreover, both cranberry applications also showed a significant effect in preventing the shortening of colon length,
Biomarkers associated with inflammatory bowel diseases (IBD) such as colonic myeloperoxidase activity were attenuated in animals fed dried cranberries compared to the controls.
Additionally, dried cranberries also inhibited much better results against the production of pro-inflammatory cytokines caused by the injection of dextran sulfate sodium, compared to the controls.
Based on the findings, researchers wrote, "The current report suggests that cranberries can be applied to prevent and reduce the symptoms of IBD".
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of colitis in IBD patients, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Diets enriched with cranberry beans alter the microbiota and mitigate colitis severity and associated inflammation by Monk JM1, Lepp D2, Zhang CP1, Wu W2, Zarepoor L1, Lu JT1, Pauls KP3, Tsao R2, Wood GA4, Robinson LE5, Power KA. (PubMed)
(2) Preventive effects of cranberry products on experimental colitis induced by dextran sulfate sodium in mice by Xiao X1, Kim J1, Sun Q1, Kim D2, Park CS3, Lu TS4, Park Y. (PubMed)
(3) Colitides by Tortora A1, Purchiaroni F, Scarpellini E, Ojetti V, Gabrielli M, Vitale G, Giovanni G, Gasbarrini A. (PubMed)
(4) Dietary Practices and inflammatory bowel disease by Jimmy K. Limdi. (PMC)
Colitis is a medical condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.
Most cases of colitis are caused by infection, such as bacteria like C. difficile, viruses, and parasites, and inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis (UC).
However, according to a study by the Catholic University of the Sacred Heart, depending on the causes, colitis can be classified into microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, Behcet's colitis.
The most common symptoms of colitis are abdominal pain and diarrhea, bleeding per rectum, distention with bloody diarrhea, abdominal bloating, and flatulence, and changes in bowel habits.
In severe cases, patients may also experience symptoms of elevated liver enzymes, leukopenia, thrombocytopenia, severe peripheral arthralgias, and chronic watery diarrhea.
Believe it or not, fifty-five percent of patients stated that UC symptoms over the past year had affected their quality of life, while physicians and nurses estimated that 35% to 37% of patients would have a reduced quality of life.
Conventionally, treatments of colitis are total depending on the type and severity of the condition. For example, in patients with inflammatory bowel disease (IBD), Self-care at home through home tele-management, Web-guided therapy, and pain management are the most common approach accompanied by biological therapy, if necessary.
Some researchers suggested the promotion of the Western diet over the past few decades may be the leading cause of colitis in patients with IBD.
Dr. Jimmy K. Limdi wrote, "The parallelism between “westernization” and particularly high dietary intakes of total fat (particularly animal fats, ω-6 polyunsaturated fatty acids (PUFA), milk fats), refined sugars, meat and lower intakes of fruit and vegetables, implicates diet in the great risk of developing IBD".
And, "Diet may influence intestinal inflammation through several biologically plausible mechanisms including dietary antigen presentation, alterations in the gut microbiome, the mucosal immune system and epithelial barrier function among others".
Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry is cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine for the treatment of wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.
In finding a potential compound for the treatment of IBD, researchers examined the effects of cranberry products on preventing dextran sulfate sodium-induced murine colitis.
According to the tested differentiation, both cranberry extract and dried cranberries-fed groups had significant activity against the disease index.
However, dried cranberries were more effective in preventing colitis compared to that cranberry extract.
Moreover, both cranberry applications also showed a significant effect in preventing the shortening of colon length,
Biomarkers associated with inflammatory bowel diseases (IBD) such as colonic myeloperoxidase activity were attenuated in animals fed dried cranberries compared to the controls.
Additionally, dried cranberries also inhibited much better results against the production of pro-inflammatory cytokines caused by the injection of dextran sulfate sodium, compared to the controls.
Based on the findings, researchers wrote, "The current report suggests that cranberries can be applied to prevent and reduce the symptoms of IBD".
Taken altogether, cranberry may be considered a remedy for the prevention and treatment of colitis in IBD patients, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Diets enriched with cranberry beans alter the microbiota and mitigate colitis severity and associated inflammation by Monk JM1, Lepp D2, Zhang CP1, Wu W2, Zarepoor L1, Lu JT1, Pauls KP3, Tsao R2, Wood GA4, Robinson LE5, Power KA. (PubMed)
(2) Preventive effects of cranberry products on experimental colitis induced by dextran sulfate sodium in mice by Xiao X1, Kim J1, Sun Q1, Kim D2, Park CS3, Lu TS4, Park Y. (PubMed)
(3) Colitides by Tortora A1, Purchiaroni F, Scarpellini E, Ojetti V, Gabrielli M, Vitale G, Giovanni G, Gasbarrini A. (PubMed)
(4) Dietary Practices and inflammatory bowel disease by Jimmy K. Limdi. (PMC)
#Herbal #Ashwagandha Improves the Quality of Life and Survival Rate of #BreastCancer Patients, According to Clinical Trials
By Kyle J. Norton
The breast formed part of the reproductive system consists of tissue overlying the chest (pectoral) muscles. In women, the breasts are made of produces milk (glandular tissue) and fatty tissue.
The size of the women's breast is totally depending on the amount of breast fatty tissue.
Depending on the menstrual stage induced by hormone expression, the breast ducts transport milk from the lobules out to the nipple.
In pregnancy, the changes to the breasts can start as early as 1 to 2 weeks after conception, leading to swelling or tenderness.
Breast cancer is a medical condition caused by the alternation of DNA of cells in the breast tissue.
According to the statistic, in 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Most cases of breast cancer start with cell growth disorderly on the surface of the inner lining of the breast tissue. At the later stage, malignant cells can infected other healthy cells and tissue far the way from the breast through fluids and blood circulation.
The exact causes of breast cancer are unknown. However, aging, reproductive history, dense breast, family and personal breast cancer history, particularly in women with the genetic preposition of BRCA 1 and 2 are some of the most prevalent factors associated with the disease.
Women who inherited the mutated gene BRCA 1 and 2 are associated with over 60% of breast cancer risk compared to women who do not.
Some researchers suggested the promotion of a high-fat diet induced overweight and obesity over the past few decades may correlate to the increased incidence and motility of breast cancer in the US.
Dr. Carroll KK wrote, "High-fat diets are thought to increase the risk of breast cancer because animals develop mammary cancer more readily when they are fed high-fat compared to low-fat diets, and breast cancer incidence and mortality are higher in countries with high-fat as compared to those with low-fat diets".
And, "Studies on migrants have shown that breast cancer incidence and mortality increase in populations who move from countries with low-fat to those with high-fat diets, indicating that observed geographical differences in breast cancer are due to environmental rather than genetic factors".
These results strongly suggested a long-term high-fat diet is associated with an increased risk of breast cancer.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
With an aim to find a potent compound for the treatment of symptoms associated the chemotherapy in breast cancer patients, researchers examined the Withania somnifera (Ashwagandha) anti-side effects of chemo drug.
The open-label prospective nonrandomized comparative trial included a total of 100 patients with breast cancer in all stages undergoing either a combination of chemotherapy with oral Withania somnifera at a dose of 2 g every 8 hours or chemotherapy alone.
Withania somnifera root extract was administered to patients in the study group throughout the course of chemotherapy.
According to the results, patients in the control arm or chemotherapy-only treatment group experienced a statistically significant higher estimated marginal means of fatigue score compared to the study group.
Statistically, 7 out of 18 symptoms in the intervention group were significantly elevated in the control compared with the control group, according to the various symptom scales of the EORTC QLQ-C30.
More importantly, the 24-month overall survival for all stages in the study group was significantly higher at 72% compared to 56% of the control.
However, a median follow-up duration of 26 months.was not different in both groups. In other words, continued Withania somnifera root extract treatment may increase the survival rate of breast cancer patients in all stages.
Based on the findings, researchers said, "Withania somnifera has potential against cancer-related fatigue, in addition to improving the quality of life".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for reduction of chemo drugs side effects in breast cancer patients, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients by Biswal BM1, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. (PubMed)
(2) An anti-cancerous protein fraction from Withania somnifera induces ROS-dependent mitochondria-mediated apoptosis in human MDA-MB-231 breast cancer cells by Dar PA1, Mir SA2, Bhat JA2, Hamid A3, Singh LR4, Malik F5, Dar TA. (PubMed)
(3) Dietary fat and breast cancer by Carroll KK. (PubMed)
The breast formed part of the reproductive system consists of tissue overlying the chest (pectoral) muscles. In women, the breasts are made of produces milk (glandular tissue) and fatty tissue.
The size of the women's breast is totally depending on the amount of breast fatty tissue.
Depending on the menstrual stage induced by hormone expression, the breast ducts transport milk from the lobules out to the nipple.
In pregnancy, the changes to the breasts can start as early as 1 to 2 weeks after conception, leading to swelling or tenderness.
Breast cancer is a medical condition caused by the alternation of DNA of cells in the breast tissue.
According to the statistic, in 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Most cases of breast cancer start with cell growth disorderly on the surface of the inner lining of the breast tissue. At the later stage, malignant cells can infected other healthy cells and tissue far the way from the breast through fluids and blood circulation.
The exact causes of breast cancer are unknown. However, aging, reproductive history, dense breast, family and personal breast cancer history, particularly in women with the genetic preposition of BRCA 1 and 2 are some of the most prevalent factors associated with the disease.
Women who inherited the mutated gene BRCA 1 and 2 are associated with over 60% of breast cancer risk compared to women who do not.
Some researchers suggested the promotion of a high-fat diet induced overweight and obesity over the past few decades may correlate to the increased incidence and motility of breast cancer in the US.
Dr. Carroll KK wrote, "High-fat diets are thought to increase the risk of breast cancer because animals develop mammary cancer more readily when they are fed high-fat compared to low-fat diets, and breast cancer incidence and mortality are higher in countries with high-fat as compared to those with low-fat diets".
And, "Studies on migrants have shown that breast cancer incidence and mortality increase in populations who move from countries with low-fat to those with high-fat diets, indicating that observed geographical differences in breast cancer are due to environmental rather than genetic factors".
These results strongly suggested a long-term high-fat diet is associated with an increased risk of breast cancer.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
With an aim to find a potent compound for the treatment of symptoms associated the chemotherapy in breast cancer patients, researchers examined the Withania somnifera (Ashwagandha) anti-side effects of chemo drug.
The open-label prospective nonrandomized comparative trial included a total of 100 patients with breast cancer in all stages undergoing either a combination of chemotherapy with oral Withania somnifera at a dose of 2 g every 8 hours or chemotherapy alone.
Withania somnifera root extract was administered to patients in the study group throughout the course of chemotherapy.
According to the results, patients in the control arm or chemotherapy-only treatment group experienced a statistically significant higher estimated marginal means of fatigue score compared to the study group.
Statistically, 7 out of 18 symptoms in the intervention group were significantly elevated in the control compared with the control group, according to the various symptom scales of the EORTC QLQ-C30.
More importantly, the 24-month overall survival for all stages in the study group was significantly higher at 72% compared to 56% of the control.
However, a median follow-up duration of 26 months.was not different in both groups. In other words, continued Withania somnifera root extract treatment may increase the survival rate of breast cancer patients in all stages.
Based on the findings, researchers said, "Withania somnifera has potential against cancer-related fatigue, in addition to improving the quality of life".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for reduction of chemo drugs side effects in breast cancer patients, pending to the result of larger sample size and multicenter study
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients by Biswal BM1, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. (PubMed)
(2) An anti-cancerous protein fraction from Withania somnifera induces ROS-dependent mitochondria-mediated apoptosis in human MDA-MB-231 breast cancer cells by Dar PA1, Mir SA2, Bhat JA2, Hamid A3, Singh LR4, Malik F5, Dar TA. (PubMed)
(3) Dietary fat and breast cancer by Carroll KK. (PubMed)
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