By Kyle J. Norton
Antioxidants are stable molecules produced by the liver or from the intake of diet sources, including foods and supplementation.
The function of antioxidants is to protect the body against oxidation induced by free radicals.
Free radicals are a normal byproduct of oxygen metabolism. Certain environmental and behavioral factors such as exposure to radiation and toxic chemicals and smoking can dramatically increase the number of free radicals in the body.
Free radicals have an unpaired electron on the outer ring. Therefore, in order to maintain stability, free radicals must donate or intercept an electron from other atoms, causing a domino reaction that can not be stopped until all single electrons are paired or inhibited by antioxidants.
Oxidative stress is a result of the imbalanced ratio of the levels of free radicals compared to antioxidants.
In other words, if the antioxidant enzymes no longer can perform the function to balance the free radicals in the body, oxidative stress occurs.
Epidemiologically, oxidative stress has been found to cause protein, lipid, and alternation of cellular DNA, leading to the incidence of chronic illness and cancers.
Dr. V. Hajhashemi, the lead scientist in the elevation of the effects of antioxidants for disease prevention wrote, "Free radicals are produced continuously in the cells as part of normal cellular function, however, excess production might play a role in pathophysiology of many disease conditions, including cancer, Alzheimer's disease, atherosclerosis and some of the drug-induced toxicity".
And, " Many basic research studies and observational epidemiologic studies in human suggest that antioxidants can prevent oxidative damage".
In other words, by maintaining the healthy ratio of antioxidants and free radicals, diseases associated with oxidative stress can be preventable.
Some researchers suggested, maintaining a balanced ratio of free radicals and antioxidants are the best way for good health.
Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a potential compound for the treatment of oxidative stress, researchers examined the on betacyanins phenol antioxidants activity against peroxyl radicals generated from the azo-initiated oxidation of methyl linoleate in methanol and of a heterogeneous aqueous/soybean phosphatidylcholine liposomal system
In major compound betanin, researchers found that the phytochemical, a weak retarder in methanol is an effective chain-breaking antioxidant in the liposomal model.
In other words, kinetic solvent activity and partition in lipid bilayers may affect betanin antioxidant properties.
In betanidin, another bioactive compound shows a significant effect on chain-terminating antioxidants in both models.
In ROS activity, betanidin demonstrated a stronger radical-scavenging activity compared to betanin, in terms of both radical-scavenging rates constant and stoichiometric factor.
The results suggest that betacyanins exert significant anti-ROS expression by blocking the initiation and progression and induce-termination of a free radical chain reaction through the bioactive compound betanin and betanidin.
Based on the finding, researchers said, " Either betanin or betanidin incorporated in liposomes with alpha-tocopherol had additive effects, supporting the partition of the pigments in the bilayer and lipo peroxyl radical reduction".
Taken altogether, betacyanins may be considered a remedy for the prevention and treatment of diseases associated with oxidative stress, pending the confirmation of the larger sample size and multicenter human study.
Intake of betacyanins in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoperoxyl radical-scavenging activity in solution and liposomes by Tesoriere L1, Allegra M, Gentile C, Livrea MA. (PubMed)
(2) Effect of solvent type and ratio on betacyanins and antioxidant activity of extracts from Hylocereus polyrhizus flesh and peel by supercritical fluid extraction and solvent extraction by Fathordoobady F1, Mirhosseini H1, Selamat J2, Manap MY. (PubMed)
(3) Are antioxidants helpful for disease prevention? by V. Hajhashemi,1,* G. Vaseghi,1 M. Pourfarzam,2 and A. Abdollahi. (PMC)
Wednesday, 7 June 2023
#Healthyfood #Ginger Exhibits #Painkiller Activities through #Antiinflammation and #Analgesic Effects, According to Studies
By Kyle J.Norton
Ginger is one of the natural whole food recommended by many scientists for the treatment of muscle pain and soreness.
Muscle pain is a common condition that can arise from a number of factors including injury or overexertion, infections of soft tissues, or inflammation.
Another factor such as the flu may also cause muscle pain.
Medication used for the treatment of cholesterol such as statins, fibromyalgia, and underactive thyroidism is also associated with the onset of muscle pain.
Swelling, redness, or fever are also the most common symptoms accompanied by muscle pain.
Acute pain triggered by the nervous system alerts you to possible injury.
Chronic muscle pain is pain that lasts more than 3 months. Most cases of chronic muscle are caused by a syndrome of chronic myofascial pain (CMP), a painful condition that affects the muscles and the sheath of the tissue that surrounds the muscles.
The syndrome processes the most highly sensitive and notable symptom associated with the areas within the muscles that can also stimulate the pain in the other area of the body.
In contrast to chronic myofascial pain (CMP), fibromyalgia syndrome (FMS) also cause chronic muscle pain due to brain disorder in processing pain signalings
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In the reaffirming ginger root pain-relief properties, researchers at Old Dominion University launched a randomized, double-blind, placebo-controlled trial to determine whether ginger root supplementation reduces muscle soreness and dysfunction from downhill running.
Thirty-two runners (10 women, 22 men) included in the trial were pair-matched and randomized to 1.425 g/day of ginger root or placebo for 5 days.
Ang a 40-minute downhill (-7.5%) run was completed on day 3. Before supplementation and at various points throughout a 5-day protocol, muscle soreness, pain-pressure threshold, vertical jump, and 1.5-mile run performance.
Soreness while jogging likely increased to a lesser degree with ginger root from baseline. Ginger root had a possible small benefit on the vertical jump from baseline to day 5 but no meaningful impact on the 1.5-mile run performance.
No significant differences in adverse events were observed during the experiment between treatments.
The results suggested that ginger root possibly has moderate beneficial effects on running-induced soreness but irrelevant effects on recovery of physical performance.
Dr. Wilson PB, said, "Ginger represents one option for runners looking to temporarily reduce pain".
Furthermore, in the findings, a natural ingredient for the treatment of inflammation and pain induced by delayed onset muscle soreness (DOMS), a joint study led by Shiraz University, was launched to examine the effect of ginger extract on the biochemical and functional symptom of delayed onset muscle soreness.
36 healthy female subjects included in the study were recruited by intra-dormitory calls and randomly divided into 3 groups, including ginger intake 1 hour before exercise (GIBE), ginger intake immediately after exercise (GIAE), and placebo group (PL).
Participants consumed capsules containing 60 mg of ginger extract (the equivalent of 2 g dried ginger powder) or a placebo before and after exercise. The exercise protocol consisted of a 20-minute step test using a 46cm step at a rate of 15 steps per minute.
Ginger intake immediately after exercise (GIAE) showed a significant reduction of pain compared to GIAE after 24 and 48h of EE and GIAE compared to PL.
The inflammatory cytokine IL-6 changed significantly in GIBE compared to PL (p<0.05) after 1, 24, and 48h after EE.
These results indicated that 2 grams of ginger may have anti-inflammation and analgesic effects on DOMS.
Taken altogether, ginger root may be considered a functional painkiller kitchen spice for the deduction of muscle pain and soreness if it is intake 1 hour before exercise.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) A Randomized Double-Blind Trial of Ginger Root for Reducing Muscle Soreness and Improving Physical Performance Recovery Among Experienced Recreational Distance Runners.
Wilson PB. (PubMed)
(2) Acute effects of ginger extract on biochemical and functional symptoms of delayed onset muscle soreness by Hoseinzadeh K1, Daryanoosh F2, Baghdasar PJ3, Alizadeh H. (PubMed)
Ginger is one of the natural whole food recommended by many scientists for the treatment of muscle pain and soreness.
Muscle pain is a common condition that can arise from a number of factors including injury or overexertion, infections of soft tissues, or inflammation.
Another factor such as the flu may also cause muscle pain.
Medication used for the treatment of cholesterol such as statins, fibromyalgia, and underactive thyroidism is also associated with the onset of muscle pain.
Swelling, redness, or fever are also the most common symptoms accompanied by muscle pain.
Acute pain triggered by the nervous system alerts you to possible injury.
Chronic muscle pain is pain that lasts more than 3 months. Most cases of chronic muscle are caused by a syndrome of chronic myofascial pain (CMP), a painful condition that affects the muscles and the sheath of the tissue that surrounds the muscles.
The syndrome processes the most highly sensitive and notable symptom associated with the areas within the muscles that can also stimulate the pain in the other area of the body.
In contrast to chronic myofascial pain (CMP), fibromyalgia syndrome (FMS) also cause chronic muscle pain due to brain disorder in processing pain signalings
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In the reaffirming ginger root pain-relief properties, researchers at Old Dominion University launched a randomized, double-blind, placebo-controlled trial to determine whether ginger root supplementation reduces muscle soreness and dysfunction from downhill running.
Thirty-two runners (10 women, 22 men) included in the trial were pair-matched and randomized to 1.425 g/day of ginger root or placebo for 5 days.
Ang a 40-minute downhill (-7.5%) run was completed on day 3. Before supplementation and at various points throughout a 5-day protocol, muscle soreness, pain-pressure threshold, vertical jump, and 1.5-mile run performance.
Soreness while jogging likely increased to a lesser degree with ginger root from baseline. Ginger root had a possible small benefit on the vertical jump from baseline to day 5 but no meaningful impact on the 1.5-mile run performance.
No significant differences in adverse events were observed during the experiment between treatments.
The results suggested that ginger root possibly has moderate beneficial effects on running-induced soreness but irrelevant effects on recovery of physical performance.
Dr. Wilson PB, said, "Ginger represents one option for runners looking to temporarily reduce pain".
Furthermore, in the findings, a natural ingredient for the treatment of inflammation and pain induced by delayed onset muscle soreness (DOMS), a joint study led by Shiraz University, was launched to examine the effect of ginger extract on the biochemical and functional symptom of delayed onset muscle soreness.
36 healthy female subjects included in the study were recruited by intra-dormitory calls and randomly divided into 3 groups, including ginger intake 1 hour before exercise (GIBE), ginger intake immediately after exercise (GIAE), and placebo group (PL).
Participants consumed capsules containing 60 mg of ginger extract (the equivalent of 2 g dried ginger powder) or a placebo before and after exercise. The exercise protocol consisted of a 20-minute step test using a 46cm step at a rate of 15 steps per minute.
Ginger intake immediately after exercise (GIAE) showed a significant reduction of pain compared to GIAE after 24 and 48h of EE and GIAE compared to PL.
The inflammatory cytokine IL-6 changed significantly in GIBE compared to PL (p<0.05) after 1, 24, and 48h after EE.
These results indicated that 2 grams of ginger may have anti-inflammation and analgesic effects on DOMS.
Taken altogether, ginger root may be considered a functional painkiller kitchen spice for the deduction of muscle pain and soreness if it is intake 1 hour before exercise.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) A Randomized Double-Blind Trial of Ginger Root for Reducing Muscle Soreness and Improving Physical Performance Recovery Among Experienced Recreational Distance Runners.
Wilson PB. (PubMed)
(2) Acute effects of ginger extract on biochemical and functional symptoms of delayed onset muscle soreness by Hoseinzadeh K1, Daryanoosh F2, Baghdasar PJ3, Alizadeh H. (PubMed)
#Antioxidant #Alliin Isolated from #Garlic Gobbles Up #BreastCancer Cells, According to Studies
By Kyle J. Norton
Breast cancer is the medical condition caused the irregular cell growth in the breast tissue due to the alternation of cell DNA.
According to the statistic, in 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Most cases of breast cancer begin in the cells on the surface of inner lining tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the early stage, breast cancer is a painless lump in the breast or armpit. However, at the later stage, most women with breast cancer may experience symptoms of nipple discharge (clear or bloody)
inverted or retracted nipple, scaly or pitted skin on nipple, persistent tenderness of the breast and
unusual breast pain or discomfort.
According to statistics, the 5 years survival rate of early diagnosed breast cancer is closed to 100%.
However, in the rare case of aggressive inflammatory breast cancer (IBC) that induces the growth in sheets instead of lumps and invades nearby skin, the whole breast may go suddenly red and feel hot, resembling an inflammation.
The disease only occurs in 1-6% of all breast cancer cases in the USA. Women with IBC are first treated with chemotherapy before surgery. On average, the 5-year survival rate of women diagnosed with inflammatory breast cancer is 34% compared to the early stage of breast cancer of 100%.
Out of many risk factors associated with the risk of breast cancer, the genetic proposition is one of the factors that may predict the onset of the disease.
Dr. Turnbull C, the lead scientist said, "BRCA1 and BRCA2 are high-penetrance breast cancer predisposition genes identified by genome-wide linkage analysis and positional cloning. Mutational screening of genes functionally related to BRCA1 and/or BRCA2 has revealed four genes, CHEK2, ATM, BRIP1, and PALB2; mutations in these genes are rare and confer an intermediate risk of breast cancer".
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, and a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
On finding a natural potential for the treatment of breast cancer, researchers examined the combination of garlic-derived S-allyl-L-cysteine sulfoxide (alliin) and paclitaxel (PTX) effect on breast adenocarcinoma MCF-7 cells.
According to the Western blotting assay, alliin and PTX worked synergistically to promote and potentiate apoptosis in MCF-7 cells by inhibiting the altered expression of importin-9 (IPO9) involved in transcription, cell signaling, and cell cycle regulation.
Furthermore, the inhibition of the IPO9 expression was also found to correlate with a significant reduction in the apoptotic cell population as well as with a decrease in F-actin content in the cancer cells, leading to alteration of cell DNA and in the cortical and nuclear/perinuclear areas of the cells.
Simultaneously, the inhibition of IPO9 by alliin and PTX was also accompanied by the increased post-translational expression of CFL1 associated with the reduction of cell proliferation and metastasis.
In other words, garlic-derived S-allyl-L-cysteine sulfoxide (alliin) and paclitaxel (PTX) induced breast cancer MCF-7 cell death by inhibiting the protein associated with cell differentiation and division through the reduction of cell proliferation and metastasis.
The combined compound exhibited anti-MCF-7 cell activity by targeting and modulating the cytoskeleton present in the cytoplasm of cancer cells through some aforementioned mechanisms.
Taken altogether, alliin used alone or combined with primary medicine may be used for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Downregulation of importin-9 protects MCF-7 cells against apoptosis induced by the combination of garlic-derived alliin and paclitaxel by Izdebska M1, Grzanka D2, Gagat M1, Hałas-Wiśniewska M1, Grzanka A. (PubMed)
(2) Genetic predisposition to breast cancer: past, present, and future by Turnbull C1, Rahman N. (PubMed)
Breast cancer is the medical condition caused the irregular cell growth in the breast tissue due to the alternation of cell DNA.
According to the statistic, in 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Most cases of breast cancer begin in the cells on the surface of inner lining tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the early stage, breast cancer is a painless lump in the breast or armpit. However, at the later stage, most women with breast cancer may experience symptoms of nipple discharge (clear or bloody)
inverted or retracted nipple, scaly or pitted skin on nipple, persistent tenderness of the breast and
unusual breast pain or discomfort.
According to statistics, the 5 years survival rate of early diagnosed breast cancer is closed to 100%.
However, in the rare case of aggressive inflammatory breast cancer (IBC) that induces the growth in sheets instead of lumps and invades nearby skin, the whole breast may go suddenly red and feel hot, resembling an inflammation.
The disease only occurs in 1-6% of all breast cancer cases in the USA. Women with IBC are first treated with chemotherapy before surgery. On average, the 5-year survival rate of women diagnosed with inflammatory breast cancer is 34% compared to the early stage of breast cancer of 100%.
Out of many risk factors associated with the risk of breast cancer, the genetic proposition is one of the factors that may predict the onset of the disease.
Dr. Turnbull C, the lead scientist said, "BRCA1 and BRCA2 are high-penetrance breast cancer predisposition genes identified by genome-wide linkage analysis and positional cloning. Mutational screening of genes functionally related to BRCA1 and/or BRCA2 has revealed four genes, CHEK2, ATM, BRIP1, and PALB2; mutations in these genes are rare and confer an intermediate risk of breast cancer".
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, and a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
On finding a natural potential for the treatment of breast cancer, researchers examined the combination of garlic-derived S-allyl-L-cysteine sulfoxide (alliin) and paclitaxel (PTX) effect on breast adenocarcinoma MCF-7 cells.
According to the Western blotting assay, alliin and PTX worked synergistically to promote and potentiate apoptosis in MCF-7 cells by inhibiting the altered expression of importin-9 (IPO9) involved in transcription, cell signaling, and cell cycle regulation.
Furthermore, the inhibition of the IPO9 expression was also found to correlate with a significant reduction in the apoptotic cell population as well as with a decrease in F-actin content in the cancer cells, leading to alteration of cell DNA and in the cortical and nuclear/perinuclear areas of the cells.
Simultaneously, the inhibition of IPO9 by alliin and PTX was also accompanied by the increased post-translational expression of CFL1 associated with the reduction of cell proliferation and metastasis.
In other words, garlic-derived S-allyl-L-cysteine sulfoxide (alliin) and paclitaxel (PTX) induced breast cancer MCF-7 cell death by inhibiting the protein associated with cell differentiation and division through the reduction of cell proliferation and metastasis.
The combined compound exhibited anti-MCF-7 cell activity by targeting and modulating the cytoskeleton present in the cytoplasm of cancer cells through some aforementioned mechanisms.
Taken altogether, alliin used alone or combined with primary medicine may be used for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Downregulation of importin-9 protects MCF-7 cells against apoptosis induced by the combination of garlic-derived alliin and paclitaxel by Izdebska M1, Grzanka D2, Gagat M1, Hałas-Wiśniewska M1, Grzanka A. (PubMed)
(2) Genetic predisposition to breast cancer: past, present, and future by Turnbull C1, Rahman N. (PubMed)
#Healthyfood #Tomatoes in the Promotion of #SkinHealthy, Scientists Show
By Kyle J. Norton
Tomatoes may have a profound and positive effect on improved skin health, some scientists suggested.
The results of the analysis were carried out by several universities and research companies, including IUF - Leibniz Research Institute for Environmental Medicine and published on numbers of online literature.
Tomato is red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. Because of its health benefits, tomato is grown worldwide for commercial purpose
and often in the greenhouse.
In the aim to reaffirm tomatoes effect in reduced negative impact against ultraviolet (UV)A/B and UVA1 radiation at a molecular level, scientists at the IUF - Leibniz Research Institute for Environmental Medicine launched a study of the tomato bioactive compounds lutein and lycopene photoprotective effect on human skin health.
The purpose of the study was to assess the two active treatments containing either lycopene (TNC) or lutein to test for their capacity in decreased expression of UVA1 the radiation-inducible genes HO1, ICAM1, and MMP1
Gene heme oxygenase 1 (HO1) is an enzyme with the function to protect cells from oxidative damage, in this case, it was the UVA1
Gene intercellular adhesion molecule 1 (ICAM1) also known as CD54 (Cluster of Differentiation 54) is a protein with function in adhesion phenomena involved in the immune response.
Matrix metalloproteinase-1 (MMP-1) also known as interstitial collagenase and fibroblast collagenase is an enzyme with the function to break down collagens located in the ECM.
The placebo-controlled, double-blinded, randomized, crossover study included 65 healthy volunteers allocated to four treatment groups and subjected to a 2-week washout phase, followed by two 12-week treatment phases separated by another 2 weeks of washout.
Volunteers started either with active treatment and were then switched to placebo, or vice versa.
24 hours after the irradiation phase skin, biopsies were taken from untreated, UVA/B- and UVA1-irradiated skin for subsequent reverse transcriptase-polymerase chain reaction analysis of gene expression.
Interestingly, after taking into account other co and confounders, researchers found that lycopene isolated from tomato exerts strong activities in completely inhibited UVA1- and UVA/B-induced upregulation of heme-oxygenase 1, intercellular adhesion molecule 1, and matrix metallopeptidase 1, through restricting the transformation of mRNA in initiated cell changes.
Blood samples taken from the lycopene treatment group showed a clinically relative protective effect on skin cells through its inhibition of levels of oxidative stress induced by UVA1- and UVA/B exposure in comparison to other groups.
Compared to the lycopene active group, the group treated with lutein injection provided complete protection taken in the first period but showed insignificant effects in the second sequence.
These results suggested that there must be some unknown mechanisms to cause reduced levels of
lutein in the second sequence compared to TNC.
Dr. Grether-Beck S, the lead author said, " the role of these genes as indicators of oxidative stress, photodermatoses, and photoaging" and " these results might indicate that TNC and lutein could protect against solar radiation-induced health damage".
Furthermore, in re-evaluating the effect of Carotenoids in skin photoprotection against UV radiation through analysis of the collection of dermal biopsies of healthy humans (N=27) and blood samples, researchers reconfirmed that lycopene and beta-carotene made up the majority of carotenoids in both skin and plasma followed by beta-cryptoxanthin.
These expressions suggested that lycopene and beta-carotene may play an important role in improved skin health through their antioxidant activity compared to other members of carotenoids such as
dihydroxy carotenoids, lutein, and zeaxanthin.
In other words, the skin of humans is relatively enriched in lycopene and beta-carotene, compared to lutein and zeaxanthin, possibly reflecting a specific function of hydrocarbon carotenoids in human skin photoprotection.
Additionally, in the examination the skin collected from 74 men and women with diverse skin pigmentation using the Resonance Raman spectroscopy (RRS) to measure the palm, inner arm, and outer arm were obtained at baseline, 1 wk, 2 wk, 1 mo, 3 mo, and 6 mo (to maximize seasonal variation), researchers with no surprise found that total carotenoids across time are 0.97 (palm), 0.95 (inner arm), and 0.93 (outer arm).
Similarly, the assessment of lycopene by RRS was significantly correlated with lycopene assessed by HPLC of dermal biopsies (r = 0.74, P < 0.0001).
These findings once again indicated the protective effect of tomato and the bioactive ingredient lycopene on skin health compared to other compounds.
Taken together, there is no doubt that tomato with its major bioactive phytochemicals may be considered a functional food for improved skin health against skin damage caused by a number of negative implications including oxidative stress, photodermatoses, and photoaging
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Molecular evidence that oral supplementation with lycopene or lutein protects human skinagainst ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study by Grether-Beck S1, Marini A1, Jaenicke T1, Stahl W2, Krutmann J1(PubMed)
(2) Significant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults by Scarmo S1, Cartmel B, Lin H, Leffell DJ, Welch E, Bhosale P, Bernstein PS, Mayne ST(PubMed)
(3) Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake by Mayne ST1, Cartmel B, Scarmo S, Lin H, Leffell DJ, Welch E, Ermakov I, Bhosale P, Bernstein PS, Gellermann W.(PubMed)
Tomatoes may have a profound and positive effect on improved skin health, some scientists suggested.
The results of the analysis were carried out by several universities and research companies, including IUF - Leibniz Research Institute for Environmental Medicine and published on numbers of online literature.
Tomato is red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America. Because of its health benefits, tomato is grown worldwide for commercial purpose
and often in the greenhouse.
In the aim to reaffirm tomatoes effect in reduced negative impact against ultraviolet (UV)A/B and UVA1 radiation at a molecular level, scientists at the IUF - Leibniz Research Institute for Environmental Medicine launched a study of the tomato bioactive compounds lutein and lycopene photoprotective effect on human skin health.
The purpose of the study was to assess the two active treatments containing either lycopene (TNC) or lutein to test for their capacity in decreased expression of UVA1 the radiation-inducible genes HO1, ICAM1, and MMP1
Gene heme oxygenase 1 (HO1) is an enzyme with the function to protect cells from oxidative damage, in this case, it was the UVA1
Gene intercellular adhesion molecule 1 (ICAM1) also known as CD54 (Cluster of Differentiation 54) is a protein with function in adhesion phenomena involved in the immune response.
Matrix metalloproteinase-1 (MMP-1) also known as interstitial collagenase and fibroblast collagenase is an enzyme with the function to break down collagens located in the ECM.
The placebo-controlled, double-blinded, randomized, crossover study included 65 healthy volunteers allocated to four treatment groups and subjected to a 2-week washout phase, followed by two 12-week treatment phases separated by another 2 weeks of washout.
Volunteers started either with active treatment and were then switched to placebo, or vice versa.
24 hours after the irradiation phase skin, biopsies were taken from untreated, UVA/B- and UVA1-irradiated skin for subsequent reverse transcriptase-polymerase chain reaction analysis of gene expression.
Interestingly, after taking into account other co and confounders, researchers found that lycopene isolated from tomato exerts strong activities in completely inhibited UVA1- and UVA/B-induced upregulation of heme-oxygenase 1, intercellular adhesion molecule 1, and matrix metallopeptidase 1, through restricting the transformation of mRNA in initiated cell changes.
Blood samples taken from the lycopene treatment group showed a clinically relative protective effect on skin cells through its inhibition of levels of oxidative stress induced by UVA1- and UVA/B exposure in comparison to other groups.
Compared to the lycopene active group, the group treated with lutein injection provided complete protection taken in the first period but showed insignificant effects in the second sequence.
These results suggested that there must be some unknown mechanisms to cause reduced levels of
lutein in the second sequence compared to TNC.
Dr. Grether-Beck S, the lead author said, " the role of these genes as indicators of oxidative stress, photodermatoses, and photoaging" and " these results might indicate that TNC and lutein could protect against solar radiation-induced health damage".
Furthermore, in re-evaluating the effect of Carotenoids in skin photoprotection against UV radiation through analysis of the collection of dermal biopsies of healthy humans (N=27) and blood samples, researchers reconfirmed that lycopene and beta-carotene made up the majority of carotenoids in both skin and plasma followed by beta-cryptoxanthin.
These expressions suggested that lycopene and beta-carotene may play an important role in improved skin health through their antioxidant activity compared to other members of carotenoids such as
dihydroxy carotenoids, lutein, and zeaxanthin.
In other words, the skin of humans is relatively enriched in lycopene and beta-carotene, compared to lutein and zeaxanthin, possibly reflecting a specific function of hydrocarbon carotenoids in human skin photoprotection.
Additionally, in the examination the skin collected from 74 men and women with diverse skin pigmentation using the Resonance Raman spectroscopy (RRS) to measure the palm, inner arm, and outer arm were obtained at baseline, 1 wk, 2 wk, 1 mo, 3 mo, and 6 mo (to maximize seasonal variation), researchers with no surprise found that total carotenoids across time are 0.97 (palm), 0.95 (inner arm), and 0.93 (outer arm).
Similarly, the assessment of lycopene by RRS was significantly correlated with lycopene assessed by HPLC of dermal biopsies (r = 0.74, P < 0.0001).
These findings once again indicated the protective effect of tomato and the bioactive ingredient lycopene on skin health compared to other compounds.
Taken together, there is no doubt that tomato with its major bioactive phytochemicals may be considered a functional food for improved skin health against skin damage caused by a number of negative implications including oxidative stress, photodermatoses, and photoaging
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Molecular evidence that oral supplementation with lycopene or lutein protects human skinagainst ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study by Grether-Beck S1, Marini A1, Jaenicke T1, Stahl W2, Krutmann J1(PubMed)
(2) Significant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults by Scarmo S1, Cartmel B, Lin H, Leffell DJ, Welch E, Bhosale P, Bernstein PS, Mayne ST(PubMed)
(3) Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake by Mayne ST1, Cartmel B, Scarmo S, Lin H, Leffell DJ, Welch E, Ermakov I, Bhosale P, Bernstein PS, Gellermann W.(PubMed)
The #Psychological, #Immune and #Infantilecolic Effects of #Herbal #Fennel, According to Studies
By Kyle J. Norton
Fennel may have a profound and positive effect on the reduced risk of infantile colic, some scientists suggest.
Infantile colic is a reaction of the infant if episodes of crying for more than three hours a day, for more than three days a week, for three weeks in an otherwise healthy child. The condition has a strong impact on the psychological, emotional, and physical burden on parents.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In a randomized, double-blind, placebo-controlled trial to investigate the effectiveness and side effects of a phytotherapeutic agent with Matricariae recutita, Foeniculum vulgare, and Melissa officinalis in the treatment of infantile colic in a total of 93 breastfed colicky infants conducted by the John Wiley & Sons, Ltd, after a 3 day observation period, the infants randomly assigned to groups treated with the phytotherapeutic agent (PA) and the group received placebo twice a day for 1 week, researchers found that crying time in the group received PA was reduced substantially in 85.4% of subjects in compared to 48.9% subjects in placebo group against a baseline.
The PA treatment group exerted no side effects during the period of the experiment.
Based on the result, researchers suggested that PA demonstrated a significant activity within one week of application in infantile colic.
Furthermore, the St. Petersburg Medical Academy of Postdoctoral Education the concerns with the side effects of 5% of infants treated with dicyclomine hydrochloride, the only pharmacological treatment for infantile colic, with substantial side effects, including death, conducted a randomized placebo-controlled trial of 125 infants, 2 to 12 weeks of age from 2 large multi-specialty clinics by assigning them to either group treated with fennel or placebo, indicated that fennel treatment group improves the crying time episodes and frequency significantly in compared to the placebo group.
According to the Wessel assay, infantile colic was reduced by 65% (40/62) in the treatment group compared to only 23.7% (14/59) in the placebo.
Further analysis also found that the application of fennel induced a risk reduction of 41% compared to the placebo without causing any side effects.
Although the causes of infantile colic are unknown, some researchers suggested that the results of fennel in the treatment of infantile colic may be attributed to its efficacy in the hypothetical conditions catalyzed by
*Abnormal gastrointestinal function caused by imbalanced the bacterial ratio
According to the literature reported by Swansea University, the application of fennel essential oil has a sustainable effect in inhibiting E. coli growth, observed by disc diffusion assays and in liquid culture.
These results were illustrated by the effect of an aqueous extract of the aerial part and aqueous extract of seed samples of fennel.
Fennel inhibited the overgrowth of Agrobacterium radiobacter pv. tumefaciens, Erwinia carotovora, Pseudomonas fluorescens, andPseudomonas glycinea, Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Pseudomona aeruginosa, Salmonella typhi, Salmonella typhimurium, Shigella flexneri, and Bacillus cereus in maintenance integrity of digestive function.
Further differentiation also suggested that fennel has a strong impact on protected gastric damage through significantly increased nitrite, nitrate, ascorbic acid, retinol, and beta-carotene levels.
Dr. Shamkant B. Badgujar, the lead author, in the differentiation of fennel, in regard to the gastrointestinal effect, said, "Foeniculum vulgare is indicated in the treatment of spastic gastrointestinal disturbances, in some forms of chronic colitis (which resist other treatments), in dyspepsias from gastrointestinal atony, in dyspepsias with the sensation of heaviness in the stomach, and so forth. The addition of fennel to preparations containing anthraquinone components reduces the occurrence of abdominal pain often associated with this type of laxative"
* In the Psychological aspect of the mother such as the mother’s depression, anxiety, and distress during pregnancy in the induction of infantile colic, although there is no direct literature to confirm the efficacy of fennel in treating syndromes of this group of women, in the study of psychological symptoms in women with premenstrual syndrome, application of fennel seed was associated in decreased depression and anxiety.
Also, in stress-induced maternal anxiety and depression, the application of fennel extract (50, 100, and 200 mg/kg body weight) showed a significant improvement of urinary levels of vanillyl mandelic acid(VMA) and ascorbic acid excretion levels in the measurement of potential psychological stress in the fennel treatment group in compared to the normal group.
These results indicated that the extract of the entire plant of F. vulgare pay has a potential effect by acting as an anti-stress agent in reducing depression and anxiety in maternity.
* In the food allergic aspect, although there are no direct studies on the expression of a fennel-improved immune response against food allergy,.
Some researchers postulated that anethole, a bioactive compound from fennel inhibited food allergy probably through enhancing the immune system's food hypersensitivity response by modulating the expression of Foxp3+ in regulated the development and function T cells and inhibition of Th2 cytokines in promoted antibodies production of immunoglobulin E (IgE), thus reducing immune system overreacts to an allergen.
Taken together, the findings suggested that fennel may be considered as a functional food for the treatment of infantile colic, however, a large sample size and study by multi centers are necessary to reconfirm the viability.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) A randomized double-blind placebo-controlled trial of a standardized extract of Matricariae recutita, Foeniculum vulgare, and Melissa officinalis (ColiMil) in the treatment of breastfed colicky infants by Savino F1, Cresi F, Castagno E, Silvestro L, Oggero R.(PubMed)
(2) The effect of fennel (Foeniculum Vulgare) seed oil emulsion in infantile colic: a randomized, placebo-controlled study by Alexandrovich I1, Rakovitskaya O, Kolmo E, Sidorova T, Shushunov S.(PubMed)
(3) Illicium verum Extract and Trans-Anethole Attenuate Ovalbumin-Induced Airway Inflammation via Enhancement of Foxp3+ Regulatory T Cells and Inhibition of Th2 Cytokines in Mice by Yoon-Young Sung,1 Seung-Hyung Kim,2 Dong-Seon Kim,3 Ji-eun Lee,2 and Ho Kyoung Kim1(Hidawi)
(4) Comparison of the antibacterial activity of essential oils and extracts of medicinal and culinary herbs to investigate potential new treatments for irritable bowel syndrome by Thompson A1, Meah D, Ahmed N, Conniff-Jenkins R, Chileshe E, Phillips CO, Claypole TC, Forman DW, Row PE.(PubMed)
(5) Comparing the Effects of Echinophora-platyloba, Fennel and Placebo on Pre-menstrual Syndrome by Masoumeh Delaram,1,* Soleiman Kheiri,2 and Mohammad Reza Hodjati(PMC)
Fennel may have a profound and positive effect on the reduced risk of infantile colic, some scientists suggest.
Infantile colic is a reaction of the infant if episodes of crying for more than three hours a day, for more than three days a week, for three weeks in an otherwise healthy child. The condition has a strong impact on the psychological, emotional, and physical burden on parents.
Fennel (Foeniculum vulgare) is a plant species of the genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as a warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In a randomized, double-blind, placebo-controlled trial to investigate the effectiveness and side effects of a phytotherapeutic agent with Matricariae recutita, Foeniculum vulgare, and Melissa officinalis in the treatment of infantile colic in a total of 93 breastfed colicky infants conducted by the John Wiley & Sons, Ltd, after a 3 day observation period, the infants randomly assigned to groups treated with the phytotherapeutic agent (PA) and the group received placebo twice a day for 1 week, researchers found that crying time in the group received PA was reduced substantially in 85.4% of subjects in compared to 48.9% subjects in placebo group against a baseline.
The PA treatment group exerted no side effects during the period of the experiment.
Based on the result, researchers suggested that PA demonstrated a significant activity within one week of application in infantile colic.
Furthermore, the St. Petersburg Medical Academy of Postdoctoral Education the concerns with the side effects of 5% of infants treated with dicyclomine hydrochloride, the only pharmacological treatment for infantile colic, with substantial side effects, including death, conducted a randomized placebo-controlled trial of 125 infants, 2 to 12 weeks of age from 2 large multi-specialty clinics by assigning them to either group treated with fennel or placebo, indicated that fennel treatment group improves the crying time episodes and frequency significantly in compared to the placebo group.
According to the Wessel assay, infantile colic was reduced by 65% (40/62) in the treatment group compared to only 23.7% (14/59) in the placebo.
Further analysis also found that the application of fennel induced a risk reduction of 41% compared to the placebo without causing any side effects.
Although the causes of infantile colic are unknown, some researchers suggested that the results of fennel in the treatment of infantile colic may be attributed to its efficacy in the hypothetical conditions catalyzed by
*Abnormal gastrointestinal function caused by imbalanced the bacterial ratio
According to the literature reported by Swansea University, the application of fennel essential oil has a sustainable effect in inhibiting E. coli growth, observed by disc diffusion assays and in liquid culture.
These results were illustrated by the effect of an aqueous extract of the aerial part and aqueous extract of seed samples of fennel.
Fennel inhibited the overgrowth of Agrobacterium radiobacter pv. tumefaciens, Erwinia carotovora, Pseudomonas fluorescens, andPseudomonas glycinea, Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Pseudomona aeruginosa, Salmonella typhi, Salmonella typhimurium, Shigella flexneri, and Bacillus cereus in maintenance integrity of digestive function.
Further differentiation also suggested that fennel has a strong impact on protected gastric damage through significantly increased nitrite, nitrate, ascorbic acid, retinol, and beta-carotene levels.
Dr. Shamkant B. Badgujar, the lead author, in the differentiation of fennel, in regard to the gastrointestinal effect, said, "Foeniculum vulgare is indicated in the treatment of spastic gastrointestinal disturbances, in some forms of chronic colitis (which resist other treatments), in dyspepsias from gastrointestinal atony, in dyspepsias with the sensation of heaviness in the stomach, and so forth. The addition of fennel to preparations containing anthraquinone components reduces the occurrence of abdominal pain often associated with this type of laxative"
* In the Psychological aspect of the mother such as the mother’s depression, anxiety, and distress during pregnancy in the induction of infantile colic, although there is no direct literature to confirm the efficacy of fennel in treating syndromes of this group of women, in the study of psychological symptoms in women with premenstrual syndrome, application of fennel seed was associated in decreased depression and anxiety.
Also, in stress-induced maternal anxiety and depression, the application of fennel extract (50, 100, and 200 mg/kg body weight) showed a significant improvement of urinary levels of vanillyl mandelic acid(VMA) and ascorbic acid excretion levels in the measurement of potential psychological stress in the fennel treatment group in compared to the normal group.
These results indicated that the extract of the entire plant of F. vulgare pay has a potential effect by acting as an anti-stress agent in reducing depression and anxiety in maternity.
* In the food allergic aspect, although there are no direct studies on the expression of a fennel-improved immune response against food allergy,.
Some researchers postulated that anethole, a bioactive compound from fennel inhibited food allergy probably through enhancing the immune system's food hypersensitivity response by modulating the expression of Foxp3+ in regulated the development and function T cells and inhibition of Th2 cytokines in promoted antibodies production of immunoglobulin E (IgE), thus reducing immune system overreacts to an allergen.
Taken together, the findings suggested that fennel may be considered as a functional food for the treatment of infantile colic, however, a large sample size and study by multi centers are necessary to reconfirm the viability.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) A randomized double-blind placebo-controlled trial of a standardized extract of Matricariae recutita, Foeniculum vulgare, and Melissa officinalis (ColiMil) in the treatment of breastfed colicky infants by Savino F1, Cresi F, Castagno E, Silvestro L, Oggero R.(PubMed)
(2) The effect of fennel (Foeniculum Vulgare) seed oil emulsion in infantile colic: a randomized, placebo-controlled study by Alexandrovich I1, Rakovitskaya O, Kolmo E, Sidorova T, Shushunov S.(PubMed)
(3) Illicium verum Extract and Trans-Anethole Attenuate Ovalbumin-Induced Airway Inflammation via Enhancement of Foxp3+ Regulatory T Cells and Inhibition of Th2 Cytokines in Mice by Yoon-Young Sung,1 Seung-Hyung Kim,2 Dong-Seon Kim,3 Ji-eun Lee,2 and Ho Kyoung Kim1(Hidawi)
(4) Comparison of the antibacterial activity of essential oils and extracts of medicinal and culinary herbs to investigate potential new treatments for irritable bowel syndrome by Thompson A1, Meah D, Ahmed N, Conniff-Jenkins R, Chileshe E, Phillips CO, Claypole TC, Forman DW, Row PE.(PubMed)
(5) Comparing the Effects of Echinophora-platyloba, Fennel and Placebo on Pre-menstrual Syndrome by Masoumeh Delaram,1,* Soleiman Kheiri,2 and Mohammad Reza Hodjati(PMC)
#Cucumbers's #Cucurbitacin B (CuB) Kills Melanoma in Vitros and Vivos, Researchers Say
By Kyle J. Norton
Melanoma is a type of skin cancer associated with the alternation of DNA in the pigment-containing cells.
Melanin is a pigment that gives skin, hair, and eyes their color.
Malignant melanin cells (melanocytes) lead to the formation of moles on the skin usually brown or pink in color.
Skin is the largest organ in the body which not only processes a unique function by protecting our body through its covering but also is a third detoxed organ that eliminates toxins from our body in cases the kidney and liver failure.
Epidemiologically, certain risk factors such as exposure to ultraviolet radiation (UVR), genetic preposition such as CDKN2A gene mutation, people with light colored skin, and personal and family history of skin cancer are associated with the onset of melanoma.
However, most people with some of the aforementioned risk factors have not developed melanoma.
Out of many risk factors, long-term contact with ultraviolet radiation (UVR) is the most common risk factor found in skin cancer in the US.
Dr. Wang SQ, the lead scientist at the New York University School of Medicine, wrote, "The incidence and mortality rates of melanoma have risen for many decades in the United States. Increased exposure to ultraviolet (UV) radiation is generally considered to be responsible. Sunburns, a measure of excess sun exposure, has been identified as a risk factor for the development of melanoma".
And, "Because sunburns are primarily due to UVB (280-320 nm) radiation, UVB has been implicated as a potential contributing factor to the pathogenesis of melanoma. The adverse role of UVA (320-400 nm) in this regard is less well studied".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a potential compound for the treatment of cancer, researchers examined the effects of Cucurbitacin B (CuB), a triterpenoid compound isolated from cucumber, against melanoma B16 cells.
According to the tested assays, CuB exerted significant inhibitory effects on cell proliferation, colony formation, cell migration, and invasion potential of the melanoma cells.
In vivo, CuB significantly inhibited the growth of subcutaneous melanoma in mice compared to the control.
Furthermore, the injection of CuB treatment induced rapid cancer cell membrane blebbing and deformation and induced G(2)/M-phase arrest and cell proliferation.
Moreover, CuB also induced overexpression of ROS in facilitating the cytotoxic activity against the tested cell lines through rapid depletion of the protein involved in the formation of microfilaments.
Dr. Zhang Y, the lead scientist said, " These findings indicate that CuB induces rapid depletion of the G-actin pool through ROS-dependent actin aggregation in melanoma cells, which may at least partly account for its anti-tumor activity".
Additionally, CuB inhibited the proliferation of the cell line and was found to be in a dose-dependent manner, involving the induction of autophagy and exhibiting the function of a protein associated with anti-apoptosis.
Combined with chloroquine, a well-known autophagy inhibitor, the combination showed more sensitivity to the tested melanoma cells.
In other words, CuB improved the efficacy of chloroquine against melanoma while reducing the medicine's side effects.
Taken altogether, cucumber processed with a high amount of CuB may be considered a natural remedy for the prevention and treatment of melanoma, pending the confirmation of a larger sample size and multicenter human study
Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells by Zhang Y1, Ouyang D, Xu L, Ji Y, Zha Q, Cai J, He X. (PubMed)
(2) Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment by Ouyang D1, Zhang Y, Xu L, Li J, Zha Q, He X. (PubMed)
(3) Ultraviolet A and melanoma: a review by Wang SQ1, Setlow R, Berwick M, Polsky D, Marghoob AA, Kopf AW, Bart RS. (PubMed)
Melanoma is a type of skin cancer associated with the alternation of DNA in the pigment-containing cells.
Melanin is a pigment that gives skin, hair, and eyes their color.
Malignant melanin cells (melanocytes) lead to the formation of moles on the skin usually brown or pink in color.
Skin is the largest organ in the body which not only processes a unique function by protecting our body through its covering but also is a third detoxed organ that eliminates toxins from our body in cases the kidney and liver failure.
Epidemiologically, certain risk factors such as exposure to ultraviolet radiation (UVR), genetic preposition such as CDKN2A gene mutation, people with light colored skin, and personal and family history of skin cancer are associated with the onset of melanoma.
However, most people with some of the aforementioned risk factors have not developed melanoma.
Out of many risk factors, long-term contact with ultraviolet radiation (UVR) is the most common risk factor found in skin cancer in the US.
Dr. Wang SQ, the lead scientist at the New York University School of Medicine, wrote, "The incidence and mortality rates of melanoma have risen for many decades in the United States. Increased exposure to ultraviolet (UV) radiation is generally considered to be responsible. Sunburns, a measure of excess sun exposure, has been identified as a risk factor for the development of melanoma".
And, "Because sunburns are primarily due to UVB (280-320 nm) radiation, UVB has been implicated as a potential contributing factor to the pathogenesis of melanoma. The adverse role of UVA (320-400 nm) in this regard is less well studied".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a potential compound for the treatment of cancer, researchers examined the effects of Cucurbitacin B (CuB), a triterpenoid compound isolated from cucumber, against melanoma B16 cells.
According to the tested assays, CuB exerted significant inhibitory effects on cell proliferation, colony formation, cell migration, and invasion potential of the melanoma cells.
In vivo, CuB significantly inhibited the growth of subcutaneous melanoma in mice compared to the control.
Furthermore, the injection of CuB treatment induced rapid cancer cell membrane blebbing and deformation and induced G(2)/M-phase arrest and cell proliferation.
Moreover, CuB also induced overexpression of ROS in facilitating the cytotoxic activity against the tested cell lines through rapid depletion of the protein involved in the formation of microfilaments.
Dr. Zhang Y, the lead scientist said, " These findings indicate that CuB induces rapid depletion of the G-actin pool through ROS-dependent actin aggregation in melanoma cells, which may at least partly account for its anti-tumor activity".
Additionally, CuB inhibited the proliferation of the cell line and was found to be in a dose-dependent manner, involving the induction of autophagy and exhibiting the function of a protein associated with anti-apoptosis.
Combined with chloroquine, a well-known autophagy inhibitor, the combination showed more sensitivity to the tested melanoma cells.
In other words, CuB improved the efficacy of chloroquine against melanoma while reducing the medicine's side effects.
Taken altogether, cucumber processed with a high amount of CuB may be considered a natural remedy for the prevention and treatment of melanoma, pending the confirmation of a larger sample size and multicenter human study
Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells by Zhang Y1, Ouyang D, Xu L, Ji Y, Zha Q, Cai J, He X. (PubMed)
(2) Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment by Ouyang D1, Zhang Y, Xu L, Li J, Zha Q, He X. (PubMed)
(3) Ultraviolet A and melanoma: a review by Wang SQ1, Setlow R, Berwick M, Polsky D, Marghoob AA, Kopf AW, Bart RS. (PubMed)
#GreenBean and #Tomato Extracts in Reducing the Risk of #CardiovascularDiseases (#CVD), Studies Suggest
By Kyle J. Norton
Cardiovascular disease (CVD) is a group of diseases associated with blood vessels and heart muscle.
Depending on the types of blood vessel damage or blocked, and heart muscle damage, CVD can be a coronary artery disease caused by the hardening of the arteries that interfere with the blood flow to the heart or a stroke caused by reducing oxygen supply to the brain cells.
Heart disease is a class of conditions associated with blood vessels and heart muscle that affect heart functioning, including coronary artery disease; heart rhythm problems (arrhythmias); and heart defects.
Coronary artery disease is a condition in most cases associated with an inflammatory cholesterol-containing plaque in the arteries.
A stroke can be caused by reduced blood flow or small blood vessel bleeding, leading to the death of neurons that affect parts of the brain's functioning.
Heart failure, a major health problem associated with the reduced function of the heart affects more than 6.5 million Americans, a leading cause of hospitalization in people older than age 65.
According to the statistics provided by the CDC, every year, heart disease causes the death of 610,000 people in the United States. In other words, every year, 1 in every 4 deaths in the US are caused by heart disease.
Believe it or not, every year about 735,000 Americans have a heart attack including the first attack of 525,000 patients.
There are many prevalent factors associated with cardiovascular disease including family history, age ethnicity, gender, and medical conditions such as cholesterol high blood pressure, and diabetes.
Some researchers suggested overconsumption of carbohydrates over the long term may be one major condition that causes the onset of CVD.
Dr. Norman J. Temple in the examination of the effect of fat, sugar, and whole grains on the risk of heart disease wrote, " The evidence linking carbohydrate-rich foods with CHD has been steadily strengthening. Refined carbohydrates, especially sugar-sweetened beverages, increase the risk of CHD. Conversely, whole grains and cereal fiber are protective. An extra one or 2 servings per day of these foods increases or decreases risk by approximately 10% to 20%.".
In other words, the intake of a high amount of carbohydrates is associated with an increased risk of CVD.
Green bean is a genus of Phaseolus Sensu Stricto, containing 55 different species, belongs to the family Fabaceae, and is native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.
In finding a portent compound for the prevention of cardiovascular disease, researchers compared
the antithrombotic activity in participants in central Chile.
The study included extract samples of 19 fruits and 26 vegetables from the local diet. Prepared from each sample included an aqueous (juice or pressed solubles) and/or methanol-soluble fraction.
According to the results of differentiation, green beans and tomato extracts inhibited the platelet aggregation induced by ADP and arachidonic acid, in a concentration-dependent manner.
However, green beans and tomato extracts showed a lesser effect compared to the methanolic extracts of grapes on prolonged prothrombin time (PT), and diluted prothrombin time (dPT).
Moreover, extracts of raspberry are more effective in prolonged activated partial thromboplastin time (APTT), and fibrinolytic activity compared to the green beans extracts.
Taken altogether, green beans used combined with tomato may be considered a remedy for the prevention of cardiovascular diseases, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables by Torres-Urrutia C1, Guzmán L, Schmeda-Hirschmann G, Moore-Carrasco R, Alarcón M, Astudillo L, Gutierrez M, Carrasco G, Yuri JA, Aranda E, Palomo I. (PubMed)
(2) Fat, Sugar, Whole Grains and Heart Disease: 50 Years of Confusion by Norman J. Temple (PMC)
Cardiovascular disease (CVD) is a group of diseases associated with blood vessels and heart muscle.
Depending on the types of blood vessel damage or blocked, and heart muscle damage, CVD can be a coronary artery disease caused by the hardening of the arteries that interfere with the blood flow to the heart or a stroke caused by reducing oxygen supply to the brain cells.
Heart disease is a class of conditions associated with blood vessels and heart muscle that affect heart functioning, including coronary artery disease; heart rhythm problems (arrhythmias); and heart defects.
Coronary artery disease is a condition in most cases associated with an inflammatory cholesterol-containing plaque in the arteries.
A stroke can be caused by reduced blood flow or small blood vessel bleeding, leading to the death of neurons that affect parts of the brain's functioning.
Heart failure, a major health problem associated with the reduced function of the heart affects more than 6.5 million Americans, a leading cause of hospitalization in people older than age 65.
According to the statistics provided by the CDC, every year, heart disease causes the death of 610,000 people in the United States. In other words, every year, 1 in every 4 deaths in the US are caused by heart disease.
Believe it or not, every year about 735,000 Americans have a heart attack including the first attack of 525,000 patients.
There are many prevalent factors associated with cardiovascular disease including family history, age ethnicity, gender, and medical conditions such as cholesterol high blood pressure, and diabetes.
Some researchers suggested overconsumption of carbohydrates over the long term may be one major condition that causes the onset of CVD.
Dr. Norman J. Temple in the examination of the effect of fat, sugar, and whole grains on the risk of heart disease wrote, " The evidence linking carbohydrate-rich foods with CHD has been steadily strengthening. Refined carbohydrates, especially sugar-sweetened beverages, increase the risk of CHD. Conversely, whole grains and cereal fiber are protective. An extra one or 2 servings per day of these foods increases or decreases risk by approximately 10% to 20%.".
In other words, the intake of a high amount of carbohydrates is associated with an increased risk of CVD.
Green bean is a genus of Phaseolus Sensu Stricto, containing 55 different species, belongs to the family Fabaceae, and is native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.
In finding a portent compound for the prevention of cardiovascular disease, researchers compared
the antithrombotic activity in participants in central Chile.
The study included extract samples of 19 fruits and 26 vegetables from the local diet. Prepared from each sample included an aqueous (juice or pressed solubles) and/or methanol-soluble fraction.
According to the results of differentiation, green beans and tomato extracts inhibited the platelet aggregation induced by ADP and arachidonic acid, in a concentration-dependent manner.
However, green beans and tomato extracts showed a lesser effect compared to the methanolic extracts of grapes on prolonged prothrombin time (PT), and diluted prothrombin time (dPT).
Moreover, extracts of raspberry are more effective in prolonged activated partial thromboplastin time (APTT), and fibrinolytic activity compared to the green beans extracts.
Taken altogether, green beans used combined with tomato may be considered a remedy for the prevention of cardiovascular diseases, pending the confirmation of a larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables by Torres-Urrutia C1, Guzmán L, Schmeda-Hirschmann G, Moore-Carrasco R, Alarcón M, Astudillo L, Gutierrez M, Carrasco G, Yuri JA, Aranda E, Palomo I. (PubMed)
(2) Fat, Sugar, Whole Grains and Heart Disease: 50 Years of Confusion by Norman J. Temple (PMC)
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