By Kyle J. Norton
Ovarian cancer is a chronic medical condition caused by cell growth irregularly in the tissue of the ovary.
Most cases of ovarian cancer begin in the cells on the surface of the inner lining tissue of the ovary before spreading to the deeper layers to form a tumor.
In the very early stage, due to the very small size of the tumor, most patients are asymptomatic. However, as the disease progresses, patients may experience symptoms shared commonly with other types of cancer accompanied by specific symptoms of abdominal bloating or swelling, discomfort in the pelvic area, and changes in bowel habits, such as constipation.
According to the statistics provided by the American Cancer Society, ovarian cancer ranks fifth in cancer deaths among women, accounting for more deaths than any other cancer of the female reproductive system.
A woman's risk of ovarian cancer is 1 in 78. and the risk of the lifetime chance of dying from ovarian cancer is about 1 in 108.
The five-year relative survival rate for all types and stages of ovarian cancer is 47 percent, Cancer diagnosed at the early stage have a 5-year survival rate of over 72%.
The exact causes of ovarian cancer are not known. However, according to epidemiological studies genetics preposition such as BRCA1 and BRCA2, family and history of cancer or endometriosis, aging, reproductive history, and infertility and obesity are some of the prevalent factors involved in the onset of ovarian cancer.
The Canadian Cancer Society in the evaluation of the risk of ovarian cancer in women who are never being pregnant or giving birth wrote, "Women who have never been pregnant have a higher risk of developing ovarian cancer than women who have been pregnant".
And, "Researchers think that the lower risk may be because the hormones that are present during pregnancy have a protective effect. It is possible that the higher risk in women who have never been pregnant is linked to the factors that may make it difficult for her to become pregnant".
In other words, women who have at least one pregnancy are at a lower risk of ovarian cancer compared to women who do not.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a natural and potential compound for the treatment of ovarian cancer without inducing adverse effects, researchers examined the efficacy of preparation including chemical conjugate between daidzein and the garlic enzyme alliinase.
According to the tested assays, the conjugate is specifically bound to ovarian cancer cells, and upon addition of the prodrug alliin by inducing the cytotoxic allicin molecules in killing the cancer cells.
In vivo, the preparation showed a targeting and antitumor effect confirmed by NIR and bioluminescence imaging in the luciferase expression of ovarian cancer cells.
Treatment of ovarian tumor-bearing mice with daidzein-alliinase and alliin effectively attenuated tumor progression during the first 12 days.
Compared to the placebo, only small individual foci of luminescence at the site of tumor cells inoculation were found in the treatment group, according to autopsy.
Interestingly, the preparation did not reveal any additional foci of carcinoma or signs of toxicity, according to the histological examination of organs and tissues.
In other words, the chemical conjugate between daidzein and the garlic enzyme alliinase induced ovarian cancer cells apoptosis through its cytotoxic effects without causing harm to nearby healthy cells.
Based on the findings researchers wrote in the final report, "the targeted alliinase conjugates in the presence of alliin, generated therapeutically effective levels of allicin which were capable of suppressing tumor progression of intraperitoneal ovarian cancer in an animal model".
Taken altogether, alliin used alone or combined with other herbal medicines may be considered supplements for the prevention and treatment of ovarian cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Conjugates of daidzein-alliinase as a targeted pro-drug enzyme system against ovarian carcinoma by Appel E1, Rabinkov A, Neeman M, Kohen F, Mirelman D. (PubMed)
(2) Risk factors for ovarian cancer by the Canadian Cancer Society
Wednesday, 7 June 2023
#Phytochemical #Allicin Shows to Reduce Blood Cholesterol, Triglyceride Levels, and Systolic Blood Pressure in Vivos
By Kyle J. Norton
Allicin, the bioactive ingredient isolated from garlic may have a profound effect on the prevention and treatment of high blood cholesterol with no side effects, according to studies.
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Hyperlipidemia is a condition characterized by abnormally high blood cholesterol in the bloodstream. In other words, the levels of low-density lipoprotein (LDL) are high compared to the high-density lipoprotein (LDL) in the blood.
The ideal blood cholesterol is less than 4 (levels of LDL)/ 1(levels of HDL).
Low-density lipoprotein is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat. However, overexpression of LDL can induce plaque accumulated on the arterial wall, leading to atherosclerosis, a major cause of cardiovascular disease.
Low-density lipoprotein is produced by the liver or from the dietary sources. High-density lipoprotein neutralizes the levels LDL by returning them to the liver.
Some researchers suggested that Diet high in trans fats, saturated fat, sugar, smoking, medical conditions such as diabetes or high blood pressure are associated with the increased risk of high blood cholesterol.
Epidemiological studies indicated a healthy diet that contains a high amount of fruits and vegetables and whole-grain have a positive on blood cholesterol. In other words, hyperlipidemia can be prevented by a healthy diet.
Dr. Heather D. Mann, in the discussion of a healthy in the risk of hyperlipidemia, said, " Dietary modification is effective in achieving and maintaining improved serum lipid levels".
The finding clearly suggested that if you follow the diet with a high in saturated and trans fat, red meat and processed food and low in fruits and vegetables and whole-grain, you are at the increased risk of high blood cholesterol.
High blood cholesterol does not cause symptoms, the American Heart Association recommends that all adults have their cholesterol checked every 4 to 6 years, starting at age 20, the age when cholesterol levels start to go up.
In the study of the effect of allicin on hypercholesterolemia in male ICR mice, the chemical constituent of garlic showed a positive effect not in reducing blood cholesterol, triglycerides, and glucose levels, as well as lowering the hepatic cholesterol storage, but also in decreasing appetite daily.
Other in another study of the same but with rats fed with high cholesterol diet, showed a reduction of blood cholesterol, triglycerides levels, and systolic blood pressure in hypercholesterolemic rats. These results showed that allicin may be considered a potent agent in treating hyper cholesterol in the future.
In finding a natural ingredient for the prevention and treatment of high blood cholesterol, a widespread syndrome found in the Western world, researchers investigated the cholesterol-lowering properties of allicin, a bioactive compound isolated from garlic.
Hypercholesterolemia in male ICR mice selected for the study was given allicin, with doses of 5, 10, or 20 mg/kg body weight was given orally daily for 12 weeks.
After week 12, the body weights of allicin-fed mice were less than those of control mice on a high-cholesterol diet by 38.24 ± 7.94% (P < 0.0001) with 5 mg/kg allicin, 39.28 ± 5.03% (P < 0.0001) with 10 mg/kg allicin, and 41.18 ± 5.00% (P < 0.0001) with 20 mg/kg allicin, respectively.
Allicin fed group also showed the most decrease in daily food consumption compared to the control.
Furthermore, allicin showed a strong effect in reducing blood cholesterol, triglycerides, and glucose levels and caused a significant decrease in lowering hepatic cholesterol storage.
These results suggested that allicin is potential value in a cholesterol-lowering candidate, and may be used for protection against the onset of atherosclerosis.
Moreover, in the evaluation of the effect of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) on the serum cholesterol, triglyceride, glucose, protein, and systolic blood pressure in rats fed with a 2% high cholesterol diet with and without garlic powder for 6 weeks, and control rats were fed normal diet researchers found that* Rats fed with a high cholesterol diet mixed with garlic powder demonstrate a significant reduction in their serum cholesterol levels compared to the control group.
* Serum triglyceride levels were also significantly lowered by garlic powder when compared to control and high cholesterol diet group rats.
* The blood pressure of the high-cholesterol diet animals was significantly higher compared to the animals receiving the control diet.
* The blood pressure of the animals receiving garlic powder and high cholesterol diet was significantly lower as compared to the high cholesterol and control diet group.
Once again, garlic with high amounts of allicin is beneficial in reducing blood cholesterol, triglyceride levels, and systolic blood pressure in hypercholesterolemic rats.
Taken altogether, allicin on the garlic may be used daily for the prevention or treatment of high blood cholesterol with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cholesterol-lowering effect of allicin on hypercholesterolemic ICR mice, Lu Y, He Z, Shen X, Xu X, Fan J, Wu S, Zhang D.(PubMed)
(2) Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet by Ali M, Al-Qattan KK, Al-Enezi F, Khanafer RM, Mustafa T.(PubMed)
(3) Diet Modification for Hyperlipidemia. Individual approach to diet planning and education by Heather D. Mann and Pamela Piotrowski. (PMC)
Allicin, the bioactive ingredient isolated from garlic may have a profound effect on the prevention and treatment of high blood cholesterol with no side effects, according to studies.
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Hyperlipidemia is a condition characterized by abnormally high blood cholesterol in the bloodstream. In other words, the levels of low-density lipoprotein (LDL) are high compared to the high-density lipoprotein (LDL) in the blood.
The ideal blood cholesterol is less than 4 (levels of LDL)/ 1(levels of HDL).
Low-density lipoprotein is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat. However, overexpression of LDL can induce plaque accumulated on the arterial wall, leading to atherosclerosis, a major cause of cardiovascular disease.
Low-density lipoprotein is produced by the liver or from the dietary sources. High-density lipoprotein neutralizes the levels LDL by returning them to the liver.
Some researchers suggested that Diet high in trans fats, saturated fat, sugar, smoking, medical conditions such as diabetes or high blood pressure are associated with the increased risk of high blood cholesterol.
Epidemiological studies indicated a healthy diet that contains a high amount of fruits and vegetables and whole-grain have a positive on blood cholesterol. In other words, hyperlipidemia can be prevented by a healthy diet.
Dr. Heather D. Mann, in the discussion of a healthy in the risk of hyperlipidemia, said, " Dietary modification is effective in achieving and maintaining improved serum lipid levels".
The finding clearly suggested that if you follow the diet with a high in saturated and trans fat, red meat and processed food and low in fruits and vegetables and whole-grain, you are at the increased risk of high blood cholesterol.
High blood cholesterol does not cause symptoms, the American Heart Association recommends that all adults have their cholesterol checked every 4 to 6 years, starting at age 20, the age when cholesterol levels start to go up.
In the study of the effect of allicin on hypercholesterolemia in male ICR mice, the chemical constituent of garlic showed a positive effect not in reducing blood cholesterol, triglycerides, and glucose levels, as well as lowering the hepatic cholesterol storage, but also in decreasing appetite daily.
Other in another study of the same but with rats fed with high cholesterol diet, showed a reduction of blood cholesterol, triglycerides levels, and systolic blood pressure in hypercholesterolemic rats. These results showed that allicin may be considered a potent agent in treating hyper cholesterol in the future.
In finding a natural ingredient for the prevention and treatment of high blood cholesterol, a widespread syndrome found in the Western world, researchers investigated the cholesterol-lowering properties of allicin, a bioactive compound isolated from garlic.
Hypercholesterolemia in male ICR mice selected for the study was given allicin, with doses of 5, 10, or 20 mg/kg body weight was given orally daily for 12 weeks.
After week 12, the body weights of allicin-fed mice were less than those of control mice on a high-cholesterol diet by 38.24 ± 7.94% (P < 0.0001) with 5 mg/kg allicin, 39.28 ± 5.03% (P < 0.0001) with 10 mg/kg allicin, and 41.18 ± 5.00% (P < 0.0001) with 20 mg/kg allicin, respectively.
Allicin fed group also showed the most decrease in daily food consumption compared to the control.
Furthermore, allicin showed a strong effect in reducing blood cholesterol, triglycerides, and glucose levels and caused a significant decrease in lowering hepatic cholesterol storage.
These results suggested that allicin is potential value in a cholesterol-lowering candidate, and may be used for protection against the onset of atherosclerosis.
Moreover, in the evaluation of the effect of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) on the serum cholesterol, triglyceride, glucose, protein, and systolic blood pressure in rats fed with a 2% high cholesterol diet with and without garlic powder for 6 weeks, and control rats were fed normal diet researchers found that* Rats fed with a high cholesterol diet mixed with garlic powder demonstrate a significant reduction in their serum cholesterol levels compared to the control group.
* Serum triglyceride levels were also significantly lowered by garlic powder when compared to control and high cholesterol diet group rats.
* The blood pressure of the high-cholesterol diet animals was significantly higher compared to the animals receiving the control diet.
* The blood pressure of the animals receiving garlic powder and high cholesterol diet was significantly lower as compared to the high cholesterol and control diet group.
Once again, garlic with high amounts of allicin is beneficial in reducing blood cholesterol, triglyceride levels, and systolic blood pressure in hypercholesterolemic rats.
Taken altogether, allicin on the garlic may be used daily for the prevention or treatment of high blood cholesterol with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cholesterol-lowering effect of allicin on hypercholesterolemic ICR mice, Lu Y, He Z, Shen X, Xu X, Fan J, Wu S, Zhang D.(PubMed)
(2) Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet by Ali M, Al-Qattan KK, Al-Enezi F, Khanafer RM, Mustafa T.(PubMed)
(3) Diet Modification for Hyperlipidemia. Individual approach to diet planning and education by Heather D. Mann and Pamela Piotrowski. (PMC)
#Bromelain Improves the Chemotherapy Drugs in the Treatment of #PeritonealMesothelioma, Scientists Suggest
By Kyle J. Norton
Peritoneal mesothelioma is a medical condition characterized by irregular cell growth in the tissues of the abdomen (the peritoneum).
Most cases of peritoneal mesothelioma begin in the cell in the surface of the inner lining of the peritoneum, before penetrating into the deeper layers.
At the early stage, due to the small size of the tumor, patients with peritoneal mesothelioma are asymptomatic.
However, at the later stage, patients may experience symptoms of abdominal pain or swelling due to the larger size tumor has pressed on the nearby nerves tissues and blood vessels, changes in bowel habits, feeling of fullness and night sweat accompanied by the general symptoms shared by other types of cancer, such as unexplained weight loss, gastrointestinal discomforts, and loss of appetite.
According to the statistics provided by the American Cancer Society, compared to other types of cancer mesothelioma is rare, with approximately 2,000 to 3,000 new cases of mesothelioma in the US each year. The asbestos-related mesothelioma only accounts for less than 0.3 percent of all cancer diagnosed in the country.
Peritoneal mesothelioma accounts for less than 20 percent of all mesothelioma cases.
Dr. Rodolfo Fonte, the lead scientist in the examination of the risk of asbestos-induced peritoneal mesothelioma in a construction worker, wrote, "Peritoneal mesothelioma is a rare and aggressive asbestos-related malignancy. We present the case of a 65-year-old man who developed recurrent ascites after having been exposed to asbestos in the building industry for > 40 years".
And, "Occupational history and immunohistochemistry are helpful for the correct diagnosis, which, in turn, is important in relation to prognosis and treatment (adoption of new integrated procedures that seem to promise prolonged survival and increased quality of life), and in relation to medico-legal issues and occupation-related compensation claims following asbestos exposure".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural ingredient for the treatment of peritoneal mesothelioma, researchers examined the effects of Bromelain (cysteine proteinase) effects on Mucin 1 (MUC1), a glycosylation-dependent protein that confers tumors with invasiveness, metastasis, and chemoresistance.
In the study in which researchers compared the efficacy of the application of various concentrations of bromelain after 4 and 72 h and combinations of bromelain and cytotoxic drugs (cisplatin or 5-FU) at 72 h, MUC1-expressing MPM cell lines found that bromelain increased the cytotoxicity of cisplatin significantly in cell lines.
Compared to the aforementioned inhibition, combining fluorouracil with bromelain did not show a significant increase in cytotoxicity.
In other words, bromelain improves chemotherapy depending totally on the types of drugs used for the treatment of peritoneal mesothelioma.
Furthermore, bromelain used alone also showed a significant effect in inducing cell death by apoptosis and autophagy.
On pancreatic and breast cancer cells, injection of bromelain also adversely affected the viability of MUC1 expressing on both cell lines.
Based on the findings, Bromelain used alone or combined with other chemo drugs might have a strong effect on the barrier function of MUC1.
Collectively, bromelain inhibited the progression and proliferation of peritoneal mesothelioma by blocking the activity of gene MUC1.
Dr. Pillai K, the lead scientist said, "Current evidence indicates that bromelain may have the potential of being developed into an effective anticancer agent for MPM".
Taken altogether, bromelain may be considered a supplement for the prevention and treatment of peritoneal mesothelioma, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anticancer effect of bromelain with and without cisplatin or 5-FU on malignant peritoneal mesothelioma cells by Pillai K1, Ehteda A, Akhter J, Chua TC, Morris DL. (PubMed)
(2) Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma by Pillai K1, Akhter J, Chua TC, Morris DL. (PubMed)
(3) Asbestos-induced peritoneal mesothelioma in a construction worker by Rodolfo Fonte, Salvatore Gambettino, Mario Melazzini, Mario Scelsi, Claudio Zanon, andStefano M Candura. (PMC)
Peritoneal mesothelioma is a medical condition characterized by irregular cell growth in the tissues of the abdomen (the peritoneum).
Most cases of peritoneal mesothelioma begin in the cell in the surface of the inner lining of the peritoneum, before penetrating into the deeper layers.
At the early stage, due to the small size of the tumor, patients with peritoneal mesothelioma are asymptomatic.
However, at the later stage, patients may experience symptoms of abdominal pain or swelling due to the larger size tumor has pressed on the nearby nerves tissues and blood vessels, changes in bowel habits, feeling of fullness and night sweat accompanied by the general symptoms shared by other types of cancer, such as unexplained weight loss, gastrointestinal discomforts, and loss of appetite.
According to the statistics provided by the American Cancer Society, compared to other types of cancer mesothelioma is rare, with approximately 2,000 to 3,000 new cases of mesothelioma in the US each year. The asbestos-related mesothelioma only accounts for less than 0.3 percent of all cancer diagnosed in the country.
Peritoneal mesothelioma accounts for less than 20 percent of all mesothelioma cases.
Dr. Rodolfo Fonte, the lead scientist in the examination of the risk of asbestos-induced peritoneal mesothelioma in a construction worker, wrote, "Peritoneal mesothelioma is a rare and aggressive asbestos-related malignancy. We present the case of a 65-year-old man who developed recurrent ascites after having been exposed to asbestos in the building industry for > 40 years".
And, "Occupational history and immunohistochemistry are helpful for the correct diagnosis, which, in turn, is important in relation to prognosis and treatment (adoption of new integrated procedures that seem to promise prolonged survival and increased quality of life), and in relation to medico-legal issues and occupation-related compensation claims following asbestos exposure".
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural ingredient for the treatment of peritoneal mesothelioma, researchers examined the effects of Bromelain (cysteine proteinase) effects on Mucin 1 (MUC1), a glycosylation-dependent protein that confers tumors with invasiveness, metastasis, and chemoresistance.
In the study in which researchers compared the efficacy of the application of various concentrations of bromelain after 4 and 72 h and combinations of bromelain and cytotoxic drugs (cisplatin or 5-FU) at 72 h, MUC1-expressing MPM cell lines found that bromelain increased the cytotoxicity of cisplatin significantly in cell lines.
Compared to the aforementioned inhibition, combining fluorouracil with bromelain did not show a significant increase in cytotoxicity.
In other words, bromelain improves chemotherapy depending totally on the types of drugs used for the treatment of peritoneal mesothelioma.
Furthermore, bromelain used alone also showed a significant effect in inducing cell death by apoptosis and autophagy.
On pancreatic and breast cancer cells, injection of bromelain also adversely affected the viability of MUC1 expressing on both cell lines.
Based on the findings, Bromelain used alone or combined with other chemo drugs might have a strong effect on the barrier function of MUC1.
Collectively, bromelain inhibited the progression and proliferation of peritoneal mesothelioma by blocking the activity of gene MUC1.
Dr. Pillai K, the lead scientist said, "Current evidence indicates that bromelain may have the potential of being developed into an effective anticancer agent for MPM".
Taken altogether, bromelain may be considered a supplement for the prevention and treatment of peritoneal mesothelioma, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anticancer effect of bromelain with and without cisplatin or 5-FU on malignant peritoneal mesothelioma cells by Pillai K1, Ehteda A, Akhter J, Chua TC, Morris DL. (PubMed)
(2) Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma by Pillai K1, Akhter J, Chua TC, Morris DL. (PubMed)
(3) Asbestos-induced peritoneal mesothelioma in a construction worker by Rodolfo Fonte, Salvatore Gambettino, Mario Melazzini, Mario Scelsi, Claudio Zanon, andStefano M Candura. (PMC)
#Betanin Protects the Liver Against Toxicity Through Its #Antioxidant Activities, Scientists Find
By Kyle J. Norton
Scientists may have found a bioactive ingredient for the treatment of liver toxicity with no side effects, according to studies.
Acute liver toxicity is a condition characterized by the harmful effects of a substance or organism induced by a single or short-term exposure.
Liver toxicity, on the other hand, is caused by long-term exposure to a substance or substances, including alcohol inducing the destruction and interruption of liver tissue regeneration, leading to fibrosis and cirrhosis.
The liver is the largest internal organ with self-regenerative properties. It only plays an essential role in the production of bile to aid digestive functioning, but also filters out blood from the digestive system before passing them back to the heart and other parts of the body.
The most common chronic liver diseases in the Western world are non-alcoholic fatty liver disease (NAFLD) and hepatitis C infection.
According to statistics, NAFLD affects 75 to 100 million Americans in 2017. Approximately 80% of obese and 20% of normal-weight people have NAFLD.
Believe it or not, nearly 2.4 million Americans or 1 percent of the adult population were living with hepatitis C.
The most common cause of acute liver toxicity is Acetaminophen overdose in the United States, leading to acute liver failure.
Dr. Flores YN, the lead scientist in the examination of risk factors for liver disease among Mexican adults in the US and Mexico wrote, "Excessive alcohol consumption is a risk factor for liver disease, but only 60% correctly identified hepatitis C, being overweight or obese, or having diabetes as risk factors".
And, " Identifying the specific risk factors, levels of knowledge, and prevention activities that affect specific racial/ethnic populations is important in order to effectively target efforts to prevent liver disease".
Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a natural compound for the protection of the liver against toxicity, researchers examined the betanin (a natural pigment) mitigated effect in Organophosphates (OP)-induced hepatotoxicity in primary rat hepatocytes.
Administration of betanin (25μM) significantly increased liver cell viability, inhibited the expression of ROS formation and LPO and restored cellular antioxidant levels.
When it was used alone, betanin protected the liver against OPs-induced hepatotoxicity through inhibition of oxidative stress and mitochondrial protection against inflammation.
In order to reveal more information about betanin (from natural pigments) anti-oxidant properties against paraquat-induced liver injury in an animal model.
The study included rats randomly divided into four groups: a control group, a paraquat group, and two groups that received betanin at doses of 25 and 100mg/kg/day three days before and two days after they were administered paraquat.
Paraquat-induced liver toxicity in Sprague-Dawley rats without treatment of betanin showed significant liver toxicity observed by elevated serum aspartate aminotransferase and alanine aminotransferase levels and an increase of enzyme associated with phase I drug metabolism reactions.
In other words, the injection of paraquat led to an unbalanced ratio of free radicals and deleted antioxidant enzymes produced by the host evidenced by levels of oxidative stress.
Injection of betanin not only inhibited the historical change and the aforementioned conditions, but the phytochemical also protected the liver cells against mitochondrial damage and apoptosis-inducing factor protein levels.
Dr. Han J, the lead scientist based on the finding wrote in the final report, "Betanin had a protective effect against paraquat-induced liver damage in rats. The mechanism of the protection appears to be the inhibition of CYP 3A2 expression and protection of mitochondria".
Taken altogether, betanin may be considered a supplement for the treatment of acute liver toxicity, pending the confirmation of the larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin reduces organophosphate-induced cytotoxicity in primary hepatocytes via an anti-oxidative and mitochondrial-dependent pathway by Ahmadian E1, Khosroushahi AY2, Eghbal MA3, Eftekhari A. (PubMed)
(2) Betanin attenuates paraquat-induced liver toxicity through a mitochondrial pathway by Han J1, Zhang Z2, Yang S2, Wang J2, Yang X2, Tan D. (PubMed)
(3) Risk factors for liver disease and associated knowledge and practices among Mexican adults in the US and Mexico by Flores YN1, Lang CM, Salmerón J, Bastani R. (PubMed)
Scientists may have found a bioactive ingredient for the treatment of liver toxicity with no side effects, according to studies.
Acute liver toxicity is a condition characterized by the harmful effects of a substance or organism induced by a single or short-term exposure.
Liver toxicity, on the other hand, is caused by long-term exposure to a substance or substances, including alcohol inducing the destruction and interruption of liver tissue regeneration, leading to fibrosis and cirrhosis.
The liver is the largest internal organ with self-regenerative properties. It only plays an essential role in the production of bile to aid digestive functioning, but also filters out blood from the digestive system before passing them back to the heart and other parts of the body.
The most common chronic liver diseases in the Western world are non-alcoholic fatty liver disease (NAFLD) and hepatitis C infection.
According to statistics, NAFLD affects 75 to 100 million Americans in 2017. Approximately 80% of obese and 20% of normal-weight people have NAFLD.
Believe it or not, nearly 2.4 million Americans or 1 percent of the adult population were living with hepatitis C.
The most common cause of acute liver toxicity is Acetaminophen overdose in the United States, leading to acute liver failure.
Dr. Flores YN, the lead scientist in the examination of risk factors for liver disease among Mexican adults in the US and Mexico wrote, "Excessive alcohol consumption is a risk factor for liver disease, but only 60% correctly identified hepatitis C, being overweight or obese, or having diabetes as risk factors".
And, " Identifying the specific risk factors, levels of knowledge, and prevention activities that affect specific racial/ethnic populations is important in order to effectively target efforts to prevent liver disease".
Betanin is phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
With an aim to find a natural compound for the protection of the liver against toxicity, researchers examined the betanin (a natural pigment) mitigated effect in Organophosphates (OP)-induced hepatotoxicity in primary rat hepatocytes.
Administration of betanin (25μM) significantly increased liver cell viability, inhibited the expression of ROS formation and LPO and restored cellular antioxidant levels.
When it was used alone, betanin protected the liver against OPs-induced hepatotoxicity through inhibition of oxidative stress and mitochondrial protection against inflammation.
In order to reveal more information about betanin (from natural pigments) anti-oxidant properties against paraquat-induced liver injury in an animal model.
The study included rats randomly divided into four groups: a control group, a paraquat group, and two groups that received betanin at doses of 25 and 100mg/kg/day three days before and two days after they were administered paraquat.
Paraquat-induced liver toxicity in Sprague-Dawley rats without treatment of betanin showed significant liver toxicity observed by elevated serum aspartate aminotransferase and alanine aminotransferase levels and an increase of enzyme associated with phase I drug metabolism reactions.
In other words, the injection of paraquat led to an unbalanced ratio of free radicals and deleted antioxidant enzymes produced by the host evidenced by levels of oxidative stress.
Injection of betanin not only inhibited the historical change and the aforementioned conditions, but the phytochemical also protected the liver cells against mitochondrial damage and apoptosis-inducing factor protein levels.
Dr. Han J, the lead scientist based on the finding wrote in the final report, "Betanin had a protective effect against paraquat-induced liver damage in rats. The mechanism of the protection appears to be the inhibition of CYP 3A2 expression and protection of mitochondria".
Taken altogether, betanin may be considered a supplement for the treatment of acute liver toxicity, pending the confirmation of the larger sample size and multicenter human study.
Intake of betanin in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betanin reduces organophosphate-induced cytotoxicity in primary hepatocytes via an anti-oxidative and mitochondrial-dependent pathway by Ahmadian E1, Khosroushahi AY2, Eghbal MA3, Eftekhari A. (PubMed)
(2) Betanin attenuates paraquat-induced liver toxicity through a mitochondrial pathway by Han J1, Zhang Z2, Yang S2, Wang J2, Yang X2, Tan D. (PubMed)
(3) Risk factors for liver disease and associated knowledge and practices among Mexican adults in the US and Mexico by Flores YN1, Lang CM, Salmerón J, Bastani R. (PubMed)
#Antioxidant #Indicaxanthins Exert Protective Effects Against #Atherogenesis Toxicity, According to Studies
By Kyle J. Norton
An atheroma, or atheromatous plaque ("plaque"), is an abnormal accumulation of plaque in the inner layer of the wall of an artery, found in most adults, a leading cause of atherosclerosis.
Atherosclerosis is a condition caused by long-term plaques built-up on the wall of the arteries, leading to narrowing the arteries, a major cause of the cardiovascular disease (CVD)
CVD is a medical condition involved in blood vessels. CVD can be heart disease or stroke depending on the location of a blood clot which causes blockage of the blood flow in the artery.
According to the statistics provided by the Europeanean Hear Network, cardiovascular disease (CVD) causes 3.9 million deaths in Europe and over 1.8 million deaths in the European Union (EU) every year. In 2015, approximately, 11.3 million new cases of CVD in Europe and 6.1 million new cases of CVD in the EU were diagnosed.
Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood.
Atheromatous plaques build-up in the arteries can be classified into several stages, including
* Stage 1 is the foam cells of macrophage and fatty deposits are localized on blood vessel walls.
* Stage 2 Type II is various thread-like fibers or filaments accumulated on the arterial wall.
* Stage 3 is connective tissue deposition on the arteries is thicker.
Stage 1-3 is most frequently found in patients with hypertension, diabetes mellitus, hypercholesterolemia, and who smoke.
* stages 4 and 5 Type IV and V are conditions that the softer plaque with a thinner fibrous cap containing macrophages and smooth muscle cells are formed.
Atherosclerosis at the early stage is asymptomatic. However, in stages 4 and 5, patients may experience symptoms of chest pain, pain in their legs, and arms, particularly in the area of a blocked artery, shortness of breath, fatigue muscle weakness due to reduce blood flow in the arteries.
Indicaxanthin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.
In finding a potent compound for treating atheromas, 7-Ketocholesterol (7-KC)-induced apoptosis of macrophages is considered a key event in the development of human atheromas.
In human atheromatous plaque-induced by the 7-Ketocholesterol (7-KC), researchers found that* The induction of atheromatous plaque within 24 h of injection of 7-KC was associated with the induced cytotoxicity by elevating the expression of intracellular reactive oxygen species over basal levels.
* Furthermore, levels of preceding NADPH oxidase-4 (NOX-4) over-expression and elevation of cytosolic Ca²⁺ associated with an imbalanced ratio of free radicals and antioxidants were also induced by the administration of 7-KC.
* Moreover, the progressive depletion of total thiols that cause oxidative stress was also promoted by the 7-KC
* Additionally, the redox-sensitive NF-κB involved in the inhibition of oxidation was also de-promoted by 7-KC activation.
* Co-incubation of 2·5 μm of Ind not only completely prevented 7-KC-induced pro-apoptosis in the tested cells but also decreased the parameters that lead to the risk of atheromas.
Based on the findings, researchers said, "( Indicaxanthin( a highly bioavailable dietary phytochemical, may exert protective effects against atherogenesis toxicity of 7-KC at a concentration of nutritional interest".
Taken altogether, indicaxanthin may be considered a remedy for the prevention and treatment of atheromas, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phytochemical indicaxanthin suppresses 7-ketocholesterol-induced THP-1 cell apoptosis by preventing cytosolic Ca(2+) increase and oxidative stress by Tesoriere L1, Attanzio A, Allegra M, Gentile C, Livrea MA. (PubMed)
An atheroma, or atheromatous plaque ("plaque"), is an abnormal accumulation of plaque in the inner layer of the wall of an artery, found in most adults, a leading cause of atherosclerosis.
Atherosclerosis is a condition caused by long-term plaques built-up on the wall of the arteries, leading to narrowing the arteries, a major cause of the cardiovascular disease (CVD)
CVD is a medical condition involved in blood vessels. CVD can be heart disease or stroke depending on the location of a blood clot which causes blockage of the blood flow in the artery.
According to the statistics provided by the Europeanean Hear Network, cardiovascular disease (CVD) causes 3.9 million deaths in Europe and over 1.8 million deaths in the European Union (EU) every year. In 2015, approximately, 11.3 million new cases of CVD in Europe and 6.1 million new cases of CVD in the EU were diagnosed.
Plaque is made up of fat, cholesterol, calcium, and other substances found in the blood.
Atheromatous plaques build-up in the arteries can be classified into several stages, including
* Stage 1 is the foam cells of macrophage and fatty deposits are localized on blood vessel walls.
* Stage 2 Type II is various thread-like fibers or filaments accumulated on the arterial wall.
* Stage 3 is connective tissue deposition on the arteries is thicker.
Stage 1-3 is most frequently found in patients with hypertension, diabetes mellitus, hypercholesterolemia, and who smoke.
* stages 4 and 5 Type IV and V are conditions that the softer plaque with a thinner fibrous cap containing macrophages and smooth muscle cells are formed.
Atherosclerosis at the early stage is asymptomatic. However, in stages 4 and 5, patients may experience symptoms of chest pain, pain in their legs, and arms, particularly in the area of a blocked artery, shortness of breath, fatigue muscle weakness due to reduce blood flow in the arteries.
Indicaxanthin is a phytochemical in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains found abundantly in beets, chard, etc.
In finding a potent compound for treating atheromas, 7-Ketocholesterol (7-KC)-induced apoptosis of macrophages is considered a key event in the development of human atheromas.
In human atheromatous plaque-induced by the 7-Ketocholesterol (7-KC), researchers found that* The induction of atheromatous plaque within 24 h of injection of 7-KC was associated with the induced cytotoxicity by elevating the expression of intracellular reactive oxygen species over basal levels.
* Furthermore, levels of preceding NADPH oxidase-4 (NOX-4) over-expression and elevation of cytosolic Ca²⁺ associated with an imbalanced ratio of free radicals and antioxidants were also induced by the administration of 7-KC.
* Moreover, the progressive depletion of total thiols that cause oxidative stress was also promoted by the 7-KC
* Additionally, the redox-sensitive NF-κB involved in the inhibition of oxidation was also de-promoted by 7-KC activation.
* Co-incubation of 2·5 μm of Ind not only completely prevented 7-KC-induced pro-apoptosis in the tested cells but also decreased the parameters that lead to the risk of atheromas.
Based on the findings, researchers said, "( Indicaxanthin( a highly bioavailable dietary phytochemical, may exert protective effects against atherogenesis toxicity of 7-KC at a concentration of nutritional interest".
Taken altogether, indicaxanthin may be considered a remedy for the prevention and treatment of atheromas, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phytochemical indicaxanthin suppresses 7-ketocholesterol-induced THP-1 cell apoptosis by preventing cytosolic Ca(2+) increase and oxidative stress by Tesoriere L1, Attanzio A, Allegra M, Gentile C, Livrea MA. (PubMed)
#Cucurbitacin B isolated from Cucumber Processes Anti-#LaryngealCancer Properties in Vitros, Researchers Suggest
By Kyle J. Norton
Laryngeal cancer is a medical condition characterized by abnormal cell growth in the tissues of the larynx due to the alternation of cell DNA.
Moreover, Hep-2 cell lines treated with the cucurbitacin B/cisplatin combination demonstrated a significantly reduced level of p-Stat3, compared to single-agent treated cells.
Where overexpression of p-STAT3 is an indication of a poor prognosis biomarker in cancer.
Additionally, cucurbitacin B/cisplatin-treated Hep-2 cells also demonstrated a significant reduction of the protein associated with regulation in the cell cycle and anti-apoptosis, compared to single-agent cucurbitacin B or cisplatin-treated cells.
Based on the results, researchers said, "These results suggest that the cucurbitacin B/cisplatin combination treatment may be a potentially useful therapeutic option for individuals diagnosed with laryngeal cancer".
In order to reveal more information about cucumber's anti-laryngeal cancer properties, scientists evaluated the combined antitumor effect of cucurbitacin B with docetaxel on Hep-2, a human laryngeal cancer cell line.
The combination of cucurbitacin B and docetaxel produced greater efficacy in growth inhibition, cell cycle arrest at the G2/M phase, and apoptosis induction similar to those of the aforementioned study compared to single-agent treatment.
The efficacy of the combined effect of cucurbitacin B and docetaxel anti-Hep-2 was attributed to the suppression of the expression of proteins involved in tumor proliferation and migration.
In vivo, the combination of cucurbitacin B with docetaxel also synergistically inhibited tumor growth in a mouse xenograft model.
Taken altogether, cucumber processed with a high amount of cucurbitacin B may be considered supplements combined with conventional medicine for the treatment of laryngeal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of cucurbitacin B in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin by Liu T1, Peng H, Zhang M, Deng Y, Wu Z. (PubMed)
(2) Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer by Liu T1, Zhang M, Zhang H, Sun C, Yang X, Deng Y, Ji W. (PubMed)
(3) Cessation of smoking and drinking and the risk of laryngeal cancer by A Altieri,1 C Bosetti,1 R Talamini,2 S Gallus,1 S Franceschi,3 F Levi,4 L Dal Maso,2 E Negri,1and C La Vecchia. (PMC)
Laryngeal cancer is a medical condition characterized by abnormal cell growth in the tissues of the larynx due to the alternation of cell DNA.
Larynx, also known as the voice box is a tube above the windpipe (trachea) in the neck and in front of the food pipe.
Most cases of laryngeal cancer start in the cell on the surface of the inner lining of the larynx, before penetrating into the deeper layers to form a tumor.
At the very early of cell alternation, patients are asymptomatic. However, as the tumor continues to grow, the cancer cell may infect other healthy tissues a distance away through the blood and fluids distribution.
Laryngeal cancer shares the general symptoms with other cancer including unintended pain, weight loss, loss of appetite, fatigue, and gastrointestinal discomforts accompanied by specific symptoms of a lump or swelling in your neck. a long-lasting cough, a persistent sore throat or earache, and difficulty breathing. in severe cases.
Sometimes, patients may vomit blood due to the oversize tumor which has pressed on the nearby blood vessels.
Out of many prevalent risk factors, smoking tobacco (cigarettes, pipes, cigars) is considered a major culprit that increases the risk of developing laryngeal cancer in the Western world.
Dr. A Altieri, the lead scientist wrote, "Cancer of the larynx is extremely rare in individuals who neither smoke nor drink alcohol (Austin and Reynolds, 1996). The risk rises with increasing levels of smoking and drinking, each agent approximately multiplying the effects of the other (Elwood et al, 1984; Blot, 1992; Dosemeci et al, 1997; Talamini et al, 2002). The risk of laryngeal cancer is 10–20-fold higher in current smokers than in non-smokers".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find potential and natural chemotherapy for the treatment of laryngeal cancer, researchers examined whether cucurbitacin B can also enhance the sensitivity of Hep-2 laryngeal cells to cisplatin.
The study included the evaluation of the proliferation, cell cycle distribution, and apoptosis in Hep-2 cells treated with either cucurbitacin B, cisplatin, or a combination.
According to the tested results, Hep-2 cells treated with a cucurbitacin B/cisplatin combination display synergistic effects on growth inhibition, cell cycle arrest, and apoptosis induction, compared to single-agent cucurbitacin B or cisplatin-treated cells.
Most cases of laryngeal cancer start in the cell on the surface of the inner lining of the larynx, before penetrating into the deeper layers to form a tumor.
At the very early of cell alternation, patients are asymptomatic. However, as the tumor continues to grow, the cancer cell may infect other healthy tissues a distance away through the blood and fluids distribution.
Laryngeal cancer shares the general symptoms with other cancer including unintended pain, weight loss, loss of appetite, fatigue, and gastrointestinal discomforts accompanied by specific symptoms of a lump or swelling in your neck. a long-lasting cough, a persistent sore throat or earache, and difficulty breathing. in severe cases.
Sometimes, patients may vomit blood due to the oversize tumor which has pressed on the nearby blood vessels.
Out of many prevalent risk factors, smoking tobacco (cigarettes, pipes, cigars) is considered a major culprit that increases the risk of developing laryngeal cancer in the Western world.
Dr. A Altieri, the lead scientist wrote, "Cancer of the larynx is extremely rare in individuals who neither smoke nor drink alcohol (Austin and Reynolds, 1996). The risk rises with increasing levels of smoking and drinking, each agent approximately multiplying the effects of the other (Elwood et al, 1984; Blot, 1992; Dosemeci et al, 1997; Talamini et al, 2002). The risk of laryngeal cancer is 10–20-fold higher in current smokers than in non-smokers".
The cucumber plant is a species of Cucumis Sativus, belongs to the family Cucurbitaceae, and is native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find potential and natural chemotherapy for the treatment of laryngeal cancer, researchers examined whether cucurbitacin B can also enhance the sensitivity of Hep-2 laryngeal cells to cisplatin.
The study included the evaluation of the proliferation, cell cycle distribution, and apoptosis in Hep-2 cells treated with either cucurbitacin B, cisplatin, or a combination.
According to the tested results, Hep-2 cells treated with a cucurbitacin B/cisplatin combination display synergistic effects on growth inhibition, cell cycle arrest, and apoptosis induction, compared to single-agent cucurbitacin B or cisplatin-treated cells.
Moreover, Hep-2 cell lines treated with the cucurbitacin B/cisplatin combination demonstrated a significantly reduced level of p-Stat3, compared to single-agent treated cells.
Where overexpression of p-STAT3 is an indication of a poor prognosis biomarker in cancer.
Additionally, cucurbitacin B/cisplatin-treated Hep-2 cells also demonstrated a significant reduction of the protein associated with regulation in the cell cycle and anti-apoptosis, compared to single-agent cucurbitacin B or cisplatin-treated cells.
Based on the results, researchers said, "These results suggest that the cucurbitacin B/cisplatin combination treatment may be a potentially useful therapeutic option for individuals diagnosed with laryngeal cancer".
In order to reveal more information about cucumber's anti-laryngeal cancer properties, scientists evaluated the combined antitumor effect of cucurbitacin B with docetaxel on Hep-2, a human laryngeal cancer cell line.
The combination of cucurbitacin B and docetaxel produced greater efficacy in growth inhibition, cell cycle arrest at the G2/M phase, and apoptosis induction similar to those of the aforementioned study compared to single-agent treatment.
The efficacy of the combined effect of cucurbitacin B and docetaxel anti-Hep-2 was attributed to the suppression of the expression of proteins involved in tumor proliferation and migration.
In vivo, the combination of cucurbitacin B with docetaxel also synergistically inhibited tumor growth in a mouse xenograft model.
Taken altogether, cucumber processed with a high amount of cucurbitacin B may be considered supplements combined with conventional medicine for the treatment of laryngeal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of cucurbitacin B in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin by Liu T1, Peng H, Zhang M, Deng Y, Wu Z. (PubMed)
(2) Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer by Liu T1, Zhang M, Zhang H, Sun C, Yang X, Deng Y, Ji W. (PubMed)
(3) Cessation of smoking and drinking and the risk of laryngeal cancer by A Altieri,1 C Bosetti,1 R Talamini,2 S Gallus,1 S Franceschi,3 F Levi,4 L Dal Maso,2 E Negri,1and C La Vecchia. (PMC)
#Healthyfood #CruciferousVegetables in Reducing the Risk of Inflammation in Adult with Gene GSTT1, According to Studies
By Kyle J. Norton
Inflammation is a natural expression by the immune system in the induction of white blood cells to protect our body against infection with foreign organisms,
Cruciferous vegetables are a group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.
In a randomized controlled trial in healthy young adults, isothiocyanates found in cruciferous vegetables exhibited anti-inflammatory effects through altered serum concentrations of interleukin (IL)-6, IL-8, C-reactive protein (CRP)), in increased increases in the presence of inflammation in the body tumor, and necrosis factor (TNF) α,, involved in systemic inflammation.
Intake of Cruciferous Vegetables has been shown to reduce the circulation of proinflammatory cytokines, namely IL-6 through inhibiting the expression of an abnormal function of gene Glutathione S-Transferase Theta 1(GSTT1) metabolism in lower levels of glutathione, the antioxidant with anti-inflammatory properties.
Dr. Navarro SL, the lead researcher said, " IL-6 concentrations were significantly lower on day 14 of (the double-dose cruciferous) (2xC) and (cruciferous plus apiaceous (carrot family) 1xC+A diets than with the basal diet,...respectively]" and " Twenty-four-hour urinary isothiocyanate excretion was not associated with any of the inflammation markers overall; however, IL-6 was inversely associated with total isothiocyanate excretion in GSTM1".
In support of the above study, isothiocyanates (ITC) from cruciferous vegetables showed to increase levels of serum of Glutathione S-transferases (GST), the enzymes that detoxify a broad range of free radicals in reduced risk of inflammation, particularly in GSTM1-null women.
Furthermore, the phytochemical also increased GSTA1/2, the antioxidant enzyme in GSTM1-null/GSTT1-null men.
Taking it all together, the intake of Cruciferous Vegetables regularly is associated to lower the effect of proinflammatory cytokines, particularly in adults with gene GSTT1.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults by Navarro SL1, Schwarz Y2, Song X2, Wang CY2, Chen C2, Trudo SP3, Kristal AR2, Kratz M2, Eaton DL4, Lampe JW2. (PubMed)
(2) Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes by Navarro SL1, Chang JL, Peterson S, Chen C, King IB, Schwarz Y, Li SS, Li L, Potter JD, Lampe JW. (PubMed)
Inflammation is a natural expression by the immune system in the induction of white blood cells to protect our body against infection with foreign organisms,
Cruciferous vegetables are a group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.
In a randomized controlled trial in healthy young adults, isothiocyanates found in cruciferous vegetables exhibited anti-inflammatory effects through altered serum concentrations of interleukin (IL)-6, IL-8, C-reactive protein (CRP)), in increased increases in the presence of inflammation in the body tumor, and necrosis factor (TNF) α,, involved in systemic inflammation.
Intake of Cruciferous Vegetables has been shown to reduce the circulation of proinflammatory cytokines, namely IL-6 through inhibiting the expression of an abnormal function of gene Glutathione S-Transferase Theta 1(GSTT1) metabolism in lower levels of glutathione, the antioxidant with anti-inflammatory properties.
Dr. Navarro SL, the lead researcher said, " IL-6 concentrations were significantly lower on day 14 of (the double-dose cruciferous) (2xC) and (cruciferous plus apiaceous (carrot family) 1xC+A diets than with the basal diet,...respectively]" and " Twenty-four-hour urinary isothiocyanate excretion was not associated with any of the inflammation markers overall; however, IL-6 was inversely associated with total isothiocyanate excretion in GSTM1".
In support of the above study, isothiocyanates (ITC) from cruciferous vegetables showed to increase levels of serum of Glutathione S-transferases (GST), the enzymes that detoxify a broad range of free radicals in reduced risk of inflammation, particularly in GSTM1-null women.
Furthermore, the phytochemical also increased GSTA1/2, the antioxidant enzyme in GSTM1-null/GSTT1-null men.
Taking it all together, the intake of Cruciferous Vegetables regularly is associated to lower the effect of proinflammatory cytokines, particularly in adults with gene GSTT1.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults by Navarro SL1, Schwarz Y2, Song X2, Wang CY2, Chen C2, Trudo SP3, Kristal AR2, Kratz M2, Eaton DL4, Lampe JW2. (PubMed)
(2) Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypes by Navarro SL1, Chang JL, Peterson S, Chen C, King IB, Schwarz Y, Li SS, Li L, Potter JD, Lampe JW. (PubMed)
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