#Phytochemical #Piperine in the Inhibition of the Onset of #Breastcancer and #LungCancer in Vitros, Researchers Find

By Kyle J. Norton

Piperine may be the new source of phytochemicals used for the prevention and treatment of breast cancer, some studies suggested.
Breast cancer is a medical condition caused by the alternation of DNA of cells in the breast tissue.

According to the statistic, in 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Most cases of breast cancer start with cell growth disorderly on the surface of the inner lining of the breast tissue. However, at the later stage, malignant cells can infect other healthy cells and tissue far way from the breast through fluids and blood circulation.

The exact causes of breast cancer are unknown. However, the genetic prepositions that link to the breast cancer onset have been under intensive study over the last few decades.

Women who inherited the mutated gene BRCA 1 and 2 are associated with over 60% of breast cancer risk compared to women who do not.
Another risk factor associated with breast cancer risk has been mentioned in the scientific community
are a diet high in saturated and trans fat, red meat and processed foods and low in fruits and vegetables.

Dr. Stoll BA on the Oncology Department, St. Thomas' Hospital, in the study "Breast cancer and the western diet, the role of fatty acids and antioxidant vitamins" said, "An increased ratio of n-3 to n-6 polyunsaturated fatty acids (PUFAs) in the diet inhibits the growth of the rat mammary cancer model" and " There is also evidence that members of then-3 PUFA series can inhibit the growth of human breast cancer cells both in vitro and in explants".

" Clinical trials of supplementary n-3 PUFAs in conjunction with a reduced fat intake have been proposed for breast cancer prevention".

These results suggested women who reduce the intake of saturated and trans fat, red meat, and processed food and replace them with foods that processed a high amount of polyunsaturated fatty acids and antioxidants such as fruits and vegetables are at a reduced risk of breast cancer.

Piperine is a phytochemical alkaloid in the class of organosulfur compounds, found abundantly in white and black pepper, long pepper, etc.

Dr. Do MT and colleagues in the cancer programs at the Chungnam National University, in the finding a natural compound for treatment of genetic mutation that causes breast cancer launched an investigation to examine the effect of Piperine, a bioactive component of black pepper, Piper nigrum Linn, molecular mechanisms by which piperine exerts antitumor effects in HER2-overexpressing breast cancer cells.

In HER2-overexpressing breast cancer cells, piperine strongly inhibited proliferation and induced apoptosis through caspase-3 activation and PARP cleavage, the proteins with the function to program cell death.

Piperine also inhibited HER2 gene expression in the promotion of cancer cell proliferation by blockading ERK1/2 signaling. Piperine significantly reduced levels of SREBP-1 and FAS expression which is associated to promote cancer growth and survival.

Further analysis suggested that piperine suppressed the growth of tumors through stimulating the protein in the induction of cell apoptosis and inhibiting the protein in the promotion of cell proliferation and survival.

Dr.Do MT. in the final report of the study said, "Piperine may be a potential agent for the prevention and treatment of human breast cancer with HER2 overexpression".

Moreover, in the study of piperine on the tumor growth and metastasis of mouse 4T1 mammary carcinoma in vitro and in vivo, researchers showed that application of Piperine (35-280 μmol/L) inhibits the growth of 4T1 cells in time- and dose-dependent manners (the IC(50) values were 105 ± 1.08 and 78.52 ± 1.06 μmol/L, respectively, at 48 and 72 h).

Piperine (70-280 μmol/L) dose-dependently induced apoptosis of 4T1 cells through the proteins that program cell death.

Piperine (140 and 280 μmol/L) significantly increased the percentage of cells in G(2)/M phase before inducing apoptosis with a reduction in the expression of cyclin B1 in facilitating the cell proliferation.

Additionally, Piperine (140 and 280 μmol/L) significantly decreased the expression of MMP-9 and MMP-13 in promoting the cancer cell division and survival and inhibited 4T1 cell migration in vitro.

At the final phase of the experiment, researchers also discovered that injection of piperine (2.5 and 5 mg/kg) dose-dependently suppressed the primary 4T1 tumor growth and injection of piperine (5 mg/kg) significantly inhibited the lung metastasis.

Taken altogether, piperine, a major pungent alkaloid present in pepper family may be considered functional phytochemical for the prevention and combined with the primary therapy for the treatment of breast cancer, depending to large sample size and multicenter human study

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References

(I) Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells by Do MT, Kim HG, Choi JH, Khanal T, Park BH, Tran TP, Jeong TC, Jeong HG. (PubMed)

(2) Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model by Lai LH, Fu QH, Liu Y, Jiang K, Guo QM, Chen QY, Yan B, Wang QQ, Shen JG.(PubMed)

(3) Breast cancer and the western diet: role of fatty acids and antioxidant vitamins by Stoll BA. (PubMed)

#Antioxidant #Sulforaphanes Process Anti-#Obesity Properties, According to Researchers

By Kyle J. Norton

Dithiolthiones, a bioactive ingredient found in cruciferous vegetables may have an effect on reducing the risk of obesity in chronic consumption, some scientists suggested.
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

Obesity is a medical condition caused by excess body fat accumulated over time.

And, overweight is a condition of excess body weight relative to height.

According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity.

According to the statistic, 68% of the American population is either overweight or obese.

Some researchers suggested that the prevalent and widespread obesity in the Western world not only increased the burden of health care and economic cost but also induce a reduced quality of life of adults due to chronic ailments.

In the comparison of the obesity rate today and 50 years ago, the Centers for Disease Control statistic showed that the obesity rate has skyrocketed by more than 185 percent among American adults over the last 50 years, and the rate of extreme obesity among children have tripled during the same time period.

These results clearly suggested that adults today must have something different in their daily activities that contributes to these significant changes.

Some researchers suggested that lack of exercise may be one of the most prevalent risk factors which induce the onset of obesity.

Dr. Petri, the lead scientist in the examine the role of physical activity and exercise in obesity and weight said, "Obesity is caused by a consistent decline in daily energy expenditure is not supported either by objective measures of energy expenditure or physiological theory of weight gain alone. However, since voluntary exercise is the most important discretionary component of total daily energy expenditure, it can affect energy balance".

This conclusion indicated that lack of exercise and over-nutrient consumption work together to facilitate the onset of overweight and obesity.

In the concern of obesity widespread in the American population, researchers examine the anti-obesity effect of sulforaphane in the animal model. C57BL/6N mice in the study. were fed a normal diet (ND), HFD, or HFD plus 0.1% sulforaphane (SFN) for 6 weeks.

According to the food efficiency ratios compared to the untreated control, the sulforaphane treatment group showed a lower body weight. SFN attenuated HFD-induced visceral adiposity, adipocyte hypertrophy associated with increasing the store of fat within the abdominal cavity, and fat accumulation in the liver.

Furthermore, Serum total cholesterol and leptin, and liver triglyceride levels were lower in HFD-SFN-fed mice than in HFD-fed mice.


The efficacy of SFN in the anti-fat deposit was attributed to the decreased expression of a protein that plays critical in reducing triglyceride levels and regulating energy homeostasis and increased adiponectin expression in the modulation of glucose and fatty acid oxidation.
Taking foods containing sulforaphane may be effective in managing weight loss for obese patients accompanied by a change of lifestyle with more vegetables and fruits into a diet.

In a highly palatable (HP) diet of male Wistar rats, injection of sulforaphane (SFN, 1 mg kg⁻¹, 4 months treatment)exerted some beneficial effects on obesity and insulin resistance.

Moreover, glucose tolerance was lower in the HP diet groups, especially in the HP group treated with SFN. Except for the liver triacylglycerols.

Moreover, SFN at the specific dose was found to accentuate glucose intolerance and affect the GLUT3 protein in facilitating the transport of glucose across the plasma membranes of mammalian cells in the cerebral cortex and hypothalamus in the HP diet group treated with SFN.

Taken altogether, plant base sulforaphane may be considered a bioactive compound for the prevention and treatment of obesity with no side effects


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice by Choi KM1, Lee YS1, Kim W1, Kim SJ2, Shin KO1, Yu JY3, Lee MK1, Lee YM1, Hong JT1, Yun YP1, Yoo HS4. (PubMed)
(2) Chronic sulforaphane oral treatment accentuates blood glucose impairment and may affect GLUT3 expression in the cerebral cortex and hypothalamus of rats fed with a highly palatable diet by Souza CG1, Riboldi BP, Hansen F, Moreira JD, Souza DG, de Assis AM, Brum LM, Perry ML, Souza DO. (PubMed)
(3) Sulforaphane induced adipolysis via hormone-sensitive lipase activation, regulated by AMPK signaling pathway by Lee JH1, Moon MH, Jeong JK, Park YG, Lee YJ, Seol JW, Park SY. (PubMed)
(4) The role of physical activity and exercise in obesity and weight management: Time for critical appraisal by PetriWiklund. (Research Gate)

#Herbal #Chickweed Inhibits Hepatitis and the Levels of #Hepatitis DNA in Vitros, Researchers Show

By Kyle J. Norton

Scientists may have found a single whole herb that processes a significant effect in reducing the risk and treatment of hepatitis with no side effects, some studies suggested.
Hepatitis is a group of infectious diseases characterized by the inflammation of the liver.

Most cases of hepatitis are caused by a viral infection, such as hepatitis A, B, and C. However, the disease also can be induced by excessive alcohol drinking and long-term intake of certain medications such as the popular Nonsteroidal anti-inflammatory drugs (NSAIDs).

Genetic prepositions such as genes and certain medical conditions such as Cryoglobulinemia, a disease with an abnormality of the antibody and B-cell non-Hodgkin's lymphoma are also found to elevate the risk of the disease onset.

Dr. Zheng Zeng in the study "Human genes involved in hepatitis B virus infection", wrote, " There is an approximate 90% risk of becoming a persistent carrier following perinatal infection in infants born to e antigen-positive carrier mothers and a 30% risk in pre-school children. Only 5%-10% of adults become persistent carriers following infection".


Hepatitis is a very contagious disease. people who eat food or drink beverages contaminated with the feces of an infected person are easily infected by the virus.

Fishes and selfishes that grow in polluted water are also found to infect people with the hepatitis virus.

Other risk factors associated with liver inflammation include liver disease, cirrhosis, and toxicity.

According to the investigation of hepatitis infection among 563 adult Swedish expatriates suggested, "The most frequently reported recognized risk factors for the acquisition of viral hepatitis (as reported in a self-administered questionnaire) were having received an inoculation during medical or dental treatment, reported by 45% of all subjects, and having had sexual contact with the indigenous population, reported by 35%" and "the prevalences of hepatitis A virus (HAV) and hepatitis C virus (HCV) markers in these expatriates were of the same magnitude as previously reported in the general Swedish population, 8% and 0.3%, respectively, the prevalence of markers for a past or present HBV infection was about twice as high (5%)".

Chickweed is a cool-season annual plant often eaten by chickens., genus S. media, belonging to the family Caryophyllaceae, native to Europe.

The herb has been used in herbal medicine to treat skin conditions, indigestion, eczema, cough, rashes, etc., and as an astringent, carminative, demulcent, diuretic, expectorant, laxative, refrigerant, vulnerary agent.

In the study to reaffirm the use of Chickweed in traditional Chinese medicine for the treatment of viral infection, researchers at the Jiangsu Provincial Academy of Chinese Medicine conducted an evaluation to examine the anti-hepatitis virus of fresh juice made from the herbal medicine.

All the fresh chickweed juices were prepared with macroporous resin and ultrafiltration technology.

In vitro, the human HBV-transfected liver cell line HepG2.2.15. after treatment with fresh chickweed juices for 6 or 9 days, with the injection of 30 μg/mL SM-3 effectively suppressed the secretion of HBsAg and HBeAg with inhibition rates of 27.92% and 25.35% after 6 days of treatment of HepG2.2.15 cells, respectively.

The application of SM-3 reduced the level of HBV DNA in a dose-dependent manner.

Furthermore, the SM-3 also potentially affected the reduction in HBV antigens.

Moreover, in the examine the characterization and quantitation of the chemical composition of SM-3, researchers discovered that the efficacy of SM-3 in the inhibition of the human HBV-transfected liver cell line HepG2.2.15 was the result of antiviral activities of the presence of flavonoid C-glycosides, polysaccharides, and protein found in the herb.

These results strongly suggested that herbal Chickweed possesses potential anti-HBV activity in vitro.

Additionally, in the examine the anti-hepatoma activity on five human liver-cancer cell lines, i.e. HepG2/C3A, SK-HEP-1, HA22T/VGH, Hep3B and PLC/PRF/5. of 15 15 herbal medicines used as folk medicine in Canada were evaluated by the McGill University.

Chickweed was found to exert a significant effect in protecting the liver against the growth of all five cell lines, HepG2/C3A, SK-HEP-1, HA22T/VGH, Hep3B, and PLC/PRF/5.


Taken altogether, Chickweed may be considered a function of herbal medicine for the prevention and treatment of hepatitis.

However, due to the limitation of the above studies, additional data collection large example size and multi-center studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of Chickweed anti-hepatitis possibilities.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) In vitro anti-hepatoma activity of fifteen natural medicines from Canada by Lin LT1, Liu LT, Chiang LC, Lin CC. (PubMed)(2) Bioactive constituents from Chinese natural medicines. XIV. New glycosides of beta-carboline-type alkaloid, neolignan, and phenylpropanoid from Stellaria dichotoma L. var. lanceolata and their antiallergic activities by Morikawa T1, Sun B, Matsuda H, Wu LJ, Harima S, Yoshikawa M.(PubMed
(3) Anti-hepatitis B virus activity of chickweed [Stellaria media (L.) Vill.] extracts in HepG2.2.15 cells by Ma L1, Song J, Shi Y, Wang C, Chen B, Xie D, Jia X.(PubMed)
(4) Evaluation of the hepatoprotective activity of water-soluble polysaccharide fraction of Stellaria media L. by Gorina YV1, Saprykina EV, Gereng EA, Perevozchikova TV, Krasnov EA, Ivanova EV, Fait EA, Baranova OV. (PubMed)
(5) In vitro anti-hepatoma activity of fifteen natural medicines from Canada by Lin LT1, Liu LT, Chiang LC, Lin CC. (PubMed)

#Herbal #Anise Essential Oils Kills #ColonCancer Cells Through Its Anti #OxidativeStress Activities, Scientists Suggest

By Kyle J. Norton

Anise may have a potential and substantial effect in reduced risk and progression and treatment of colon cancer, some scientists suggested.

Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic,...

Chemical comstituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

In the study of a green synthesis route to produce AgNPs by using an aqueous extract of Pimpinella anisum seeds (3 mM) on human neonatal skin stromal cells (hSSCs) and colon cancer cells (HT115) researchers found that under influence of Anise extract, AgNPs exhibited a strong cytotoxicity effect against hSSC cells and HT115 cells through inhibited the cell proliferation and induced apoptosis, in a dose-dependent manner, according to proliferation tests and cell viability assays.

Further differentiation also suggested that green-synthesized AgNPs exerted a significant effect against five infectious bacteria: Staphylococcus pyogenes (29213), Acinetobacter baumannii (4436), Klebsiella pneumoniae (G455), Salmonella typhi, and Pseudomonas aeruginosa which have been associated to increase risk of colon cancer.

After taking into account other confounders, Dr. Alsalhi MS, the lead author suggested that
P. anisum-synthesized AgNPs as novel and cheap agents for eco-friendly nanosynthetical routes in the treatment of colon cancer.



Moreover, the examine 3 commercially grown native herbs unique to Australia, Tasmannia pepper leaf (Tasmannia lanceolata R. Br., Winteracea; TPL), anise myrtle (Syzygium anisatum Vickery, Craven & Biffen, Myrtaceae; AM) and lemon myrtle (Backhousia citriodora F. Muell, Myrtaceae; LM) as well as a reference sample bay leaf (Laurus nobilis L., Lauraceae; BL), cytoprotective properties in colon adenocarcinoma (HT-29) cells, indicated that Anise demonstrated a potential effect in inhibited colon cancer cell line HT-29 with IC(50) through
increased antioxidant activity in reduced expression of reactive oxygen species in the initiation of cancer cell proliferation.

Additionally, the Application of Anise promoted colon cancer cell death by activating caspase-3 enzyme in enhancing the killer T cell's activity to initiate cancer cells apoptosis by killer T cells.

According to the Cytokinesis-block micronucleus cytometry assay, the application of Anise extract inhibited colon adenocarcinoma (HT-29) cells at concentrations of 0.5 and 1.0mg/ml. without causing harm to the neighbor's healthy cells

The above analysis was supported by the study evaluating the effect of the volatile preparations of essential oils of the Greek plants Ocimum basilicum (sweet basil), Mentha spicata (spearmint), Pimpinella anisum (anise), and Fortunella margarita (kumquat) on the model of human colon carcinoma.

Application of the herbal preparation expressed a significant activity in precipitated cytotoxicity effect in some infectious microorganisms associated with the facilitation of the early stage of colon cancer.

According to the DPPH and ABTS assay, the application of all herbal essential oils also increased the expression of antioxidants in decreased free radical expression in elevated cancer cells in cycle division.


Dr. Fitsiou E, the lead author said, "All essential oil preparations exhibited a variable degree of antiproliferative activity, depending on the cancer model used, with the most potent one being sweet basil against an in vitro model of human colon carcinoma".

The information findings suggested that Anise may be considered a functional herb for reduced risk, progression, and treatment of colon cancer. However, intake of Anise extract should be taken with care as some supplements have been found to induce acute liver toxicity.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.


Sources
(1) Green synthesis of silver nanoparticles using Pimpinella anisum seeds: antimicrobial activity and cytotoxicity on human neonatal skin stromal cells and colon cancer cells by Alsalhi MS1, Devanesan S1, Alfuraydi AA2, Vishnubalaji R3, Munusamy MA2, Murugan K4, Nicoletti M5, Benelli G6.(PubMed)
(2) Cytoprotective and pro-apoptotic activities of native Australian herbs polyphenolic-rich extracts by Sakulnarmrat K1, Fenech M, Thomas P, Konczak I.(PubMed)
(3) Phytochemical Profile and Evaluation of the Biological Activities of Essential Oils Derived from the Greek Aromatic Plant Species Ocimum basilicum, Mentha spicata, Pimpinella anisum and Fortunella margarita by Fitsiou E1, Mitropoulou G2, Spyridopoulou K3, Tiptiri-Kourpeti A4, Vamvakias M5, Bardouki H6, Panayiotidis MΙ7, Galanis A8, Kourkoutas Y9, Chlichlia K10, Pappa A11.(PubMed)

#Healthyfood #Cinnamon in the Management of Diabetes and Its Complications, According to Clinical Studies

By Kyle J. Norton

Cinnamon is a spice derived from the inner bark of a tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the familyLauraceae, use in herbal and traditional medicine as an anti-fungal and bacterial levels, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.

Cinnamaldehyde, in the animal study found in the husk of Cicer arietinum L. Monosaccharide, exhibited antioxidant effects in reduced 29% of free radical expression and glucolipid levels through its action on multiple signaling pathways including cell cycle arrest and anti-pro-inflammatory property.

In vivo and in vitro, administered orally cinnamic acid and cinnamaldehyde lower acute blood glucose and improve glucose tolerance, through stimulating insulin secretion in isolated islets, according to the joint study led by the University of Karachi.

In a 16-week double-blind randomized control trial of 116 individuals with metabolic syndrome, dietary intervention groups with the administration of cinnamon [6 capsules (3 g) daily], significantly improved all components of metabolic syndrome in a sample of Asian Indians in north India.

Dr. Gupta Jain S lead author of the researchers said, "Significantly greater decrease [difference between means, (95% CI)] in fasting blood glucose (mmol/L) [0.3 (0.2, 0.5) p = 0.001], glycosylated haemoglobin (mmol/mol) [2.6 (0.4, 4.9) p = 0.023], waist circumference (cm) [4.8 (1.9, 7.7) p = 0.002] and body mass index (kg/m2 ) [1.3 (0.9, 1.5) p = 0.001] was observed in the cinnamon group compared to placebo group".

Other researchers in the study of cinnamon (Cinnamomum cassia) anti-diabetic property on obese patients also suggested, its effectiveness of increased the lipid storage capacity of white adipocytes and increased the fatty acid oxidation capacity may be due to activities of some other components of cinnamon (Cinnamomum cassia) in the prevention of obesity-induced type II diabetes

Although cinnamon (Cinnamomum sp) has been shown to express reasonable glycemic control to patients with type 2 diabetes mellitus (T2DM), the intake of cinnamon supplements and whole herb should only be given by a qualified herbal doctor to achieve a greater health effect without side effects.

According to traditional Chinese medicine, cinnamon is a very hot herb, overdoses may induce toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma ISSN 0975-6299.

Sources
(1) Chromium and polyphenols from cinnamon improve insulin sensitivity. by Anderson RA1(PubMed)
(2) Cinnamaldehyde in diabetes: A review of pharmacology, pharmacokinetics, and safety by Zhu R1, Liu H1, Liu C2, Wang L1, Ma R1, Chen B1, Li L1, Niu J1, Fu M3, Zhang D4, Gao S5.(PubMed)
(3) Cinnamic acid exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro by Hafizur RM1, Hameed A2, Shukrana M3, Raza SA2, Chishti S2, Kabir N4, Siddiqui RA2.(PubMed)
(4) Effect of oral cinnamon intervention on metabolic profile and body composition of Asian Indians with metabolic syndrome: a randomized double -blind control trial by Gupta Jain S1, Puri S1, Misra A2, Gulati S3,4, Mani K5.(PubMed)
(5) Stimulatory Effects of Cinnamon Extract (Cinnamomum cassia) during the Initiation Stage of 3T3-L1 Adipocyte Differentiation by Lee SG1, Siaw JA2, Kang HW3.(PubMed)

#Healthyfood #Ginger Process #GastroProtective Activities Against the Risk of Gastrointestinal Disorders, Scientists Suggest

By Kyle J. Norton

Scientists may have found a kitchen-pungent spice for the treatment of the gastrointestinal disorder, some studies suggested.
Gastrointestinal diseases are the conditions of the digestive system associated with the disorders involving the gastrointestinal tract, including esophagus, stomach, small intestine, large intestine, and rectum.

The digestive system includes the gastrointestinal tract (GI), liver, pancreas, and gallbladder with a healthy function of breaking down food into nutrients and fluids for the body's need.

There are many different types of gastrointestinal diseases, including irritable bowel syndrome (IBS), Crohn's disease, celiac disease, and lactose intolerance.

There are many causes of gastrointestinal disorders, such as bacterial and viral infection, inflammation, poor circulation to the intestines, muscle dysfunction, gallstones, stress, particularly long-term use of anti-inflammatory drugs.

Conventional medicine used for the treatment of gastrointestinal disorders are depending on the disease that triggers the disorder.such as antibiotics for bacterial infection, painkillers for stomach pain.

Sherry Coleman Collins, MS, RDN, LD in the article, Natural Remedies for Digestive Disorders outlined the percentage of the use of natural remedies for the treatment of gastrointestinal disorders, and how much money that the American spend a year in purchasing these remedy.

Believe it or not, it is equivalent to about one-third of out-of-pocket dollars spent on prescription drugs.

The dietitian wrote, " more clients and patients are looking for ways to treat their digestive disorders with natural medicines sold over the counter. According to a 2007 National Institutes of Health-funded survey on the use of complementary and alternative medicines in the United States, roughly 38% of adults use natural remedies, such as diet-based therapies (eg, gluten-free diets) and herbs, among others" and

"Also in 2007, it was estimated that nearly $34 billion was spent on complementary and alternative medicines, including about $15 billion on “nonvitamin, nonmineral, natural products:.


Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The pungent spice has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to reconfirm the traditional use of ginger against various gastric ailments, researchers at the Tehran University of Medical Sciences conducted an experiment to review the ginger effect in the prevention of antituberculosis-induced gastrointestinal adverse reactions.

A randomized pilot clinical trial included 60 patients who were placed into ginger and placebo groups (30 patients in each group) received either 500 mg ginger (Zintoma)(®) or placebo one-half hour before each daily dose of antituberculosis drugs for 4 weeks.

After examining the Patients' gastrointestinal complaints (nausea, vomiting, dyspepsia, and abdominal pain) and antituberculosis drug-induced hepatotoxicity were recorded during the study period, researchers showed that application ginger to the 48 (80%) patients experienced nausea caused by antituberculosis drug-induced gastrointestinal adverse reactions, reduced gastrointestinal disorders by 56% compared to 43% in the placebo.

Patients in the ginger group experienced less, but not statistically significant, antituberculosis drug-induced hepatotoxicity than the placebo group (16.7% vs 36.7%, respectively, p = 0.07).

Dr. Emrani Z, the lead author in the final report wrote, "ginger may be a potential option for prevention of antituberculosis drug-induced gastrointestinal adverse reactions including hepatotoxicity".

Additionally, in the concern of the use of aspirin is its side effect to cause ulceration and bleeding in the gastrointestinal tract, a joint study led by the North Carolina Agricultural and Technical State University was conducted to examine the ginger effect in reducing the risk of gastrointestinal disorder caused by injection of low dose aspirin.

Injection of ginger exerted a strong activity in the ameliorated ASA-induced gastric ulceration.
[6]-gingerol aspirinate (GAS), the combination of ginger bioactive compound [6[-gingerol and aspirin demonstrated anti-cancer properties in vitro and superior gastroprotective effects in mice.

The combination (GAS) was also able to survive stomach acid and decomposed in intestinal linings or after absorption simultaneously release ASA and [6]-gingerol.

GAS inactivates both COX-1 and COX-2 equally to reduce symptoms of inflammation and pain caused by ASA-induced gastric ulceration.

The findings suggested that ginger processes gastroprotective effects and GAS can be a therapeutic equivalent for ASA in inflammatory and proliferative diseases without the deleterious effects on stomach mucosa.

Taken altogether, ginger with abundant gingerols may be considered a functional food for the prevention and adjunct therapy for the treatment of gastrointestinal disorders with no side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe). by Haniadka R1, Saldanha E, Sunita V, Palatty PL, Fayad R, Baliga MS. (PubMed)
(2) Ginger for Prevention of Antituberculosis-induced Gastrointestinal Adverse Reactions IncludingHepatotoxicity: A Randomized Pilot Clinical Trial by Emrani Z1, Shojaei E2, Khalili H. (PubMed)
(3) Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer by Zhu Y1, Wang F1,2, Zhao Y1, Wang P1, Sang S. (PubMed)

#Phytochemical #Lycopene Inhibits #Hyperproliferation In Gastric Epithelial Cells Associated with the Risk of #ColonCancer, Researchers Say

By Kyle J. Norton

Hyperproliferation is a progression of highly invasive tumors associated with an abnormally high rate of cancer cell division, leading to rapid overgrowth of the tumor.

Gastric cancer or stomach cancer is a medical condition caused by irregular cell growth of the inner lining tissues of the stomach.

Most cancer of gastric starts in the cells on the inner lining of the stomach before penetrating into deeper layers.

At the advanced stage, cancerous gastric cells can also travel a distance away to an alternate DNA of healthy cells, leading a secondary metastasis.

According to the statistics provided by the Canadian Cancer Society, In 2017, approximately 3,500 Canadians were diagnosed with stomach cancer, and gastric cancer also caused the death of 2,100 including 1,300 women and 790 men.

There are major types of gastric cancer
*Adenocarcinoma, accounting for over 90% of gastric cancer diagnosed each year is a type of cancer developed in the innermost lining of the stomach (the mucosa).

* Lymphoma is a type of cancer associated with the immune system found in the wall of the stomach.

The most common symptoms of gastric cancer are heartburn or indigestion, abdominal pain or vague discomfort in the abdomen, usually above the navel, and a sense of fullness in the upper abdomen after eating a small meal accompanied by the general symptoms shared by other types of cancer.

In severe cases, if the oversize tumor has pressed on the nearby blood vessel, patients may experience the symptom of vomiting blood.

Out of many prevalent factors involved in the cancer onset, some researchers suggested the promotion of the Western diet may have a strong and negative implication on cancer occurrence in North America.

Dr. Bertuccio P, the lead scientist wrote, "An unfavorable role on GC emerged for the 'Western/unhealthy' dietary pattern, with an OR of 1.51 (95% CI: 1.21-1.89). This association was weaker for the distal/NOS (not otherwise specified) category (OR = 1.36) compared with the cardia GC (OR = 2.05). Among the a priori scores, the ORs ranged from 0.2 to 0.7 for the favorable and from 1.8 to 6.9 for the unfavorable ones".

And, "There is a ~2-fold difference in GC risk between a 'Prudent/healthy' diet-rich in fruits and vegetables, and a 'Western/unhealthy' diet-rich in starchy foods, meat, and fats".

Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

With an aim to find a potential compound for the treatment of invasive gastric cancer, researchers examined the lycopene effect on Helicobacter pylori (H pylori) colonized human stomach in the risk of gastric cancer.

According to the tested differentiation, injection of lycopene reduced ROS levels by inhibiting Jak1/Stat3 activation associated with increased levels of proinflammatory cytokines, alteration of Wnt/β-catenin multiprotein signal in induced cell proliferation, and differentiation.

Furthermore, the levels of ROS also are decreased observed by the inhibition of c-Myc, a protein that plays a critical role in cellular growth regulation and cellular metabolism, and cyclin E in cell duplication and cell proliferation in H pylori-infected AGS cells, derived from an adenocarcinoma of the stomach.
In other words, lycopene protects the gastric cell by constraining the expression of ROS through several aforementioned mechanisms.

Based on the findings, researchers said, " Lycopene might be a potential and promising nutrient for preventing H pylori-associated gastric diseases including gastric cancer".

Furthermore, according to the results of HGC-27 cells which were treated with varying concentrations of lycopene for 24, 48, 72,
* Lycopene displayed antiproliferative activity in HGC-27 cell lines.

* Lycopene inhibited HGC-27 by enhancing the protein LC3 which is essential for cancer cell autophagy and p-ERK protein expression that impaired regeneration of intracellular antioxidants.

Furthermore, in the gastric cancer nude mice model, lycopene treatment also significantly decreased tumor weight or tumor proliferation.

Taken altogether, lycopene may be considered a supplement for the prevention and treatment of gastric cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene treatment inhibits activation of Jak1/Stat3 and Wnt/β-catenin signaling and attenuates hyperproliferation in gastric epithelial cells byPark B1, Lim JW2, Kim H. (PubMed)
(2) INHIBITORY EFFECT OF LYCOPENE AGAINST THE GROWTH OF HUMAN GASTRIC CANCER CELLS by Zhou S1, Zhang R1, Bi T1, Lu Y1, Jiang L. (PubMed)
(3) Dietary patterns and gastric cancer risk: a systematic review and meta-analysis by Bertuccio P1, Rosato V, Andreano A, Ferraroni M, Decarli A, Edefonti V, La Vecchia C. (PubMed)