By Kyle J. Norton
A chronic wound is a wound that does not heal within a predictable period of time.
It may be a result of the interruption of the stage of wound healing or damage of the blood vessels that have a function in providing necessary conditions to promote the closure of the wound as seen in a diabetic leg ulcer.
In other words, any wound that does not heal within 3 months is considered a chronic wound.
According to the statistics provided by the study "An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds", approximately, 2% of the population in developed countries suffer from chronic wounds.
Additionally, every year, more than 305 million cases of acute, traumatic, and burn wounds are treated globally.
Believe it or not, chronic and acute wound affects more than nine times of people around the world compared to those living with cancer.
Some researchers suggested that pressure, trauma, and/or lower extremity wounds, increased bacterial load, interruption of the stage of wound healing including excessive proteases, degraded cell surface structures, and inappropriate treatment are considered the most potent causes of the conditions.
More precisely, if we can protect all stages of wound healing without interruption, the chronic wound can be preventable.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent for the treatment of pains, strains, muscle aches, and pains and to ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural compound for the treatment of chronic wounds, researchers examined the efficacy of bromelain-based enzymatic debridement of chronic wounds.
The study included 24 patients with chronic wounds of different aetiologies.
According to 2 consecutive single-arm studies assessing the enzymatic debridement efficacy in 2 medical centers, all wounds achieved an average of 68% ± 30% debridement in an average of 3.5 ± 2.8 enzymatic debridement 4-hour sessions.
17/24 patients showed responding wounds (venous, diabetic, pressure, and post-traumatic aetiologies) of an average of 85% ± 12% debridement in 3.2 ± 2.5 applications, compared to 7/24 patients with no response.
There were no adverse effects reported by the patients. Based on the findings, researchers wrote, "These preliminary results indicate the potential safety and efficacy of bromelain-based enzymatic debridement in chronic wounds".
In vitro, according to the results of two soft tissue healing--fibroblasts and microvascular endothelial cells--were used as mono- and co-culture with bromelain, bromelain attenuated endothelial cell, and fibroblast proliferation moderately.
The inhibition of cell proliferation was not associated with cell apoptosis but with cell cycle arrest in the G0 phase.
In the comparable test, bromelain did not reduce endothelial cell migration. whereas fibroblast migration was clearly slowed down.
In other words, bromelain displayed a significant decrease of myofibroblasts under both normoxic (from 19 to 12 %) and hypoxic conditions (from 22 to 15 %) coincident with higher levels of anti-inflammatory expression.
Based on the findings, researchers wrote, "Usage of bromelain as a therapeutic drug for chronic human wounds thus remains a very promising concept for the future".
Taken altogether, bromelain used alone or combined with other remedies may be considered supplements for the prevention and treatment of chronic wounds, pending the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Bromelain-based enzymatic debridement of chronic wounds: A preliminary report by Shoham Y1, Krieger Y1, Tamir E2, Silberstein E1, Bogdanov-Berezovsky A1, Haik J3, Rosenberg L. (PubMed)
(2) Bromelain down-regulates myofibroblast differentiation in an in vitro wound healing assay by Aichele K1, Bubel M, Deubel G, Pohlemann T, Oberringer M. (PubMed)
Sunday, 4 June 2023
#Phytochemical #Indole3Carbinol Found in #CruciferousVegetables Exhibit Anti #Cancer Activities, Scientists Suggest
By Kyle J. Norton
Intake of cruciferous vegetables may reduce the risk of cancers, some scientists suggested.
Cancers are a group of chronic and medical diseases characterized by irregular cell growth in the body tissue caused by the change of DNA transcription of healthy cells.
Normal cells have the division of a limited cell cycle compared to a cancerous cell which can grow unlimitedly.
If an invasive tumor is growing too large, it can suppress the nerves and muscles surrounding them, leading to persistent pain and other symptoms, depending on the location.
The exact causes of cancer are unknown. Researchers do not know why people with the same health condition, are susceptible to the onset of the diseases, while others do not.
However, an unhealthy diet, such as eating processed foods and fast foods, and lifestyles such as smoking, being overweight, physical inactivity, and excessive alcohol drinking are some of the major causes of cancer.
Truly, according to the article written by the Telegraph, an unhealthy lifestyle is responsible for half of the onset of cancers. And overweight or obese is a cause of 12 types of cancer.
Other prevalent risk factors of cancer are genetic mutation inherited from the parents, environment toxic chemicals, radiation, virus, hormone imbalance,... and chronic inflammatory diseases.
Besides the general symptoms such as lumps, loss of appetite, fatigue, tiredness, and unintended weight loss, patients with cancers also experience some symptoms totally depended on the location, types, and grade of infected tissues and organs,
Cruciferous vegetables are a group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.
According to a recent study, indole-3-carbinol (I3C), a substance present in cruciferous vegetables suppressed the proliferation of different tumor cells, including those isolated from breast, prostate, endometrium, and colon cancers, in vitro.
Dr. Popolo A, the lead author suggested, the effect of the chemical compound in the treatment of various cancers may be attributed to the interference of cancer cell cycle division and expression of a diverse set of genes involved in cell differentiation.
Dr. Aggarwal BB and Dr. Ichikawa H. in the additional examination of the function of indole-3-carbinol (I3C) also found that application of the phytochemical also inhibited DNA-carcinogen abducted and new blood vessels involved cancer cell survival formation, suppressed free-radical production, and stimulated 2-hydroxylation of estradiol in the reduction of cell proliferative and estrogenic activity and
Furthermore, indole-3-carbinol and its derivatives not only exerted anti-cancer effects by restoring original gene formation but also inhibited free radicals production, ... but also interfered with the cancer cell cycle division phase to induce apoptosis.
Other chemical compounds found in the cruciferous vegetables, shown to possess potent antitumor and chemopreventive activity are sulforaphane (SFN), an isothiocyanate, and Allyl nitrile (3-butene nitrile).
Taking together, there is no doubt, cruciferous vegetables have exhibited anticancer activities, through many aspects.
Intake of cruciferous vegetables regularly is associated with reduced risk and treatment of various types of cancer.
However, further data collection on large example size and multi-center studies performed with human consumption of the whole food of cruciferous vegetables during the course of the disease will be necessary to complete the picture of cruciferous vegetables' anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Two likely targets for the anti-cancer effect of indole derivatives from cruciferous vegetables: PI3K/Akt/mTOR signaling pathway and the aryl hydrocarbon receptor by Popolo A1, Pinto A1, Daglia M2, Nabavi SF3, Farooqi AA4, Rastrelli L5. (PubMed)
(2) Molecular targets and anticancer potential of indole-3-carbinol and its derivatives by Aggarwal BB1, Ichikawa H.(PubMed)
(3) Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells by Liu KC1, Shih TY1, Kuo CL2, Ma YS3,4, Yang JL2, Wu PP5, Huang YP6, Lai KC7,8, Chung JG9,10. (PubMed)
(4) Allyl nitrile: Toxicity and health effects by Tanii H1.(PubMed)
Intake of cruciferous vegetables may reduce the risk of cancers, some scientists suggested.
Cancers are a group of chronic and medical diseases characterized by irregular cell growth in the body tissue caused by the change of DNA transcription of healthy cells.
Normal cells have the division of a limited cell cycle compared to a cancerous cell which can grow unlimitedly.
If an invasive tumor is growing too large, it can suppress the nerves and muscles surrounding them, leading to persistent pain and other symptoms, depending on the location.
The exact causes of cancer are unknown. Researchers do not know why people with the same health condition, are susceptible to the onset of the diseases, while others do not.
However, an unhealthy diet, such as eating processed foods and fast foods, and lifestyles such as smoking, being overweight, physical inactivity, and excessive alcohol drinking are some of the major causes of cancer.
Truly, according to the article written by the Telegraph, an unhealthy lifestyle is responsible for half of the onset of cancers. And overweight or obese is a cause of 12 types of cancer.
Other prevalent risk factors of cancer are genetic mutation inherited from the parents, environment toxic chemicals, radiation, virus, hormone imbalance,... and chronic inflammatory diseases.
Besides the general symptoms such as lumps, loss of appetite, fatigue, tiredness, and unintended weight loss, patients with cancers also experience some symptoms totally depended on the location, types, and grade of infected tissues and organs,
Cruciferous vegetables are a group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.
According to a recent study, indole-3-carbinol (I3C), a substance present in cruciferous vegetables suppressed the proliferation of different tumor cells, including those isolated from breast, prostate, endometrium, and colon cancers, in vitro.
Dr. Popolo A, the lead author suggested, the effect of the chemical compound in the treatment of various cancers may be attributed to the interference of cancer cell cycle division and expression of a diverse set of genes involved in cell differentiation.
Dr. Aggarwal BB and Dr. Ichikawa H. in the additional examination of the function of indole-3-carbinol (I3C) also found that application of the phytochemical also inhibited DNA-carcinogen abducted and new blood vessels involved cancer cell survival formation, suppressed free-radical production, and stimulated 2-hydroxylation of estradiol in the reduction of cell proliferative and estrogenic activity and
Furthermore, indole-3-carbinol and its derivatives not only exerted anti-cancer effects by restoring original gene formation but also inhibited free radicals production, ... but also interfered with the cancer cell cycle division phase to induce apoptosis.
Other chemical compounds found in the cruciferous vegetables, shown to possess potent antitumor and chemopreventive activity are sulforaphane (SFN), an isothiocyanate, and Allyl nitrile (3-butene nitrile).
Taking together, there is no doubt, cruciferous vegetables have exhibited anticancer activities, through many aspects.
Intake of cruciferous vegetables regularly is associated with reduced risk and treatment of various types of cancer.
However, further data collection on large example size and multi-center studies performed with human consumption of the whole food of cruciferous vegetables during the course of the disease will be necessary to complete the picture of cruciferous vegetables' anti-cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Two likely targets for the anti-cancer effect of indole derivatives from cruciferous vegetables: PI3K/Akt/mTOR signaling pathway and the aryl hydrocarbon receptor by Popolo A1, Pinto A1, Daglia M2, Nabavi SF3, Farooqi AA4, Rastrelli L5. (PubMed)
(2) Molecular targets and anticancer potential of indole-3-carbinol and its derivatives by Aggarwal BB1, Ichikawa H.(PubMed)
(3) Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells by Liu KC1, Shih TY1, Kuo CL2, Ma YS3,4, Yang JL2, Wu PP5, Huang YP6, Lai KC7,8, Chung JG9,10. (PubMed)
(4) Allyl nitrile: Toxicity and health effects by Tanii H1.(PubMed)
#Herbal #Turmeric Protects the Heart Muscles Against the Onset of HeartDiseases and Strokes, Researchers Say
By Kyle J. Norton
Cardiomyocyte hypertrophy is a medical condition characterized by the thickening of the heart muscle, leading to reduced function of the heart in pumping blood throughout the body.
The heart-formed part of the circulatory system is a muscular organ that pumps blood through the body's blood vessels to provide oxygen and nutrients and remove metabolic wastes.
The heart muscles made up the bulk of the heart’s mass control the heartbeat with high contractile strength and endurance.
Cardiac muscle also has a unique function to regulate heart performance by spreading electrochemical signals to all cells in the heart.
Damage of the heart muscle has been found to induce blood vessel diseases, such as coronary artery disease; heart rhythm problems (arrhythmias).
In some cases, heart muscle disease also is found in patients with congenital heart defects.
The most common symptoms of cardiac hypertrophy are breathlessness with exertion or at rest, legs, ankles, and feet swelling. persistent fatigue, dizziness, lightheadedness, and fainting, particularly, in the symptoms of irregular heartbeats.
Conventionally, treatments of cardiac hypertrophy are totally depending on the type of heart disease, including lowering blood pressure medication such as ACE inhibitors; lowing the heart rate, such as beta-blockers, normalizing heart beating, and balancing electrolytes in the body.
Making a healthy lifestyle change and moderate exercise may also recommend by your doctor.
Cardiac hypertrophy has been found in patients with uncontrol high blood pressure accompanied by tobacco smoking. The condition is a common risk factor for heart attack and stroke.
Dr. Thomas Kahan, the lead scientist wrote, "Myocardial hypertrophy is also part of the remodeling process following an acute myocardial infarction, and is a common finding in patients with congestive heart failure caused by systolic and/or diastolic LV dysfunction".
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On findings a potential compound for the treatment of heart failure, researchers examined the efficacy of curcumin an anti-hypertrophic potential.
According to the tested analysis, curcumin encapsulated by carboxymethyl chitosan (CMC) nanoparticle conjugated to a myocyte specific homing peptide was effective in the regression of cardiac hypertrophy in a rat (Rattus norvegicus) model.
Curcumin at a low dose of 5 mg/kg body weight compared to free Curcumin at 35 mg/kg body weight. showed a higher cardiac bioavailability, compared to other concentrations.
Furthermore, cardiac function during hypertrophy was significantly improved by the application of Curcumin/CMC-peptide by inhibiting the hypertrophy marker genes (ANF, β-MHC) and apoptotic mediators (Bax, Cytochrome-c) and activity of apoptotic markers (Caspase 3 and PARP) in the lower doses compared to higher doses.
Targeted Curcumin treatment significantly lowered p53 expression which is associated with pro-apoptotic function in cardiac hypertrophy.
Based on the findings, researchers wrote, "Curcumin and also attributes towards probable mechanistic insight into its therapeutic potential as a cardio-protective agent for regression of cardiac hypertrophy".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of cardiac hypertrophy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Improved bioavailability of targeted Curcumin delivery efficiently regressed cardiac hypertrophy by modulating apoptotic load within cardiacmicro environment by Ray A1, Rana S2, Banerjee D3, Mitra A4, Datta R5, Naskar S6, Sarkar S. (PubMed)
(2) Left ventricular hypertrophy in hypertension: its arrhythmogenic potential by Thomas Kahan1 and Lennart Bergfeldt. (PMC)
Cardiomyocyte hypertrophy is a medical condition characterized by the thickening of the heart muscle, leading to reduced function of the heart in pumping blood throughout the body.
The heart-formed part of the circulatory system is a muscular organ that pumps blood through the body's blood vessels to provide oxygen and nutrients and remove metabolic wastes.
The heart muscles made up the bulk of the heart’s mass control the heartbeat with high contractile strength and endurance.
Cardiac muscle also has a unique function to regulate heart performance by spreading electrochemical signals to all cells in the heart.
Damage of the heart muscle has been found to induce blood vessel diseases, such as coronary artery disease; heart rhythm problems (arrhythmias).
In some cases, heart muscle disease also is found in patients with congenital heart defects.
The most common symptoms of cardiac hypertrophy are breathlessness with exertion or at rest, legs, ankles, and feet swelling. persistent fatigue, dizziness, lightheadedness, and fainting, particularly, in the symptoms of irregular heartbeats.
Conventionally, treatments of cardiac hypertrophy are totally depending on the type of heart disease, including lowering blood pressure medication such as ACE inhibitors; lowing the heart rate, such as beta-blockers, normalizing heart beating, and balancing electrolytes in the body.
Making a healthy lifestyle change and moderate exercise may also recommend by your doctor.
Cardiac hypertrophy has been found in patients with uncontrol high blood pressure accompanied by tobacco smoking. The condition is a common risk factor for heart attack and stroke.
Dr. Thomas Kahan, the lead scientist wrote, "Myocardial hypertrophy is also part of the remodeling process following an acute myocardial infarction, and is a common finding in patients with congestive heart failure caused by systolic and/or diastolic LV dysfunction".
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On findings a potential compound for the treatment of heart failure, researchers examined the efficacy of curcumin an anti-hypertrophic potential.
According to the tested analysis, curcumin encapsulated by carboxymethyl chitosan (CMC) nanoparticle conjugated to a myocyte specific homing peptide was effective in the regression of cardiac hypertrophy in a rat (Rattus norvegicus) model.
Curcumin at a low dose of 5 mg/kg body weight compared to free Curcumin at 35 mg/kg body weight. showed a higher cardiac bioavailability, compared to other concentrations.
Furthermore, cardiac function during hypertrophy was significantly improved by the application of Curcumin/CMC-peptide by inhibiting the hypertrophy marker genes (ANF, β-MHC) and apoptotic mediators (Bax, Cytochrome-c) and activity of apoptotic markers (Caspase 3 and PARP) in the lower doses compared to higher doses.
Targeted Curcumin treatment significantly lowered p53 expression which is associated with pro-apoptotic function in cardiac hypertrophy.
Based on the findings, researchers wrote, "Curcumin and also attributes towards probable mechanistic insight into its therapeutic potential as a cardio-protective agent for regression of cardiac hypertrophy".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of cardiac hypertrophy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been referenced in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Improved bioavailability of targeted Curcumin delivery efficiently regressed cardiac hypertrophy by modulating apoptotic load within cardiacmicro environment by Ray A1, Rana S2, Banerjee D3, Mitra A4, Datta R5, Naskar S6, Sarkar S. (PubMed)
(2) Left ventricular hypertrophy in hypertension: its arrhythmogenic potential by Thomas Kahan1 and Lennart Bergfeldt. (PMC)
#Ashwagandha Promotes The Healthy Neuron Activity and Brain Functioning by Inhibiting the #Overexpression #OxidativeStress, Researchers Say
By Kyle J. Norton
The brain formed part of the central nervous system is the most complex organ made up of more than billions of nerve cells or neurons.
The functions of the brain are associated with the communication of trillions of connections called synapses and many specialized regions.
A neuron or nerve cell made of a cell body (also called soma), dendrites, and an axon, is a cell in the nervous system that carries electrical impulses.
Neurons are core components of the brain, spinal cord, and peripheral nerves that play an essential role to process and transmitting information.
The function of neurons can be classified into 3 types
* The sensory neurons found within the nervous system that convert external stimuli from the organism's environment into internal electrical impulses. In other words, sensory neurons are activated by sensory input from the environment, including physical input of sound, touch, heat, or light.
* The motor neurons transmit information from the spinal cord to skeletal and smooth muscles,. In other words, motor neurons directly control all of the muscle movements.
* The interneurons connect the motor and sensory neurons. In other words, the interneurons transfer signals between sensory and motor neurons.
Believe it or not, there are more than 600 diseases of the central nervous system, including brain tumors, epilepsy, dementia such as Parkinson's disease and Alzheimer's disease, and stroke.
The top 3 neurological diseases include
* Alzheimer's disease (AD) is a neurodegenerative disease in the elderly, associated with the worsening of memory, thinking, and behavior that severe enough to affect language communication, memory, lifelong hobbies, or social life
* Bell's Palsy is a condition caused by sudden weakness or paralysis of facial muscles on one side of the face.
* Cerebral Palsy is a neurological disorder of children affecting a child's movement, motor skills, and muscle tone.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In finding a potent compound for the treatment of brain health, researchers examined the effects of Ashwagandha (WA) extracts (alcoholic and water) and their bioactive components for neuroprotective activities against oxidative stress in cultured glioblastoma and neuroblastoma cells.
According to the tested analysis, the extracts and one of the purified components at a low dose protected the glial and neuronal cells from oxidation, an important activity that promotes neuron activity.
Furthermore, glutamate insult induced by oxidative stress was also inhibited by the application of Ashwagandha (WA) extracts (alcoholic and water) and their bioactive components.
Based on the findings, researchers said, "the combinations of extracts and active component were highly potent endorsing the therapeutic merit of the combinational approach".
And, "Ashwagandha leaf-derived bioactive compounds have neuroprotective potential and may serve as a supplement for brain health.s".
Taken altogether, Ashwagandha may be considered a functional herb for the promotion of brain functioning, pending the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combinations of Ashwagandha leaf extracts protect brain-derived cells against oxidative stress and induce differentiation by Shah N1, Singh R1, Sarangi U1, Saxena N1, Chaudhary A1, Kaur G2, Kaul SC1, Wadhwa R. (PubMed)
(2) Protective role of Ashwagandha leaf extract and its component withanone on scopolamine-induced changes in the brain and brain-derived cells by Konar A1, Shah N, Singh R, Saxena N, Kaul SC, Wadhwa R, Thakur MK. (PubMed)
The brain formed part of the central nervous system is the most complex organ made up of more than billions of nerve cells or neurons.
The functions of the brain are associated with the communication of trillions of connections called synapses and many specialized regions.
A neuron or nerve cell made of a cell body (also called soma), dendrites, and an axon, is a cell in the nervous system that carries electrical impulses.
Neurons are core components of the brain, spinal cord, and peripheral nerves that play an essential role to process and transmitting information.
The function of neurons can be classified into 3 types
* The sensory neurons found within the nervous system that convert external stimuli from the organism's environment into internal electrical impulses. In other words, sensory neurons are activated by sensory input from the environment, including physical input of sound, touch, heat, or light.
* The motor neurons transmit information from the spinal cord to skeletal and smooth muscles,. In other words, motor neurons directly control all of the muscle movements.
* The interneurons connect the motor and sensory neurons. In other words, the interneurons transfer signals between sensory and motor neurons.
Believe it or not, there are more than 600 diseases of the central nervous system, including brain tumors, epilepsy, dementia such as Parkinson's disease and Alzheimer's disease, and stroke.
The top 3 neurological diseases include
* Alzheimer's disease (AD) is a neurodegenerative disease in the elderly, associated with the worsening of memory, thinking, and behavior that severe enough to affect language communication, memory, lifelong hobbies, or social life
* Bell's Palsy is a condition caused by sudden weakness or paralysis of facial muscles on one side of the face.
* Cerebral Palsy is a neurological disorder of children affecting a child's movement, motor skills, and muscle tone.
Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
In finding a potent compound for the treatment of brain health, researchers examined the effects of Ashwagandha (WA) extracts (alcoholic and water) and their bioactive components for neuroprotective activities against oxidative stress in cultured glioblastoma and neuroblastoma cells.
According to the tested analysis, the extracts and one of the purified components at a low dose protected the glial and neuronal cells from oxidation, an important activity that promotes neuron activity.
Furthermore, glutamate insult induced by oxidative stress was also inhibited by the application of Ashwagandha (WA) extracts (alcoholic and water) and their bioactive components.
Based on the findings, researchers said, "the combinations of extracts and active component were highly potent endorsing the therapeutic merit of the combinational approach".
And, "Ashwagandha leaf-derived bioactive compounds have neuroprotective potential and may serve as a supplement for brain health.s".
Taken altogether, Ashwagandha may be considered a functional herb for the promotion of brain functioning, pending the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Combinations of Ashwagandha leaf extracts protect brain-derived cells against oxidative stress and induce differentiation by Shah N1, Singh R1, Sarangi U1, Saxena N1, Chaudhary A1, Kaur G2, Kaul SC1, Wadhwa R. (PubMed)
(2) Protective role of Ashwagandha leaf extract and its component withanone on scopolamine-induced changes in the brain and brain-derived cells by Konar A1, Shah N, Singh R, Saxena N, Kaul SC, Wadhwa R, Thakur MK. (PubMed)
#Antioxidant #Alliin Inhibits the Onset of Hypertension, Researchers Suggest
By Kyle J. Norton
Hypertension, found in the cluster of metabolic syndrome is a medical condition associated with abnormally high blood pressure.
Blood pressure change constantly depending on the activity. Persistent hypertension over time can lead to diabetes and cardiovascular disease.
It also is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
According to the statistics provided by the American Heart Association., approximately 103 million U.S. adults are living with high blood pressure, accounting for nearly half of all adults in the United States.
Conventionally, blood pressure medications have been found to prevent many deaths from heart disease and stroke over the past 30 years, however, long-term intake of such medications has caused many side effects such as damaging the kidney.
Epidemiologically, family history, aging, being male, being overweight or obese, ethnicity, physical inactivity, unhealthy diet, and people with chronic kidney disease are some common risk factors involved in the increased risk of hypertension.
Believe it or not, excessive alcohol drinking is also one of the major causes besides obesity in elevating the syndrome onset.
Dr. Kazim Husain wrote, "Several possible mechanisms have been proposed such as an imbalance of the central nervous system, impairment of the baroreceptors, enhanced sympathetic activity, stimulation of the renin-angiotensin-aldosterone system, increased cortisol levels, increased vascular reactivity due to increasing in intracellular calcium levels, stimulation of the endothelium to release vasoconstrictors and loss of relaxation due to inflammation and oxidative injury of the endothelium leading to inhibition of endothelium-dependent nitric oxide production".
And, "Loss of relaxation due to inflammation and oxidative injury of the endothelium by angiotensin II leading to inhibition of endothelium-dependent nitric oxide production is the major contributor to alcohol-induced hypertension".
In fact, by making changes to lifestyle, maintaining an ideal weight, and diet with low salt, you could do just fine without the drugs.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belongings to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential compound for the treatment of hypertension, researchers examined the effect of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) in rats fed with a high cholesterol diet.
The study was carried out with rats fed a 2% high cholesterol diet with and without garlic powder and control rats were fed a normal diet for 6 weeks daily.
Rats treated with a high-cholesterol diet had significantly higher blood pressure compared to the animals receiving the control diet.
Compared to the high cholesterol and control diet group, the blood pressure of the animals receiving garlic powder was significantly lower without changing the levels of serum glucose and protein in all of the rats.
The results strongly showed support for the use of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6 % allicin) for the treatment of systolic blood pressure in hypercholesterolemic in an animal model.
Dr. Ali M the lead scientist said, "Our experimental results show that garlic may beneficially affect .....hypertension".
Taken altogether, alliin may be considered a supplement for the prevention and treatment of hypertension, pending the confirmation of the larger sample size and multicenter human study.
Intake of Alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet by Ali M1, Al-Qattan KK, Al-Enezi F, Khanafer RM, Mustafa T. (PubMed)
(2) Alcohol-induced hypertension: Mechanism and prevention by Kazim Husain, Rais A Ansari, and Leon Ferder. (PMC)
Hypertension, found in the cluster of metabolic syndrome is a medical condition associated with abnormally high blood pressure.
Blood pressure change constantly depending on the activity. Persistent hypertension over time can lead to diabetes and cardiovascular disease.
It also is the force of blood pushing against the walls of the arteries as the heart pumps out blood.
According to the statistics provided by the American Heart Association., approximately 103 million U.S. adults are living with high blood pressure, accounting for nearly half of all adults in the United States.
Conventionally, blood pressure medications have been found to prevent many deaths from heart disease and stroke over the past 30 years, however, long-term intake of such medications has caused many side effects such as damaging the kidney.
Epidemiologically, family history, aging, being male, being overweight or obese, ethnicity, physical inactivity, unhealthy diet, and people with chronic kidney disease are some common risk factors involved in the increased risk of hypertension.
Believe it or not, excessive alcohol drinking is also one of the major causes besides obesity in elevating the syndrome onset.
Dr. Kazim Husain wrote, "Several possible mechanisms have been proposed such as an imbalance of the central nervous system, impairment of the baroreceptors, enhanced sympathetic activity, stimulation of the renin-angiotensin-aldosterone system, increased cortisol levels, increased vascular reactivity due to increasing in intracellular calcium levels, stimulation of the endothelium to release vasoconstrictors and loss of relaxation due to inflammation and oxidative injury of the endothelium leading to inhibition of endothelium-dependent nitric oxide production".
And, "Loss of relaxation due to inflammation and oxidative injury of the endothelium by angiotensin II leading to inhibition of endothelium-dependent nitric oxide production is the major contributor to alcohol-induced hypertension".
In fact, by making changes to lifestyle, maintaining an ideal weight, and diet with low salt, you could do just fine without the drugs.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide, a derivative of the amino acid cysteine, belongings to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a potential compound for the treatment of hypertension, researchers examined the effect of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6% allicin) in rats fed with a high cholesterol diet.
The study was carried out with rats fed a 2% high cholesterol diet with and without garlic powder and control rats were fed a normal diet for 6 weeks daily.
Rats treated with a high-cholesterol diet had significantly higher blood pressure compared to the animals receiving the control diet.
Compared to the high cholesterol and control diet group, the blood pressure of the animals receiving garlic powder was significantly lower without changing the levels of serum glucose and protein in all of the rats.
The results strongly showed support for the use of Lichtwer garlic powder (containing 1.3% alliin equivalent to 0.6 % allicin) for the treatment of systolic blood pressure in hypercholesterolemic in an animal model.
Dr. Ali M the lead scientist said, "Our experimental results show that garlic may beneficially affect .....hypertension".
Taken altogether, alliin may be considered a supplement for the prevention and treatment of hypertension, pending the confirmation of the larger sample size and multicenter human study.
Intake of Alliin in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet by Ali M1, Al-Qattan KK, Al-Enezi F, Khanafer RM, Mustafa T. (PubMed)
(2) Alcohol-induced hypertension: Mechanism and prevention by Kazim Husain, Rais A Ansari, and Leon Ferder. (PMC)
#Herbal #Anise in the Promotion of #WomensHealth, Researchers Suggest
By Kyle J. Norton
Anise may have a potential and substantial effect in promoting women's health in all aspects, some scientists suggested.
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic,...
In the study of Anise estrogenic activity at doses levels of 50 mg, 70 mg, and 80 mg/kg PO. in rats, researchers found that application of Anise at all doses exerted a strong estrogenic effect without affecting the levels of progestational, anti-progestational, androgenic or anti-androgenic activities and inducing any side effects even at the doses of more than 3000 mg/kg with LD50, an indication of 50% percent of a population of animals killed usually within a certain time due to some application in a dose-dependent manner.
Also, in the investigation of the Anise estrogenic effect, researchers found that the application of Anise displayed estrogenic activity through increased milk secretion, promoting menstruation, facilitating birth, alleviating the symptoms of the male climacteric, and increasing libido.
Further analysis, also suggested that the implication of fennel estrogenic activity was associated with the major bioactive compound anethole found at high levels in the fennel essential oil.
However, even with a lesser amount in fennel essential oil, polymers of anethole, the derivative of di anethole, and photo anethole are considered actual pharmacological values in testing for the drug in the treatment of estrogenic deficiency-related diseases, including menstrual disorder, libido, menopause symptoms, male climacteric,.....
The above differentiation was supported by the evaluation of the estrogenic activity of essential oils of eleven Pimpinella species and the compounds isolated from these species, conducted by Anadolu University.
According to the yeast estrogen screen (YES) assay in the study, Anise essential oils containing (E)-anethole as major compounds showed estrogenic activity, compared to insignificant expression in aerial parts without fruits of P. anisetum and P. flabellifolia.
In the presence of anethole-containing oils from 30-50%, Anise exerted the maximal response in expression estrogenic activity.
Interestingly, Fruits of P. isaurica and P. peucedanifolia were estrogenic in spite of the absence or trace amount of anethole.
These results suggested that the estrogenic activity of Pimpinella oils may also be contributed by other components other than anethole.
In other words, anethole, a major bioactive compound may not be solely responsible for contributing towards estrogenic activity and essential oil isolated from different parts of the plant and species expressed a varied in estrogenic potencies compared to 17 beta-estradiol.
In herbal Anise, the fruit oils were most estrogenic followed by the aerial parts without fruits and the root oils and their EC50 values varied from 45 micrograms/mL to 650 micrograms/mL.
Taken together, Anise and its major bioactive compound anethole may be considered as a functional food for reduced risk, progression, and treatment of estrogenic deficiency syndrome and diseases, such as menopause symptoms and women's reproductive diseases.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Fennel and anise as estrogenic agents BY MichaelAlbert-Puleo(Science Direct)
(2) Estrogenic activity of isolated compounds and essential oils of Pimpinella species from Turkey, evaluated using a recombinant yeast screen by Tabanca N1, Khan SI, Bedir E, Annavarapu S, Willett K, Khan IA, Kirimer N, Baser KH.(PubMed)
(3) Anti-fertility activity and hormonal profile of trans-anethole in rats by Dhar SK1(PubMed)
Anise may have a potential and substantial effect in promoting women's health in all aspects, some scientists suggested.
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic,...
In the study of Anise estrogenic activity at doses levels of 50 mg, 70 mg, and 80 mg/kg PO. in rats, researchers found that application of Anise at all doses exerted a strong estrogenic effect without affecting the levels of progestational, anti-progestational, androgenic or anti-androgenic activities and inducing any side effects even at the doses of more than 3000 mg/kg with LD50, an indication of 50% percent of a population of animals killed usually within a certain time due to some application in a dose-dependent manner.
Also, in the investigation of the Anise estrogenic effect, researchers found that the application of Anise displayed estrogenic activity through increased milk secretion, promoting menstruation, facilitating birth, alleviating the symptoms of the male climacteric, and increasing libido.
Further analysis, also suggested that the implication of fennel estrogenic activity was associated with the major bioactive compound anethole found at high levels in the fennel essential oil.
However, even with a lesser amount in fennel essential oil, polymers of anethole, the derivative of di anethole, and photo anethole are considered actual pharmacological values in testing for the drug in the treatment of estrogenic deficiency-related diseases, including menstrual disorder, libido, menopause symptoms, male climacteric,.....
The above differentiation was supported by the evaluation of the estrogenic activity of essential oils of eleven Pimpinella species and the compounds isolated from these species, conducted by Anadolu University.
According to the yeast estrogen screen (YES) assay in the study, Anise essential oils containing (E)-anethole as major compounds showed estrogenic activity, compared to insignificant expression in aerial parts without fruits of P. anisetum and P. flabellifolia.
In the presence of anethole-containing oils from 30-50%, Anise exerted the maximal response in expression estrogenic activity.
Interestingly, Fruits of P. isaurica and P. peucedanifolia were estrogenic in spite of the absence or trace amount of anethole.
These results suggested that the estrogenic activity of Pimpinella oils may also be contributed by other components other than anethole.
In other words, anethole, a major bioactive compound may not be solely responsible for contributing towards estrogenic activity and essential oil isolated from different parts of the plant and species expressed a varied in estrogenic potencies compared to 17 beta-estradiol.
In herbal Anise, the fruit oils were most estrogenic followed by the aerial parts without fruits and the root oils and their EC50 values varied from 45 micrograms/mL to 650 micrograms/mL.
Taken together, Anise and its major bioactive compound anethole may be considered as a functional food for reduced risk, progression, and treatment of estrogenic deficiency syndrome and diseases, such as menopause symptoms and women's reproductive diseases.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Fennel and anise as estrogenic agents BY MichaelAlbert-Puleo(Science Direct)
(2) Estrogenic activity of isolated compounds and essential oils of Pimpinella species from Turkey, evaluated using a recombinant yeast screen by Tabanca N1, Khan SI, Bedir E, Annavarapu S, Willett K, Khan IA, Kirimer N, Baser KH.(PubMed)
(3) Anti-fertility activity and hormonal profile of trans-anethole in rats by Dhar SK1(PubMed)
#Herbal #Turmeric Inhibits the Production of #ProinflmmatoryCytokines Against the Onset of Vascular Inflammation, Researchers Say
By Kyle J. Norton
Inflammation is a natural reaction of the immune system's self-protection to remove harmful stimuli, including damaged cells, irritants, and pathogens... from our body.
Acute inflammatory inflammation results from the over-response of the immune system after sensing the injury or damage of the body by activating the protein associated with the production of pro-inflammatory cytokines.
The aim of the proinflammatory cytokines is to kill the invasive pathogens, which try to enter the body through the wound.
In the acute phase of infection, the immune system in the stimulating production of proinflammatory cytokines may induce overproduction of these cytokines can cause death or damage to the nearby cells, leading to scar formation and symptoms of localized swelling, redness, and fever.
Chronic inflammation is a serious condition caused by the immune system's to adapt to the new change due to its inability to kill all the invasions within a set of times.
Vasoprotection is the process to improve the function of the blood vessels, including the use of herbal and natural remedies.
Blood vessels are the tubular structure including a vein, artery, or capillary which carries the blood through the tissues and organs pumped by the heart.
There 3 main types of blood vessels arteries that deliver oxygen-rich blood from the heart to the tissues and organs of the body. Damage of arteries may induce coronary artery disease associated with the narrowing or blockage of the coronary arteries due to plaques accumulated in the arterial wall.
The veins carry blood toward the heart. Chronic venous insufficiency (CVI) is a common condition associated with a disease of the veins that affects up to 20 percent of adults.
The capillaries or the smallest blood vessels found to induce systemic capillary leak syndrome (SCLS) is a rare acquired disorder.
Vascular inflammation is a condition associated with blood vessel inflammation caused by the overexpression of pro-inflammatory cytokines involved in vascular inflammation. Atherosclerosis is characterized by chronic inflammation of the vascular wall.
Chronic vascular inflammation has been found to cause historical changes in the blood vessel walls, leading to blood vessel wall thickening, weakening, narrowing, or scarring on orchestrating blood flow restriction, resulting in organ and tissue damage.
The most common symptoms of vascular inflammation are associated with reduced blood flow to supply nutrients and fluid to the body tissues, including fever, headache, fatigue, general aches, and pains, night sweats, rash, numbness, and weakness.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
On findings, a potential compound for the treatment of acute vascular inflammation researchers evaluated the anti-inflammatory activity, and the cytotoxic effect of a novel chemically modified, non-carbonyl compound enriched Curcuma longa L. (C. longa) extract (CMCE).
According to the tested analysis, CMCE at the concentration of 1 or 10 μg/mL at 14 h, significantly decreased LPS (50-100 ng/mL) induced production of pro-inflammatory cytokines including TLR4 expression in THP-1 cells, human, and mouse whole blood.
In THP-1 cells, CMCE inhibited the expression of IRAK1, which plays a critical role in initiating an innate immune response against foreign pathogens, MAPK is involved in directing cellular responses to a diverse array of stimuli.
CMCE (30, 100, and 300 mg/kg; 10 days p.o.) pre-treated and LPS (10 mg/kg) in Swiss mice exhibited attenuated plasma TNF-α, IL-1β, nitrite, aortic iNOS expression, and vascular dysfunction associated with the production of pro-inflammatory cytokines.
In HL-60 cells., CMCE. exerted cytotoxic effects through cell cycle arrest on the Sub-G1 phase, increased apoptotic cells, loss of mitochondrial membrane in the cancer cells, and activation of cascade associated with pro-apoptosis.
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of vascular inflammation, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A Standardized Chemically Modified Curcuma longa Extract Modulates IRAK-MAPK Signaling in Inflammation and Potentiates Cytotoxicity by Rana M1, Maurya P1, Reddy SS1, Singh V1, Ahmad H2, Dwivedi AK2, Dikshit M1, Barthwal MK. (PubMed)
(2) Curcumin: An Effective Inhibitor of Interleukin-6 by Ghandadi M1, Sahebkar A. (PubMed)
Inflammation is a natural reaction of the immune system's self-protection to remove harmful stimuli, including damaged cells, irritants, and pathogens... from our body.
Acute inflammatory inflammation results from the over-response of the immune system after sensing the injury or damage of the body by activating the protein associated with the production of pro-inflammatory cytokines.
The aim of the proinflammatory cytokines is to kill the invasive pathogens, which try to enter the body through the wound.
In the acute phase of infection, the immune system in the stimulating production of proinflammatory cytokines may induce overproduction of these cytokines can cause death or damage to the nearby cells, leading to scar formation and symptoms of localized swelling, redness, and fever.
Chronic inflammation is a serious condition caused by the immune system's to adapt to the new change due to its inability to kill all the invasions within a set of times.
Vasoprotection is the process to improve the function of the blood vessels, including the use of herbal and natural remedies.
Blood vessels are the tubular structure including a vein, artery, or capillary which carries the blood through the tissues and organs pumped by the heart.
There 3 main types of blood vessels arteries that deliver oxygen-rich blood from the heart to the tissues and organs of the body. Damage of arteries may induce coronary artery disease associated with the narrowing or blockage of the coronary arteries due to plaques accumulated in the arterial wall.
The veins carry blood toward the heart. Chronic venous insufficiency (CVI) is a common condition associated with a disease of the veins that affects up to 20 percent of adults.
The capillaries or the smallest blood vessels found to induce systemic capillary leak syndrome (SCLS) is a rare acquired disorder.
Vascular inflammation is a condition associated with blood vessel inflammation caused by the overexpression of pro-inflammatory cytokines involved in vascular inflammation. Atherosclerosis is characterized by chronic inflammation of the vascular wall.
Chronic vascular inflammation has been found to cause historical changes in the blood vessel walls, leading to blood vessel wall thickening, weakening, narrowing, or scarring on orchestrating blood flow restriction, resulting in organ and tissue damage.
The most common symptoms of vascular inflammation are associated with reduced blood flow to supply nutrients and fluid to the body tissues, including fever, headache, fatigue, general aches, and pains, night sweats, rash, numbness, and weakness.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.
On findings, a potential compound for the treatment of acute vascular inflammation researchers evaluated the anti-inflammatory activity, and the cytotoxic effect of a novel chemically modified, non-carbonyl compound enriched Curcuma longa L. (C. longa) extract (CMCE).
According to the tested analysis, CMCE at the concentration of 1 or 10 μg/mL at 14 h, significantly decreased LPS (50-100 ng/mL) induced production of pro-inflammatory cytokines including TLR4 expression in THP-1 cells, human, and mouse whole blood.
In THP-1 cells, CMCE inhibited the expression of IRAK1, which plays a critical role in initiating an innate immune response against foreign pathogens, MAPK is involved in directing cellular responses to a diverse array of stimuli.
CMCE (30, 100, and 300 mg/kg; 10 days p.o.) pre-treated and LPS (10 mg/kg) in Swiss mice exhibited attenuated plasma TNF-α, IL-1β, nitrite, aortic iNOS expression, and vascular dysfunction associated with the production of pro-inflammatory cytokines.
In HL-60 cells., CMCE. exerted cytotoxic effects through cell cycle arrest on the Sub-G1 phase, increased apoptotic cells, loss of mitochondrial membrane in the cancer cells, and activation of cascade associated with pro-apoptosis.
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of vascular inflammation, pending the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A Standardized Chemically Modified Curcuma longa Extract Modulates IRAK-MAPK Signaling in Inflammation and Potentiates Cytotoxicity by Rana M1, Maurya P1, Reddy SS1, Singh V1, Ahmad H2, Dwivedi AK2, Dikshit M1, Barthwal MK. (PubMed)
(2) Curcumin: An Effective Inhibitor of Interleukin-6 by Ghandadi M1, Sahebkar A. (PubMed)
Subscribe to:
Posts (Atom)