#Herbal #Turmeric Inhibits Human Papillomavirus and Squamous Carcinoma Cells In Vitros, Researchers Say

By Kyle J. Norton

Cancer is a group of chronic diseases associated with cell growth disorderly in the tissue of some specific organ. Depending on the grade and stage, most cases of cancer in the advanced stage have been found to induce a higher mortality rate compared to cancer diagnosed in the localized stage.

Head and neck cancer is a group of cancers that starts in the cell on the surface of the inner lining of the mouth, nose, throat, larynx, sinuses, or salivary glands.

Squamous cell carcinoma is cancer arising from the squamous cells found in the outer layer of skin and in the mucous membranes, which are the moist tissues that line body cavities.

Head and neck squamous cell carcinoma (HNSCC) develops in the mucous membranes of the mouth, nose, and throat.

Head and neck squamous cell carcinoma (HNSCC) epidemiologically ahs have been found to spread to the lymph nodes or lungs. More than 90% of the head and neck cancer diagnosed are squamous carcinomas.

Symptoms of head and neck cancer may include a lump or sore that does not heal, a sore throat that does not go away, trouble swallowing, or a change in voice.

According to the statistics provided by the Western General Hospital, squamous cell cancer of the head and neck is common worldwide accounting for 4% of all cancers in the United States and 5% in the United Kingdom.


The exact causes of head and neck squamous cell carcinoma (HNSCC) are unknown. However, geographically, smoking tobacco, drinking alcohol, and long-term poor diet are essential risk factors in the West compared to risk factors of chewing betel or areca nuts, smoking bidis, and taking snuff are essential in the Indian subcontinent.

More importantly, the genetic preposition of genome 9p21, which may indicate the loss of a gene that suppresses tumors accounts for a total of 70% of all cases.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, and wound healing agent, and to treat flatulence, bloating, appetite loss, ulcers, eczema, inflammations, etc.

In finding a potential ingredient for the treatment of head and neck cancer, researchers examined the effect of curcumin on head and neck squamous cell carcinoma (HNSCC) using a panel of cell lines with and without human papillomavirus (HPV+, HPV-).

According to the tested differentiation, curcumin treatment of HNSCC cell lines not only interfered with RNA of Skp2, which causes cancer tumorigenesis and radiation tolerance but also induced concomitant accumulation of p21 and p27 associated with a cells cycle arrest in HPV+, HPV- cells.

Furthermore, curcumin inhibits cell viability and induces apoptosis in a dose-dependent manner in the tested cell line with and without human papillomavirus (HPV+, HPV-).


Moreover, curcumin treatment of HPV+ and HPV- cells resulted in apoptosis via the mitochondrial pathway of apoptosis and activation of caspases that play a critical role in programmed cell death.

Additionally, the inhibition of HPV+ and HPV- cells by curcumin was also found to suppress the expression of poor prognostic markers such as XIAP, and cancer survival such as cIAP1, and cIAP2.

More importantly, co-treatment of HNSCC cells with curcumin and cisplatin potentiated inhibition of cell viability and apoptotic effects.

Based on the findings, researchers wrote in the final report, "These data suggest an important function for curcumin, acting as a suppressor of oncoprotein Skp2 in squamous cell carcinoma cells in both HPV+ and HPV- cells".


Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of HNSCC, pending the confirmation of the larger sample size and multicenter human study.


Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin-Mediated Degradation of S-Phase Kinase Protein 2 Induces Cytotoxic Effects in Human Papillomavirus-Positive and Negative Squamous Carcinoma Cells by Khan AQ1, Siveen KS1, Prabhu KS1, Kuttikrishnan S1, Akhtar S1, Shaar A1, Raza A2, Mraiche F3, Dermime S2, Uddin S. (PubMed)
(2) TriCurin, a novel formulation of curcumin, epicatechin gallate, and resveratrol, inhibits the tumorigenicity of human papillomavirus-positive head and neck squamous cell carcinoma by Piao L1,2, Mukherjee S3,4, Chang Q4,5, Xie X1,2, Li H6, Castellanos MR7, Banerjee P3,4, Iqbal H1,2, Ivancic R1,2, Wang X1,2, Teknos TN1,2, Pan Q. (PubMed)
(3) Squamous cell carcinomas of the head and neck by R J Sanderson, consultant otolaryngologist and J A D Ironside, consultant clinical oncologist. (PMC)

#Healthyfood #Broccoli Processes Anti-Depression Activities, Researchers Say

By Kyle J. Norton

Depression is a common and serious psychological illness, that affects the physical and mental functions of patients, including the patient's feelings, thinking, and actions.

Some patients with depression may feel sadness and/or a loss of interest in activities once enjoyed.

There is no exact cause of depression. Changes in hormone levels, medical conditions, stress, grief, or difficult life circumstances that initiate the change of brain chemistry in inducing depressive syndrome are some of the most prevalent factors found in patients with depression.

The most common symptoms of depression include sadness, hopelessness, guilt, change of mood, and loss of interest in friends, family, favorite activities, and sex.

In severe case, some patients with depression also experience cognitive symptoms of trouble concentrating, making decisions, remembering and thoughts of harming his or herself.

According to the statistics provided by the Anxiety and Depression Association of Americans, major depressive disorder is the leading cause of disability in the U.S. for ages 15 to 44.3, affecting more than 16.1 million American adults, or about 6.7% of the U.S. population age 18 and older.

Conventionally, selective serotonin reuptake inhibitors (SSRIs) are the primary medication for the treatment of depression due to its relatively lower side effects compared to depressants. Other types of antidepression medication may include serotonin-norepinephrine reuptake inhibitors (SNRIs), typical antidepressants, and monoamine oxidase inhibitors (MAOIs).

Dr. Steven S. Clevenger and colleagues in examining the role of selective serotonin reuptake inhibitors in the relapse risk of major depressive disorder wrote, "According to the included studies, the relapse risk in adults was lower when SSRIs were combined with psychotherapy".

And, " the combination of SSRIs and cognitive behavioral therapy may effectively reduce relapse. Escitalopram appeared to yield better results and fewer side effects than did other SSRIs or SNRIs".
On finding a potent compound that process depressant-like activity, researchers examined the effects of Sulforaphane (SFN), an isothiocyanate compound derived from broccoli on inflammation-related depressive symptoms.

On lipopolysaccharide, (LPS, 0.5 mg/kg) induced depression-like behavior in mice, pretreatment SFN showed a significant effect in the blockage of the increase in the production of pro-inflammatory cytokine (tumor necrosis factor-α (TNF-α)) level and an increase in microglial activation of the brain associated with the inflammatory response by increasing the expression anti-inflammatory cytokine IL-10.

Activation of microglia is a hallmark of brain diseases.

In the tail suspension test and forced swimming test, immotility caused by the LPS of the tested mice was also attenuated by the injection of SFN.

Degeneration of cognition in the brain caused by the alternation of the density of the proteins associated with the brain functioning due to the LPS was also restored by the SFN.

More importantly, dietary intake of 0.1% glucoraphanin (a glucosinolate precursor of SFN) food in juveniles and adolescents has been found to prevent the risk of LPS-induced depression-like behaviors and dendritic spine changes in the brain regions in adulthood.

In other words, SFN isolated from the rich broccoli sprout exhibited depressant-like activity that was attributed to the anti-inflammatory property.

Based on the findings, researchers said, "Supplementation of SFN-rich broccoli sprout could be a prophylactic vegetable to prevent or minimize the relapse by inflammation in the remission state of depressed patients".

Taken altogether, broccoli sprouts rich in SFN may be considered a functional food for the treatment of depression, pending the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation by Zhang JC1, Yao W1, Dong C1, Yang C1, Ren Q1, Ma M1, Han M1, Wu J1, Ushida Y2, Suganuma H2, Hashimoto K. (PubMed)
(2) The role of selective serotonin reuptake inhibitors in preventing relapse of major depressive disorder by Steven S. Clevenger, Devvrat Malhotra, Jonathan Dang, Brigitte Vanle, andWaguih William IsHak. (PMC)

Healthyfood #Lentil's #Lectins improve the #ImmuneFunctioning, Scientists Show

By Kyle J. Norton

Lentil may have a profound and positive effect in modulating the immune response in the acute phase of infection, some scientists suggested.

Lentil is a type of pulse and tiny legume that can be cooked quickly and is rich in protein and fiber, belongings the genus Lens of the Fabaceae family, native to the Middle East.

The immune response is a natural reaction of the immune system to protect our body against the invasion of foreign substances.

In the acute phase of infection, the immune system initiated the production of proinflammatory Th1 cytokines in activated interleukin-12 (IL-12) and gamma interferon (IFN-γ) and other pro-inflammatory factors such as TNF beta in response to detect, engulf and destroy pathogens and apoptotic cells through macrophages.

These activities played an important in inducing apoptosis and reducing proliferation of bacteria or viruses by attaching to the surface of the injured cells to initiation of an alternation. however, overproduction of pro-inflammatory expression may indeed cause substantial adverse effects in tissue destruction, and, in some cases, shock and death.

Type 1 T helper (Th1) in response to tissue damage and injury also activated macrophages that are responsible for cell-mediated immunity and phagocyte-dependent protective activity.

In the concerns of lectins, adverse effects may pose a potential threat to consumers due to their capacity to induce histamine release from basophils, after investigating over 16 common dietary products containing lectins researchers found that most plant lectins induce human basophils to produce interleukin 4 (IL-4) an anti-inflammatory cytokine, which plays an important role in stimulated secretion of T cells and IL-13 another cytokines works conjunction with IL-4 in promoted the expression of T helper 2 (Th2) responses and regulation of Immunoglobulin E (IgE) synthesis.

All these expressed a significant effect of dietary lectin in reduced overexpression of pro-inflammatory factors in the immune system during the acute phase of infection in induced further cell damage and death in the infectious site through secretion of anti-inflammatory cytokines without decreasing the immune protective activities.

Truly, further examination also found that concanavalin A, lentil lectin, phytohemagglutinin, , triggered basophils to release IL-4 at concentrations of up to 1 ng/10(6) basophils which in turn orchestrated the release of IL-13 and histamine and levels of IL-4 and IL-13 release reached a maximum after 4-6 h and more than 18 h, after injection, respectively.

These activities demonstrated a significant effect of lentil lectin in inducing early IL-4 required to switch the immune response towards a Th2 response and type I allergy, involving immunoglobulin E (IgE)–mediated release of histamine and other mediators from mast cells and basophils.

Indeed, the relative balance between Th1 and Th2 cytokines appears crucial, as Th1 cells activated immune response during the early stage of bodily injury or damage through evoking cell-mediated immunity and phagocyte-dependent inflammation, in stimulated production of several pro-inflammatory cytokines such as interferon (IFN)-gamma, interleukin (IL)-2 and tumor necrosis factor (TNF)-beta which may also cause damage to the cell of the infectious region, leading to permanently additional damage to the tissues and Th2, under response to overexpression of pro-inflammatory cytokines stimulated the production of IL-4, IL-5, IL-6, IL-9, IL-10, and IL-13 of anti-inflammatory cytokines in evoked strong antibody responses (including those of the IgE class) and eosinophil accumulation, and inhibited several functions of phagocytic cells as indicated above.

Taken together, Lentil lectin may have an anti-inflammatory effect in reducing the overexpression of pro-inflammatory factors in the initiation of symptoms of fever, headache, swelling, redness, loss of appetite, and muscle stiffness through activating the production of anti-inflammatory cytokines.



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca







Author Biography
Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


Sources
(1) Role of Th1 and Th2 Cytokines in Immune Response to Uncomplicated Plasmodium falciparum Malaria by Donato Torre,1,* Filippo Speranza,1 Massimo Giola,1 Alberto Matteelli,2 Roberto Tambini,1 andGilberto Biondi1(PMC)
(2) Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils by Haas H1, Falcone FH, Schramm G, Haisch K, Gibbs BF, Klaucke J, Pöppelmann M, Becker WM, Gabius HJ, Schlaak M.(PubMed)
(3) T-cell subsets (Th1 versus Th2) by Romagnani S1(PubMed)

#Herbal #AloeVera Protects the Neurons Against the Onset of #NeurologicalDiseases, According to Studies

By Kyle J. Norton

A study from a renowned institute suggested that Aloe arborescens may be a potential neuroprotective agent against copper-induced neurobehavioral features of Parkinson's disease.

Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan, used in herbal medicine in treating many kinds of disease, including wounds, burn to heal, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc.

According to the joint study led by the Cadi Ayyad University, Neurosciences, Pharmacology, and Environment Unit, Aloe Vera expressed altered dopaminergic innervations associated with neurological disorders, Parkinson's disease following Cu intoxication.

Dr. Abbaoui A, the lead researcher said, " (Aloe arborescens gel )AEAAG administration to Cu intoxicated rats showed a noticeable beneficial effect; this potential was featured by a complete recovery of the (tyrosine hydroxylase)TH expression (in the regulation of dopamine Synthesis)
and locomotor behavior deficiencies in the intoxicated rats".


Aloe-emodin, an active compound found in Aloe Vera leaf, also exhibited neuroprotective effects by attenuated scopolamine(a medication used to treat motion sickness and postoperative nausea and vomiting)-induced cognitive deficits via inhibiting acetylcholinesterase (AChE) activity involved breaking down of neurotransmitter and modulating oxidative stress.

The study also insisted the antioxidant activities inhibited significantly extracellular intracellular reactive oxygen species (ROS) production to prevent cytotoxicity in patients with Alzheimer's disease(AD).

In fact, The neuroprotective expression of Aloe Vera polysaccharide is found to downregulate(caspase-3 expression) the process of apoptotic cell death in the brain during injury.

Taking together, Aloe Vera exerted a neuroprotective effect in reducing the risk of dementia through many aspects, including free radical inhibition, anti-cytotoxicity, and chemical toxicity..... but human trials are necessary to confirm its validity.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
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Sources
(1) Neuroprotective potential of Aloe arborescens against copper-induced neurobehavioral features of Parkinson's disease in rats by Abbaoui A1, Hiba OE2, Gamrani H3. (PubMed)
(2) Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and H₂O₂-induced cytotoxicity in PC12 cells by Tao L, Xie J, Wang Y, Wang S, Wu S, Wang Q, Ding H.(PubMed)
(3) Effect of aloe polysaccharide on caspase-3 expression following cerebral ischemia and reperfusion injury in rats by Lu ZQ1, Deng YJ, Lu JX.(PubMed)

#Antioxidant 3,3'-#Diindolylmethane Inhibits the Onset of #ColorectalCancer, Researchers Show

By Kyle J. Norton

Colorectal cancer is a medical and chronic condition caused by irregular cell growth in the colon or rectum.
Colorectal cancer is one of the slowest growth of cancer. Therefore, Most cases of colorectal cancer are discovered in the later stage, causing a high rate of mortality.

According to the study, at the advanced stage, the median survival of patients is 24 months (range 16–42). The one-year and 2-year survival rate is 65% and 25%, respectively.
Most cases of colorectal cancer start in the cells on the surface of the inner lining of the colon or rectum. At the early stage, due to the small size of the tumor, most patients are asymptomatic.

However, at the advanced stage, the oversize tumor may suppress the nearby blood vessels and nerve cells, leading to persistently severe bleeding and pain.

Patients at this stage may also experience symptoms of a change in bowel habits, including diarrhea or constipation or consistency of the stool, that lasts longer than four weeks.

If you experience some of the aforementioned symptoms, please make sure that you check with your doctor immediately to rule out the possibility.

The exact causes of colorectal cancer are not identified. Out of many risk factors associated with the onset of the disease, aging may be one of the major causes, as most cases of colorectal cancer are diagnosed in adults over the age of 50, and the risk increases with age.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, kale, etc.

Researchers on finding a potential and natural compound for the treatment of colorectal cancer examined the diindolylmethane (DIM) effect on cyclin D1, which was aberrantly overexpressed in various cancer cells and tumors.

Where Cyclin D1 is a protein associated with the progression of cancer through the G1 phase of the cell cycle in cellular division.

Injection of DIM interfered the Cyclin D1 function in the promotion of colorectal cancer proliferation, without affecting the cyclin D1 mRNA expression.

The results suggested that DIM modulated cyclin D1 expression by controlling the levels of protein synthesized from its mRNA.

In other words, DIM inhibited cyclin D1 by triggering ER stress in human colorectal cancer cells through decreasing protein synthesis and growth arrest in the G1 phase of the cell cycle.

Additionally, in order to reveal more information about DIM anti-colorectal cancer properties, researchers investigated the effect of DIM on the migratory and invasive activities of the human colorectal cancer cell lines DLD-1 and HCT116.

Injection of DIM significantly inhibited the migratory ability of the DLD-1 and HCT116 cells at 24 and 48 hours.

DIM also significantly inhibited the invasion rate of the DLD-1 and HCT116 cells in a dose-dependent manner.


Following DIM treatment, researchers found that DIM anti-colorectal cancer property was associated with attenuating the mRNA expression levels of urokinase receptor and matrix metalloprotease 9 (MMP9) involved cancer cell adhesion and enhancing the expression of tumor-suppressive mRNA.

Furthermore, DIM significantly reduced the mRNA and protein levels of FOXM1 in the promotion of cell division or proliferation in DLD-1 and HCT116 cells.

Based on these results, Dr.Jin H, the lead scientist in the summary of the report, wrote, "DIM can influence the cell migratory and invasive properties of human colorectal cancer cells and may decrease the invasive capacity of colorectal cancer through downregulation of uPA and MMP9 mediated by suppression of the transcription factor FOXM1".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of colorectal cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-diindolylmethane downregulates cyclin D1 through triggering endoplasmic reticulum stress in colorectal cancer cells by Zhang X1, Sukamporn P2, Zhang S3, Min KW4, Baek SJ. (PubMed)
(2) FOXM1-mediated downregulation of uPA and MMP9 by 3,3'-diindolylmethaneinhibits migration and invasion of human colorectal cancer cells by Jin H1, Li XJ1, Park MH2, Kim SM. (PubMed)
(3) Survival of untreated advanced colorectal cancer patients by G.P. STATHOPOULOS, (PMC)

#Antioxidant #Bromelain Exhibits Enzymatic Debridement in #ChronicWound, Researchers Say

By Kyle J. Norton

A chronic wound is a wound that does not heal within a predictable period of time.
It may be a result of the interruption of the stage of wound healing or damage of the blood vessels that have a function in providing necessary conditions to promote the closure of the wound as seen in a diabetic leg ulcer.

In other words, any wound that does not heal within 3 months is considered a chronic wound.

According to the statistics provided by the study "An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds", approximately, 2% of the population in developed countries suffer from chronic wounds.

Additionally, every year, more than 305 million cases of acute, traumatic, and burn wounds are treated globally.

Believe it or not, chronic and acute wound affects more than nine times of people around the world compared to those living with cancer.

Some researchers suggested that pressure, trauma, and/or lower extremity wounds, increased bacterial load, interruption of the stage of wound healing including excessive proteases, degraded cell surface structures, and inappropriate treatment are considered the most potent causes of the conditions.

More precisely, if we can protect all stages of wound healing without interruption, the chronic wound can be preventable.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent for the treatment of pains, strains, muscle aches, and pains and to ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural compound for the treatment of chronic wounds, researchers examined the efficacy of bromelain-based enzymatic debridement of chronic wounds.

The study included 24 patients with chronic wounds of different aetiologies.

According to 2 consecutive single-arm studies assessing the enzymatic debridement efficacy in 2 medical centers, all wounds achieved an average of 68% ± 30% debridement in an average of 3.5 ± 2.8 enzymatic debridement 4-hour sessions.

17/24 patients showed responding wounds (venous, diabetic, pressure, and post-traumatic aetiologies) of an average of 85% ± 12% debridement in 3.2 ± 2.5 applications, compared to 7/24 patients with no response.

There were no adverse effects reported by the patients. Based on the findings, researchers wrote, "These preliminary results indicate the potential safety and efficacy of bromelain-based enzymatic debridement in chronic wounds".

In vitro, according to the results of two soft tissue healing--fibroblasts and microvascular endothelial cells--were used as mono- and co-culture with bromelain, bromelain attenuated endothelial cell, and fibroblast proliferation moderately.


The inhibition of cell proliferation was not associated with cell apoptosis but with cell cycle arrest in the G0 phase.

In the comparable test, bromelain did not reduce endothelial cell migration. whereas fibroblast migration was clearly slowed down.

In other words, bromelain displayed a significant decrease of myofibroblasts under both normoxic (from 19 to 12 %) and hypoxic conditions (from 22 to 15 %) coincident with higher levels of anti-inflammatory expression.

Based on the findings, researchers wrote, "Usage of bromelain as a therapeutic drug for chronic human wounds thus remains a very promising concept for the future".

Taken altogether, bromelain used alone or combined with other remedies may be considered supplements for the prevention and treatment of chronic wounds, pending the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain-based enzymatic debridement of chronic wounds: A preliminary report by Shoham Y1, Krieger Y1, Tamir E2, Silberstein E1, Bogdanov-Berezovsky A1, Haik J3, Rosenberg L. (PubMed)
(2) Bromelain down-regulates myofibroblast differentiation in an in vitro wound healing assay by Aichele K1, Bubel M, Deubel G, Pohlemann T, Oberringer M. (PubMed)

#Phytochemical #Indole3Carbinol Found in #CruciferousVegetables Exhibit Anti #Cancer Activities, Scientists Suggest

By Kyle J. Norton

Intake of cruciferous vegetables may reduce the risk of cancers, some scientists suggested.
Cancers are a group of chronic and medical diseases characterized by irregular cell growth in the body tissue caused by the change of DNA transcription of healthy cells.

Normal cells have the division of a limited cell cycle compared to a cancerous cell which can grow unlimitedly.

If an invasive tumor is growing too large, it can suppress the nerves and muscles surrounding them, leading to persistent pain and other symptoms, depending on the location.

The exact causes of cancer are unknown. Researchers do not know why people with the same health condition, are susceptible to the onset of the diseases, while others do not.

However, an unhealthy diet, such as eating processed foods and fast foods, and lifestyles such as smoking, being overweight, physical inactivity, and excessive alcohol drinking are some of the major causes of cancer.

Truly, according to the article written by the Telegraph, an unhealthy lifestyle is responsible for half of the onset of cancers. And overweight or obese is a cause of 12 types of cancer.

Other prevalent risk factors of cancer are genetic mutation inherited from the parents, environment toxic chemicals, radiation, virus, hormone imbalance,... and chronic inflammatory diseases.

Besides the general symptoms such as lumps, loss of appetite, fatigue, tiredness, and unintended weight loss, patients with cancers also experience some symptoms totally depended on the location, types, and grade of infected tissues and organs,

Cruciferous vegetables are a group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.


According to a recent study, indole-3-carbinol (I3C), a substance present in cruciferous vegetables suppressed the proliferation of different tumor cells, including those isolated from breast, prostate, endometrium, and colon cancers, in vitro.

Dr. Popolo A, the lead author suggested, the effect of the chemical compound in the treatment of various cancers may be attributed to the interference of cancer cell cycle division and expression of a diverse set of genes involved in cell differentiation.

Dr. Aggarwal BB and Dr. Ichikawa H. in the additional examination of the function of indole-3-carbinol (I3C) also found that application of the phytochemical also inhibited DNA-carcinogen abducted and new blood vessels involved cancer cell survival formation, suppressed free-radical production, and stimulated 2-hydroxylation of estradiol in the reduction of cell proliferative and estrogenic activity and

Furthermore, indole-3-carbinol and its derivatives not only exerted anti-cancer effects by restoring original gene formation but also inhibited free radicals production, ... but also interfered with the cancer cell cycle division phase to induce apoptosis.

Other chemical compounds found in the cruciferous vegetables, shown to possess potent antitumor and chemopreventive activity are sulforaphane (SFN), an isothiocyanate, and Allyl nitrile (3-butene nitrile).

Taking together, there is no doubt, cruciferous vegetables have exhibited anticancer activities, through many aspects.

Intake of cruciferous vegetables regularly is associated with reduced risk and treatment of various types of cancer.

However, further data collection on large example size and multi-center studies performed with human consumption of the whole food of cruciferous vegetables during the course of the disease will be necessary to complete the picture of cruciferous vegetables' anti-cancer possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Two likely targets for the anti-cancer effect of indole derivatives from cruciferous vegetables: PI3K/Akt/mTOR signaling pathway and the aryl hydrocarbon receptor by Popolo A1, Pinto A1, Daglia M2, Nabavi SF3, Farooqi AA4, Rastrelli L5. (PubMed)
(2) Molecular targets and anticancer potential of indole-3-carbinol and its derivatives by Aggarwal BB1, Ichikawa H.(PubMed)
(3) Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells by Liu KC1, Shih TY1, Kuo CL2, Ma YS3,4, Yang JL2, Wu PP5, Huang YP6, Lai KC7,8, Chung JG9,10. (PubMed)
(4) Allyl nitrile: Toxicity and health effects by Tanii H1.(PubMed)