#Healthyfood #Cabbage, in Reducing the Risk of #CervicalCancer, Studies Suggest

By Kyle J. Norton

Cervix formed part of the reproductive organ, is the lower part of the uterus that opens at the top of the vagina.

The cervix acts as a transition area (squamous columnar epithelium) for the vaginal lining (squamous epithelium) to the uterus (columnar epithelium) to host the development of the fetus.

Cancer is the class of diseases associated with cell growth disorderly and uncontrollably due to the alternation of DNA.

Cervical cancer is a malignant neoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cells DNA.

Researchers do not know what causes cervical cancer. Most cases of cervical cancer start in the cell on the surface of the inner lining tissue of the cervix. At this stage, most women with cervical cancer do not experience any symptoms.

At the advanced stage, invasive cancer can induce symptoms of abnormal bleeding, pain during sexual intercourse, increased vaginal discharge. If the tumor has suppressed the nearby nerve cells, cervical cancer can also cause localized severe pain.

According to the American Cancer Society's, in 2014, 12,360 new cases of invasive cervical cancer will be diagnosed with the death of 4,020 patients.

Epidemiological also suggested that HPV infection, sexual activity, smoking, and giving birth many times. Infection with the human immunodeficiency virus (HIV, a history of sexually transmitted infections (STIs), and long-term use of oral contraceptives are some prevalent risk factors for cervical cancer.

The risk of cervical cancer is also higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem that is crowded with a mass of green leaves, but in some varieties, it may be red or purplish.

With an aim to find a natural food that reduces the risk of malignant tumors, researchers investigated the activity of Indole-3-Carbinol (I3C), a phytochemical (derived from cabbage, and other cruciferous vegetables) on the reduction of cervical intraepithelial neoplasia (CIN) and its progression to cervical cancer.

According to the tested assays,
* In vitro, I3C inhibited the diminished PTEN expression during the progression from low-grade to high-grade cervical dysplasia in humans,

In other words, the gene associated with tumor-suppressing activity not only was significantly inhibited before the onset of cervical cancer in patients with high-grade cervical dysplasia but also play a critical role in the initiation and progression of cervical intraepithelial neoplasia (CIN).

* In vivo, K14HPV16 transgenic mice model induced cervical cancer exerted overexpression of hormone estrogen.

* Dietary I3C in the tested models increased PTEN expression in the cervical epithelium of the transgenic mouse, to reduce the risk of development of cervical cancer.

Taken altogether, cabbage processed with abundantly antioxidant I3C, may be considered a functional remedy for the prevention of cervical cancer, pending the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Indole-3-carbinol prevents PTEN loss in cervical cancer in vivo by Qi M1, Anderson AE, Chen DZ, Sun S, Auborn KJ. (PubMed)

#Herbal #Arnica in the Inhibition of the #Symptoms of #Osteoarthritis With No Side Effects, Scientists Reveal

By Kyle J. Norton

Arnica may have a substantial and positive effect on reduced risk and treatment of osteoarthritis, some scientists suggested.

Osteoarthritis (OA), a form of arthritis, is a chronic condition characterized by wear and tear on a joint due to aging, affecting over 25 million people in the United States alone.

The University of Porto Medical School suggested that one must understand the differences in prevalence and incidence estimates of osteoarthritis (OA), according to case definition, in the knee, hip, and hand joints(3).

The most common symptoms of osteoarthritis are aching pain, stiffness, or difficulty of moving the joint or joints.

The pain usually gets worse in a change of weather, at night, and in advanced diseases, the pain can occur even at rest.

Today management of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments.

An unhealthy diet that cause nutrient deficiency and overload, damage of cartilage, a joint injury that did not heal properly, overuse, and autoimmune rheumatoid arthritis also have potential effects on the increased prevalence of osteoarthritis.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, and used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is a process of repairing the damage to the skin, tissues, organs, etc.

In a randomized, double-blind study of 204 patients to investigate the effect of ibuprofen (5%) and Arnica (50 g tincture/100 g, DER 1:20), as gel preparations in patients with radiologically confirmed and symptomatically active osteoarthritis of interphalangeal joints of hands, researchers found that after 21 days of treatment, group treated with Arnica exerted a significant effect in relieve and function of the joints of hands similar to group treated with the conventional medicine.

4.8% in the Arnica group reported some tolerant adverse effects compared to 6.1% in the group treated with ibuprofen.

After taking into account other co and con factors, Dr. the lead researcher said, "Our results confirm that this preparation of Arnica is not inferior to ibuprofen when treating osteoarthritis of the hands".

In other to confirm the effect of Arnica as a form of functional food for the treatment of osteoarthritis, scientists at the Valens Clinic for Rheumatism conducted a study of topical application of Arnica montana fresh plant gel twice daily, in 26 men and 53 women with mild to moderate osteoarthritis (OA) of the knee.

According to the study, treatment after 3 and 6 weeks demonstrated a strong improvement of the median total scores on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), used by health professionals with a proprietary set of standardized questionnaires to evaluate the condition of patients with osteoarthritis, including knee and hip, including pain, stiffness, and physical functioning of the joints.

Furthermore, in regard to the symptoms expression of osteoarthritis, the application of the herbal preparation exerted a significant reduction of pain, and stiffness, observed by the pain and stiffness score.

A score of the mean of function subscales also showed significant reductions at these time points.

The physical function subscale found in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is considered more consistent with stronger test-retest reliability compared to the pain score with some inconsistencies across the studies.

However, local tolerant adverse effects were reported in 7.6 % of patients who attended the study with one patient with an allergic reaction.

Interestingly, at the end of the study, 87% rated the tolerability of the gel as "good" or "fairly good," and 76% would use it again.

These results indicated that topical application of Arnica montana gel for 6 weeks alleviated symptoms of osteoarthritis in all aspects and may be considered as a well-tolerated, and effective treatment of mild to moderate OA of the knee.

Taken together, as a topical herbal medicine, Arnica may be considered a functional food for attenuated symptoms and treatment of osteoarthritis.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Choosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomized, double-blind study by Widrig R1, Suter A, Saller R, Melzer J.(PubMed)
(2) Arnica montana gel in osteoarthritis of the knee: an open, multicenter clinical trial by Knuesel O1, Weber M, Suter A.(PubMed)
(3) The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review by Pereira D1, Peleteiro B, Araújo J, Branco J, Santos RA, Ramos E.(PubMed)relationships by Schomburg C1, Schuehly W, Da Costa FB, Klempnauer KH, Schmidt TJ(PubMed)

#Phytochemical #Lycopene Reduces the Risk of #ProstateCancer, According to studies

By Kyle J. Norton

Prostate cancer is a medical and chronic condition caused by the growth of cells irregularly in the tissue of the prostate.

The prostate gland wrapped around a tube (the urethra), is a gland of the male reproductive system found in front of the rectum and just below the bladder with a function that produces some of the semen that carries sperm.

Most cases of prostate cancer start in the cells on the surface of the inner lining of the prostate gland.


According to the statistic provided by the Canadian Cancer Society, prostate cancer is the third most common cancer among Canadian men and the 3rd leading cause of death from cancer in men in Canada.

In 2017, approximately 21,300 men were diagnosed with prostate cancer, accounting for 21% of all new cancer cases in men.

Furthermore, approximately 1 in 7 Canadian men will develop prostate cancer during their lifetime and 1 in 29 will die from it.

The most common symptoms of prostate cancer are
* Frequent urination
Patients urinate much time than usual for over periods of 1 year or 2, as a result of enlarged tumors that press against the bladder.

* Urgency
A desire to pass urination more urgency as a result of the enlarged tumor pressing against the bladder.

* Dribbling after finished passing urine, urine continues to dribble as a result of the enlarged prostate tumor.

* Hesitancy
Having to wait a long time for the urine stream to start as a result of cancer has narrowed the urethra.

* Blood in the urine
Prostate cancer may have damaged any part of the urinary tract.

* Painful urination and ejaculation
As cancer has grown large, it interferes with the function of the urethra

* Blood in the semen
As cancer has grown large enough to damage the walls of the urethra.

* Lower back pain
As a result of the enlarged prostate tumor has pressed on spinal nerves.

* New-onset erectile dysfunction (impotence)
Prostate cancer has interfered with blood vessels, responding to the erection.

If you have experienced some of the aforementioned symptoms persistently, please check with your doctor to rule out the possibility.

The 5 years of prostate cancer diagnosed at the localized stage are 100%.

Lycopene is a phytochemical in the class of carotenoids, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world's diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

With an aim to find a potential and natural compound for the treatment of prostate cancer(PCa), researchers investigated the association between prostate cancer and lycopene.

42 studies were included in the analysis including included 43 851 cases of PCa reported from 692 012 participants after searching the eligible studies published before 1 December 2016 and identified from PubMed, Web of Science, and the Cochrane Library, both dietary intake and circulating concentrations of lycopene were significantly associated with reduced PCa risk.

Furthermore, lycopene showed a significant linearly dose response in reduced risk of prostate cancer. In other words, for an additional 2 mg of lycopene consumed, the risk of prostate cancer is reduced by 1%.

Compared to dietary lycopene, an additional 10 μgdl-1 of circulating lycopene in the blood of the linear and nonlinear models decreased the PCa risk by 3.5 to 3.6%.

Observation of lycopene effect in advanced PCa, the secondary metabolite also demonstrated a trend for protection against PCa aggressiveness.

Based on the findings, researchers wrote," Our data demonstrate that higher dietary and circulating lycopene concentrations are inversely associated with PCa risk. This was accompanied by dose-response relationships for dietary and circulating lycopene".

According to another meta-analysis conducted by the Zhongnan Hospital of Wuhan University in the search, eligible studies published in English up to April 10, 2014, from Pubmed, ScienceDirect Online, Wiley online library databases, and hand searching,
* Higher lycopene consumption significantly lowered PCa risk.

* Higher lycopene consumption was linearly associated with a reduced risk of PCa and higher circulating lycopene levels significantly reduced the risk of PCa.

* However, the concentration of circulating lycopene between 2.17 and 85 μg/dL was linearly inversed with PCa risk compared to no linear association of any doses that are >85 μg/dL.


Collectively, researchers wrote, "Our novel data demonstrated that higher lycopene consumption/circulating concentration is associated with a lower risk of PCa".

Taken altogether, lycopene may be considered a supplement for the prevention and treatment of prostate cancer, pending the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Increased dietary and circulating lycopene are associated with reduced prostate cancer risk: a systematic review and meta-analysis by Rowles JL 3rd1, Ranard KM1, Smith JW1, An R2, Erdman JW Jr. (PubMed)
(2) Lycopene and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis by C

#Ashwagandha The Herbal Medicne Reduces the Onset of #Anxiety Induced by #ChronicStress, Scientists Suggest

By Kyle J. Norton

Chronic stress is the response to emotional pressure in demanding situations over a period of time, leading to the release of the hormone cortisol and adrenaline.
The most common factors associated with stress incidence include psychological pressures, such as work deadlines, and exams, high-pressure jobs, and financial difficulties.

Over time unresolved chronic stress can cause a wide range of symptoms and increase the risk of anxiety.

Anxiety disorder is a class of medical conditions associated with chronic worries and fear, leading to symptoms of a fast heart rate and shakiness.

Most people with anxiety may experience the feeling of nervousness in responding to events such as a problem at work, before taking a test, or before making an important decision.

According to the statistics, anxiety disorders are the most common mental illness in Canada, and approximately 1 in every 8 Canadians is affected by the illness. In other words, over 250,000 people in Canada suffer from anxiety.

The most common prevalent factors that induce the risk of the condition are, family history, gender (women are more likely diagnosed with the condition compared to men), chronic stress, people with traumatic life experiences and the use of substances are some prevalent risk factors of anxiety.

However, some researchers suggested moderate physical activity, mind-body practices of breathing exercises, yoga, and meditation have been found to reduce stress, a strong positive impact on anxiety.

The Anxiety and Depression Association of America wrote, "Whether, in good times or bad, most people say that stress interferes at least moderately with their lives. Chronic stress can affect your health, causing symptoms from headaches, high blood pressure, and chest pain to heart palpitations, skin rashes, and loss of sleep".

"Physical activity is a proven way to reduce stress. Regular participation in aerobic exercise has been shown to decrease overall levels of tension, elevate and stabilize mood, and improve sleep and self-esteem. Other effective methods include mind-body practices of breathing exercises, yoga, and meditation".

Ashwagandha also known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, the Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine for over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered an anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of symptoms associated with chronic stress, researchers examined the efficacy of a high-concentration full-spectrum extract of Ashwagandha roots in reducing stress and anxiety in adults who were under stress.

A total of 64 subjects with a history of chronic stress included were randomized to either the drug treatment group and were asked to take one capsule containing 300 mg of high-concentration full-spectrum extract from the root of the Ashwagandha plant or the placebo control group. twice a day for a period of 60 days.


Based on the results of the tested analysis, the treatment group received a high-concentration full-spectrum Ashwagandha root extract and showed a significant reduction in scores on all the stress-assessment scales on Day 60 compared to the placebo.

The serum cortisol levels were substantially reduced in the Ashwagandha group, compared to the placebo group.

According to the patient's reports, there are no serious adverse events reported during the experimental period.


In other words, the short-term application of the Ashwagandha plant at a high concentration not only reduced the levels of c stress but also stress-induced hormone expression of anxiety.

Based on the findings, researchers said, "a high-concentration full-spectrum Ashwagandha root extract safely and effectively improves an individual's resistance towards stress and thereby improves self-assessed quality of life".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention of anxiety induced by chronic stress, pending the result of a larger sample size and multicenter study


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's News, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera) by Pratte MA1, Nanavati KB, Young V, Morley CP. (PubMed)
(2) A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults by Chandrasekhar K1, Kapoor J, Anishetty S. (PubMed)
(3) Stress by the Anxiety and Depression Association of America

#Piperine, the Antioxidant Which Processes Anti-Metabolic Dysfunction Properties In Vivo, According to Studies

By Kyle J. Norton

Piperine may be considered a natural ingredient for the treatment of metabolic dysfunction in obese patients, some scientists suggested.

Piperine is a phytochemical alkaloid in the class of organosulfur compounds, found abundantly in white and black pepper, long pepper, etc.

Obesity is a medical condition characterized by excess body fat accumulated in the body over time.

While overweight is a condition of excess body weight relative to height.

According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of the American population is either overweight or obese, a leading cause of metabolic dysfunction.

In other words, obesity is a metabolic disorder that predisposes patients to numerous diseases which not only causes a financial burden to the healthcare system but also increases the reduction of quality of life of the patients.

Metabolic dysfunction is caused either by abnormal chemical reactions or disruption of chemical production in the body, altering the normal metabolic process.

Some researchers suggested that obesity's metabolic dysfunction may be a result of the liver or pancreas do not function properly due to fat accumulated in the organs.

There is no coincidence that the widespread obesity over the past several decades is correlated to the promotion of the Western diet. Some researchers firmly suggested that diet rich in saturated and trans fat, red meat, and processed foods and less in fruits and vegetables and whole grains is associated with the onset of obesity.

Dr. Bortolin RC, the lead scientist in the study to examine the metabolic parameters and gut microbiota changes in rats fed with the Western diet suggested: "diet, and not the obese state, was the major driving force behind gut microbiota changes" and "WD-fed rats developed obesity and obesity-related comorbidities independent of major alterations in gut microbiota composition (dysbiosis), whereas CAF-fed rats developed the greatest dysbiosis independent of obesity".

The result clearly stated that long-term intake of the Western diet induces metabolic syndrome and obesity. In other words, Obesity is not the cause of metabolic dysfunction.

On finding a natural ingredient or whole food for the prevention and treatment of widespread obesity-induced metabolic dysfunctions in the Western world, researchers examine the antimetabolic phytochemical Piperine isolated from the black pepper.

The randomized, double-blind, placebo-controlled, 8-week trial included the assessment of the efficacy of metabolic changes versus a placebo.

In a total of 86 overweight subjects selected to the study, 41 patients (2/14 F/M; age 43.7 ± 8.5; BMI 30.3 ± 3.5 kg/m(2)) were assigned to the supplemented group and 45 (29/16; age 40.7 ± 10.2; BMI 30.0 ± 2.7) to the control group.

At the end of 8 weeks, the supplement group showed a decrease in levels of a hormone produced by adipose cells that regulates energy balance by inhibiting hunger. High levels of leptin hormone are an indication of leptin resistance, found in overweight and obese patients.

The levels of a hormone associated with the stimulated appetite increased food intake and promoted fat storage also decreased in the supplement group. The hormone ghrelin is found abundantly in overweight and obese subjects.

Furthermore, the supplement group also showed a decrease of inflammation observed by the levels of C-reactive protein and an increased resting energy expenditure significantly, compared to the placebo.

Compared to the decreased significantly levels of adiponectin in the placebo, the supplement group also showed an increase in the hormone protein that regulates glucose levels as well as fatty acid breakdown.

These results suggested that the supplement group demonstrates a greater chance of metabolic dysfunction compared to the placebo.

In other words, introducing piperine into the overweight and obese diet might be useful for the treatment of obesity-related inflammatory metabolic dysfunctions.

Additionally, in order to understand the effect of piperine on overweight and obese insulin resistance, researchers evaluated the bioactive chemical activity in mice feeding a high-fat diet (HFD) for 13 weeks.

Before injecting the mice with piperine, researchers found that mice fed with high-fat diet display elevated plasma concentrations of insulin and glucose and hepatic lipid levels.

Administration of piperine (50 mg/kg body weight) only normalized the concentrations of insulin and glucose and hepatic lipid levels but also increased the levels of adiponectin and inhibited the protein which plays an important role in mediating lipogenesis, fatty acid oxidation and insulin signaling in the livers of mice.

In gene observation, piperine injection also increased the expression of the carnitine palmitoyltransferase 1 (CPT1) gene involved in the regulation of fatty acid oxidation in the liver, an indication of resist weight gain.

Dr. Choi S, the lead researcher suggested, piperine significantly decreased insulin resistance in mice fed with a high-fat diet by increasing the levels of adiponectin and activating the pathway associated with fatty acid oxidation.

Taken altogether, piperine may be considered a bioactive compound for the protection of overweight and obese against the inflammatory and metabolic dysfunctions and weight gain without inducing any side effects

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months' consumption of a combination of bioactive food ingredients in overweight subjects by Rondanelli M, Opizzi A, Perna S, Faliva M, Solerte SB, Fioravanti M, Klersy C, Cava E, Paolini M, Scavone L, Ceccarelli P, Castellaneta E, Savina C, Donini LM. (PubMed)
(2) Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice by Choi S, Choi Y, Choi Y, Kim S, Jang J, Park T.(PubMed)
(3) Piperine, an active principle from Piper nigrum, modulates hormonal and apolipoprotein profiles in hyperlipidemic rats by Vijayakumar RS, Nalini N.(PubMed)(4) A new animal diet based on a human Western diet is a robust diet-induced obesity model: comparison to high-fat and cafeteria diets in term of metabolic and gut microbiota disruption by Bortolin RC1, Vargas AR1, Gasparotto J1, Chaves PR1, Schnorr CE1, Martinello KB2, Silveira AK1, Rabelo TK3, Gelain DP1, Moreira JCF. (PubMed)

#Leeks, the #Healthyfood Which Processes #Anticancer Activities in Vitro

By Kyle J. Norton

Cancer is a group of medical and chronic diseases characterized by cell growth disorderly and uncontrollably in the tissue of specific organs in the body.

Over time, the alternative cells-induced tumor may become progressively worse and damage other healthy tissues, depending on the grade of the tumor.

At the later stage, the most invasive tumor can induce secondary metastasis by spreading to other organs in the body via lymph or blood.

According to the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some point during their lifetimes, according to the data from 2013–2015.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

The causes of cancer are unknown. age, excessive alcohol drinking, exposure to cancer causing-substances, diseases associated with chronic inflammation, unhealthy diet, hormone therapy, and use of immunosuppression are some of the prevalent factors involved in the onset of cancer.

However, most people with some of the aforementioned risk factors have never developed cancer.

Cancers are the second leading cause of death worldwide besides heart diseases.

The most common types of cancer in Canada include lung, colorectal, breast, and prostate cancers. And these 4 cancers account for half of all cancers diagnosed in Canada.

Believe it or not, 1/4 of cancers death are due to lung cancer.

Depending on the type of cancer, people with cancers may experience general and specific symptoms.
Some researchers suggested that the risk of cancers in obese individuals may correlate to the promotion of the Western diet over the past few decades.

Leek is a genius of Allium, belonging to the vegetable family vegetable Alliacaea, the same as onion and garlic. Leeks are easy to grow from seed and usually reach maturity in the autumn months, and have few pest or disease problems.

On finding a potential plant that processes anti-tumor growth activity researchers compared the anticancer properties of various sulfur and organic compounds like S-allyl mercaptocysteine, quercetin, flavonoids, and ajoene found on leek on cancer.

According to the analysis,
* These compounds with various mechanisms such as hindering the cell cycle, inhibiting signaling pathways, inducing apoptosis, and antioxidant activity interfere with diverse stages of formation, growth, differentiation, and metastasis of cancer cells.

* Similar to garlic and onion, other species such as leeks have exhibited anticancer activities, so that active natural molecules extracted from them might serve as possible anticancer agents.

Moreover, the study on anticancer effects of onion and leek extracts on MCF-7 human breast cancer cells cultured in complete media at 37 °C and subjected to different treatments that involved varying concentrations (10, 50, and 100 μg/mL) of onion and leek extracts for 24, 48, and 72 h of incubation suggested that * The water leek extract proved to be the most effective extract at 50 μg/mL, whereby it showed a significant inhibition ability due to the presence of anandamide A-β-D-glucopyranoside.

* Both extracts induced cell death probably was also associated with the presence of other bioactive compounds.

Taken altogether, leeks may be considered a functional food for the prevention and treatment of cancer, pending the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professional's Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Comparative Study of Onion (Allium cepa) and Leek (Allium ampeloprasum): Identification of Organosulphur Compounds by UPLC-QTOF/MS and Anticancer Effect on MCF-7 Cells by Zamri N1, Hamid HA. (PubMed)
(1) Allium vegetables for possible future of cancer treatment by Asemani Y1, Zamani N2, Bayat M1, Amirghofran Z. (PubMed)

#Antioxidant #Piperine Inhibits the Risk of #Hyperglycemia, According to Scientists

By Kyle J. Norton

Bioactive piperine may have a strong and positive effect in reducing the risk and treatment of hyperglycemia in the management of type 2 diabetes, according to the studies.

Piperine is a phytochemical alkaloid in the class of organosulfur compounds, found abundantly in white and black pepper, long pepper, etc.

Hyperglycemia is a condition of abnormally high blood sugar which is considered a hallmark sign of diabetes (both type 1 diabetes and type 2 diabetes) and prediabetes.

Hyperglycemia doesn't cause symptoms until glucose values are significantly elevated to the levels above 180 to 200 milligrams per deciliter (mg/dL), or 10 to 11 millimoles per liter (mmol/L). Most common symptoms of hyperglycemia include headaches, fatigue, blurred vision, hunger, confusion, and trouble with concentrating.

Diabetes is a chronic and medical condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

The disease is either caused by cells in the pancreas that died off or receptor sites clogged up by fat and cholesterol.

According to the statistic, in the US, approximately 30.3 million Americans, or 9.4% of the population, had diabetes. Approximately 1.25 million American children and adults have type 1 diabetes In 2015.

The disease is on the rise at an alarming rate. Most cases of hypoglycemia are the results of a medical condition such as hypothyroidism, pancreatitis, long-term use of certain medications such as prednisone, estrogens, beta-blockers, glucagon, and stress.

Some researchers suggested that an unhealthy lifestyle, in fact, is the major cause of the onset of hyperglycemia.

According to the study of a total of 485 subjects of Bai Ku Yao and 501 subjects of Han Chinese ethnicity aged 40 years and older surveyed by a stratified cluster random sampling technique, the prevalence of hyperlipidemia was significantly lower among ethnic Bai Ku Yao than among ethnic Han individuals, which might mainly be attributed to the more favorable dietary patterns, lifestyle choices, and physical activity levels in the former ethnic group.

These results strongly suggested that an unhealthy diet high in saturated and trans fat, red meat and processed food, and low fruits and vegetables are associated with the onset and early onset of hyperglycemia.


With an aim to find a natural ingredient or whole food for the prevention of diabetes, a metabolic disorder, and the emerging pandemic of the 21st century, researchers investigated the anti-diabetes activity of piperine, the chief alkaloid present in Piper nigrum (black pepper). The study included albino mice induced diabetes by injection of alloxan.

The tested mice were randomly divided into 5 groups (n = 6). In acute study, drugs were administered orally as: control (2% gum acacia, 10 mL/kg), standard (metformin 150 mg/kg), P10 (piperine 10 mg/kg), P20 (piperine 20 mg/kg) and P40 (piperine 40 mg/kg) and drug intervention for subacute study consisted of once daily oral administration for 14 days of 2% gum acacia 10 mL/kg, metformin 250 mg/kg, and piperine 5, 10 and 20 mg/kg, respectively.


By examing the blood glucose levels before and at 1, 2, 3, and 4 h post-dosing, respectively, in the acute study and on days 7 and 14 in the subacute study, researchers showed that the acute study showed that at 2 h post-dosing piperine at the high dose of 40 mg/kg showed a significant rise in blood glucose level (p < 0.05) in comparison to a control group.

Contrastly, a significant blood glucose-lowering effect was seen with piperine at a dose of 20 mg/kg on day 14 (p < 0.05) in the subacute study.

These results clearly suggested that subacute administration of piperine has a statistically significant antihyperglycemic activity while acutely it raises blood glucose at high doses.


In other words, in order for the piperine to exert antihyperglycemic activity, the initial dose should be reduced and increased gradually during the course of treatment.

The G. Pulla Reddy College of Pharmacy in the evaluation of the association between Piperine and P. longum is a known inhibitor of various enzymes (CYP isozymes) responsible for the biotransformation of drugs, suggested that by inhibiting the metabolism of drugs, piperine improves the bioavailability of drugs.

Truly, pretreatment of Piperine (10 mg/kg) accompanied by the anti-hyperglycemic activity of nateglinide (CAS no: 105816-04-4) exerted significantly increased the concentration of the drug. In other words, nateglinide is more effective in inhibiting hyperglycemia compared to the drug when it is applied alone.

Dr. Sama V, the lead author, after taking into account co and confounders said, "The synergistic anti-hyperglycemic activity of nateglinide when administered with piperine can be attributed to increased plasma concentration of nateglinide" and " The results of this study demonstrate that piperine could be used as a potential bioenhancer along with nateglinide".

In diabetes-induced oxidative stress in 30-day streptozotocin-induced diabetic Sprague-Dawley rats, piperine treatment intraperitoneally at the dose of 10 mg/kg/day for 14 days also reversed the diabetic effects caused by oxidative stress by improving the levels of antioxidant enzymes and inhibiting the levels of free radicals.

Taken altogether, piperine, a bioactive compound found in black pepper may be used for the prevention and treatment of abnormally high blood glucose in patients with diabetes, with no side effects

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Reference
(1) Evaluation of the effect of piperine per se on blood glucose level in alloxan-induced diabetic mice by Atal S, Agrawal RP, Vyas S, Phadnis P, Rai N.(PubMed)
(2) Effect of piperine on antihyperglycemic activity and pharmacokinetic profile of nateglinide by Sama V, Nadipelli M, Yenumula P, Bommineni MR, Mullangi R.(PubMed)
(3) Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats by Rauscher FM, Sanders RA, Watkins JB 3rd.(PubMed)