By Kyle J. Norton
Unlike general breast cancer which processes either receptors for estrogen or progesterone and/or receptors with a protein called HER2, triple-negative breast cancer is a form of breast cancer that does not share the aforementioned characteristics.
In other words, triple-negative breast cancer does not have receptors of estrogen or progesterone or genetic preposition.
More importantly, triple-negative breast cancer was found to infect women under the age of 40 and women of African or Asian ancestry in the US, compared to breast cancer in the White.
Particularly, according to the epidemiological study, younger women and women of African ancestry are susceptible to a higher risk of basal-like triple-negative breast cancers.
Compared to the malignant nature, triple-negative and basal-like breast cancers are highly invasive and can grow and spread quickly to other tissues and organs through lymph and blood.
Also compared to other breast cancer, with decreased risk after 5 years, triple-negative breast cancers have a substantially higher recurrent rate within 5 years after treatment.
Triple-negative breast cancer shares symptoms similar to those of breast cancer and risk factor except in the form of the genetic preposition.
According to Dr. Shimelis H, the lead scientist in the joint study led by the Mayo Clinic, said, "Pathogenic variants in BRIP1, RAD51C, and TP53 were associated with moderate risk (odds ratio > 2) of TNBC. Similar trends were observed for the African American population. Pathogenic variants in these TNBC genes were detected in 12.0% (3.7% non-BRCA1/2) of all participants".
And, "Multigene hereditary cancer panel testing can identify women with an elevated risk of TNBC due to mutations in BARD1, BRCA1, BRCA2, PALB2, and RAD51D".
In other words, if you carry the mutated genes BARD1, BRCA1, BRCA2, PALB2, and RAD51D, you are at a higher risk of triple-negative breast cancer.
In seeking a potential compound for the treatment of breast cancer, researchers reexamined the promising anticancer effects of novel C-substituted diindolylmethane (DIM) derivatives DIM-10 and DIM-14 in aggressive triple-negative breast cancer (TNBC, MDA-MB-231) models.
In vitro studies, novel C-substituted diindolylmethane (DIM) derivatives DIM-10 and DIM-14 demonstrated strong anti-cancer effects.
NLC formulations. including DIM-10 and DIM-14 extended significant increase in oral bioavailability compared to poor permeability and poor oral bioavailability of DIM-10 and DIM-14 used alone in pharmacokinetic studies.
Furthermore, compared to DIM-10, DIM-10 used alone, the NLC formulation showed an increase in Cmax and AUC values by 4.73 and 11.19-folds.
Similar increased anti-aggressive triple-negative breast cancer (TNBC) efficacy was also found in the DIM-14 NLC formulations.
In dogs, the DIM-10 NLC formulations showed an increase of 2.65 and 2.94-fold in Cmax and AUC, against triple-negative breast cancer (TNBC) respectively.
Moreover, DIM-10 or DIM-14 NLC formulations demonstrated significant a reduction in tumor volumes in TNBC models and treated animals.
Dr. Godugu C, the lead scientist after taking into account co and confounders wrote, "NLC formulation of both DIM-10 and 14 is effective in TNBC models".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of triple-negative breast cancer, pending the confirmation of the larger sample size and multicenter human study.
Intake of 3,3'-diindolylmethane in the form of a supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Novel diindolylmethane derivatives based NLC formulations to improve the oral bioavailability and anticancer effects in triple-negative breast cancer by Godugu C1, Doddapaneni R2, Safe SH3, Singh M. (PubMed)
(2) Triple-Negative Breast Cancer Risk Genes Identified by Multigene Hereditary Cancer Panel Testing by Shimelis H1, LaDuca H2, Hu C1, Hart SN3, Na J3, Thomas A3, Akinhanmi M1, Moore RM3, Brauch H4,5,6, Cox A7, Eccles DM8, Ewart-Toland A9, Fasching PA10,11,12, Fostira F13, Garber J14, Godwin AK15, Konstantopoulou I13, Nevanlinna H16, Sharma P15, Yannoukakos D13, Yao S17, Feng BJ18, Tippin Davis B2, Lilyquist J3, Pesaran T2, Goldgar DE18, Polley EC3, Dolinsky JS2, Couch. (PubMed)
Friday, 12 May 2023
#BroccoliSprout Extracts #Sulforaphane Inhibits the Onset of #CognitiveDeficits, According to Studies
By Kyle J. Norton
Cognition is the process of the brain functioning associated with the attention of working memory, producing and comprehending language, learning, reasoning, problem-solving, and decision-making.
A cognitive deficit is a medical condition, that affects a person's thinking, communication, understanding,, or memory. The cognitive deficit can be acute or chronic.
Acute cognitive deficit is a short-term health problem caused by drug toxicity and withdrawal, electrolyte disturbance, lack of drugs, liver disease, infection, reduced sensor input, intracranial urinary retention/fecal impaction, or myocardial/metabolic/pulmonary. An acute cognitive deficit may be recovered if the cause is found.
Chronic cognitive deficit is a permanent medical condition caused by the gradual or permanent loss of neurons, leading to problems with language, ideomotor and constructive praxis, visual gnosis, spatial attention, learning abilities, and executive functions.
There is no single cause of the chronic cognitive deficit. An increase in age, genetic preposition, certain medical conditions, such as diabetes, high blood cholesterol, and pressure, being obese, and lack of exercise are some prevalent factors found in patients with chronic cognitive deficits.
Some researchers suggested that depending on the locations of the brain that were affected, patients may be at risk of Alzheimer's disease such as brain change caused by the abnormal clumps of beta-amyloid protein (plaques).
Small strokes or reduced blood flow through the brain can also cause a chronic cognitive deficit.
According to the observation of the patient's MRI, the patient's brain with cognitive impairment also showed shrinkage of the hippocampus, a brain region important for memory, enlargement of the brain's fluid-filled spaces (ventricles), and reduced use of glucose, the sugar that's the primary source of energy for cells.
Out of many risk factors associated with the onset of the condition, obesity is also one of the major risk factors of cognitive impairment in the Western world.
Dr. Jason C. D. Nguyen, the lead author on the neurological team wrote in the final report, "The incidence of obesity in middle age is increasing markedly, and in parallel, the prevalence of metabolic disorders including cardiovascular disease and type II diabetes is also rising. Numerous studies have demonstrated that both obesity and metabolic disorders are associated with poorer cognitive performance, cognitive decline, and dementia".
Brussels sprouts are a species of wild cabbage (Brassica oleracea), that belongs to the family of Brassicaceae and was cultivated since ancient Rome.
With an aim to find a potential compound for the treatment of cognitive impairment, researchers examined the effects of dietary intake of sulforaphane-rich broccoli sprout extracts against parameters associated with the risk of cognitive dysfunction in patients with schizophrenia.
According to the results of the experiment, sulforaphane (SFN) derived from broccoli showed a strong effect in the activation of the transcription factor Nrf2 regulated by Keap1, a cytoplasmic protein that plays a central role against the stimulation of oxidative stress.
Moreover, pretreatment with SFN attenuated cognitive deficit, the increase in 8-oxo-dG-positive cells, and the decrease in PV-positive cells in the medial prefrontal cortex and hippocampus found in patients with a neurodegenerative disease caused by oxidative stress induced by administration of phencyclidine (PCP).
In other words, PCP-induced cognitive deficits were inhibited by the subsequent subchronic administration of SFN.
Believe it or not, chronic dietary intake of glucoraphanin (a glucosinolate precursor of SFN) during juvenile and adolescence not only prevented the onset of PCP-induced cognitive deficit but also increased in 8-oxo-dG-positive cells and the decreased in PV-positive cells in the brain at adulthood.
The results strongly suggested the NRF2 gene and the KEAP1 gene had an epistatic effect on gene reaction on cognitive impairment (e.g., working memory and processing speed) in patients with schizophrenia.
Based on the findings, researchers said, "SFN may have prophylactic and therapeutic effects on cognitive impairment in schizophrenia. Therefore, the dietary intake of SFN-rich broccoli sprouts during juvenile and adolescence may prevent the onset of psychosis in adulthood".
Taken altogether, broccoli sprouts processed abundantly SFN may be considered a functional food for the promotion of cognitive deficit, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood by Shirai Y1, Fujita Y1, Hashimoto R2, Ohi K3, Yamamori H3, Yasuda Y3, Ishima T1, Suganuma H4, Ushida Y4, Takeda M3, Hashimoto K. (PubMed)
(2) Obesity and cognitive decline: role of inflammation and vascular changes by Jason C. D. Nguyen,1 A. Simon Killcross,2 and Trisha A. Jenkins. (PMC)
Cognition is the process of the brain functioning associated with the attention of working memory, producing and comprehending language, learning, reasoning, problem-solving, and decision-making.
A cognitive deficit is a medical condition, that affects a person's thinking, communication, understanding,, or memory. The cognitive deficit can be acute or chronic.
Acute cognitive deficit is a short-term health problem caused by drug toxicity and withdrawal, electrolyte disturbance, lack of drugs, liver disease, infection, reduced sensor input, intracranial urinary retention/fecal impaction, or myocardial/metabolic/pulmonary. An acute cognitive deficit may be recovered if the cause is found.
Chronic cognitive deficit is a permanent medical condition caused by the gradual or permanent loss of neurons, leading to problems with language, ideomotor and constructive praxis, visual gnosis, spatial attention, learning abilities, and executive functions.
There is no single cause of the chronic cognitive deficit. An increase in age, genetic preposition, certain medical conditions, such as diabetes, high blood cholesterol, and pressure, being obese, and lack of exercise are some prevalent factors found in patients with chronic cognitive deficits.
Some researchers suggested that depending on the locations of the brain that were affected, patients may be at risk of Alzheimer's disease such as brain change caused by the abnormal clumps of beta-amyloid protein (plaques).
Small strokes or reduced blood flow through the brain can also cause a chronic cognitive deficit.
According to the observation of the patient's MRI, the patient's brain with cognitive impairment also showed shrinkage of the hippocampus, a brain region important for memory, enlargement of the brain's fluid-filled spaces (ventricles), and reduced use of glucose, the sugar that's the primary source of energy for cells.
Out of many risk factors associated with the onset of the condition, obesity is also one of the major risk factors of cognitive impairment in the Western world.
Dr. Jason C. D. Nguyen, the lead author on the neurological team wrote in the final report, "The incidence of obesity in middle age is increasing markedly, and in parallel, the prevalence of metabolic disorders including cardiovascular disease and type II diabetes is also rising. Numerous studies have demonstrated that both obesity and metabolic disorders are associated with poorer cognitive performance, cognitive decline, and dementia".
Brussels sprouts are a species of wild cabbage (Brassica oleracea), that belongs to the family of Brassicaceae and was cultivated since ancient Rome.
With an aim to find a potential compound for the treatment of cognitive impairment, researchers examined the effects of dietary intake of sulforaphane-rich broccoli sprout extracts against parameters associated with the risk of cognitive dysfunction in patients with schizophrenia.
According to the results of the experiment, sulforaphane (SFN) derived from broccoli showed a strong effect in the activation of the transcription factor Nrf2 regulated by Keap1, a cytoplasmic protein that plays a central role against the stimulation of oxidative stress.
Moreover, pretreatment with SFN attenuated cognitive deficit, the increase in 8-oxo-dG-positive cells, and the decrease in PV-positive cells in the medial prefrontal cortex and hippocampus found in patients with a neurodegenerative disease caused by oxidative stress induced by administration of phencyclidine (PCP).
In other words, PCP-induced cognitive deficits were inhibited by the subsequent subchronic administration of SFN.
Believe it or not, chronic dietary intake of glucoraphanin (a glucosinolate precursor of SFN) during juvenile and adolescence not only prevented the onset of PCP-induced cognitive deficit but also increased in 8-oxo-dG-positive cells and the decreased in PV-positive cells in the brain at adulthood.
The results strongly suggested the NRF2 gene and the KEAP1 gene had an epistatic effect on gene reaction on cognitive impairment (e.g., working memory and processing speed) in patients with schizophrenia.
Based on the findings, researchers said, "SFN may have prophylactic and therapeutic effects on cognitive impairment in schizophrenia. Therefore, the dietary intake of SFN-rich broccoli sprouts during juvenile and adolescence may prevent the onset of psychosis in adulthood".
Taken altogether, broccoli sprouts processed abundantly SFN may be considered a functional food for the promotion of cognitive deficit, pending the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood by Shirai Y1, Fujita Y1, Hashimoto R2, Ohi K3, Yamamori H3, Yasuda Y3, Ishima T1, Suganuma H4, Ushida Y4, Takeda M3, Hashimoto K. (PubMed)
(2) Obesity and cognitive decline: role of inflammation and vascular changes by Jason C. D. Nguyen,1 A. Simon Killcross,2 and Trisha A. Jenkins. (PMC)
#Anise, the Herbal Medicine That Processes Anti-#Depression Properties, Scientists Show
By Kyle J. Norton
Anise may have a potential and substantial effect in reduced risk and treatment of depression, some scientists suggested.
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners, and stomachic, anti-septic, anti-spasmodic,...
Chemical constituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.
Depression is a condition of a mood disorder. affecting the patient's feelings, thinking, and handle daily activities.
According to the statistic of The National Institute of Mental Health, approximately, 16 million adults had at least one major depressive episode in 2012 in the United States, 6.9 percent of the population.
In the evaluation of the herbal Anise aqueous and ethanol extracts antidepressant-like effects in mice with several different doses of 50, 100, and 200 mg/kg in compared to the standard medicine Fluoxetine at the dose of 30mg/kg and imipramine at the dose of 20mg/kg, researchers at the joint study lead by the Azad University showed that except for the dose at 50mg/kg of aqueous extract, application of other doses demonstrated a linearly significant improvement of mobility times.
Further analysis also found that all doses from Anise extract increased the swimming time dose-dependently, without any significant change in climbing time in tested mice similar to those of Fluoxetine and compared to aqueous extract.
Moreover, Fluoxetine and imipramine expressed a strong decreased immobility time in both tests in contrast to imipramine's increased climbing time without any significant change in swimming time.
The result suggested that both extracts in a dose higher than 50mg/kg display antidepressant-like activity similar to that of fluoxetine through improved mobility of depressed mice as inactivity is considered one of the major symptoms in patients with depression.
As the depression progressed, patients demonstrated behavior in making efforts to escape from society, eventually will exhibit immobility with the reflection of psychological despair.
Dr. Shahamat Z the lead author said, " P. anisum possesses an antidepressant-like activity similar to that of fluoxetine, which has a potential clinical value for application in the management of depression".
Additionally, in the testing essential (volatile) oil and essential oil of Piper laetispicum antidepressant activity in compared to Fluoxetine as standard antidepressant drug and other natural remedies including Leaves-Bay, Curry, Coriander and Mint; Fruits-Star anise, Pepper, Cardamom, Caraway and Fennel; Seeds of Fenugreek, Mustard, Nutmeg and Black Cumin; and Underground stem-Onion, Garlic, Ginger and Turmeric; Miscellaneous-Clove, Cinnamon, Capsicum, Tamarind and Asafoetida, researchers found that all participated essential oil, especially anise produced a significant reduction in immobility along with an increase in climbing behavior similar to those of fluoxetine.
The application of essential oil caused a dose-dependent reduction( probably in a dose less than 50 mg/kg) in immobility which is contracted to the above study and an increase in climbing at all studied doses in comparison to the control group.
However, the test may not take into effect in real-life patients who need to be treated for at least several weeks before they experience any relief from the expression of symptoms.
Furthermore, in the examination of the efficacy of anise oil, in removing the symptoms of mild to moderate depression in patients with irritable bowel syndrome a total of 120 randomly assigned into 3 equal groups received anise oil, Colpermin, and placebo, at the end of the study, scientists showed that application of anise group exerted a continuous improvement of the syndrome in compared to the other 2 groups with some unknown mechanisms.
Some researchers postulated that essential oil smell may have a profound effect on the brain in triggering an emotional reaction in stimulating the limbic system in regulated autonomic and endocrine function, particularly, in response to emotional stimuli in an expression of motivation and reinforcing behaviors.
Additionally, the application of essential oil scent also has a direct influence in calming the central nervous system in ameliorating the overproduction of certain hormones in reacting to unfavorably emotional behaviors.
Taken together, Anise essential oil may be used as a secondary therapy to standard medicine in the treatment of depression.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Evaluation of antidepressant-like effects of aqueous and ethanolic extracts of Pimpinella anisum fruit in mice by Shahamat Z1, Abbasi-Maleki S2, Mohammadi Motamed S3.(PubMed)
(2) Effectiveness of Anise Oil for Treatment of Mild to Moderate Depression in Patients With Irritable Bowel Syndrome. A Randomized Active and Placebo-Controlled Clinical Trial by Maryam Mosaffa-Jahromi, PharmD, Ph.D., Ali-Mohammad Tamaddon, PharmD, Ph.D., Suleiman Afsharypuor, PharmD, Ph.D., Alireza Salehi, MD, MPH, Ph.D., Seyed Hassan Seradj, PharmD, Ph.D., Mehdi Pasalar MD, MPH, Ph.D., Peyman Jafari, Ph.D., Kamran Bagheri Lankarani, MD (Journal of Evidence-Based Integrative Medicine)
(3) Essential oil isolation from culinary drugs and screening for antidepressant potential Mohib Abdul Jalil Khan , Imtiyaz Ansari, Amjad Ali Mohammad Iqbal Oriental College of Pharmacy, Navi Mumbai, Maharashtra- 400705, India.(INTERNATIONAL JOURNAL OF ADVANCES INPHARMACY MEDICINE AND BIOALLIED SCIENCES)
(4) The Forced Swim Test as a Model of Depressive-like Behavior by Roni Yankelevitch-Yahav, 1 , 2 Motty Franko, 2 Avrham Huly, 2 and Ravid Doron(PMC)
Anise may have a potential and substantial effect in reduced risk and treatment of depression, some scientists suggested.
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners, and stomachic, anti-septic, anti-spasmodic,...
Chemical constituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.
Depression is a condition of a mood disorder. affecting the patient's feelings, thinking, and handle daily activities.
According to the statistic of The National Institute of Mental Health, approximately, 16 million adults had at least one major depressive episode in 2012 in the United States, 6.9 percent of the population.
In the evaluation of the herbal Anise aqueous and ethanol extracts antidepressant-like effects in mice with several different doses of 50, 100, and 200 mg/kg in compared to the standard medicine Fluoxetine at the dose of 30mg/kg and imipramine at the dose of 20mg/kg, researchers at the joint study lead by the Azad University showed that except for the dose at 50mg/kg of aqueous extract, application of other doses demonstrated a linearly significant improvement of mobility times.
Further analysis also found that all doses from Anise extract increased the swimming time dose-dependently, without any significant change in climbing time in tested mice similar to those of Fluoxetine and compared to aqueous extract.
Moreover, Fluoxetine and imipramine expressed a strong decreased immobility time in both tests in contrast to imipramine's increased climbing time without any significant change in swimming time.
The result suggested that both extracts in a dose higher than 50mg/kg display antidepressant-like activity similar to that of fluoxetine through improved mobility of depressed mice as inactivity is considered one of the major symptoms in patients with depression.
As the depression progressed, patients demonstrated behavior in making efforts to escape from society, eventually will exhibit immobility with the reflection of psychological despair.
Dr. Shahamat Z the lead author said, " P. anisum possesses an antidepressant-like activity similar to that of fluoxetine, which has a potential clinical value for application in the management of depression".
Additionally, in the testing essential (volatile) oil and essential oil of Piper laetispicum antidepressant activity in compared to Fluoxetine as standard antidepressant drug and other natural remedies including Leaves-Bay, Curry, Coriander and Mint; Fruits-Star anise, Pepper, Cardamom, Caraway and Fennel; Seeds of Fenugreek, Mustard, Nutmeg and Black Cumin; and Underground stem-Onion, Garlic, Ginger and Turmeric; Miscellaneous-Clove, Cinnamon, Capsicum, Tamarind and Asafoetida, researchers found that all participated essential oil, especially anise produced a significant reduction in immobility along with an increase in climbing behavior similar to those of fluoxetine.
The application of essential oil caused a dose-dependent reduction( probably in a dose less than 50 mg/kg) in immobility which is contracted to the above study and an increase in climbing at all studied doses in comparison to the control group.
However, the test may not take into effect in real-life patients who need to be treated for at least several weeks before they experience any relief from the expression of symptoms.
Furthermore, in the examination of the efficacy of anise oil, in removing the symptoms of mild to moderate depression in patients with irritable bowel syndrome a total of 120 randomly assigned into 3 equal groups received anise oil, Colpermin, and placebo, at the end of the study, scientists showed that application of anise group exerted a continuous improvement of the syndrome in compared to the other 2 groups with some unknown mechanisms.
Some researchers postulated that essential oil smell may have a profound effect on the brain in triggering an emotional reaction in stimulating the limbic system in regulated autonomic and endocrine function, particularly, in response to emotional stimuli in an expression of motivation and reinforcing behaviors.
Additionally, the application of essential oil scent also has a direct influence in calming the central nervous system in ameliorating the overproduction of certain hormones in reacting to unfavorably emotional behaviors.
Taken together, Anise essential oil may be used as a secondary therapy to standard medicine in the treatment of depression.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
Sources
(1) Evaluation of antidepressant-like effects of aqueous and ethanolic extracts of Pimpinella anisum fruit in mice by Shahamat Z1, Abbasi-Maleki S2, Mohammadi Motamed S3.(PubMed)
(2) Effectiveness of Anise Oil for Treatment of Mild to Moderate Depression in Patients With Irritable Bowel Syndrome. A Randomized Active and Placebo-Controlled Clinical Trial by Maryam Mosaffa-Jahromi, PharmD, Ph.D., Ali-Mohammad Tamaddon, PharmD, Ph.D., Suleiman Afsharypuor, PharmD, Ph.D., Alireza Salehi, MD, MPH, Ph.D., Seyed Hassan Seradj, PharmD, Ph.D., Mehdi Pasalar MD, MPH, Ph.D., Peyman Jafari, Ph.D., Kamran Bagheri Lankarani, MD (Journal of Evidence-Based Integrative Medicine)
(3) Essential oil isolation from culinary drugs and screening for antidepressant potential Mohib Abdul Jalil Khan , Imtiyaz Ansari, Amjad Ali Mohammad Iqbal Oriental College of Pharmacy, Navi Mumbai, Maharashtra- 400705, India.(INTERNATIONAL JOURNAL OF ADVANCES INPHARMACY MEDICINE AND BIOALLIED SCIENCES)
(4) The Forced Swim Test as a Model of Depressive-like Behavior by Roni Yankelevitch-Yahav, 1 , 2 Motty Franko, 2 Avrham Huly, 2 and Ravid Doron(PMC)
#Herbal #Butterbur Inhibits the Onset of #Migraine, Scientists Show
By Kyle J. Norton
Herbal butterbur may be considered a functional herb in the protection of neurons against changes in the brain and its surrounding blood vessels in the initiated onset of migraine, some scientists suggested.
Migraine headache is one most common headaches defined as the condition of a chronic neurological disorder of moderate to severe headaches, and nausea that usually develop gradually over 5–20 minutes and last for less than 60 minutes.
According to the statistic, the syndrome affects over 15% of the population in the US. If you are a woman your risk of migraine headaches is 2 times higher in compared to men.
Sadly, 1 in 7 people in the world population will develop migraine headaches at some point in their lifetime, And, chronic migraine affects about 2% of the world population.
Some patients during migraine attacks also suffer symptoms of visual disturbances, nausea, vomiting, dizziness, extreme sensitivity to sound, light, touch, and smell, and tingling or numbness in the extremities or face.
Believe it or not, 10% of school-age children also suffer from undiagnosed migraine headaches.
Conventional medicine in reduced symptoms of pain during an attack such as Sumatriptan, Rizatriptan,..and Eletriptan may be effective but they may induce certain side effects, including gastrointestinal discomfort, dizziness, drowsiness,... and muscle weakness.
Please make sure that you discuss these side effects with your doctor before taking them.
Butterbur, found in wet, marshy, damp land, including wetlands, riversides, forests, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to the Northern Hemisphere.
The herb has been used in herbal medicine used as a pain reliever in the digestive system, including the stomach, bile ducts, duodenum, etc.
Although the herb is used as a nutritional supplement in the US, scientific studies suggested that it may be used for the prevention of allergic rhinitis and the treatment of migraine.
In a three-arm, parallel-group, randomized trial comparing Petasites extract 75 mg bid, Petasites extract 50 mg bid, or placebo bid in 245 patients with migraine, satisfied the International Headache Society criteria, researchers found that by calculating the migraine attack frequency.
ency per month as a percentage change from baseline over a 4-month treatment period
* Migraine attack frequency was reduced by 48% for Petasites extract 75 mg bid (p = 0.0012 vs placebo), 36% for Petasites extract 50 mg bid (p = 0.127 vs placebo), compared to 26% of the placebo group.
* The proportion of patients with a > or =50% reduction in attack frequency after 4 months was 68% for patients in the Petasites extract 75-mg arm and 49% for the placebo arm (p < 0.05).
* In comparison to the baseline, patients, intake of Petasites 75 mg also expressed a significant effect in reduced migraine at 1, 2, and 3 months.
* Mild adverse effects such as gastrointestinal events, predominantly burping. were also reported.
These results suggest that butterbur Petasites extract 75 mg bid is more effective than placebo and is well tolerated as a preventive therapy for migraine.
Furthermore, in the review to confirm the strength of evidence of effectiveness for Petasites hybridus in treating prophylaxis of migraine by searching several databases and other sources to identify randomized-controlled trials, the Headache Center Hirslanden in Zürich, Switzerland found 2 trials totaling 293 patients (60 and 233 patients).
According to the selected trials, orally administrated butterbur extract at a higher dose (150 mg) expressed a greater decreased frequency of migraine attacks and a greater number of responders (improvement>50%) after treatment over 3-4 months compared to the extract at a lower dose (100 mg) and placebo.
Additional differentiation also found some evidence that higher than the recommended dose may be more effective in treating prophylaxis of migraine.
More profoundly, in the study of 60 patients who received either the special Petasites hybridus extract Petadolex or placebo at a dosage of two capsules (each capsule contains 25 mg) twice daily over 12 weeks, researchers found that
* Oral injection of the capsules Petadolex reduces the frequency of migraine attacks decreased by a maximum of 60 percent compared to the baseline.
* No adverse events were reported. Petasites were exceptionally well tolerated.
Taking all together, herbal butterbur extract may be considered a therapeutic treatment in acute and chronic migraine headaches, however, the exact dose should only be prescribed by an herbalist.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye FloatersContrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
References
(1) Petasites hybridus root (butterbur) is an effective preventive treatment for migraine by Lipton RB, Göbel H, Einhäupl KM, Wilks K, Mauskop A.(PubMed)
(2) An extract of Petasites hybridus is effective in the prophylaxis of migraine by Grossman W, Schmidramsl H.(PubMed)
(3) Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: a systematic review by Agosti R, Duke RK, Chrubasik JE, Chrubasik S.(PubMed)
Herbal butterbur may be considered a functional herb in the protection of neurons against changes in the brain and its surrounding blood vessels in the initiated onset of migraine, some scientists suggested.
Migraine headache is one most common headaches defined as the condition of a chronic neurological disorder of moderate to severe headaches, and nausea that usually develop gradually over 5–20 minutes and last for less than 60 minutes.
According to the statistic, the syndrome affects over 15% of the population in the US. If you are a woman your risk of migraine headaches is 2 times higher in compared to men.
Sadly, 1 in 7 people in the world population will develop migraine headaches at some point in their lifetime, And, chronic migraine affects about 2% of the world population.
Some patients during migraine attacks also suffer symptoms of visual disturbances, nausea, vomiting, dizziness, extreme sensitivity to sound, light, touch, and smell, and tingling or numbness in the extremities or face.
Believe it or not, 10% of school-age children also suffer from undiagnosed migraine headaches.
Conventional medicine in reduced symptoms of pain during an attack such as Sumatriptan, Rizatriptan,..and Eletriptan may be effective but they may induce certain side effects, including gastrointestinal discomfort, dizziness, drowsiness,... and muscle weakness.
Please make sure that you discuss these side effects with your doctor before taking them.
Butterbur, found in wet, marshy, damp land, including wetlands, riversides, forests, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to the Northern Hemisphere.
The herb has been used in herbal medicine used as a pain reliever in the digestive system, including the stomach, bile ducts, duodenum, etc.
Although the herb is used as a nutritional supplement in the US, scientific studies suggested that it may be used for the prevention of allergic rhinitis and the treatment of migraine.
In a three-arm, parallel-group, randomized trial comparing Petasites extract 75 mg bid, Petasites extract 50 mg bid, or placebo bid in 245 patients with migraine, satisfied the International Headache Society criteria, researchers found that by calculating the migraine attack frequency.
ency per month as a percentage change from baseline over a 4-month treatment period
* Migraine attack frequency was reduced by 48% for Petasites extract 75 mg bid (p = 0.0012 vs placebo), 36% for Petasites extract 50 mg bid (p = 0.127 vs placebo), compared to 26% of the placebo group.
* The proportion of patients with a > or =50% reduction in attack frequency after 4 months was 68% for patients in the Petasites extract 75-mg arm and 49% for the placebo arm (p < 0.05).
* In comparison to the baseline, patients, intake of Petasites 75 mg also expressed a significant effect in reduced migraine at 1, 2, and 3 months.
* Mild adverse effects such as gastrointestinal events, predominantly burping. were also reported.
These results suggest that butterbur Petasites extract 75 mg bid is more effective than placebo and is well tolerated as a preventive therapy for migraine.
Furthermore, in the review to confirm the strength of evidence of effectiveness for Petasites hybridus in treating prophylaxis of migraine by searching several databases and other sources to identify randomized-controlled trials, the Headache Center Hirslanden in Zürich, Switzerland found 2 trials totaling 293 patients (60 and 233 patients).
According to the selected trials, orally administrated butterbur extract at a higher dose (150 mg) expressed a greater decreased frequency of migraine attacks and a greater number of responders (improvement>50%) after treatment over 3-4 months compared to the extract at a lower dose (100 mg) and placebo.
Additional differentiation also found some evidence that higher than the recommended dose may be more effective in treating prophylaxis of migraine.
More profoundly, in the study of 60 patients who received either the special Petasites hybridus extract Petadolex or placebo at a dosage of two capsules (each capsule contains 25 mg) twice daily over 12 weeks, researchers found that
* Oral injection of the capsules Petadolex reduces the frequency of migraine attacks decreased by a maximum of 60 percent compared to the baseline.
* No adverse events were reported. Petasites were exceptionally well tolerated.
Taking all together, herbal butterbur extract may be considered a therapeutic treatment in acute and chronic migraine headaches, however, the exact dose should only be prescribed by an herbalist.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye FloatersContrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bio Science, ISSN 0975-6299.
References
(1) Petasites hybridus root (butterbur) is an effective preventive treatment for migraine by Lipton RB, Göbel H, Einhäupl KM, Wilks K, Mauskop A.(PubMed)
(2) An extract of Petasites hybridus is effective in the prophylaxis of migraine by Grossman W, Schmidramsl H.(PubMed)
(3) Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: a systematic review by Agosti R, Duke RK, Chrubasik JE, Chrubasik S.(PubMed)
#Healthyfood #Avocado in the Promotes of Skin Health, Researchers Find
By Kyle J. Norton
Researchers may have found a whole fruit for the promotion of skin health with no side effects, according to studies.
Skin, a large organ of the body protects our tissue and organs against the invasion of pathogens and fluid loss.
There are many causes of skin damage. Sun exposure is the most common cause of skin damage. Other causes of skin damage include smoking cigarettes, drinking too much alcohol, extreme temperatures, and exposure to toxic chemicals and pollutants in the air outside.
Some researchers suggested that free radicals bombard our bodies daily and are also associated with skin damage in the modern world.
Free radicals are unstable molecules with the unpaired electron on the outer ring. In order for them to become balanced, free radical either donates or intercept an electron from another stable molecule, leading to a chain reaction that can not be stopped until the outer ring election is paired or inhibited by an antioxidant.
In fact, free radical formation occurs continuously in the cells as a consequence of both enzymatic and nonenzymatic reactions, they can be generated by our bodies such as the process of metabolism and exogenous sources such as pollution, alcohol, and tobacco smoke.
Free radicals can affect our skin in different ways, including the alternation of the DNA, damage of lipid membranes, and collagen structures, and inducing photoaging and cancer.
Dr. Borut Poljšak, in the study "Free Radicals and Extrinsic Skin Aging," wrote, "Extrinsic skin damage develops due to several factors: ionizing radiation, severe physical and psychological stress, alcohol intake, poor nutrition, overeating, environmental pollution, and exposure to UV radiation (UVR)". and
"The only protection of our skin is in its endogenous protection (melanin and enzymatic antioxidants) and antioxidants we consume from the food (vitamin A, C, E, etc.)".
These results suggested that although free radicals can induce the early onset of skin damage and aging, providing our body with enough antioxidants from food sources is the best way to counter the process.
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world. It is a green-skinned, pear-shaped fruit that ripens after harvesting and is native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
In finding a natural ingredient or essential oil that has a potential effect on skin health without inducing any side effects, researchers explored the effects of various avocado oils on collagen metabolism.
In skin rats fed diets containing 10% (w/w) of the tested oils, researchers found the akin protective effects were totally dependent on the types of avocado oil.
Rats fed the unrefined avocado oil extracted with hexane from the intact fruit, including unsaponifiable or avocado seed oil, showed a significant increase in soluble collagen content in the skin, though total collagen content was not affected.
The increased soluble collagen content was attributed to the inhibition of lysyl oxidase activity whose increment is associated with the oxidative stress induced by chronic exposure to skin harmful substances.
The active factor which protects skin health was found to be present in the unrefined avocado oil and probably originated from the avocado seed, observed by the collagen metabolism which is affected only by fractions containing lipids fraction from the seed.
In order to illustrate the effects of avocado oil on skin health, researchers evaluated the wound-healing activity of a semisolid formulation of avocado oil, SSFAO 50%, or avocado oil in natural, on incisional, and excisional cutaneous wound models in Wistar rats.
On the 14 days of application on the wound, 50% SSFAO or avocado oil demonstrate a significant increase in percentage wound contraction and reepithelialization, compared to the petroleum jelly control.
The treatment group also displayed an increase in anti-inflammatory activity, density of collagen, and tensile strength, compared to control groups.
This efficacy of the 50% SSFAO or avocado oil was attributed to the contents of the bioactive compounds, oleic fatty acid (47.20%), followed by palmitic (23.66%), linoleic (13.46%) docosadienoic (8.88%), palmitoleic (3.58%), linolenic (1.60%), eicosenoic (1.29%), and myristic acids (0.33%).
Dr. de Oliveira AP, the lead scientist wrote in the final report, "When used in natural or in pharmaceutical formulations for topical use, avocado oil can promote increased collagen synthesis and decreased numbers of inflammatory cells during the wound-healing process".
In skin exposure to ultraviolet (UV) radiation, unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, reduced significantly UV-induced cellular damage, through increasing cell viability, decreased the secretion of IL-6, a pro-inflammatory cytokine, and PGE(2) in mediated the inflammation process.
Taken altogether, avocado processed abundantly bioactive compounds may be considered a functional food for the promotion of skin health without inducing any side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The effect of various avocado oils on skin collagen metabolism by Werman MJ1, Mokady S, Nimni ME, Neeman I.(PubMed)
(2) Effect of semisolid formulation of persea americana mill (avocado) oil on wound healing in rats by de Oliveira AP1, Franco Ede S, Rodrigues Barreto R, Cordeiro DP, de Melo RG, de Aquino CM, E Silva AA, de Medeiros PL, da Silva TG, Góes AJ, Maia MB.(PubMed)
(3) Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells by Rosenblat G1, Meretski S, Segal J, Tarshis M, Schroeder A, Zanin-Zhorov A, Lion G, Ingber A, Hochberg M.(PubMed)
(4) Free Radicals and Extrinsic Skin Aging by Borut Poljšak 1 and Raja Dahmane. (PMC)
Researchers may have found a whole fruit for the promotion of skin health with no side effects, according to studies.
Skin, a large organ of the body protects our tissue and organs against the invasion of pathogens and fluid loss.
There are many causes of skin damage. Sun exposure is the most common cause of skin damage. Other causes of skin damage include smoking cigarettes, drinking too much alcohol, extreme temperatures, and exposure to toxic chemicals and pollutants in the air outside.
Some researchers suggested that free radicals bombard our bodies daily and are also associated with skin damage in the modern world.
Free radicals are unstable molecules with the unpaired electron on the outer ring. In order for them to become balanced, free radical either donates or intercept an electron from another stable molecule, leading to a chain reaction that can not be stopped until the outer ring election is paired or inhibited by an antioxidant.
In fact, free radical formation occurs continuously in the cells as a consequence of both enzymatic and nonenzymatic reactions, they can be generated by our bodies such as the process of metabolism and exogenous sources such as pollution, alcohol, and tobacco smoke.
Free radicals can affect our skin in different ways, including the alternation of the DNA, damage of lipid membranes, and collagen structures, and inducing photoaging and cancer.
Dr. Borut Poljšak, in the study "Free Radicals and Extrinsic Skin Aging," wrote, "Extrinsic skin damage develops due to several factors: ionizing radiation, severe physical and psychological stress, alcohol intake, poor nutrition, overeating, environmental pollution, and exposure to UV radiation (UVR)". and
"The only protection of our skin is in its endogenous protection (melanin and enzymatic antioxidants) and antioxidants we consume from the food (vitamin A, C, E, etc.)".
These results suggested that although free radicals can induce the early onset of skin damage and aging, providing our body with enough antioxidants from food sources is the best way to counter the process.
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world. It is a green-skinned, pear-shaped fruit that ripens after harvesting and is native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
In finding a natural ingredient or essential oil that has a potential effect on skin health without inducing any side effects, researchers explored the effects of various avocado oils on collagen metabolism.
In skin rats fed diets containing 10% (w/w) of the tested oils, researchers found the akin protective effects were totally dependent on the types of avocado oil.
Rats fed the unrefined avocado oil extracted with hexane from the intact fruit, including unsaponifiable or avocado seed oil, showed a significant increase in soluble collagen content in the skin, though total collagen content was not affected.
The increased soluble collagen content was attributed to the inhibition of lysyl oxidase activity whose increment is associated with the oxidative stress induced by chronic exposure to skin harmful substances.
The active factor which protects skin health was found to be present in the unrefined avocado oil and probably originated from the avocado seed, observed by the collagen metabolism which is affected only by fractions containing lipids fraction from the seed.
In order to illustrate the effects of avocado oil on skin health, researchers evaluated the wound-healing activity of a semisolid formulation of avocado oil, SSFAO 50%, or avocado oil in natural, on incisional, and excisional cutaneous wound models in Wistar rats.
On the 14 days of application on the wound, 50% SSFAO or avocado oil demonstrate a significant increase in percentage wound contraction and reepithelialization, compared to the petroleum jelly control.
The treatment group also displayed an increase in anti-inflammatory activity, density of collagen, and tensile strength, compared to control groups.
This efficacy of the 50% SSFAO or avocado oil was attributed to the contents of the bioactive compounds, oleic fatty acid (47.20%), followed by palmitic (23.66%), linoleic (13.46%) docosadienoic (8.88%), palmitoleic (3.58%), linolenic (1.60%), eicosenoic (1.29%), and myristic acids (0.33%).
Dr. de Oliveira AP, the lead scientist wrote in the final report, "When used in natural or in pharmaceutical formulations for topical use, avocado oil can promote increased collagen synthesis and decreased numbers of inflammatory cells during the wound-healing process".
In skin exposure to ultraviolet (UV) radiation, unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, reduced significantly UV-induced cellular damage, through increasing cell viability, decreased the secretion of IL-6, a pro-inflammatory cytokine, and PGE(2) in mediated the inflammation process.
Taken altogether, avocado processed abundantly bioactive compounds may be considered a functional food for the promotion of skin health without inducing any side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals' Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The effect of various avocado oils on skin collagen metabolism by Werman MJ1, Mokady S, Nimni ME, Neeman I.(PubMed)
(2) Effect of semisolid formulation of persea americana mill (avocado) oil on wound healing in rats by de Oliveira AP1, Franco Ede S, Rodrigues Barreto R, Cordeiro DP, de Melo RG, de Aquino CM, E Silva AA, de Medeiros PL, da Silva TG, Góes AJ, Maia MB.(PubMed)
(3) Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells by Rosenblat G1, Meretski S, Segal J, Tarshis M, Schroeder A, Zanin-Zhorov A, Lion G, Ingber A, Hochberg M.(PubMed)
(4) Free Radicals and Extrinsic Skin Aging by Borut Poljšak 1 and Raja Dahmane. (PMC)
#Honey Inhibits the Risk of #BreastCancer, Studies Suggest
By Kyle J. Norton
Scientists may have found a sweet whole food which processes a strong effect in the prevention and treatment of breast cancer, according to some studies.
Breast cancer is a medical condition characterized by cell growth irregularly and disorderly in the breast tissue.
Most cases of breast cancer start in the cell on the surface of the inner lining of the breast tissue before spreading into deeper layers of the breast.
In the early stage, most patients with breast cancer may experience lumps on the breast or surrounding the breast.
However, breast skin irritation or dimpling, nipple pain, nipple retraction (turning inward), redness, and scaliness that cannot be healed within 3 weeks are also the signs and symptoms of breast cancer.
At the later stage, after colonizing most parts of the breast, the breast cancer cells may travel a distance far the way to infect other healthy cells and tissue.
In Canada, according to the statistic, 11% of women will develop breast cancer by the time they reach 90 years of age.
Just about 20% of breast cancers in Canada are diagnosed in women under 50, while almost 30% are diagnosed in women over 70 years of age.
These results suggested that the most common risk factor to fuel the onset of breast cancer is the increase in age.
The concern of the increasing number of studies indicates that the strength and even direction the association between breast cancer and established risk factors differ according to the woman's age when she develops the disease, Dr. Tryggvadóttir L, the lead scientist. according to the result of the study of a cohort of 80.219 women attending population-based cervical and breast cancer screening in Iceland, 1120 cases were identified, aged 26-90 years at diagnosis, and 10,537 controls, individually matched to the cases on birth year and age when attending wrote at the final report, "age at diagnosis should be taken into account when studying the effects of breast cancer risk factors".
Sadly to let you know that 60% of women who carry the genetic mutation of gene BRCA1 and 2 have breast cancer developed before the age of 70.
Other risk factors associated with the onset of breast cancer are reproductive history having a dense breast, personal and family history, previous intake of the drug diethylstilbestrol (DES), previous radiotherapy.
Regardless of all risk factors, women's breast self-examinations are still the most important methods to have breast cancer diagnosed early and increase the years of survival.
According to worldwide statistics, the 5 survival rate of the early stage of breast cancer is 100%.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one healthy sweet food for replacing the use of white sugar and artificial sweetener many people.
In finding natural compounds in cancer therapy, researchers at the United Arab Emirates University conducted an experiment to test the underlying mechanism and molecular targets of manuka honey (MH) on proliferation, invasiveness, and angiogenic potential were investigated using two human breast cancer cell lines, the triple-negative MDA-MB-231 cells and estrogen receptor-positive MCF-7 cells, and the non-neoplastic breast epithelial MCF-10A cell line.
Infection of MH at concentrations of 0.3-1.25% (w/v) induced a dose-dependent inhibition of the proliferation of MDA-MB-231 and MCF-7, but not MCF-10A, cells.
At higher concentrations (>2.5%), MH was found to be generally deleterious to the growth of all three cell lines.
MH induced apoptosis of MDA-MB-231 cells through activation of proteins associated with the cell death programming and cancer cells apoptosis correlated with a loss of proteins associated with cancer cell proliferation.
Furthermore, low concentrations of MH (0.03-1.25% w/v) induced a rapid reduction in tyrosine-phosphorylated STAT3 (pY-STAT3) involved in cell growth and division in MDA-MB-231 and MCF-7 cells.
The maximum inhibition of pY-STAT3 was observed at 1 h with a loss of >80% and coincided with decreased interleukin-6 (IL-6) production.
These results suggested manuka honey (MH) inhibits breast cancer cell lines through many different mechanisms
A total of 50 nulliparous female Sprague-Dawley rats were grouped as follows: Group 0 (healthy normal rats control), Group 1 (negative control; untreated rats), Groups 2, 3, and 4 received daily doses of 0.2, 1.0, and 2.0 g/kg body weight of TH, respectively. The rats in groups 1, 2, 3, 4 were induced with 80 mg/kg of 1-methyl-1-nitrosourea (MNU) to examine the effects of Tualang honey (TH) against breast cancer.
The TH-treated rats showed a reduction of tumor progression (mean 75.3 days versus 51.5 days) compared to control.
The incidence (mean 76.6% versus 100%); the multiplicity (mean 2.5 versus 4 tumor masses per rat); the size of tumor mass (mean 0.41 cm versus 1.47 cm [p < 0.05]) and the weight of the tumor mass (mean 1.22 g versus 3.23 g; [p < 0.05]) also lower in the TH treated rats compared to control.
The grade of breast cancer is lower (I and II) compared to control (Grade III),
The efficacy of TH treatment in reducing the expression of breast cancer was attributed to the lower anti-apoptotic proteins (E2, ESR1, and Bcl-xL) expression and a higher pro-apoptotic proteins (Apaf-1 and Caspase-9) expression at serum and on the cancer tissue level.
The breast cancer size breast in the TH-treated groups was smaller mean tumor size (≤ 2 cm3) compared to Controls (≤ 8 cm3). The number of cancers developing in TH-treated groups was also significantly lower.
More importantly, an increasing trend of the apoptotic index (AI) was found in TH-treated groups with an increasing dosage of Tualang Honey compared to control.
Taken altogether, adding a portion of honey into a women's diet may have a potential effect in reducing the risk of breast cancer.
And honey may be considered an adjunct therapy combined with the primary medicine for the treatment of breast cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The IL-6/STAT3 Signaling Pathway Is an Early Target of Manuka Honey-Induced Suppression of Human Breast Cancer Cells by Aryappalli P1, Al-Qubaisi SS1, Attoub S2, George JA1,3, Arafat K2, Ramadi KB1, Mohamed YA1, Al-Dhaheri MM1, Al-Sbiei A1, Fernandez-Cabezudo MJ3, Al-Ramadi BK. (PubMed)
(2) The anti-cancer effects of Tualang honey in modulating breast carcinogenesis: an experimental animal study by Ahmed S1,2, Othman NH. (PubMed)
(3) Inhibitory effects of Tualang Honey on experimental breast cancer in rats: a preliminary study by Kadir EA1, Sulaiman SA, Yahya NK, Othman NH. (PubMed)
(4) Breast cancer risk factors and age at diagnosis: an Icelandic cohort study by Tryggvadóttir L1, Tulinius H, Eyfjord JE, Sigurvinsson T. (PubMed)
Scientists may have found a sweet whole food which processes a strong effect in the prevention and treatment of breast cancer, according to some studies.
Breast cancer is a medical condition characterized by cell growth irregularly and disorderly in the breast tissue.
Most cases of breast cancer start in the cell on the surface of the inner lining of the breast tissue before spreading into deeper layers of the breast.
In the early stage, most patients with breast cancer may experience lumps on the breast or surrounding the breast.
However, breast skin irritation or dimpling, nipple pain, nipple retraction (turning inward), redness, and scaliness that cannot be healed within 3 weeks are also the signs and symptoms of breast cancer.
At the later stage, after colonizing most parts of the breast, the breast cancer cells may travel a distance far the way to infect other healthy cells and tissue.
In Canada, according to the statistic, 11% of women will develop breast cancer by the time they reach 90 years of age.
Just about 20% of breast cancers in Canada are diagnosed in women under 50, while almost 30% are diagnosed in women over 70 years of age.
These results suggested that the most common risk factor to fuel the onset of breast cancer is the increase in age.
The concern of the increasing number of studies indicates that the strength and even direction the association between breast cancer and established risk factors differ according to the woman's age when she develops the disease, Dr. Tryggvadóttir L, the lead scientist. according to the result of the study of a cohort of 80.219 women attending population-based cervical and breast cancer screening in Iceland, 1120 cases were identified, aged 26-90 years at diagnosis, and 10,537 controls, individually matched to the cases on birth year and age when attending wrote at the final report, "age at diagnosis should be taken into account when studying the effects of breast cancer risk factors".
Sadly to let you know that 60% of women who carry the genetic mutation of gene BRCA1 and 2 have breast cancer developed before the age of 70.
Other risk factors associated with the onset of breast cancer are reproductive history having a dense breast, personal and family history, previous intake of the drug diethylstilbestrol (DES), previous radiotherapy.
Regardless of all risk factors, women's breast self-examinations are still the most important methods to have breast cancer diagnosed early and increase the years of survival.
According to worldwide statistics, the 5 survival rate of the early stage of breast cancer is 100%.
Honey is a miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one healthy sweet food for replacing the use of white sugar and artificial sweetener many people.
In finding natural compounds in cancer therapy, researchers at the United Arab Emirates University conducted an experiment to test the underlying mechanism and molecular targets of manuka honey (MH) on proliferation, invasiveness, and angiogenic potential were investigated using two human breast cancer cell lines, the triple-negative MDA-MB-231 cells and estrogen receptor-positive MCF-7 cells, and the non-neoplastic breast epithelial MCF-10A cell line.
Infection of MH at concentrations of 0.3-1.25% (w/v) induced a dose-dependent inhibition of the proliferation of MDA-MB-231 and MCF-7, but not MCF-10A, cells.
At higher concentrations (>2.5%), MH was found to be generally deleterious to the growth of all three cell lines.
MH induced apoptosis of MDA-MB-231 cells through activation of proteins associated with the cell death programming and cancer cells apoptosis correlated with a loss of proteins associated with cancer cell proliferation.
Furthermore, low concentrations of MH (0.03-1.25% w/v) induced a rapid reduction in tyrosine-phosphorylated STAT3 (pY-STAT3) involved in cell growth and division in MDA-MB-231 and MCF-7 cells.
The maximum inhibition of pY-STAT3 was observed at 1 h with a loss of >80% and coincided with decreased interleukin-6 (IL-6) production.
These results suggested manuka honey (MH) inhibits breast cancer cell lines through many different mechanisms
A total of 50 nulliparous female Sprague-Dawley rats were grouped as follows: Group 0 (healthy normal rats control), Group 1 (negative control; untreated rats), Groups 2, 3, and 4 received daily doses of 0.2, 1.0, and 2.0 g/kg body weight of TH, respectively. The rats in groups 1, 2, 3, 4 were induced with 80 mg/kg of 1-methyl-1-nitrosourea (MNU) to examine the effects of Tualang honey (TH) against breast cancer.
The TH-treated rats showed a reduction of tumor progression (mean 75.3 days versus 51.5 days) compared to control.
The incidence (mean 76.6% versus 100%); the multiplicity (mean 2.5 versus 4 tumor masses per rat); the size of tumor mass (mean 0.41 cm versus 1.47 cm [p < 0.05]) and the weight of the tumor mass (mean 1.22 g versus 3.23 g; [p < 0.05]) also lower in the TH treated rats compared to control.
The grade of breast cancer is lower (I and II) compared to control (Grade III),
The efficacy of TH treatment in reducing the expression of breast cancer was attributed to the lower anti-apoptotic proteins (E2, ESR1, and Bcl-xL) expression and a higher pro-apoptotic proteins (Apaf-1 and Caspase-9) expression at serum and on the cancer tissue level.
The breast cancer size breast in the TH-treated groups was smaller mean tumor size (≤ 2 cm3) compared to Controls (≤ 8 cm3). The number of cancers developing in TH-treated groups was also significantly lower.
More importantly, an increasing trend of the apoptotic index (AI) was found in TH-treated groups with an increasing dosage of Tualang Honey compared to control.
Taken altogether, adding a portion of honey into a women's diet may have a potential effect in reducing the risk of breast cancer.
And honey may be considered an adjunct therapy combined with the primary medicine for the treatment of breast cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professional Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the Karate GB Daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The IL-6/STAT3 Signaling Pathway Is an Early Target of Manuka Honey-Induced Suppression of Human Breast Cancer Cells by Aryappalli P1, Al-Qubaisi SS1, Attoub S2, George JA1,3, Arafat K2, Ramadi KB1, Mohamed YA1, Al-Dhaheri MM1, Al-Sbiei A1, Fernandez-Cabezudo MJ3, Al-Ramadi BK. (PubMed)
(2) The anti-cancer effects of Tualang honey in modulating breast carcinogenesis: an experimental animal study by Ahmed S1,2, Othman NH. (PubMed)
(3) Inhibitory effects of Tualang Honey on experimental breast cancer in rats: a preliminary study by Kadir EA1, Sulaiman SA, Yahya NK, Othman NH. (PubMed)
(4) Breast cancer risk factors and age at diagnosis: an Icelandic cohort study by Tryggvadóttir L1, Tulinius H, Eyfjord JE, Sigurvinsson T. (PubMed)
#Herbal #Chastetreeberry Processes Anti-Hyperprolactinemia Potentially Associated with Premenstrual Syndrome, Researchers Suggest
By Kyle J. Norton
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.Hyperprolactinemia is a condition of elevated serum of prolactin which is the hormone in regulated
breast development and lactation during puberty and pregnancy, respectively.
High levels of prolactin have been found to associate with elevated symptoms in premenstrual syndrome women. Administration of herbal Chaste tree berries may ease the symptoms and treatment of mild and serve cases of PMS.
According to the Second Military Medical University, in the induced hyperprolactinemia SD rat models by administration of metoclopramide dihydrochloride (50 mg/kg, tid, ip, for 10 d), injection of casticin, a flavonoid isolated from Vitex rotundifolia in the treatment group, exhibited the reduction of (10, 20, and 40 mg/kg, ip, for 7 d) serum prolactin levels by 33.9%, 54.3%, and 64.7%,.compared untreated control group.
Dr. YE Q, the lead author in the study said, casticin ameliorated the stimulation of pituitary cells with 17β-Estradiol (E2), a female sex hormone in prolactin secretion.
The study also found that casticin at doses of 0.1, 1, and 10 micromol/L, significantly inhibited the prolactin release stimulated by 17β-Estradiol (E2) in a concentration-dependent manner., through regulating the DNA expression of estrogen receptors inactivated sex hormone for the secretion of porcelain.
In the review of pharmacology and clinical indications of the effectiveness of chaste tree berries in PMS women. the University of Göttingen found that
1. The herbal extract consisted of a beneficial influence on most common premenstrual symptoms, indicated by double-blind placebo-controlled studies.
2. Numerous less rigidly controlled studies indicated that AC extracts reduced premenstrual mastodynia by inhibiting levels of prolactin through suppressed stimulation of the mammary gland in response to stressful situations and during deep sleep phases.
Dr. Wuttke W said" The search for the chemical identity of the dopaminergic compounds resulted in the isolation of a number of diterpenes of which some clerodadienols were most important for the prolactin-suppressive effects" and "dopaminergic compounds present in Vitex agnus castus are clinically the important compounds which improve premenstrual mastodynia and possibly also other symptoms of the premenstrual syndrome".
Taking together, Chaste tree berries may be beneficial in reducing symptoms for women with PMS during the menstrual cycle, especially in hyperprolactinemia-induced premenstrual breast pain and discomfort.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton's Home page http://kylejnorton.blogspot.ca
Sources
(1) Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro by YE Q1, ZHANG QY, ZHENG CJ, WANG Y, QIN LP. (PubMed)
(2) Chaste tree (Vitex agnus-castus)--pharmacology and clinical indications by Wuttke W1, Jarry H, Christoffel V, Spengler B, Seidlová-Wuttke D.(PubMed)
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