Queen Herb Chaste Tree Berry Protects and Restores Internal Eye Structures Against Cataract Formation, Scientists Find

Kyle J. Norton

Today, many whole herb ingredients worked together in herbal plants were proven effective in reduced risk and treatment of various diseases with little or no side effects by many respectable scientists through intensive research and studies. However, intake of synthetic versions of single-ingredient isolated from such plants may produce opposite outcomes.

A recent study suggested that chaste Tree Berry may be used to protect the internal structures of the eyes against selenite-induced cataractogenesis.

Selenite cataract is a rapidly-induced, convenient model for the study of age-related (senile) cataracts.

Selenite, named from the Ancient Greek word for the Moon. is a crystal-like substance of mineral gypsum, composed of calcium sulfate dihydrate. It is one of the Chinese herbs used for the treatment of heat and fire syndromes.

Long-term contact with the crystal may cause side effects of headache, unstable emotional expression,..... and dizziness.

Cataractogensis is a process of cataract formation.

Cataract, one of common vision loss in people over age 40 and a leading cause of blindness, is a condition of blur vision caused by clouding of the lens in one or both eye(s).

According to statistics provided by Laser Eye Surgery Hub, In England, 30% of people 65 years or older have a visually impairing cataract in one or both eye(s). 10% of people 65 or over had already had cataract surgery. 95% of cataracts are age-related, usually after age 40.

There are many causes of cataracts, some researchers suggested that aging and injury that cause the changes in the tissue made up the eye's lens, past eye surgery, or medical conditions such as diabetes are the common causes of the disease.

However, some inherited genetic disorders such as chromosome abnormalities, Lowe syndrome,,,,

and neurofibromatosis type 2, also are associated to increase risk of cataracts too.

Believe it or not, cataracts can also be caused by other eye conditions.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belongings to the family Lamiaceae, native to the Mediterranean region.

The herb has been used in herbal medicine for thousands of years as an aphrodisiac herb and considered a Queen herb in treating menstrual problems and discomforts.


According to the University of Kerala, flavonoids found in the chaste tree berry exerted a cataract protective effect in prevented damage of lenticular membrane and abnormal fiber structure in patients with cataract viewed through electron microscopy.

Furthermore, the study also found that chaste tree berry expresses a significant improvement of chaperone property of α-crystallin and soluble protein levels in two-dimensional-polyacrylamide gel electrophoresis (2D-PAGE) and immunoblot analysis.

α-crystallin, a structural lens protein plays an important role in protecting the eyes against the formation of eye diseases, including cataracts.

Dr. Rooban BN, the lead author said, " FVN modulated selenite induced cataractogenesis in rat pups by preventing loss of chaperone property, various changes in lens proteins, and lens structure, further strengthening its protective role".

Some researchers suggested that the efficacy of chaste tree berry in reduced risk and treatment of cataract may be a result of phytochemical antioxidants activity in scavenging free radicals that cause oxidative stress, loss of calcium homeostasis, calpain activation, and protein insolubilization.

More importantly, in a study of eight-day-old Sprague-Dawley rat pups divided into four groups: Control (G I), Sodium selenite-induced (G II), Sodium selenite+quercetin treated (G III), Sodium selenite+flavonoids from Vitex negundo (FVN) (G IV), group fed with sodium selenite+flavonoids showed normal levels of expression of the lens of water-soluble proteins in compared to other groups.

In fact, pups treated with FVN was found to exhibit the antioxidant effects in modulating biochemical parameters against selenite-induced cataract, the University of Kerala insisted.

In support to the above differentiation, the Sprague-Dawley rat pups of 8 days old divided into control (G I), selenite induced (G II), and selenite + V. negundo treated (G III) with cataract induced by the single subcutaneous injection of sodium selenite (4 mg/kg body weight) on the tenth day and V. negundo (2.5 mg/Kg body weight) administered intraperitoneally from eighth to 15th-day study, researchers showed that group III exerts significantly reduced activities of superoxide dismutase, catalase, lower level of reactive oxygen species, Ca(2+), and thiobarbituric acid reactive substance.

Taking together, Chaste tree berry may process therapeutic potential used for prevention of changes of internal eye structures that stimulated onset of cataract and treatment of cataract with little adverse effects.

However, additional large sample size and multi-center clinical trials with human consumption during the course of the disease are necessary to re-confirm chaste tree berry anti cataract possibility.


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Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal of Pharma and Bioscience, ISSN 0975-6299.



Sources
(1) Analysis on the alterations of lens proteins by Vitex negundo in selenite cataract models by Rooban BN1, Sasikala V, Sahasranamam V, Abraham A.(PubMed)
(2) Vitex negundo attenuates calpain activation and cataractogenesis in selenite models by Rooban BN1, Lija Y, Biju PG, Sasikala V, Sahasranamam V, Abraham A.(PubMed)

Arnica's Bioactive Sesquiterpene Lactones Block the Spreading of Leukemia Cells, Scientists Find

By Kyle J. Norton

Arnica may have a substantial and sustainable effect in reducing the risk, progression, and treatment of leukemia, some scientists suggested.

The results of these reports were conducted by a number of respectable institutes, including the Chonnam National University and Westfälische Wilhelms-Universität, and published online on the database of medical literature.

Leukemia is a medical condition characterized by cell growth uncontrollable and disorderly produced by the body's blood-forming tissues, including the bone marrow and the lymphatic system. In most cases, it is the result of abnormal white blood cells, which don't function properly.

According to reliable statistics, approximately every 3 minutes one person in the United States (US) is diagnosed with leukemia. New cases of leukemia, lymphoma, and myeloma are expected to account for 10 percent of 1,735,350 new cancer cases diagnosed in the US in 2018.

The exact causes of leukemia are unknown. However, certain risk factors including smoking, mutation gene inherited from parents such as Down syndrome. blood disorders such as myelodysplastic syndrome are associated with an increased risk of the disease.

Some researchers also suggested that people who have previous treatment for cancer with chemotherapy or radiation are at higher risk of cancer development.

Most common symptoms of leukemia include fever or chills, persistent fatigue and weakness frequent or severe infections due to dysfunction of the immune system caused by immature white blood cells produced.

Some patients may also experience symptoms of unattended weight loss, swelling lymph nodes,... and enlarged liver or spleen.


If you experience some of the above symptoms, please check with your doctor to rule out the possibility.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is a process of repairing after the damage of the skin, tissues, organs, etc.

Leukemia is a chronic condition characterized by high numbers of abnormal white blood cells in the bone marrow.

The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.

In the investigation of the effect of helenalin, a bioactive chemical compound isolated from Arnica on the human promyelocytic leukemia HL-60 cell line, researchers found that application of the compound exerts a significant effect in induced HL-60 cell differentiation through the expression of granulocytes, white blood cells with secretory granules in its cytoplasm, at a concentration-dependent manner.

Further analysis, injection of helenalin inhibited HL-60 through activating the protein kinase C (PKC) inhibitor with a function to act as ruboxistaurin in signaling molecules that link to multiple cellular processes of cancer.

Moreover, researchers also found that helenalin also inhibits HL-60 proliferation through activating the extracellular signal-regulated kinase (ERK) inhibitors which are used in some cancer therapy in controlling diverse tumor cellular processes such as proliferation, survival, and motility.



Protein kinase C (PKC) is a family of protein kinase enzymes with the function of controlling the expression of other proteins through certain mechanisms.

Additional differentiation also suggested that helenalin induced expression of protein kinase C (PKC) inhibitors without interfering with PKC activity and protein level of PKC beta I and PKC beta II isoforms activities which have been found to promote progression of human cancer.

Interestingly, helenalin also inhibited HL-60 through increasing levels of protein kinase R-like endoplasmic reticulum kinase (PERK) with the function of triggering cancer cell death in a concentration-dependent manner.


Finally, researchers also indicated that the inhibition of HL-60 by helenalin is also carried out through ameliorating levels of NF-kappa, with aberrant activity in enabling leukemia cells to evade apoptosis and stimulate proliferation.

High levels of NF-κB have been detected in most of the patients with acute myeloid leukemia (AML).


These results postulated that helenalin isolated from Arnica inhibits the expression of human promyelocytic leukemia HL-60 cell line through many different pathways involved several aspects in tumor cellular differentiation.

More importantly, in the different aspects of the study, Dr. Dirsch VM and colleagues found that sesquiterpene lactones also exerted a significant cytotoxic effect in triggering leukemia cell apoptosis.

According to cell morphology, four compounds found in sesquiterpene lactones, including ambrosin, alantolactone, hymenin, and helenalin induced apoptosis of Jurkat leukemia T cells, individually, through inducing apoptosis of nuclei and the outer surface of the cell membrane.

Taken together, Arnica and its bioactive sesquiterpene lactones, particularly helenalin may be used to ameliorate the risk, progression, and treatment of Leukemia.

However, additional data collection on large example size and multi-centers studies performed with human consumption of herbal arnica or its' bioactive sesquiterpene lactones during the course of the disease will be necessary to complete the picture of garlic anti-leukemia possibilities.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone by Kim SH1, Oh SM, Kim TS. (PubMed)
(2) Cytotoxic sesquiterpene lactones mediate their death-inducing effect in leukemia T cells by triggering apoptosis by Dirsch VM, Stuppner H, Vollmar AM. (PubMed)

Calendula (Calendula officinalis) Together with Eyelid Hygiene Are Effective for Patients with Chronic Blepharitis, According to Studies

By Kyle J. Norton

Herbal Calendula may have a potential effect in reducing the risk and treatment of chronic blepharitis, some scientists suggested.

Blepharitis is a condition caused by the eye inflammation of the eyelids or parts of the eyelids as a result of clogging of tiny oil glands located near the base of the eyelashes, affecting people of all ages.

Blepharitis can be classified into 2 types1. Acute blepharitis is referred to as eyelid infection by bacterial, viral, or parasitic pathogens.

2. Chronic blepharitis or lid inflammation is caused by staphylococcal, seborrheic, and meibomian gland dysfunction (MGD) that lasts more than 3 months.

According to researchers, chronic blepharitis is difficult to treat due to persistently low-grade inflammation.

The most common causes of blepharitis are bacterial infections. However, the condition also can be caused by a skin condition, such as scalp dandruff or rosacea.

If you experience symptoms of itchiness, redness, flaking, and crusting of the eyelids, burning sensation, irritation, tearing, and red eyes, you may have acute blepharitis, please check with your doctor.


Untreated chronic blepharitis can lead to permanent alterations to the eyelid margin or vision loss from superficial keratopathy (abnormality of the cornea), corneal neovascularization, and ulceration.

Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.


The herb has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.


Chemical ingredients
Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.

In the findings of the natural ingredient with potential for the treatment of chronic blepharitis without inducing any adverse effects, Dr. Prozornaia LP and Dr. Brzhevskiĭ VV.launched an investigation to examine the herbal Calendula anti chronic blepharitis activity.

In the total of 110 patients aged from 3 to 42 years old were examined to estimate the efficacy of chronic blepharitis treatment, 50 patients are with chronic blepharitis and dry eye syndrome (DES), 28 are with DES due to computer vision syndrome and 32 are with isolated chronic blepharitis.

All patients received eyelid massage and a complex of hygienic procedures was performed using phytoproducts ("Geltec-Medika", Russia): blepharoshampoo, blepharolotion, blepharogel 1 and 2.

After all the procedures were finished, moist warm pads (with blepharolotion and calendula extraction) were applied on the eyelids in 25 patients.

In comparison to massage, moist warm pads treatment exerts a significant effect in the improved efficacy of background therapy in patients with meibomian gland hypofunction but the insignificant effect in patients with excessive meibomian gland secretion.

These results suggested that Herbal Calendula may be effective in the treatment of chronic blepharitis caused by meibomian gland hypofunction if it is used in conjunction with eyelid hygiene.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) [Efficacy of physiotherapy and hygienic procedures in the treatment of adults and children with chronic blepharitis and dry eye syndrome].[Article in Russian] by Prozornaia LP, Brzhevskiĭ VV.(PubMed)
(2) Interventions for chronic blepharitis by Kristina Lindsley,1 Sueko Matsumura,1 Elham Hatef,2 and Esen K Akpek. (PubMed)

Papaya Extract and Fermented Papaya Process Anti Diabetes Activity in Vivo and Clinical Diagnosis

By Kyle J. Norton

Papaya may be the next potential target of pharmacological companies to identify the ingredients for the treatment of type 2 diabetes, some scientists suggested.

Diabetes is a chronic and low-grade inflammatory disease caused the insufficient insulin entering the bloodstream to neutralize the levels of glucose due to insulin resistance.

There are many causes that facilitate the insufficient levels of insulin produced by the body.

Some researchers suggested it is either caused by cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. and in some cases, insulin resistance is also caused by allergic reactions of cells in the immune system.


Is diabetes a low-grade inflammatory disease, Dr. Yansong ZHENG, in the answer to the above question said, " Chemicals from the fat cells could lead to inflammatory response and the levels of certain inflammatory chemicals are often higher in people with T2D compared to people without diabetes as well. Inflammatory responses contribute to the development of T2D and some even insinuated that T2D is actually inflammatory disease".


Moreover, in this review of the interconnection between obesity, inflammation, and insulin resistance and pro-inflammatory cytokines cause insulin resistance in adipose tissue, skeletal muscle, and liver by inhibiting insulin signal transduction., Dr. Carl de Luca, the lead author at the University of California, wrote, "The sources of cytokines in insulin-resistant states are the insulin target tissue themselves, primarily fat and liver, but to a larger extent the activated tissue-resident macrophages"


"While the initiating factors of this inflammatory response remain to be fully determined, chronic inflammation in these tissues could cause localized insulin resistance via autocrine/paracrine cytokine signaling and systemic insulin resistance via endocrine cytokine signaling all of which contribute to the abnormal metabolic state.

These results indicated a strong relationship between chronic low-grade inflammation and diabetes caused by the immune mistakenly targets the tissues of adipose tissue, skeletal muscle, and liver in the initiation of insulin resistance, the major cause of diabetes onset.


Papaya is a species of Carica Papaya, belongs to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries

Chemical constituents of papaya include
Alkaloids, Cardenolides, Anthraquinones, Saponins, Tannin, phenol, flavonoid, anthocyanin, Benzyl glucosinolate, benzyl isothiocyanate, 5-(Hydroxymethyl)-2-furancarboxaldehyde, 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and 1,3-dihydroxy-2-propanone, etc.

In the reaffirming of the use of unripe pawpaw (Carica papaya Linn) fruit for the management or treatment of diabetes mellitus in folklore medicine.,researchers launched an investigation to examine the inhibitory effects of the aqueous extract of different parts of unripe pawpaw fruit on key enzymes linked to type 2 diabetes (α-amylase and α-glucosidase) and sodium nitroprusside (SNP)-induced lipid peroxidation in rat pancreas in vitro.


All the extracts from papaya exerted a strong effect in the inhibition of α-amylase (IC50=0.87-1.11 mg/mL), α-glucosidase (IC50=1.76-2.64 mg/mL) and SNP-induced lipid peroxidation (IC50=1.99-2.42 mg/mL) in a dose-dependent manner.

The combination of the flesh, seed, and peel in equal amounts had the highest inhibitory effect on α-amylase and α-glucosidase activities compared to extract-treated rats.

Dr.Oboh G, after taking into account co and confounders, said, "Strong inhibitory activities of the unripe pawpaw fruit against key enzymes linked to type 2 diabetes and SNP-induced lipid peroxidation in rat pancreas could be part of the mechanism by which unripe pawpaw is used in the management/prevention of diabetes mellitus in folk medicine".

Furthermore, in the study involving diabetes induced in rats by intraperitoneal administration of 60 mg/kg of streptozotocin (STZ) followed by the administered aqueous extract of C. papaya in three different doses (0.75, 1.5, and 3 g/100 mL) as drinking water to both diabetic and non-diabetic animals during 4 weeks.

After examining the blood samples collected from the treatment group compared to the non-diabetic group, the researcher found that
* The aqueous extract of Carica papaya (0.75 g and 1.5 g/100 mL) significantly decreased blood glucose levels (p<0.05) in diabetic rats.

* Low plasma insulin levels did not change after treatment in diabetic rats, but they significantly increased in non-diabetic animals.

* Pancreatic islet cells were normal in non-diabetic treated animals, whereas in diabetic treated rats, C. papaya could help islet regeneration manifested as the preservation of cell size.

* In the liver of diabetic treated rats, C. papaya prevented hepatocyte disruption, as well as accumulation of glycogen and lipids.

* An antioxidant effect of C. papaya extract was also detected in diabetic rats.

Dr. Juárez-Rojop IE, the lead authors said, "aqueous extract of C. papaya exerted a hypoglycemic and antioxidant effect; it also improved the lipid profile in diabetic rats. In addition, the leaf extract positively affected the integrity and function of both liver and pancreas"


These results suggested that the aqueous extract of Carica papaya exerts a significant inhibitory effect in diabetes rats through mechanisms involving many aspects.


A short-term study by the University of Mauritius, also found that supplementation of fermented papaya also exhibited the antihyperglycemic effect in the management of diabetes and for those at risk for cardiovascular disease, neurological disease, and other conditions worsened by overt inflammation and oxidative stress.

Taken all together, papaya may be considered a functional food for the prevention and adjunct therapy for the treatment of diabetes through its antihyperglycemic activity without inducing any adverse effects


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside-induced lipid peroxidation in rat pancreas by water-extractable phytochemicals from unripe pawpaw fruit (Carica papaya). by Oboh G, Olabiyi AA, Akinyemi AJ, Ademiluyi AO. (PubMed)
(2) Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats by Juárez-Rojop IE1, Díaz-Zagoya JC, Ble-Castillo JL, Miranda-Osorio PH, Castell-Rodríguez AE, Tovilla-Zárate CA, Rodríguez-Hernández A, Aguilar-Mariscal H, Ramón-Frías T, Bermúdez-Ocaña DY. (PubMed)
(3) Relationship between Type 2 Diabetes and Inflammation Diseases: Cohort Study in Chinese Adults by Yansong ZHENG,1 Guilan ZHANG,2 Zhilai CHEN,1 and Qiang ZENG. (PMC)

Banana, the Tasty Fruit Is Found to Process Anti-Hypertension Property, According to Clinical Diagnosis

By Kyle J. Norton

Scientists may have found an inexpensive whole fruit for the prevention and treatment of hypertension with no side effects, some studies found.

Banana is the common name of a genus of tropical herbaceous plants. It can grow from 3 to 9 m and belongs to the family of the lily and the orchid.

Hypertension is a medical condition characterized by abnormally high blood pressure. one of the preventable risk factors of heart disease associated with the cluster of metabolic syndrome.

In other words, high blood pressure means raising the pressure in your heart. the condition can be acute or chronic.

Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood.

Chronic high blood pressure epidemiologically can damage the arteries and causes blood clots to form in the arteries, blocking the blood flow and contributing to the onset of cardiovascular and neuro diseases.

Although certain chronic conditions such as kidney disease are found to associate with chronic hypertension which can only be treated by addressing the usable condition, the syndrome in the Western world is mostly a result of unhealthy diet and obesity.

According to a joint study led by the Tecnológico de Monterrey, that examined the effects of Western and Modern Mexican dietary patterns and the incident hypertension in Mexican women, the comparison of participants who followed the diet loaded heavily with vegetables, fruits, and legumes and who follow the Western and Modern Mexican dietary patterns loaded heavily with processed meats, fast foods, and red meat; and finally the third component was loaded heavily with corn tortillas, hot peppers, and sodas suggested that

* The multivariable-adjusted odds of hypertension in the highest quartile of the W pattern were 24% higher than the odds for individuals in the lowest quartile.


* Women in the highest quartile of the MM pattern had 15% higher odds than women in the lowest quartile.

* And The Fruits & Vegetables (FV) pattern was not significantly associated with hypertension.


These results strongly indicated high blood pressure can be prevented by following a healthy diet with high fruits and vegetables, whole grain and low saturated and trans fat, red meat, and processed foods.

On finding a natural chemical compound or whole food for the prevention and treatment of hypertension, researchers evaluate the corosolic acid (CRA) antihypertensive activity, a constituent of banana leaves.

The experiment included Six-week-old male SHR-cp rats, an animal model of metabolic syndrome were fed a high-fat diet containing 0.072% CRA for 14 weeks.
Treatment with CRA lowered blood pressure, which was elevated in control animals, by 10% after 8 weeks, and serum-free fatty acids by 21% after 2 weeks.

Oxidative stress markers thiobarbituric acid-reactive substances and 8-hydroxydeoxyguanosine in the tested animal were also decreased by 27% and 59%, respectively, after 2 weeks.

Furthermore, CRA treatment also reduced the levels of myeloperoxidase markers, 3-nitrotyrosine, and 3-chlorotyrosine, by 38% and 39%, respectively, after 10 weeks, and decreased the levels of high sensitivity C-reactive protein, markers of inflammation, after 6 weeks.

The presence of a marker of inflammation is the indication of inflammation.

These results clearly suggested that CRA ameliorate hypertension, and oxidative stress caused by the inflammation in SHR-cp rats.

Dr. Yamaguchi Y, the lead scientist said, "CRA can be beneficial for preventing atherosclerosis-related diseases that are an increasing health care problem worldwide".


Moreover, In a human study to test the effect of banana on cold stress-induced hypertension, peak expiratory flow rate, and plasma ACE activity, researchers showed that

*Banana treatment reduced the systolic blood pressure (P < 0.005), diastolic blood pressure (P < 0.025), and mean arterial blood pressure (P < 0.005) during cold stress in healthy volunteers compared to controls.

* There were no significant changes in heart rate and peak expiratory flow rate but only a significant decrease in plasma angiotensin-converting enzyme activity after banana treatment.


Levels of plasma angiotensin-converting enzyme are high in patients with hypertension.

Dr. Sarkar C, the lead scientist said' "Banana decreased the rise of systolic blood pressure and diastolic blood pressure in healthy volunteers subjected to cold stress test without much effect on heart rate and peak expiratory flow rate".

Taken altogether, bananas may be considered a functional fruit for the prevention and treatment of hypertension with no side effects.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Corosolic acid prevents oxidative stress, inflammation, and hypertension in SHR/NDmcr-cp rats, a model of metabolic syndrome by Yamaguchi Y1, Yamada K, Yoshikawa N, Nakamura K, Haginaka J, Kunitomo M.(PubMed)
(2) Effect of banana on cold stress test & peak expiratory flow rate in healthy volunteers by Sarkar C1, Bairy KL, Rao NM, Udupa EG. (PubMed)
(3) Western and Modern Mexican dietary patterns are directly associated with incident hypertension in Mexican women: a prospective follow-up study by Adriana Monge,1,2 Martín Lajous,1,4 Eduardo Ortiz-Panozo,1 Beatriz L. Rodríguez,2,3José Juan Góngora,2 and Ruy López-Ridaura. (PMC)

Herbal Calendula May Process Anti Cancers Property, Scientists Find

Kyle J. Norton

Scientists may have found a herbal remedy for the prevention and treatment of cancer, according to the studies.

Cancer is the class of diseases associated with irregular cell growth in some specific tissues and organs due to the alternation of cell DNA.

Depending on the stage and specific types of cancer, some cancers do not cause any symptoms such as liver cancer.

However, at the later stage, the larger size of the tumor may suppress the nearby blood vessels and nerve cells, leading to localized bleeding and pain accompanied by the general symptoms shared by other types of cancer.

At this stage, cancer cells may also travel a distance away from the original site to infect other healthy tissues and organs through fields and blood circulation, leading to secondary metastasis.

There are some common factors shared by many types of cancer such as family and personal history, ethnicity, and gender, some researchers found that an unhealthy lifestyle is one of the major risks in the induction of the diseases.

Dr. Katzke, Verena A Ph.D., the lead scientist in the concern of lifestyle and cancer risk, wrote, "Lifestyle factors, such as smoking, alcohol consumption, obesity, diet, and physical inactivity, and also reproductive and hormonal factors are considered as causes of cancer and main targets for primary prevention".

And, " While smoking, which may be responsible for around 20% to 30% of all incident cancers, is clearly the strongest lifestyle-related risk factor overall, followed by alcohol consumption and obesity, the importance of specific factors for individual cancer types and subtypes varies greatly.".


In other words, by changing to a healthy lifestyle, the risk of cancers can be reduced substantially.

Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.

The herb medicine has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.

Besides major chemical constituents of triterpenoids, flavonoids, coumarins, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin, and n-paraffins.

Researchers on finding natural chemotherapy for the treatment of cancer investigated the cytotoxic anti-tumor and immunomodulatory activities and in vivo antitumor effect of Laser Activated Calendula Extract (LACE), a novel extract of the plant Calendula Officinalis (Asteraceae).

The tumor cell lines included in the study are derived from leukemias, melanomas, fibrosarcomas, and breast, prostate, cervix, lung, pancreas, and colorectal cancer.


The LACE extract showed a potent in vitro inhibition of tumor cell proliferation in a wide variety of human and murine tumor cell lines, ranged from 70 to 100%.
The cancer cell inhibition was attributed to the protein associated with a cell cycle arrest in G0/G1 phase and induced apoptosis.

Furthermore, the intraperitoneal injection or oral administration of LACE extract in nude mice inhibits in vivo tumor growth of Ando-2 melanoma cells and prolongs the survival day of the mice.

However, human peripheral blood lymphocyte (PBL) and NKL cell lines, lACE extract exerted an opposite effect.

These results suggested that LACE aqueous extract has 2 potential anti-tumor therapeutic effects: cytotoxic tumor cell activity and lymphocyte activation on selected cancer cell lines.

Moreover, in male mice injected with B16F-10 melanoma cells through the tail vein and simultaneously treated with C.officinalis flower extract. researcher showed that
* Simultaneous administration of C. officinalis extract to tumor-bearing C57BL/6 mice reduced the lung tumor nodules by 74% with a 43.3% increase in lifespan

* Elevated levels of inflammatory expression including the proinflammatory cytokines were found to be significantly lowered in the C. officinalis treated animals.


* The extract also inhibited the expression of the matrix and enzymes associated with cancer proliferation and activated the family protein associated with the modulation of cancer cell transcriptional profile.

Taken altogether, herbal Calendula may be considered a safe functional remedy for the prevention and combined with primary medicine for the treatment of cancers with no side effects, pending the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References(1) Screening the antiangiogenic activity of medicinal plants grown and sold in Jordan by Zihlif M1, Afifi F, Muhtaseb R, Al-Khatib S, Abaza I, Naffa R.(PubMed)
(2) A new extract of the plant Calendula officinalis produces a dual in vitro effect: cytotoxic anti-tumor activity and lymphocyte activation by Jiménez-Medina E1, Garcia-Lora A, Paco L, Algarra I, Collado A, Garrido F.(PubMed)
(3) Inhibition of metastasis of B16F-10 melanoma cells in C57BL/6 mice by an extract of Calendula officinalis L flowers by Preethi KC1, Siveen KS, Kuttan R, Kuttan G.(PubMed)
(4) Lifestyle and Cancer Risk by Katzke, Verena A Ph.D.; Kaaks, Rudolf Ph.D.; Kühn, Tilman Ph.D. (The Cancer Journal)

Herbal Cascara Sagrada May Process Anti Breast Cancer Activity, Researchers Say

By Kyle J. Norton

Herbal Cascara sagrada may be the next generation of natural chemotherapy for the treatment of breast cancer, according to studies.

Breast cancer is a medical and chronic condition characterized by cell growth irregularly due to the alternation of DNA.

Most cases of breast cancer start in the cells on the surface of the inner lining of the breast tissue, including the milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

At the advanced, the large tumor may press on the nearby blood vessels and nerve cells, leading to bleeding and severe pain. Cancer cells from the breast can also travel a distance away to infect other healthy tissue and organs at this stage.

The most common breast cancer secondary metastasis is the liver, brain, bones, or lungs.

According to the statistics, in 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during a lifetime of a woman is 1/8.

Researchers do not know the exact causes of breast cancer. However, family and personal history, women with dense breast tissue, use of hormone replacement therapy and oral contraceptives, genetic preposition, particularly BRCA1 and 2, tall adult heigh are some prevalent risk factors of the disease.

Some researchers suggested that the increase in the prevalence of breast cancer in overweight and obesity is also a major concern of the scientists' community.

Dr. Manuel Picon‐Ruiz, the lead scientists in the observation of obesity in the risk of breast cancer wrote, "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages" and "... the effects of obesity to increase local and circulating proinflammatory cytokines, promote tumor angiogenesis and stimulate the most malignant cancer stem cell population to drive cancer growth, invasion, and metastasis".

And, "The effects of recent lifestyle interventions to decrease sex steroids, insulin/insulin‐like growth factor‐1 pathway activation and inflammatory biomarkers associated with worse breast cancer outcomes in obesity also are discussed. Although many observational studies indicate that exercise with weight loss is associated with improved breast cancer outcome".

The results strongly suggested that the risk of breast cancer is significantly elevated in the obese population compared to healthy adults.

Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, it's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.

The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C, and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.

Researchers on clarification of the effects of a bioactive ingredient emodin found abundantly in herbal Cascara Sagrada and Rhubarb. against breast cancer, examined the compound activity on estrogen receptor α (ERα).

The application of emodin demonstrated the capability in inhibiting breast cancer cell proliferation by suppressing the ER α protein levels, through blocking the ER α transcriptional activation.

Furthermore, emodin treatment led to the dissociation of heat shock protein 90 (HSP90) which plays a critical role in stabilizing the proteins against heat stress and ER α and increased ER α ubiquitination in initiation cell degradation.


Dr. Huang PH and colleagues in the final report wrote, "emodin,....specifically suppress breast cancer cell proliferation by targeting ER α protein stability through distinct mechanisms".


In order to reveal the additional information of emodin in the inhibition of breast cancer, researchers investigated the anticancer effects of emodin on growth inhibition, apoptosis induction, and the expression of apoptosis-related genes in MCF-7 cells.


Emodin showed significant growth inhibitory effects on MCF-7 cells with IC₅₀ = 7.22 µg/ml (∼30 μM) and exerted a concentration-dependent inhibitory effect on the colony-forming ability of MCF-7 cells with IC₅₀ = 7.60 µg/ml (∼30 µM).

The bioactive compound induced breast cancer death observed by the single-strand DNA breakage and DNA fragmentation, in emodin-treated MCF-7 cells.

Moreover, emodin efficacy in causing breast cancer cells apoptosis was attributed to the activation of the gene expression involved the modulation of the immune response to stress and inhibition of the proteins associated with cancer cell proliferation and survival.


Dr. Li WY, the lead scientist after taking into account co and confounders said, "emodin could induce growth inhibition and apoptosis in MCF-7 cells through the modulation of the expression of apoptosis-related genes".

Taken altogether, herbal Cascara Sagrada (Rhamnus purshiana) processed bioactive emodin may be considered a functional remedy for the prevention and combined with primary therapy for the treatment of breast cancer, pending the confirmation of a large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as the international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition, by Huang PH, Huang CY, Chen MC, Lee YT, Yue CH, Wang HY, Lin H.(PubMed)
(2) Synergistic effects of curcumin with emodin against the proliferation and invasion of breast cancer cells through upregulation of miR-34a. by Guo J, Li W, Shi H, Xie X, Li L, Tang H, Wu M, Kong Y, Yang L, Gao J, Liu P, Wei W, Xie X.(PubMed)
(3) Emodin induces cytotoxic effect in human breast carcinoma MCF-7 cell through modulating the expression of apoptosis-related genes by Li WY, Chan RY, Yu PH, Chan SW. (PubMed)
(4) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, Ph.D., 1 Cynthia Morata‐Tarifa, Ph.D., 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, Ph.D. (PMC)