Tocopherols Protects the Liver Against Liver Toxicity in Vitro

By Kyle J. Norton


The liver is a large internal organ of the human body that protects us by filtering the blood that comes from the digestive system before passing to other parts of the body.

In other words, if the liver was damaged due to toxicity, the blood will be toxic, affecting the function of all organs and tissues in the body.

Epidemiological studies suggested liver dysfunction can also induce acute kidney injury (AKI), chronic kidney disease, linked to the increased mortality, extending to those with chronic liver disease.

Hepatotoxicity is a condition caused by the accumulation of toxin in the liver, leading to liver dysfunction or reduced liver function.

Acute liver toxicity is caused by short-term exposure to toxic chemicals such as an overdose of medication.

The most common symptoms of liver toxicity are jaundice, persistent itching, and abdominal pain.

Some patients may also experience symptoms of pain in the upper right portion of the abdomen fatigue, loss of appetite accompanied by gastrointestinal discomforts.

Chronic liver toxicity is due to long-term exposure to toxic substances including excessive alcohol drinking and long term use of certain medicines.

Liver damage can be hepatocellular caused by direct hepatotoxicity, or innate and adaptive immune responses, and cholestatic caused most commonly by the drug or the drug metabolite, or mixed.

Liver damage can lead to reduced function of liver hepatobiliary transporter systems that affects the bile formation and secretion of oleophilic substances and xenobiotics.

In the US, the most common causes of liver toxicity are the results of the most common drug-induced liver injury including overdoses of acetaminophen.

Believe it or not, antibiotics are the most common cause of liver toxicity.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of liver diseases, researchers examined the liver protective effect of antioxidant vitamins such as L-Ascorbic acid (L-AA) and α-Tocopherol (α-TOC) on As2O3 induced liver toxicity.

According to the analysis of immortalized human Chang liver cells.
* L-AA (100 µM) and α-TOC (50 µM) recovered As2O3 (10 µM) cytotoxicity

* As2O3 treatment showed an increase in lipid peroxidation and depletion in antioxidant status, mitochondrial transmembrane potential, and values of total antioxidant capacity.

* However, the Cotreatment of antioxidant vitamins with As2O3 resulted in a significant reversal of oxidative stress markers.

In other words, L-Ascorbic acid (L-AA) and α-Tocopherol (α-TOC) exerted a liver protective effect against As2O3 against liver toxicity.

After talking about other factors into account, researchers said, ". Our findings substantiate the effect of antioxidant vitamins in protecting the hepatocytes from oxidative stress which may be attributed through Nrf2 (Nuclear factor erythroid 2-related factor 2) mediated upregulation of Bcl2 (B-cell lymphoma 2) expression".

Taken altogether, tocopherols used alone or combined with lycopene may be considered adjunct therapies in the prevention of liver toxicity, pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) L-Ascorbic Acid and α-Tocopherol Reduces Hepatotoxicity Associated with Arsenic Trioxide Chemotherapy by Modulating Nrf2 and Bcl2 Transcription Factors in Chang liver Cells by Vineetha RC1, Archana V1, Binu P1, Arathi P1, Nair RH. (PubMed)

Coltsfoot(Tussilago farfara) Processes Anti-Microbial Activity

By Kyle J. Norton

Infectious diseases are a medical condition caused by pathogenic microorganisms, including bacteria, viruses, parasites or fungi.

Most cases of infectious diseases are contagious by spreading directly or indirectly, from one person to another.

In other words, if you kiss, or are coughed or sneezed on by an infectious person, you are at risk of developing the same infectious disease.

After entering the body, the organisms selectively find a specific tissue or organ to start their multiplication.

However, the acquired infectious diseases can also be caused by ingesting contaminated food or water or being exposed to organisms in the environment.

According to the statistics provided by the World Health Organization, 3 infectious diseases were ranked in the top ten causes of death worldwide in 2016.

More precisely, lower respiratory infections, diarrheal diseases, and tuberculosis induced 3.0 million, 1.4 million, and 1.3 million deaths, respectively.

Antibiotics are a group of conventional medicines used for the treatment of bacterial, fungal parasitic,... infection.

Most organisms before having a chance to induce infection are killed off by the immune system response in the acute phase of infection, by stimulating the production of a proinflammatory cytokine.

On finding a natural compound for the prevention and treatment of infectious diseases, researchers examined the antimicrobial activity of ethanolic extracts of Tussilago farfara L. 

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

Selected strains of bacteria such as Escherichia coli CCM 3988, Serratia rubidea CCM 4684, Staphylococcus epidermis CC 4418, Lactobacillus rhamnosus CCM 1828, Pseudomonas aeroginosa CCM 1960 and Enterococcus raffinosus CCM 4216 were used in the examination.

According to the results of the analysis, ethanolic extracts of Tussilago farfara L.showed the most antibacterial effect on Grampositive bacteria Lactobacillus rhamnosus, compared to the lowest inhibitory activity on yeast Saccharomyces cerevisiae.

However, on the micro broth dilution technique, the ethanolic extract exerted a significant effect against Saccharomyces cerevisiae and Serratia rubidaea.

In other words,  the ethanolic extract of Tussilago farfara L. demonstrated a strong anti-microbial property against all the strains used in the study.

Taken altogether, coltsfoot may be considered a remedy for the prevention and treatment of microbial infections, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1)
Antimicrobial activity of Tussilago farfara L by Miroslava Kačániová, Lukas Hleba, Jana Petrová, and  Soňa Felšöciová. (Science Direct)

Green bean Processes Antiplatelet Activity Against the Risk Of CVD

By Kyle J. Norton

Platelet aggregation is a condition of platelets clumping together in the blood. In most cases, the process is to protect the vascular injury against bleeding and microbial pathogenic invasion.

In other words, platelet aggregation is stimulated by the first-line immune response after sensing bodily injury or damage accompanied by the production of pro-inflammatory cytokines to defend
the injured area against infection.

Platelet disorders can lead to abnormal bleeding. Most common types of genetic proposition of platelet disorders including disorder of platelet adhesion, aggregation, secretion, and procoagulant activity.

If your blood platelet count falls below the normal range from 150,000 to 450,000 platelets per microliter of circulating blood, you are considered thrombocytopenia.

Believe it or not, platelet count that falls below 10,000 platelets per microliter are dangerous. Epidemiologically, severe thrombocytopenia can be fatal.

 Most common symptoms of platelet disorders are unexplained bruising throughout the body, bleeding from your nose, mouth, or gums, under your skin, muscles, and joints and heavy or prolonged menstrual bleeding,

In severe cases, patients may also experience symptoms of vomiting blood,  blood in your feces and internal bleeding.

Conventionally, most common medication with blood-thinning activity such as aspirin (ASA) and other drugs containing aspirin non-steroidal anti-inflammatory drugs and some antibiotics may have a strong implication of the formation of platelets coagulation.

Green bean is a genus of Phaseolus Sensu Stricto, containing 55 difference species, belongings to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. The veggie can be classified into two major groups, bush beans, and pole beans.

On finding a potent veggie for the prevention of cardiovascular disease, researchers investigated the common bean anti-platelet aggregation activity.

According to the tested analysis, common beans exerted a novel property in the inhibition of thrombotic cardiovascular events.

Furthermore, levels of adenosine 5′-diphosphate and arachidonic acid associated with platelet aggregation were also significantly reduced by the administration of bean extracts. 

Moreover, the surface expression of P-Selectin involved in cell adhesion molecules (CAM) on the surfaces of activated endothelial cells induced platelet aggregation also inhibited the beans extracts.

More precisely, the beans extract the modulates the expression of AKT hypo-phosphorylation decreases in the activation of platelets may be the mechanism underlying such effect.

Based on the findings, researchers said, " common beans are nutritional ingredients that help reduce the risk of cardiovascular diseases associated with platelet hyper-reactivity".

Taken altogether, green beans may process anti platelet aggression against the cardiovascular risk, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phaseolus vulgaris Exerts an Inhibitory Effect on Platelet Aggregation through AKT Dependent Way by Rosio Rodríguez-Azúa,1 Eduardo Fuentes Quinteros,2 Alexandra Olate-Briones,2,3 andRodrigo Moore-Carrasco. (PMC)

Omega -3 Fatty Acids Inhibits the Risk of Cardiovascular Diseases (CVD)

By Kyle J. Norton


Cardiovascular disease (CVD) is a group of conditions associated with the heart and blood vessels.

Heart disease is a class of diseases associated with interruption of blood flow in the blood vessel or damage of the heart tissue, including coronary artery diseases (CAD) such as angina and myocardial infarction.

According to the statistics, heart disease is a leading cause of death in the US. Approximately 2000 people in the general population die of heart disease every day.

Coronary heart disease (CHD) is the most common type of heart disease, that kills over 370,000 people annually.

There are many causes of heart disease. Anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease.

According to the statistic cardiovascular disease is the leading cause of death in women in the US with 90% of women having one risk factor.

Believe it or not, women are 4 times more likely to die from heart disease than breast cancer and 2/3 of women are not aware of heart disease is such a risk for them, according to the Jean Hailes for Women Health in the article cardiovascular health.

Ischemic stroke is an emerging condition associated with plaques building up in the arteries that block the circulation of blood in any part of the body, causing oxygen not to be delivered to the brain, leading to some cells in the brain to die off and are unable to reproduce.

An ischemic stroke happens when a blood vessel in the brain ruptures causing the cells in your brain to be deprived of oxygen in your blood, they die and never come back.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of cardiovascular diseases, researchers examined the polyunsaturated fatty acids (PUFAs) in fish and vegetable oils on CVD.

According to the results of a multiethnic cohort of 2837 US adults (whites, Hispanics, African Americans, Chinese Americans), plasma phospholipid PUFAs that were measured at baseline (2000-2002) using gas chromatography and dietary PUFAs estimated using a food frequency questionnaire, the incident cardiovascular disease (CVD) events (including coronary heart disease and stroke; n=189) were prospectively identified through 2010 during 19 778 person-years of follow-up.

According to the returned questionnaires, circulating n-3 eicosapentaenoic acid and docosahexaenoic acid were inversely associated with incident CVD, with extreme-quartile hazard ratios (95% CIs) of 0.49 for eicosapentaenoic acid (0.30 to 0.79; Ptrend=0.01) and 0.39 for docosahexaenoic acid (0.22 to 0.67.

Furthermore, there were no significant associations with CVD on the circulating n-3 alpha-linolenic acid or n-6 PUFA (linoleic acid, arachidonic acid).

More importantly, docosapentaenoic acid (DPA) was inversely associated with CVD in whites and Chinese, but not in other races/ethnicities (P-interaction=0.01).

After taking into account other con and cofounders, researchers suggested, "Associations with CVD of self-reported dietary PUFA were consistent with those of the PUFA biomarkers. All associations were similar across racial-ethnic groups, except those of docosapentaenoic acid".

And, "Both dietary and circulating eicosapentaenoic acid and docosahexaenoic acid, but not alpha-linolenic acid or n-6 PUFA, were inversely associated with CVD incidence. These findings suggest that increased consumption of n-3 PUFA from seafood may prevent CVD development in a multiethnic population".

Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention and treatment of CVD, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(2) Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis by de Oliveira Otto MC1, Wu JH, Baylin A, Vaidya D, Rich SS, Tsai MY, Jacobs DR Jr, Mozaffarian D. (PubMed)
(2) Sea Change for Marine Omega-3s: Randomized Trials Show Fish Oil Reduces Cardiovascular Events by O'Keefe EL1, Harris WS2, DiNicolantonio JJ3, Elagizi A4, Milani RV4, Lavie CJ4, O'Keefe JH. (PubMed)

Cabbage inhibits the Risk of Gastric Cancer in Vitro

By Kyle J. Norton

The stomach located between the esophagus and the small intestine is a muscular, hollow and important organ of the digestive tract.

The stomach besides serving the container to holding food and the mixer and grinder of food. also makes acid and powerful enzymes that break the food down and change it to a liquid or paste.

Gastric/Stomach cancer is a chronic condition characterized by irregular cell growth in the tissues of the stomach.

Most cases of gastric cancer start in the cells on the surface of the inner lining of stomach tissue.
Due to the small size at the early stage, gastric cancer is asymptomatic.

However, at the later stage, after penetrating into the deeper layers of the stomach, the cancer cell may travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.

Most people with primary cancer have an increased risk of secondary cancers of the thyroid and small intestine.

Gastric cancer affects 2.1% of male cancer patients and 1.3% of female cancer patients in Canada.

In the later stages, stomach cancer has a 5-year survival rate of only 23%, meaning that 77% of stomach cancer patients die within 5 years of diagnosis.

The most common risk factor of gastric cancer is infection with a common bacteria, H. pylori, which were found to cause ulcers and Inflammatory gastritis.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem of which is crowded a mass of leaves, usually green but in some varieties, it may be red or purplish.

With an aim to find natural food that treats chronic diseases, researchers examined the effects of white cabbage on gastric cancer.

According to the selected studies, organic fresh cabbage, compared to the conventional one, contained significantly less total flavonoids in both years of experiments (3.95 ± 0.21 mg/100 g FW and 3.71 ± 0.33 mg/100 g FW), several flavonoid compounds, total chlorophylls (1.51 ± 0.17 mg/100 g FW and 1.30 ± 0.22 mg/100 g FW) carotenoids, nitrites (0.55 ± 0.04 mg/kg FW and 0.45 ± 0.02 mg/kg FW), and nitrates (0.50 ± 0.13 g/kg FW and 0.47 ± 0.11 g/kg FW).

The organic sauerkraut juice, compared to the conventional one, contained significantly more total polyphenols (5.39 ± 0.22 mg/100 g FW and 9.05 ± 1.10 mg/100 g FW) as well as several flavonoids.

Only CONV sauerkraut juice produced with the highest N level of fertilization induced a statistically significant increase in the level of necrosis of human stomach gastric adenocarcinoma cell line AGS.

In other words, organic processes anti colon cancer through its antioxidant compounds compared to CONV sauerkraut juice processed the highest production of N level of fertilization involved in the increase of the level of necrosis of the human stomach gastric adenocarcinoma cell line AGS.

Taken altogether, organic cabbage and kimchi may be considered an anti-gastric cancer functional food, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Nutritive Value of Organic and Conventional White Cabbage (Brassica Oleracea L. Var. Capitata) and Anti-Apoptotic Activity in Gastric Adenocarcinoma Cells of Sauerkraut Juice Produced Therof by Hallmann E1, Kazimierczak R1, Marszałek K2, Drela N3, Kiernozek E3, Toomik P4, Matt D5, Luik A5, Rembiałkowska E. (PubMed)

Omega 3 Fatty Acids, the Promising Adjunct Therapy for Heart Failure Patients

By Kyle J. Norton

The heart is a four-chambered, hollow muscle and a double-acting pump located in the chest between the lungs is a muscular organ in the human body.

The heart formed an important part of the circulatory system that pumps blood through the blood vessels to nourish the body and assist in the removal of metabolic wastes.

According to the statistic provided by the American Heart Foundation, on average, an American dies of CVD every 38 seconds. Cardiovascular disease (CVD) accounted for 840,678 deaths in the US in 2016 and the condition also claims more lives each year than all forms of cancer and chronic lower respiratory disease combined

In 2016, cardiovascular diseases cause the death of 2,303 deaths each day, in the US.
Heart failure is a medical condition characterized by insufficiently maintaining blood flow to meet the body's needs.

Most common symptoms of heart failure are

* Shortness of breath and excessive tiredness are caused by the congestion in your lungs in the process of inhaling oxygen and exhaling carbon dioxide.

And

* Leg swelling is a condition caused by fluid to back up in your lungs and in other parts of your body such as your ankles.

Believe it or not, approximately 600, 000 Canadian are living with heart failure or 16% of the entire population.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of heart diseases, researchers examined the effects of long-chain omega-3 fatty acid supplementation on omega-3 levels on chronic heart failure (CHF).

According to the results of the analysis of a recent clinical trial that was used to develop a Markov model to project clinical outcomes while capturing relevant costs and patient quality of life,

* In addition to standard therapy, n-3 PUFA vs. placebo increased lifetime direct costs by £993 (≈€1150), with an additional quality-adjusted life expectancy of 0.079 quality-adjusted life years (QALYs), and mean lifetime costs of £12,636 (≈€14,600) per QALY gained.

* Probabilistic sensitivity analyses suggested a 60% likelihood of n-3 PUFA being regarded as cost-effective versus placebo at a willingness-to-pay threshold of £30,000 (≈€34,600) per QALY gained.

In other words, the cotreatment of Omega 3 fatty acids with standard therapy improves the quality of life, life expectancy and induced cost-effective in the treatment of heart failure patients.

Moreover, researchers said, "By currently accepted standards of value for money in the UK; the addition of n-3 PUFA to optimal medical therapy for patients with heart failure is likely to be cost-effective".

Taken altogether, Omega-3 fatty acids may be considered an adjunct therapy for the treatment of heart failure, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Long-Chain Omega-3 Fatty Acid Supplements in Depressed Heart Failure Patients: Results of the OCEAN Trial by Jiang W1, Whellan DJ2, Adams KF3, Babyak MA4, Boyle SH4, Wilson JL4, Patel CB5, Rogers JG5, Harris WS6, O'Connor CM. (PubMed)
(2) Cost-effectiveness of highly purified omega-3 polyunsaturated fatty acid ethyl esters in the treatment of chronic heart failure: results of Markov modelling in a UK setting by Cowie MR1, Cure S, Bianic F, McGuire A, Goodall G, Tavazzi L. (PubMed)

Ashwagandha Inhibits Colorectal Cancer by Inducing Mitochondrial Dysfunction

By Kyle J. Norton

Cancer is the class of diseases associated with cell growth disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

Cancer cells at the advanced stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018, 1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Compared to other types of cancer, colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells DNA.

According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.

The lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

Approximately, 140,000 cases of colorectal cancer were diagnosed in the US in 2018. Cancer also causes the death of over 50, 000 people, representing 8.3% of total cancer death.

Being overweight or obese. smoking, physical inactivity, excessive alcohol drinking, the increased in age, family and personal history, genetic preposition are some of the prevalent risks of the disease.

Mitochondrial dysfunction is a condition affecting the organelles that generate energy for the cell.

Mitochondria are the cell that converts the food molecules into the energy for the body tissues' needs. Mitochondria produces 90 percent of the energy for body functioning.

On finding a potent compound that processes the anti-cancer activity, researchers examined the effects of Withaferin A (WA), an active steroidal lactone derived from the herbal plant Withania somnifera cytotoxic induced mitochondrial dysfunction on colorectal cancer (CRC).

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

In vitro, according to the flow cytometry, withaferin A, induced accumulation of ROS in human colon cancer cells to cause apoptosis and cell cycle arrest by inducing the mitochondrial dysfunction that affects the production of energy for the cancer cells' needs.

Furthermore, on HCT-116 and RKO cells, WA exerted a cytotoxic effect on a dose-dependent manner.

Moreover, the anti colorectal cancer cells property of WA was attributed to the ROS production and decreased mitochondrial membrane potential, accompanying with mitochondrial dysfunction. 

Based on the finding, researchers said, " These results strongly indicated that WA directly inhibits cell growth and induces apoptosis in CRC cells through ROS-mediated mitochondrial dysfunction and JNKs pathway, and WA may be a promising potential candidate for therapeutic application of CRC".

Taken altogether, Ashwagandha processed abundantly withaferin A may be considered a functional herb for the treatment of CRC by inducing mitochondrial dysfunction of the cancer cells, pending to the result of larger sample size and multicenter study

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Withaferin A induces apoptosis by ROS-dependent mitochondrial dysfunction in human colorectal cancer cells by Xia S1, Miao Y2, Liu S. (PubMed)